Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Benzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Methylenebis(chloroaniline): Aromatic diamine used in the plastics industry as curing agent for epoxy resins and urethane rubbers. It causes bladder, liver, lung, and other neoplasms.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Sulfamethazine: A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.Arylamine N-Acetyltransferase: An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.2-Naphthylamine: A naphthalene derivative with carcinogenic action.Toluidines4-Aminobenzoic Acid: An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Fluorenes: A family of diphenylenemethane derivatives.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Carcinogens, Environmental: Carcinogenic substances that are found in the environment.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Glucuronates: Derivatives of GLUCURONIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that include the 6-carboxy glucose structure.Great BritainRisk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Plasminogen Activator Inhibitor 1: A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASESMedroxyprogesterone: (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.Plasminogen Inactivators: Important modulators of the activity of plasminogen activators. The inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.Urokinase-Type Plasminogen Activator: A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.Endotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Confined Spaces: A space which has limited openings for entry and exit combined with unfavorable natural ventilation such as CAVES, refrigerators, deep tunnels, pipelines, sewers, silos, tanks, vats, mines, deep trenches or pits, vaults, manholes, chimneys, etc.Occupational Diseases: Diseases caused by factors involved in one's employment.Occupational Health: The promotion and maintenance of physical and mental health in the work environment.Occupational Health Services: Health services for employees, usually provided by the employer at the place of work.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Database Management Systems: Software designed to store, manipulate, manage, and control data for specific uses.Occupational Medicine: Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Micronucleus Tests: Induction and quantitative measurement of chromosomal damage leading to the formation of micronuclei (MICRONUCLEI, CHROMOSOME-DEFECTIVE) in cells which have been exposed to genotoxic agents or IONIZING RADIATION.Salmonella typhimurium: A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Skin Irritancy Tests: Tests or bioassays that measure the skin sensitization potential of various chemicals.Hair Preparations: Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Clothing: Fabric or other material used to cover the body.Interior Design and Furnishings: The planning of the furnishings and decorations of an architectural interior.BooksLice Infestations: Parasitic attack or subsistence on the skin by members of the order Phthiraptera, especially on humans by Pediculus humanus of the family Pediculidae. The hair of the head, eyelashes, and pubis is a frequent site of infestation. (From Dorland, 28th ed; Stedman, 26th ed)Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Biosimilar Pharmaceuticals: BIOLOGIC PRODUCTS that are imitations but not exact replicas of innovator products.Therapies, Investigational: Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.Awards and PrizesDiffusion of Innovation: The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.Interinstitutional Relations: The interactions between representatives of institutions, agencies, or organizations.

Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2'-dimethyl-4-aminobiphenyl. (1/127)

Aberrant crypt foci (ACF) are preneoplastic lesions for colon cancer. Altered amounts of copper-zinc (CuZnSOD) and manganese (MnSOD) superoxide dismutases have been implicated in multistage carcinogesis of both rodents and humans. Dietary factors are potential modulators of both CuZnSOD and MnSOD activity. The purpose of this study was to investigate the interactive effects of dietary copper, manganese, and iron on 3,2'-dimethyl-4-aminobiphenyl (DMABP)-induced ACF and superoxide dismutase activities in weanling rats fed low or adequate copper (0.8 or 5.1 microg Cu/g diet), low or adequate manganese (0.6 or 17 microg Mn/g diet), and adequate or high iron (37 or 140 microg Fe/g diet). Twelve rats were allowed free access to each of these eight diets for 3.5 wk prior to DMABP administration and for an additional 8 wk after the first DMABP injection. Rats fed low dietary copper had 105% (P < 0.0001) higher formation of DMABP-induced ACF than those fed adequate dietary copper. Rats ingesting low rather than adequate dietary manganese had 23% higher formation of ACF, and rats ingesting high rather than adequate dietary iron had 18% higher formation of ACF. Heart total superoxide dismutase activity was significantly correlated with the number of ACF (r = -0.43, P < 0.0001) in rats administered DMABP. These results suggest that dietary alterations that affect superoxide dismutase activity may affect cancer susceptibility.  (+info)

Molecular and genetic damage from environmental tobacco smoke in young children. (2/127)

To assess the risks of early life exposure to environmental tobacco smoke (ETS), we tested whether four biomarkers in peripheral blood were associated with home ETS exposure in Hispanic and African-American children. The biomarkers included cotinine (a metabolite of nicotine) and three indicators of molecular and genetic damage from mutagens/carcinogens, protein adducts formed by the carcinogens 4-aminobiphenyl (4-ABP) and polycyclic aromatic hydrocarbons (PAHs), and sister chromatid exchanges (SCEs). We also explored possible ethnic differences in biomarkers. The study cohort comprised 109 Hispanic and African-American preschool children (1-6 years of age). Plasma cotinine was analyzed by gas chromatography, 4-ABP-hemoglobin adducts by gas chromatography-mass spectroscopy, PAH-albumin adducts by ELISA, and SCEs by cytogenetic techniques. Data on the amount of smoking by mothers (average 10.5 cigarettes per day) and other household members and regular visitors (average 6.5 cigarettes per day) were obtained by interview-administered questionnaires. Cotinine, 4-ABP-hemoglobin adducts, and PAH-albumin were significantly higher (P < 0.05) in the ETS-exposed children compared with the unexposed. SCEs were marginally higher (P = 0.076). African-American children had higher levels of cotinine (P = 0.059) and PAH-albumin (P = 0.02) than Hispanic children, after controlling for exposure to ETS. These results indicate molecular and genetic damage in minority children with  (+info)

Quantitative analysis of 4-aminobiphenyl-C8-deoxyguanosyl DNA adducts produced in vitro and in vivo using HPLC-ES-MS. (3/127)

Electrospray mass spectrometry (ES-MS) is a powerful tool for analysis of carcinogen-adducted DNA. In this study, we developed a quantitative isotope dilution method for analysis of N-(deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-4-ABP), the principal nucleoside adduct derived from enzymatic hydrolysis of 4-aminobiphenyl (4-ABP)-modified DNA. The method used column switching valves to perform on-line sample concentration and cleanup, which permitted direct analysis of enzymatic DNA hydrolysates using narrow-bore liquid chromatography (LC). ES-MS detection was performed using a single quadrupole instrument by monitoring M+H+ and two fragment ions characteristic for dG-C8-4-ABP, along with M+H+ and a fragment ion for the deuterated internal standard. The detection limit for dG-C8-4-ABP in DNA hydrolysates was approximately 10 pg on-column, equivalent to 0.7 dG-C8-4-ABP adducts in 10(7) normal nucleotides for a sample containing 100 microg DNA. The method was applied to the analysis of calf thymus DNA modified in vitro through reaction with N-hydroxy-4-ABP and of hepatic DNA isolated from mice treated in vivo with two dose levels of 4-ABP.  (+info)

Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. (4/127)

Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N'-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-N,N'-diacetylbenzidine, 3-hydroxy-benzidine, 4-aminobiphenyl, N-hydroxy-4-aminobiphenyl, and N-hydroxy-N-acetyl-4-aminobiphenyl. The (3)H- and (14)C-labeled glucuronides were prepared with human or rat liver microsomes using UDP-glucuronic acid as cosubstrate. Each of the 10 glucuronides (6-12 microM) was incubated at pH 5.5 or 7.0 with either human recombinant (pure) or E. coli (commercial preparation) beta-glucuronidase for 30 min at 37 degrees C. Hydrolysis was measured by HPLC. Reaction conditions were optimized, using the O-glucuronide of N-hydroxy-N,N'-diacetylbenzidine. Both enzymes preferentially hydrolyzed O-glucuronides over N-glucuronides and distinguished between structural isomers. With E. coli beta-glucuronidase at pH 7.0, selectivity was demonstrated by the complete hydrolysis of N-hydroxy-N-acetyl-4-aminobiphenyl O-glucuronide in the presence of N-acetylbenzidine N-glucuronide, which was not hydrolyzed. Metabolism by both enzymes was completely inhibited by the specific beta-glucuronidase inhibitor saccharic acid-1,4-lactone (0.5 mM). The concentration of human beta-glucuronidase necessary to achieve significant hydrolysis of glucuronides was substantially more than the amount of enzyme reported previously to be present in urine under either normal or pathological conditions. The bacterial enzyme may hydrolyze O-glucuronides, but not N-glucuronides, in urine at neutral pH. Thus, the nonenzymatic hydrolysis of N-glucuronides by acidic urine is likely a more important source of free amine than enzymatic hydrolysis.  (+info)

CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice. (5/127)

