Aminoglycosides
Gentamicins
Framycetin
Tobramycin
Amikacin
Kanamycin
Netilmicin
Microbial Sensitivity Tests
Neomycin
Dibekacin
Drug Resistance, Microbial
Sisomicin
Streptomycin
Pseudomonas aeruginosa
Kanamycin Kinase
Drug Resistance, Bacterial
Drug Resistance, Multiple, Bacterial
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Acetyltransferases
Hygromycin B
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Dihydrostreptomycin Sulfate
Mezlocillin
Butirosin Sulfate
Carbenicillin
beta-Lactamases
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Gram-Negative Bacterial Infections
Hearing Disorders
Cephalosporins
Enterococcus faecalis
Klebsiella pneumoniae
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Codon, Nonsense
An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
Viomycin
Enterococcus
Conjugation, Genetic
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
Piperacillin
Serratia marcescens
Tetracyclines
Polymyxin B
Stria Vascularis
A layer of stratified EPITHELIUM forming the endolymphatic border of the cochlear duct at the lateral wall of the cochlea. Stria vascularis contains primarily three cell types (marginal, intermediate, and basal), and capillaries. The marginal cells directly facing the ENDOLYMPH are important in producing ion gradients and endochoclear potential.
Ampicillin
Ribosome Subunits, Small, Bacterial
Endocarditis, Bacterial
Methyltransferases
R Factors
Vancomycin
Integrons
Lactams
Staphylococcus aureus
Plasmids
Mentha
Ceftazidime
Anti-Infective Agents
Carbapenems
Acinetobacter baumannii
RNA, Ribosomal, 16S
Staphylococcus
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Gram-Positive Bacterial Infections
tRNA Methyltransferases
Gram-Negative Bacteria
Acinetobacter
Codon, Terminator
Lateral Line System
Streptococcus
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Norfloxacin
beta-Lactam Resistance
Drug Therapy, Combination
Cefoperazone
Drug Resistance, Multiple
Proteus mirabilis
Enterobacter
Hearing Loss
Micromonospora
Fatty Alcohols
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Polymyxins
Amebicides
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Hair Cells, Auditory
Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound.
Stenotrophomonas maltophilia
Klebsiella
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.
4-Quinolones
Enoxacin
Xanthenes
Serratia
RNA, Bacterial
Disk Diffusion Antimicrobial Tests
Mutation
Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins. (1/2111)
We examined the inhibitory activity against bacterial peptidoglycan biosynthesis, mammalian glycoprotein biosynthesis and growth of BALB/3T3 cells of four different types of liposidomycins which have the structure with or without sulfate and/or 3-methylglutaric acid moieties. Liposidomycins inhibited peptidoglycan biosynthesis about 30 to 500 times more effectively than tunicamycin, whereas liposidomycins inhibited mammalian glycoprotein biosynthesis about 30 to 300 times less effectively than tunicamycin. When the cytotoxic effect of liposidomycins and tunicamycin on the growth of mammalian cells were compared, liposidomycins did not show toxicity against BALB/3T3 cell at 25 microg/ml, though tunicamycin inhibited cell growth by 50% at 0.05 microg/ml. On the basis of these results, it is concluded that liposidomycins are selective antibiotics showing highly specific inhibition toward bacterial peptidoglycan biosynthesis. (+info)RecA-Mediated gene conversion and aminoglycoside resistance in strains heterozygous for rRNA. (2/2111)
Clinical resistance to aminoglycosides in general is due to enzymatic drug modification. Mutational alterations of the small ribosomal subunit rRNA have recently been found to mediate acquired resistance in bacterial pathogens in vivo. In this study we investigated the effect of 16S rRNA heterozygosity (wild-type [wt] and mutant [mut] operons at position 1408 [1408wt/1408mut]) on aminoglycoside resistance. Using an integrative vector, we introduced a single copy of a mutated rRNA operon (1408 A-->G) into Mycobacterium smegmatis, which carries two chromosomal wild-type rRNA operons; the resultant transformants exhibited an aminoglycoside-sensitive phenotype. In contrast, introduction of the mutated rRNA operon into an M. smegmatis rrnB knockout strain carrying a single functional chromosomal wild-type rRNA operon resulted in aminoglycoside-resistant transformants. Subsequent analysis by DNA sequencing and RNase protection assays unexpectedly demonstrated a homozygous mutant genotype, rRNAmut/rRNAmut, in the resistant transformants. To investigate whether RecA-mediated gene conversion was responsible for the aminoglycoside-resistant phenotype in the rRNAwt/rRNAmut strains, recA mutant strains were generated by allelic exchange techniques. Transformation of the recA rrnB M. smegmatis mutant strains with an integrative vector expressing a mutated rRNA operon (Escherichia coli position 1408 A-->G) resulted in transformants with an aminoglycoside-sensitive phenotype. Subsequent analysis showed stable heterozygosity at 16S rRNA position 1408 with a single wild-type allele and a single resistant allele. These results demonstrate that rRNA-mediated mutational resistance to aminoglycosides is recessive. (+info)Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria. (3/2111)
