Silymarin: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Milk Thistle: The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.Cell Line, Tumor: A cell line derived from cultured tumor cells.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Plasminogen Activator Inhibitor 1: A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASESMedroxyprogesterone: (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.Plasminogen Inactivators: Important modulators of the activity of plasminogen activators. The inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.Urokinase-Type Plasminogen Activator: A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Confined Spaces: A space which has limited openings for entry and exit combined with unfavorable natural ventilation such as CAVES, refrigerators, deep tunnels, pipelines, sewers, silos, tanks, vats, mines, deep trenches or pits, vaults, manholes, chimneys, etc.Occupational Diseases: Diseases caused by factors involved in one's employment.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Occupational Medicine: Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.Magnesium Silicates: A generic term for a variety of compounds that contain silicon, oxygen, and magnesium, and may contain hydrogen. Examples include TALC and some kinds of ASBESTOS.Anilino Naphthalenesulfonates: A class of organic compounds which contain an anilino (phenylamino) group linked to a salt or ester of naphthalenesulfonic acid. They are frequently used as fluorescent dyes and sulfhydryl reagents.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Benzene: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.Ethylene Oxide: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid: An inhibitor of anion conductance including band 3-mediated anion transport.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Micronucleus Tests: Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Skin Irritancy Tests: Tests or bioassays that measure the skin sensitization potential of various chemicals.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Conductometry: Determination of the quantity of a material present in a mixture by measurement of its effect on the electrical conductivity of the mixture. (Webster, 3d ed)Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Hair Preparations: Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Clothing: Fabric or other material used to cover the body.Interior Design and Furnishings: The planning of the furnishings and decorations of an architectural interior.BooksLice Infestations: Parasitic attack or subsistence on the skin by members of the order Phthiraptera, especially on humans by Pediculus humanus of the family Pediculidae. The hair of the head, eyelashes, and pubis is a frequent site of infestation. (From Dorland, 28th ed; Stedman, 26th ed)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Biosimilar Pharmaceuticals: BIOLOGIC PRODUCTS that are imitations but not exact replicas of innovator products.Therapies, Investigational: Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.Awards and PrizesDiffusion of Innovation: The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.Interinstitutional Relations: The interactions between representatives of institutions, agencies, or organizations.
Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl. (1/127)Aberrant crypt foci (ACF) are preneoplastic lesions for colon cancer. Altered amounts of copper-zinc (CuZnSOD) and manganese (MnSOD) superoxide dismutases have been implicated in multistage carcinogesis of both rodents and humans. Dietary factors are potential modulators of both CuZnSOD and MnSOD activity. The purpose of this study was to investigate the interactive effects of dietary copper, manganese, and iron on 3,2'-dimethyl-4-aminobiphenyl (DMABP)-induced ACF and superoxide dismutase activities in weanling rats fed low or adequate copper (0.8 or 5.1 microg Cu/g diet), low or adequate manganese (0.6 or 17 microg Mn/g diet), and adequate or high iron (37 or 140 microg Fe/g diet). Twelve rats were allowed free access to each of these eight diets for 3.5 wk prior to DMABP administration and for an additional 8 wk after the first DMABP injection. Rats fed low dietary copper had 105% (P < 0.0001) higher formation of DMABP-induced ACF than those fed adequate dietary copper. Rats ingesting low rather than adequate dietary manganese had 23% higher formation of ACF, and rats ingesting high rather than adequate dietary iron had 18% higher formation of ACF. Heart total superoxide dismutase activity was significantly correlated with the number of ACF (r = -0.43, P < 0.0001) in rats administered DMABP. These results suggest that dietary alterations that affect superoxide dismutase activity may affect cancer susceptibility. (+info)
Molecular and genetic damage from environmental tobacco smoke in young children. (2/127)To assess the risks of early life exposure to environmental tobacco smoke (ETS), we tested whether four biomarkers in peripheral blood were associated with home ETS exposure in Hispanic and African-American children. The biomarkers included cotinine (a metabolite of nicotine) and three indicators of molecular and genetic damage from mutagens/carcinogens, protein adducts formed by the carcinogens 4-aminobiphenyl (4-ABP) and polycyclic aromatic hydrocarbons (PAHs), and sister chromatid exchanges (SCEs). We also explored possible ethnic differences in biomarkers. The study cohort comprised 109 Hispanic and African-American preschool children (1-6 years of age). Plasma cotinine was analyzed by gas chromatography, 4-ABP-hemoglobin adducts by gas chromatography-mass spectroscopy, PAH-albumin adducts by ELISA, and SCEs by cytogenetic techniques. Data on the amount of smoking by mothers (average 10.5 cigarettes per day) and other household members and regular visitors (average 6.5 cigarettes per day) were obtained by interview-administered questionnaires. Cotinine, 4-ABP-hemoglobin adducts, and PAH-albumin were significantly higher (P < 0.05) in the ETS-exposed children compared with the unexposed. SCEs were marginally higher (P = 0.076). African-American children had higher levels of cotinine (P = 0.059) and PAH-albumin (P = 0.02) than Hispanic children, after controlling for exposure to ETS. These results indicate molecular and genetic damage in minority children with (+info)
Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC-ES-MS. (3/127)Electrospray mass spectrometry (ES-MS) is a powerful tool for analysis of carcinogen-adducted DNA. In this study, we developed a quantitative isotope dilution method for analysis of N-(deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-4-ABP), the principal nucleoside adduct derived from enzymatic hydrolysis of 4-aminobiphenyl (4-ABP)-modified DNA. The method used column switching valves to perform on-line sample concentration and cleanup, which permitted direct analysis of enzymatic DNA hydrolysates using narrow-bore liquid chromatography (LC). ES-MS detection was performed using a single quadrupole instrument by monitoring M+H+ and two fragment ions characteristic for dG-C8-4-ABP, along with M+H+ and a fragment ion for the deuterated internal standard. The detection limit for dG-C8-4-ABP in DNA hydrolysates was approximately 10 pg on-column, equivalent to 0.7 dG-C8-4-ABP adducts in 10(7) normal nucleotides for a sample containing 100 microg DNA. The method was applied to the analysis of calf thymus DNA modified in vitro through reaction with N-hydroxy-4-ABP and of hepatic DNA isolated from mice treated in vivo with two dose levels of 4-ABP. (+info)
Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. (4/127)Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N'-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-benzidine, 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and N-hydroxy-N-acetyl-4-aminobiphenyl. The (3)H- and (14)C-labeled glucuronides were prepared with human or rat liver microsomes using UDP-glucuronic acid as cosubstrate. Each of the 10 glucuronides (6-12 microM) was incubated at pH 5.5 or 7.0 with either human recombinant (pure) or E. coli (commercial preparation) beta-glucuronidase for 30 min at 37 degrees C. Hydrolysis was measured by HPLC. Reaction conditions were optimized, using the O-glucuronide of N-hydroxy-N,N'-diacetylbenzidine. Both enzymes preferentially hydrolyzed O-glucuronides over N-glucuronides and distinguished between structural isomers. With E. coli beta-glucuronidase at pH 7.0, selectivity was demonstrated by the complete hydrolysis of N-hydroxy-N-acetyl-4-aminobiphenyl O-glucuronide in the presence of N-acetylbenzidine N-glucuronide, which was not hydrolyzed. Metabolism by both enzymes was completely inhibited by the specific beta-glucuronidase inhibitor saccharic acid-1,4-lactone (0.5 mM). The concentration of human beta-glucuronidase necessary to achieve significant hydrolysis of glucuronides was substantially more than the amount of enzyme reported previously to be present in urine under either normal or pathological conditions. The bacterial enzyme may hydrolyze O-glucuronides, but not N-glucuronides, in urine at neutral pH. Thus, the nonenzymatic hydrolysis of N-glucuronides by acidic urine is likely a more important source of free amine than enzymatic hydrolysis. (+info)