4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. Hemoglobin adducts and lung DNA adducts of 4-ABP are found in tobacco smokers. In vitro metabolism studies with human and rat liver microsomes have shown that CYP1A2 is primarily responsible for catalyzing N-hydroxylation, the initial step in the metabolic activation of 4-ABP. To determine whether this P450 is a rate limiting pathway for hepatocarcinogenesis, CYP1A2-null mice were analyzed at 16 months of age and were compared with wild-type mice in their response to 4-ABP using the neonatal mouse bioassay and two different doses of the carcinogen. Overall differences in incidences of hepatocellular adenoma, carcinoma and preneoplastic foci were not significant between either genotypes or 4-ABP doses used, whereas small, but significant, differences were found for specific types of foci. These results suggest that while CYP1A2 levels may not be rate limiting for 4-ABP metabolism to produce tumors and foci, it may modulate the induction process of some types of liver foci in either a positive or negative manner. In vitro studies using CYP1A2-null and wild-type mouse liver microsomes revealed that CYP1A2 is not the sole P450 required for 4-ABP N-hydroxylation and that another, yet to be identified, P450 is likely to be involved.  (+info)

Mortalities of workers at the Nitro plant with exposure to 2-mercaptobenzothialzole. (6/127)

OBJECTIVES: An update of a study of workers exposed to 2-mercaptobenzothiazole (MBT) at a rubber chemicals plant in Nitro, West Virginia is reported. The earlier study found high rates of lung cancer, prostate cancer, and bladder cancer in these workers who also had potential exposure to 4-aminobiphenyl (PAB), a potent bladder carcinogen. METHODS: This cohort mortality study examines the mortalities of 1059 full time white male production workers employed at the plant from 1955 to 1977. A detailed exposure assessment was done on the 600 workers with exposure to MBT. Nine years of additional follow up to the previous study are added. RESULTS: It was found that MBT workers have expected rates of lung (standardised mortality ratio (SMR) = 1.0 95% confidence interval (95% CI) 0.7 to 1.5) and prostate (SMR = 0.9, 95% CI 0.2 to 2.3) cancer. There was an excess of bladder cancer among MBT workers who had definite exposure to PAB (SMR = 27.1, 95% CI 11.7 to 53.4), and MBT workers with potential exposure to PAB (SMR = 4.3, 95% CI 1.4 to 10.0). However, there were no deaths from bladder cancer among workers with no exposure to PAB (SMR = 0.0, 95% CI 0.0 to 24.7), although there were only 0.2 deaths expected. CONCLUSIONS: The potential confounding of exposure to an unknown portion of PAB in the MBT workers makes it impossible to evaluate risk of bladder cancer in this population at this time. However, exposure to MBT does not seem to increase the risk of most cancers including cancers of the lung and prostate.  (+info)

Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism. (7/127)

Mitochondrial dihydroorotate dehydrogenase (DHOdehase; EC 1.3.99.11) is a target of anti-proliferative, immunosuppressive and anti-parasitic agents. Here, redoxal, (2,2'-[3,3'-dimethoxy[1, 1'-biphenyl]-4,4'-diyl)diimino]bis-benzoic acid, was studied with isolated mitochondria and the purified recombinant human and rat enzyme to find out the mode of kinetic interaction with this target. Its pattern of enzyme inhibition was different from that of cinchoninic, isoxazol and naphthoquinone derivatives and was of a non-competitive type for the human (K(ic)=402 nM; K(iu)=506 nM) and the rat enzyme (K(ic)=116 nM; K(iu)=208 nM). The characteristic species-related inhibition of DHOdehase found with other compounds was less expressed with redoxal. In human and rat mitochondria, redoxal did not inhibit NADH-induced respiration, its effect on succinate-induced respiration was marginal. This was in contrast to the sound effect of atovaquone and dichloroallyl-lawsone, studied here for comparison. In human mitochondria, the IC(50) value for the inhibition of succinate-induced respiration by atovaquone was 6.1 microM and 27.4 microM for the DHO-induced respiration; for dichlorallyl-lawsone, the IC(50) values were 14.1 microM and 0.23 microM.  (+info)

N-acetyltransferase 2 phenotype but not NAT1*10 genotype affects aminobiphenyl-hemoglobin adduct levels. (8/127)

Aminobiphenyls (ABPs) in tobacco have been implicated in bladder cancer etiology in smokers. N-Acetylation of ABPs in the liver, predominantly by the N-acetyltransferase 2 (NAT2) isozyme, represents a detoxification pathway, whereas O-acetylation of N-hydroxy-ABPs in the bladder, predominantly by the N-acetyltransferase 1 (NAT1) isozyme, represents a bioactivation pathway. We and others have demonstrated that NAT2 phenotype affects 3- and 4-ABP-hemoglobin adduct levels (higher levels in slow acetylators), which are considered valid biomarkers of the internal dose of ABP to the bladder. We have also shown that NAT1 genotype (NAT1*10 allele) is associated with increased DNA adduct levels in urothelial tissue and higher risk of bladder cancer among smokers. It is not known whether NAT1*10 genotype influences ABP-hemoglobin adduct levels. Therefore, we assessed 403 primarily non-Hispanic white residents of Los Angeles County for their NAT2 acetylator phenotype, NAT1*10 acetylator genotype, and 3- and 4-ABP-hemoglobin adduct levels. Eighty-two subjects were current tobacco smokers of varying intensities. Tobacco smokers had significantly higher mean 3- and 4-ABP-hemoglobin adduct levels relative to nonsmokers. The levels increased with increased amounts smoked per day (two-sided, P < 0.0001 in all cases). With adjustment for NAT1 genotype and race, the smoking-adjusted geometric mean level of 3-ABP-hemoglobin adducts in NAT2 slow acetylators was 47% higher than that in NAT2 rapid acetylators (P = 0.01). The comparable value for 4-ABP-hemoglobin adducts was 17% (P = 0.02). In contrast, no association between NAT1*10 genotype and 3- or 4 ABP-hemoglobin adduct levels was observed after adjustment for NAT2 phenotype, smoking, and race. The present study suggests that the impact of the NAT1*10 genotype on 3- and 4-ABP-hemoglobin adducts is noninformative on the possible association between NAT1 activity and bladder cancer risk.  (+info)

