The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin. (1/206)

Comparative studies have been made on the effects of diazoacetyl-DL-norleucine methyl ester (DAN), 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) and pepstatin on acid proteases, including those from Acrocylindrium sp., Aspergillus niger, Aspergillus saitoi, Mucor pusillus, Paecilomyces varioti, Rhizopus chinensis, and Trametes sanguinea, and also porcine pepsin [EC 3.4.23.1] and calf rennin [EC 3.4.23.4] for comparative purposes. These enzymes were rapidly inactivated at similar rates and in 1:1 stiochiometry by reaction with DAN in the presence of cupric ions. The pH profiles of inactivation of these enzymes were similar and had optima at pH 5.5 to 6. They were also inactivated at similar rates by reaction with EPNP, with concomitant incorporation of nearly 2 EPNP molecules per molecule of enzyme. The pH profiles of inactivation were again similar and maximal inactivation was observed at around pH 3 to 4. Some of the EPNP-inactivated enzymes were treated with DAN and shown still to retain reactivity toward DAN. All these enzymes were inhibited strongly by pepstatin, and the reactions of DAN and EPNP with them were also markedly inhibited by prior treatment with pepstatin. These results indicate that the active sites of these enzymes are quite similar and that they presumably have at least two essential carboxyl groups at the active site in common, one reactive with DAN in the presence of cupric ions and the other reactive with EPNP, as has already been demonstrated for porcine pepsin and calf rennin. Pepstatin appears to bind at least part of the active site of each enzyme in a simmilar manner.  (+info)

Biochemical and functional profile of a newly developed potent and isozyme-selective arginase inhibitor. (2/206)

An increase in arginase activity has been associated with the pathophysiology of a number of conditions, including an impairment in nonadrenergic and noncholinergic (NANC) nerve-mediated relaxation of the gastrointestinal smooth muscle. An arginase inhibitor may rectify this condition. We compared the effects of a newly designed arginase inhibitor, 2(S)-amino-6-boronohexanoic acid (ABH), with the currently available N(omega)-hydroxy-L-arginine (L-HO-Arg), on the NANC nerve-mediated internal anal sphincter (IAS) smooth-muscle relaxation and the arginase activity in the IAS and other tissues. Arginase caused an attenuation of the IAS smooth-muscle relaxations by NANC nerve stimulation that was restored by the arginase inhibitors. L-HO-Arg but not ABH caused dose-dependent and complete reversal of N(omega)-nitro-L-arginine-suppressed IAS relaxation that was similar to that seen with L-arginine. Both ABH and L-HO-Arg caused an augmentation of NANC nerve-mediated relaxation of the IAS. In the IAS, ABH was found to be approximately 250 times more potent than L-HO-Arg in inhibiting the arginase activity. L-HO-Arg was found to be 10 to 18 times more potent in inhibiting the arginase activity in the liver than in nonhepatic tissues. We conclude that arginase plays a significant role in the regulation of nitric oxide synthase-mediated NANC relaxation in the IAS. The advent of new and selective arginase inhibitors may play a significant role in the discrimination of arginase isozymes and have important pathophysiological and therapeutic implications in gastrointestinal motility disorders.  (+info)

Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. (3/206)

A dopaminergic system in the zona incerta stimulates LH release and may mediate the positive feedback effects of the gonadal steroids on LH release. In this study the mechanisms by which steroids might increase dopamine activity in the zona incerta were investigated. In addition, experiments were conducted to determine whether the inhibitory effects of gamma-aminobutyric acid (GABA) on LH release in the zona incerta are due to suppression of dopamine activity in this area or conversely whether the stimulatory effects of dopamine on LH release are due to suppression of a tonic inhibitory GABAergic system. Ovariectomized rats were treated s.c. with oil, 5 micrograms oestradiol benzoate or 5 micrograms oestradiol benzoate followed 48 h later by 0.5 mg progesterone, and killed 54 h after the oestradiol benzoate injection. At this time the LH concentrations were suppressed in the oestradiol benzoate group and increased in the group treated with oestradiol benzoate and progesterone. The ratio of tyrosine hydroxylase:beta-actin mRNA in the zona incerta was significantly increased by the oestradiol benzoate treatment, but the addition of progesterone resulted in values similar to those in the control group. At the same time, the progesterone treatment increased tyrosine hydroxylase activity in the zona incerta as indicated by an increase in L-dihydroxyphenylalanine (L-DOPA) accumulation after 100 mg 3-hydroxybenzylhydrazine hydrochloric acid (NSD1015) kg-1 and an increase in dopamine release as indicated by a increase in dihydroxyphenylacetic acid (DOPAC) concentrations (one of the major metabolites of dopamine). Ovariectomized rats treated with oestradiol benzoate plus progesterone were also injected i.p. with 75 mg gamma-acetylenic GABA kg-1 (a GABA transaminase inhibitor) to increase GABA concentrations in the brain. This treatment had no effect on the ratio of tyrosine hydroxylase:beta-actin mRNA but decreased L-DOPA accumulation and DOPAC concentrations in the zona incerta, indicating a post-translational inhibition of dopamine synthesis and release. Treatment of ovariectomized rats with oestradiol benzoate followed by 100 mg L-DOPA i.p. to increase dopamine concentrations in the whole brain had no effect on glutamic acid decarboxylase mRNA expression in the zona incerta, although it increased the glutamic acid decarboxylase:beta-actin mRNA ratio in other hypothalamic areas (that is, the medical preoptic area, ventromedial nucleus and arcuate nucleus). In conclusion, the steroids act to increase dopamine activity in different ways: oestrogen increases tyrosine hydroxylase mRNA expression and progesterone acts after translation to increase tyrosine hydroxylase activity and dopamine release (as indicated by increases in DOPAC concentrations). This latter effect may be due to progesterone removing a tonic GABAergic inhibition from the dopaminergic system.  (+info)

Studies on convulsants in the isolated frog spinal cord. I. Antagonism of amino acid responses. (4/206)

