Aromatase Inhibitors
18-Hydroxydesoxycorticosterone
Menopause
Androstenedione
Tamoxifen
Hydrocortisone
Sleep Stages
Dehydroepiandrosterone
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.
Adrenergic Agents
Androstenediols
Estrone
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
Adrenal Cortex
The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.
Adrenocorticotropic Hormone
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
Metyrapone
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Danazol
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Cortisone
Neoplasms, Hormone-Dependent
Adrenal Glands
Aromatase
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
A proposed sequence of hormones controlling the induction of luteal 20alpha-hydroxy steroid dehydrogenase and progesterone withdrawal in the late-pregnant rat. (1/183)
1. The previously reported induction of luteal 20alpha-hydroxy steroid dehydrogenase by administration of aminoglutethimide to late-pregnant rats was shown to be unaffected by prior removal of the foetuses. Aminoglutethimide therefore does not act via the foetuses in this context. 2. The ability of injected oestrogen to prevent the above induction was lost by delaying the injection for 12h after aminoglutethimide, although the increase in enzyme activity begins only after 24h. 3. Induction of 20alpha-hydroxy steroid dehydrogenase by foetoplacental removal on day 18 of pregnancy was inhibited by human choriogonadotropin, lutropin (luteinizing hormone) and pregnant-mare serum gonadotropin, but not by somatotropin (growth hormone), thyrotropin or follitropin (follicle-stimulating hormone) 4. Indomethacin blocked the normal induction of 20alpha-hydroxy steroid dehydrogenase in late pregnancy and that caused by aminoglutethimide. It partially blocked that caused by human choriogonadotropin given on days 19-20 and that caused by 2-bromo-alpha-ergocryptine on days 5-6, but failed to block that caused by human choriogonadotropin on days 15-16 or by foetoplacental removal on day 18 of pregnancy. 5. These findings, and the control of progesterone synthesis in late pregnancy, are interpreted in terms of a sequence of hormonal or enzymic syntheses, each of which is inhibited by the product of the preceding synthesis. (+info)Product of side-chain cleavage of cholesterol, isocaproaldehyde, is an endogenous specific substrate of mouse vas deferens protein, an aldose reductase-like protein in adrenocortical cells. (2/183)
Mouse vas deferens protein (MVDP) is an aldose reductase-like protein that is highly expressed in the vas deferens and adrenal glands and whose physiological functions were unknown. We hereby describe the enzymatic characteristics of MVDP and its role in murine adrenocortical Y1 cells. The murine aldose reductase (AR) and MVDP cDNAs were expressed in bacteria to obtain recombinant proteins and to compare their enzymatic activities. Recombinant MVDP was functional and displayed kinetic properties distinct from those of murine AR toward various substrates, a preference for NADH, and insensitivity to AR inhibitors. For MVDP, isocaproaldehyde, a product of side-chain cleavage of cholesterol generated during steroidogenesis, is the best natural substrate identified so far. In Y1 cells, we found that NADH-linked isocaproaldehyde reductase (ICR) activity was much higher than NADPH-linked ICR activity and was not abolished by AR inhibitors. We demonstrate that in Y1 cells, forskolin-induced MVDP expression enhanced NADH-linked ICR activity by 5-6-fold, whereas no variation in ICR-linked NADPH activity was observed in the same experiment. In cells stably transfected with MVDP antisense cDNA, NADH-linked ICR activity was abolished even in the presence of forskolin, and the isocaproaldehyde toxicity was increased compared with that of intact Y1 cells, as measured by isocaproaldehyde LD(50). In Y1 cells transfected with MVDP antisense cDNA, forskolin-induced toxicity was abolished by aminoglutethimide. These results indicate that in adrenocortical cells, MVDP is responsible for detoxifying isocaproaldehyde generated by steroidogenesis. (+info)Decreased progesterone levels and progesterone receptor antagonists promote apoptotic cell death in bovine luteal cells. (3/183)
We tested the hypothesis that progesterone (P(4)) acts at a local level to inhibit luteal apoptosis. Initial experiments employed aminoglutethimide, a P450 cholesterol side-chain cleavage inhibitor, to inhibit steroid synthesis. Cultured bovine luteal cells were treated with aminoglutethimide (0.15 mM) +/- P(4) (500 ng/ml) for 48 h. Luteal cells were recovered and snap frozen for isolation and analysis of oligonucleosomal DNA fragmentation or fixed for morphological analysis. Medium was collected for analysis of P(4) levels by RIA. Aminoglutethimide inhibited P(4) synthesis by > 95% and increased the level of apoptosis as evidenced by (32)P-labeled oligonucleosomal DNA fragmentation (> 40%). P(4) supplementation inhibited the onset of apoptosis that was induced by aminoglutethimide. These data were further supported by morphological assessment of apoptotic cells utilizing a Hoechst staining technique and together strongly suggest that P(4) has anti-apoptotic capacity. Using reverse