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. (5/127)4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA adducts of 4-ABP are found in tobacco smokers. In vitro metabolism studies with human and rat liver microsomes have shown that CYP1A2 is primarily responsible for catalyzing N-hydroxylation, the initial step in the metabolic activation of 4-ABP. To determine whether this P450 is a rate limiting pathway for hepatocarcinogenesis, CYP1A2-null mice were analyzed at 16 months of age and were compared with wild-type mice in their response to 4-ABP using the neonatal mouse bioassay and two different doses of the carcinogen. Overall differences in incidences of hepatocellular adenoma, carcinoma and preneoplastic foci were not significant between either genotypes or 4-ABP doses used, whereas small, but significant, differences were found for specific types of foci. These results suggest that while CYP1A2 levels may not be rate limiting for 4-ABP metabolism to produce tumors and foci, it may modulate the induction process of some types of liver foci in either a positive or negative manner. In vitro studies using CYP1A2-null and wild-type mouse liver microsomes revealed that CYP1A2 is not the sole P450 required for 4-ABP N-hydroxylation and that another, yet to be identified, P450 is likely to be involved. (+info)
Mortalities of workers at the Nitro plant with exposure to 2-mercaptobenzothialzole. (6/127)OBJECTIVES: An update of a study of workers exposed to 2-mercaptobenzothiazole (MBT) at a rubber chemicals plant in Nitro, West Virginia is reported. The earlier study found high rates of lung cancer, prostate cancer, and bladder cancer in these workers who also had potential exposure to 4-aminobiphenyl (PAB), a potent bladder carcinogen. METHODS: This cohort mortality study examines the mortalities of 1059 full time white male production workers employed at the plant from 1955 to 1977. A detailed exposure assessment was done on the 600 workers with exposure to MBT. Nine years of additional follow up to the previous study are added. RESULTS: It was found that MBT workers have expected rates of lung (standardised mortality ratio (SMR) = 1.0 95% confidence interval (95% CI) 0.7 to 1.5) and prostate (SMR = 0.9, 95% CI 0.2 to 2.3) cancer. There was an excess of bladder cancer among MBT workers who had definite exposure to PAB (SMR = 27.1, 95% CI 11.7 to 53.4), and MBT workers with potential exposure to PAB (SMR = 4.3, 95% CI 1.4 to 10.0). However, there were no deaths from bladder cancer among workers with no exposure to PAB (SMR = 0.0, 95% CI 0.0 to 24.7), although there were only 0.2 deaths expected. CONCLUSIONS: The potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. However, exposure to MBT does not seem to increase the risk of most cancers including cancers of the lung and prostate. (+info)
Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism. (7/127)Mitochondrial dihydroorotate dehydrogenase (DHOdehase; EC 22.214.171.124) is a target of anti-proliferative, immunosuppressive and anti-parasitic agents. Here, redoxal, (2,2'-[3,3'-dimethoxy[1, 1'-biphenyl]-4,4'-diyl)diimino]bis-benzoic acid, was studied with isolated mitochondria and the purified recombinant human and rat enzyme to find out the mode of kinetic interaction with this target. Its pattern of enzyme inhibition was different from that of cinchoninic, isoxazol and naphthoquinone derivatives and was of a non-competitive type for the human (K(ic)=402 nM; K(iu)=506 nM) and the rat enzyme (K(ic)=116 nM; K(iu)=208 nM). The characteristic species-related inhibition of DHOdehase found with other compounds was less expressed with redoxal. In human and rat mitochondria, redoxal did not inhibit NADH-induced respiration, its effect on succinate-induced respiration was marginal. This was in contrast to the sound effect of atovaquone and dichloroallyl-lawsone, studied here for comparison. In human mitochondria, the IC(50) value for the inhibition of succinate-induced respiration by atovaquone was 6.1 microM and 27.4 microM for the DHO-induced respiration; for dichlorallyl-lawsone, the IC(50) values were 14.1 microM and 0.23 microM. (+info)
N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels. (8/127)Aminobiphenyls (ABPs) in tobacco have been implicated in bladder cancer etiology in smokers. N-Acetylation of ABPs in the liver, predominantly by the N-acetyltransferase 2 (NAT2) isozyme, represents a detoxification pathway, whereas O-acetylation of N-hydroxy-ABPs in the bladder, predominantly by the N-acetyltransferase 1 (NAT1) isozyme, represents a bioactivation pathway. We and others have demonstrated that NAT2 phenotype affects 3- and 4-ABP-hemoglobin adduct levels (higher levels in slow acetylators), which are considered valid biomarkers of the internal dose of ABP to the bladder. We have also shown that NAT1 genotype (NAT1*10 allele) is associated with increased DNA adduct levels in urothelial tissue and higher risk of bladder cancer among smokers. It is not known whether NAT1*10 genotype influences ABP-hemoglobin adduct levels. Therefore, we assessed 403 primarily non-Hispanic white residents of Los Angeles County for their NAT2 acetylator phenotype, NAT1*10 acetylator genotype, and 3- and 4-ABP-hemoglobin adduct levels. Eighty-two subjects were current tobacco smokers of varying intensities. Tobacco smokers had significantly higher mean 3- and 4-ABP-hemoglobin adduct levels relative to nonsmokers. The levels increased with increased amounts smoked per day (two-sided, P < 0.0001 in all cases). With adjustment for NAT1 genotype and race, the smoking-adjusted geometric mean level of 3-ABP-hemoglobin adducts in NAT2 slow acetylators was 47% higher than that in NAT2 rapid acetylators (P = 0.01). The comparable value for 4-ABP-hemoglobin adducts was 17% (P = 0.02). In contrast, no association between NAT1*10 genotype and 3- or 4 ABP-hemoglobin adduct levels was observed after adjustment for NAT2 phenotype, smoking, and race. The present study suggests that the impact of the NAT1*10 genotype on 3- and 4-ABP-hemoglobin adducts is noninformative on the possible association between NAT1 activity and bladder cancer risk. (+info)
4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism is catalyzed by N-hydroxylation via cytochrome P450 1A2. It is then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The urinary metabolites of 4-aminobiphenyl include 4-acetylaminobiphenyl, 4-hydroxy-4-aminobiphenyl, 2-hydroxy-4-acetylaminobiphenyl, 4-hydroxy-4-acetylaminobiphenyl, 3-hydroxy, 4-methoxy-4-acetylaminobiphenyl, 4-hydroxy, 3-methoxy-4-acetylaminobiphenyl, and 3,4-dihydroxy-4-acetylaminobiphenyl. (8, 4 ...
4-Aminobiphenyl price,buy Formaldehyde,Formaldehyde supplier-Henan Tianfu Chemical Co., Ltd.
A multistep in vitro/in vivo transformation system was used to test the transforming effect(s) of the human bladder procarcinogen 4-aminobiphenyl (ABP) and two putative proximate carcinogenic metabolites, N-hydroxy-4-aminobiphenyl (N-OH-ABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP), on a clonally derived nontumorigenic SV40-immortalized human uroepithelial cell line, SV-HUC. SV-HUC were exposed in vitro to concentrations of ABP, N-OH-ABP, or N-OH-AABP that caused a range of cytotoxicity from 5 to 76%. Tumorigenic transformation of SV-HUC, as assessed by the ability of the exposed cells to form carcinomas when inoculated s.c. into athymic nude mice, was achieved after a single exposure to ABP, N-OH-ABP, or N-OH-AABP. In the tumorigenic transformation experiments, 28 of 45 mice representing all 15 carcinogen-exposed observation groups formed carcinomas, whereas none of 9 mice from control groups formed carcinomas (P = 0.001). Neoplastic progression of a low grade regressive squamous cell ...