Nosocomial pneumonia is a notable cause of morbidity and mortality and leads to increases in lengths of hospital stays and institutional expenditures. Aminoglycosides are used to treat patients with these infections, but few data on the doses and schedules required to achieve optimal therapeutic outcomes exist. We analyzed aminoglycoside treatment data for 78 patients with nosocomial pneumonia to determine if optimization of aminoglycoside pharmacodynamic parameters results in a more rapid therapeutic response (defined by outcome and days to leukocyte count resolution and temperature resolution). Cox proportional hazards, Classification and Regression Tree (CART), and logistic regression analyses were applied to the data. By all analyses, the first measured maximum concentration of drug in serum (Cmax)/MIC predicted days to temperature resolution and the second measured Cmax/MIC predicted days to leukocyte count resolution. For days to temperature resolution and leukocyte count resolution, CART analyses produced breakpoints, with an 89% success rate at 7 days of therapy for a Cmax/MIC of > 4.7 and an 86% success rate at 7 days of therapy for a Cmax/MIC of > 4.5, respectively. Logistic regression analyses predicted a 90% probability of temperature resolution and leukocyte count resolution by day 7 if a Cmax/MIC of > or = 10 is achieved within the first 48 h of aminoglycoside therapy. Aggressive aminoglycoside dosing immediately followed by individualized pharmacokinetic monitoring would ensure that Cmax/MIC targets are achieved early in therapy. This would increase the probability of a rapid therapeutic response for pneumonia caused by gram-negative bacteria and potentially decreasing durations of parenteral antibiotic therapy, lengths of hospitalization, and institutional expenditures, a situation in which both the patient and the institution benefit. (+info)Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides. (4/2111)
The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the treatment of experimental endocarditis due to HLRAg E. faecalis. A reduction of 1 to 4 dilutions in MICs of ampicillin was obtained when ampicillin was combined with a fixed subinhibitory ceftriaxone concentration of 4 micrograms/ml. This potentiating effect was also observed by the double disk method with all 10 strains. Time-kill studies performed with 1 and 2 micrograms of ampicillin alone per ml or in combination with 5, 10, 20, 40, and 60 micrograms of ceftriaxone per ml showed a > or = 2 log10 reduction in CFU per milliliter with respect to ampicillin alone and to the initial inoculum for all 10 E. faecalis strains studied. This effect was obtained for seven strains with the combination of 2 micrograms of ampicillin per ml plus 10 micrograms of ceftriaxone per ml and for six strains with 5 micrograms of ceftriaxone per ml. Animals with catheter-induced endocarditis were infected intravenously with 10(8) CFU of E. faecalis V48 or 10(5) CFU of E. faecalis V45 and were treated for 3 days with humanlike pharmacokinetics of 2 g of ampicillin every 4 h, alone or combined with 2 g of ceftriaxone every 12 h. The levels in serum and the pharmacokinetic parameters of the humanlike pharmacokinetics of ampicillin or ceftriaxone in rabbits were similar to those found in humans treated with 2 g of ampicillin or ceftriaxone intravenously. Results of the therapy for experimental endocarditis caused by E. faecalis V48 or V45 showed that the residual bacterial titers in aortic valve vegetations were significantly lower in the animals treated with the combinations of ampicillin plus ceftriaxone than in those treated with ampicillin alone (P < 0.001). The combination of ampicillin and ceftriaxone showed in vitro and in vivo synergism against HLRAg E. faecalis. (+info)Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro. (5/2111)
HIV gene expression is crucially dependent on binding of the viral Tat protein to the transactivation RNA response element. A number of synthetic Tat-transactivation responsive element interaction inhibitors of peptide/peptoid nature were described as potential antiviral drug prototypes. We present a new class of peptidomimetic inhibitors, conjugates of L-arginine with aminoglycosides. Using a gel-shift assay and affinity chromatography on an L-arginine column we found that these compounds bind specifically to the transactivation responsive element RNA in vitro with Kd values in the range of 20-400 nM, which is comparable to the Kd of native Tat bound to the transactivation responsive element (10-12 nM). Confocal microscopy studies demonstrated that fluorescein-labelled conjugate penetrates into live cells. High affinity to the transactivation responsive element, low toxicity, and relative simplicity of synthesis make these compounds attractive candidates for antiviral drug design. (+info)The therapeutic monitoring of antimicrobial agents. (6/2111)
