Amaranth Dye: A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)Carboxylic Ester Hydrolases: Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and a carboxylic acid anion.Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Caenorhabditis elegans Proteins: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.Caenorhabditis elegans: A species of nematode that is widely used in biological, biochemical, and genetic studies.Aedes: A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.Butterflies: Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.Allosteric Regulation: The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.EstersSterol Esterase: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Wound Healing: Restoration of integrity to traumatized tissue.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Procaine: A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).Anesthetics: Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.Anesthetics, Local: Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Salts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Anesthetics, Inhalation: Gases or volatile liquids that vary in the rate at which they induce anesthesia; potency; the degree of circulation, respiratory, or neuromuscular depression they produce; and analgesic effects. Inhalation anesthetics have advantages over intravenous agents in that the depth of anesthesia can be changed rapidly by altering the inhaled concentration. Because of their rapid elimination, any postoperative respiratory depression is of relatively short duration. (From AMA Drug Evaluations Annual, 1994, p173)Penicillin G Procaine: Semisynthetic antibiotic prepared by combining penicillin G with PROCAINE.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Lactoperoxidase: An enzyme derived from cow's milk. It catalyzes the radioiodination of tyrosine and its derivatives and of peptides containing tyrosine.PeroxidasesHair: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Horseradish Peroxidase: An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a histochemical tracer for light and electron microscopy. Its antigenicity has permitted its use as a combined antigen and marker in experimental immunology.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Benzyl Alcohols: Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Golf: A game whose object is to sink a ball into each of 9 or 18 successive holes on a golf course using as few strokes as possible.Subarachnoid Hemorrhage, Traumatic: Bleeding into the SUBARACHNOID SPACE due to CRANIOCEREBRAL TRAUMA. Minor hemorrhages may be asymptomatic; moderate to severe hemorrhages may be associated with INTRACRANIAL HYPERTENSION and VASOSPASM, INTRACRANIAL.Lasers: An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.Magnesium Compounds: Inorganic compounds that contain magnesium as an integral part of the molecule.Magnesium: A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Magnesium Sulfate: A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Lecture NotesAudiovisual Aids: Auditory and visual instructional materials.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.

Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. (1/194)

In five fasting, conscious dogs, we compared the prokinetic action of two selective 5-hydroxytryptamine-4 (5-HT4) receptor agonists with low affinity for 5-HT3 receptors ML10302 (2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate) and SR59768 (2-[(3S)-3-hydroxypiperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate) in the duodenum and jejunum, using cisapride as a reference compound. Heart rate and rate-corrected QT (QTc) also were monitored to assess whether or not the cardiac effects of cisapride are shared by other 5-HT4 receptor agonists. Both ML10302 and SR59768 dose-dependently stimulated spike activity in the duodenum with similar potencies (dose range, 3-300 nmol/kg i.v.; ED50 values: 24 and 23 nmol/kg i.v., respectively), mimicking the effect of cisapride (30-3000 nmol/kg i.v.). The maximal effect was achieved with the dose of 100 nmol/kg i.v. for both compounds. Similar findings were obtained in the jejunum. Atropine and GR125487 (1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl-methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate, selective 5-HT4 receptor antagonist), at doses having no effect per se, antagonized intestinal prokinesia by maximal doses of ML10302 and SR59768. Neither ML10302 nor SR59768 had any effect on heart rate or QTc at any of the doses tested, whereas cisapride, at the highest dose (3000 nmol/kg), induced tachycardia and lengthened the QTC (p <.01). In conclusion, ML10302 and SR59768 share with cisapride a similar prokinetic action in the canine duodenum and jejunum in vivo. This effect is mediated by pathways involving activation of 5-HT4 and muscarinic receptors. Unlike cisapride, which induces tachycardia and prolongs the QTc by a mechanism probably unrelated to 5-HT4 receptor activation, ML10302 and SR59768 are devoid of cardiac effects in this model.  (+info)

Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. (2/194)

Mitomycin C (MC) is an antitumor antibiotic derived biosynthetically from 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, and carbamoyl phosphate. A gene (mitA) involved in synthesis of AHBA has been identified and found to be linked to the MC resistance locus, mrd, in Streptomyces lavendulae. Nucleotide sequence analysis showed that mitA encodes a 388-amino-acid protein that has 71% identity (80% similarity) with the rifamycin AHBA synthase from Amycolatopsis mediterranei, as well as with two additional AHBA synthases from related ansamycin antibiotic-producing microorganisms. Gene disruption and site-directed mutagenesis of the S. lavendulae chromosomal copy of mitA completely blocked the production of MC. The function of mitA was confirmed by complementation of an S. lavendulae strain containing a K191A mutation in MitA with AHBA. A second gene (mitB) encoding a 272-amino-acid protein (related to a group of glycosyltransferases) was identified immediately downstream of mitA that upon disruption resulted in abrogation of MC synthesis. This work has localized a cluster of key genes that mediate assembly of the unique mitosane class of natural products.  (+info)

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. (3/194)

BACKGROUND: The mitomycins are natural products that contain a variety of functional groups, including aminobenzoquinone- and aziridine-ring systems. Mitomycin C (MC) was the first recognized bioreductive alkylating agent, and has been widely used clinically for antitumor therapy. Precursor-feeding studies showed that MC is derived from 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate. A genetically linked AHBA biosynthetic gene and MC resistance genes were identified previously in the MC producer Streptomyces lavendulae NRRL 2564. We set out to identify other genes involved in MC biosynthesis. RESULTS: A cluster of 47 genes spanning 55 kilobases of S. lavendulae DNA governs MC biosynthesis. Fourteen of 22 disruption mutants did not express or overexpressed MC. Seven gene products probably assemble the AHBA intermediate through a variant of the shikimate pathway. The gene encoding the first presumed enzyme in AHBA biosynthesis is not, however, linked within the MC cluster. Candidate genes for mitosane nucleus formation and functionalization were identified. A putative MC translocase was identified that comprises a novel drug-binding and export system, which confers cellular self-protection on S. lavendulae. Two regulatory genes were also identified. CONCLUSIONS: The overall architecture of the MC biosynthetic gene cluster in S. lavendulae has been determined. Targeted manipulation of a putative MC pathway regulator led to a substantial increase in drug production. The cloned genes should help elucidate the molecular basis for creation of the mitosane ring system, as well efforts to engineer the biosynthesis of novel natural products.  (+info)

Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress. (4/194)

OBJECTIVE: Inhibitors of poly (ADP-ribose) synthetase (PARS) activity reduce the infarct size caused by regional myocardial ischaemia and reperfusion in the rabbit and rat in vivo. The mechanism of action of these inhibitors is unclear. Here we investigate the effects of the PARS inhibitor 3-aminobenzamide (3-AB) on infarct size caused by ischaemia and reperfusion of the isolated, perfused heart of the rat. We also investigate the role of PARS in the hydrogen peroxide-mediated cell injury/necrosis in rat cardiac myoblasts. METHODS: Rat isolated hearts perfused at constant pressure (80 mmHg) were subjected to 35 min of regional ischaemia and 2 h of reperfusion. Infarct size was determined at the end of the experiment using nitro-blue tetrazolium. 3-AB (300 microM) or 3-aminobenzoic acid (3-ABA, 300 microM) were infused during the reperfusion period. Rat cardiac myoblasts (H9c2 cells) were preincubated with the PARS inhibitors, 3-AB. nicotinamide (Nic) or 1,5-dihydroxyisoquinoline (ISO) or the inactive analogues 3-ABA or nicotinic acid (NicA) prior to exposure with hydrogen peroxide (1 mM). Cell injury was assessed by measuring mitochondrial respiration and cell necrosis by measuring the release of LDH. PARS activity was determined by measuring the incorporation of NAD into nuclear proteins. RESULTS: Regional ischaemia and reperfusion of the isolated rat heart resulted in an infarct size of 54% which was reduced by 3-AB, but not by 3-ABA. Exposure of rat cardiac myoblasts to hydrogen peroxide caused an increase in PARS activity and cell injury/necrosis which was attenuated by pretreatment with the PARS inhibitors. CONCLUSION: Inhibition of the activity of PARS attenuates the cell death associated with oxidant stress in rat cardiac myoblasts and heart.  (+info)

Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. (5/194)

Although membrane tubules can be found extending from, and associated with, the Golgi complex of eukaryotic cells, their physiological function has remained unclear. To gain insight into the biological significance of membrane tubules, we have developed methods for selectively preventing their formation. We show here that a broad range of phospholipase A2 (PLA2) antagonists not only arrest membrane tubule-mediated events that occur late in the assembly of the Golgi complex but also perturb its normal steady-state tubulovesicular architecture by inducing a reversible fragmentation into separate "mini-stacks." In addition, we show that these same compounds prevent the formation of membrane tubules from Golgi stacks in an in vitro reconstitution system. This in vitro assay was further used to demonstrate that the relevant PLA2 activity originates from the cytoplasm. Taken together, these results demonstrate that Golgi membrane tubules, sensitive to potent and selective PLA2 antagonists, mediate both late events in the reassembly of the Golgi complex and the dynamic maintenance of its steady-state architecture. In addition, they implicate a role for cytoplasmic PLA2 enzymes in mediating these membrane trafficking events.  (+info)

Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes. (6/194)

OBJECTIVE: A dog atrial ultra-rapid delayed rectifier current (I(Kur. d)) is involved in canine atrial repolarization and shares similarities with the human atrial ultra-rapid delayed rectifier (I(Kur)). Almost no information is available about the actions of antiarrhythmic drugs on I(Kur.d). This study evaluated effects of ambasilide, quinidine, flecainide and verapamil on I(Kur.d) in isolated canine atrial myocytes. METHODS: Standard whole-cell patch clamp techniques were used to study the effects of multiple concentrations of each drug. RESULTS: All drugs produced reversible concentration-, voltage- and time-dependent I(Kur.d) inhibition. Significant effects of quinidine, flecainide and ambasilide were noted at atrial-effective antiarrhythmic concentrations in the dog. Upon the onset of a depolarizing pulse, block developed exponentially in relation to time, with the blocking rate-constant increasing with drug concentration, consistent with open-channel blockade and permitting the calculation of forward and reverse rate-constants. For all drugs, the 50% blocking concentration (EC(50)) showed significant voltage-dependence, decreasing at more positive potentials. The magnitude of voltage-dependent block was directly related to the degree of drug-induced shift in the voltage dependence of activation (r=0.97), pointing to open-channel block as a mechanism for voltage-dependent action. An additional component of voltage-dependence suggested that blocking sites were subjected to 17-21% of the transmembrane voltage field. CONCLUSIONS: Ambasilide, quinidine, flecainide and verapamil inhibit I(Kur.d), with preferential action on the open state. I(Kur.d) inhibition may play a role in antiarrhythmic effects in canine atrial arrhythmia models. Comparisons between the effects of these drugs on I(Kur.d) and previously studied effects on I(Kur) suggest potential opportunities for investigating the molecular structural determinants of drug-blocking action on atrial-specific ultrarapid delayed rectifiers.  (+info)

Pharmacological properties of 5-Hydroxytryptamine(4) receptor antagonists on constitutively active wild-type and mutated receptors. (7/194)

We studied the pharmacological properties of twenty-four 5-hydroxytryptamine (5-HT)(4) receptor ligands known to act as antagonists on 5-HT(4) receptors positively coupled to adenylyl cyclase endogenously expressed in mouse colliculi neurons. In COS-7 cells expressing human or mouse 5-HT(4(a)) receptors (100-8000 fmol/mg of protein), we found neutral antagonists, partial agonists, and inverse agonists. The majority of neutral antagonists belong to the benzodioxanyl ketone class, whereas partial agonists belong to different chemical classes. We found only two inverse agonists, GR 125487 and SB 207266, which are both indoles. Analysis of pharmacological characteristics of the constitutively active wild-type and constitutively active mutated receptors revealed that 1) the ratio between the efficiencies of the full agonist 5-HT and the partial agonist RS 23597 was invariable when the receptor density increased, but was dependent on receptor structure; 2) similarly, the efficacy of the inverse agonist SB 207266 was not dependent on receptor density but was dependent on receptor structure; 3) when the receptor concentration increased, the EC(50) values of the full agonist 5-HT were not modified and the increase in basal constitutive activity, as well as its stimulation by 5-HT, followed a parallel evolution; and 4) the stimulation of basal constitutive activity by 5-HT was not modified by the overexpression of Galphas. All these results indicate that in COS-7 cells, the coupling of the 5-HT(4) receptor to adenylyl cyclase was linear with no indication of spare receptors even at high receptor density (8 pmol/mg). These results are also in accordance with a precoupling between the activated receptor (f(R*)) and adenylyl cyclase. Such observations allowed us to use the two-state model to calculate the constant J, i.e., the equilibrium allosteric constant denoting the ratio of the receptor in the inactive versus active state (J = [R]/[R*]). We found that J was a receptor structural characteristic, independent of receptor density.  (+info)

AIT-082, a cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism. (8/194)

A fundamental feature of any drug designed to treat a disease of the central nervous system is the ability to cross the blood-brain barrier. Passage across the blood-brain barrier of AIT-082, a cognitive enhancer, was investigated in mice. [(14)C]AIT-082 crossed the blood-brain barrier in young male Swiss-Webster mice with a mean influx constant (K(i)) of 0.6 +/- 0.2 microl g(-1) min(-1). Furthermore, [(14)C]AIT-082 was transported into brain of both young and old male C57BL/6 mice with a K(i) of 0.35 +/- 0.06 and 0.33 +/- 0.02 microl g(-1) min(-1), respectively. There was no significant effect of age or strain on the movement of [(14)C]AIT-082 across the blood-brain barrier in mice. When 110- or 650-fold excess unlabeled AIT-082 was included in the injection solution, the K(i) was not significantly changed in either Swiss-Webster or C57BL/6 mice. This indicated that [(14)C]AIT-082 crossed the blood-brain barrier by a nonsaturable mechanism. The passage of AIT-082 into brain extracellular fluid was confirmed with capillary depletion and microdialysis. The efflux of [(14)C]AIT-082 from brain also was examined. After i.c.v. injection, [(14)C]AIT-082 levels in brain decreased over time with a t(1/2) of 20.0 +/- 1.0 min. Excess unlabeled AIT-082 (600-fold) increased the t(1/2) to 35.5 +/- 3.6 min. Together, these data indicate that AIT-082 moves into brain via a nonsaturable mechanism and is actively transported out of brain.  (+info)

*Aminobenzoate decarboxylase

McCullough WG, Piligian JT, Daniel IJ (1957). "Enzymatic decarboxylation of three aminobenzoates". J. Am. Chem. Soc. 79 (3): ...

*Farinamycin

Walsh CT, Haynes SW, Ames BD (2012). "Aminobenzoates as building blocks for natural product assembly lines". Nat. Prod. Rep. 29 ...

