Aminocaproic Acid
Aminocaproates
Antifibrinolytic Agents
Aprotinin
Postoperative Hemorrhage
Encyclopedias as Topic
MedlinePlus
Penile Erection
Libido
Penis
Erotica
Effect of phospholipase A2 digestion on the conformation and lysine/fibrinogen binding properties of human lipoprotein[a]. (1/179)
In vitro hydrolysis of human lipoprotein[a] (Lp[a]) by phospholipase A2 (PLA2) decreased the phosphatidylcholine (PC) content by 85%, but increased nonesterified fatty acids 3.2-fold and lysoPC 12.9-fold. PLA2-treated Lp[a] had a decreased molecular weight, increased density, and greater electronegativity on agarose gels. In solution, PLA2-Lp[a] was a monomer, and when assessed by sedimentation velocity it behaved like untreated Lp[a], in that it remained compact in NaCl solutions but assumed the extended form in the presence of 6-amino hexanoic acid, which was shown previously to have an affinity for the apo[a] lysine binding site II (LBS II) comprising kringles IV5-8. We interpreted our findings to indicate that PLA2 digestion had no effect on the reactivity of this site. This conclusion was supported by the results obtained from lysine Sepharose and fibrinogen binding experiments, in the presence and absence of Tween 20, showing that phospholipolysis had no effect on the reactivity of the LBS-II domain. A comparable binding behavior was also exhibited by the free apo[a] derived from each of the two forms of Lp[a]. We did observe a small increase in affinity of PLA2-Lp[a] to lysine Sepharose and attributed it to changes in reactivity of the LBS I domain (kringle IV10) induced by phospholipolysis. In conclusion, the extensive modification of Lp[a] caused by PLA2 digestion had no significant influence on the reactivity of LBS II, which is the domain involved in the binding of apo[a] to fibrinogen and apoB-100. These results also suggest that phospholipids do not play an important role in these interactions. (+info)6-Aminohexanoic acid as a chemical chaperone for apolipoprotein(a). (2/179)
Apolipoprotein (a) (apo(a)) is a component of the atherogenic lipoprotein, Lp(a). The efficiency with which apo(a) escapes the endoplasmic reticulum (ER) and is secreted by the liver is a major determinant of plasma Lp(a) levels. Apo(a) contains a series of domains homologous to plasminogen kringle (K) 4, each of which possesses a potential lysine-binding site. By using primary mouse hepatocytes expressing a 17K4 human apo(a) protein, we found that high concentrations (25-200 mM) of the lysine analog, 6-aminohexanoic acid (6AHA), increased apo(a) secretion 8-14-fold. This was accompanied by a decrease in apo(a) presecretory degradation. 6AHA inhibited accumulation of apo(a) in the ER induced by the proteasome inhibitor, lactacystin. Thus, 6AHA appeared to inhibit degradation by increasing apo(a) export from the ER. Significantly, 6AHA overcame the block in apo(a) secretion induced by the ER glucosidase inhibitor, castanospermine. 6AHA may therefore circumvent the requirement for calnexin and calreticulin interaction in apo(a) secretion. Sucrose gradients and a gel-based folding assay were unable to detect any influence of 6AHA on apo(a) folding. However, non-covalent or small, disulfide-dependent changes in apo(a) conformation would not be detected in these assays. Proline also increased the efficiency of apo(a) secretion. We propose that 6AHA and proline can act as chemical chaperones for apo(a). (+info)Pharmacokinetics of epsilon-aminocaproic acid in patients undergoing aortocoronary bypass surgery. (3/179)
BACKGROUND: Epsilon-aminocaproic acid (EACA) is commonly infused during cardiac surgery using empiric dosing schemes. The authors developed a pharmacokinetic model for EACA elimination in surgical patients, tested whether adjustments for cardiopulmonary bypass (CPB) would improve the model, and then used the model to develop an EACA dosing schedule that would yield nearly constant EACA blood concentrations. METHODS: Consenting patients undergoing elective coronary artery surgery received one of two loading doses of EACA, 30 mg/kg (group I, n = 7) or 100 mg/kg (group II, n = 6) after CPB, or (group III) a 100 mg/kg loading dose before CPB and a 10 mg x kg(-1) x h(-1) maintenance infusion continued for 4 h during and after CPB (n = 7). Two patients with renal failure received EACA in the manner of group III. Blood concentrations of EACA, measured by high-performance liquid chromatography, were subjected to mixed-effects pharmacokinetic modeling. RESULTS: The EACA concentration data were best fit by a model with two compartments and corrections for CPB. The elimination rate constant k10 fell from 0.011 before CPB to 0.0006 during CPB, returning to 0.011 