Enzymes that catalyze the transfer of an aminoacyl group from donor to acceptor resulting in the formation of an ester or amide linkage. EC 2.3.2.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.
Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the removal of water. EC 4.2.1.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.
MYCOBACTERIUM infections of the lung.
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
Tuberculosis resistant to ISONIAZID and RIFAMPIN and at least three of the six main classes of second-line drugs (AMINOGLYCOSIDES; polypeptide agents; FLUOROQUINOLONES; THIOAMIDES; CYCLOSERINE; and PARA-AMINOSALICYLIC ACID) as defined by the CDC.
Acquiring information from a patient on past medical conditions and treatments.
The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A mitochondrial protein consisting of four alpha-subunits and four beta-subunits. It contains enoyl-CoA hydratase, long-chain-3-hydroxyacyl-CoA dehydrogenase, and acetyl-CoA C-acyltransferase activities and plays an important role in the metabolism of long chain FATTY ACIDS.
The beta subunit of mitochondrial trifunctional protein that contains acetyl-CoA C-acyltransferase activity. There are four of these beta subunits in each trifunctional protein complex.
The alpha subunit of mitochondrial trifunctional protein. It contains both enoyl-CoA hydratase activity (EC 4.2.1.17) and long-chain-3-hydroxyacyl-CoA dehydrogenase activity (EC 1.1.1.211). There are four of these alpha subunits in each mitochondrial trifunctional protein molecule.
Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the CoA ester of a fatty acid two carbons shorter is formed.
An NAD-dependent 3-hydroxyacyl CoA dehydrogenase that has specificity for acyl chains containing 8 and 10 carbons.
Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones.
The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4.
The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.
Formation of an acetyl derivative. (Stedman, 25th ed)
Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.

AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution. (1/414)

Phytochelatins, a class of posttranslationally synthesized peptides, play a pivotal role in heavy metal, primarily Cd2+, tolerance in plants and fungi by chelating these substances and decreasing their free concentrations. Derived from glutathione and related thiols by the action of gamma-glutamylcysteine dipeptidyl transpeptidases (phytochelatin synthases; EC 2.3.2.15), phytochelatins consist of repeating units of gamma-glutamylcysteine followed by a C-terminal Gly, Ser, or beta-Ala residue [poly-(gamma-Glu-Cys)n-Xaa]. Here we report the suppression cloning of a cDNA (AtPCS1) from Arabidopsis thaliana encoding a 55-kDa soluble protein that enhances heavy-metal tolerance and elicits Cd2+-activated phytochelatin accumulation when expressed in Saccharomyces cerevisiae. On the basis of these properties and the sufficiency of immunoaffinity-purified epitope-tagged AtPCS1 polypeptide for high rates of Cd2+-activated phytochelatin synthesis from glutathione in vitro, AtPCS1 is concluded to encode the enzyme phytochelatin synthase.  (+info)

Phytochelatin synthase genes from Arabidopsis and the yeast Schizosaccharomyces pombe. (2/414)

Phytochelatins (PCs), a family of heavy metal-inducible peptides important in the detoxification of heavy metals, have been identified in plants and some microorganisms, including Schizosaccharomyces pombe, but not in animals. PCs are synthesized enzymatically from glutathione (GSH) by PC synthase in the presence of heavy metal ions. In Arabidopsis, the CAD1 gene, identified by using Cd-sensitive, PC-deficient cad1 mutants, has been proposed to encode PC synthase. Using a positional cloning strategy, we have isolated the CAD1 gene. Database searches identified a homologous gene in S. pombe, and a mutant with a targeted deletion of this gene was also Cd sensitive and PC deficient. Extracts of Escherichia coli cells expressing a CAD1 cDNA or the S. pombe gene catalyzing GSH-dependent, heavy metal-activated synthesis of PCs in vitro demonstrated that both genes encode PC synthase activity. Both enzymes were activated by a range of metal ions. In contrast, reverse transcription-polymerase chain reaction experiments showed that expression of the CAD1 mRNA is not influenced by the presence of Cd. A comparison of the two predicted amino acid sequences revealed a highly conserved N-terminal region, which is presumed to be the catalytic domain, and a variable C-terminal region containing multiple Cys residues, which is proposed to be involved in activation of the enzyme by metal ions. Interestingly, a similar gene was identified in the nematode, Caenorhabditis elegans, suggesting that PCs may also be expressed in some animal species.  (+info)

Tolerance to toxic metals by a gene family of phytochelatin synthases from plants and yeast. (3/414)