*Antrafenine

Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. ...
Background - There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains. Herein, we have examined the susceptibility of mycobacteria to the natural product platensimycin.. Methods and Findings - We have demonstrated that platensimycin has bacteriostatic activity against the fast growing Mycobacterium smegmatis (MIC = 14 µg/ml) and against Mycobacterium tuberculosis (MIC = 12 µg/ml). Growth in the presence of paltensimycin specifically inhibited the biosynthesis of mycolic acids suggesting that the antibiotic targeted the components of the mycolate biosynthesis complex. Given the inhibitory activity of platensimycin against β-ketoacyl-ACP synthases from Staphylococcus aureus, M. tuberculosis KasA, KasB or FabH were overexpressed in M. smegmatis to establish whether these mycobacterial KAS enzymes were targets of ...
33149-157. Although smear-positive cases are the most infectious, neglecting smear-negative disease (approximately half of cases overall) increases the morbidity and mortality of the disease in those pa- tients and does not account for the significant burden of Buy Tricaine MPS Syp attributable to these smear-negative cases (17 of all transmission in one study using molecular epidemiology techniques) 6. This means that the chemical na- ture of this internal signal system is both known and controllable, Y.
This past month, scientists at Mercks Rahway, New Jersey, research labs announced their discovery of platensimycin, a chemical that kills Staphylococcus aureus via a new biological target-the bacterial enzyme FabF, crucial in the assembly of the fatty acids that make up a gram-positive bacteriums cell wall.. Its been four decades since medicine gained a new class of antimicrobial drug, four decades in which standard drugs have driven the rise of once-rare bacterial genes for chopping up, pumping out or otherwise neutralizing them. These genes can now be found in abundance in the bacteria that inhabit not only our hospitals but also our bodies. For good reason, hope for treating drug-resistant infectious diseases has long resided in blind-siding the bugs with something entirely new, something against which no bacterial resistance mechanism has yet been found.. Thats what Merck scientist Jun Wang and colleagues say they have found in platensimycin, a small molecule produced by Streptomyces ...
Animals. Zebrafish (Danio rerio) WIK were maintained under a 14 hours light/10 hours dark cycle at 28.5°C. WT C57BL/6 male mice (age, 8 weeks) were purchased from the Jackson Laboratory and maintained on a 12-hour light-dark cycle and were inspected daily.. Expansion of ZIC mutant collection and DOX modifier screen. We previously developed an expression-based strategy to enrich ZIC mutants from GBT lines (15). In the present study, we expanded the ZIC mutant collection by identifying GBT lines with visible mRFP signal in the heart during either embryonic or adult stages. To examine cardiac expression during embryonic stages, we anesthetized embryos 2-5 days postfertilization (dpf) using 0.16 mg/ml tricaine (Argent Chemical Laboratories) to arrest the heartbeat. mRFP signal was observed using a Zeiss microscope. To examine cardiac expression at adult stages, fish 3-18 months of age were anesthetized with tricaine (Argent Chemical Laboratories). Hearts were dissected and observed under a Zeiss ...
Potassium aminobenzoate is a form of Vitamin B, which supports many important body functions. Potassium aminobenzoate works by softening the skin or tissues and raising oxygen levels in tissues of the body. Potassium aminobenzoate is used to treat conditions that cause skin or tissues to harden, including scleroderma...
Sodium 4-aminobenzoate | C7H6NNaO2 | CID 517441 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
You are viewing an interactive 3D depiction of the molecule [(2R,3S,4R,5R)-2-(6-aminopurine-1,3,7-triium-9-yl)-4-hydroxy-5-(phosphonooxymethyl)tetrahydrofuran-3-yl] 2-aminobenzoate (C17H19N6O8P) from the PQR.
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[118 Pages Report] Check for Discount on Global P-Aminobenzoic Acid Market Research Report 2016 report by QYResearch Group. Notes: Production, means the output of P-Aminobenzoic Acid Revenue,...
4-aminobenzoic acid, 4-aminobenzoic acid hydrazide, ABAH, Aktipol , aminobenzoate potassium, BAB, BT-PABA, butyl aminobenzoate, cyclic amino acid, disulphate ester of ursodeoxycholyl-p-aminobenzoic acid, ester oxybenzone, ethyl p-aminobenzoate, ethyl-4-N,N-dimethylaminobenzoate, ethyl dihydroxypropylaminobenzoate, glyceryl paraaminobenzoate, isobutyl p-aminobenzoate, KPAB, K-para-aminobenzoate, monoglyceryl para-aminobenzoate, n-benzyol-l-tyrosyl-p-aminobenzoic acid, NBT-PABA, n-butyl-p-aminobenzoate, n-diethyl-methyl-ammonium ethyl bromide-p-[2(n-octyloxy)-benzoyl-]aminobenzoate, N,N-dimethyl-2-ethylhexyl para-aminobenzoate, octyl dimethyl PABA, Pabafil , PABA-UDCA, padimate O, PAMBA, p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para-aminobenzoate potassium, para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA, Photoplex, POTABA , potassium ...
4-aminobenzoic acid, 4-aminobenzoic acid hydrazide, ABAH, Aktipol , aminobenzoate potassium, BAB, BT-PABA, butyl aminobenzoate, cyclic amino acid, disulphate ester of ursodeoxycholyl-p-aminobenzoic acid, ester oxybenzone, ethyl p-aminobenzoate, ethyl-4-N,N-dimethylaminobenzoate, ethyl dihydroxypropylaminobenzoate, glyceryl paraaminobenzoate, isobutyl p-aminobenzoate, KPAB, K-para-aminobenzoate, monoglyceryl para-aminobenzoate, n-benzyol-l-tyrosyl-p-aminobenzoic acid, NBT-PABA, n-butyl-p-aminobenzoate, n-diethyl-methyl-ammonium ethyl bromide-p-[2(n-octyloxy)-benzoyl-]aminobenzoate, N,N-dimethyl-2-ethylhexyl para-aminobenzoate, octyl dimethyl PABA, Pabafil , PABA-UDCA, padimate O, PAMBA, p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para-aminobenzoate potassium, para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA, Photoplex, POTABA , potassium ...
4-aminobenzoic acid, 4-aminobenzoic acid hydrazide, ABAH, Aktipol , aminobenzoate potassium, BAB, BT-PABA, butyl aminobenzoate, cyclic amino acid, disulphate ester of ursodeoxycholyl-p-aminobenzoic acid, ester oxybenzone, ethyl p-aminobenzoate, ethyl-4-N,N-dimethylaminobenzoate, ethyl dihydroxypropylaminobenzoate, glyceryl paraaminobenzoate, isobutyl p-aminobenzoate, KPAB, K-para-aminobenzoate, monoglyceryl para-aminobenzoate, n-benzyol-l-tyrosyl-p-aminobenzoic acid, NBT-PABA, n-butyl-p-aminobenzoate, n-diethyl-methyl-ammonium ethyl bromide-p-[2(n-octyloxy)-benzoyl-]aminobenzoate, N,N-dimethyl-2-ethylhexyl para-aminobenzoate, octyl dimethyl PABA, Pabafil , PABA-UDCA, padimate O, PAMBA, p-acetamidobenzoic acid, p-acetamidohippuric acid, p-aminobenzoic acid, p-aminohippuric acid, para-aminobenzoate, para-aminobenzoate potassium, para aminobenzoic acid, paraaminobenzoic acid, para-aminobenzoic acid, para-aminomethylbenzoic acid, PEG-25 PABAs, Peptide-PABA, Photoplex, POTABA , potassium ...
Prostate-specific Membrane Antigen Antibody-Drug Conjugate (PSMA ADC) 1301EXT is an open-label, nonrandomized, phase 1 extension study of PSMA ADC administered IV in subjects with progressive CMPC that has progressed after prior taxane therapy. Subjects who have participated in PSMA ADC 1301 and who, in the opinion of the PI, are likely to benefit from continued treatment with PSMA ADC will be enrolled in PSMA ADC 1301EXT ...
This study deals with the hourly determination of metabolic differences during growth with sulphathiazole (ST) between the ST-sensitive and ST-resistant strains of Escherichia coli and Staphylococcus aureus for the timing of the onset of resistance mechanism. The amounts of the extracellularly accumulated p-aminobenzoic acid (PAB), folic acid (FA) and citrovorum factor (CF) in the culture fluids and the growth rates are determined. As described in the preceding paper, the sequence of metabolic events with these strains is of the same pattern. The PAB curve in the resistant cell system with ST rises perpendicularly to a peak and then declines sharply followed by the rise of the growth curve. In contrast, in the sensitive cell system with ST, the PAB curve, after reaching a peak, forms a longlasting plateau or a dome-like plateau. During these plateau periods growth is absent. The decline in the plateau is followed by growth. In both the sensitive and resistant strains (E. coli), the ...