after CPB. V1 increased 3.8 l with CPB and remained at that value thereafter. Cl1 varied from 0.08 l/min before CPB to 0.007 l/min during CPB and 0.13 l/min after CPB. Cl2 increased from 0.09 l/min before CPB to 0.14 l/min during and after CPB. Two patients with renal failure demonstrated markedly reduced clearance. Using their model, the authors predict that an EACA loading infusion of 50 mg/kg given over 20 min and a maintenance infusion of 25 mg x kg(-1) x h(-1) would maintain a nearly constant target concentration of 260 microg/ml. CONCLUSIONS: EACA clearance declines and volume of distribution increases during CPB. The authors' model predicts that more stable perioperative EACA concentrations would be obtained with a smaller loading dose (50 mg/kg given over 20 min) and a more rapid maintenance infusion (25 mg x kg(-1) x h(-1)) than are typically employed. (+info)An integrated study of fibrinogen during blood coagulation. (4/179)
The rate of conversion of fibrinogen (Fg) to the insoluble product fibrin (Fn) is a key factor in hemostasis. We have developed methods to quantitate fibrinopeptides (FPs) and soluble and insoluble Fg/Fn products during the tissue factor induced clotting of whole blood. Significant FPA generation (>50%) occurs prior to visible clotting (4 +/- 0.2 min) coincident with factor XIII activation. At this time Fg is mostly in solution along with high molecular weight cross-linked products. Cross-linking of gamma-chains is virtually complete (5 min) prior to the release of FPB, a process that does not occur until after clot formation. FPB is detected still attached to the beta-chain throughout the time course demonstrating release of only low levels of FPB from the clot. After release of FPB a carboxypeptidase-B-like enzyme removes the carboxyl-terminal arginine resulting exclusively in des-Arg FPB by the 20-min time point. This process is inhibited by epsilon-aminocaproic acid. These results demonstrate that transglutaminase and carboxypeptidase enzymes are activated simultaneously with Fn formation. The initial clot is a composite of Fn I and Fg already displaying gamma-gamma cross-linking prior to the formation of Fn II with Bbeta-chain remaining mostly intact followed by the selective degradation of FPB to des-Arg FPB. (+info)The effect of prophylactic epsilon-aminocaproic acid on bleeding, transfusions, platelet function, and fibrinolysis during coronary artery bypass grafting. (5/179)
BACKGROUND: Antifibrinolytic medications administered before skin incision decrease bleeding after cardiac surgery. Numerous case reports indicate thrombus formation with administration of epsilon-aminocaproic acid (epsilon-ACA). The purpose of this study was to examine the efficacy of epsilon-ACA administered after heparinization but before cardiopulmonary bypass in reducing bleeding and transfusion requirements after primary coronary artery bypass surgery. METHODS: Seventy-four adult patients undergoing primary coronary artery bypass surgery were randomized to receive 125 mg/kg epsilon-ACA followed by an infusion of 12.5 mg x kg(-1) x h(-1) or an equivalent volume of saline. Coagulation studies, thromboelastography, and platelet aggregation tests were performed preoperatively, after bypass, and on the first postoperative day. Mediastinal drainage was recorded during the 24 h after surgery. Homologous blood transfusion triggers were predefined and transfusion amounts were recorded. RESULTS: One patient was excluded for surgical bleeding and five patients were excluded for transfusion against predefined criteria One patient died from a dysrhythmia 2 h postoperatively. Among the remaining 67, the epsilon-ACA group had less mediastinal blood loss during the 24 h after surgery, 529+/-241 ml versus 691+/-286 ml (mean +/- SD), P < 0.05, despite longer cardiopulmonary bypass times and lower platelet counts, P < 0.05. Platelet aggregation was reduced in both groups following cardiopulmonary bypass but did not differ between groups. Homologous blood transfusion was similar between both groups. CONCLUSIONS: Prophylactic administration of epsilon-ACA after heparinization but before cardiopulmonary bypass is of minimal benefit for reducing blood loss postoperatively in patients undergoing primary coronary artery bypass grafting. (+info)The effects of hydrostatic pressure on the conformation of plasminogen. (6/179)
Plasminogen undergoes a large conformational change when it binds 6-aminohexanoate. Using ultraviolet absorption spectroscopy and native PAGE, we show that hydrostatic pressure brings about the same conformational change. The volume change for this conformational change is -33 mL.mol-1. Binding of ligand and hydrostatic pressure both cause the protein to open up to expose surfaces that had previously been buried in the interior. (+info)Intravesicular instillation of E-aminocaproic acid for patients with adenovirus-induced hemorrhagic cystitis. (7/179)
