Mastodynia
Drug Resistance, Bacterial
Drug Resistance, Microbial
Drug Utilization
Hydrogen Peroxide
Detergents
Lipid A
Carotenoids
Saturn
Thermal Conductivity
Plastics
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Body Temperature Regulation
Convection
Transmission of energy or mass by a medium involving movement of the medium itself. The circulatory movement that occurs in a fluid at a nonuniform temperature owing to the variation of its density and the action of gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed; Webster, 10th ed)
Parabens
Metabolic Engineering
Netherlands
Oxo-Acid-Lyases
Plants, Genetically Modified
Genetic Engineering
Plant Proteins
Reagent Kits, Diagnostic
Hospitals, Military
Sensitivity and Specificity
International Cooperation
International Agencies
Internationality
Peptide Synthases
Polyketide Synthases
Peptide Biosynthesis, Nucleic Acid-Independent
Polyketides
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Tyrocidine
An antibiotic mixture produced by Bacillus brevis which may be separated into three components, tyrocidines A, B, and C. It is the major constituent (40-60 per cent) of tyrothricin, gramicidin accounting for the remaining 10-20 per cent active material. It is a topical antimicrobial agent, that is very toxic parenterally.
Streptomyces
Streptococcus pneumoniae
DNA Gyrase
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
DNA, Superhelical
DNA Topoisomerases, Type II
Novobiocin
DNA Topoisomerase IV
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Siloxanes
Dental Impression Materials
Dental Impression Technique
Procedure of producing an imprint or negative likeness of the teeth and/or edentulous areas. Impressions are made in plastic material which becomes hardened or set while in contact with the tissue. They are later filled with plaster of Paris or artificial stone to produce a facsimile of the oral structures present. Impressions may be made of a full complement of teeth, of areas where some teeth have been removed, or in a mouth from which all teeth have been extracted. (Illustrated Dictionary of Dentistry, 1982)
Silicon Dioxide
Polymers
Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. (1/101)
BACKGROUND: Heat shock protein 90 (Hsp90) interacts with and stabilizes several oncogenic protein kinases (e.g., p185(erbB2), p60(v-src), and Raf-1) and is required for the stability and dominant-negative function of mutated p53 protein. Two unrelated antibiotics, geldanamycin and radicicol, bind specifically to an atypical nucleotide-binding pocket of Hsp90, a site that shares homology with the adenosine triphosphate (ATP)-binding domain of bacterial DNA gyrase B. This interaction leads to destabilization of proteins that interact with Hsp90. Since the nucleotide-binding site of gyrase B is targeted by coumarin antibiotics (e.g., novobiocin), we investigated whether these drugs can also interact with Hsp90 and affect its activity. METHODS: We used immobilized novobiocin, geldanamycin, or radicicol to isolate either endogenous Hsp90 from cell lysates or Hsp90 deletion fragments translated in vitro. Effects of the coumarin antibiotics novobiocin, chlorobiocin, and coumermycin A1 on several proteins interacting with Hsp90 were assessed in vitro and in vivo. RESULTS: Hsp90 binding to immobilized novobiocin was competed by soluble coumarins and ATP but not by geldanamycin or radicicol. A carboxy-terminal Hsp90 fragment bound immobilized novobiocin but not immobilized geldanamycin, while a geldanamycin-binding amino-terminal fragment did not bind novobiocin. All three coumarins markedly reduced cellular levels of p185(erbB2), p60(v-src), Raf-1, and mutated p53. Furthermore, novobiocin reduced Raf-1 levels in the spleens of mice treated with the drug. CONCLUSIONS: These coumarin antibiotics, particularly novobiocin, represent a first-generation alternative to other Hsp90-targeting drugs that are not as well tolerated. Novobiocin's unique interaction with Hsp90 identifies an additional site on this protein amenable to pharmacologic interference with small molecules. (+info)Suppression of chromosome segregation defects of Escherichia coli muk mutants by mutations in topoisomerase I. (2/101)