1. The isolated frog spinal cord was used to study the effects of picrotoxin, bicuculline, and strychnine on the responses of primary afferents to amino acids. Recording was by sucrose gap technique. 2. A series of neutral amino acids was found to depolarize primary afferents. Optimal activity was obtained by an amino acid whose carboxyl and amino groups were separated by a three-carbon chain length (i.e. GABA). Amino acids with shorter (i.e. beta-alanine, glycine) or longer (i.e. delta-aminovaleric acid, epsilon-aminocaproic acid) distances between the charged groups were less potent. Imidazoleacetic acid was the most potent depolarizing agent tested. 3. Picrotoxin and bicuculline antagonized the primary afferent depolarizations of a number of amino acids tested with equal specificity. Depolarizing responses to standard (10- minus 3 M) concentrations of beta-alanine and taurine were completely blocked by these convulsants, while depolarizations to 10- minus 3 gamma-aminobutyric acid (GABA) were only partially antagonized. Glycine responses were unaffected by these agentsk; Strychnine completely blocked beta-alanine and taurine depolarizations and incompletely antagonized several other neutral amino acids. GABA, glutamate, and glycine depolarizations were not affected. 5. These results suggest that there are at least three distinct populations of neutral amino acid receptors on primary afferent terminals: a GABA-like receptor, a taurine/beta-alanine receptor, and a glycine-like receptor. The strychnine resistance of the glycine responses indictaes that the primary afferent receptors for glycine differ from those on the somata of spinal neurones.  (+info)

Inhibition of the development of the cellular slime mould Dictyostelium discoideum by omega-aminocarboxylic acids. (5/206)

Four omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concentrations of 40 mM, 75 mM, 10 mM and 5 mM, respectively, they allowed aggregation but prevented all further development at 24 degrees C. At lower concentrations, EACA allowed fruiting body formation but with a reduced number of spores per fruiting body. Only t-AMCHA had a significant inhibitory effect on the growth of myxamoebae. EACA affected development only if it was present between 8 and 16 h after the cells were deposited on the filters. Its effect was enhanced by high salt concentrations and by higher temperature, and was also dependent on the manner in which the cells were grown. Only strains capable of axenic growth displayed this sensitivity to EACA, although strains carrying only one of the genetic markers for axenic growth (axe A) were partially sensitive.  (+info)

The effect of epsilon-aminocaproic acid on biochemical changes in the development of the cellular slime mould Dictyostelium discoideum. (6/206)

epsilon-Aminocaproic acid (EACA) inhibited the development of Dictyostelium discoideum strain AX2 after the aggregation stage. Biochemical changes that occurred early in development (loss of cellular protein, RNA and carbohydrate; increase in the specific activity of N-acetylglucosaminidase, alpha-mannosidase, threonine deaminase and leucine aminopeptidase) were not affected by concentrations of EACA which blocked development; but biochemical changes that occurred later (synthesis of carbohydrate, increase in the specific activity of UDP-glucose pyrophosphorylase) were inhibited. Spores from fruiting bodies formed in the presence of low concentrations of EACA were larger, more spherical and less able to survive heat treatment than spores from fruiting bodies of control (no EACA) cells.  (+info)

Inhibition of intravascular fibrin deposition by dipyridamole in experimental animals. (7/206)

Intravascular fibrin deposition was induced in rabbits by endotoxin, the infusion of fibrin monomer (FM), and by the infusion of thrombin and EACA. A previously developed radioisotope technique was used to measure the fibrin deposits in various organs. Dipyridamole treatment of rabbits caused significant inhibition of fibrin deposition in all three experimental models. The drug also inhibited platelet consumption and, in the thrombin- and EACA-infused animals, fibrinogen consumption as well. The results obtained with dipyridamole were compared with the effect of thorotrast. It was concluded from this comparison that the effect of dipyridamole could not be attributed to inhibition of the reticuloendothelial system. It is postulated that dipyridamole inhibits the final step at which soluble FM is precipitated as fibrin in vivo.  (+info)

Solubilization of Escherichia coli nitrate reductase by a membrane-bound protease. (8/206)

Nitrate reductase extracted from the membrane of Escherichia coli by alkaline heat treatment was purified to homogeneity and used to prepare specific antibody. Nitrate reductase, precipitated by this antibody from Triton extracts of the membrane, contained a third subunit not present in the purified enzyme used to prepare the antibody. Nitrate reductase precipitated by antibody from alkaline heat extracts was composed of peptide fragments of various sizes. These fragments were produced by a membrane-bound protease which was activated by alkaline pH and heat. It is the action of this protease that releases the enzyme from the membrane, as shown by the observations that protease inhibitors decreased the amount of solubilization of the enzyme, and the enzyme remaining in the membrane after heating showed much less proteolytic cleavage than that which was released.  (+info)