Hemorrhagic cystitis (HC) is a known complication of allogenic BMT. We report a case of a 28-year-old female with CML in chronic phase, which was treated with a matched unrelated donor (MUD) transplant, complicated by hemorrhagic cystitis on day +42 after the transplant. Adenovirus was isolated from the urine and she was treated with ribavirin, 1 g twice a day for 8 days. We report the use of Amicar (E-aminocaproic acid), 2.5 g solution as bladder instillation to treat the intractable hematuria. (+info)Role of the N-terminal region of staphylokinase (SAK): evidence for the participation of the N-terminal region of SAK in the enzyme-substrate complex formation. (8/179)
Staphylokinase (SAK) forms an inactive 1:1 complex with plasminogen (PG), which requires both the conversion of PG to plasmin (Pm) to expose an active site in PG-SAK activator complex and the amino-terminal processing of SAK to expose the positively charged (Lys-11) amino-terminus after removal of the 10 N-terminal amino acid residues from the full length protein. The mechanism by which the N-terminal segment of SAK affects its PG activation capability was investigated by generating SAK mutants, blocked in the native amino-terminal processing site of SAK, and carrying an alteration in the placement of the positively charged amino acid residue, Lys-11, and further studying their interaction with PG, Pm, miniplasmin and kringle structures. A ternary complex formation between PG-SAK PG was observed when an immobilized PG-SAK binary complex interacted with free radiolabelled PG in a sandwich binding experiment. Formation of this ternary complex was inhibited by a lysine analog, 6-aminocaproic acid (EACA), in a concentration dependent manner, suggesting the involvement of lysine binding site(s) in this process. In contrast, EACA did not significantly affect the formation of binary complex formed by native SAK or its mutant derivatives. Furthermore, the binary (activator) complex formed between PG and SAK mutant, PRM3, lacking the N-terminal lysine 11, exhibited 3-4-fold reduced binding with PG, Pm or miniplasmin substrate during ternary complex formation as compared to native SAK. Additionally, activator complex formed with PRM3 failed to activate miniplasminogen and exhibited highly diminished activation of substrate PG. Protein binding studies indicated that it has 3-5-fold reduction in ternary complex formation with miniplasmin but not with the kringle structure. In aggregate, these observations provide experimental evidence for the participation of the N-terminal region of SAK in accession and processing of substrate by the SAK-Pm activator complex to potentiate the PG activation by enhancing and/or stabilizing the interaction of free PG. (+info)Aminocaproic acid is an antifibrinolytic medication, which means it helps to prevent the breakdown of blood clots. It works by blocking plasmin, an enzyme in your body that dissolves blood clots.
This drug is used for the treatment of bleeding conditions due to various causes, such as:
1. Excessive menstrual bleeding (menorrhagia)
2. Bleeding after tooth extraction or surgery
3. Hematuria (blood in urine) due to certain medical procedures or conditions like kidney stones
4. Intracranial hemorrhage (bleeding inside the skull)
5. Hereditary angioedema, a genetic disorder that causes swelling of various parts of the body
Aminocaproic acid is available in oral and injectable forms. Common side effects include nausea, vomiting, diarrhea, and headache. Serious side effects are rare but may include allergic reactions, seizures, or vision changes. It's essential to use this medication under the supervision of a healthcare professional, as improper usage might lead to blood clots, stroke, or other severe complications.
Aminocaproates are a group of chemical compounds that contain an amino group and a carboxylic acid group, as well as a straight or branched alkyl chain with 6-10 carbon atoms. They are often used in medical settings as anti-fibrinolytic agents, which means they help to prevent the breakdown of blood clots.
One example of an aminocaproate is epsilon-aminocaproic acid (EACA), which is a synthetic analogue of the amino acid lysine. EACA works by inhibiting the activation of plasminogen to plasmin, which is an enzyme that breaks down blood clots. By doing so, EACA can help to reduce bleeding and improve clot stability in certain medical conditions, such as hemophilia or following surgery.