11278540] Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. (J Biol Chem. , 2001 ...
11278540] Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. (J Biol Chem. , 2001 ...
Molecular container mops up tricaine to reverse anaesthesia in fish A lack of clinically available antidotes for general anesthesia has prompted a team of researchers in China and Canada to explore the potential of a macrocyclic compound for halting anesthesia in zebrafish. ...
3-(2-Aminoethyl)indol-5-ol p-aminobenzoate dihydrochloride | C17H19Cl2N3O2 | CID 29683 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
[65 Pages Report] Check for Discount on Ethyl 2-Aminobenzoate Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.. ...
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Experiments at the University of Florida Tropical Aquaculture Laboratory were run to test various shipping chemical additives for their effects on appearance and behavior of fish post shipping. The chemicals tested were tricaine methanesulfonate (MS-222), salt (3 ppt NaCl), methylene blue, acriflavine neutral, quinaldine, eugenol, an experimental commercial product in the form of a feed, and a water additive.. The commercial product contained arachidonic acid (ArA), a fungus extract from Mortierella sp., claimed by the manufacturer to be used to regulate immune systems; and an ethanol extract from the genus Opuntia, a cactus species, claimed by the manufacturer to be used to stimulate the production of heat shock proteins (HSPs) that work to counteract stress responses.. Tricaine methanesulfonate is approved for use in finfish as a sedative and anesthetic. Quinaldine and eugenol are not approved for use in aquaculture. A description of approval for the other chemicals tested in this experiment ...
The present disclosure provides compositions and methods for the biosynthetic production of acetaminophen, p-aminophenol, and p-aminobenzoic acid and the purification of biologically derived acetaminophen.
Chengdu Biopurify offers 4-Hydroxybenzoic acid [99-96-7] - Product name: 4-Hydroxybenzoic acid Synonym name:... Customizes high quality Phytochemicals, from grams to kilograms, GMP is available. Offers compound library and high quality Herb Extracts.
The report generally describes 3,5-dimethoxy-4-hydroxybenzoic acid, examines its uses, production methods, patents. 3,5-Dimethoxy-4-hydroxybenzoic acid
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2-Chloro-4-hydroxybenzoic acid 56363-84-9 NMR spectrum, 2-Chloro-4-hydroxybenzoic acid H-NMR spectral analysis, 2-Chloro-4-hydroxybenzoic acid C-NMR spectral analysis ect.
The sulfonamides are weakly acidic compounds that have a common chemical nucleus resembling p-aminobenzoic acid (PABA). Members of this group differ mainly in their pharmacokinetic properties and clinical uses. Pharmacokinetic features include modest tissue penetration, hepatic metabolism, and excretion of both intact drug and acetylated metabolites in the urine. Solubility may be decreased in acidic urine, resulting in precipitation of the drug or its metabolites. Because of the solubility limitation, a combination of 3 separate sulfonamides ...
1. Methods are described for the estimation of procaine and its transformation products in biological fluids and tissues in vivo.. 2. The first step in the metabolism of procaine after its intravenous administration to man was shown to be hydrolysis to diethylaminoethanol and p-aminobenzoic acid. The hydrolysis takes place with unusual rapidity. Diethylaminoethanol is further metabolized in large part, but the nature of its transformation is not known.. 3. The hydrolysis of procaine occurs mainly in the plasma.. ...
Hi all, Does anyone know of an anaesthetic that can be used in an electrophysiology paradigm in fish? We are interested in measuring nerve conductance velocity. Tricaine/Mesab/MS-222 blocks action potentials and therefore is useless for us. Has anyone used curare to block movements? What about analgesics? Thanks, Christian -- *********************************** Christian Brösamle Department of Biochemistry Ludwig-Maximilians-Universität München Schillerstrasse 44 80336 München Germany tel: +49 89 2180 75-451 fax: +49 89 2180 75-415 ...
Antisoma Research Ltd (Antisoma) was developing a series of telomerase inhibitors for the treatment of cancer. Telomeres are the protective regions found at the
|strong||em|Result|/em||/strong|: Energizes & alkalinizes the body, promoting vitality you can feel. |strong||em|Benefit|/em||/strong|: 40 essent ...
Synonyms for Aminobenzoic acids in Free Thesaurus. Antonyms for Aminobenzoic acids. 1 word related to aminobenzoic acid: acid. What are synonyms for Aminobenzoic acids?
Definition of pancreatic function tests in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is pancreatic function tests? Meaning of pancreatic function tests as a legal term. What does pancreatic function tests mean in law?
The report generally describes 4-aminobenzoic acid potassium salt, examines its uses, production methods, patents. 4-Aminobenzoic acid potassium salt
Changzhou Sunlight Pharmaceutical Co., Ltd. was founded in 1990 with two plants: one is in Changzhou city which covers an area of 369, 580㎡; the other one is in Yancheng city which covers an area of 166,668㎡. We mainly produce APIs, Pharmaceutical intermediates, Fine chemicals, Specialty chemicals, and High performance monomers. We provide professional custom manufacturing service from lab to pilot scale for each customer. Our core technology advantages include high pressure catalytic hydrogenation and cryogenic reaction (≤-78℃), etc.. 4-Aminobenzoic acid (PABA), Ethyl P-Aminobenzoate(Benzocaine), Butyl 4-Aminobenzoate(Butamben), 3-Aminobenzoic acid, 4,4-Diaminobenzanilide, 4-Acetamidobenzoic acid, 4-(Acetylamino)benzoic acid-1-(dimethylamino)propan-2-ol(1:1), 3-(Trifluoromethyl)phenol, 4-Hydroxyindole (4-Indolol), 4-Phenoxybenzoic acid, N-BOC-3-hydroxypiperidine, UV-1. ...
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
The mechanism by which gentamicin augments the uptake of p-aminohippurate (PAH) by rat renal cortical slices was investigated. In all experiments, gentamicin was administered as gentamicin sulfate at 100 mg/kg b.wt. per day for 2 days; control rats were injected with saline. The effect of gentamicin on the metabolism of PAH to p-aminobenzoic acid (PABA), acetyl-PABA and acetyl-PAH was studied by high performance liquid chromatography. No metabolites of PAH were detected in renal slices of gentamicin-injected or control rats incubated in medium containing PAH. Efflux of 14C-PAH was measured after incubating renal cortical slices for 2 hours in medium containing 8 X 10(-5) M 14C-PAH. The efflux rate constant was 0.080 +/- 0.003/min in control slices and 0.059 +/- 0.003/min in gentamicin slices, P less than .001. No significant difference in the diffusible pool of PAH was found between the two groups which supports an argument against increased tissue-binding of PAH as the explanation for the ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The zinc-finger transcription factor Insulinoma-associated 1 (Insm1, previously IA-1) is expressed in the developing anxious and neuroendocrine systems, and is required for cell type specific differentiation. maintained in accordance with established protocols for zebrafish husbandry (Westerfield, 1995). Larvae and Embryos had been housed at 28C, on the 14 h light:10 h dark routine. Fish had been anaesthetized with Ethyl 3-aminobenzoate methanesulfonate sodium (MS-222, Tricaine, Sigma-Aldrich, St. Louis, MO). Embryos had been staged as previously referred to (Kimmel et al., 1995). Crazy type strains included the Ekwill stress (Ekwill Fish Plantation, Gibsonton, FL), the Stomach strain extracted from the Zebrafish International Analysis Middle (ZIRC, Eugene, OR) and hybrids made by crossing the Ekwill and Stomach strains. The Tg MK-0812 (XRho: distance43-mCFP) q13 transgenic range, called XOPS-mCFP hereafter, continues to be previously referred to (Morris et al., 2011; Morris et al., 2008a). This ...
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