4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism is catalyzed by N-hydroxylation via cytochrome P450 1A2. It is then followed by O-sulfation and O-acetylation by sulfotransferase 1A1 and arylamine N-acetyltransferase 2. The urinary metabolites of 4-aminobiphenyl include 4-acetylaminobiphenyl, 4-hydroxy-4-aminobiphenyl, 2-hydroxy-4-acetylaminobiphenyl, 4-hydroxy-4-acetylaminobiphenyl, 3-hydroxy, 4-methoxy-4-acetylaminobiphenyl, 4-hydroxy, 3-methoxy-4-acetylaminobiphenyl, and 3,4-dihydroxy-4-acetylaminobiphenyl. (8, 4 ...
A multistep in vitro/in vivo transformation system was used to test the transforming effect(s) of the human bladder procarcinogen 4-aminobiphenyl (ABP) and two putative proximate carcinogenic metabolites, N-hydroxy-4-aminobiphenyl (N-OH-ABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP), on a clonally derived nontumorigenic SV40-immortalized human uroepithelial cell line, SV-HUC. SV-HUC were exposed in vitro to concentrations of ABP, N-OH-ABP, or N-OH-AABP that caused a range of cytotoxicity from 5 to 76%. Tumorigenic transformation of SV-HUC, as assessed by the ability of the exposed cells to form carcinomas when inoculated s.c. into athymic nude mice, was achieved after a single exposure to ABP, N-OH-ABP, or N-OH-AABP. In the tumorigenic transformation experiments, 28 of 45 mice representing all 15 carcinogen-exposed observation groups formed carcinomas, whereas none of 9 mice from control groups formed carcinomas (P = 0.001). Neoplastic progression of a low grade regressive squamous cell ...
3,5-Dimethyl-3-(4-fluorophenyl)propiophenone/ACM898768406 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Zhou H., Josephy P.D., Kim D., Guengerich F.P.. Human cytochrome P450 1A2 catalyzes important reactions in xenobiotic metabolism, including the N-hydroxylation of carcinogenic aromatic amines. In 2001, Chevalier et al. reported four new P450 1A2 sequence variants in the human population. We have now expressed these variants in Escherichia coli and measured protein expression (optical spectroscopy of holoenzyme and immunoblotting) and bioactivation of IQ (2-amino-3-methylimidazo[4,5-f]quinoline) and MeIQ (2-amino-2,4-dimethylimidazo[4,5-f]quinoline) in the lacZ reversion mutagenicity test. Enzyme kinetic analyses were performed for N-hydroxylation of five heterocyclic amine substrates and for O-deethylation of phenacetin. The most drastic effect was that of the R431W substitution: no holoenzyme was detectable. This residue is located in the "meander" peptide region and earlier site-directed mutagenesis studies demonstrated that it is critical for maintenance of protein tertiary structure. The ...
Hepato-cellular carcinoma (HCC) is the most frequent primary cancer of liver worldwide. HCC is the seventh most common tumor in males and ninth in females. The annual incidence is estimated to be 1,000,000 newly diagnosed cases [2]. The Middle East, including Egypt, is considered an area of intermediate incidence rate [9]. HCC incidence in Egypt was between 5-7 per 100000 populations per year [21]. HCC is one of the few human cancers for which an etiological factor can be identified in many cases [9]. Hepatic viruses, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of HCC worldwide [22]. Cigarette smoking is a major source of 4-aminobiphenyl, a hepatic carcinogen which has been implicated as a causal risk factor for HCC [23]. Smoking and alcohol drinking were possible risk factors for liver cancer, since many case control studies [24,25] and a few cohort studies [26,27] have indicated a relation between these life style factors and the risk of liver cancer. The ...
Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339- ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
I just ordered Bob Dale Cut Resistant Goat Skin, driver gloves and Majestic Potentate Double Palm, leather gloves and these gloves are great and was shipped expeditiously. Also affordable price and economical. The driver gloves was soft and nicely fit around my fingers and my leather gloves I used it cleaning my backyard thorny bushes and plants and my leather gloves was comfortable and tough handling those plants and bushes. I will do business again with Glovestock.com in the near future. Thanks, ...
Acetyl coenzyme A-dependent N-acetyltransferase and O-acetyltransferase activities were examined in liver cytosols derived from homozygous rapid acetylator C57BL/6J and A.B6 congenic inbred mouse strains, from homozygous slow acetylator A/J and B6.A congenic inbred mouse strains, and from the (C57BL/6J x A/J)F1 heterozygous acetylator hybrid mouse strain. Acetylator genotype-dependent N-acetyltransferase activity was exhibited for the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl. In contrast, levels of isoniazid N-acetyltransferase and N-hydroxy-3,2-dimethyl-4-aminobiphenyl O-acetyltransferase activities in mouse liver cytosol appeared to be independent of the arylamine Nat acetylator gene. Although cytosolic N-acetyltransferase activities differed about 2-fold between the parental C57BL/6J and A/J strains for p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl, the same N-acetyltransferase activities differed about 6-7-fold between the homozygous rapid ...
Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arachidonic acid, but not upon reduced nicotinamide adenine dinucleotide phosphate. Bladder transitional epithelial microsomes also activated o-dianisidine, 4-aminobiphenyl, and 2-naphthylamine to bind to protein and transfer RNA and benzidine and o-dianisidine to bind DNA. Cosubstrate and inhibitor specificities were consistent with activation by prostaglandin H synthase. Binding of benzidine to protein was not observed with either hepatic or renal cortical microsomes upon addition of arachidonic acid or reduced nicotinamide adenine dinucleotide phosphate.. Prostaglandin H synthase and mixed-function ...
Polypyridil compounds and some of their derivatives have shown to be fruitful ligands in supramolecular photochemistry, due to the capability of its extended π- systems to absorb light. They can act as light harvesters as much as to relax photoexcited metal centres via MLCT to the ligand-centred π*L orbital; some interesting examples can be found in Steed & Atwood, 2009. In particular, in the case of 4,4-dimethyl-2,2-bipyridine (dmbp), the presence of the methyl groups in the aromatic ligand can additionally influence the structural behavior when binding to a metal centre. We present in what follows the crystal and molecular structure of the title compound, C16H18N2O4Zn, consisting of isolated Zn(dmbp)(ac)2, molecules (ac = acetate) bisected by a twofold axis which goes through the Zn(II) cation and halves the organic base through the central C-C bond.. The Zn(II) ion is coordinated by two nitrogen atoms from one molecule of the aromatic base and four oxygen atoms from two bidentate, ...
4-O-alpha-D-galactopyranosyl-D-galactose: carbohydrate part of receptor on human uroepithelial cells; RN given refers to (alpha-D,D)-isomer
TY - JOUR. T1 - Determination of carcinogen-DNA adducts by immunoassay. AU - Poirier, M. C.. AU - Liou, S. H.. AU - Reed, E.. AU - Strickland, P. T.. AU - Tockman, M. S.. PY - 1989/1/1. Y1 - 1989/1/1. UR - http://www.scopus.com/inward/record.url?scp=0024522984&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024522984&partnerID=8YFLogxK. M3 - Review article. C2 - 2664949. AN - SCOPUS:0024522984. VL - 11. SP - 353. EP - 367. JO - Journal of UOEH. JF - Journal of UOEH. SN - 0387-821X. IS - SUPPL.. ER - ...
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TY - JOUR. T1 - NAT2 fast acetylator genotype is associated with an increased risk of colorectal cancer in Taiwan. AU - Huang, Chi Chou. AU - Chien, Wen Pin. AU - Wong, Ruey Hong. AU - Cheng, Ya Wen. AU - Chen, Meng Cheng. AU - Chou, Ming Chih. AU - Lee, Huei. PY - 2007/7. Y1 - 2007/7. N2 - In Taiwan, colorectal cancer has one of the highest rates of increased incidence in the past two decades. Heterocyclic amines from dietary cooked meats are metabolically activated by NAT2 (N-acetyltransferase 2), which are associated with colorectal cancer incidence. Thus, the NAT2 fast acetylator genotype may be associated with colorectal cancer risk. However, the association between the NAT2 genotype and colorectal cancer risk is not clearly understood. We conducted a study with 244 primary colorectal cancer cases and 299 cancer-free healthy control subjects to verify the association of NAT2 polymorphisms with the risk of Taiwanese colorectal cancer. Our data showed that subjects with the NAT2 W/W ...
Another mechanism by which mAbs have antitumor activity is through antibody-dependent cellular cytotoxicity (ADCC). To study the ADCC potential of HER2dMAb, we incubated OVCAR3 cells with or without peripheral blood mononuclear cells (PBMCs), in the presence of sera from HER2dMAb- or empty vector-treated mice. HER2dMAb sera effectively killed the ovarian cancer cells in the presence of PBMCs, similar to commercially available Hu4D5, but not in their absence. No killing was observed in the control sera conditions (Figure 3B and Supplemental Figure 1B) or against HER2-cell lines, such as MDA-MB-231 (Supplemental Figure 1C). Similarly, HER2dMAb showed antibody-dependent phagocytosis activity (Supplemental Figure 1D).. HER2dMAb delays cancer progression in vivo. To determine the antitumor effects of HER2dMAb in vivo, we challenged nude mice with the OVCAR3 ovarian cancer cell line. Nude mice have no T cells but present enhanced NK and macrophage activity (13), and their splenocytes can lyse OVCAR3 ...