Other aminocaproates include tranexamic acid (TXA) and 4-aminoethylbenzoic acid (AEBA), which also have anti-fibrinolytic properties and are used in similar clinical settings. However, it's important to note that these medications can increase the risk of thrombosis (blood clots) if not used properly, so they should only be administered under the close supervision of a healthcare provider.
Antifibrinolytic agents are a class of medications that inhibit the breakdown of blood clots. They work by blocking the action of enzymes called plasminogen activators, which convert plasminogen to plasmin, the main enzyme responsible for breaking down fibrin, a protein that forms the framework of a blood clot.
By preventing the conversion of plasminogen to plasmin, antifibrinolytic agents help to stabilize existing blood clots and prevent their premature dissolution. These medications are often used in clinical settings where excessive bleeding is a concern, such as during or after surgery, childbirth, or trauma.
Examples of antifibrinolytic agents include tranexamic acid, aminocaproic acid, and epsilon-aminocaproic acid. While these medications can be effective in reducing bleeding, they also carry the risk of thromboembolic events, such as deep vein thrombosis or pulmonary embolism, due to their pro-coagulant effects. Therefore, they should be used with caution and only under the close supervision of a healthcare provider.
Tranexamic acid is an antifibrinolytic medication that is used to reduce or prevent bleeding. It works by inhibiting the activation of plasminogen to plasmin, which is a protease that degrades fibrin clots. By preventing the breakdown of blood clots, tranexamic acid helps to reduce bleeding and promote clot formation.
Tranexamic acid is available in various forms, including tablets, capsules, and injectable solutions. It is used in a variety of clinical settings, such as surgery, trauma, and heavy menstrual bleeding. The medication can be taken orally or administered intravenously, depending on the severity of the bleeding and the patient's medical condition.
Common side effects of tranexamic acid include nausea, vomiting, diarrhea, and headache. Less commonly, the medication may cause allergic reactions, visual disturbances, or seizures. It is important to follow the prescribing physician's instructions carefully when taking tranexamic acid to minimize the risk of side effects and ensure its safe and effective use.
Hyphema is defined as the presence of blood in the anterior chamber of the eye, which is the space between the cornea and the iris. This condition usually results from trauma or injury to the eye, but it can also occur due to various medical conditions such as severe eye inflammation, retinal surgery, or blood disorders that affect clotting.
The blood in the anterior chamber can vary in amount, ranging from a few drops to a complete fill, which is called an "eight-ball hyphema." Hyphema can be painful and cause sensitivity to light (photophobia), blurred vision, or even loss of vision if not treated promptly.
Immediate medical attention is necessary for hyphema to prevent complications such as increased intraocular pressure, corneal blood staining, glaucoma, or cataracts. Treatment options may include bed rest, eye drops to reduce inflammation and control intraocular pressure, and sometimes surgery to remove the blood from the anterior chamber.
Aprotinin is a medication that belongs to a class of drugs called serine protease inhibitors. It works by inhibiting the activity of certain enzymes in the body that can cause tissue damage and bleeding. Aprotinin is used in medical procedures such as heart bypass surgery to reduce blood loss and the need for blood transfusions. It is administered intravenously and its use is typically stopped a few days after the surgical procedure.
Aprotinin was first approved for use in the United States in 1993, but its use has been restricted or withdrawn in many countries due to concerns about its safety. In 2006, a study found an increased risk of kidney damage and death associated with the use of aprotinin during heart bypass surgery, leading to its withdrawal from the market in Europe and Canada. However, it is still available for use in the United States under a restricted access program.
It's important to note that the use of aprotinin should be carefully considered and discussed with the healthcare provider, taking into account the potential benefits and risks of the medication.
Surgical blood loss is the amount of blood that is lost during a surgical procedure. It can occur through various routes such as incisions, punctures or during the removal of organs or tissues. The amount of blood loss can vary widely depending on the type and complexity of the surgery being performed.
Surgical blood loss can be classified into three categories:
1. Insensible losses: These are small amounts of blood that are lost through the skin, respiratory tract, or gastrointestinal tract during surgery. They are not usually significant enough to cause any clinical effects.
2. Visible losses: These are larger amounts of blood that can be seen and measured directly during surgery. They may require transfusion or other interventions to prevent hypovolemia (low blood volume) and its complications.
3. Hidden losses: These are internal bleeding that cannot be easily seen or measured during surgery. They can occur in the abdominal cavity, retroperitoneal space, or other areas of the body. They may require further exploration or imaging studies to diagnose and manage.