Escherichia coli muk mutants are temperature-sensitive and produce anucleate cells. A spontaneously occurring mutation was found in a DeltamukBkan mutant strain that suppressed the temperature-sensitive phenotype and mapped in or near topA, the gene that encodes topoisomerase I. Previously characterized topA mutations, topA10 and topA66, were found to be general suppressors of muk mutants: they suppressed temperature sensitivity and anucleate cell production of cells containing null or point mutations in mukB and null mutations in mukE or mukF. The suppression correlated with excess negative supercoiling by DNA gyrase, and the gyrase inhibitor, coumermycin, reversed it. Defects in topA allow 99% of cell division events in muk null mutants to proceed without chromosome loss or loss of cell viability. This observation imposes important limitations on models for Muk activity and is consistent with a role for MukBEF in chromosome folding and DNA condensation. (+info)Membrane localization of Raf assists engagement of downstream effectors. (3/101)
We have previously described a small molecule-directed protein dimerization strategy, using coumermycin to juxtapose Raf fusion proteins containing the coumermycin-binding domain GyrB. Oligomerization of cytoplasmically localized Raf-GyrB fusion proteins leads to an increase in the kinase activity of both Raf and its substrate Mek. Surprisingly, more distal targets, such as Erk1 and Erk2, are not activated using this approach. Here we report that coumermycin-induced oligomerization of a membrane-localized Raf-GyrB fusion protein potently activated Erk1 and Erk2, up-regulated Fos protein levels, and induced expression of many immediate-early response genes. Thus, both membrane localization and oligomerization of Raf-GyrB are required to target Raf signals to downstream effectors. The ability to activate the entire Raf signal transduction cascade conditionally, using coumermycin-induced oligomerization, should prove useful for dissecting Raf-mediated effects on gene expression and cellular differentiation. (+info)Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. (4/101)
The biosynthetic gene cluster of the aminocoumarin antibiotic coumermycin A(1) was cloned by screening of a cosmid library of Streptomyces rishiriensis DSM 40489 with heterologous probes from a dTDP-glucose 4,6-dehydratase gene, involved in deoxysugar biosynthesis, and from the aminocoumarin resistance gyrase gene gyrB(r). Sequence analysis of a 30.8-kb region upstream of gyrB(r) revealed the presence of 28 complete open reading frames (ORFs). Fifteen of the identified ORFs showed, on average, 84% identity to corresponding ORFs in the biosynthetic gene cluster of novobiocin, another aminocoumarin antibiotic. Possible functions of 17 ORFs in the biosynthesis of coumermycin A(1) could be assigned by comparison with sequences in GenBank. Experimental proof for the function of the identified gene cluster was provided by an insertional gene inactivation experiment, which resulted in an abolishment of coumermycin A(1) production. (+info)Chimeric VEGFRs are activated by a small-molecule dimerizer and mediate downstream signalling cascades in endothelial cells. (5/101)
Despite much interest in vascular endothelial growth factor (VEGF) and its receptors (VEGFRs -1 and -2), VEGF-induced signalling cascades remain incompletely defined. Attempts to assign individual responses to a particular receptor have used either transfected cell lines, receptor-specific growth factors or antisense oligonucleotides. Such studies have attributed the majority of VEGF-induced responses to activation of VEGFR-2. As a consequence of poor growth factor-induced VEGFR-1 autophosphorylation however, observations from these studies may instead reflect the relative activation of the two receptors. We have generated novel chimeric VEGF receptors in which the dimerization domain of the B subunit of DNA gyrase is fused to the cytoplasmic domain of VEGFRs -1 and -2. When expressed in porcine aortic endothelial cells, both chimeric VEGFR-1 and -2 autophosphorylate in response to addition of the small-molecule dimerizing agent, coumermycin. Once activated, both receptors induce downstream signalling cascades, exemplified here by the activation of MAPK, PLCgamma and PKB/Akt. Furthermore, we demonstrate that the Y1175 residue of VEGFR-2 is essential for the activation of PLCgamma mediated by this chimeric receptor. In contrast to previous reports which show a limited ability of VEGFR-1 to mediate signalling cascades, we show that once sufficiently activated, VEGFR-1 signals in a similar manner to VEGFR-2 in endothelial cells. (+info)Brachyspira (Serpulina) hyodysenteriae gyrB mutants and interstrain transfer of coumermycin A(1) resistance. (6/101)