We have made the observation that anti-CD1d mAbs may be useful antitumor agents when used in combination with chemoimmunotherapies and in the context of large established s.c. tumors, like 4T1 and CT26L5, that are controlled by regulatory type II NKT cells. 1DMab (anti-DR5/anti-CD1d/anti-CD137) therapy was more efficacious than TriMab therapy in the eradication of CT26L5 and 4T1 tumors, but less effective against R331 tumors. In this manner, anti-CD1d mAbs are a very effective substitute for anti-CD40 mAbs, particularly when tumors are regulated by CD1d and type II NKT cells. There were no adverse toxicities detected after 1DMab therapy. 1DMab-mediated tumor suppression was dependent on CD8+ T cells, IFN-γ, and CD1d in all three tumor models examined. In seeking an explanation as to why 1DMab was more effective than TriMab in the 4T1 and CT26L5 tumor models, we revealed that although 1DMab and TriMab therapy yielded similarly increased proportions of CD8+ T cells in the tumor DLN producing ...
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008 ...
‎The arylamine N-acetyltransferase 2 (NAT2 [5]; E.C. 2.3.1.5) is a polymorphic enzyme involved in the metabolism of drugs and aromatic amines. About 50% of white individuals are classified as slow acetylators, and these individuals show impaired metabolism of many therapeutically useful arylamine and…
Read "New approaches to photocatalytic reaction of low concentrations of arylamines in alcohols, Research on Chemical Intermediates" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
GC Application #14789: Aromatic Amines on ZB-1701. Column used: Zebron™ ZB-1701, GC Cap. Column 30 m x 0.25 mm x 0.25 µm, Ea Part#: 7HG-G006-11
This review discusses the current slate of knowledge regarding the potential human health hazard following exposure to aromatic amines.. ...
本文解释如何使用cable-modem dhcp-proxy nat命令。此命令主要功能将配置一个网络地址转换(NAT)地址池用Intrernet供应商的DHCP服务器供应的IP地址。
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, and plants containing them Arsenic and inorganic arsenic compounds1 Asbestos Azathioprine Benzene Benzidine, and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine ...
Blue #1 (E133) and Blue #2 (E132): Banned in Norway, Finland, and France, studies have shown them to cause brain cancer and inhibit nerve-cell development. The colors are found in candy, cereal, soda drinks, sports drinks, and pet food.. • Red #3 (E127) and Red #40 (E129): While Red #3 was banned [in the U.S.] in 1990 for topical use, it can still be sold on the market in our foods and beverages. That should make us all red in the face. Red #40 may contain the carcinogenic contaminant p-Cresidine and is thought to cause tumors of the immune system. In the UK, it is not recommended for children, and it is currently banned in many European nations. The dyes are found in fruit cocktails, maraschino cherries, grenadine, cherry pie mix, ice cream, candy, bakery products, and more.. • Yellow #5 (aka Tartazine, E102): Banned in Norway and Austria, it contains the cancer-causing compounds benzidine and 4-aminobiphenyl. Six of the 11 studies on Yellow #5 showed that it caused genotoxicity, a ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Exposure to aromatic amines is considered a major risk factor for the development of bladder cancer. In this study, we have analysed the pattern of point mutations in several tumour genes in 21 cases of bladder cancer arising among western European workers exposed to aromatic amines in an attempt to determine whether this exposure may be...
Information about the carcinogenicity of benzidine (92875) in man and in experimental animals is reviewed, along with results of studies on the metabolism of benzidine and azo compounds, and epidemiological surveys of industries that use azo dyes. The author concludes that workers exposed to benzidine based dyes may metabolically convert the dyes to carcinogenic amine. The number of workers with p
Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system.: Benzidine is oxidized by the peroxidase/H2O2 system,
Arsenic can induce reactive oxygen species (ROS) leading to oxidative stress and carcinogenesis. Bladder is one of the major target organs of arsenic, and cyclooxygenase-2 (COX-2) may play an important role in arsenic-induced bladder cancer. However, the mechanism by which arsenic induces COX-2 in bladder cells remains unclear. This study aimed at investigating arsenic-mediated intracellular redox status and signaling cascades leading to COX-2 induction in human uroepithelial cells (SV-HUC-1). SV-HUC-1 cells were exposed to sodium arsenite and COX-2 expression, mitogen-activated protein kinase (MAPK) phosphorylation, glutathione (GSH) levels, ROS induction and Nrf2 expression were quantified. Our results demonstrate that arsenite (1-10 μM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression. Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells. Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. Arsenite
According to the U.S. Surgeon General, secondhand smoke contains a number of poisonous gases and chemicals, including hydrogen cyanide (used in chemical weapons), carbon monoxide (an odorless, colorless gas found in car exhaust), butane (used in lighter fluid), ammonia (used in household cleaners), and toluene (found in paint thinners). Eleven compounds in tobacco smoke have been identified by the International Agency for Research on Cancer as Group 1 Human Carcinogens. They are: 2-naphthylamine, 4-aminobiphenyl, benzene, vinyl chloride, ethylene oxide, arsenic, beryllium, nickel compounds, chromium, cadmium and polonium-210.[2]. In December 1992 the U.S. Environmental Protection Agency (EPA) issued a risk assessment titled "The Respiratory Health Effects of Passive Smoking," that concluded that secondhand smoke is a known human carcinogen which kills about 3,000 nonsmokers each year and is responsible for up 300,000 cases of bronchitis and pneumonia in children annually. The EPAs study stated ...
Glucuronidation is often involved in xenobiotic metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds. Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase. UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) is an intermediate in the process and is formed in the liver. One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver. The substances resulting from glucuronidation are known as glucuronides (or glucuronosides) and are typically much more water-soluble than the non-glucuronic acid-containing substances from which they were originally synthesised. The human body uses glucuronidation to make a large ...
Aminoglutethimide (AG) 500 mg was administered orally to four normal volunteers and eight patients undergoing treatment for metastatic breast cancer. In each subject the acetylator phenotype was established from the monoacetyldapsone (MADDS)/dapsone (DDS) ratio. Acetylaminoglutethimide (acetylAG) rapidly appeared in the plasma and its disposition paralleled that of AG. A close relationship (P less than 0.01) was observed between the acetyl AG/AG and MADDS/DDS ratio suggesting that AG may undergo polymorphic acetylation like DDS. AG half-life was 19.5 +/- 7.7 h in seven fast acetylators of DDS and 12.6 +/- 2.3 h in five slow acetylators and its apparent metabolic clearance was significantly (P less than 0.01) related to the acetylAG/AG ratio. Over 48 h the fast acetylators excreted 7.7 +/- 4.4% of the administered AG dose in the urine as unchanged AG as compared to 12.4 +/- 2.8% in slow acetylators. A much smaller fraction of the dose was excreted as acetylAG: 3.6 +/- 1.5% by fast and 1.9 +/- ...
The epidemiological studies showed that occupational exposure to commercial benzidine alone was strongly associated with bladder cancer. In the same studies, exposure to 2-naphthylamine alone was similarly associated with bladder cancer. A number of case reports from several countries support the relationship between this neoplasm and occupational exposure to benzidine.. Subsequent evaluations: Vol. 29 (1982); Suppl. 7 (1987). ...
A method is provided for the preparation of a conductive composition containing a polymerized aromatic amine wherein the aromatic amine is oxidatively polymerized in an acidic aqueous medium in the presence of an oxidizing agent, a doping agent and an aromatic polyalkyleneoxide in an amount sufficient to stabilize the resulting composition. Preferably, the aromatic amine is aniline or a substituted aniline. Compositions produced by such method are also disclosed. These compositions are useful for treating various substrates to make such substrates conductive.
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
As a research subject, the biomechanics of the urinary bladder are relatively young, yet medical problems associated with them are as old as mankind. Offering an update on recent achievements in the field, the authors highlight the underlying biological, chemical and physical processes of bladder function and present the systematic development of a mathematical model of the organ as a thin, soft biological shell. The book will be a valuable resource for postgraduate students and researchers interested in the applications of computational mathematics and solid mechanics to modern problems in biomedical engineering and medicine.
Electrophilic arylnitrenium ions are considered to be the ultimate reactive intermediates formed by metabolism of mutagenic and carcinogenic arylamines and nitroarenes; they can produce DNA damage by reaction with specific sites on DNA bases. We studied their formation, reactivity and the genotoxic sequelae of their reactions with cellular DNA to understand the mutagenic and carcinogenic activities of arylamines and nitroarenes as a function of their chemical structure. Arylnitrenium ions were generated by the convenient non-metabolic procedure, photolysis of arylazides, to study the reactivity of these ultimate intermediates with DNA, by means of 32P-postlabelling, and the induction of histidine reversions in Salmonella, HPRT mutations and sister chromatid exchange in mammalian (Chinese hamster V79) cells. Good correlations were observed between the DNA-binding potencies and the mutagenic and SCE-inducing potencies of the arylnitrenium ions, among these the nitrenium ions derived from the heterocyclic
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity. Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability ...
Sizes available: 12, 14, 16mm ABP1: Red Heart ABP2: Red Diamond ABP3: Black Club ABP4: Black Spade Please specify design code, color and size o