AIMS: To review the basis and optimal use of therapeutic drug monitoring of antimicrobial agents. METHODS: Antimicrobial agents for which a reasonable case exists for therapeutic drug monitoring were reviewed under the following headings: pharmacokinetics, why monitor, therapeutic range, individualisation of therapy, sampling times, methods of analysis, interpretative problems and cost-effectiveness of monitoring. RESULTS: There is a strong historical case for monitoring aminoglycosides. The recent move to once-daily dosing means that criteria for therapeutic drug monitoring need to be redefined. Vancomycin has been monitored routinely but many questions remain about the most appropriate approach to this. A case can be made for monitoring teicoplanin, flucytosine and itraconazole in certain circumstances. CONCLUSIONS: The approach to monitoring aminoglycosides needs to be redefined in the light of once-daily dosing. It is premature to suggest that less stringent monitoring is necessary as toxicity remains a problem with these drugs. The ideal method of monitoring vancomycin remains to be defined although a reasonable case exists for measuring trough concentrations, mainly to ensure efficacy. Teicoplanin is monitored occasionally to ensure efficacy while flucytosine is monitored occasionally to avoid high concentrations associated with toxicity. Itraconazole has various pharmacokinetic problems and monitoring has been suggested to ensure that adequate concentrations are achieved. (+info)Recovery of the vestibulocolic reflex after aminoglycoside ototoxicity in domestic chickens. (7/2111)
Avian auditory and vestibular hair cells regenerate after damage by ototoxic drugs, but until recently there was little evidence that regenerated vestibular hair cells function normally. In an earlier study we showed that the vestibuloocular reflex (VOR) is eliminated with aminoglycoside antibiotic treatment and recovers as hair cells regenerate. The VOR, which stabilizes the eye in the head, is an open-loop system that is thought to depend largely on regularly firing afferents. Recovery of the VOR is highly correlated with the regeneration of type I hair cells. In contrast, the vestibulocolic reflex (VCR), which stabilizes the head in space, is a closed-loop, negative-feedback system that seems to depend more on irregularly firing afferent input and is thought to be subserved by different circuitry than the VOR. We examined whether this different reflex also of vestibular origin would show similar recovery after hair cell regeneration. Lesions of the vestibular hair cells of 10-day-old chicks were created by a 5-day course of streptomycin sulfate. One day after completion of streptomycin treatment there was no measurable VCR gain, and total hair cell density was approximately 35% of that in untreated, age-matched controls. At 2 wk postlesion there was significant recovery of the VCR; at this time two subjects showed VCR gains within the range of control chicks. At 3 wk postlesion all subjects showed VCR gains and phase shifts within the normal range. These data show that the VCR recovers before the VOR. Unlike VOR gain, recovering VCR gain correlates equally well with the density of regenerating type I and type II vestibular hair cells, except at high frequencies. Several factors other than hair cell regeneration, such as length of stereocilia, reafferentation of hair cells, and compensation involving central neural pathways, may be involved in behavioral recovery. Our data suggest that one or more of these factors differentially affect the recovery of these two vestibular reflexes. (+info)Antibiotic penetrance of ascitic fluid in dogs. (8/2111)
Antibiotic concentrations in ascitic fluid after parenteral therapy may be important in the treatment of peritonitis. We have created ascites in dogs by partial ligation of the inferior vena cava. Ascitic fluid volume was measured at the time each antibiotic was administered. Nine antibiotics were studied in the same three dogs. Antibiotic concentration in ascitic fluid was found to vary inversely with ascites volume. Percentage of penetration (ratio of ascites peak to serum peak x100) ranged from 5.8 to 65% among the drugs studied. Only metronidazole showed a statistically significant higher percentage of penetration than other antimicrobials. Concentrations in ascitic fluid after single doses of cephalothin (15 mg/kg) and the aminoglycosides (2 mg/kg, gentamicin and tobramycin; 7.5 mg/kg, amikacin and kanamycin) did not exceed the minimum inhibitory concentration of many gram-negative rods and may justify the use of higher than usual initial parenteral doses, or possibly initial intraperitoneal administration in seriously ill patients. (+info)
Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)<...