To further develop genetic techniques for the enteropathogen Brachyspira hyodysenteriae, the gyrB gene of this spirochete was isolated from a lambdaZAPII library of strain B204 genomic DNA and sequenced. The putative protein encoded by this gene exhibited up to 55% amino acid sequence identity with GyrB proteins of various bacterial species, including other spirochetes. B. hyodysenteriae coumermycin A(1)-resistant (Cn(r)) mutant strains, both spontaneous and UV induced, were isolated by plating B204 cells onto Trypticase soy blood agar plates containing 0.5 microg of coumermycin A(1)/ml. The coumermycin A(1) MICs were 25 to 100 microg/ml for the resistant strains and 0.1 to 0.25 microg/ml for strain B204. Four Cn(r) strains had single nucleotide changes in their gyrB genes, corresponding to GyrB amino acid changes of Gly(78) to Ser (two strains), Gly(78) to Cys, and Thr(166) to Ala. When Cn(r) strain 435A (Gly(78) to Ser) and Cm(r) Km(r) strain SH (DeltaflaA1::cat Deltanox::kan) were cultured together in brain heart infusion broth containing 10% (vol/vol) heat-treated (56 degrees C, 30 min) calf serum, cells resistant to chloramphenicol, coumermycin A(1), and kanamycin could be isolated from the cocultures after overnight incubation, but such cells could not be isolated from monocultures of either strain. Seven Cn(r) Km(r) Cm(r) strains were tested and were determined to have resistance genotypes of both strain 435A and strain SH. Cn(r) Km(r) Cm(r) cells could not be isolated when antiserum to the bacteriophage-like agent VSH-1 was added to cocultures, and the numbers of resistant cells increased fivefold when mitomycin C, an inducer of VSH-1 production, was added. These results indicate that coumermycin resistance associated with a gyrB mutation is a useful selection marker for monitoring gene exchange between B. hyodysenteriae cells. Gene transfer readily occurs between B. hyodysenteriae cells in broth culture, a finding with practical importance. VSH-1 is the likely mechanism for gene transfer. (+info)Complementation of a Treponema denticola flgE mutant with a novel coumermycin A1-resistant T. denticola shuttle vector system. (7/101)
By using the mutated gyrB gene from a spontaneous coumermycin A1-resistant Treponema denticola, an Escherichia coli-T. denticola shuttle vector that renders T. denticola resistant to coumermycin was constructed. The complete T. denticola flgE gene was cloned into the shuttle vector pKMCou, and the vector was transformed into the T. denticola ATCC 33520 flgE erythromycin-resistant knockout mutant HL210. The coumermycin-resistant transformants were motile and restored FlgE activity. This complementation system should prove useful in studying the virulence factors of T. denticola and uncultivatible pathogenic spirochetes. (+info)Promoter protection by a transcription factor acting as a local topological homeostat. (8/101)
Binding of the Escherichia coli global transcription factor FIS to the upstream activating sequence (UAS) of stable RNA promoters activates transcription on the outgrowth of cells from stationary phase. Paradoxically, while these promoters require negative supercoiling of DNA for optimal activity, FIS counteracts the increase of negative superhelical density by DNA gyrase. We demonstrate that binding of FIS at the UAS protects the rrnA P1 promoter from inactivation at suboptimal superhelical densities. This effect is correlated with FIS-dependent constraint of writhe and facilitated untwisting of promoter DNA. We infer that FIS maintains stable RNA transcription by stabilizing local writhe in the UAS. These results suggest a novel mechanism of transcriptional regulation by a transcription factor acting as a local topological homeostat. (+info)
Coumermycin A1 - TOKU-E
Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7 - Fingerprint
- NYU Scholars
Interaction of coumarin derivatives with human serum albumin: investigation by fluorescence spectroscopic technique and...
Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin...
Vanco 00110 : CDS information --- DoBISCUIT
Novobiocin - Wikipedia
UniProt: V6KJ36 STRRC
pF12K RM Flexi Vector
sbmC - DNA gyrase inhibitor - Escherichia coli (strain K12) - sbmC gene & protein
MaxSignal® Oxolinic Acid ELISA Kit | PerkinElmer
A 990581 - AdisInsight
FUN 12 | SSGCID
EngineerZone
Diamond Publications - Search Results
DNA supercoiling
High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity. | nanomedicines.org
Publications | Multiple Sclerosis UW Rehabilitation Research
RCSB PDB - 4GGL: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and...
Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology<...
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines | proLékaře.cz
RCSB PDB
- 4HYM: Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided...
What is DNA gyrase? | Reference.com
DNA reverse gyrase: Definition with DNA reverse gyrase Pictures and Photos
CL-promoted DNA cleavage mediated by gyrase occurs at s | Open-i
DNA gyrase|Targetmol
Sparrho | Development of Increased Oxolinic Acid-resistance in Burkho
MORTALITET DOJENČADI | REPEFZG
Big Data by Gabriella Adi Nugraha on Prezi
DNA gyrase | definition of DNA gyrase by Medical dictionary
Leicester Research Archive: DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs
Medley
SAUSA300 0005 - AureoWiki
Energy-saving bacteria resist antibiotics
emmedonline - Fluroquinolones
Coumermycin A1
"Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology Advances. 27 (6): 1006- ...
Clorobiocin
Heide L (2009). "Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins". Biotechnology ...
Topoisomerase inhibitor
Aminocoumarins (coumarins and simocyclinones) and quinolones are the two main classes of TopII inhibitors that function as ... Simocyclinones are another class of TopII antibiotics but differ from aminocoumarins in that they are composed of both ... aminocoumarins and a polyketide element. They also inhibit DNA gyrase's ability to bind to DNA instead of inhibiting ATPase ...
Novobiocin
Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved ... The overlap of the coumarin and ATP-binding sites is consistent with aminocoumarins being competitive inhibitors of the ATPase ...
List of MeSH codes (D03)
... aminocoumarins MeSH D03.438.150.446.139.500 - novobiocin MeSH D03.438.150.446.280 - chromonar MeSH D03.438.150.446.350 - ... aminocoumarins MeSH D03.830.219.446.139.500 - novobiocin MeSH D03.830.219.446.280 - chromonar MeSH D03.830.219.446.350 - ...
DNA gyrase
Two classes of antibiotics that inhibit gyrase are: The aminocoumarins (including novobiocin and Coumermycin A1), which work by ...
Rifaximin
... is a low cost drug.[7] In the United States, Salix Pharmaceuticals holds a US Patent for rifaximin and markets the drug under the name Xifaxan.[17][18] In addition to receiving FDA approval for traveler's diarrhea and (marketing approved for)[18] hepatic encephalopathy, rifaximin received FDA approval for IBS in May 2015.[19] No generic formulation is available in the US and none has appeared due to the fact that the FDA approval process was ongoing. If rifaximin receives full FDA approval for hepatic encephalopathy it is likely that Salix will maintain marketing exclusivity and be protected from generic formulations until March 24, 2017.[18] Rifaximin is approved in 33 countries for GI disorders.[20][21] On August 13, 2013, Health Canada issued a Notice of Compliance to Salix Pharmaceuticals Inc. for the drug product Zaxine.[22] In India it is available under the brand names Ciboz and Xifapill.[citation needed] In Russia and Ukraine the drug is sold under the name Alfa Normix ...
Quinolone antibiotic
Although not formally a quinolone, nalidixic acid is considered the first quinolone drug. It was introduced in 1962 for treatment of urinary tract infections in humans.[70] Nalidixic acid was discovered by George Lesher and coworkers in a distillate during an attempt at chloroquine synthesis.[71] Nalidixic acid is thus considered to be the predecessor of all members of the quinolone family, including the second, third and fourth generations commonly known as fluoroquinolones. Since the introduction of nalidixic acid in 1962, more than 10,000 analogs have been synthesized, but only a handful have found their way into clinical practice. The first generation also included other quinolone drugs, such as pipemidic acid, oxolinic acid, and cinoxacin, which were introduced in the 1970s. They proved to be only marginal improvements over nalidixic acid.[72] These drugs were widely used as a first line treatment for many infections, including very commons ones like acute sinusitis, acute bronchitis, and ...