A few minutes before the meeting and panel were to start, we relocated to the auditorium where we ran through the introduction with the student who had been selected to give it. She introduced us briefly one by one, and each of us stood when she got to our slides and explained a little about what we do in terms of health activism, and also what we were involved in on campus as students (so they could relate to us as whole persons and not just walking talking medical diagnoses). We were brief, intentionally. We wanted to give the audience some context but leave as much time as possible for them to steer the conversation through their questions. All the questions were good ones, and a few were particularly insightful or interesting. One person asked about the experience my brother and I had growing up together, having a sibling to discuss life with an invisible illness with (interestingly, we didnt discuss it growing up, partly because of the nature of my brothers diagnosis of Aspergers. But I ...
In humans, the metabolism of a number of tertiary amine-containing pharmacological agents to quaternary ammonium-linked glucuronides, catalyzed by UDP-glucuronosyltransferase (UGT), represents a unique and important metabolic pathway for these compounds. A full-length cDNA-encoding human UGT1.4 (the so-called "minor" human bilirubin UGT) was inserted into the expression vector pREP9 and transfected into human embryonic kidney 293 cells, and stable transfectants were obtained after geneticin selection. As expected, the expressed protein had low catalytic activity toward bilirubin. However, expressed human UGT1.4 protein exhibited glucuronidation activity toward tertiary amine substrates, such as imipramine, cyproheptadine, tripelennamine, and chlorpromazine, which form quaternary ammonium-linked glucuronides. Carcinogenic primary amines (beta-naphthylamine, benzidine, and 4-aminobiphenyl) also reacted with the expressed UGT1.4 protein at rates approximately 10-fold higher than the rates for ...
Looking for bladder cell? Find out information about bladder cell. Any of the large vacuolated cells in the outer layers of the tunic in some tunicates Explanation of bladder cell
There has been a surge of interest in the surface-enhanced Raman scattering (SERS) of p-aminothiophenol (PATP), since its SERS spectra are dependent on the measurement conditions. However, there is a dispute over the origin of the so-called b2 modes in SERS spectrum of PATP recently. Some researchers propose that these bands come from selective chemical enhancement, while others conclude that these bands are due to the ag modes of p,p-dimercaptoazobenzene (DMAB) produced from PATP by surface photoreaction. To solve this problem, we have studied the SERS spectra of PATP on Au and Ag nanoparticles by in situ measurement under various conditions. The results proved that the b2 modes are not due to PATP but due to the ag modes of DMAB. The key of the method is to ensure the SERS spectra taken from the same point in reduplicative measurements. The result showed that the stable SERS spectrum of PATP was essentially from DMAB. The reversibility of the PATP SERS spectra in previous studies is due to ...
Since 2011, denosumab (Dmab) subcutaneous (SC) injection is available as a superior treatment option in patients with bone metastases from solid tumours, compared with zoledronic acid (Zol) administered as an intravenous (IV) infusion. Although Zol was the mainstay treatment for skeletal-related events prevention, Dmab provides an alternative formulation to IV infusions. This Time and Motion study was conducted in Italy to estimate time endpoints associated with Dmab SC and Zol IV use ...
A range of substrates is available for the cytochemical staining of peroxidase activity. The most utilized substrates are diaminobenzidine for brownish color, aminoethylcarbazole for reddish reactions and chloronaphthol to give a blue-black product. Thus, in double or triple staining experiments, antigens can be subsequently stained in the same tissue section ...
Doc. dr Nataša Prvulović Bunović je načelnica centra za Imidžing Instituta za onkologiju Vojvodine i docent na Medicinskom fakultetu u Novom Sadu.
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin ...
RESULTS: Forty-five (32.1%) patients were diagnosed with ATDH. No significant differences were reported in age and sex between patients with and without ATDH. Slow acetylators defined by NAT2 genotypes had a higher risk of hepatotoxicity than rapid acetylators (51.2% vs. 25.2%, P = 0.0026). Odds ratio (OR) analysis showed that slow acetylator status (OR 3.15, 95%CI 1.47-6.48) was the only independent risk factor for ATDH. Pyrazinamide co-administration induced hepatitis was also associated with NAT2 acetylator status. CYP2E1 c1/c1 homozygotes are prone to developing more severe hepatotoxicity than other c1/c2 and c2/c2 genotypes ...
Herein, a wide range of mono- and di-arylated products were efficiently prepared from C-N coupling of 2-halobenzothiazoles and primary aromatic amines, and representative compounds 3b and 4b were further confirmed by X-ray crystallography. It was noteworthy that the di-arylated products, denoted as di(benzothiazoly
ZANONI, Thalita Boldrin; LIZIER, Thiago M.; ASSIS, Marilda das Dores; ZANONI, Maria Valnice B.; OLIVEIRA, Danielle Palma de. CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III. Food and Chemical Toxicology, Kidlington, v. 57, p. 217-226, 2013. Disponível em: < http://dx.doi.org/10.1016/j.fct.2013.03.035 > DOI: 10.1016/j.fct.2013.03.035 ...
China Pigment Yellow 12 (Benzidine Yellow G-P), Find details about China Pigment Yellow 12, 10s Yellow 12 from Pigment Yellow 12 (Benzidine Yellow G-P) - Hangzhou Aibai Chemical Co., Ltd.
Tytuł projektu: Rozbudowa i przekształcenie bibliograficznej bazy danych AGRO w bazę bibliograficzno-abstraktową z wykorzystaniem oprogramowania YADDA. Nr umowy: POIG 02.03.02-00-031/09 (okres realizacji 2009-2013 ...
Benzidine, N,N,N,N-tetramethyl-; 4,4-Bis(N,N-dimethylamino)biphenyl; N,N,N,N-Tetramethyl-p,p-benzidine; [1,1-Biphenyl]-4,4-diamine,N,N,N,N-tetramethyl ...
Esistiamo grazie ebook site; del ingiuste. Io stessa, taught miliardi di ebook maß und, sono nata su -arrow- Occidente. Ho imparato a ebook maß und, a animazione, a part popolare nel people.
Antila E, Westermark T, On the etiopathogenesis and therapy of Down syndrome. Int. J. Dev. Biol. 33: 183-188, 1989 Medline. Baez S, Segura-Aguilar J, Widersten M, et al. Glutathione transferases catalyze the detoxification of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem. J. 324 (pt.1): 25-28, 1997 Medline. Bandmann O, Vaughen J, Holmans P, et al. Association of slow acetylator genotype for N-acetyltransferase 2 with familiar Parkinsons disease. Lancet 350: 1136-1139, 1997 Medline. Berry T. A selenium transport protein model of a sub-type of schizophrenia. Med. Hypothesis 43: 409-414, 1994 Medline. Brown K, Reid A, White T, et al. Vitamin E, lipids and lipid peroxidation products in tardive dyskinesia. Biol. Psychiatry 43: 863-867, 1998 Medline. Brugge KL, Nichols S, Delis D, et al. The role of alterations in free radical metabolism in mediating cognitive impairments in Down syndrome. EXS 62: ...
Golka and colleagues (1) critically refer to our observation that NAT2 genotype had no impact on bladder cancer risk (2). We were able to demonstrate in our case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) that occupational exposure to aromatic amines and polycyclic aromatic amines was associated with an increased bladder cancer risk. On the basis of the comprehensive genotyping of N-acetyltransferase 2 (NAT2), we observed that NAT2 slow acetylation was not itself associated with bladder cancer risk. Notably, our main effect of 1.02 [95% confidence interval (CI), 0.81-1.29] is clearly in line with the OR of 1.02 (95% CI, 0.87-1.19) for a tagging single-nucleotide polymorphism that the authors reported from a pooled analysis of their own studies (3).. We fully recognize that EPIC is a population-based cohort with a low prevalence of rare occupations known to entail a bladder cancer risk. We also mentioned in the article that the metabolism of ...
Mixed metallo-porphyrin cages were selected and amplified from dynamic combinatorial libraries (DCLs) by using appropriate templates. The cages are composed of two bisphosphine substituted zinc(II) porphyrins as ligand donors and two rhodium(III) or ruthenium(II) porphyrins as ligand acceptors, and are connected through metal-phosphorus coordination. Ru and Rh porphyrins that display a large structural diversity were employed. The templating was achieved by using 4,4-bpy, 3,3-dimethyl-4,4-bipyridine and benzo[lmn]-3,8-phenanthroline, and acts through zinc-nitrogen coordination. The absolute amount of amplification from the DCLs is strongly dependent on the combination of the Ru/Rh porphyrin and the template; cages with sterically demanding porphyrins can only form with smaller templates. In the case of tert-butyl-substituted TPP (TPP=tetraphenylporphyrin), cages are not formed at all. The formation of the cages is usually complete within 24 h at an ambient temperature; in the case of the cage ...
Hairdressing. Its an occupation associated with beauty but its practitioners have to put up with some ugly contacts. Im not talking about their clients but the products that they are obliged to use on the hair, in particular dyes and waving products. Some of these contain chemicals that have been linked to bladder cancer, namely aromatic amines...
A three component reaction with two different ketones and aromatic amines was firstly investigated. The difference in reactivity between ordinary ketones and ketone esters allowed for the production of 1,2-DHQs efficiently. The possible Skraup reaction with 2 equiv. of the same ketones was prohibited due to
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Elektronische Patientenakte Natürliche Sprache Strukturierte Daten If we look at how content is presented in the HER, so we have these two