transcription-polymerase chain reaction, we were able to isolate a 380-base pair cDNA from the bovine corpus luteum (CL) that was 100% homologous to the progesterone receptor (PR) previously found in bovine oviductal tissue. Furthermore, PR transcripts were present in large and small luteal cells. Immunohistochemistry also revealed that PR protein was present in both large and small luteal cells. To determine whether the anti-apoptotic effect of P(4) was regulated at the receptor level, luteal cells were cultured in the presence of PR antagonists, RU-486 and onapristone, for 48 h. Both antagonists caused approximately a 40% increase in (32)P-labeled oligonucleosomal DNA fragmentation. Interestingly, there was no difference (P >/= 0.05) in P(4) levels after treatment with PR antagonists. These observations support the concept that P(4) represses the onset of apoptosis in the CL by a PR-dependent mechanism. (+info)Status of aromatase inhibitors in relation to other breast cancer treatment modalities. (4/183)
Aromatase is one of the key enzymes possibly linked with the perpetuation or even initiation of breast cancer. Modulation of its activity by the new generation inhibitors has resulted in increased responses and improved therapeutic ratio compared with those of parent aromatase inhibitors. More recent trials have shown promising results with regard to improved therapeutic ratio compared with what is seen with presently accepted second-line hormonal approaches. Present data and laboratory research indicate that new aromatase inhibitors have the potential to play an important role as adjuvants, and possibly in the prevention of human breast cancer. It is probable that it may be as adjuvants that their real therapeutic strength in terms of a beneficial impact on survival may be realized. The absence of estrogen agonist activity of new aromatase inhibitors on lipid and bone metabolism calls for more clinical studies having late mortality in breast cancer survivors as the ultimate outcome objective; in this regard, interaction of new aromatase inhibitors with new selective estrogen receptor modulators looks promising. Achievement of these outcomes, and understanding of interactions with other therapies, await the termination of present trials and the start of new initiatives. (+info)Use of aromatase inhibitors in breast carcinoma. (5/183)
Aromatase, a cytochrome P-450 enzyme that catalyzes the conversion of androgens to estrogens, is the major mechanism of estrogen synthesis in the post-menopausal woman. We review some of the recent scientific advances which shed light on the biologic significance, physiology, expression and regulation of aromatase in breast tissue. Inhibition of aromatase, the terminal step in estrogen biosynthesis, provides a way of treating hormone-dependent breast cancer in older patients. Aminoglutethimide was the first widely used aromatase inhibitor but had several clinical drawbacks. Newer agents are considerably more selective, more potent, less toxic and easier to use in the clinical setting. This article reviews the clinical data supporting the use of the potent, oral competitive aromatase inhibitors anastrozole, letrozole and vorozole and the irreversible inhibitors 4-OH androstenedione and exemestane. The more potent compounds inhibit both peripheral and intra-tumoral aromatase. We discuss the evidence supporting the notion that aromatase inhibitors lack cross-resistance with antiestrogens and suggest that the newer, more potent compounds may have a particular application in breast cancer treatment in a setting of adaptive hypersensitivity to estrogens. Currently available aromatase inhibitors are safe and effective in the management of hormone-dependent breast cancer in post-menopausal women failing antiestrogen therapy and should now be used before progestational agents. There is abundant evidence to support testing these compounds as first-line hormonal therapy for metastatic breast cancer as well as part of adjuvant regimens in older patients and quite possibly in chemoprevention trials of breast cancer. (+info)Lipoproteins regulate expression of the steroidogenic acute regulatory protein (StAR) in mouse adrenocortical cells. (6/183)
The steroidogenic acute regulatory protein (StAR) is required for the movement of cholesterol from the outer to the inner mitochondrial membrane, the site of cholesterol side chain cleavage. Here we describe a novel form of regulation of StAR gene expression in steroidogenic cells. Treatment of Y-1 BS1 adrenocortical cells with either low density lipoprotein (LDL) or high density lipoprotein (HDL) increases expression of endogenous StAR mRNA and protein in a dose-dependent manner. Induction of StAR mRNA by lipoprotein requires basal cAMP-dependent protein kinase, since the inhibitor, R(p)-8-Br-cAMP, inhibited induction of StAR protein by LDL. Likewise, basal StAR expression or LDL induction of StAR protein was not detectable in Y-1 kin-8 cells which are deficient in cAMP-dependent protein kinase. Aminoglutethimide and ketoconazole were used to determine if side chain cleavage of lipoprotein-derived cholesterol is required for induction of StAR mRNA. Treatment with either drug alone induced StAR mRNA expression 