7'-Amino-1',3'-dimethyl-2,2',4'-trioxo-6'-spiro[1H-indole-3,5'-pyrano[2,3-d]pyrimidine]carbonitrile | C17H13N5O4 - PubChem
7-Amino-1,3-dimethyl-2,2,4-trioxo-6-spiro[1H-indole-3,5-pyrano[2,3-d]pyrimidine]carbonitrile | C17H13N5O4 | CID 3716403 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
3',5'-Dimethyl-3-(4-fluorophenyl)propiophenone - Alfa Chemistry
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
DNA Adduct Formation of 4-Aminobiphenyl and Heterocyclic Aromatic Amines in Human Hepatocytes. - ANSES
DNA adduct formation of the aromatic amine, 4-aminobiphenyl (4-ABP), a known human carcinogen present in tobacco smoke, and the heterocyclic aromatic amines (HAAs), 2-amino-9H-pyrido[2,3-b]indole (AαC), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), and 2-amino-3,8-dimethylmidazo[4,5-f]quinoxaline (MeIQx), potential human carcinogens, which are also present in tobacco smoke or formed during the high-temperature cooking of meats, was investigated in freshly cultured human hepatocytes. The carcinogens (10 μM) were incubated with hepatocytes derived from eight different donors for time periods up to 24 h. The DNA adducts were quantified by liquid chromatography-electrospray ionization mass spectrometry with a linear quadrupole ion trap mass spectrometer. The principal DNA adducts formed for all of the carcinogens were N-(deoxyguanosin-8-yl) (dG-C8) adducts. The levels of adducts ranged from 3.4 to 140 adducts per 10(7) DNA bases. The highest level of
Destruction of carcinogens in laboratory wastes. III. Destruction of 4-aminobiphenyl, 4-nitrobiphenyl, and 4,4′-methylene-bis-...
TY - JOUR. T1 - Destruction of carcinogens in laboratory wastes. III. Destruction of 4-aminobiphenyl, 4-nitrobiphenyl, and 4,4′-methylene-bis-(o-chloroaniline) by permanganate. AU - Barek, J.. AU - Berka, A.. AU - Müller, M.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - A suitable method for destruction of carcinogenic amino and nitro compounds (4-amino-biphenyl, 4-nitrobiphenyl, and 4,4′-methylene-bis(o-chloroaniline)) in laboratory wastes has been developed. The method is based on the oxidation of these substances with potassium permanganate in sulfuric acid medium resulting in a thorough destruction of the test substances.. AB - A suitable method for destruction of carcinogenic amino and nitro compounds (4-amino-biphenyl, 4-nitrobiphenyl, and 4,4′-methylene-bis(o-chloroaniline)) in laboratory wastes has been developed. The method is based on the oxidation of these substances with potassium permanganate in sulfuric acid medium resulting in a thorough destruction of the test substances.. UR - ...
Functional characterization of four allelic variants of human cytochrome P450 1A2.
Zhou H., Josephy P.D., Kim D., Guengerich F.P.. Human cytochrome P450 1A2 catalyzes important reactions in xenobiotic metabolism, including the N-hydroxylation of carcinogenic aromatic amines. In 2001, Chevalier et al. reported four new P450 1A2 sequence variants in the human population. We have now expressed these variants in Escherichia coli and measured protein expression (optical spectroscopy of holoenzyme and immunoblotting) and bioactivation of IQ (2-amino-3-methylimidazo[4,5-f]quinoline) and MeIQ (2-amino-2,4-dimethylimidazo[4,5-f]quinoline) in the lacZ reversion mutagenicity test. Enzyme kinetic analyses were performed for N-hydroxylation of five heterocyclic amine substrates and for O-deethylation of phenacetin. The most drastic effect was that of the R431W substitution: no holoenzyme was detectable. This residue is located in the "meander" peptide region and earlier site-directed mutagenesis studies demonstrated that it is critical for maintenance of protein tertiary structure. The ...
Smoking as a Co-Factor for Development of Hepato Cellular Carcinoma in Egyptian Patients with Chronic Hepatitis | MedCrave
Hepato-cellular carcinoma (HCC) is the most frequent primary cancer of liver worldwide. HCC is the seventh most common tumor in males and ninth in females. The annual incidence is estimated to be 1,000,000 newly diagnosed cases . The Middle East, including Egypt, is considered an area of intermediate incidence rate . HCC incidence in Egypt was between 5-7 per 100000 populations per year . HCC is one of the few human cancers for which an etiological factor can be identified in many cases . Hepatic viruses, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of HCC worldwide . Cigarette smoking is a major source of 4-aminobiphenyl, a hepatic carcinogen which has been implicated as a causal risk factor for HCC . Smoking and alcohol drinking were possible risk factors for liver cancer, since many case control studies [24,25] and a few cohort studies [26,27] have indicated a relation between these life style factors and the risk of liver cancer. The ...
2,2'-dimethyl-2,2'-azodipropiononitrile - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
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I just ordered Bob Dale Cut Resistant Goat Skin, driver gloves and Majestic Potentate Double Palm, leather gloves and these gloves are great and was shipped expeditiously. Also affordable price and economical. The driver gloves was soft and nicely fit around my fingers and my leather gloves I used it cleaning my backyard thorny bushes and plants and my leather gloves was comfortable and tough handling those plants and bushes. I will do business again with Glovestock.com in the near future. Thanks, ...
Acetyl coenzyme A-dependent N-acetyltransferase and O-acetyltransferase activities were examined in liver cytosols derived from homozygous rapid acetylator C57BL/6J and A.B6 congenic inbred mouse strains, from homozygous slow acetylator A/J and B6.A congenic inbred mouse strains, and from the (C57BL/6J x A/J)F1 heterozygous acetylator hybrid mouse strain. Acetylator genotype-dependent N-acetyltransferase activity was exhibited for the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl. In contrast, levels of isoniazid N-acetyltransferase and N-hydroxy-3,2-dimethyl-4-aminobiphenyl O-acetyltransferase activities in mouse liver cytosol appeared to be independent of the arylamine Nat acetylator gene. Although cytosolic N-acetyltransferase activities differed about 2-fold between the parental C57BL/6J and A/J strains for p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl, the same N-acetyltransferase activities differed about 6-7-fold between the homozygous rapid ...
Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arachidonic acid, but not upon reduced nicotinamide adenine dinucleotide phosphate. Bladder transitional epithelial microsomes also activated o-dianisidine, 4-aminobiphenyl, and 2-naphthylamine to bind to protein and transfer RNA and benzidine and o-dianisidine to bind DNA. Cosubstrate and inhibitor specificities were consistent with activation by prostaglandin H synthase. Binding of benzidine to protein was not observed with either hepatic or renal cortical microsomes upon addition of arachidonic acid or reduced nicotinamide adenine dinucleotide phosphate.. Prostaglandin H synthase and mixed-function ...
Polypyridil compounds and some of their derivatives have shown to be fruitful ligands in supramolecular photochemistry, due to the capability of its extended π- systems to absorb light. They can act as light harvesters as much as to relax photoexcited metal centres via MLCT to the ligand-centred π*L orbital; some interesting examples can be found in Steed & Atwood, 2009. In particular, in the case of 4,4-dimethyl-2,2-bipyridine (dmbp), the presence of the methyl groups in the aromatic ligand can additionally influence the structural behavior when binding to a metal centre. We present in what follows the crystal and molecular structure of the title compound, C16H18N2O4Zn, consisting of isolated Zn(dmbp)(ac)2, molecules (ac = acetate) bisected by a twofold axis which goes through the Zn(II) cation and halves the organic base through the central C-C bond.. The Zn(II) ion is coordinated by two nitrogen atoms from one molecule of the aromatic base and four oxygen atoms from two bidentate, ...
4-O-alpha-D-galactopyranosyl-D-galactose - digal Summary Report | CureHunter
Determination of carcinogen-DNA adducts by immunoassay<...