Medium chain carboxylic acids, such as caproic acid, are conventionally produced from food materials. Caproic acid can be produced through fermentation by the reverse β-oxidation of lactic acid, generated from low value lignocellulosic biomass. In situ extraction of caproic acid can be achieved by membrane electrolysis coupled to the fermentation process, allowing recovery by phase separation. Grass was fermented to lactic acid in a leach-bed-type reactor, which was then further converted to caproic acid in a secondary fermenter. The lactic acid concentration was 9.36 ± 0.95 g L−1 over a 33-day semi-continuous operation, and converted to caproic acid at pH 5.5-6.2, with a concentration of 4.09 ± 0.54 g L−1 during stable production. The caproic acid product stream was extracted in its anionic form, concentrated and converted to caproic acid by membrane electrolysis, resulting in a |70 wt% purity solution. In a parallel test exploring the upper limits of production rate through cell retention, we
The IUPHAR/BPS Guide to Pharmacology. 2(S)-amino-6-boronohexanoic acid ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID | C6H13BNO5- | CID 657085 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Hpp-Aca-SDKP: a biologically active analog of Ac-SDKP; Hpp - 3-(p-hydroxyphenyl)propionic acid; Aca-OH - N-t-butyloxycarbonyl-6-amino caproic acid; SDKP - N-acetyl-N-Ser-Asp-Lys-Pro; structure in first source
Disclosed is an artificial membrane comprising a product made by cross-linking molecules of interpenetrating denatured collagen coupled at their lysine epsilon amino groups with a coupler through carbonyl groups, sulfonyl groups, or combination thereof on the coupler wherein non-coupled lysine epsilon amino groups are bonded to a modifier wherein the modifier is a carbonyl sulfonyl, carbamoyl, or β-malic acid group.
Management of a postbiopsy arterial pseudoaneurysm in a transplanted kidney: utilization of epsilon aminocaproic acid and controlled hypotension.
Looking for Aminocaproic acid? Find out information about Aminocaproic acid. 1. any substance that dissociates in water to yield a sour corrosive solution containing hydrogen ions, having a pH of less than 7, and turning litmus red... Explanation of Aminocaproic acid
Aminocaproic acid is an anti-fibrinolytic agent (an agent that prevents the breakdown of fibrin, a protein needed for proper blood clotting). R.M. Clemmons, Associate Professor of Neurology and Neurosurgery at the University of Florida Veterinary College advocates its use in the treatment of degenerative myelopathy (DM), a condition in which nerve tissue breaks down, in German Shepherds. While aminocaproic acid has been shown to provide very little benefit in the treatment of spinal cord trauma, Dr. Clemmons believes it can contribute significantly to a favorable outcome in up to eighty percent of cases of German Shepherd degenerative myelopathy (GSDM), especially when used with other supplements and diets. Details on the protocol can be found at http://neuro.vetmed.ufl.edu/neuro/DM_Web/DMofGS.htm.. Aminocaproic acid is used to intervene at a critical stage in the development of GSDM. Dr. Clemmons believes that the spinal cord is indirectly attacked by the immune system in degenerative ...
Aminocaproic acid is an anti-fibrinolytic agent (an agent that prevents the breakdown of fibrin, a protein needed for proper blood clotting). R.M. Clemmons, Associate Professor of Neurology and Neurosurgery at the University of Florida Veterinary College advocates its use in the treatment of degenerative myelopathy (DM), a condition in which nerve tissue breaks down, in German Shepherds. While aminocaproic acid has been shown to provide very little benefit in the treatment of spinal cord trauma, Dr. Clemmons believes it can contribute significantly to a favorable outcome in up to eighty percent of cases of German Shepherd degenerative myelopathy (GSDM), especially when used with other supplements and diets. Details on the protocol can be found at http://neuro.vetmed.ufl.edu/neuro/DM_Web/DMofGS.htm.. Aminocaproic acid is used to intervene at a critical stage in the development of GSDM. Dr. Clemmons believes that the spinal cord is indirectly attacked by the immune system in degenerative ...
Introduction: This retrospective case control study aims to evaluate the efficacy of the antifibrinolyticaminocaproic acid in patients undergoing bilateral simultaneous Total Hip Arthroplasty (THA). Materials and Methods: A total of 148 hips (74 patients) underwent simultaneous bilateral total hip arthroplastieswith 29 receiving Acetylsalicylic Acid (ASA) only and 45 receiving Aminocaproic Acid (ACA) withASA depending on when the surgery was performed at our institution. Results: Demographics were similar between groups as measured by average Body Mass Index (BMI), age, and gender, and there was no significant difference in length of stay or duration of operation between the two groups. Patients given aminocaproic acid had a significantly decreased change in hemoglobin on post-operative day one ( ...
Generic AMINOCAPROIC ACID availability. Has a generic version of AMINOCAPROIC ACID been approved? Find suppliers, manufacturers, and packagers
Unfortunately, retired racing greyhounds are among the large breeds that are most likely to get osteosarcoma, a type of bone cancer. Finding a cure is part of our mission, and while we work to find that cure we are offering our members free carboplatin* and epsilon aminocaproic acid (i.e., "Amicar™"). See the Programs page for details.. *Carboplatin is the best drug for the treatment of osteosarcoma in Greyhounds. Some vets like to use an alternating protocol of carboplatin and doxorubicin, but that is actually less effective in Greyhounds. Epsilon aminocaproic acid (EACA) is the generic form of Amicar™ that is recommended for use for 5 days starting with any surgical procedure to prevent the post-operative bleeding that is common in Greyhounds.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Liliana M Marín, M Cristina Iazbik, Sara Zaldivar-Lopez, Linda K Lord, Nicole Stingle, Paulo Vilar, Ana Lara-Garcia, Francisco Alvarez, Kenji Hosoya, Laura Nelson, Antonio Pozzi, Edward Cooper, Mary A McLoughlin, Rebecca Ball, William C Kisseberth, Cheryl A London, Robert Dudley, Jonathan Dyce, Melanie McMahon, Phillip Lerche, Richard Bednarski, C Guillermo Couto].
Structure, properties, spectra, suppliers and links for: Aminocaproic acid, 60-32-2, e-Aminocaproic Acid, epsilon-Aminocaproic acid, H-EAhx-OH.
Aminocaproic acid injection is an antifibrinolytic agent. It is used to treat serious bleeding conditions, especially when the bleeding occurs after dental surgery or other kinds of surgery. This medicine is also sometimes given before an operation to prevent serious bleeding for patients with medical problems that increase the chance of bleeding.
Skeletal muscle weakness with necrosis of muscle fibers has been reported following prolonged administration. The possibility of cardiac muscle damage should be considered when skeletal myopathy occurs. One case of cardiac and hepatic lesions observed in man has been reported. The patient received 2 g of aminocaproic acid every 6 hours for a total dose of 26 g. Death was due to continued cerebrovascular hemorrhage.. ...
Learn about Amicar (Aminocaproic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Creative Peptides offers ε- Aminocaproic acid for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
Amicar (aminocaproic acid) is one of the few oral medicines that you can take to prevent unnecessary bleeding if youre undergoing surgery and at high risk for bleeds. The pill or liquid formulation wont work quickly enough to stop any episodes of heavy bleeding.