Metronidazole
... is widely used to treat infections of Giardia in dogs, cats, and other companion animals, although it does not reliably clear infection with this organism and is being supplanted by fenbendazole for this purpose in dogs and cats.[53] It is also used for the management of chronic inflammatory bowel disease in cats and dogs.[54] Another common usage is the treatment of systemic and/or gastrointestinal clostridial infections in horses. Metronidazole is used in the aquarium hobby to treat ornamental fish and as a broad-spectrum treatment for bacterial and protozoan infections in reptiles and amphibians. In general, the veterinary community may use metronidazole for any potentially susceptible anaerobic infection. The U.S. Food and Drug Administration (FDA) suggests it only be used when necessary because it has been shown to be carcinogenic in mice and rats, as well as to prevent antimicrobial resistance.[55][56] ...
Sparfloxacin
In a review of 2081 adult patients participating in a Phase III clinical trial of sparfloxacin in community-acquired, lower respiratory tract infections, sparfloxacin (200 or 400 mg loading dose then 100 or 200 mg daily; i.e. 200/100 mg and 400/200 mg) had a similar incidence of adverse events as the comparator agents (Rubinstein, 1996). The overall rates of drug-related adverse reactions for sparfloxacin 400/200 mg versus comparators and 200/100 mg versus the comparator (amoxicillin/clavulanic acid) were 13.7 versus 17.7%, and 9.5 versus 13.2%, respectively. However, many of these reported reactions were very minor; discontinua- tion of the antibacterial agent because of drug-related adverse reactions occurred in 1.6 versus 1.6%, and 1) versus 1.1%, respectively. Adverse reactions affecting the nervous system were reported in 5.7% of the sparfloxacin group, with insomnia and other sleep disorders the most common events ...
Ciprofloxacin
... is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.[2]. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in ...
Trimethoprim
... (TMP) is an antibiotic used mainly in the treatment of bladder infections.[1] Other uses include for middle ear infections and travelers' diarrhea.[1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.[1][2] It is taken by mouth.[1] Common side effects include nausea, changes in taste, and rash.[1] Rarely it may result in blood problems such as not enough platelets or white blood cells.[1] May cause sun sensitivity.[1] There is evidence of potential harm during pregnancy in some animals but not humans.[3] It works by blocking folate metabolism via dihydrofolate reductase in some bacteria which results in their death.[1] Trimethoprim was first used in 1962.[4] It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system.[5] It is available as a generic medication and is not very expensive.[6] In the United States, ten days of treatment costs about $21.[1] ...
Photochemical reactions of 7-aminocoumarins. 10. Reaction of 3-iodo-4-methyl-7-diethylaminocoumarin with heteroaromatic...
US 2013/0274213 A1 - Glycosylated Aminocoumarins And Methods Of Preparing And Uses Of Same -
The Lens - Free & Open Patent and...
Antioxidant activity and protective role on protein glycation of synthetic aminocoumarins
Complex Enzymes In Microbial Natural Product Biosynthesis Part B Polyketides Aminocoumarins And Carbohydrates 2009
... by Freda ... Complex Enzymes In Microbial Natural Product Biosynthesis Part B Polyketides Aminocoumarins And Carbohydrates 2009. Mickey ... Alongside David works his complex enzymes in microbial natural product biosynthesis part b polyketides aminocoumarins and ... Responding a complex enzymes in microbial natural product biosynthesis part b polyketides aminocoumarins problem AND BOOK ...
GAO-11-801, Antibiotic Resistance: Agencies Have Made Limited Progress Addressing Antibiotic Use in Animals
Patente WO1993007086A1 - Bleaching compositions - Google Patentes
Patent US3922435 - Heat transfer label - Google Patents
Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
The Raf-1 serine/threonine kinase is a key component of the MAP kinase cascade, regulating both proliferation and commitment to cell fate. Raf activation is stimulated following its translocation to the plasma membrane, a process that ordinarily requires interaction with the membrane-localized GTPas …
New way to fight drug-resistant bacteria - UPI.com
By modifying aminocoumarins, the researchers said they hope to develop more effective inhibitors, turning them into more potent ... Aminocoumarins are inhibitors of bacterial enzymes that untwist and unknot DNA. Without these enzymes, bacteria cannot ... The researchers said they can generate potentially hundreds of variants of antibiotics called aminocoumarins. ...