Surgical blood loss can lead to several complications such as hypovolemia, anemia, coagulopathy (disorders of blood clotting), and organ dysfunction. Therefore, it is essential to monitor and manage surgical blood loss effectively to ensure optimal patient outcomes.
Postoperative hemorrhage is a medical term that refers to bleeding that occurs after a surgical procedure. This condition can range from minor oozing to severe, life-threatening bleeding. Postoperative hemorrhage can occur soon after surgery or even several days later, as the surgical site begins to heal.
The causes of postoperative hemorrhage can vary, but some common factors include:
1. Inadequate hemostasis during surgery: This means that all bleeding was not properly controlled during the procedure, leading to bleeding after surgery.
2. Blood vessel injury: During surgery, blood vessels may be accidentally cut or damaged, causing bleeding after the procedure.
3. Coagulopathy: This is a condition in which the body has difficulty forming blood clots, increasing the risk of postoperative hemorrhage.
4. Use of anticoagulant medications: Medications that prevent blood clots can increase the risk of bleeding after surgery.
5. Infection: An infection at the surgical site can cause inflammation and bleeding.
Symptoms of postoperative hemorrhage may include swelling, pain, warmth, or discoloration around the surgical site, as well as signs of shock such as rapid heartbeat, low blood pressure, and confusion. Treatment for postoperative hemorrhage depends on the severity of the bleeding and may include medications to control bleeding, transfusions of blood products, or additional surgery to stop the bleeding.
Fibrinolysis is the natural process in the body that leads to the dissolution of blood clots. It is a vital part of hemostasis, the process that regulates bleeding and wound healing. Fibrinolysis occurs when plasminogen activators convert plasminogen to plasmin, an enzyme that breaks down fibrin, the insoluble protein mesh that forms the structure of a blood clot. This process helps to prevent excessive clotting and maintains the fluidity of the blood. In medical settings, fibrinolysis can also refer to the therapeutic use of drugs that stimulate this process to dissolve unwanted or harmful blood clots, such as those that cause deep vein thrombosis or pulmonary embolism.
An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.
MedlinePlus is not a medical term, but rather a consumer health website that provides high-quality, accurate, and reliable health information, written in easy-to-understand language. It is produced by the U.S. National Library of Medicine, the world's largest medical library, and is widely recognized as a trusted source of health information.
MedlinePlus offers information on various health topics, including conditions, diseases, tests, treatments, and wellness. It also provides access to drug information, medical dictionary, and encyclopedia, as well as links to clinical trials, medical news, and patient organizations. The website is available in both English and Spanish and can be accessed for free.
Penile erection is a physiological response that involves the engagement of the corpus cavernosum and spongiosum (erectile tissue) of the penis with blood, leading to its stiffness and rigidity. This process is primarily regulated by the autonomic nervous system and is influenced by factors such as sexual arousal, emotional state, and certain medications or medical conditions. A penile erection may also occur in non-sexual situations, such as during sleep (nocturnal penile tumescence) or due to other physical stimuli.
Libido, in medical and psychological terms, refers to a person's overall sexual drive or desire for sexual activity. This term was first introduced by Sigmund Freud in his psychoanalytic theory, where he described it as one of the three components of human personality. Libido is influenced by biological, psychological, and social factors, and can vary significantly among individuals. It's important to note that a low or absent libido does not necessarily indicate an underlying medical issue, but could be a result of various factors such as stress, fatigue, relationship issues, mental health disorders, or hormonal imbalances. If you have concerns about your libido, it is recommended to consult with a healthcare professional for a proper evaluation and guidance.
The penis is a part of the male reproductive and urinary systems. It has three parts: the root, the body, and the glans. The root attaches to the pelvic bone and the body makes up the majority of the free-hanging portion. The glans is the cone-shaped end that protects the urethra, the tube inside the penis that carries urine from the bladder and semen from the testicles.
The penis has a dual function - it acts as a conduit for both urine and semen. During sexual arousal, the penis becomes erect when blood fills two chambers inside its shaft. This process is facilitated by the relaxation of the smooth muscles in the arterial walls and the trappping of blood in the corpora cavernosa. The stiffness of the penis enables sexual intercourse. After ejaculation, or when the sexual arousal passes, the muscles contract and the blood flows out of the penis back into the body, causing it to become flaccid again.