GH3 GerovitalDietary Supplement 60 CapletsDirections: Take Two Tablets Daily, or as Directedby Your Health Care Professional.Two Tablets Contain:Calories 0Vitamin B-6 5mg 250% Folic Acid 400mcg 100% Vitamin B-12 20mcg 333% Pantothenic Acid 50mg 500% p-Aminobenzoic Acid 400mg 2-Dimethlyaminoethanol Bitartrate 200mgGingko Biloba (Leaf) Extract 50mgAdaptogen Complex Proprietary Blend 300mg ProteusteroneSchizandra (berry) Panex Ginseng (root)Gotu Kola (leaves)Dont Just Live Longer - LiveYounger More than 40 years of testing proves Gerovital GH3 tobe the most trusted and most effective anti-aging therapy available. Used on aregular basis, Gerovital GH3 may...Enhance memory. Re-invigorate sexual function. Improve mental clarity. Increase alertness. Help regulate moods. Fight fatigue, anxiety and insomnia. Reduce risk of heart disease. Reduce risk of stroke. Reduce free radicals which cause cancer. Reduce the effects of stress and so much more.One of the first anti-aging therapies, Gerovital GH3reduces free
Aminohippurate (p-aminohippuric acid, PAH, PAHA) is the glycine amide of p-aminobenzoic acid. It is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of aminohippurate is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate. Aminohippurate is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete aminohippurate. Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be ...
Pharmacology Review Sheets: Antibiotics, p.1Sulfonamides. Common Properties- Structure: Substitutions put ~ ring. ↓. activity- P-aminobenzoic stinging (PABA) analog- Competitively inhibits pteroic sharp synthetase- Absolutely specifically toic- Bacteriostatic- !eeds time to ta"e issue (effects aren#t immediate)- $esistance. •. ↑. PABA reduction by evaporation-. ↓. upta"e of sulfonamides-. ↓. affinity of pteroic acid synthetase for enzyme- Spectrum: %&s nocardiosis chlamydial infections- istribution. •. *ets into C!S (flat +ithout inflammation)- oesn#t pass prostate +ell because it#s acidic- ,etabolism and cretion- Parent or acetylated derivative ecreted in the urine- Adverse movables- rug Allergy: Stevens-.ohnson#s syndrome (necrotizing forfeiture of s"in). •. Crystaluria (esp/ +ith older sulfonamides)- 0ernicterus: yello+ing of fingernails and sclera potential neurological symptoms-. D!"# give to women in $. rd. three months, nursing mothers, ...
Ask questions and get answers about Potassium Aminobenzoate. Our support group helps people share their own experience. 9 news articles.
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Salicylic acid (sal-i-SILL-ik AS-id) is also known as 2-hydroxybenzoic acid. It melts at 159º C. You can dissolve it in ethanol and ether. It i...
oxybenzoic definition: hydroxybenzoic; Hydroxybenzoic; pertaining to, or designating, anybody of a number of hydroxyl types of benzonic acid, which the most common is salicylic acid.; Noting benzoic acid…
This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
The report reviews the competitive landscape and pipeline of antibody-drug conjugates and analyzes R&D stage, targets and drug payloads of ADCs as well as company portfolios.
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Bacteria PabC protein: closely related to D-alanine aminotransferase; involved in p-aminobenzoate synthesis; amino acid sequence given in first source
Looking for SIGMA-ALDRICH Benzocaine,Contains 100g,CAS 94-09-7 (45ZG94)? Graingers got your back. Price:$46.30. Easy ordering & convenient delivery. Log-in or register for your pricing.
Shfaqja e lythat në lëkurë gjithmonë shkakton iritim dhe parehati. Por kur ka lythat gjenitale ose lythat gjenitale dy herë frustruese, sepse përveç paraqitjes ato janë ende sëmundjet seksualisht...
Abolition of duty free goods within the EU: On 30 June 1999, the sale of duty-free alcohol and tobacco at airports and at sea was abolished in all of the original 15 EU member states. Of the 10 new member states that joined the EU on 1 May 2004, these rules already apply to Cyprus and Malta. There are transitional rules in place for visitors returning to one of the original 15 EU countries from one of the other new EU countries. But for the original 15, plus Cyprus and Malta, there are now no limits imposed on importing tobacco and alcohol products from one EU country to another (with the exceptions of Denmark, Finland and Sweden, where limits are imposed). Travellers should note that they may be required to prove at customs that the goods purchased are for personal use only. ...
Malonaldehyde, a very reactive member of the homologous series of dialdehydes, is associated with the autoxidative deterioration of lipids. Its measurement, in autoxidized lipid systems is an expression of the extent of oxidation, in lipids. Malonaldehyde lends itself well to such determinations because of the sensitivity and specificity of its quantification in complex lipid systems. Complete knowledge of the formation of malonaldehyde in autoxidized lipids. is lacking. Such knowledge would undoubtedly promote a better understanding of lipid autoxidation mechanisms. In this investigation, a method for detecting malonaldehyde through the use of its reaction with p-aminobenzoic acid was developed. This was adapted for use in measuring malonaldehyde in lipids and in tissue samples. The reaction between p-aminobenzoic acid and malonaldehyde was partially characterized, and a mechanism for the formation of the reaction product was postulated. The quantification of malonaldehyde in lipid systems by ...
Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus ...
Donald Devereux Woods was born in Ipswich in 1912. He was educated at Northgate School, Ipswich. He became a Scholar at Trinity College, Cambridge, graduating in 1933 with first class honours in both parts of the Natural Science Tripos. After graduating, he moved to the Sir William Dunn School of Biochemistry, Cambridge, where he worked with Dr. Marjory Stephenson. Their research focused primarily on indole production and bacterial metabolism. He took his Ph.D. in 1937. From 1936-1939 he was the Beit Memorial Research Fellow. In 1939, Woods was the Halley-Stewart Research Fellow at the Medical Research Council Unit for Bacterial Chemistry (Director: Sir Paul Fildes) at the Bland-Sutton Institute, part of Middlesex Hospital. There his research focused primarily on the determination of p-aminobenzoic acid (PAB) as an antisulphanilamide factor. This research was interrupted by the outbreak of war. He served as a member of the scientific staff at the Medical Research Council. He was seconded to the ...
Preview - Issue 42/2006 Angewandte Chemie Highlights Asymmetric Synthesis Tsuji-Trost Allylic Alkylation with Ketone Enolates M. Braun and T. Meier An FeVI Nitride: There Is Plenty of Room at the Top! High Oxidation States P. J. Chirik 1 Reviews Green Chemistry 1 Hydrogen Peroxide Synthesis: An Outlook beyond the Anthraquinone Process J. L. G. Fierro et al. Communications Microporous Materials 2 F. P. Gabba0 et al. Molecular Recognition 3 F. W. Scheller et al. Oxidative C C Coupling 4 Hydrocarbon Uptake in the Alkylated Micropores of a Columnar Supramolecular Solid (Cover Picture) 2 A Bifunctional Molecularly Imprinted Polymer (MIP): Analysis of Binding and Catalysis by a Thermistor Intermolecular Oxidative Enolate Heterocoupling P. S. Baran and M. P. DeMartino Antibiotics Total Synthesis of Platensimycin 3 K. C. Nicolaou et al. Heterogeneous Catalysis S. L. Buchwald et al. Domino Cu-Catalyzed C N Coupling/ Hydroamidation: A Highly Efficient Synthesis of Nitrogen Heterocycles Natural Products ...
The biosynthetic origin of the $meta$-C$\sb7$N unit of the naphthoquinoid chromophore of the streptovaricins was shown to be 3-amino-5-hydroxybenzoic acid (AHBA) through carbon-14 and carbon-13 labeling studies. ($Carboxy$-$\sp{14}$C) AHBA was incorporated at a rate of 0.1% into streptovaricin C, and ($carboxy$-$\sp{13}$C) AHBA gave an enrichment factor of 21 for the resonance corresponding to the C-21 carbonyl in the $\sp{13}$C NMR spectrum of labeled streptovaricin C. The optimization of incorporation of labeled glucose and the production of mutants of Streptomyces spectabilis are also discussed. A detailed analysis of the $\sp1$H and $\sp{13}$C NMR spectra of streptovaricin C is described ...
1. Detailed Local Anesthetic Drug Benzocaine HCL 23239-88-5 Benzocaine Hydrochloride 2. Qucik Details: Product name: Benzocaine hydrochloride Other name: ETHYL 4-AMINOBENZOATE HYDROCHLORIDE;BENZOCAINE HCL;BENZOCAINE HYDROCHLORIDE;Benzocaine...