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Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia - Full Text...
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Enzyme-mediated resistance to antibiotics : mechanisms, by Robert A. Bonomo, Marcelo E. Tolmasky - Stowarzyszenie Books
Caution on aminoglycoside use after study shows increase risk in kids with febrile neutropenia
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Neosulf
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Anti-bacterial Agents, Antibiotics, ATC:A01AB08, ATC:A07AA01, ATC:B05CA09, ATC:D06AX04, ATC...
Neofracin
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Correlation of pharmacokinetic indices with therapeutic outcome in patients receiving aminoglycosides<...
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Plus it
Aminoglycosides Market to Witness an Outstanding Growth by 2017 - 2025 : Persistence Market Research | Medgadget
Tirandamycin - Wikipedia
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UPLC/MS/MS Determination of Aminoglycoside Antibiotics in Meat and Milk : Waters
The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis
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NLP SNP
Effect and safety of gemtuzumab ozogamicin for the treatment of patients with acute myeloid leukaemia: a systematic review...
Aminoglycosides Residue Testing Service - Creative Proteomics
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ARDB-Antibiotic Resistance Genes Database
ARDB-Antibiotic Resistance Genes Database
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Antibiotics - The Perfect Storm: Telavancin, Astellas and Theravance - Implications?
Methods for determining proteins and protein-bound compounds comprising enzymatic modification - diagram, schematic, and image...
Structure Cluster
- 4AQY: Structure of ribosome-apramycin complexes 3D Similarity Report Page
Patent US4078138 - 3-Epi-4deoxykanamycin B - Google Patents
RCSB PDB - Protein Feature View
- Aminoglycoside-(3)-N-acetyltransferase - Q53396 (Q53396 SERMA)
Market Analysis and Business Oppurtunities of Antibiotics
Biochemicals
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Pfizer to Withdraw Cancer Drug Mylotarg | Robert Kraft - JDSupra
JCI -
Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death
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Selective inactivation of aminoglycosides by newer beta-lactam antibiotics<...
Aminoglycoside-induced hearing loss
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SAMU MEDIAN CO.,LTD.
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Aminoglycoside antibiotics
Rebeccamycin
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Gentamicin Sulfate Solution
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Amikacin
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Aminoglycoside
Frequent use of aminoglycosides could result in kidney damage, that could lead to chronic kidney disease. Aminoglycosides can ... DVM Boothe, DVM, PhD, 2012, Aminoglycosides (Aminocyclitols), The Merck Veterinary Manual "Aminoglycosides: Antibacterial ... Aminoglycosides (Aminocyclitols), The Merck Veterinary Manual "Aminoglycosides: Antibacterial Agents: Merck Veterinary Manual ... The aminoglycoside gentamicin has been used to treat cystic fibrosis (CF) cells in the laboratory to induce them to grow full- ...
Aminoglycoside N6'-acetyltransferase
Other names in common use include aminoglycoside 6'-N-acetyltransferase, aminoglycoside-6'-acetyltransferase, aminoglycoside-6- ... In enzymology, an aminoglycoside N6'-acetyltransferase (EC 2.3.1.82) is an enzyme that catalyzes the chemical reaction acetyl- ... Benveniste R, Davies J (1971). "Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor". ...
Aminoglycoside N3'-acetyltransferase
Other names in common use include 3'-aminoglycoside acetyltransferase, and 3-N-aminoglycoside acetyltransferase. Davies J, ... In enzymology, an aminoglycoside N3'-acetyltransferase (EC 2.3.1.81) is an enzyme that catalyzes the chemical reaction acetyl- ... 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin". Antimicrob. ... O'Connor S (1978). "Enzymatic modification of aminoglycoside antibiotics: ...
Amikacin
Variations of aminoglycoside acetyltransferase (AAC) and aminoglycoside adenylyltransferase (AAD) also confer resistance: ... an allergy to one aminoglycoside also confers hypersensitivity to other aminoglycosides). It should also be avoided in those ... Amikacin, like other aminoglycoside antibiotics, can cause hearing loss, balance problems, and kidney problems. Other side ... Amikacin can be inactivated by other beta-lactams, though not to the extent as other aminoglycosides, and is still often used ...
Streptomyces mashuensis
Aminoglycoside Antibiotics. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 3-642-68579-X. {{cite book}}: ,first1= has ...