The foreskin, a layer of skin that covers the glans, is sometimes removed in a procedure called circumcision. Circumcision is often performed for religious or cultural reasons, or as a matter of family custom. In some countries, it's also done for medical reasons, such as to treat conditions like phimosis (an inability to retract the foreskin) or balanitis (inflammation of the glans).
It's important to note that any changes in appearance, size, or function of the penis should be evaluated by a healthcare professional, as they could indicate an underlying medical condition.
Erotica is a genre of literature, art, photographs, films, or other media that depicts sexual subject matter in an artistic or aesthetically appealing way. It is intended to evoke sexual feelings and can be used as a means of exploring one's own sexuality or enhancing a romantic relationship. Erotica differs from pornography in that it generally places greater emphasis on the emotional, romantic, or sensual aspects of sexuality, rather than simply focusing on explicit sexual acts.
It is important to note that what may be considered erotic by one person may not be perceived as such by another, and individual preferences can vary widely. Additionally, while some people find erotica to be a healthy and enjoyable form of sexual expression, others may have reservations about its use due to personal, cultural, or religious beliefs.
In medical contexts, the term "erotica" is not typically used, as it is more commonly found in discussions related to art, literature, and media. However, mental health professionals may discuss clients' experiences with erotica as part of a broader conversation about sexuality, relationships, and personal values.
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It can have physical and psychological causes, such as underlying health conditions like diabetes, heart disease, obesity, and mental health issues like stress, anxiety, and depression. ED can also be a side effect of certain medications. Treatment options include lifestyle changes, medication, counseling, and in some cases, surgery.
Aminocaproic acid
Ion-exchange resin
Utako Okamoto
Antifibrinolytic
Angiodysplasia
Tissue-type plasminogen activator
Streptokinase
Caprolactam
Panangipalli Venugopal
Exercise-induced pulmonary hemorrhage
Corneal ulcers in animals
Plastic
Coagulation
Tranexamic acid
Fibrinolysis
Yunnan Baiyao
Nylon-eating bacteria
Hyphema
Aprotinin
Angioedema
Complement deficiency
Sickle cell nephropathy
Thromboelastography
Haemophilia
Glanzmann's thrombasthenia
ATC code B02
Elmer Keiser Bolton
C6H13NO2
List of MeSH codes (D02)
Sumire Uesaka
Aminocaproic acid - Wikipedia
Aminocaproic Acid: MedlinePlus Drug Information
Aminocaproic Acid
AMINOCAPROIC ACID INJECTION, USP
Aminocaproic Acid Reduces Periop Blood Loss in Scoliosis Repair Surgery
MedlinePlus - Search Results for: Aminocaproic Acid
MedlinePlus - Search Results for: ALCLOXA OR AMINOCAPROIC ACID OR SILICON DIOXIDE
Amicar, (aminocaproic acid) dosing, indications, interactions, adverse effects, and more
Local administration of epsilon-aminocaproic acid reduces post-operative blood loss from surgery for closed, Sanders III-IV...
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Aminocaproic Acid
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FDA Drug Shortages
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Amicar4
- Aminocaproic acid (Amicar) is FDA-approved for use in the treatment of acute bleeding due to elevated fibrinolytic activity. (wikipedia.org)
- Examples include aminocaproic acid (Amicar) and tranexamic acid (Cyklokapron). (medicalnewstoday.com)
- Amicar has active ingredients of aminocaproic acid . (ehealthme.com)
- It is based on aminocaproic acid (the active ingredients of Amicar) and Amicar (the brand name). (ehealthme.com)
Tranexamic5
- If bleeding is severe or recurs, an ophthalmologist may give aminocaproic acid or tranexamic acid , which are drugs that hasten blood clotting. (merckmanuals.com)
- Also, Desmopressin (DDAVP), a man-made hormone and antifibrinolytic medicines (tranexamic acid and aminocaproic acid) can be used in conjunction with replacement therapy. (brighthub.com)
- We do not recommend antifibrinolytic agents such as epsilon aminocaproic acid and tranexamic acid to reduce bleeding in the absence of hyperfibrinolysis. (mdcalc.com)
- Antifibrinolytic agents (eg, ε-aminocaproic acid and tranexamic acid) may be useful for mucosal bleeding. (medscape.com)
- Tranexamic acid is an alternative to aminocaproic acid. (medscape.com)
Nucleic Aci1
- Nucleic Acids Res. (mcw.edu)
EACA1
- ε-Aminocaproic acid (EACA) concentrations achieved during cardiopulmonary bypass (CPB) have not been previously reported. (uky.edu)