*Sidestream smoke

... cadmium and 4-aminobiphenyl. Some of the other compounds found in sidestream smoke are: vinylchloride, hydrogen cyanide, ... 4-aminobiphenyl (4-ABP) is an integral component in tobacco smoke, as well as a risk factor for bladder cancer. Sidestream ... Exposure to sidestream smoke yields higher concentrations of these compounds as well as increased concentrations of ... 4-aminobiphenyl, and bladder cancer: two meta-analyses". Cancer Epidemiol. Biomarkers Prev. 18 (4): 1312-20. doi:10.1158/1055- ...

*XPhos

Both palladium and copper complexes of the compound exhibit high activity for the coupling of aryl halides and aryl tosylates ... It is especially efficient and general when employed as a (2-aminobiphenyl)-cyclometalated palladium mesylate precatalyst ...

*Phenanthridine

In the Pictet-Hubert reaction (1899) the compound is formed in a reaction of the 2-aminobiphenyl - formaldehyde adduct (an N- ... Phenanthridine is a nitrogen heterocyclic compound that is the basis of DNA-binding fluorescent dyes through intercalation. ...

*4-Aminobiphenyl

However, since it is a known human carcinogen, it has been largely replaced by less toxic compounds in other applications. " ... 4-Aminobiphenyl is an amine derivative of biphenyl. It is currently used to manufacture azo dyes. ...

*XPhos

Both palladium and copper complexes of the compound exhibit high activity for the coupling of aryl halides and aryl tosylates ... It is especially efficient and general when employed as a (2-aminobiphenyl)-cyclometalated palladium mesylate precatalyst ... XPhos is an organophosphorus compound derived from biphenyl. Its palladium complexes exhibit high activity for Buchwald-Hartwig ...

*List of MeSH codes (D02)

... biphenyl compounds MeSH D02.455.426.559.389.185.060 --- aminobiphenyl compounds MeSH D02.455.426.559.389.185.100 --- benzidines ... trialkyltin compounds MeSH D02.691.850.900.910 --- triethyltin compounds MeSH D02.691.850.900.950 --- trimethyltin compounds ... mustard compounds MeSH D02.455.526.728.468 --- mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455 ... bephenium compounds MeSH D02.092.877.096.333 --- bretylium compounds MeSH D02.092.877.096.333.150 --- bretylium tosylate MeSH ...

*Glucuronidation

One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver ... Generally, an increased rate of glucuronidation results in a loss of potency for the target drugs or compounds. Many drugs ... Al-Zoughool M., Talaska, G. (2006). "4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction ...

*Hair coloring

2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... In 2004 a known human carcinogen, 4-aminobiphenyl or 4-ABP, was found in some commercial hair dyes.[24] However, evidence is ... The primary intermediates are aromatic para compounds, such as 1,4-diaminobenzene or 4-aminophenol. The coupler compounds ( ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ...

*Tobacco smoke

Nicotine itself may serve as a template for further psychoactive compounds. Peak plasma levels of nicotine occur 2-10 min after ... 4-Aminobiphenyl)), and harmala alkaloids. The radioactive element polonium-210 is also known to occur in tobacco smoke. The ... with an even greater removal rate for other classes of compounds (e.g., phenols). Tobacco smoke may be grouped into a ...

*Diphenylamine

The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... The carcinogen 4-Aminobiphenyl can accompany diphenylamine as an impurity. Diphenylamine has low acute and short-term toxicity ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... pubchem.ncbi.nlm.nih.gov/compound/Diphenylamine#section= ...

*List of IARC Group 1 carcinogens

2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... tanning devices This evaluation applies to the group of compounds as a whole and not necessarily to all individual compounds ...

*Frédéric Y. Bois

Pery A., Bois F., 2009, Adaptation of PBPK model equations to study compound concentration stochasticity in cells and cancer ... The example of 4-aminobiphenyl, Risk Analysis, 15:205-213. Thouand G., Friant P., Bois F., Cartier A., Maul A., Block J.C., ... androgenic compounds, Epidemiology 17(6):S332-S333 Suppl. S. (non refereed) Desmots S., Lecomte A., Robidel F., Dupont O., Bois ...

T3DB: 4-AminobiphenylT3DB: 4-Aminobiphenyl

belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene ... 4-Aminobiphenyl exposure can be assayed by measuring the extent of adduct formation with hemoglobin. 4-Aminobiphenyl metabolism ... The metabolites of 4-aminobiphenyl may form adducts with DNA, inducing mutations. 4-Aminobiphenyl and its metabolites may also ... 4-Aminobiphenyl is an amine derivative of biphenyl. It is used to manufacture azo dyes. It is a known human carcinogen and so ...
more infohttp://www.t3db.ca/toxins/T3D0232

Known and Probable Human CarcinogensKnown and Probable Human Carcinogens

4-Aminobiphenyl. *Areca nut. *Aristolochic acid (and plants containing it). *Arsenic and inorganic arsenic compounds ...
more infohttp://www.cancer.org/cancer/cancer-causes/general-info/known-and-probable-human-carcinogens.html

Bladder cancer risk factors | Cancer Research UKBladder cancer risk factors | Cancer Research UK

Occupational exposures: Arsenic and inorganic arsenic compounds Exposure to arsenic or inorganic arsenic compounds is ... Van Hemelrijck MJ, Michaud DS, Connolly GN, Kabir Z. Secondhand smoking, 4-aminobiphenyl, and bladder cancer: two meta-analyses ... Working in production of auramine or magenta dyes, and exposure to 4-Aminobiphenyl, benzidine, 2-Naphthylamine, or ortho- ... Arsenic and arsenic compounds Available from http://monographs.iarc.fr/ENG/Monographs/vol100C/. Accessed April 2014. ...
more infohttp://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/bladder-cancer/risk-factors

M I ʤƾǪM I ʤƾǪ

Aromatic amines and related compounds 4-Aminobiphenyl* Benzidine* 3,3 -Dichlorobenzidine 3,3 -Dimethoxybenzidine 3,3 - ...
more infohttp://www.scu.edu.tw/microbio/proj/cai/safe/s1b2.htm

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

The aromatic compounds 4-aminobiphenyl (ABP) and 4,4-diaminobiphenyl (BZ) are known to have carcinogenic properties. LPO ... 0 (Aminobiphenyl Compounds); 0 (Carcinogens); 0 (DNA Adducts); 0 (Free Radicals); 16054949HJ (4-biphenylamine); EC 1.11.1.- ( ... The binding mode mimicked that of the natural substrate since these compounds did not disturb the water molecule that plays an ... Aromatic compounds are generally highly lipophilic and thus accumulate in highly fatty breast tissues. ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D13.444.308.135

TNO Repository search for: subject:Intraperitoneal drug administrationTNO Repository search for: subject:'Intraperitoneal drug administration'

Aminobiphenyl Compounds · Animal · Carcinoma in Situ · Cell Differentiation · Histocytochemistry · Hyperplasia · Male · ... The new compounds are substantially more lipophilic and much less toxic than the well-known antidote P2S. They reactivate ... Chemicals/CAS: atropine, 51-55-8, 55-48-1; soman, 96-64-0; Atropine, 51-55-8; Organophosphorus Compounds; Oximes; Soman, 96-64- ... Chemicals/CAS: cyproterone acetate, 427-51-0; testosterone propionate, 57-85-2; 2,3-dimethyl-4-aminobiphenyl, 13394-86-0; 9,10 ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject%3A%22Intraperitoneal%20drug%20administration%22

Haz-Map Category DetailsHaz-Map Category Details

Nitrogen Compounds. Synonyms. 1,1-Biphenyl)-4-amine; 4-Amino-1,1-biphenyl; 4-Aminobifenyl [Czech]; 4-Aminobiphenyl; 4- ... 1,1-Biphenyl)-4-amine; 4-Amino-1,1-biphenyl; 4-Aminobifenyl [Czech]; 4-Aminobiphenyl; 4-Aminodifenil [Spanish]; 4- ... p-Aminobiphenyl; p-Aminodiphenyl; p-Biphenylamine; p-Phenylaniline; p-Xenylamine; [ChemIDplus] ... p-Aminobiphenyl; p-Aminodiphenyl; p-Biphenylamine; p-Phenylaniline; p-Xenylamine; [ChemIDplus] ...
more infohttps://hazmap.nlm.nih.gov/category-details?id=279&table=copytblagents

3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyra... - Registration Dossier - ECHA3-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyra... - Registration Dossier - ECHA

Quinone type compounds OR Michael addition ,, Quinone type compounds ,, Quinone methides OR Non-covalent interaction OR Non- ... p-Aminobiphenyl Analogs OR Radical ,, Radical mechanism via ROS formation (indirect) ,, Quinones OR Radical ,, Radical ... beta-unsaturated carbonyl compounds OR AN2 ,, Nucleophilic addition to alpha, beta-unsaturated carbonyl compounds ,, alpha, ... Referential boundary: The target chemical should be classified as Anion OR Aromatic compound OR Carbonic acid derivative OR ...
more infohttps://echa.europa.eu/sv/registration-dossier/-/registered-dossier/17312/7/7/1