Streptomyces kasugaensis
Aminoglycoside Antibiotics. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 3-642-68579-X. {{cite book}}: ,first1= has ... "Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two ...
Kanamycin kinase
Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the ... Aminoglycoside resistance genes are commonly used in the realm of genetic engineering in order to select for correctly ... Antibiotics, such as the aminoglycosides kanamycin or neomycin, are added to the cultures during growth phases in order to ... However, APH(3') has also been found to phosphorylate at the 5'-hydroxyl group in 4,5-disubstituted aminoglycosides, which lack ...
Kingella kingae
Options include aminoglycosides, macrolides and fluoroquinolones. K. kingae can also cause infectious endocarditis, in children ...
Delftia acidovorans
Antibiotic resistance to aminoglycosides is common. Wen, Aimin; Fegan, Mark; Hayward, Chris; Chakraborty, Sukumar; Sly, Lindsay ...
Ototoxic medication
Aminoglycosides are a class of antibiotics. The most frequently used aminoglycosides include gentamicin, amikacin and ... The mechanism of aminoglycosides-induced ototoxicity is not well understood. It is thought that because cochlear cells are rich ... Aminoglycosides irreversibly inhibit protein synthesis of bacteria, which specifically helps kill the gram-negative bacteria. ... All aminoglycosides can cause either reversible or irreversible ototoxicity. Ototoxicity is more frequently observed in ...
Tobramycin
Like all aminoglycosides, tobramycin does not pass the gastro-intestinal tract, so for systemic use it can only be given ... Like other aminoglycosides, a major side effect for tobramycin is ototoxicity or a loss of equilibrioception, or both in ... Tobramycin is an aminoglycoside antibiotic derived from Streptomyces tenebrarius that is used to treat various types of ... Kotra LP, Haddad J, Mobashery S (December 2000). "Aminoglycosides: perspectives on mechanisms of action and resistance and ...
Gentamicin
Kidney damage is a problem in 10-25% of people who receive aminoglycosides, and gentamicin is one of the most nephrotoxic drugs ... Gentamicin C2b, an aminoglycoside antibiotic produced by Micromonospora purpurea mutant JI-33". The Journal of Antibiotics. 28 ... Gentamicin is a type of aminoglycoside. It works by disrupting the ability of the bacteria to make proteins, which typically ... About 11% of the population who receives aminoglycosides experience damage to their inner ear. The common symptoms of inner ear ...
Karen Joy Shaw
Aminoglycoside resistance/diagnostics. As a leader in the field of aminoglycoside resistance Shaw was involved in the cloning ... "The Most Frequent Aminoglycoside Resistance Mechanisms--Changes with Time and Geographic Area: A Reflection of Aminoglycoside ... "Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes". ... She is best known for her work on aminoglycoside resistance in bacteria as well as leading drug discovery research teams. As ...
Acute tubular necrosis
Tulkens, P.M. (March 1989). "Nephrotoxicity of aminoglycoside antibiotics". Toxicology Letters. 46 (1-3): 107-123. doi:10.1016/ ... by medication including antibiotics such as aminoglycoside, statins such as atorvastatin, bisphosphonates like pamidronate and ...
Dizocilpine
NMDA antagonists like dizocilpine have been shown in animal models to attenuate the hearing loss caused by aminoglycosides It ... Ernfors P, Canlon B (December 1996). "Aminoglycoside excitement silences hearing". Nat. Med. 2 (12): 1313-4. doi:10.1038/nm1296 ... "N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss". Nat. Med. 2 (12): 1338-43. doi:10.1038/ ... is thought that aminoglycosides mimic endogenous polyamines at NMDA receptors and produce excitotoxic damage, leading to hair ...
Streptomycin
... is an aminoglycoside. It works by blocking the ability of 30S ribosomal subunits to make proteins, which results ... Prayle A, Watson A, Fortnum H, Smyth A (July 2010). "Side effects of aminoglycosides on the kidney, ear and balance in cystic ... as with other aminoglycosides, are kidney toxicity and ear toxicity. Transient or permanent deafness may result. The vestibular ... Aminoglycoside antibiotics, Anti-tuberculosis drugs, Guanidines, Secondary amines, World Health Organization essential ...
Bartonella henselae
Aminoglycosides in laboratory tests showed some bactericidal activity. Bacteriostatic antibiotics are not able to easily get ...