Phytochelatins play major roles in metal detoxification in plants and fungi. However, genes encoding phytochelatin synthases have not yet been identified. By screening for plant genes mediating metal tolerance we identified a wheat cDNA, TaPCS1, whose expression in Saccharomyces cerevisiae results in a dramatic increase in cadmium tolerance. TaPCS1 encodes a protein of approximately 55 kDa with no similarity to proteins of known function. We identified homologs of this new gene family from Arabidopsis thaliana, Schizosaccharomyces pombe, and interestingly also Caenorhabditis elegans. The Arabidopsis and S.pombe genes were also demonstrated to confer substantial increases in metal tolerance in yeast. PCS-expressing cells accumulate more Cd2+ than controls. PCS expression mediates Cd2+ tolerance even in yeast mutants that are either deficient in vacuolar acidification or impaired in vacuolar biogenesis. PCS-induced metal resistance is lost upon exposure to an inhibitor of glutathione biosynthesis, a process necessary for phytochelatin formation. Schizosaccharomyces pombe cells disrupted in the PCS gene exhibit hypersensitivity to Cd2+ and Cu2+ and are unable to synthesize phytochelatins upon Cd2+ exposure as determined by HPLC analysis. Saccharomyces cerevisiae cells expressing PCS produce phytochelatins. Moreover, the recombinant purified S.pombe PCS protein displays phytochelatin synthase activity. These data demonstrate that PCS genes encode phytochelatin synthases and mediate metal detoxification in eukaryotes.  (+info)

Functional characterization of the D-Tyr-tRNATyr deacylase from Escherichia coli. (4/414)

The yihZ gene of Escherichia coli is shown to produce a deacylase activity capable of recycling misaminoacylated D-Tyr-tRNATyr. The reaction is specific and, under optimal in vitro conditions, proceeds at a rate of 6 s-1 with a Km value for the substrate equal to 1 microM. Cell growth is sensitive to interruption of the yihZ gene if D-tyrosine is added to minimal culture medium. Toxicity of exogenous D-tyrosine is exacerbated if, in addition to the disruption of yihZ, the gene of D-amino acid dehydrogenase (dadA) is also inactivated. Orthologs of the yihZ gene occur in many, but not all, bacteria. In support of the idea of a general role of the D-Tyr-tRNATyr deacylase function in the detoxification of cells, similar genes can be recognized in Saccharomyces cerevisiae, Caenorhabditis elegans, Arabidopsis thaliana, mouse, and man.  (+info)

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. (5/414)

Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein specified by srtA, sortase, may be a useful target for the development of new antimicrobial drugs.  (+info)

Evidence for tissue-specific forms of glutaminyl cyclase. (6/414)

Glutaminyl cyclase (QC) is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. An examination of the bovine tissue distribution of QC immunoreactivity, enzyme activity, and mRNA confirmed that QC was abundant in brain and pituitary by all three measures. However, enzymatic activity was considerably more widespread than either immunoreactivity or mRNA, suggesting multiple enzyme forms. Partially purified QC from bovine spleen differed significantly from the known bovine pituitary QC in physical and catalytic properties. We propose that this form of glutaminyl cyclase plays a role in the posttranslational processing of constitutively secreted pGlu-containing proteins.  (+info)

Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells. (7/414)

PURPOSE: To determine the effect of dimethylfumarate (DMF), an inducer of glutathione (GSH)-dependent detoxification, on intracellular GSH levels in cultured human retinal pigment epithelium (hRPE) cells, its mechanism of action, and its effect on hRPE cells subjected to oxidative injury. METHODS: Established hRPE cell lines were treated with DMF and assayed by high-pressure liquid chromatography for intracellular and extracellular GSH levels. Quantification of gamma-glutamylcysteine synthetase (GLCL) was determined through northern and western blot analyses, and activity was measured. Effects of pretreatment with DMF on GSH redox status of hRPE cells was determined. Sensitivity of hRPE cells to oxidative stress was determined using tert-butylhydroperoxide as the oxidative agent. RESULTS: Dimethylfumarate caused a transient decrease followed by a significant increase in intracellular GSH. Glutathione increased maximally at 24 hours with 100 to 200 microM DMF. The initial decrease could be accounted for by the formation of a DMF-GSH conjugate. Dimethylfumarate treatment increased the steady state mRNA expression of the regulatory subunit of GLCL, but no increase was seen for the catalytic subunit. However, protein levels were increased for both, and the catalytic activity of GLCL was also increased. Whereas the initial decrease in GSH made hRPE cells more susceptible to oxidative damage, pretreatment with DMF under conditions that increased intracellular GSH protected hRPE cells against oxidative damage. CONCLUSIONS: These results suggest a means by which the antioxidant capability of hRPE may be augmented without direct antioxidant supplementation. Specifically, a dietary compound that conjugates with GSH can induce GSH synthesis, increase GSH concentration, and improve protection by GSH-dependent detoxification pathways in hRPE. However, the early depletion of GSH before stimulated synthesis necessitates caution in prevention strategies using dietary inducers.  (+info)