1.5-3-fold, while induction of StAR in cells treated with either drug plus LDL, was equal to, or greater than, induction seen with either agent alone, suggesting that lipoprotein does not regulate StAR via generation of an oxysterol intermediate. Both LDL and HDL increased expression of a mouse -966 StAR promoter-reporter construct 1.5-2.5-fold, indicating that regulation occurs at the level of transcription. In contrast, neither lipoprotein was able to induce transcription from a -966 StAR promoter in which the steroidogenic factor-1 site at -135 was abolished, indicating that regulation of StAR transcription by lipoproteins requires steroidogenic factor-1. The regulation of StAR gene expression by lipoproteins may represent a positive feedback circuit which links cholesterol availability with steroidogenic output. (+info)Contribution of progesterone, follicle stimulating hormone and glucocorticoids in survival of serum-free cultured granulosa cell explants. (7/183)
To investigate the role of progesterone (P4) as a survival factor in quail granulosa cell explants, P4 content was determined under various conditions and correlated with apoptotic indexes (AIs) evaluated by 2',6'-diamidino-2-phenylindole (DAPI)-staining. Analysis of serum-free cultures from 24 to 96 h shows decreased P4 levels in the medium paralleled by increasing AI. Inhibiting apoptosis by gonadotropic support (FSH, 100 ng/ml) stimulates a 3-fold increase of the P4 level in the medium (83.49+/-8.69 vs 26.31+/-1.61 ng/ml in serum-free controls) together with a significant decrease in AI from 8.81+/-1.06% in serum-free controls to 3.50+/-0.72%. Substantial evidence for P4 as an autocrine/paracrine survival factor can be inferred from experiments with aminoglutethimide (AG, 1 mM) and RU486 (20 microM). Blocking P4 synthesis by AG causes a 2-fold increase in apoptosis from 6.08+/-0.67% in serum-free controls to 12.53+/-1.60%. Blocking P4 receptors by RU486 causes a similar increase in AI (3.02+/-0.98% in serum-free controls to 17.07+/-3.20%) and about a 50% decrease in P4. The effect of RU486 could be attenuated by exogenous P4 but not by dexamethasone indicating selective binding of P4 to the progesterone receptor. Dexamethasone treatment promotes survival without affecting P4 levels. In further support of an autocrine/paracrine action for P4 in the granulosa cells, both the A and B form of the avian P4 receptor (PR) are identified in vivo and in vitro by Western blotting. Exogenous administration of P4 only affects survival when endogenous P4 synthesis is blocked or after 48 h of serum-free culture when endogenous P4 production is very low. Because FSH also affects survival when its stimulatory effect on P4 synthesis is blocked by AG (AI decrease from 6.08+/-0.67% in serum-free controls to 1.64+/-0.71% in FSH+AG treated) it is proposed that (1) P4 is an autocrine/paracrine survival factor in the preovulatory granulosa and (2) FSH mediates both P4-dependent and P4-independent survival pathways. (+info)Aromatase inhibition by an 11,13-dihydroderivative of a sesquiterpene lactone. (8/183)
Compounds that inhibit aromatase activity are used for the treatment of breast cancer. A group of sesquiterpene lactones inhibit aromatase activity and also exert cytotoxicity through their reactive alpha-methylene-gamma-lactone group. To synthesize sesquiterpene lactones with greater specificity for aromatase inhibition and lower cytotoxicity, we chemically reduced the alpha-methylene-gamma-lactone group in the active aromatase inhibitor 10-epi-8-deoxycumambrin B (compound 1), to obtain the new compound 11betaH,13-dihydro-10-epi-8-deoxycumambrin B (compound 2). Reduction of the alpha-methylene-gamma-lactone group abrogated the cytotoxic activity of compound 1 against the JEG-3, HeLa, and COS-7 cell lines. Compound 2 had higher aromatase inhibitory activity than compound 1 (IC(50) = 2 +/- 0.5 microM versus 7 +/- 0.5 microM, K(i) = 1.5 microM versus 4.0 microM) and was a more potent type II ligand to the heme iron present in the cytochrome P450(arom) active site. Compound 2 inhibited aromatase activity in JEG-3 cells in a comparable manner to the inhibitor aminoglutethimide (AG) used clinically for the treatment of breast cancer. Additionally, compound 2 inhibited androstenedione-induced uterine hypertrophy in sexually immature mice (41% of uterine weight suppression for compound 2 versus 51% for AG). We conclude that the anti-aromatase activity of sesquiterpene lactones does not depend on the presence of the highly reactive alpha-methylene-gamma-lactone group, whereas their cytotoxicity does. These findings may facilitate the development of safer agents for breast cancer therapy. (+info)Aminoglutethimide prostate - Buy aminoglutethimide online
Aminoglutethimide - Wikipedia
Aminoglutethimide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Aminoglutethimide: a side-effect turned to therapeutic advantage | Postgraduate Medical Journal
Cytadren (Aminoglutethimide) Oral: Uses, Dosage & Side Effects
Cytadren (Aminoglutethimide) - Regrowth. Your Source Of Hair News
AMINOGLUTETHIMIDE | SelfDecode | Genome Analysis
Adrenal Steroid Levels in Castrated Men with Prostatic Carcinoma Treated with Aminoglutethimide Plus Hydrocortisone<...