Hemostasis3
- Aminocaproic Acid Injection is useful in enhancing hemostasis when fibrinolysis contributes to bleeding. (globalrph.com)
- The use of aminocaproic acid for hemostasis is controversial. (medscape.com)
- Aminocaprioc Acid Tablets are useful in enhancing hemostasis when fibrolysis contributes to bleeding. (empr.com)
Inhibition of plasminogen2
- The fibrinolysis-inhibitory effects of aminocaproic acid appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity. (globalrph.com)
- Aminocaproic acid inhibits fibrinolysis via inhibition of plasminogen activator substances and, to a lesser degree, through antiplasmin activity. (medscape.com)
Amino9
- Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. (wikipedia.org)
- In 1957, Ingram showed that hemoglobin Hb S differed from normal hemoglobin (Hb A) by a single amino acid substitution. (medscape.com)
- In sickle cell anemia, the amino acid substitution valine for glutamate occurs on the beta chain at the sixth position. (medscape.com)
- The mature form of the zymogen, human plasminogen (HPlg), contains 791 amino acids present in a single polypeptide chain. (embl.de)
- The resulting HPlm contains a heavy chain of 561 amino acid residues, originating from the N-terminus of HPlg, doubly disulfide-linked to a light chain of 230 amino acid residues. (embl.de)
- The heavy chain of HPlm consists of five repeating triple-disulfide-linked peptide regions, c. 80 amino acid residues in length, termed kringles (K), that are responsible for interactions of HPlg and HPlm with substrates, inhibitors and regulators of HPlg activation. (embl.de)
- The amino acid residues important in these kringle/ligand binding interactions have been proposed by structural determinations, and their relative importance quantified by site-directed mutagenesis experimentation. (embl.de)
- The major constituent of a senile plaque is β-amyloid (Αβ), which is a 40-43 amino acid peptide produced by the action of secretory pathway-associated proteases, namely β and γ secretases, at the C terminus of a type I membrane-spanning glycoprotein termed amyloid precursor protein (APP). (jneurosci.org)
- Interestingly, mitochondrial translocation of APP was incomplete because of an internal acidic domain present between 220 and 290 amino acids. (jneurosci.org)
Fibrinolysis1
- When there is uncertainty as to whether the cause of bleeding is primary fibrinolysis or disseminated intravascular coagulation (DIC), this distinction must be made before administering aminocaproic acid. (globalrph.com)
Doctor and pharmacist1
- tell your doctor and pharmacist if you are allergic to aminocaproic acid or any other medications. (epnet.com)
Injection11
- What do I need to tell my doctor BEFORE I take Aminocaproic Acid Injection Solution? (drugs.com)
- This is not a list of all drugs or health problems that interact with aminocaproic acid injection solution. (drugs.com)
- You must check to make sure that it is safe for you to take aminocaproic acid injection solution with all of your drugs and health problems. (drugs.com)
- What are some things I need to know or do while I take Aminocaproic Acid Injection Solution? (drugs.com)
- Tell all of your health care providers that you take aminocaproic acid injection solution. (drugs.com)
- How is this medicine (Aminocaproic Acid Injection Solution) best taken? (drugs.com)
- Use aminocaproic acid injection solution as ordered by your doctor. (drugs.com)
- Very bad muscle problems have happened with aminocaproic acid injection solution. (drugs.com)
- What are some other side effects of Aminocaproic Acid Injection Solution? (drugs.com)
- American Regent announces the launch of Selenious Acid Injection, USP in 12 mcg/2 mL single-dose vial. (americanregent.com)
- American Regent, Inc. is pleased to announce the launch of Selenious Acid Injection, USP in a new concentration and vial size. (americanregent.com)
CAPROIC ACID1
- A short-chain fatty acid anion that is the conjugate base of hexanoic acid (also known as caproic acid). (mcw.edu)
Coagulation2
- In clinical practice, aminocaproic acid is frequently used off-label for control of bleeding in patients with severe thrombocytopenia, control of oral bleeding in patients with congenital and acquired coagulation disorders, control of perioperative bleeding associated with cardiac surgery, prevention of excessive bleeding in patients on anticoagulation therapy undergoing invasive dental procedures, and reduction of the risk of catastrophic hemorrhage in patients with acute promyelocytic leukemia. (wikipedia.org)