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Review Articles | Universität Tübingen
Saleh O, Haagen Y, Seeger K, Heide L (2009) Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, ... Li S-M, Heide L (2004) Functional analysis of biosynthetic genes of aminocoumarins and production of hybrid antibiotics; Curr ... Heide L (2009) Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins. Biotechnol Adv 27: 1006 ... Heide L (2009) Aminocoumarins: Mutasynthesis, chemoenzymatic synthesis and metabolic engineering. Meth Enzymol. 459: 437-455 ...
Coumermycin A1 - Wikipedia
Clorobiocin - Wikipedia
US6310025B1 - Laundry pretreatment process and bleaching compositions
- Google Patents
CN1195833C - Cleaning products which uses sonic or ultrasonic waves
- Google Patents
Microbiological indoor air quality in an office building in Gliwice, Poland: analysis of the case study | SpringerLink
Bioline International Official Site (site up-dated regularly)
What is Fluorescence Spectroscopy - HORIBA
Toxins | Free Full-Text | Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the...
Frontiers | The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling | Microbiology
Patent US4396524 - Preparation of polysiloxane block polymers and their use as foam inhibitors - Google Patents
Novobiocin - Wikipedia
Patent US4737306 - Layered silicates of limited swelling power, a process for their production ... - Google Patents
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Publikationen | Universität Tübingen
Marine Drugs | Free Full-Text | Biogenetic Relationships of Bioactive Sponge Merotriterpenoids | HTML
Patente US3965024 - Washing agent compositions and washing assistant composition containing ... - Google Patentes
Novel silica-supported molybdic acid (SSMA): an efficient catalyst for the synthesis of new azo dyes | Springer for Research &...
Davies Lab - Publications | Microbiology & Immunology @ UBC
Novobiocin1
- Aminocoumarins : Novobiocin. (comdaisismaper.gq)
Enzymes2
- Aminocoumarins are inhibitors of bacterial enzymes that untwist and unknot DNA. (upi.com)
- Fluoroquinolones (the DNA complex) and aminocoumarins (the ATP site) target these enzymes. (blogspot.com)
Antibiotics3
- The researchers said they can generate potentially hundreds of variants of antibiotics called aminocoumarins. (upi.com)
- By modifying aminocoumarins, the researchers said they hope to develop more effective inhibitors, turning them into more potent antibiotics. (upi.com)
- While there are several classes of antibiotics that are effective against Gram-positive bacteria, the outer membrane (OM) of Gram-negative bacteria excludes high-molecular-weight hydrophobic antibiotics, making these species intrinsically resistant to several classes of antibiotics, including polyketides, aminocoumarins, and macrolides. (infectoforum.net)
Inhibitors1
- [16] The overlap of the coumarin and ATP-binding sites is consistent with aminocoumarins being competitive inhibitors of the ATPase activity. (wikipedia.org)
ATPase1
- Gyrase can be a proven medication target that may either become changed into a poison by little substances (e.g. fluoroquinolones) that stabilize the DNA cleavage condition, or end up being catalytically inhibited by various other little molecules (e.g. aminocoumarins) that inhibit the ATPase response and stop strand passing (15,16). (biodigestor.net)
Antibiotic1
- Heide L (2009) Genetic engineering of antibiotic biosynthesis for the generation of new aminocoumarins. (uni-tuebingen.de)
Derivatives2
- Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones. (edu.pl)
- 28,29 Fluorescent brightening agents are based on diaminostilbene derivatives, triazoles, aminocoumarins, and many other organic compounds and are absorbed by the fibre. (web-foto-media-seo.cz)
Chemistry1
- 7-aminocoumarins in Heterocyclic Chemistry, the power 59! (gurulegalpr.com)
Biology1
- Heide L (2009) The aminocoumarins: biosynthesis and biology. (uni-tuebingen.de)
Family1
- Saleh O, Haagen Y, Seeger K, Heide L (2009) Prenyl transfer to aromatic substrates in the biosynthesis of aminocoumarins, meroterpenoids and phenazines: The ABBA prenyltransferase family. (uni-tuebingen.de)
Studies1
- Interactions of several 7-aminocoumarins with human serum albumin (HSA) were studied by using fluorescence spectroscopic technique and modeling studies. (iisc.ernet.in)
Potential1
- Synthesized aminocoumarins are heterocyclic compounds possessing potential for the treatment of insulin-dependent diabetes mellitus with unexplored anti-glycative action. (conicyt.cl)