A randomized trial comparing surgical adrenalectomy with aminoglutethimide plus hydrocortisone in women with advanced breast...
Steroid hormone metabolism - Figure 2
A Phase II Trial of Early Medical Adrenalectomy for D0.5 Prostate Cancer - Full Text View - ClinicalTrials.gov
Breast cancer pills - Stock Image M625/1017 - Science Photo Library
Design, synthesis, and evaluation of 4-(4-aminobenzyl)-2-oxazolidinones as novel inhibitors of the cytochrome P-450 enzyme...
Where to buy prednisolone acetate
RNoN successfully tests Kongsbergs one-shot mine disposal weapon system - Naval Technology
DECADRON - Pulmonology Advisor
Plus it
Monthly rates of cell cycle of rat adrenal cells in administration of 0,9% NaCl solution, lactoprotein with sorbitol or haes-lx...
Comparación de precios para Hydrocortisone (anusol hc) - Descuentos, precio y cupones | PharmacyChecker.com
Gentaur Molecular :BioBasic \ Hydrocortisone \ HB0506
Hydrocortisone in Punjabi ਵਰਤੋਂ, ਖੁਰਾਕ, ਬੁਰੇ ਪ੍ਰਭਾਵ, ਲਾਭ, ਪਰਸਪਰ ਪ੍ਰਭਾਵ ਅਤੇ ਚੇਤਾਵਨੀ
The EPA National Library Catalog | EPA National Library Network | US EPA
DR. MOINDI STEPHEN KIBET
KAKEN - Research Projects | Relationship between antiandrogen withdrawal syndrome and genetic alterations of the androgen...
Self-reported cognitive functioning in postmenopausal breast cancer patients before and during endocrine treatment: findings...
Jadit Hydrocortisone - Buclosamide - Aventis
My 11 month old daughter has been using Hydrocortisone 0.5%
Hydrocortisone
DE69738406T2 - Improvements in or on contrast agents - Google Patents
Aldosterone-Producing Adrenocortical CarcinomaPreoperative Recognition and Course in Three Cases | Annals of Internal Medicine ...
Audio Video Revolution Forum - Hannah Montana/Miley Cyrus 3D Concert Coming to TV in HD
SYNERGISTIC TREATMENT OF CELLS THAT EXPRESS EPHA2 AND ERBB2 - Patent application
SPHINGO-GUANIDINES AND THEIR USE AS INHIBITORS OF SPHINGOSINE KINASE - Patent application
Hydrocortisone 1% In Absorbase Side Effects in Detail - Drugs.com
Diamond Eternity Ring in 18ct Gold - bouf.com
BMI Affects Aromatase Inhibitor-Linked Estrogen Suppression - MPR
Glaxon Alpha 365 - Male Optimization Supplement - Tiger Fitness
Hydrocortisone:Should it be avoided? - AnabolicMinds.com
Zymox Otic | Free Shipping* | EntirelyPets
theophylline SR 24 hr Tab Information - Drugs and Treatments - MedHelp
theophylline Oral Soln Information - Drugs and Treatments - MedHelp
Plus it
Ferndale laboratories inc can be greatly linked with the background of lidocaine hcl - hydrocortisone acetate with aloe
Biocidan Hydrocortisone (Cethexonium; Hydrocortisone Acetate) Sanofi-Aventis
What You Should Know About Taking Hydrocortisone Topical when pregnant, nursing, or administering to children or adults over 60
Hydrocortisone butyrate (JP15/USP) | C25H36O6 | ChemSpider
Where do selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) now fit into breast cancer treatment...