- Aminocaproic acid is used in the treatment of Fibrinolytic Bleeding and belongs to the drug class miscellaneous coagulation modifiers . (drugs.com)
Urine2
- Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid. (globalrph.com)
- Aminocaproic acid is also used to control bleeding in the urinary tract (the organs in the body that produce and excrete urine) that may occur after prostate or kidney surgery or in people who have certain types of cancer. (epnet.com)
Interactions2
- It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing Aminocaproic Acid and Weed. (worldsbest.rehab)
- There will always be an interaction between Aminocaproic Acid and Weed in the brain 1 1.J. D. Brown and A. G. Winterstein, Potential Adverse Drug Events and Drug-Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use - PMC, PubMed Central (PMC). (worldsbest.rehab)
Drugs4
- It can increase the anxiety and depression a person experiences, and it can interact with certain other drugs including Aminocaproic Acid. (worldsbest.rehab)
- It alters the brain's functions and structure, and all pharmaceuticals and drugs including Aminocaproic Acid are designed to have an impact on the brain. (worldsbest.rehab)
- To say then that two drugs, Aminocaproic Acid and Weed, dol not interact is wrong. (worldsbest.rehab)
- The screen flagged two drugs for their ability to inhibit RPE atrophy and drusen formation: A protease inhibitor called aminocaproic acid, which likely directly blocks the complement pathway outside cells and a second agent (L745), which stops complement induced inflammation inside the cell indirectly via inactivation of the dopamine pathway. (nih.gov)
Tablets1
- Aminocaproic Acid Tablets will be available in 500mg and 1000mg strengths. (empr.com)
Doctors1
- Doctors are likely to refuse a patient a Aminocaproic Acid prescription if the individual is a weed smoker or user. (worldsbest.rehab)
Medications2
- This happens with all medications whether weed or Aminocaproic Acid is mixed with them. (worldsbest.rehab)
- Aminocaproic acid is in a class of medications called hemostatics. (epnet.com)
Treatment1
- Aminocaproic acid should not be used to treat bleeding that is not caused by faster than normal clot breakdown, so your doctor may order tests to find the cause of your bleeding before you begin your treatment. (epnet.com)
Blood2
- Correspondingly, the volume of distribution after intravenous administration has been reported to be 30.0 ± 8.2 L. After prolonged administration, aminocaproic acid has been found to distribute throughout extravascular and intravascular compartments of the body, penetrating human red blood cells as well as other tissue cells. (globalrph.com)
- Aminocaproic acid is used to control bleeding that occurs when blood clots are broken down too quickly. (epnet.com)
Cause side effects1
- Aminocaproic acid may cause side effects. (epnet.com)
Dose1
- Your doctor may start you on a high dose of aminocaproic acid and gradually decrease your dose as the bleeding is controlled. (epnet.com)
Solution1
- Aminocaproic acid comes as a tablet and a solution (liquid) to take by mouth. (epnet.com)
Side effects3
- Anyone mixing Aminocaproic Acid and weed is likely to experience side effects. (worldsbest.rehab)
- Side effects can be harmful when mixing Aminocaproic Acid and weed. (worldsbest.rehab)
- One of the milder side effects of mixing Aminocaproic Acid and Weed is Scromiting . (worldsbest.rehab)
Present1
- The crystal structure determination showed that the 6-aminohexanoic acid is present as a salt, at least in the solid state. (wikipedia.org)
Substances1
- Aminocaproic acid 500 mg is not a controlled substance under the Controlled Substances Act (CSA). (drugs.com)
Users1
- Research has found that anxiety is one of the leading symptoms created by marijuana in users, and that there is a correlation between Aminocaproic Acid and Weed and an increase in anxiety. (worldsbest.rehab)
Research1
- Of course, this could be due to the lack of studies and research completed on the mixing of Aminocaproic Acid and Weed. (worldsbest.rehab)
Case2
- There is a misplaced belief that pharmaceuticals and medication work by treating only the parts of the body affected yet this is obviously not the case in terms of Aminocaproic Acid. (worldsbest.rehab)
- The antidote for tPA in case of toxicity is aminocaproic acid . (wikidoc.org)
Medical1
- The medical term for Scromiting by mixing Aminocaproic Acid and Weed is cannabinoid hyperemesis syndrome , or CHS. (worldsbest.rehab)
Hours2
- The terminal elimination half-life for aminocaproic acid is approximately 2 hours. (globalrph.com)
- When aminocaproic acid is used to treat ongoing bleeding, it is usually taken every 3 to 6 hours. (epnet.com)