TY - JOUR. T1 - Determination of carcinogen-DNA adducts by immunoassay. AU - Poirier, M. C.. AU - Liou, S. H.. AU - Reed, E.. AU - Strickland, P. T.. AU - Tockman, M. S.. PY - 1989/1/1. Y1 - 1989/1/1. UR - http://www.scopus.com/inward/record.url?scp=0024522984&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024522984&partnerID=8YFLogxK. M3 - Review article. C2 - 2664949. AN - SCOPUS:0024522984. VL - 11. SP - 353. EP - 367. JO - Journal of UOEH. JF - Journal of UOEH. SN - 0387-821X. IS - SUPPL.. ER - ...
BENZIDINE (RING-D8, 98%) - Creative Proteomics
NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan<...
TY - JOUR. T1 - NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. AU - Huang, Chi Chou. AU - Chien, Wen Pin. AU - Wong, Ruey Hong. AU - Cheng, Ya Wen. AU - Chen, Meng Cheng. AU - Chou, Ming Chih. AU - Lee, Huei. PY - 2007/7. Y1 - 2007/7. N2 - In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W ...
Enzyme kinetic properties of human recombinant arylamine N-acetyltransferase 2 allotypic variants expressed in Escherichia coli
Arylamine N-acetyltransferase (NAT2) catalyses the N-acetylation of primary arylamine and hydrazine drugs and chemicals. N-Acetylation is subject to polymorphism, and humans can be categorized as either fast or slow acetylators according to their ability to N-acetylate certain arylamine substrates i …
JCI Insight - DNA-encoded bispecific T cell engagers and antibodies present long-term antitumor activity
Another mechanism by which mAbs have antitumor activity is through antibody-dependent cellular cytotoxicity (ADCC). To study the ADCC potential of HER2dMAb, we incubated OVCAR3 cells with or without peripheral blood mononuclear cells (PBMCs), in the presence of sera from HER2dMAb- or empty vector-treated mice. HER2dMAb sera effectively killed the ovarian cancer cells in the presence of PBMCs, similar to commercially available Hu4D5, but not in their absence. No killing was observed in the control sera conditions (Figure 3B and Supplemental Figure 1B) or against HER2-cell lines, such as MDA-MB-231 (Supplemental Figure 1C). Similarly, HER2dMAb showed antibody-dependent phagocytosis activity (Supplemental Figure 1D).. HER2dMAb delays cancer progression in vivo. To determine the antitumor effects of HER2dMAb in vivo, we challenged nude mice with the OVCAR3 ovarian cancer cell line. Nude mice have no T cells but present enhanced NK and macrophage activity (13), and their splenocytes can lyse OVCAR3 ...
CD1d-Based Combination Therapy Eradicates Established Tumors in Mice | The Journal of Immunology
We have made the observation that anti-CD1d mAbs may be useful antitumor agents when used in combination with chemoimmunotherapies and in the context of large established s.c. tumors, like 4T1 and CT26L5, that are controlled by regulatory type II NKT cells. 1DMab (anti-DR5/anti-CD1d/anti-CD137) therapy was more efficacious than TriMab therapy in the eradication of CT26L5 and 4T1 tumors, but less effective against R331 tumors. In this manner, anti-CD1d mAbs are a very effective substitute for anti-CD40 mAbs, particularly when tumors are regulated by CD1d and type II NKT cells. There were no adverse toxicities detected after 1DMab therapy. 1DMab-mediated tumor suppression was dependent on CD8+ T cells, IFN-γ, and CD1d in all three tumor models examined. In seeking an explanation as to why 1DMab was more effective than TriMab in the 4T1 and CT26L5 tumor models, we revealed that although 1DMab and TriMab therapy yielded similarly increased proportions of CD8+ T cells in the tumor DLN producing ...
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008 ...
Unraveling Ambiguous NAT2 Genotyping Data (Brief Communications) su Apple Books
The arylamine N-acetyltransferase 2 (NAT2 ; E.C. 126.96.36.199) is a polymorphic enzyme involved in the metabolism of drugs and aromatic amines. About 50% of white individuals are classified as slow acetylators, and these individuals show impaired metabolism of many therapeutically useful arylamine and…
New approaches to photocatalytic reaction of low concentrations of arylamines in alcohols, Research on Chemical Intermediates |...
3 3 Diaminobenzidine Tetrahydrochloride | Vector Laboratories | Bioz
The Health Effects of Aromatic Amines: A Review - MARC Report Number 35
Phenomenex GC Application #14789: Aromatic Amines on ZB-1701
Cisco电缆调制解调器上的cable-modem dhcp-proxy nat - Cisco
July 2013 - Page 2 of 2 - Nat Kringoudis
List of IARC Group 1 carcinogens - Wikipedia
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, and plants containing them Arsenic and inorganic arsenic compounds1 Asbestos Azathioprine Benzene Benzidine, and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine ...
2017 » SeptemberHealth is Wealth
Blue #1 (E133) and Blue #2 (E132): Banned in Norway, Finland, and France, studies have shown them to cause brain cancer and inhibit nerve-cell development. The colors are found in candy, cereal, soda drinks, sports drinks, and pet food.. • Red #3 (E127) and Red #40 (E129): While Red #3 was banned [in the U.S.] in 1990 for topical use, it can still be sold on the market in our foods and beverages. That should make us all red in the face. Red #40 may contain the carcinogenic contaminant p-Cresidine and is thought to cause tumors of the immune system. In the UK, it is not recommended for children, and it is currently banned in many European nations. The dyes are found in fruit cocktails, maraschino cherries, grenadine, cherry pie mix, ice cream, candy, bakery products, and more.. • Yellow #5 (aka Tartazine, E102): Banned in Norway and Austria, it contains the cancer-causing compounds benzidine and 4-aminobiphenyl. Six of the 11 studies on Yellow #5 showed that it caused genotoxicity, a ...
Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for...
Analysis of p53, p16MTS1, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines. | Base...
Exposure to aromatic amines is considered a major risk factor for the development of bladder cancer. In this study, we have analysed the pattern of point mutations in several tumour genes in 21 cases of bladder cancer arising among western European workers exposed to aromatic amines in an attempt to determine whether this exposure may be...
NIOSHTIC-2 Publications Search - 00093824 - Metabolic Reduction of Benzidine Azo Dyes to Benzidine and its Metabolites and...
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with p
Identification of the N-acetylcysteine conjugate of benzidine...
Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive...
Arsenic can induce reactive oxygen species (ROS) leading to oxidative stress and carcinogenesis. Bladder is one of the major target organs of arsenic, and cyclooxygenase-2 (COX-2) may play an important role in arsenic-induced bladder cancer. However, the mechanism by which arsenic induces COX-2 in bladder cells remains unclear. This study aimed at investigating arsenic-mediated intracellular redox status and signaling cascades leading to COX-2 induction in human uroepithelial cells (SV-HUC-1). SV-HUC-1 cells were exposed to sodium arsenite and COX-2 expression, mitogen-activated protein kinase (MAPK) phosphorylation, glutathione (GSH) levels, ROS induction and Nrf2 expression were quantified. Our results demonstrate that arsenite (1-10 μM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression. Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells. Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. Arsenite
Secondhand smoke - SourceWatch
According to the U.S. Surgeon General, secondhand smoke contains a number of poisonous gases and chemicals, including hydrogen cyanide (used in chemical weapons), carbon monoxide (an odorless, colorless gas found in car exhaust), butane (used in lighter fluid), ammonia (used in household cleaners), and toluene (found in paint thinners). Eleven compounds in tobacco smoke have been identified by the International Agency for Research on Cancer as Group 1 Human Carcinogens. They are: 2-naphthylamine, 4-aminobiphenyl, benzene, vinyl chloride, ethylene oxide, arsenic, beryllium, nickel compounds, chromium, cadmium and polonium-210.. In December 1992 the U.S. Environmental Protection Agency (EPA) issued a risk assessment titled "The Respiratory Health Effects of Passive Smoking," that concluded that secondhand smoke is a known human carcinogen which kills about 3,000 nonsmokers each year and is responsible for up 300,000 cases of bronchitis and pneumonia in children annually. The EPAs study stated ...