Do not take this medicine during pregnancy. Do not use this medicine for kidney or bladder bleeding unless directed by your doctor. Aminocaproic acid (Amicar) should be used with caution in patients with heart, kidney, or liver disease.. You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your childs care.. Always make sure you have enough medicine on hand. Each time you refill your prescription, check to see how many refills are left. If no refills are left the pharmacy will need 2 or 3 days to contact the clinic to renew the prescription.. Check the label and expiration date before giving each dose. Ask your pharmacist what to do with outdated or unused medicines. If there is no "take-back" program empty them into the trash.. Store all medicines in their original container and away from direct sunlight or heat. Do not store in humid places such as the bathroom. Keep them out of childrens reach, locked up if ...
... : This product is a prescription drug. If your State License number is on file
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
0178] The method incorporates microorganisms capable of producing one of the following C6-difunctional alkanes of interest, particularly, adipic acid, amino caproic acid, hexamethylenediamine (HMD), or 6-hydroxyhexanoate. Other difunctional alkanes of interest include 5-aminopentanol, 5-aminopentanoate, 1,5-pentanediol, glutarate, 5-hydroxypentanoate, cadaverine, etc. Several chemical synthesis routes have been described, for example, for adipic acid and its intermediates such as muconic acid and adipate semialdehyde; for caprolactam, and its intermediates such as 6-amino caproic acid; for hexane 1,6 diamine or hexanemethylenediamine; but only a few biological routes have been disclosed for some of these organic chemicals. Therefore, aspects of the invention provide engineered metabolic routes, methods to produce difunctional alkanes from sustainable feedstock, and materials associated therewith, including isolated nucleic acids or engineered nucleic acids, polypeptides or engineered ...
Caproic acid is a compound containing six atoms of carbon, 12 atoms of hydrogen and two atoms of oxygen. It is more commonly known as hexanoic acid and is represented by the chemical formula...
AMICAR Injection contains benzyl alcohol as a preservative. The administration of medications containing benzyl alcohol as a preservative to premature neonates has been associated with a fatal "gasping syndrome." (See PRECAUTIONS, Pediatric Use).. In patients with upper urinary tract bleeding, AMICAR administration has been known to cause intrarenal obstruction in the form of glomerular capillary thrombosis or clots in the renal pelvis and ureters. For this reason, AMICAR should not be used in hematuria of upper urinary tract origin, unless the possible benefits outweigh the risk.. Subendocardial hemorrhages have been observed in dogs given intravenous infusions of 0.2 times the maximum human therapeutic dose of AMICAR and in monkeys given 8 times the maximum human therapeutic dose of AMICAR.. Fatty degeneration of the myocardium has been reported in dogs given intravenous doses of AMICAR at 0.8 to 3.3 times the maximum human therapeutic dose and in monkeys given intravenous doses of AMICAR at 6 ...
Forty-four episodes of sicklemic hematuria occurring in 40 patients during a 12-year period were reviewed. Seven of seven patients had evidence of a hyperactive fibrinolytic system. Fifteen of 38 pyelograms demonstrated obstruction of some portion of
Intern 100 mg/kg la fiecare 4 ore. Doza pentru 24 ore este de 10-15 g. In hemoragiile acute se recomanda administrarea i.v. pana la 4-5 g prima ora (diluat in 250 ml solutie salina isotona, apoi cate 1 g (in 50 ml) fiecare ora. Perfuzia se prelungeste pana la oprirea hemoragiei insa nu mai mult de 8 ore. In hipofibrinogenemia acuta pana la 100 ml solutie perfuzabila i.v. La necesitate doza poate fi repetata peste 4 ore. Granulele se dizolva in apa proaspat fiarta pana la semnul 100 ml. Solutia obtinuta contine 0,2 g acid aminocaproic in 1 ml. Copii sub 1 an 2,5 ml, 2-6 ani 2,5-5 ml, 7-10 ani 5-7 ml de 3 ori pe zi. In hemoragiile acute, copii sub 1 an 5 ml, 2-4 ani 5-7,5 ml, 5-8 ani 7,5-10 ml, 9-10 ani 15 ml de 3 ori pe zi. Cura de tratament constituie 3-14 zile.. ...
6:0 hexanoic, caproic fatty acid is a nutrient present in many other foods. The below table lists foods high in 6:0 hexanoic, caproic fatty acid other than Egg substitute, powder. ...
How much of 6:0 hexanoic, caproic fatty acid is present in Bologna, chicken, pork, beef in details, quantity how high or low 6:0 hexanoic, caproic fatty acid nutrient content it has.
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
BioVendor - BioVendor Research and Diagnostic Products is a developer and manufacturer of immunoassays, recombinant proteins, antibodies and endotoxin-removal products.
We develop new bioproduction systems with high yield and productivity for (1) chemicals and fuels such as 1,3-propanediol, caproic acid, n-butanol and biogas; (2) fine chemicals and pharmaceuticals such as amino acids, microbial lipids and recombinant proteins. Waste materials and C1 (e.g. CO2) carbons are more and more in focus as substrates. We collaborate with industrial partners in different ways, such as contract research and development, consulting and feasibility study. ...
Kim BC,Jeon BS,Kim SI,Kim H,Um Y,Sang BI (2015). Caproiciproducens galactitolivorans gen. nov. sp. nov., a bacterium capable of producing caproic acid from galactitol, isolated from a wastewater treatment plant. Int. J. Syst. Evol. Microbiol., . ...
Vigabatrin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more.
So, we now have to make a decision between two drugs. One drug is the ACTH steroid. ACTH is FDA approved (and covered by insurance), begins in the hospital, is an injection that must be given twice a day for 6 weeks, has serious, life threatening side effects (including decreased immune system) and has a 50% chance of working. Once treatment begins, well know within 2 weeks if it is working, and if it stops her seizures, she is done with the drug in 6 weeks and may never need it again, unless she has a relapse. The side effects are reversible. The other drug is called Vigabatrin (Sabril) which is not FDA approved and must be obtained in either Canada or Mexico. Vigabatrin comes in pill form, and does not have the severe side effects associated with ACTH (including the fact that it will not alter her immune system, and she does not need hospitalization.) Vigabatrin has been in use everywhere except the US for 10 years, and has not been approved by the FDA because there is a report that some ...
TY - JOUR. T1 - Aminocaproic Acid Decreases Secondary Hemorrhage After Traumatic Hyphema. AU - Mcgetrick, John J.. AU - Jampol, Lee M.. AU - Goldberg, Morton F.. AU - Frenkel, Marcel. AU - Fiscella, Richard G.. PY - 1983/7. Y1 - 1983/7. N2 - Forty-eight patients (49 eyes) had nonperforating traumatic hyphema. Twenty-eight patients (28 eyes with hyphema) received oral aminocaproic acid, an antifibrinolytic agent, in a dosage of 100 mg/kg every four hours for five days, up to a maximum daily dose of 30 g. Twenty patients (21 eyes with hyphema) received placebo in an identical regimen. One eye treated with aminocaproic acid rebled; seven eyes receiving the placebo rebled. The results of this study show a statistically significant reduction in the incidence of secondary hemorrhage in the patients receiving aminocaproic acid.. AB - Forty-eight patients (49 eyes) had nonperforating traumatic hyphema. Twenty-eight patients (28 eyes with hyphema) received oral aminocaproic acid, an antifibrinolytic ...
Author: Zhang Yan-ping, Trissel Lawrence A, Year: 1997, Abstract: The purpose of this study was to determine the stability of aminocaproic acid 10 and 100 mg/mL admixed in 5% dextrose injection and 0.9% sodium chloride injection in polyvinyl chloride bags over periods up to seven days at 4° and 23°C.