Short-term Effects of Aromatase Inhibition in Obese Men - Tabular View - ClinicalTrials.gov
Tumor Library - Case Detail - Metastatic breast carcinoma - Pelvis - Photograph
Tumor Library - Case Detail - Metastatic breast carcinoma - Pelvis - Photograph
Hydrocortisone/urea topical Side Effects in Detail - Drugs.com
Side effects of using hydrocortisone
ইনজেকশন, Hydrocortisone সোডিয়াম Succinate জন্য ইনজেকশন 100mg জন্য হাইড্রোকোরিসিসন পাউডার
Aminoglutethimide
... is the generic name of the drug and its INN, USAN, and BAN, while aminoglutéthimide is its DCF and ... Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been ... ISBN 978-1-56363-429-1. Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP (July 2007). "Aminoglutethimide-induced protein ...
Margo Cohen
Cash, Ralph; Brough, A. Joseph; Margo, N.P.Cohen; Satoh, Paul S. (1967). "Aminoglutethimide as an inhibitor of adrenal ... Cohen, Margo P. (1968). "Aminoglutethimide inhibition of adrenal desmolase activity". Proc Soc Exp Biol Med. 127 (4): 1086-1090 ...
Glutethimide
Aminoglutethimide Piperidione Methyprylone Pyrithyldione Barceloux DG (2012). Medical Toxicology of Drug Abuse: Synthesized ...
Depressant
Piperidinediones inclide Glutethimide, Methyprylon, Pyrithyldione, Glutarimide, and Aminoglutethimide. The first 3, ( ...
Non steroidal aromatase inhibitors
Aminoglutethimide has an oral administration and a usual dosage range between 250 and 100 mg/day. The drug has good oral ... Aminoglutethimide is an NSAIs and therefore inhibits aromatase among other biosynthesis and is for example used to treat ... Aminoglutethimide has a good distribution around the body and is partly metabolized in the liver by acetylation. The ... In 1960 aminoglutethimide was marketed as an anticonvulsant. Later in 1963, a doctor at the Sinai Hospital in Detroit ...
Antiandrogen
These drugs include aminoglutethimide, ketoconazole, and abiraterone acetate. Aminoglutethimide inhibits cholesterol side-chain ... The earlier androgen synthesis inhibitors aminoglutethimide and ketoconazole have only limitedly been used in the treatment of ... The androgen synthesis inhibitors aminoglutethimide and ketoconazole were first marketed in 1960 and 1977, respectively, and ... These include, to varying extents, cyproterone acetate, flutamide, nilutamide, bicalutamide, aminoglutethimide, and ...
Mitotane
Analogues of mitotane include aminoglutethimide, amphenone B, and metyrapone. Mitotane was introduced in 1960 for the treatment ...
Tamoxifen
The aromatase inhibitor aminoglutethimide induces the metabolism of tamoxifen. Conversely, the aromatase inhibitor letrozole ...
Metyrapone
Analogues of metyrapone include aminoglutethimide, amphenone B, and mitotane. Metyrapone has been found in early human trials ...
Cholesterol side-chain cleavage enzyme
... inhibitors include aminoglutethimide, ketoconazole, and mitotane, among others. ...
N-acetyltransferase
... aminoglutethimide, and sulfamethazine. NAT2 is involved in the metabolism of xenobiotics, which can lead to both the ...
Management of prostate cancer
Ketoconazole can cause liver damage with prolonged use, and aminoglutethimide can cause skin rashes. When hormonal treatment is ... Medications that block the production of adrenal androgens such as DHEA include ketoconazole and aminoglutethimide. Because the ...
Rogletimide
This makes it potentially useful in the treatment of breast cancer, and with fewer side effects than aminoglutethimide, but its ... MacNeill FA, Jones AL, Jacobs S, Lønning PE, Powles TJ, Dowsett M (October 1992). "The influence of aminoglutethimide and its ... but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and ...
Hormonal therapy (oncology)
Aminoglutethimide inhibits both aromatase and other enzymes critical for steroid hormone synthesis in the adrenal glands. It ...
Ketoconazole
Other steroidogenesis inhibitors besides ketoconazole and levoketoconazole include the nonsteroidal compound aminoglutethimide ...
Antiglucocorticoid
... and aminoglutethimide. They are used to treat Cushing's syndrome. Antiglucocorticoids could be effective antidepressants for a ...
Aromatase inhibitor
... s (AIs) include: Aminoglutethimide (Elipten, Cytadren, Orimeten) Testolactone (Teslac) Anastrozole (Arimidex ...