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Pantogar Capsule is used for hair damage, cardiovascular diseases, premenstrual syndrome, mental disorders, vitamin b5 deficiency, fibrotic skin disorders and other conditions. Pantogar Capsule contains the following active ingredients: Calcium- D-Pantothenate, Keratin, L- Cysteine, Medicianl Yeast, P- Aminobenzoic Acid, and Thiamine.
In this experiment you will be finding out how much 2-hydroxybenzoic acid (salicylic acid) is present in 2-ethanoyloxybenzenecarboxylic acid (aspirin) tablets.
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Ambrx is developing proprietary antibody-drug conjugates (ADCs) for both oncology and non-oncology indications, including inflammation. The research programme
Manufacturer and supplier of cGMP grade Benzocaine API. We are a manufacturer of Benzocaine API and NOT a distributor. Drug Master File (DMF) is available for pharmaceutical grade products.
Product Name: 3-Aminophenol Synonyms: 1-Amino-3-hydroxybenzene;1-amino-3-hydroxybenzene[qr];3-amino-1-hydroxybenzene[qr];3-amino-pheno;3-hydroxyaniline[qr];3-Hydroxyanilinel AC;3-hydroxybenzenamine;Basf ursol eg CAS: 591-27-5 MF: C6H7NO MW: 109.13...
Proposed reaction mechanism for catalysis of the ring-cleavage of 2-aminophenol by APD. The O atoms from O2 are highlighted in red. ...
Rifamycin S chemical properties, What are the chemical properties of Rifamycin S 13553-79-2, What are the physical properties of Rifamycin S ect.
Pinx1 - Pinx1 (untagged) - Mouse PIN2/TERF1 interacting, telomerase inhibitor 1 (Pinx1), (10ug) available for purchase from OriGene - Your Gene Company.
Benzocaine glucoside/AFI28315506 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
2017.08.17 - [K.30418] Kur Nopirkt Hgh Tableti Vangaži Latvija. Kur nopirkt HGH Pill Vangaži Latvija? Mēs apspriež lietojumiem, drošības informāciju un blakusparādības HGH (cilvēka augšanas hormona).
... Fredricks, K. T., Gingerich, W. H., and Fater, D. C., 1993, Comparative cardiovascular effects of four fishery anesthetics in spinally transected rainbow trout, Oncorhynchus mykiss: Comparative Biochemistry and Physiology C, v. 104C, no. 3, p. 477-483.. Abstract. We compared the effects of four anesthetics on heart rate, dorsal and ventral aortic blood pressure, and electrocardiograms of rainbow trout (Oncorhynchus mykiss ). Exposure to the local anesthetics tricaine methanesulfonate (MS-222) and benzocaine hydrochloride (BZH) produced minimal cardiovascular alterations. Mean dorsal aortic pressure (DAP) decreased during exposure to MS-222, and mean DAP and mean ventral aortic pressure (VAP) increased 15% during recovery from BZH. Exposure to the general anesthetic 2-phenoxyethanol (2-PE) or the hypnotic agent etomidate (ET) dramatically decreased heart rate and blood ...
Acetyl coenzyme A-dependent N-acetyltransferase and O-acetyltransferase activities were examined in liver cytosols derived from homozygous rapid acetylator C57BL/6J and A.B6 congenic inbred mouse strains, from homozygous slow acetylator A/J and B6.A congenic inbred mouse strains, and from the (C57BL/6J x A/J)F1 heterozygous acetylator hybrid mouse strain. Acetylator genotype-dependent N-acetyltransferase activity was exhibited for the N-acetylation of p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl. In contrast, levels of isoniazid N-acetyltransferase and N-hydroxy-3,2-dimethyl-4-aminobiphenyl O-acetyltransferase activities in mouse liver cytosol appeared to be independent of the arylamine Nat acetylator gene. Although cytosolic N-acetyltransferase activities differed about 2-fold between the parental C57BL/6J and A/J strains for p-aminobenzoic acid, 2-aminofluorene, and 4-aminobiphenyl, the same N-acetyltransferase activities differed about 6-7-fold between the homozygous rapid ...
Methods are described for controlling exocrine pancreatic function, for reducing the level of amylase in the blood, and for treating pancreatitis in an individual comprising administering to the individual a bone morphogenetic protein (BMP). Methods for identifying candidate molecules for use in treating diabetes are also described.
OBJECTIVE: To determine the exocrine pancreatic function in critically ill patients. DESIGN: Prospective cohort study. SETTING: Medical intensive care unit. PATIENTS: A total of 18 critically ill patients (11 patients with septic shock according to t
The therapeutic potential of gallic acid and its derivatives as anti-cancer, antimicrobial and antiviral agents is well known. We have examined the mechanism by which natural gallic acid and newly synthesized gallic acid alkyl esters and related protocatechuic acid alkyl esters inhibit HIV-1 protease to compare the influence of the aromatic ring substitutions on inhibition. We used Zhang-Poormans kinetic analysis and fluorescent probe binding to demonstrate that several gallic and protecatechuic acid alkyl esters inhibited HIV-1 protease by preventing the dimerization of this obligate homodimeric aspartic protease rather than targeting the active site. The tri-hydroxy substituted benzoic moiety in gallates was more favorable than the di-substituted one in protocatechuates. In both series, the type of inhibition, its mechanism and the inhibitory efficiency dramatically depended on the length of the alkyl chain: no inhibition with alkyl chains less than 8 carbon atoms long. Molecular dynamics simulations
162 μM, Na2MoO4 4.86 × 10−2 μM; (c) Vitamins: Biotin 8.19 nM, Folic acid 4.53 nM, Thiamine hydrochloride (B1) 0.148 μM, Riboflavin 0.133 μ M, Pyridoxine hydrochloride (B6) 48.6 μM, Cyanocobalamin (B12) 7.38 × 10−2 nM, Nicotinic acid 40.6 nM, D-Calcium pantothenate 20.9 nM, p-Aminobenzoic acid 36.5 nM, Thioctic acid 24.2 nM. The pH of the basal elements solution was adjusted to 4.5 with 20% (m/v) NaOH. Trace elements and vitamins were prepared in 10000-fold concentrated stock solutions and added to the basal solution after autoclaving Fedratinib chemical structure at 120°C for 20 min. Analysis by qPCR of Phanerochaete chrysosporium AAD1 gene expression The expression of Pc AAD1 during Nitrogen-limited cultivation was analyzed by real-time. PCR (qPCR). The frozen mycelia were disrupted with TissueLyser II grinder for 2 x 1.5 min at 30 s−1 frequency (Qiagen SAS, Courtaboeuf, France) and total RNA was purified from c.a. 100 mg wet-mycelium with the RNeasy Plant Mini Kit (Qiagen) ...
Kefiran is a water-soluble polysaccharide extracted from kefir grains biomass. The identification and quantification of kefiran monosaccharides were carried out by HPTLC after the complete acid hydrolysis of kefiran solutions. The mobile phase was a mixture of n-propanol: acetic acid: water (70:20:10, v/v). For derivatization was used p-aminobenzoic acid and o-phosphoric acid in methanol. The identified HPTLC fractions were glucose (Rf 0.71) and galactose (Rf 0.66), which indicates a high purity of the extracted kefiran. The relative concentrations of each monosaccharide identified in samples are dependent on the initial molecular weight of the polymer chain. The kefiran isolated from kefir grains grown in milk is a heteropolysaccharide which contains D-glucose and D-galactose units in a ratio of 0.94:1.1 ...
Kefiran is a water-soluble polysaccharide extracted from kefir grains biomass. The identification and quantification of kefiran monosaccharides were carried out by HPTLC after the complete acid hydrolysis of kefiran solutions. The mobile phase was a mixture of n-propanol: acetic acid: water (70:20:10, v/v). For derivatization was used p-aminobenzoic acid and o-phosphoric acid in methanol. The identified HPTLC fractions were glucose (Rf 0.71) and galactose (Rf 0.66), which indicates a high purity of the extracted kefiran. The relative concentrations of each monosaccharide identified in samples are dependent on the initial molecular weight of the polymer chain. The kefiran isolated from kefir grains grown in milk is a heteropolysaccharide which contains D-glucose and D-galactose units in a ratio of 0.94:1.1 ...
Duodenal calcium and magnesium concentrations after pancreatic stimulation were measured in 25 patients with and without pancreatic disease. The concentration of both ions was higher in those with pancreatic disease, and furthermore these patients showed a different secretory pattern. These findings may be relevant to the aetiology of pancreatitis and to pancreatic calcification, and might be of diagnostic value.. ...