The aminocaproic acid 250-mg/mL injection was filtered and admixed in filtered 5% dextrose injection and 0.9% sodium chloride injection to yield nominal aminocaproic acid concentrations of 10 and 100 mg/mL. Evaluations were performed initially and af

Maitreyee Mukherjee, MD1, Chandan Biswas, MD2, Sajib Chatterjee, MS3, Bijoy Kumar Bandyopadhyay, MD4. 1Assistant Professor; 2Senior Resident. Department of Anesthesiology & Critical Care, R. G. Kar Medical College & Hospital, 1, Kshudiram Bose Sarani, Kolkata, West Bengal 700004, (India). 3Department of General Surgery, Nil Ratan Sircar Medical College and Hospital (NRSMCH), 138, Acharya Jagadish Chandra Bose Rd, Sealdah, Raja Bazar, Kolkata, West Bengal 700014, (India). Correspondence: Dr. Maitreyee Mukherjee, Department of Anesthesiology & Critical Care, R. G. Kar Medical College & Hospital, 1, Kshudiram Bose Sarani, Kolkata, West Bengal 700004, (India); Mobile: 09830415924; E-mail: [email protected] ABSTRACT. Background: Femoral surgeries are always associated with excessive bleeding either in the intra-operative or postoperative period; often requiring blood transfusion. Induced hypotension and antifibrinolytics have been used to decrease blood loss. Agents used in this indication ...
55132PRTHOMO SAPIENSVARIANT24Xaa = 6-aminohexanoic acid 1Gly Asp Trp Ile Asp Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser1 5 10 15Leu Leu Val Asp Lys Lys Cys Xaa Arg Arg Arg Arg Arg Arg Arg Arg20 25 30225PRTHOMO SAPIENSVARIANT17Xaa = 6-aminohexanoic acid 2Ser Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp Gly1 5 10 15Xaa Arg Arg Arg Arg Arg Arg Arg Arg20 25324PRTHOMO SAPIENSVARIANT16Xaa = 6-aminohexanoic acid 3Ile Leu Ala Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp Gly Xaa1 5 10 15Arg Arg Arg Arg Arg Arg Arg Arg20423PRTHOMO SAPIENSVARIANT15Xaa = 6-aminohexanoic acid 4Leu Ala Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp Gly Xaa Arg1 5 10 15Arg Arg Arg Arg Arg Arg Arg20522PRTHOMO SAPIENSVARIANT14Xaa = 6-aminohexanoic acid 5Ala Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp Gly Xaa Arg Arg1 5 10 15Arg Arg Arg Arg Arg Arg20621PRTHOMO SAPIENSVARIANT13Xaa = 6-aminohexanoic acid 6Phe Ser Arg Ser Leu His Ser Leu Leu Val Asp Gly Xaa Arg Arg Arg1 5 10 15Arg Arg Arg Arg Arg20720PRTHOMO ...
Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery. The lysine analogues tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) are cheaper, but it is not known if they are as effective as aprotinin. Studies were identified by searching electronic databases and bibliographies of published articles. Data from head-to-head trials were pooled using a conventional (Cochrane) meta-analytic approach and a Bayesian approach which estimated the posterior probability of TXA and EACA being equivalent to aprotinin; we used as a non-inferiority boundary a 20% increase in the rates of transfusion or re-operation because of bleeding. Peri-operative blood loss was significantly greater with TXA and EACA than with aprotinin: weighted mean differences were 106 mls (95% CI 37 to 227 mls) and 185 mls (95% CI 134 to 235 mls) respectively. The pooled relative risks (RR) of receiving an allogeneic red blood cell (RBC)
Plasmin is the effector protease of the fibrinolytic system, well known for its involvement in fibrin degradation and clot removal. However, plasmin is also recognized as a potent modulator of immunological processes by directly interacting with various cell types including leukocytes (monocytes, macrophages, and dendritic cells) and cells of the vasculature (endothelial cells, smooth muscle cells) as well as soluble factors of the immune system and components of the extracellular matrix. In fact, the removal of misfolded proteins and maintenance of tissue homeostasis seem to be major physiological functions of plasmin. However, a large body of evidence also suggests that excessive plasmin generation frequently contributes to the pathophysiology of acute and chronic inflammatory processes. Hence, one question arising from the broadening effects of plasmin in physiology is whether antifibrinolytic drugs (i.e., tranexamic acid, epsilon aminocaproic acid, or aprotinin) that target plasmin either directly
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2PHO: Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
NHS-dPEG®4-biotin, product number 10200, is a constant favorite among our customers. It has been used or featured in numerous publications over the years since it was first introduced. Biotin is normally poorly soluble in water, but the amphiphilic dPEG® linker imparts excellent solubility in water or aqueous buffer and in organic solvent. The N-hydroxysuccinimidyl (NHS) moiety of NHS-dPEG®4-biotin reacts with free primary amines, such as the amines on the side chain of lysine, forming a stable amide bond. The biotin moiety is used in labeling experiments, supramolecular construction, affinity chromatography, the creation of biotinylated antibodies, and many other applications. Read More Biotinylation with NHS-dPEG®4-biotin In times past, aminocaproic acid was coupled to biotin and activated with NHS to form the widely used NHS-LC-biotin, but NHS-LC-biotin is highly problematic, as it is insoluble in water and must be dissolved in organic media prior to use. When coupled to proteins, the linker
Aminocaproic acid is a medication that blocks the breakdown of blood clots, and is used to treat postoperative bleeding, especially in sighthounds. It is given by mouth in the form of a tablet or liquid, or it can be given by injection by your veterinarian in the hospital. Side effects are uncommon but can include vomiting, diarrhea, or decreased appetite when they do occur. Do not use this medication in pets that are currently experiencing clotting in the vessels, and use with caution in pets with heart, liver, or kidney disease. If a negative reaction occurs, call your veterinary office. ...