Antibiotic
Compounds that are still isolated from living organisms are the aminoglycosides, whereas other antibacterials-for example, the ... Allison KR, Brynildsen MP, Collins JJ (May 2011). "Metabolite-enabled eradication of bacterial persisters by aminoglycosides". ... Plazomicin (ACHN-490): semi-synthetic aminoglycoside derivative (protein synthesis inhibitor). FDA approved 25 June 2018. ... rendering them more susceptible to killing by aminoglycoside antibiotics. Natural products may be screened for the ability to ...
Micromonospora sagamiensis
It produces sagamicin, an aminoglycoside antibiotic, as well as several mutational variants. Its cell wall contains only D- ... Kase, Hiroshi; Odakura, Yoshihiro; Nakayama, Kiyoshi (1982). "Sagamicin and the related aminoglycosides: Fermentation and ...
Burkholderia vietnamiensis
It differs from most Burkholderia species in that it is often susceptible to aminoglycosides, but not polymyxin B. Many ... "In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides". Antimicrob. Agents Chemother. 55 (5): 2256-64. doi: ...
Beta-lactamase
Some patients have responded to aminoglycoside or quinolone therapy, but, in a recent comparison of ciprofloxacin and imipenem ... Resistance to fluoroquinolones and aminoglycosides is especially high. For infections caused by ESBL-producing Escherichia coli ... Associated resistance to aminoglycosides and trimethoprim-sulfamethoxazole, as well as high frequency of co-existence of ... aminoglycosides). Therefore, antibiotic options in the treatment of ESBL-producing organisms are extremely limited. Carbapenems ...
Protein synthesis inhibitor
Macrolides, clindamycin and aminoglycosides (with all these three having other potential mechanisms of action as well), have ... Aminoglycosides prevent ribosome assembly by binding to the bacterial 30S ribosomal subunit. Tetracyclines and Tigecycline (a ... Aminoglycosides, among other potential mechanisms of action, interfere with the proofreading process, causing increased rate of ... Retapamulin Mupirocin Fusidic acid The following antibiotics bind to the 30S subunit of the ribosome: Aminoglycosides ...
Mequitazine
Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation (which can lead to torsades de pointes arrhythmia) ...
Persister cells
A study has shown that adding certain metabolites to aminoglycosides could enable bacterial persisters to be eliminated. This ... Allison KR, Brynildsen MP, Collins JJ (2011). "Metabolite-enabled eradication of bacterial persisters by aminoglycosides". ...
Proofreading (biology)
Pharmamotion --> Protein synthesis inhibitors: aminoglycosides mechanism of action animation. Classification of agents Archived ...
Medication
Antibacterial: antibiotics, topical antibiotics, sulfa drugs, aminoglycosides, fluoroquinolones. Antiviral drugs. Anti-fungal: ...
Micronomicin
... (INN) is an aminoglycoside antibiotic for use on the eye. Odakura Y, Kase H, Nakayama K (February 1983). " ... "Sagamicin and the related aminoglycosides: fermentation and biosynthesis. III. Isolation and characterization of Micromonospora ... Aminoglycoside antibiotics, All stub articles, Antibiotic stubs). ...
Streptoduocin
... is an aminoglycoside antibiotic. It is a mixture of streptomycin and dihydrostreptomycin. SHUBIN H, HEIKEN CA, ... Aminoglycoside antibiotics, Combination antibiotics, All stub articles, Antibiotic stubs). ...
Netilmicin
Nonparallel nephrotoxicity dose-response curves of aminoglycosides: Nephrotoxicity comparisons of aminoglycosides in rats, ... Aminoglycoside antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is ... Daily single-dose aminoglycoside administration. Therapeutic and economic benefits: Animal studies have shown that dosing ... Relative efficacy and toxicity of netilmicin and tobramycin in oncology patients: We conclude that aminoglycoside-associated ...
Ribostamycin
... is an aminoglycoside-aminocyclitol antibiotic isolated from a streptomycete, Streptomyces ribosidificus, ... Ribostamycin, along with other aminoglycosides with the DOS subunit, is an important broad-spectrum antibiotic with important ... ISBN 978-92-4-150448-5. Kudo F, Eguchi T (September 2009). "Biosynthetic genes for aminoglycoside antibiotics". The Journal of ... Resistance against aminoglycoside antibiotics, such as ribostamycin, is a growing concern. The resistant bacteria contain ...