Methods and compositions for treating cancer and other diseases in which inhibition of telomerase activity can ameliorate disease symptoms or prevent or treat the disease relate to compounds that are derivatives of benzo b!thiophenes. Such compounds are characterized by the following structure: ##STR1## In this compound, R1 is selected from the group consisting of --OR7, --NR8 R9, --NHNR10 R11, --NHNHC(X2)NHR12, --NHSO2 NR8 R9, --NHNHC(O)R12, --NHNHSO2 R12 and --NHC(O)NR8 R9. R7 -R12 are selected independently from the group consisting of hydrogen, alkyl, aryl, aralkyl, heteroaryl and heteroaralkyl. X1 and X2 are selected independently from the group consisting of oxygen and sulfur. R2 is hydrogen or halogen. R3 -R6 are selected independently from the group consisting of hydrogen, halogen, hydroxyl, --NR8 R9, nitro, cyano, alkoxyl, lower alkyl, aryl and aryloxyl.
The investigational drug DEDN6526A, which is a new member of a class of drugs called antibody-drug conjugates, was safe, tolerable, and showed hints of activity against different forms of melanoma-cutaneous, mucosal, and ...
Herbimycin A, 1 mg. Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2).
Eardrops With Benzocaine Were Never Approved. The U.S. Food and Drug Administration (FDA) is warning that eardrops with benzocaine were never approved.
EnGeneIC is developing bacterially-derived EDV™ nanocells, loaded with a cytotoxic drug, and externally coated with bispecific antibodies targeting the
From the Manufacturer:This infamous flavor combination has Girl Scouts running out of stock across the nation and these raw cacao morsels are the real deal! Kur Cacao Mint are so full of decadent flav… Read more… ...
The function of a linker in an antibody-drug conjugate is to covalently connect its effector moiety, the cytotoxic drug, with its targeting moiety, the antibody. In this chapter, we review various...
Mastopatia - një sëmundje mjaft e zakonshme e grave, e cila ishte e varur nga mosha e gruas. Kur Inflamacioni i gjirit është i gjirit degjenerimi indeve që shkakton tumoret beninje. Sot ne e dim...
Two sulfur-containing ansamycin antibiotics were isolated from the culture broth of Streptomyces albolongus C-46366; the major one was identical with awamycin and the minor one was a new ansamycin antibiotic, ansathiazin. Their structures were elucid
The sulfonamides are bacteriostatic agents and the spectrum of activity is similar for all. Sulfonamides inhibit bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with aminobenzoic acid through competitive inhibition of the enzyme dihydropteroate synthetase. Resistant strains have altered dihydropteroate synthetase with reduced affinity for sulfonamides or produce increased quantities of aminobenzoic acid. Topically applied sulfonamides are considered active against susceptible strains of the following common bacterial eye pathogens: Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, and Enterobacter species. Topically applied sulfonamides do not provide adequate coverage against Neisseria species, Serratia marcescens and Pseudomonas aeruginosa. A significant percentage of staphylococcal isolates are completely resistant to sulfa drugs. ...
Deoxyribonucleate (DNA) preparations were extracted from Neisseria meningitidis (four isolates from spinal fluid and blood) and N. gonorrhoeae strains, all of which were resistant to sulfadiazine upon primary isolation. These DNA preparations, together with others from in vitro mutants of N. meningitidis and N. perflava, were examined in transformation tests by using as recipient a drug-susceptible strain of N. meningitidis (Ne 15 Sul-s Met+) which was able to grow in a methionine-free defined medium. The sulfadiazine resistance typical of each donor was introduced into the uniform constitution of this recipient. Production of p-aminobenzoic acid was not significantly altered thereby. Transformants elicited by DNA from the N. meningitidis clinical isolates were resistant to at least 200 μg of sulfadiazine/ml, and did not show a requirement for methionine (Sul-r Met+). DNA from six strains of N. gonorrhoeae, which were isolated during the period of therapeutic use of sulfonamides, conveyed lower degrees
1. The literature on conditions affecting the activity of proteolytic enzymes has been reviewed.. 2. Experimental data on the control of the activity of trypsin, leucoprotease, papain, serum antiprotease, leucopeptidase, and pancreatic peptidase have been presented. These data indicate that:. (a) The polymorphonuclearleucocytes of the cat contain abundant proteinase and peptidase active at neutral pH; those of the rabbit lack proteinase active at neutral pH.. (b) Reducing agents, including several biologically important thiol-sulfhydryl compounds and ascorbic acid, inhibit the activity of leucoprotease and trypsin. For each reductant the degree of inhibition is proportional to the reducing capacity of the medium.. (c) p-Aminobenzoic acid, sulfonamides (especially sulfathiazole), and many diphenyl sulfones inhibit the activity of leucoprotease.. (d) Serum, plasma, several heavy metals, ammonium salts, asparagine, thiourea, heparin, glutamic acid, tyrothricin, calcium chloride, and bile salts and ...
Nelumbo nucifera Gaertn, belonging to the family Nymphaeaceae, commonly known as lotus, is a perennial aquatic plant distributed over the world, especially in India, China, Japan, Korea, Russia, and some African countries. The seeds of N. nucifera have been used as traditional medicine for treatment of nervous disorders, insomnia, high fevers, hematemesis, hematuria, hypertension, and stopping of bleeding. There have been many biological reports on the Nelumbinis Semen, however, its biological principles have not been studies intensively. Therefore, the dried Nelumbinis Semen were subjected to detailed laboratory phytochemical investigation. Four compounds 45-48 were isolated from the EtOAc extracts (300 g) and identified as 4-hydroxybenzoic acid methyl ester, 4-hydroxybenzoic acid ethyl ester, 4-hydroxybenzoic acid propyl ester, and 4-hydroxybenzoic acid butyl ester, respectively, by comparison of their spectral data with the published values. In addition, the paraben derivatives 45-48 were ...
Solution and solid-state properties of m-hydroxybenzoic acid have been investigated. Two polymorphs were found where the monoclinic modification exhibits a higher stability than the orthorhombic form. The solubility of the monoclinic polymorph was determined between 10 and 50 degrees C in methanol, acetonitrile, acetic acid, acetone, water and ethyl acetate. The solubility of the orthorhombic polymorph was determined between 10 and 50 degrees C in acetonitrile, acetic acid, acetone and ethyl acetate. A thermodynamic analysis revealed a marked correlation between the molar solubility and the vant Hoff enthalpy of solution at constant temperature. In addition, in each solvent increased temperature resulted in increased vant Hoff enthalpy of solution. It is shown that the solubility data can be used to estimate melting properties for both polymorphs. The solubility ratio of the two forms and the DSC thermogram of the orthorhombic form strongly suggest that the system is monotropic. However, ...
Renchao Zhang, MD, Jiafei Yan, MD, Yiping Mou, MD, FACS, Yucheng Zhou, MD, Chaojie Huang, Chao Lu, Ronggao Chen. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University. Background:Enucleation is an alternative procedure for treating benign or lowgrade malignant neoplasms of the pancreas. The studies on laparoscopic enucleation(LE) versus open enucleation(OE) have not been as readily available. This study aimed to compare perioperative outcomes of patients undergoing LE and OE and to assess the pancreatic function after LE.. Methods:A retrospective study was performed for patients who underwent LE or OE between 2001 and 2013. The patients demographic data, operative results, pathological reports, hospital courses, morbidity and mortality, and follow-up data (including pancreatic function) were compared between these two groups.. Results:Thirty-nine enucleation (laparoscopic=13, open=26) were performed during the study period. Baseline characteristics were similar between ...