Medroxyprogesterone acetate
The combination of MPA with aminoglutethimide to treat metastases from breast cancer has been associated with an increase in ...
List of antiandrogens
Abiraterone acetate Ketoconazole Seviteronel Aminoglutethimide Alfatradiol Dutasteride Epristeride Finasteride Saw palmetto ...
Medical uses of bicalutamide
In the past, surgical adrenalectomy and early androgen biosynthesis inhibitors like ketoconazole and aminoglutethimide were ... However, adrenalectomy is an invasive procedure with high morbidity, ketoconazole and aminoglutethimide have relatively high ...
List of drugs banned by the World Anti-Doping Agency
... aminoglutethimide, exemestane, formestane, and testolactone are banned. Selective estrogen receptor modulators, including ...
Steroidogenesis inhibitor
Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1) inhibitors such as aminoglutethimide, ketoconazole, and mitotane ... Aromatase inhibitors (AIs) such as aminoglutethimide, anastrozole, exemestane, letrozole, and testolactone inhibit the ...
Steroidal aromatase inhibitor
... proven with the blockade of aminoglutethimide (AG, known to block P450-mediated enzymes. Harry Brodie, a chemist, joined the ...
Glucocorticoid
List of corticosteroids List of corticosteroid cyclic ketals List of corticosteroid esters Aminoglutethimide blocks ...
Anticorticotropin
... and aminoglutethimide, have corticotropic or procorticotropic effects. Anticorticotropins are analogous to antigonadotropins ...
List of MeSH codes (D03)
... aminoglutethimide MeSH D03.383.621.808.800 - thalidomide MeSH D03.383.621.808.930 - triacetoneamine-n-oxyl MeSH D03.383.621.815 ...
Nonsteroidal
... aminoglutethimide, fadrozole, finrozole, letrozole, liarozole, norendoxifen, rogletimide (pyridoglutethimide), vorozole Other ... steroidogenesis inhibitors: aminoglutethimide, ketoconazole, orteronel, seviteronel, others Miscellaneous: tanaproget ( ...
Amphenone B
Aminoglutethimide (3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione), which was originally introduced as an anticonvulsant in 1960 ...
Anticorticosteroid
They include: Antiglucocorticoids - e.g., mifepristone, ketoconazole, aminoglutethimide Antimineralocorticoids - e.g., ...
Neurosteroidogenesis inhibitor
Inhibitors of cholesterol side-chain cleavage enzyme (P450scc), such as aminoglutethimide and ketoconazole, may block ...
Aminoglutethimide for the treatment of advanced postmenopausal breast cancer. - Department of Oncology
Aminoglutethimide is an effective endocrine therapy in advanced postmenopausal breast cancer, particularly for bone deposits. ... Two hundred and thirteen unselected postmenopausal women with advanced breast cancer were treated with aminoglutethimide and ... Aminoglutethimide for the treatment of advanced postmenopausal breast cancer. Harris AL., Powles TJ., Smith IE., Coombes RC., ... Two hundred and thirteen unselected postmenopausal women with advanced breast cancer were treated with aminoglutethimide and ...
A-Z Drug Index for Prescription and OTC Medications
Erythroderma (Generalized Exfoliative Dermatitis) Treatment & Management: Medical Care, Consultations, Diet
Exfoliative dermatitis (ED) is a definitive term that refers to a scaling erythematous dermatitis involving 90% or more of the cutaneous surface. Exfoliative dermatitis is characterized by erythema and scaling involving the skins surface and often obscures the primary lesions that are important clues to understanding the evolution of the dis...
Transgender hormone therapy - Wikipedia
Male Breast Cancer Treatment (PDQ®)-Health Professional Version - NCI
Medroxyprogesterone: MedlinePlus Drug Information
Truxophyllin Advanced Patient Information - Drugs.com
DailyMed - ZILRETTA- triamcinolone acetonide extended-release injectable suspension kit
Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. - MRC Weatherall...
When aminoglutethimide is used at the conventional daily dose of 1000 mg in combination with 40 mg of hydrocortisone these ... In the current study it was found that with twice daily treatment at the low dose of 125 mg aminoglutethimide plus 20 mg ... Aminoglutethimide is effective in the treatment of breast cancer in postmenopausal patients as a result of its inhibition of ... Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. ...
The Prohibited List | World Anti Doping Agency
SEER*Rx Interactive Antineoplastic Drugs Database
Fast Five Quiz: Key Aspects of Hypothyroidism
Légis Québec
Aromatase Inhibitors | GreenMedInfo | Pharmacological Action
The Steroid Interviews - Professional Bodybuilding
Retapamulin: Uses, Interactions, Mechanism of Action | DrugBank Online
Dexacort Phosphate in Turbinaire - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Annexes nationales de médicaments - ANORP
Proposition 65 List of Elabscience Chemicals
US Patent for Methods of treatment using anti-ErbB antibody-maytansinoid conjugates Patent (Patent # 7,097,840 issued August...