BioAssay Systems Arginase Inhibitor Kit (IARG-100) screens for arginase inhibitors using a chromogen that forms a colored complex specifically with urea. The color (430nm) is proportional to the arginase activity. Percent inhibition is determined by comparing treated samples to an untreated control.
Abstract: The purpose of this study was to investigate dietary effects of short-chain saturated (SCSFA), long-chain saturated (LCSFA), longchain monounsaturated (LCMFA), and long-chain polyunsaturated (LCPFA) fatty acids on growth and mineral status in male weanling rats. Two experiments were used, and the length of each experiment was four weeks. Two levels (5% and 10%) of dietary fat were used in each experiment. In Experiment 1 butyric and caproic acids (SCSFA), stearic and palmitic acids (LCSFA), oleic acid (LCMFA) and liinoleic and linolenic acids (LCPFA) were used to formulate four test diets. A corn oil reference diet was also included in Experiment 1. In Experiment 2 Iinoleic, linolenic, palmitic and stearic acids were used to formulate P/S ratios of 0.1, 0.4, 1.0, 4.0 and 8.0. Parameters used for evaluating animal responses included weight gain, hemoglobin, hematocrit, liver, kidney, spleen and testes concentrations of copper, iron, zinc and manganese and bone (femur and tibia) levels ...
... is a derivative of BDP TR containing a long linker based on aminohexanoic acid (C6). The dye has absorption and emission close to ROX (Texas Red). The NHS ester function can be used for the conjugation with proteins and peptides.
Comments: 78 Pages.. Nylon comprises a family of man-made substances that were first manufactured in 1935. Nylonases are biological enzymes that can break down nylon oligomers. Although the most prominent nylonases are within the family of enzymes classified as 6-aminohexanoate hydrolases, some enzymes not formally classified as 6-aminohexanoate hydrolases also have the ability to breakdown nylons, and so can also be classified as nylonases. Organisms that encode a nylonase enzyme do not necessarily have the ability to actually survive on a nylon substrate as their sole carbon source. Among the first documented organisms that did have this ability was the soil bacterium Arthrobacter KI72. It has long been thought that nylonase genes and proteins were essentially absent from the biosphere prior to 1935. This belief led to the widespread assumption that any nylonase gene observed in the present must have emerged since 1935. Several authors developed hypothetical models of how a specific nylonase ...
van den Berg MPM, Kurhade SH, Maarsingh H, Erceg S, Hulsbeek IR, Boekema PH, Kistemaker LEM, van Faassen M, Kema IP, Elsinga PH, Dömling A, Meurs H, Gosens R. J Pharmacol Exp Ther. 2020 Jul;374(1):62-73. Publication: https://pubmed.ncbi.nlm.nih.gov/32269169/ Abstract Arginase is a potential target for asthma treatment. However, there are currently no arginase inhibitors available for clinical […]. ...
... (abbreviated as Nva) is an amino acid with the formula CH3(CH2)2CH(NH2)CO2H. The compound is an isomer of the more common amino acid valine. Like most other α-amino acids, norvaline is chiral. It is a white, water-soluble solid. Norvaline is a non-proteinogenic unbranched-chain amino acid. It has previously been reported to be a natural component of an antifungal peptide of Bacillus subtilis. Norvaline and other modified unbranched chain amino acids have received attention because they appear to be incorporated in some recombinant proteins found in E. coli. Its biosynthesis has been examined. The incorporation of Nva into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller-Urey experiments probing prebiotic synthesis of amino acids, norvaline, but also norleucine, are produced. Norvaline is known to promote tissue regeneration and muscle growth, and to become a precursor in the penicillin biosynthetic pathway. Norvaline and norleucine ...
The LD50 value of sorbic acid is estimated to be between 7.4 and 10 g/kg. Sorbic acid and sorbates therefore have a very low mammalian toxicity - hence their extensive use in food and beverage preservation. Sorbic acid occurs naturally in wild berries, is relatively unstable and rapidly degraded in soil, hence it is considered environmentally friendly. In the body it is generally metabolized by the same oxidation pathway as the 5-carbon saturated fatty acid caproic acid. There is a general consensus that sorbic acid and sorbates are intrinsically devoid of carcinogenic activity. However they have been shown to have the potential to undergo conversion to potential mutagens either through oxidation, or through a chemical reaction with nitrites at pH of 2-4.2 - the latter conditions being ones that mimic the gastric environment. In living yeast cells sorbic acid enhances oxygen free radical formation by the mitochondrial electron transport chain, leading to damage to the mitochondrial DNA. ...
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100-7. PMID 21948594. doi:10.1093/nar/gkr777. edit ...
Carcinoembryonic antigen-related cell adhesion molecule 7 is a protein that in humans is encoded by the CEACAM7 gene. ENSG00000007306 GRCh38: Ensembl release 89: ENSG00000280501, ENSG00000007306 - Ensembl, May 2017 "Human PubMed Reference:". Thompson J, Zimmermann W, Nollau P, Neumaier M, Weber-Arden J, Schrewe H, Craig I, Willcocks T (Jan 1995). "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas". J Biol Chem. 269 (52): 32924-31. PMID 7806520. Thompson J, Seitz M, Chastre E, Ditter M, Aldrian C, Gespach C, Zimmermann W (May 1997). "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis". Cancer Res. 57 (9): 1776-84. PMID 9135022. "Entrez Gene: CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7". Human CEACAM7 genome location and CEACAM7 gene details page in the UCSC Genome Browser. Douard R, Wind P, Sales JP, et al. (2006). "Long-term prognostic value of detection of ...