Reactions Associated With Aminoglycosides, Clindamycin, Linezolid, and Metronidazole
Aminoglycosides consist of two main structural groups: streptidine group (e.g., streptomycin) and the deoxystreptamine group (e ... On the other hand, cross-reactivity between streptomycin and other aminoglycosides is much lower at only 1% to 5% based on ... There are no validated skin tests to assess for immediate hypersensitivity reactions to aminoglycosides. Skin prick tests (SPTs ... A recent review examined immediate- and delayed-hypersensitivity reactions associated with the use of aminoglycosides, ...
Bacterial Pneumonia Medication: Fluoroquinolones, Cephalosporins, Macrolides, Monobactams, Antibiotics, Lincosamide,...
Antipseudomonal beta-lactam plus ciprofloxacin, levofloxacin, or aminoglycoside. Aminoglycoside plus ciprofloxacin or ... Gentamicin is an aminoglycoside antibiotic for gram-negative coverage. This drug is used in combination with both an agent ... Use this agent with caution in patients with renal impairment (coadministration with furosemide and aminoglycosides increases ... An alternative regimen includes a penicillinase-resistant penicillin plus an antipseudomonal aminoglycoside. ...
Aminoglycoside Market Size & Share | Industry Report, 2022
The global aminoglycosides market size to be valued at USD 1.68 billion by 2022 and is expected to grow at a compound annual ... Aminoglycoside Market Size & Share, Industry Report, 2022 GVR Report cover Aminoglycosides Market Size, Share & Trends Analysis ... What is the aminoglycosides market growth? b. The global aminoglycosides market is expected to grow at a compound annual growth ... How big is the aminoglycosides market? b. The global aminoglycosides market size was estimated at USD 1.1 billion in 2019 and ...
armA and Aminoglycoside Resistance in Escherichia coli - Volume 11, Number 6-June 2005 - Emerging Infectious Diseases journal -...
Galimand M, Sabtcheva S, Kantardjiev T, Poirel L, Arlet G, Courvalin P, The armA aminoglycoside resistance methylase is ... which was highly resistant to aminoglycosides and sulfonamides. Resistance to aminoglycosides and the sulfonamides could be ... Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol. 1997;5:234-40. DOIPubMedGoogle Scholar ... Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides. J Mol Biol. 1987;193:661-71. DOI ...
ATC J01G: Aminoglycoside antibacterials and breastfeeding. Which are compatible?
ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity : Sussex Research Online
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Global Aminoglycoside Antibiotics Market Analysis, Size, Share, Growth Trends and Forecast 2023-2033
Global Aminoglycoside Antibiotics Market Analysis:. The Aminoglycoside Antibiotics report overview is a compilation of the ... The difference between your Aminoglycoside Antibiotics spend and the Aminoglycoside Antibiotics selling price is your gross ... The global aminoglycoside antibiotics market is divided into North America; Europe; Asia Pacific; Latin America; The Middle ... Global Aminoglycoside Antibiotics Market Analysis, Size, Share, Growth Trends and Forecast 2023-2033 0 ...
Aminoglycoside Collaborative Practice | Pharmacy
Aminoglycosides Antibiotics
Vestibular Reflex Changes Following Aminoglycoside-lnduced Ototoxicity | JAMA Otolaryngology-Head & Neck Surgery | JAMA Network
The effects of aminoglycoside antibiotic therapy on the horizontal vetibulo-ocular reflex in response to rotatory stimulation ... The effects of aminoglycoside antibiotic therapy on the horizontal vetibulo-ocular reflex in response to rotatory stimulation ... Aminoglycoside therapy resulted in both decreased amplitude and decreased time constant of the vestibulo-ocular reflex. ... Vestibular Reflex Changes Following Aminoglycoside-lnduced Ototoxicity. Arch Otolaryngol Head Neck Surg. 1987;113(4):357. doi: ...
Aminoglycosides - My Blog
Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage | Nature Communications
Analysis of aminoglycosides. The analysis of aminoglycosides in the sewage samples was performed as in Bello53, with ... Study of the aminoglycoside subsistence phenotype of bacteria residing in the gut of humans and zoo animals. Front. Microbiol. ... The aminoglycosides were eluted with 3 mL of acetic acid (10% in MeOH). The eluate was dried at 60 °C, evaporated under N2 and ... To one of these portions, aminoglycosides were added at a level of 50 μg/L. Twenty mL of extraction liquid (10 mM KH2PO4 with ...
Aminoglycoside Antibiotic (Antibiotics Aminoglycoside): Symptoms, Diagnosis and Treatment - Symptoma
Antibiotics Aminoglycoside): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... The significance of the Aminoglycosides Blood Test result is explained: A high Aminoglycosides Blood Test value may indicate ... The aminoglycosides can cause deafness and TINNITUS if taken in excess or if not excreted normally because of kidney disease. [ ... Aminoglycosides are also used in combination therapy with penicillins for the treatment of enterococcal infections. Some ...