SEOM clinical guidelines to primary prevention of cancer (2018) | SpringerLinkSEOM clinical guidelines to primary prevention of cancer (2018) | SpringerLink

4-Aminobiphenyl. Bladder. Rubber manufacture. Arsenic and arsenic compounds*. Lung, skin. Glass, metals, pesticide ...
more infohttps://link.springer.com/article/10.1007%2Fs12094-018-02016-4

Organic nitrogen compounds - physical dataOrganic nitrogen compounds - physical data

4-Aminobiphenyl. 4-Phenylaniline, Xenylamine. 12. 11. 1. 169.22. 53. 348*. Amine. Alverine. N-ethyl-bis(3-phenylpropyl)-amine. ... Organic nitrogen compounds:. Amine: A compound or functional group that contain a basic nitrogen atom with a lone pair. It can ... Naming of organic compounds - Nomenclature rules for different groups of organic compounds and functional groups, together with ... Organic sulfur compounds - densities - Liquid density of different kinds of organic sulfur compounds with varying carbon number ...
more infohttps://www.engineeringtoolbox.com/amp/boiling-melting-organic-nitrogen-amine-pyrrole-pyridine-piperidine-quinoline-structure-density-molweight-d_1947.html

Anti-Viral Compounds - Leivers, Martin RobertAnti-Viral Compounds - Leivers, Martin Robert

Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I ... 2-[3′-(Cyclopropanecarbonyl-amino)-biphenyl-4-yl]-pyrrolidine-1-carboxylic acid benzyl ester (Compound 4009). A solution of ... 7. A compound of claim 1 wherein V is C and W is N. 8. A compound of claim 1 wherein Z is C(O). 9. A compound of claim 1 ... A compound of claim 11 wherein L1 is a bond. 13. A compound of claim 11 wherein L1 is C2 alkynylene 14. A compound of claim 11 ...
more infohttp://www.freepatentsonline.com/y2010/0055071.html

Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats...Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats...

The doses of the test compounds were selected based on previous studies (23). All rats were sacrificed at week 60 by ether ... In the current study, we investigated the effects of silymarin on 3,2′-dimethyl-4-aminobiphenyl (DMAB)-initiated prostate ... Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats ... Dietary Supplementation with Silymarin Inhibits 3,2′-Dimethyl-4-Aminobiphenyl-Induced Prostate Carcinogenesis in Male F344 Rats ...
more infohttp://clincancerres.aacrjournals.org/content/11/13/4962

Carcinogens everyday toxins, foods, houses, petroleum, Carcinogens in your houseCarcinogens everyday toxins, foods, houses, petroleum, Carcinogens in your house

4-aminobiphenyl. Arsenic and arsenic compounds. Asbestos. Manufacture of auramine. Azathioprine. Benzene. Benzidine. Beryllium ... Lead and lead compounds (inorganic). Magenta (containing CI Basic Red 9). Man-made mineral fibres (see glasswool, rockwool, ... Car paints contain some of the most toxic compounds.. Most people are breathing many carcinogens from the paints that they are ... Chromium compounds (hexavalent). Coal gasification. Coal tar pitches. Coal tars. Coke production. Cyclophosphamide. Cyclosporin ...
more infohttps://www.curezone.org/diseases/toxins/carcinogens.html

Compound Groups | PharosCompound Groups | Pharos

Salts of 4-aminobiphenyl. incomplete. This compound group is defined by the SMILES string [CH1]1=[CH1][CH1]=C([CH1]=[CH1]1)C2 ... Compound Groups. COMPOUND GROUP NAME. POPULATION STATUS DATE POPULATED. DESCRIPTION. PROFILE TYPE # MEMBERS. # HAZARDS. ... Toluene Diisocyanate (TDI) Compounds. incomplete. This compound group is defined by the SMILES string CC1=C(C=C(C=C1))N=C=O. ... Tetrabutyltin compounds. in progress. This compound group is defined by the SMILES string [CH3][CH2][CH2][CH2][Sn]([CH2][CH2][ ...
more infohttps://pharosproject.net/compound-groups?page=6

Patent US7556969 - Intensified neutral loss tags and use thereof in mass spectrometry - Google PatentsPatent US7556969 - Intensified neutral loss tags and use thereof in mass spectrometry - Google Patents

Detection of Amino-biphenyl using the Method of the Invention. Compound 13 was coupled to 4-aminobiphenyl analyte in the ... The mixture of compound 4 and NHS from the previous step was dissolved in 10 ml dry MeCN. compound 2 (590 mg, 1.9 mmol) was ... As seen, in this case, compound 4 was reacted with the NHS ester of 4-bromobutyric acid to give 11, and the latter compound was ... A mixture of compound 4 and NHS (1:1 mole ratio) was obtained, and was used for further reaction without separation. 1H NMR (CD ...
more infohttp://www.google.com/patents/US7556969?dq=5,545,531

CDC - NIOSH Publications and Products - Name of Publication (200#-###)CDC - NIOSH Publications and Products - Name of Publication (200#-###)

As in the case of the o-tolidine-based dyes, a residual amount of the parent compound may be present in the dye. (19) Lynn et ... Benzidine-based dyes may contain residual amounts of benzidine as well as other substances such as 4-aminobiphenyl, an OSHA- ... Cleaning compounds that contain strong reducing agents should not be used because benzidine or other harmful products could be ... The evidence is not definitive in all cases because the parent compound, o-tolidine, may sometimes be present in the dyes as a ...
more infohttps://www.cdc.gov/niosh/docs/81-106/default.html

Combi-BlocksCombi-Blocks

... nitro compounds, trifluoroborates, and other organics and fine chemicals. ... 4-Aminobiphenyl-3-carboxylic acid. Purity: 96%. [85096-04-4], MFCD03990480. SS-6475. 2-Aminobiphenyl-3-carboxylic acid, HCl. ... 2-Aminobiphenyl-3-carboxylic acid. Purity: 96%. [177171-15-2], MFCD03990478. CA-4866. 3-Aminobiphenyl-3-carboxylic acid. ... Amino-biphenyl-4-yl-acetic acid. Purity: 95%. [221101-61-7], MFCD02662412. QA-0599. 5-Amino-2-([1,1-biphenyl]-2-ylcarbonyl) ...
more infohttp://www.combi-blocks.com/blocks/CA3.htm

11 ingredients in U.S. foods so dangerous theyre banned in other countries | EmaxHealth11 ingredients in U.S. foods so dangerous they're banned in other countries | EmaxHealth

5 is banned in Norway and Austria because it contains the compounds benzidine and 4-aminobiphenyl.. a. "Six of the eleven ...
more infohttps://www.emaxhealth.com/11400/11-ingredients-us-foods-so-dangerous-theyre-banned-other-countries

Secondhand smoke - SourceWatchSecondhand smoke - SourceWatch

They are: 2-naphthylamine, 4-aminobiphenyl, benzene, vinyl chloride, ethylene oxide, arsenic, beryllium, nickel compounds, ... "Secondhand tobacco smoke contains over 4,000 chemical compounds. More than 60 of these are known or suspected to cause cancer ... Eleven compounds in tobacco smoke have been identified by the International Agency for Research on Cancer as Group 1 Human ...
more infohttps://www.sourcewatch.org/index.php/Secondhand_cigarette_smoke

4-Aminobiphenyl - Wikipedia4-Aminobiphenyl - Wikipedia

However, since it is a known human carcinogen, it has been largely replaced by less toxic compounds in other applications. " ... 4-Aminobiphenyl is an amine derivative of biphenyl. It is currently used to manufacture azo dyes. ...
more infohttps://en.wikipedia.org/wiki/4-Aminobiphenyl

609. Butylated hydroxytoluene (WHO Food Additives Series 21)609. Butylated hydroxytoluene (WHO Food Additives Series 21)

In N-nitroso compounds: Occurence, biological effects, and relevance to human cancer. ONeill, I.K., von Borstel, R.C., Miller ... However, BHT inhibited 3,2-dimethyl-4-aminobiphenyl- and benzidine-induced mutagenicity in the Salmonella test. In a recent ... Reddy, B.S., Hansen, D., Mathews, L., & Sharma, C. (1983a). Effect of micronutrients, antioxidants and related compounds on the ... 4-aminobiphenyl-induced mutagenicity in Salmonella typhimurium strains TA98 and TA100 in the presence of rat liver S-9 fraction ...
more infohttp://www.inchem.org/documents/jecfa/jecmono/v21je03.htm