Two and a half years into World War I, the United States had maintained a status of neutrality while the Allied armies had been fighting those of the Central Powers in the trenches of northern France and Belgium. Although President Woodrow Wilson had been re-elected - winning the election on the slogan, "He kept us out of the war" - it became increasingly difficult to maintain that position.[3] After the Royal Navy had been engaged in a successful naval blockade against all German shipping for some time, the German Supreme High Command concluded that only a total submarine offensive would break the stranglehold. Although the decision was made on 9 January 1917, the Americans were uninformed of the operation until 31 January.[4] The Germans abrogated their Sussex pledge (not to sink merchant ships without due warning and to save human lives wherever possible) and began an unrestricted U-boat campaign on 1 February 1917. Since it was obvious that US shipping would also come under attack in the ...
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML. The DNA sequence of human chromosome 21. 405, 2000, p. 311-9. PMID: 10830953. ...
... (original trade name Amaryl) is an orally available medium-to-long-acting sulfonylurea antidiabetic drug. It is sometimes classified as either the first third-generation sulfonylurea, or as second-generation. Glimepiride is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin. Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas. Side effects from taking glimepiride include gastrointestinal tract (GI) disturbances, occasional allergic reactions, and rarely blood production disorders including thrombocytopenia, leukopenia, and hemolytic anemia. In the initial weeks of treatment, the risk of hypoglycemia may be increased. Alcohol consumption and exposure to sunlight should be restricted because they can worsen side effects. Gastrointestinal absorption is complete, with no ...
A wildland fire tender is a specialized vehicle capable of bringing water, foam, or dry chemicals to fire trucks in the field that are engaged on the fireline. These vehicles are specifically designed for fire fighting often with four-wheel drive, rugged suspension and high wheel clearance for mountainous dirt road conditions. According to the National Fire Protection Association, if the apparatus will be used primarily for outdoor and wildland responses, then it is to be considered a wildland fire apparatus and must conform to NFPA 1906. Fire tenders are generally equipped with associated fire station equipment including required number of breathing apparatus, first aid kits, telescopic ladders, heat-resisting fiberglass blankets, overall suits, electrically insulated rubber hand gloves, fireman's axes with insulated handle, fireman's helmets made of fiberglass, leather belt and pouch for axe, etc. Often the technique of pump-and-roll is used where the vehicle drives with the pump engaged while ...
... is a recurring character in the novels of American author Kurt Vonnegut. He appears throughout various novels as an alcoholic, and a philanthropist who claims to be a volunteer fireman. He runs the Rosewater Foundation, an organization created to keep the family's money in the family. He is among the few fans of the novels of Kilgore Trout (another of Vonnegut's creations). God Bless You, Mr. Rosewater, or, Pearls Before Swine, the first of Vonnegut's novels to feature the character of Eliot Rosewater, is also the one in which he is the most prominent. The novel follows much of his life as the liberal son of a rich, conservative Senator from Rosewater County, Indiana who founded the Rosewater Foundation. Eliot Rosewater is convinced that he should spend the family riches to help the poor and uses the Foundation to this end, an idea looked down upon by his father. Norman Mushari, an opportunistic former associate of the Rosewater family lawyer, attempts to have Eliot declared ...
... je kardioselektivni beta blokator sa intrinsičnom simpatomimetičkom aktivnošću. On je stoga podesniji od beta blokatora koji nisu kardioselektivni za primenu kod pacijenata sa astmom ili hroničnam opstruktivnom bolešću pluća. U dozama manjim od 800 mg dnevno njegovi konstrikcini efekti na bronhijalnom sistemu i glatkim mišićima krvnih sudova su samo 10% do 30% nivoa izazvanih propranololskim tretmanom. Postoje eksperimentalni podaci da se kardioselektivna svojstva gube pri dozama od 800 mg/dan i većim.. ...
... is a large extracellular matrix proteoglycan that is present in a variety of human tissues. It is encoded by the VCAN gene. Versican is a large chondroitin sulfate proteoglycan with an apparent molecular mass of more than 1000kDa. In 1989, Zimmermann and Ruoslahti cloned and sequenced the core protein of fibroblast chondroitin sulfate proteoglycan. They designated it versican in recognition of its versatile modular structure. Versican belongs to the lectican protein family, with aggrecan (abundant in cartilage), brevican and neurocan (nervous system proteoglycans) as other members. Versican is also known as chondroitin sulfate proteoglycan core protein 2 or chondroitin sulfate proteoglycan 2 (CSPG2), and PG-M. These proteoglycans share a homologous globular N-terminal, C-terminal, and glycosaminoglycan (GAG) binding regions. The N-terminal (G1) globular domain consists of Ig-like loop and two link modules, and has Hyaluronan (HA) binding properties. Versican occurs in 5 isoforms : V0, ...
... core protein is a protein that in humans is encoded by the NCAN gene. Neurocan is a member of the lectican / chondroitin sulfate proteoglycan protein families and consists of neurocan core protein and chondroitin sulfate. It is thought to be involved in the modulation of cell adhesion and migration. Neurocan is a significant component of the extracellular matrix, and its levels are modulated by a variety of factors, but mice in which the NCAN gene has been knocked out show no easily observable defects in brain development or behavior. However, a genome-wide association study published in 2011 identified Neurocan as a susceptibility factor for bipolar disorder. A more comprehensive study published in 2012 confirmed that association. The 2012 study examined correlations between NCAN alleles and various symptoms of bipolar disorder, and also examined the behavior of NCAN knockout mice. In the human subjects, it was found that NCAN genotype was strongly associated with manic symptoms but ...