Glucuronidation - Wikipedia
Glucuronidation is often involved in xenobiotic metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds. Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase. UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) is an intermediate in the process and is formed in the liver. One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver. The substances resulting from glucuronidation are known as glucuronides (or glucuronosides) and are typically much more water-soluble than the non-glucuronic acid-containing substances from which they were originally synthesised. The human body uses glucuronidation to make a large ...
2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) - Registration Dossier - ECHA
In accordance with Regulation (EC) No 1907/2006, Annex IX, Section 9.2 and 188.8.131.52 as well as 184.108.40.206, Column 2, the simulation test on ultimate degradation in surface water and sediment simulation testing do not need to be conducted as the chemical safety assessment according to Annex I indicates that there is no need to investigate further the degradation of the substance and its degradation products. The risk characterization ratios (RCRs) of the chemical safety assessment are below 1, indicating that the risks are acceptable. Therefore, no biodegradation studies in surface water or sediment will be provided. In addition, due to the results of the tests according to OECD guideline 301C and OECD guideline 302B biodegradation cannot be expected for DMDC in the environment. This finding is supported by the chemical structure of the substance which indicates a low potential for biodegradation. Therefore, no further tests on biodegradation are performed because it is not expected that further ...
Indian Patents. 248765:AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME
Disclosed is an aromatic amine derivative represented by the general formula (1) or (2) below and having a diphenylamino group wherein a cycloalkyl group is bonded to a benzene ring. Also disclosed is an organic electroluminescent device wherein an organic thin film composed of one or more layers including at least a light-emitting layer is interposed between a cathode and an anode, and at least one layer of the organic thin film contains the aromatic amine derivative by itself or as a component of a mixture. This organic electroluminescent device has long life and high luminous efficiency, and is capable of emitting blue light with high color purity. The aromatic amine derivative enables to realize such an organic electroluminescent device. (1) (2) (In the general formula (1), A,sub,1,/sub,-A,sub,4,/sub, respectively represent a hydrogen atom or the like, and a-d respectively represent an integer of 0-5. In this connection, at least one of a-d represents an integer of not less than 1, and in ...
DR. MOINDI STEPHEN KIBET
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- ...
Benzidine (IARC Summary & Evaluation, Volume 1, 1972)
The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with bladder cancer. In the same studies, exposure to 2-naphthylamine alone was similarly associated with bladder cancer. A number of case reports from several countries support the relationship between this neoplasm and occupational exposure to benzidine.. Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987). ...
Patent EP0432929A2 - Polyaniline dispersion and method for making same - Google Patents
A method is provided for the preparation of a conductive composition containing a polymerized aromatic amine wherein the aromatic amine is oxidatively polymerized in an acidic aqueous medium in the presence of an oxidizing agent, a doping agent and an aromatic polyalkyleneoxide in an amount sufficient to stabilize the resulting composition. Preferably, the aromatic amine is aniline or a substituted aniline. Compositions produced by such method are also disclosed. These compositions are useful for treating various substrates to make such substrates conductive.
The biochemistry of aromatic amines. The resistance of some o-aminoaryl sulphates to hydrolysis by aryl sulphatases |...
Prof. Dr. rer. nat. habil. Ulrike Gimsa
N-acetyltransferase 1 (arylamine N-acetyltransferase) Biomolecules | Biocompare
Biomechanics of the Human Urinary Bladder - Roustem N. Miftahof; Hong Gil Nam; | Foyles Bookstore
As a research subject, the biomechanics of the urinary bladder are relatively young, yet medical problems associated with them are as old as mankind. Offering an update on recent achievements in the field, the authors highlight the underlying biological, chemical and physical processes of bladder function and present the systematic development of a mathematical model of the organ as a thin, soft biological shell. The book will be a valuable resource for postgraduate students and researchers interested in the applications of computational mathematics and solid mechanics to modern problems in biomedical engineering and medicine.
Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells. - Semantic Scholar
Electrophilic arylnitrenium ions are considered to be the ultimate reactive intermediates formed by metabolism of mutagenic and carcinogenic arylamines and nitroarenes; they can produce DNA damage by reaction with specific sites on DNA bases. We studied their formation, reactivity and the genotoxic sequelae of their reactions with cellular DNA to understand the mutagenic and carcinogenic activities of arylamines and nitroarenes as a function of their chemical structure. Arylnitrenium ions were generated by the convenient non-metabolic procedure, photolysis of arylazides, to study the reactivity of these ultimate intermediates with DNA, by means of 32P-postlabelling, and the induction of histidine reversions in Salmonella, HPRT mutations and sister chromatid exchange in mammalian (Chinese hamster V79) cells. Good correlations were observed between the DNA-binding potencies and the mutagenic and SCE-inducing potencies of the arylnitrenium ions, among these the nitrenium ions derived from the heterocyclic
Biopartitioning micellar chromatography to pedict mutagenicity of aromatic amines
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability ...
Introducing Your Presidential Candidates | NATA
Chrystal Ace Buffalo Plug
UII - Understanding Invisible Illnesses: February 2011
A few minutes before the meeting and panel were to start, we relocated to the auditorium where we ran through the introduction with the student who had been selected to give it. She introduced us briefly one by one, and each of us stood when she got to our slides and explained a little about what we do in terms of health activism, and also what we were involved in on campus as students (so they could relate to us as whole persons and not just walking talking medical diagnoses). We were brief, intentionally. We wanted to give the audience some context but leave as much time as possible for them to steer the conversation through their questions. All the questions were good ones, and a few were particularly insightful or interesting. One person asked about the experience my brother and I had growing up together, having a sibling to discuss life with an invisible illness with (interestingly, we didnt discuss it growing up, partly because of the nature of my brothers diagnosis of Aspergers. But I ...
... cadmium and 4-aminobiphenyl. Some of the other compounds found in sidestream smoke are: vinylchloride, hydrogen cyanide, ... 4-aminobiphenyl (4-ABP) is an integral component in tobacco smoke, as well as a risk factor for bladder cancer. Sidestream ... Exposure to sidestream smoke yields higher concentrations of these compounds as well as increased concentrations of ... 4-aminobiphenyl, and bladder cancer: two meta-analyses". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1312-20. doi:10.1158/1055- ...
Both palladium and copper complexes of the compound exhibit high activity for the coupling of aryl halides and aryl tosylates ... It is especially efficient and general when employed as a (2-aminobiphenyl)-cyclometalated palladium mesylate precatalyst ... XPhos is an organophosphorus compound derived from biphenyl. Its palladium complexes exhibit high activity for Buchwald-Hartwig ...
List of MeSH codes (D02)
... biphenyl compounds MeSH D02.455.426.559.389.185.060 --- aminobiphenyl compounds MeSH D02.455.426.559.389.185.100 --- benzidines ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ...
One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver ... Generally, an increased rate of glucuronidation results in a loss of potency for the target drugs or compounds. Many drugs ... Al-Zoughool M., Talaska, G. (2006). "4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction ...
2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... In 2004 a known human carcinogen, 4-aminobiphenyl or 4-ABP, was found in some commercial hair dyes. However, evidence is ... The primary intermediates are aromatic para compounds, such as 1,4-diaminobenzene or 4-aminophenol. The coupler compounds ( ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ...
Nicotine itself may serve as a template for further psychoactive compounds. Peak plasma levels of nicotine occur 2-10 min after ... 4-Aminobiphenyl)), and harmala alkaloids. The radioactive element polonium-210 is also known to occur in tobacco smoke. The ... with an even greater removal rate for other classes of compounds (e.g., phenols). Tobacco smoke may be grouped into a ...
The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... The carcinogen 4-Aminobiphenyl can accompany diphenylamine as an impurity. Diphenylamine has low acute and short-term toxicity ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... pubchem.ncbi.nlm.nih.gov/compound/Diphenylamine#section= ...