Acyclic or Carbocyclic CompoundsAcyclic or Carbocyclic Compounds

2-HYDROXY-5-AMINO-BIPHENYL-DERIVATIVES AND OXIDATIVE HAIR COLOURING AGENTS CONTAINING SAID COMPOUNDS. The invention relates to ... DIPHENYL COMPOUNDS, FORMULATIONS AND USES THEREOF. For use in the inhibition of retinoic acid metabolism, diphenyl compounds of ... BIARYL COMPOUNDS. The present disclosure describes novel compounds and compositions which are particularly useful for treating ... New compounds of formula (I) are described: The compounds have potentially valuable pharmaceutical properties in the treatment ...
more infohttp://www.sumobrain.com/ICL-C07C225-p9.html
  • It is interesting that of the three isomers only 2-aminobiphenyl is non-planar, forming a dihedral angle of 40 degrees, and this may preclude it from acting as a substrate of the P-450I family of haemoproteins, which selectively catalyses the N-hydroxylation of many aromatic amines including 4-aminobiphenyl. (surrey.ac.uk)
  • The established GC-MS methods for the analysis of aromatic amines (o-Anisidine, o-Toluidine, 2,6-Dimethylaniline, 1-Aminonaphthalene, 2-Aminonaphthalene, and 4-Aminobiphenyl) involve complex sample preparation and analyzing the samples on a gas chromatograph with a single-quadrupole mass spectrometer. (coresta.org)
  • Primary aromatic amines (PAAs) are compounds of interest to a number of tobacco regulators and are routinely found in mainstream (MS) tobacco smoke. (coresta.org)
  • Six of the 93 compounds currently included on the United States Food and Drug Administration (FDA) established list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke (HPHCs) are primary aromatic amines. (coresta.org)
  • Ni, Cr) are also known to be carcinogenic.9,10 In addition, tobacco smoke contains volatile compounds (e.g., benzene) and radioelements (e.g., polo-nium-210) that may also play a role in its carcinogenicity.10 Cigarette smoke also contains free radicals capable of inducing oxidative DNA damage. (drdarrinlew.us)
  • In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids ( e.g. morphine and buprenorphine), coumarins, flavonoids ( e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds ( e.g. 4-nitrophenol). (aspetjournals.org)
  • With increasing demand for antioxidant supply in the food, honey had gained vitality since it is rich in phenolic compounds and other antioxidants like ascorbic acid, amino acids, and proteins. (hindawi.com)
  • Considerable differences in both composition and content of phenolic compounds have been found in different unifloral honeys [ 18 ]. (hindawi.com)
  • Twice as much nicotine is emitted in sidestream as in mainstream smoke, yet the carcinogen 4-aminobiphenyl is enriched about 30-fold in sidestream smoke. (epa.gov)
  • These include procedures for converting DNA adducts formed by 4-aminobiphenyl (92671), 4-aminofluorene (7083638), benzo(a)pyrene (50328), 4- (hydroxypyridyl)butanone, malondialdehyde (542789), 2- phosphoglycolate, and uracil (66228) into electrophores. (cdc.gov)
  • 4-Aminobiphenyl is an amine derivative of biphenyl. (wikipedia.org)
  • Glucuronide conjugation of xenobiotics containing a tertiary amine moiety represents a unique and important metabolic pathway for these compounds in humans. (aspetjournals.org)
  • We show that human UGT1A3, transiently expressed in human embryonic kidney 293 cells, also catalyzes the N -glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine. (aspetjournals.org)
  • We have investigated the induction of DNA-adducts in relation to mutagenesis in bladder and various non-target organs of transgenic Big Blue® mice treated weekly (i.p.) with a representative aromatic-amine compound, 4-aminobiphenyl (4-ABP), for six weeks, followed by a six-week recovery period. (aacrjournals.org)
  • Overexposure to biphenyl amine compounds, which are found in smoke and azo-dyes, is linked to the occurrence of bladder cancer. (semanticscholar.org)
  • However, the molecular mechanisms of biphenyl amine compound-induced bladder cancer are still unclear. (semanticscholar.org)
  • In humans, the metabolism of a number of tertiary amine-containing pharmacological agents to quaternary ammonium-linked glucuronides, catalyzed by UDP-glucuronosyltransferase (UGT), represents a unique and important metabolic pathway for these compounds. (aspetjournals.org)
  • Compounds of the above formula I, in which R.sup.16 or R.sup.20 is an acidic substituent or a group COOP.sup.1, and pharmaceutical salts thereof, are useful as pharmaceuticals. (justia.com)
  • As part of the method, Stephens stated that some dangerous compounds are completely absent in e-cigarette vapor. (vapetime.co.uk)
  • The method described here is a modification of a method used routinely in a high-sample throughput laboratory for PAA analysis in MS smoke and demonstrates the successful analysis of four PAAs in e-cigarette vapor: 1- and 2- aminonaphthalene and 3- and 4-aminobiphenyl. (coresta.org)
  • A significant number of the flavour chemicals were aldehydes, a compound class recognised as 'primary irritants' of mucosal tissue of the respiratory tract. (blogspot.com)
  • This compound group is populated by taking the more general compound group and subtracting the chemicals found in the relevent Annex. (pharosproject.net)
  • Chemicals are often used to extract these partial-food ingredients, and these compounds leave residues in the food. (huffpost.com)
  • The reactivity of the quinol imine derivatives follows the order: 4-hydroxyl more reactive than 4-methoxyl compounds and N-acetyl more reactive than N-benzoyl derivatives. (rti.org)
  • In the present studies we investigated the mutagenicity of these three compounds, their N-hydroxy derivatives and their nitrosoderivatives in the Ames test using the Salmonella typhimurium strains TA98 and TA100. (surrey.ac.uk)
  • The enzyme related to the tumorigenicity of these compounds was characterized by a highly specific capacity to form adducts from the acetyl and propionyl derivatives. (aacrjournals.org)
  • These findings suggest that the weak carcinogenicity of 3-aminobiphenyl may be attributed to the lack of genotoxicity of its N-hydroxyderivative, whereas in the case of 2-aminobiphenyl it may be due to the inability of the hepatic preparations to catalyse its N-hydroxylation, which is in agreement with published in vivo metabolic studies. (surrey.ac.uk)
  • Of the three isomers only 4-aminobiphenyl exhibited mutagenicity and only in the presence of an activation system. (surrey.ac.uk)
  • This compound group is defined by the SMILES string '[Rh]' and subsequently filtered to remove substances containing '[C]'. For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
  • MHLW has proposed to (I) designate azo compounds as harmful substances, (II) stipulate the scope of household products containing the azo compounds, and (III) determine the criteria and test methods. (intertek.com)
  • Approximately half of UC diagnoses are now attributed to cigarette smoke ( 4 ), which contains 4-aminobiphenyl and 2-napthylamine ( 3 ), but etiology among nonsmokers remains largely unknown. (aacrjournals.org)
  • Nitrate, which is introduced to the growing tobacco plant through the application of fertilizer, can be converted to ammonia, which, in turn, is converted to other nitrogenous organic compounds such as amino acids. (cdc.gov)
  • The reactivity of expressed human UGT1A3 toward hydroxylated and carboxylic acid-containing compounds was also examined. (aspetjournals.org)
  • These enzymes are localized primarily in the endoplasmic reticulum and participate in the metabolic elimination of many endogenous compounds and xenobiotics ( Clarke and Burchell, 1994 ). (aspetjournals.org)
  • Accordingly, the present invention provides a process for the preparation of a compound of formula (I) or a single enantiomer thereof, or a salt or a solvate thereof, wherein W is a chiral auxiliary or hydrogen and P?1¿ and P?2¿ are ea. (sumobrain.com)
  • The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. (sumobrain.com)
  • The novel compounds of the present invention are those of structural formula I: ##STR1## or a pharmaceutically acceptable salt, ester, or stereoisomer thereof, which are inhibitors of 5.alpha. (patentgenius.com)
  • This invention relates to novel azolo-fused pyrimidine compounds and their use as pharmaceuticals. (justia.com)
  • Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2′-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats. (aacrjournals.org)
  • New compounds of formula (I) are described: The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders. (sumobrain.com)
  • A further object is to provide active compounds which are potent ligands for nicotinic acetylcholine receptors (nAChR's). (google.com)
  • The chemistry of these compounds was dependent upon the pH and the substituents on the quinol imine derivative. (rti.org)
  • Compounds of formula I in which R.sup.16 or R.sup.20 is other than an acidic substituent or COOP.sup.1, that is, the remaining compounds of formula I, are intermediates in the synthesis of the pharmaceutically active compounds. (justia.com)