... (c. 1660 - c. 1717) was a radical German philosopher and materialist who wrote under the nom-de-plume Realis de Vienna. A follower of Spinoza and acquaintance of Leibniz, Wagner did not believe that the universe or bible were divine creations, and sought to extricate philosophy and science from the influence of theology. Wagner also held radical political views critical of the nobility and monarchy. After failing to establish lasting careers in cities throughout German-speaking Europe, Wagner died in or shortly after 1717. Wagner studied under scholar Christian Thomasius in Leipzig, and in 1691 published a philosophical tract critical of Thomasius, "Discourse and doubts in Christ: a Thomasian introduction to courtly philosophy." The tract satirically dubbed Thomasius the "German Socrates" and attracted attention within philosophical circles, including from Leibniz, who sought to contact Wagner. In the same year, after a dispute over rent, Wagner was expelled from university and ...
Aminocaproates* * Aminocaproic Acid / pharmacology * Animals * Antifibrinolytic Agents / pharmacology* * Calcium / metabolism * ...
Cerebral Hemorrhage, Traumatic; Brain Hemorrhage, Cerebral, Traumatic; Cerebral Hematoma, Traumatic; Intracerebral Hemorrhage, Traumatic. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Battocletti, J. H., Linehan, J. H., Larson, S. J., Sances, A., Bowman, R. L., Kudravcev, V., Genthe, W. K., Halbach, R. E. & Evans, S. M., Jan 1 1972, In : IEEE Transactions on Biomedical Engineering. BME-19, 6, p. 403-407 5 p.. Research output: Contribution to journal › Letter ...
Brägelmann, J., Dammert, M. A., Dietlein, F., Heuckmann, J. M., Choidas, A., Böhm, S., Richters, A., Basu, D., Tischler, V., Lorenz, C., Habenberger, P., Fang, Z., Ortiz-Cuaran, S., Leenders, F., Eickhoff, J., Koch, U., Getlik, M., Termathe, M., Sallouh, M., Greff, Z. & 14 others, Varga, Z., Balke-Want, H., French, C. A., Peifer, M., Reinhardt, H. C., Örfi, L., Kéri, G., Ansén, S., Heukamp, L. C., Büttner, R., Rauh, D., Klebl, B. M., Thomas, R. K. & Sos, M. L., szept. 19 2017, In : Cell Reports. 20, 12, p. 2833-2845 13 p.. Research output: Article ...
TY - JOUR. T1 - Biorelevant polyanions stabilize fibrin against mechanical and proteolytic decomposition. T2 - Effects of polymer size and electric charge. AU - Komorowicz, Erzsébet. AU - Balázs, Nóra. AU - Tanka-Salamon, Anna. AU - Varga, Z.. AU - Szabó, László. AU - Bóta, A.. AU - Longstaff, Colin. AU - Kolev, K.. PY - 2020/2/1. Y1 - 2020/2/1. N2 - The release of neutrophil extracellular traps (NETs) containing DNA and histones is an essential mechanism in the neutrophil-mediated innate immunity. In thrombi the polyanionic DNA confers mechanical and lytic resistance to fibrin and heparins interfere with the effects of NET components. Heparins are polyanions used not only as therapeutic agents, but they are also released by mast cells at entry sites of pathogens. Platelets and microorganisms release a different type of polyanions (polyphosphates) of various size (in the range 60-1000 phosphate monomers). With the current study we aimed to evaluate if the stability of fibrin is influenced ...
aminocaproates. Drug Categories. amino acids, peptides, and proteins. Drug Categories. amino acids. ...
Aminocaproates. Caerulein. Ceruletide. MCM1 Protein. Minichromosome Maintenance 1 Protein. D13 - Nucleic Acids, Nucleotides, ...
Aminocaproates *Aminocaproic Acid *Mycophenolic Acid *Penicillic Acid *Caprylates *Carbamates *albendazole *Aldicarb *Benomyl * ...
Dallos, P., Billone, M. C., Durrant, J. D., Wang, C. Y. & Raynor, S., Jan 1 1972, In : Science. 177, 4046, p. 356-358 3 p.. Research output: Contribution to journal › Article ...
Aminocaproates, Estradiol, 4-Aminobutyrate Transaminase, gamma-Aminobutyric Acid, Baclofen, Muscimol, Gonadotropins, Pituitary ... Substances mentioned in the article: Aminocaproates; Gonadotropins, Pituitary; Muscimol; Testosterone; Estradiol; gamma- ... Mesh terms: 4-Aminobutyrate Transaminase/antagonists & inhibitors; Aminocaproates/pharmacology; Animals; Baclofen/pharmacology ...
Aminocaproates, pharmacology, Animals, Complement Inactivator Proteins, Erythrocytes, immunology, Hemolysis, Humans, Sheep, ...
Aminocaproates, Arginine, analogs & derivatives, chemistry, Blood Proteins, Caproates, Chromatography, High Pressure Liquid, ...
Aminocaproates , Anesthesia, Local , Cadaver , Mouth , Nose , Surgery, Oral 16. Morphometric Analysis of the Supraorbital and ...
Aminocaproates , Ear Canal , Humans , Inflammation , Mouth , Temporomandibular Joint , Tinnitus 19. The Diagnosis Criteria of ...
Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, Zimmermann DR, Lemire JM, Fischer JW, Wight TN, Clowes AW. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J Biol Chem. 2001 Apr 20; 276(16):13372-8 ...
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Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50 ...
"Aminocaproates" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Aminocaproates" by people in this website by year, and whether ... Below are the most recent publications written about "Aminocaproates" by people in Profiles. ... "Aminocaproates" was a major or minor topic of these publications. To see the data from this visualization as text, click here. ...
Aminocaproates; Antibiotics, Antineoplastic; Arginase; Bleomycin; Boron Compounds; Collagen; Hypertension, Pulmonary; Lung; ...
aminocaproates - pharmacology (1) 1 Filter by. Remove filter. analysis (1) 1 Filter by. Remove filter. anatomy (1) 1 ...
Aminocaproates Medicine & Life Sciences * Systemic Lupus Erythematosus Medicine & Life Sciences * SS-A antigen Medicine & Life ...
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  • This graph shows the total number of publications written about "Aminocaproates" by people in this website by year, and whether "Aminocaproates" was a major or minor topic of these publications. (childrensmercy.org)