List of IARC Group 1 carcinogens
Frédéric Y. Bois
Pery A., Bois F., 2009, Adaptation of PBPK model equations to study compound concentration stochasticity in cells and cancer ... The example of 4-aminobiphenyl, Risk Analysis, 15:205-213. Thouand G., Friant P., Bois F., Cartier A., Maul A., Block J.C., ... androgenic compounds, Epidemiology 17(6):S332-S333 Suppl. S. (non refereed) Desmots S., Lecomte A., Robidel F., Dupont O., Bois ...
2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... In 2004 a known human carcinogen, 4-aminobiphenyl or 4-ABP, was found in some commercial hair dyes. However, evidence is ... The primary intermediates are aromatic para compounds, such as 1,4-diaminobenzene or 4-aminophenol. The coupler compounds ( ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ...
belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene ... 4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism ... The metabolites of 4-aminobiphenyl may form adducts with DNA, inducing mutations. 4-Aminobiphenyl and its metabolites may also ... 4-Aminobiphenyl is an amine derivative of biphenyl. It is used to manufacture azo dyes. It is a known human carcinogen and so ...
Quantitative immunohistochemical analysis of 4-aminobiphenyl-DNA in cultured cells and mice: comparison to gas chromatography...
... recognizing 4-aminobiphenyl (4-ABP)--DNA adducts were developed and characterized by competitive enzyme-linked immunosorbent ... Aminobiphenyl Compounds / metabolism* * Animals * Carcinogens / metabolism* * DNA Adducts / analysis* * Enzyme-Linked ... Two monoclonal antisera, 4C11 and 3C8, recognizing 4-aminobiphenyl (4-ABP)--DNA adducts were developed and characterized by ... Quantitative immunohistochemical analysis of 4-aminobiphenyl-DNA in cultured cells and mice: comparison to gas chromatography/ ...
Known and Probable Human Carcinogens
Azoreductase and dye detoxification activities of Bacillus velezensis strain AB
Azo dyes are known to be a very important and widely used class of toxic and carcinogenic compounds. Although lot of research ... Aminobiphenyl Compounds / metabolism * Azo Compounds / metabolism* * Azo Compounds / toxicity * Bacillus / classification * ... Azo dyes are known to be a very important and widely used class of toxic and carcinogenic compounds. Although lot of research ... The culture was found to degrade DR28 to benzidine and 4-aminobiphenyl, both of which are potent mutagens. However, on longer ...
Particularly Hazardous Substances | Environmental Health & Safety | University of Nevada, Reno
M I ʤƾǪ
MEDLINE - Resultado p gina 1
The aromatic compounds 4-aminobiphenyl (ABP) and 4,4-diaminobiphenyl (BZ) are known to have carcinogenic properties. LPO ... 0 (Aminobiphenyl Compounds); 0 (Carcinogens); 0 (DNA Adducts); 0 (Free Radicals); 16054949HJ (4-biphenylamine); EC 1.11.1.- ( ... The binding mode mimicked that of the natural substrate since these compounds did not disturb the water molecule that plays an ... Aromatic compounds are generally highly lipophilic and thus accumulate in highly fatty breast tissues. ...
TNO Repository search for: subject:'Intraperitoneal drug administration'
Aminobiphenyl Compounds · Animal · Carcinoma in Situ · Cell Differentiation · Histocytochemistry · Hyperplasia · Male · ... The new compounds are substantially more lipophilic and much less toxic than the well-known antidote P2S. They reactivate ... Chemicals/CAS: atropine, 51-55-8, 55-48-1; soman, 96-64-0; Atropine, 51-55-8; Organophosphorus Compounds; Oximes; Soman, 96-64- ... Chemicals/CAS: cyproterone acetate, 427-51-0; testosterone propionate, 57-85-2; 2,3-dimethyl-4-aminobiphenyl, 13394-86-0; 9,10 ...
Haz-Map Category Details
Nitrogen Compounds. Synonyms. 1,1-Biphenyl)-4-amine; 4-Amino-1,1-biphenyl; 4-Aminobifenyl [Czech]; 4-Aminobiphenyl; 4- ... 1,1-Biphenyl)-4-amine; 4-Amino-1,1-biphenyl; 4-Aminobifenyl [Czech]; 4-Aminobiphenyl; 4-Aminodifenil [Spanish]; 4- ... p-Aminobiphenyl; p-Aminodiphenyl; p-Biphenylamine; p-Phenylaniline; p-Xenylamine; [ChemIDplus] ... p-Aminobiphenyl; p-Aminodiphenyl; p-Biphenylamine; p-Phenylaniline; p-Xenylamine; [ChemIDplus] ...
2-[[4-[[4-[[6-anilino-1-hydroxy-3-sulpho-2-naph... - Registration Dossier - ECHA
The target chemical should be classified as Amine OR Aromatic compound OR Azo compound OR Hydroxy compound OR Phenol OR ... p-Aminobiphenyl Analogs OR Radical ,, Radical mechanism via ROS formation (indirect) ,, Quinones OR Radical ,, Radical ... Quinone type compounds OR Michael addition ,, Quinone type compounds ,, Quinone methides OR Non-covalent interaction OR Non- ... beta-unsaturated carbonyl compounds OR AN2 ,, Nucleophilic addition to alpha, beta-unsaturated carbonyl compounds ,, alpha, ...
3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyra... - Registration Dossier - ECHA
Quinone type compounds OR Michael addition ,, Quinone type compounds ,, Quinone methides OR Non-covalent interaction OR Non- ... p-Aminobiphenyl Analogs OR Radical ,, Radical mechanism via ROS formation (indirect) ,, Quinones OR Radical ,, Radical ... beta-unsaturated carbonyl compounds OR AN2 ,, Nucleophilic addition to alpha, beta-unsaturated carbonyl compounds ,, alpha, ... Referential boundary: The target chemical should be classified as Anion OR Aromatic compound OR Carbonic acid derivative OR ...
Trisodium... - Registration Dossier - ECHA
... beta-unsaturated carbonyl compounds OR AN2 ,, Michael-type addition on alpha, beta-unsaturated carbonyl compounds ,, Four- and ... p-Aminobiphenyl Analogs OR Radical ,, Radical mechanism via ROS formation (indirect) ,, p-Substituted Mononitrobenzenes OR ... C-Nitroso Compounds OR Radical ,, Radical mechanism via ROS formation (indirect) ,, Conjugated Nitro Compounds OR Radical ,, ... Nucleophilic aromatic substitution on activated aryl and heteroaryl compounds ,, Activated aryl and heteroaryl compounds by ...
SEOM clinical guidelines to primary prevention of cancer (2018) | SpringerLink
Organic nitrogen compounds - physical data
4-Aminobiphenyl. 4-Phenylaniline, Xenylamine. 12. 11. 1. 169.22. 53. 348*. Amine. Alverine. N-ethyl-bis(3-phenylpropyl)-amine. ... Organic nitrogen compounds:. Amine: A compound or functional group that contain a basic nitrogen atom with a lone pair. It can ... Naming of organic compounds - Nomenclature rules for different groups of organic compounds and functional groups, together with ... Organic sulfur compounds - densities - Liquid density of different kinds of organic sulfur compounds with varying carbon number ...
Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats...
The doses of the test compounds were selected based on previous studies (23). All rats were sacrificed at week 60 by ether ... In the current study, we investigated the effects of silymarin on 3,2′-dimethyl-4-aminobiphenyl (DMAB)-initiated prostate ... Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats ... Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats ...
Anti-Viral Compounds - Leivers, Martin Robert
Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I ... 2-[3′-(Cyclopropanecarbonyl-amino)-biphenyl-4-yl]-pyrrolidine-1-carboxylic acid benzyl ester (Compound 4009). A solution of ... 7. A compound of claim 1 wherein V is C and W is N. 8. A compound of claim 1 wherein Z is C(O). 9. A compound of claim 1 ... A compound of claim 11 wherein L1 is a bond. 13. A compound of claim 11 wherein L1 is C2 alkynylene 14. A compound of claim 11 ...