Patent US6462303 - Laser marking of golf balls - Google PatentsPatent US6462303 - Laser marking of golf balls - Google Patents

Trimethylene glycol-di-p-aminobenzoates are sold under trade names POLAMINES by Polaroid Corporation. N,N′-dialkyldiamino ...
more infohttp://www.google.com/patents/US6462303?dq=6519629

Aminobenzoates - DrugBankAminobenzoates - DrugBank

Meradimate is used as an active ingredient in sunscreens or as a sunblock factor in different products. It fits under the category of broad-spectrum absorbent agent. These characteristics are important to consider due to the fact that this kind of ingredients can either absorb or reflect UV radiation. It is also important to know the type of rays that cover. UVA rays are the responsible of causing sun damage and reaching deeper layers of the skin while UVB can only cause sunburn in the outer layer of the skin. When an agent is of broad spectrum, this means that this agent is capable of acting in both UVA and UVB rays.[L2749 ...
more infohttps://www.drugbank.ca/categories/DBCAT000585

para-Aminobenzoates - DrugBankpara-Aminobenzoates - DrugBank

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
more infohttps://www.drugbank.ca/categories/DBCAT000584

Dicopper(II) Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures  - ePrints@IIScDicopper(II) Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures - [email protected]

Dicopper(II) Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures ... Schiff base aminobenzoates with discrete molecular and 1D-chain polymeric structures. In: Polyhedron, 23 (13). pp. 2177-2182. ...
more infohttp://eprints.iisc.ernet.in/2585/

RCSB PDB - BHA Ligand Summary PageRCSB PDB - BHA Ligand Summary Page

Aminobenzoates. *Aminosalicylic Acid and Derivatives. *Aminosalicylic Acids. *Anti-Bacterial Agents. *Anti-Infective Agents ...
more infohttps://www.rcsb.org/ligand/BHA

Center for Theoretical & Mathematical Sciences   » PeopleCenter for Theoretical & Mathematical Sciences » People

... ortho-Aminobenzoates • Osmolar Concentration • Oxidative Stress • Oxygen • Oxygen Consumption • Phenothiazines • Phenotype • ...
more infohttp://fds.duke.edu/db/aas/math/ctms/faculty/hfn

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (Dermatologic Agents); 0 (Gels); 0 (Transforming Growth Factor beta1); 0 (ortho-Aminobenzoates); HVF50SMY6E (tranilast). ... 0 (Dietary Fiber); 0 (Plant Extracts); 0 (Receptors, LDL); 0 (avenanthramide-2C); 0 (ortho-Aminobenzoates); 97C5T2UQ7J ( ... 0 (Aza Compounds); 0 (Drug Combinations); 0 (Insecticides); 0 (Macrolides); 0 (Spiro Compounds); 0 (ortho-Aminobenzoates); ... 0 (Antineoplastic Agents); 0 (Histone Deacetylase Inhibitors); 0 (Thiocarbamates); 0 (ortho-Aminobenzoates); EC 3.5.1.98 ( ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D02.241.223.100.050.400

Wound and skin care compositions - Kimberly-Clark Worldwide, Inc.Wound and skin care compositions - Kimberly-Clark Worldwide, Inc.

... o-amino-benzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); salicylates ...
more infohttp://www.freepatentsonline.com/8524771.html

Patente US2382546 - Anesthetic solutions - Google PatentesPatente US2382546 - Anesthetic solutions - Google Patentes

Levulinic acid salts of amino benzoates. US2569403 *. 13 Jul 1946. 25 Sep 1951. American Cyanamid Co. Soluble calcium salts. ...
more infohttp://www.google.es/patents/US2382546

US8206730B2 - Sunscreen composite particles and porous particles in cosmetic compostions 
        - Google PatentsUS8206730B2 - Sunscreen composite particles and porous particles in cosmetic compostions - Google Patents

... o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); Salicylates (octyl ...
more infohttps://patents.google.com/patent/US8206730B2/en

US7892524B2 - Sunscreen composite particles 
        - Google PatentsUS7892524B2 - Sunscreen composite particles - Google Patents

... o-aminobenzoates; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl esters); Salicylates (octyl ...
more infohttps://patents.google.com/patent/US7892524B2/en

The Potential of Hydrocarbon Chemotaxis to Increase Bioavailability and Biodegradation Efficiency | SpringerLinkThe Potential of Hydrocarbon Chemotaxis to Increase Bioavailability and Biodegradation Efficiency | SpringerLink

Parales RE (2004) Nitrobenzoates and aminobenzoates are chemoattractants for Pseudomonas strains. Appl Environ Microbiol 70:285 ...
more infohttps://link.springer.com/referenceworkentry/10.1007/978-3-319-50542-8_3

Application # 2017/0348991. INKJET PRINTING OF PEARLESCENT AND METALLIC COLOURS - Patents.comApplication # 2017/0348991. INKJET PRINTING OF PEARLESCENT AND METALLIC COLOURS - Patents.com

... aminobenzoates. [0122] When one or more co-initiators are included into the UV curable inkjet ink, preferably these co- ...
more infohttp://patents.com/us-20170348991.html

US Patent # 1,003,9193. Etch-resistant inkjet inks for manufacturing conductive patterns - Patents.comUS Patent # 1,003,9193. Etch-resistant inkjet inks for manufacturing conductive patterns - Patents.com

The preferred co-initiators are aminobenzoates. When one or more co-initiators are included into the UV curable inkjet ink, ...
more infohttp://patents.com/us-10039193.html

Patent US3878229 - Sun-screening compounds III - Google PatentsPatent US3878229 - Sun-screening compounds III - Google Patents

P - (2 - alkyloxy - benzoyl) - aminobenzoates of n - dialkylamine - alkyl and their quaternary salts. ...
more infohttp://www.google.com/patents/US3878229?dq=5343970

Multi component controlled delivery system for soap bars - SHEFER ADIMulti component controlled delivery system for soap bars - SHEFER ADI

Sunscreens can be classified into five groups based upon their chemical structure: para-amino benzoates; salicylates; ...
more infohttp://www.freepatentsonline.com/y2005/0065047.html

MantADP binding kinetics to RecG⋅DNA.MantADP at vario | Open-iMantADP binding kinetics to RecG⋅DNA.MantADP at vario | Open-i

MantADP binding kinetics to RecG⋅DNA.MantADP at various concentrations was mixed in the stopped flow apparatus with 0.5 µM RecG and 2.5 µM DNA (A40:B40) und
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3368886_pone.0038270.g005&req=4

Aminobenzoate decarboxylase - WikipediaAminobenzoate decarboxylase - Wikipedia

McCullough WG, Piligian JT, Daniel IJ (1957). "Enzymatic decarboxylation of three aminobenzoates". J. Am. Chem. Soc. 79 (3): ...
more infohttps://en.wikipedia.org/wiki/Aminobenzoate_decarboxylase

Cerebral Hemorrhage, Traumatic; Brain Hemorrhage, Cerebral, Traumatic; Cerebral Hematoma, Traumatic; Intracerebral Hemorrhage,...Cerebral Hemorrhage, Traumatic; Brain Hemorrhage, Cerebral, Traumatic; Cerebral Hematoma, Traumatic; Intracerebral Hemorrhage,...

Cerebral Hemorrhage, Traumatic; Brain Hemorrhage, Cerebral, Traumatic; Cerebral Hematoma, Traumatic; Intracerebral Hemorrhage, Traumatic. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
more infohttps://lookfordiagnosis.com/results.php?symptoms=Cerebral+Hemorrhage%2C+Traumatic%3B%20Brain%20Hemorrhage%2C%20Cerebral%2C%20Traumatic%3B%20Cerebral%20Hematoma%2C%20Traumatic%3B%20Intracerebral%20Hemorrhage%2C%20Traumatic&lang=1&parent=%2F&mode=F&therapy_ap=1

Department of Chemistry. Aristotle University of ThessalonikiDepartment of Chemistry. Aristotle University of Thessaloniki

"On the bioreactivity of triorganotin aminobenzoates. Investigation of trialkyl and triarylyltin(IV) esters of 3- amino and 4- ... "Structural elucidation for the triorganotin aminobenzoates. Crystal structures of triphenyltin 4-aminobenzoate and trimethyl ...
more infohttp://www.chem.auth.gr/index.php?mn=63&sc=1

Titanium Dioxide in Sunscreen | IntechOpenTitanium Dioxide in Sunscreen | IntechOpen

These include aminobenzoates, anthralates, cinnamates, salicylates, benzophenones, dibenzoylmethane, and camphor to name a few ...
more infohttps://www.intechopen.com/books/application-of-titanium-dioxide/titanium-dioxide-in-sunscreen

Patente US4330649 - Process for producing olefin polymers or copolymers - Google PatentesPatente US4330649 - Process for producing olefin polymers or copolymers - Google Patentes

... hydroxybenzoates and aminobenzoates. Alkyl esters, for example C1 -C8 alkyl esters, are preferred. Methyl p-toluate and ethyl p ...
more infohttp://www.google.es/patents/US4330649?dq=flatulence

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