Urethritis Medication: Antibiotics, Fluoroquinolones, Cephalosporins, 3rd Generation, Tetracyclines, Macrolides, Aminoglycosides
DEAFNESS, AMINOGLYCOSIDE-INDUCED
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aminoglycoside | Taber's Medical Dictionary
aminoglycoside answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, ... aminoglycoside is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please log in or purchase a ... "Aminoglycoside." Tabers Medical Dictionary, 24th ed., F.A. Davis Company, 2021. Nursing Central Redesign, nursing. ... unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/742172/all/aminoglycoside. Aminoglycoside. In: Venes DD, ed. Tabers ...
Aminoglycoside Calculator - ClinCalc.com
Advanced aminoglycoside pharmacokinetic calculator. Includes a variety of dosing strategies and calulation methods to determine ... Aminoglycoside Calculator Advanced aminoglycoside pharmacokinetics tool. ClinCalc.com » Infectious Disease » Aminoglycoside ... Aminoglycosides are both nephrotoxic and ototoxic (vestibular and auditory). Uptake of aminoglycosides into renal and ... Aminoglycosides weight-based dosing should be based on ideal or adjusted body weight. The following criteria are used by this ...
Neonatal Intensive Care Drug Therapy Update: A Bibliography | Article | NursingCenter
Aminoglycoside resistance mechanisms in clinical isolates of Pseudomonas aeruginosa from the Canary Islands | accedaCRIS
Aminoglycoside resistance mechanisms in clinical isolates of Pseudomonas aeruginosa from the Canary Islands. ... Hybridization was made with 18 DNA probes for the most frequent genes encoding for aminoglycoside-modifying enzymes. All ... Strains of Pseudomonas aeruginosa resistant to aminoglycoside antibiotics were selected from 152 clinical isolates. We ...
Antibiotics Tested by NARMS | NARMS | CDC
Amikacin and other Aminoglycosides - Insights on Health and Wellness
Correlation of aminoglycoside dosages with serum concentrations during therapy of serious gram-negative bacillary disease
Five-year surveillance of aminoglycoside usage in a university hospital<...
Prospective surveillance of aminoglycoside use and of bacterial resistance to aminoglycoside was done before and after the ... Prospective surveillance of aminoglycoside use and of bacterial resistance to aminoglycoside was done before and after the ... Prospective surveillance of aminoglycoside use and of bacterial resistance to aminoglycoside was done before and after the ... Prospective surveillance of aminoglycoside use and of bacterial resistance to aminoglycoside was done before and after the ...
These highlights do not include all the information needed to use ZOLEDRONIC ACID INJECTION safely and effectively. See full...
7.1 Aminoglycosides and Calcitonin. Caution is advised when bisphosphonates are administered with aminoglycosides or calcitonin ... 7.1 Aminoglycosides and Calcitonin 7.2 Loop Diuretics 7.3 Nephrotoxic Drugs 7.4 Thalidomide 8 USE IN SPECIFIC POPULATIONS 8.1 ... Aminoglycosides: May have an additive effect to lower serum calcium for prolonged periods (7.1) (7) ...
Genotypic characterization of aminoglycoside resistance genes from bacteria isolates in selected municipal drinking water...
Genotypic characterization of aminoglycoside resistance genes from bacteria isolates in se Genotypic characterization of ... Index: AIM (Africa) Main subject: Disease Transmission, Infectious / Drug Resistance, Bacterial / Genes / Aminoglycosides / ... Index: AIM (Africa) Main subject: Disease Transmission, Infectious / Drug Resistance, Bacterial / Genes / Aminoglycosides / ... Few studies have investigated occurrence of Antibiotic Resistance Genes (ARGs) among bacteria including Aminoglycoside ...
IMSEAR at SEARO: Antimicrobial resistance among gram-negative bacilli to newer aminoglycosides and beta-lactams.
When tested against newer aminoglycosides, 48.9% were resistant to tobramycin, 4.1% to amikacin and 20.5% to netilmicin. Marked ... Jain S, Sarkar R. Antimicrobial resistance among gram-negative bacilli to newer aminoglycosides and beta-lactams. Indian ... Antimicrobial resistance among gram-negative bacilli to newer aminoglycosides and beta-lactams. ...