Carcinogens - Cancer-causing Compounds
Here is one place that provides an alphabetized list of those compounds believed to cause cancer in humans. ... 4-Aminobiphenyl (4-aminodiphenyl). 3-Amino-9-ethylcarbazole hydrochloride. 1-Amino-2-methylanthraquinone. 2-Amino-5-(5-nitro-2- ... Carcinogens - Cancer-causing Compounds. Carcinogens - Cancer Causing Compounds. The following list is those compounds which are ... Carcinogens - Cancer-causing Compounds. By EHSO.com, the site for free, objective, practical information about the environment ...
Carcinogens everyday toxins, foods, houses, petroleum, Carcinogens in your house
4-aminobiphenyl. Arsenic and arsenic compounds. Asbestos. Manufacture of auramine. Azathioprine. Benzene. Benzidine. Beryllium ... Lead and lead compounds (inorganic). Magenta (containing CI Basic Red 9). Man-made mineral fibres (see glasswool, rockwool, ... Car paints contain some of the most toxic compounds.. Most people are breathing many carcinogens from the paints that they are ... Chromium compounds (hexavalent). Coal gasification. Coal tar pitches. Coal tars. Coke production. Cyclophosphamide. Cyclosporin ...
The Analysis of Primary Aromatic Amines in Ink Using the ACQUITY UPLC H-Class System with the SQ Detector 2 and MassLynx...
When using the current UPLC conditions the two compounds are not completely resolved giving retention times of 7.71 and 7.76 ... This reduced selectivity can be demonstrated by again considering the PAAs, 2-Aminobiphenyl and 3,3-Dichlorobenzidine in ... Optimum UPLC and SIR conditions were developed, with the elution of all compounds within a 10-minute run. ... When considering individual solvent standards for 2-Aminobiphenyl and 3,3 Dichlorobenzidine, maximum UV absorbance can be ...
Compound Groups | Pharos
Salts of 4-aminobiphenyl. incomplete. This compound group is defined by the SMILES string [CH1]1=[CH1][CH1]=C([CH1]=[CH1]1)C2 ... Compound Groups. COMPOUND GROUP NAME. POPULATION STATUS DATE POPULATED. DESCRIPTION. PROFILE TYPE # MEMBERS. # HAZARDS. ... Toluene Diisocyanate (TDI) Compounds. incomplete. This compound group is defined by the SMILES string CC1=C(C=C(C=C1))N=C=O. ... Tetrabutyltin compounds. in progress. This compound group is defined by the SMILES string [CH3][CH2][CH2][CH2][Sn]([CH2][CH2][ ...
Patent US7556969 - Intensified neutral loss tags and use thereof in mass spectrometry - Google Patents
Detection of Amino-biphenyl using the Method of the Invention. Compound 13 was coupled to 4-aminobiphenyl analyte in the ... The mixture of compound 4 and NHS from the previous step was dissolved in 10 ml dry MeCN. compound 2 (590 mg, 1.9 mmol) was ... As seen, in this case, compound 4 was reacted with the NHS ester of 4-bromobutyric acid to give 11, and the latter compound was ... A mixture of compound 4 and NHS (1:1 mole ratio) was obtained, and was used for further reaction without separation. 1H NMR (CD ...
Health Hazard Alert - Benzidine, o-Tolidine and o-Dianisidine Based Dyes | NIOSH | CDC
As in the case of the o-tolidine-based dyes, a residual amount of the parent compound may be present in the dye. (19) Lynn et ... Benzidine-based dyes may contain residual amounts of benzidine as well as other substances such as 4-aminobiphenyl, an OSHA- ... Cleaning compounds that contain strong reducing agents should not be used because benzidine or other harmful products could be ... The evidence is not definitive in all cases because the parent compound, o-tolidine, may sometimes be present in the dyes as a ...
... nitro compounds, trifluoroborates, and other organics and fine chemicals. ... 4-Aminobiphenyl-3-carboxylic acid. Purity: 96%. [85096-04-4], MFCD03990480. SS-6475. 2-Aminobiphenyl-3-carboxylic acid, HCl. ... 2-Aminobiphenyl-3-carboxylic acid. Purity: 96%. [177171-15-2], MFCD03990478. CA-4866. 3-Aminobiphenyl-3-carboxylic acid. ... Amino-biphenyl-4-yl-acetic acid. Purity: 95%. [221101-61-7], MFCD02662412. QA-0599. 5-Amino-2-([1,1-biphenyl]-2-ylcarbonyl) ...
11 ingredients in U.S. foods so dangerous they're banned in other countries | EmaxHealth
Base de datos CISDOC
Aliphatic nitro compounds 1991. CIS 93-717 Decree No.275/91 of 7 July 1991, regulating particular measures of prevention and of ... 4-aminobiphenyl and its salts; benzidine and its salts; 4-nitrobiphenyl. Even in cases of derogation, protective measures are ... Aliphatic nitro compounds - 1 entrada encontrada. Sus criterios de b squeda son. *Pa s / Organizaci n: Portugal* ...
Secondhand smoke - SourceWatch
They are: 2-naphthylamine, 4-aminobiphenyl, benzene, vinyl chloride, ethylene oxide, arsenic, beryllium, nickel compounds, ... "Secondhand tobacco smoke contains over 4,000 chemical compounds. More than 60 of these are known or suspected to cause cancer ... Eleven compounds in tobacco smoke have been identified by the International Agency for Research on Cancer as Group 1 Human ...
Frontiers | Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia |...
HDAC1- and HDAC3-selective compounds did not show this activity. Using siRNA methods in the FRDA neuronal cells, we show ... HDAC1- and HDAC3- selective compounds did not show this activity. Using siRNA methods in the FRDA neuronal cells, we show ... To understand the mechanism of action of these compounds, we probed the kinetic properties of the active and inactive ... To understand the mechanism of action of these compounds, we probed the kinetic properties of the active and inactive ...
4-Aminobiphenyl - Wikipedia
609. Butylated hydroxytoluene (WHO Food Additives Series 21)
In N-nitroso compounds: Occurence, biological effects, and relevance to human cancer. ONeill, I.K., von Borstel, R.C., Miller ... However, BHT inhibited 3,2-dimethyl-4-aminobiphenyl- and benzidine-induced mutagenicity in the Salmonella test. In a recent ... Reddy, B.S., Hansen, D., Mathews, L., & Sharma, C. (1983a). Effect of micronutrients, antioxidants and related compounds on the ... 4-aminobiphenyl-induced mutagenicity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver S-9 fraction ...