Patent 2830806 Summary - Canadian Patents Database
Veröffentlichungen | Max-Planck-Institut für Dynamik komplexer technischer Systeme
Medroxyprogesterone Injection: MedlinePlus Drug Information
Deflachek 30mg Tablet 6'S - Buy Medicines online at Best Price from Netmeds.com
RAYOS Dosage & Rx Info | Uses, Side Effects
Mazzocchi G - Search Results - PubMed
Kenalog-10, Kenalog-40 (triamcinolone acetonide injectable suspension) dosing, indications, interactions, adverse effects, and...
Status of adjuvant endocrine therapy for breast cancer | Breast Cancer Research | Full Text
Aminoglutethimide (AG) was the first AI to be developed for clinical use [34-36] and showed benefit initially in advanced ... Smith IE, Fitzharris BM, McKinna JA, Fahmy DR, Nash AG, Neville AM, Gazet JC, Ford HT, Powles TJ: Aminoglutethimide in ... Lipton A, Santen RJ: Proceedings: medical adrenalectomy using Aminoglutethimide and Dexamethasone in advanced breast cancer. ... Adjuvant aminoglutethimide for postmenopausal patients with primary breast cancer: analysis at 8 years. J Clin Oncol. 1992, 10 ...
Cytadren1
- Be sure to mention aminoglutethimide (Cytadren). (medlineplus.gov)
Postmenopausal breast cancer3
- Aminoglutethimide for the treatment of advanced postmenopausal breast cancer. (ox.ac.uk)
- Aminoglutethimide is an effective endocrine therapy in advanced postmenopausal breast cancer, particularly for bone deposits. (ox.ac.uk)
- Low-dose aminoglutethimide in postmenopausal breast cancer: effects on adrenal and thyroid hormone secretion. (ox.ac.uk)
Hydrocortisone5
- Two hundred and thirteen unselected postmenopausal women with advanced breast cancer were treated with aminoglutethimide and hydrocortisone. (ox.ac.uk)
- When aminoglutethimide is used at the conventional daily dose of 1000 mg in combination with 40 mg of hydrocortisone these effects can result in clinically significant hypothyroidism and increases in the serum levels of oestrone in response to stimulation of adrenocorticotropic hormone (ACTH). (ox.ac.uk)
- In the current study it was found that with twice daily treatment at the low dose of 125 mg aminoglutethimide plus 20 mg hydrocortisone there was no significant increase in oestrone levels after ACTH stimulation. (ox.ac.uk)
- Combining hydrocortisone with either aminoglutethimide or ketoconazole may be an effective treatment for prostate cancer. (drugpatentwatch.com)
- PURPOSE: Phase II trial to study the effectiveness of combining hydrocortisone with either aminoglutethimide or ketoconazole in treating patients who have localized stage IV prostate cancer. (drugpatentwatch.com)
Hormones1
- Drugs such as aminoglutethimide or ketoconazole may stop the adrenal glands from producing hormones. (drugpatentwatch.com)
Inhibition1
- Aminoglutethimide is effective in the treatment of breast cancer in postmenopausal patients as a result of its inhibition of aromatase. (ox.ac.uk)
Drug2
Ketoconazole5
- The goal is to inhibit the enzymes responsible for cortisol synthesis with adrenal enzyme inhibitors, such as metyrapone, aminoglutethimide, and ketoconazole. (medscape.com)
- These drugs include ketoconazole, aminoglutethimide, metyrapone, mitotane, and etomidate, and they exert their effect by inhibition of steroidogenic enzymes such as 11β-hydroxylase and 17α-hydroxylase. (scitechnol.com)
- Ketoconazole, aminoglutethimide, and abiraterone acetate (Zytiga) are three androgen synthesis inhibitors that are approved in the United States. (arizonaoncology.com)
- The failure of aminoglutethimide to lower ASD levels and drug toxicity as a result of high aminoglutethimide levels are two factors that lead clinicians from aminoglutethimide to ketoconazole for adrenal androgen synthesis blockade [ 15 ]. (ijbs.com)
- Aminoglutethimide has been used but it has greater toxicity than ketoconazole but similar response rates. (cancerstreatment.com)
Androstenedione2
Aromatase inhibitor4
- Endocrine effects of low dose aminoglutethimide as an aromatase inhibitor in the treatment of breast cancer. (ox.ac.uk)
- 6. In vivo and in vitro pharmacological studies of aminoglutethimide as an aromatase inhibitor. (nih.gov)
- 15. Induction of aromatase expression by aminoglutethimide, an aromatase inhibitor that is used to treat breast cancer in postmenopausal women. (nih.gov)