CarcinogensArsenic compoundsFormaldehydeBeryllium compoundsBenzidine and 4-aminobiphenylSubstancesCarcinogenic compoundsCarcinogen 4-aminobiphenylPhenacetin4,000 chemical compoundsDyesLead compoundsAmineBenzoNitro compoundsPhenolic compoundsSalts92671Cancer-causing CToxicityMetabolitesAdductsPotentChemicalsDERIVATIVESCarcinogenicityIsomersMutagenicCigarette smokeToxicChemistryChemicalAmino acidsBladderNitrogenDimethylaminoazobenzeneBariumTobacco
- UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38. (cdc.gov)
- Eleven compounds in tobacco smoke have been identified by the International Agency for Research on Cancer as Group 1 Human Carcinogens. (sourcewatch.org)
- These include the carcinogens 4-aminobiphenyl, benzidine, and dozens of other chemicals. (huffpost.com)
- Chemical carcinogens can be natural chemicals, synthetic compounds or mixtures of both, that are produced or used for industrial, agricultural or commercial purposes. (finder-articles.com)
- In the Pictet-Hubert reaction (1899) the compound is formed in a reaction of the 2-aminobiphenyl - formaldehyde adduct (an N-acyl-o-xenylamine) with zinc chloride at elevated temperatures. (wikipedia.org)
- Also, MHLW proposes to (IV) revise the test methods for household products containing triphenyltin compounds, tributyltin compounds and (V) formaldehyde. (intertek.com)
- Formaldehyde is the most simple aldehydes, is a chemical compound that can be found in tobacco smoke, forest fire, car exhaust, and also in interstellar. (azchemistry.com)
Benzidine and 4-aminobiphenyl2
- This compound group is defined by the SMILES string '[Rh]' and subsequently filtered to remove substances containing '[C]'. For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
- Benzidine-based dyes may contain residual amounts of benzidine as well as other substances such as 4-aminobiphenyl, an OSHA-regulated carcinogen. (cdc.gov)
- MHLW has proposed to (I) designate azo compounds as harmful substances, (II) stipulate the scope of household products containing the azo compounds, and (III) determine the criteria and test methods. (intertek.com)
4,000 chemical compounds2
- There is preliminary evidence that dyes based on o-tolidine and o-dianisidine, except for metalized dyes based on o-dianisidine, may be metabolically converted to the parent compounds. (cdc.gov)
- Dyes manufactured from o-dianisidine and o-tolidine may also contain residual amounts of the respective parent compounds. (cdc.gov)
- Phenanthridine is a nitrogen heterocyclic compound that is the basis of DNA-binding fluorescent dyes through intercalation. (wikipedia.org)
- Though synthetic meals dyes used in meals processing undergo rigorous testing for toxicity by the FDA, some analysis has proven that artificial meals dyes might comprise cancer-causing chemical compounds together with benzidine, 4-aminobiphenyl, and 4-aminoazobenzene. (allergymedicationguide.com)
- Some research discovered that artificial meals dyes might very well be contaminated with cancer-causing chemical compounds. (allergymedicationguide.com)
- Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. (semanticscholar.org)
- 4-Aminobiphenyl is an amine derivative of biphenyl. (wikipedia.org)
- Aberrant crypts, the earliest morphologically evident preneoplastic lesions in chemical colon carcinogenesis, were measured in rapid and slow acetylator congenic Syrian hamsters administered 3,2′-dimethyl-4-aminobiphenyl, an aromatic amine colon carcinogen, to investigate the specific role of the acetylator genotype ( NAT2 ) in colon carcinogenesis. (aacrjournals.org)
- We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. (aacrjournals.org)
- However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. (semanticscholar.org)
- With increasing demand for antioxidant supply in the food, honey had gained vitality since it is rich in phenolic compounds and other antioxidants like ascorbic acid, amino acids, and proteins. (hindawi.com)
- Considerable differences in both composition and content of phenolic compounds have been found in different unifloral honeys [ 18 ]. (hindawi.com)
- A number of compounds, including nicotine, cotinine, and aflatoxin B 1 , are metabolites of the 94% identical CYP2A13 and CYP2A6 enzymes but at different rates. (aspetjournals.org)
- Arbuzov, S., "Synthesis and Pharmacological Investigation of Some New Compounds Related Structurally to Some Natural Metabolites", Conf. (patentgenius.com)
- Aminobiphenyl and its metabolites. (uni-bonn.de)
- Two monoclonal antisera, 4C11 and 3C8, recognizing 4-aminobiphenyl (4-ABP)--DNA adducts were developed and characterized by competitive enzyme-linked immunosorbent assay (ELISA). (nih.gov)
- The enzyme related to the tumorigenicity of these compounds was characterized by a highly specific capacity to form adducts from the acetyl and propionyl derivatives. (aacrjournals.org)
- A further object is to provide active compounds which are potent ligands for nicotinic acetylcholine receptors (nAChR's). (google.com)
- N-Hydroxy-4-aminobiphenyl was a potent direct mutagen in both bacterial strains, N-hydroxy-2-aminobiphenyl was mutagenic in only TA100 while N-hydroxy-3-aminobiphenyl displayed mutagenicity in neither strain. (surrey.ac.uk)
- Compound groups are groups of chemicals that share structural or chemical features. (pharosproject.net)
- This compound group is populated by taking the more general compound group and subtracting the chemicals found in the relevent Annex. (pharosproject.net)
- Because except those three dangerous chemical compounds there are exist several dangerous component that contain chemicals in cigarettes that cause cancer. (azchemistry.com)
- A significant number of the flavour chemicals were aldehydes, a compound class recognised as 'primary irritants' of mucosal tissue of the respiratory tract. (blogspot.com)
- Chemicals are often used to extract these partial-food ingredients, and these compounds leave residues in the food. (huffpost.com)
- The reactivity of the quinol imine derivatives follows the order: 4-hydroxyl more reactive than 4-methoxyl compounds and N-acetyl more reactive than N-benzoyl derivatives. (rti.org)
- In the present studies we investigated the mutagenicity of these three compounds, their N-hydroxy derivatives and their nitrosoderivatives in the Ames test using the Salmonella typhimurium strains TA98 and TA100. (surrey.ac.uk)
- These findings suggest that the weak carcinogenicity of 3-aminobiphenyl may be attributed to the lack of genotoxicity of its N-hydroxyderivative, whereas in the case of 2-aminobiphenyl it may be due to the inability of the hepatic preparations to catalyse its N-hydroxylation, which is in agreement with published in vivo metabolic studies. (surrey.ac.uk)
- Of the three isomers only 4-aminobiphenyl exhibited mutagenicity and only in the presence of an activation system. (surrey.ac.uk)
- It is interesting that of the three isomers only 2-aminobiphenyl is non-planar, forming a dihedral angle of 40 degrees, and this may preclude it from acting as a substrate of the P-450I family of haemoproteins, which selectively catalyses the N-hydroxylation of many aromatic amines including 4-aminobiphenyl. (surrey.ac.uk)
- 1 This study was partially supported by USPHS Grants CA-34627 and CA-48032 (to T. P. P.). A preliminary report of this work was presented at the annual meeting of the American Association for Cancer Research, March, 1995 (57) and the Sixth International Conference on Carcinogenic and Mutagenic N -Substituted Aryl Compounds, November, 1995 (58). (aacrjournals.org)
- Home Milk Allergy Petroleum based Snacks Chemical compounds Linked To ADHD, Nervous System Points, Allergic. (allergymedicationguide.com)
- Furthermore, there could also be risks when extra meals colouring chemical compounds in meals are combined collectively. (allergymedicationguide.com)
- Cigarettes contains a lot of dangerous chemical compounds that can causing cancer. (azchemistry.com)
- Here some chemical compounds found in cigarettes that can cause cancer. (azchemistry.com)
- But this chemical compounds is easily absorbed in blood and brain making the smoker condition worsen day by day. (azchemistry.com)
- The dyeing of hair is an ancient art that involves treatment of the hair with various chemical compounds. (wikipedia.org)
- Mechanisms involving steroid hormones seem plausible because there are fundamental gender differences in production and response to these compounds, and the androgen receptor (AR), estrogen receptors (ER), and progesterone receptors (PR) are expressed in the human bladder ( 7-12 ). (aacrjournals.org)
- Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line. (semanticscholar.org)
- In this study, we have demonstrated that 2-aminobiphenyl (2-ABP) up-regulated the expression of COX-2 in a dose- and time-dependent manner in TSGH-8301 bladder cancer cells. (semanticscholar.org)
- AAS are present in mainstream and side stream tobacco smoke, with the latter containing up to thirty times as much 4-aminobiphenyl (4-ABP) as mainstream smoke (Bryant MS, et al. (cdc.gov)
- Intermediate NH2 radicals, forming during the pyrolysis of ammonia during tobacco combustion, may react with aromatic CH groups (from compounds already present in the tobacco leaves) to form the AAs (Patrianakos, C., et. (cdc.gov)