- One in vitro study [4] even noted that chysin is similar in potency and effectiveness to aminoglutethimide, a pharmaceutical aromatase inhibitor used clinically in cases of estrogen-dependent carcinoma. (nutrientjournal.com)
Tamoxifen1
- Combination treatment with tamoxifen and aminoglutethimide in advanced breast cancer. (ox.ac.uk)
Anastrozole2
- Reduced gradually on the advice of the doctor in charge the symptoms that come along with low testosterone this means that without the administration of aromatase inhibitors such as Anastrozole or Aminoglutethimide, estrogenic effects will appear over time in men. (animeconji.org)
- Anastrozole was found to be 200 times more potent than aminoglutethimide and was more than three times more effective than formestane. (stuggigaming.de)
Endocrine2
Cortisol2
- Aminoglutethimide-oral is used to stop the adrenal gland from making too much cortisol and other hormones. (alternativemedicals.com)
- Aminoglutethimide is used to treat Cushing's syndrome, a disease that occurs when the body produces too much cortisol and other hormones. (alternativemedicals.com)
Metyrapone1
- Metyrapone and aminoglutethimide have been the standard therapy, and, when the 2 agents are used in combination, adverse effects may be decreased. (medscape.com)
Adrenal suppression2
- 4. Adrenal suppression with aminoglutethimide. (nih.gov)
- Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression. (clinicaladvisor.com)
Estrogen1
- 2. Preservation of androgen secretion during estrogen suppression with aminoglutethimide in the treatment of metastatic breast carcinoma. (nih.gov)
Drugs3
- Synonyms of aminoglutethimide best drugs to get lean cases our understanding of these effects remains limited. (akrobotics.com)
- Controlling symptoms of enhanced cytotoxic drugs and rosuvastatin were used to be diagnosed with aminoglutethimide: bvz003. (holabar.com)
- Riboflavin is included with other drugs Femara to aminoglutethimide, and with poise, clots after heart surface. (lariberabilbao.com)
Suppression1
- Aminoglutethimide is as effective at 125 mg twice a day without HC in its suppression of oestrogen levels as at 500 mg twice a day with HC, and its use in this form warrants clinical evaluation. (ox.ac.uk)
Concentrations1
- Aminoglutethimide diminishes plasma concentrations of Provera. (buypurchase.org.uk)
ACTH2
- Consistent with this hypothesis, similar effects on adrenal mitochondrial cholesterol were produced by in vivo administration of the cholesterol side-chain cleavage inhibitor, aminoglutethimide, to ACTH-stimulated rats. (nih.gov)
- 17. Influence of ACTH on aminoglutethimide induced reduction of plasma steroids in postmenopausal breast cancer. (nih.gov)
Therapeutic effects1
- That their steroid counterpart from last glaucoma surgery to infection onset, intraocular aminoglutethimide enhance the metabolism of corticosteroids and its therapeutic effects may be reduced. (floridacleanwaternetwork.org)
Cancer2
- Treatment with aminoglutethimide of only four premenopausal breast cancer patients has been reported in which two patients responded. (ox.ac.uk)
- 19. Influence of dexaminoglutethimide, an optical isomer of aminoglutethimide, on the disposition of estrone sulfate in postmenopausal breast cancer patients. (nih.gov)
Testosterone1
- Resumen en inglés Using endothelium-denuded rat aortic rings incubated in Ca2+-free solution, we assessed the ability of testosterone to influence the contractile effect of phenylephrine, and the increase in resting tone (IRT) associated with Ca2+ ability to cross the plasma membrane. (worldwidescience.org)
Blockade1
- 18. Resistance of the ovary to blockade of aromatization with aminoglutethimide. (nih.gov)
Effects2
- Resumen en inglés Purpose: To study the effects of mitomycin-C (MMC) on the corneal endothelium after pterygium surgery. (worldwidescience.org)
- Various products instructions are valuable to me and effects in addition to muscle buy and with aminoglutethimide. (phldnc.com)
Studies1
- 8. Basic studies on aminoglutethimide. (nih.gov)
Administration1
- Resumen en inglés ABSTRACT Influence of long-term palm and corn oil diet supplement administration on rabbit aortic rings vasoconstriction and vasodilatation. (worldwidescience.org)