Spread of drug-resistant Streptococcus pneumoniae in Asian countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study. (8/414)

Antimicrobial susceptibility of 996 isolates of Streptococcus pneumoniae from clinical specimens was investigated in 11 Asian countries from September 1996 to June 1997. Korea had the greatest frequency of nonsusceptible strains to penicillin with 79.7%, followed by Japan (65.3%), Vietnam (60.8%), Thailand (57.9%), Sri Lanka (41.2%), Taiwan (38.7%), Singapore (23.1%), Indonesia (21.0%), China (9.8%), Malaysia (9.0%), and India (3.8%). Serotypes 23F and 19F were the most common. Pulsed-field gel electrophoresis (PFGE) of 154 isolates from Asian countries showed several major PFGE patterns. The serotype 23F Spanish clone shared the same PFGE pattern with strains from Korea, Japan, Singapore, Taiwan, Thailand, and Malaysia. Fingerprinting analysis of pbp1a, pbp2x, and pbp2b genes of 12 strains from six countries also showed identical fingerprints of penicillin-binding protein genes in most strains. These data suggest the possible introduction and spread of international epidemic clones into Asian countries and the increasing problems of pneumococcal drug resistance in Asian countries for the first time.  (+info)

p,Sortase cysteine transpeptidases covalently attach proteins to the bacterial cell wall or assemble fiber-like pili that promote bacterial adhesion. Members of this enzyme superfamily are widely distributed in Gram-positive bacteria that frequently utilize multiple sortases to elaborate their peptidoglycan. Sortases catalyze transpeptidation using a conserved active site His-Cys-Arg triad that joins a sorting signal located at the C terminus of their protein substrate to an amino nucleophile located on the cell surface. However, despite extensive study, the catalytic mechanism and molecular basis of substrate recognition remains poorly understood. Here we report the crystal structure of the Staphylococcus aureus sortase B enzyme in a covalent complex with an analog of its NPQTN sorting signal substrate, revealing the structural basis through which it displays the IsdC protein involved in heme-iron scavenging from human hemoglobin. The results of computational modeling, molecular dynamics ...
Zn(II)-dependent glutaminyl cyclase (QC) converts N-terminal glutamine or glutamate residues of peptides and proteins. The reaction product is in both cases N-terminal pyroglutamic acid (pyroGlu). In animals the glutaminyl cyclization is involved in posttranslational modification and activation of peptide-based hormone and chemokine precursors. Recently it was established that the driving force in neurodegenerative processes is the pyroGlu modification at the N-terminus of Aβ peptides processed by QC. This unveils the inhibition of QC as a strategy in AD treatment. The enzyme-specific inhibition is required in order to avoid noxious side effects. The elucidation of the reaction mechanism might make possible the development of mechanism-based QC inhibitors (e.g. transition-state analog compounds). Mechanistic and structural investigations were accomplished using the mitochondrial isoform of QC from Drosophila melanogaster. Regarding enzyme kinetic and structural properties, this enzyme is highly ...
Glutaminyl cyclase (QC) catalyzes the cyclization of N-terminal glutamine residues into pyroglutamate. This post-translational modification extends the half-life of peptides and, in some cases, is essential in binding to their cognate receptor. Due to its potential role in the post-translational modification of tick neuropeptides, we report the molecular, biochemical and physiological characterization of salivary gland QC during the prolonged blood feeding of the black-legged tick (Ixodes scapularis) and the gulf-coast tick (Amblyomma maculatum). QC sequences from I. scapularis and A. maculatum showed a high degree of amino acid identity to each other and other arthropods and residues critical for zinc binding/catalysis (D159, E202, and H330) or intermediate stabilization (E201, W207, 0248, D305, F325, and W329) are conserved. Analysis of QC transcriptional gene expression kinetics depicts an upregulation during the bloodmeal of adult female ticks prior to fast-feeding phases in both I. scapularis and A
Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo-peptidases. pE-Aβ species have been identified as major constituents of Aβ plaques and reduction of pE-Aβ species is associated with improvement of cognitive tasks in animal models of Alzheimers disease (AD). Pharmacological inhibition of QC has thus emerged as a promising therapeutic approach for AD. Here, we question whether cerebrospinal fluid (CSF) QC enzymatic activity differs between AD patients and controls and whether inflammatory or angiogenesis mediators, some of which are potential QC substrates, and/or Aβ peptides may serve as pharmacodynamic read-outs for QC inhibition. QC activity, Aβ peptides and inflammatory or angiogenesis mediators were measured in CSF of a clinically well-characterized cohort of 20 mild AD patients, 20 moderate AD patients and 20 subjective memory
Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo-peptidases. pE-Aβ species have been identified as major constituents of Aβ plaques and reduction of pE-Aβ species is associated with improvement of cognitive tasks in animal models of Alzheimers disease (AD). Pharmacological inhibition of QC has thus emerged as a promising therapeutic approach for AD. Here, we question whether cerebrospinal fluid (CSF) QC enzymatic activity differs between AD patients and controls and whether inflammatory or angiogenesis mediators, some of which are potential QC substrates, and/or Aβ peptides may serve as pharmacodynamic read-outs for QC inhibition. QC activity, Aβ peptides and inflammatory or angiogenesis mediators were measured in CSF of a clinically well-characterized cohort of 20 mild AD patients, 20 moderate AD patients and 20 subjective memory
BioAssay record AID 752868 submitted by ChEMBL: Inhibition of human glutaminyl cyclase expressed in HEK293 cells using L-glutaminyl-beta-naphthylamine as substrate after 1 hr by fluorometric analysis.
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
Bacillus subtilis codes for two putative sortases, YhcS and YwpE, and two surface proteins, YhcR and YfkN, harboring sorting motifs supposed to be recognized by the putative sortase(s). However, there is no experimental evidence to show a direct link between these sortases and sorting sequences. To study the role of these two putative sortases on displaying YhcR and YfkN on the cell wall, expression of yhcS and ywpE was analyzed by transcriptional fusions and by Northern blot. It turned out that yhcS gene is expressed at a higher level during the late stationary phase from both experiments, while ywpE expression is not confirmed in the Northern blot analysis. Next, we constructed yhcS and ywpE single and double knockout strains and plasmids that express one or both genes to restore the functions of the knockout strains. It could be shown that display of YhcR and YfkN on the surface depended on the presence of YhcS while YwpE seems not to play a major role if any as a sortase. Finally, the putative
TY - JOUR. T1 - Functional analysis of Clostridium difficile sortase B reveals key residues for catalytic activity and substrate specificity. AU - Huang, I-Hsiu. PY - 2020. Y1 - 2020. M3 - Article. JO - Journal of Biological Chemistry. JF - Journal of Biological Chemistry. SN - 0021-9258. ER - ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
The subject of N-acyl amino acid conjugates has been rapidly growing in recent years, especially with regard to their analgesic and anti-inflammatory actions. The field is comprised of a large family of lipid signaling molecules whose importance is only now being fully realized. The most widely studied member is N-arachidonoyl glycine (NAGly), which differs structurally from the endocannabinoid anandamide (N-arachidonoyl ethanolamide) by a single oxygen atom and the two are metabolically related. Topics that are covered in this mini review are: biosynthetic pathways for N-acyl amino acids, receptors for N-acyl amino acids, physiological actions of N-acyl amino acids, pharmacological effects of N-acyl amino acids and molecular mechanisms believed to be responsible for their effects ...
Research within the past decade has revealed that a large fraction of bacterial surface proteins are covalently anchored to the cell wall by the action of sortase enzymes, in a universally conserved process that is important for infectivity. This chapter presents a review of the structural basis of sortase-mediated cell wall anchoring, drawing on recent structural, biochemical, and bioinformatic studies of this enzyme family. In addition to embedding proteins into the underlying membrane (e.g., membrane proteins and lipoproteins), gram-positive bacteria have developed several methods to display surface proteins, each with its own distinctive structural features. It has long been known that some proteins in gram-positive bacteria are covalently linked to the cell wall, but the enzymes that place them there have only recently been identified. SrtA-related proteins were found in nearly all gram-positive bacteria with sequenced genomes and, in several cases, were demonstrated to be key determinants of
Qpct - Qpct (untagged) - Mouse glutaminyl-peptide cyclotransferase (glutaminyl cyclase) (Qpct), (10ug) available for purchase from OriGene - Your Gene Company.
Song, I., Chuang, C., Bateman, R. C. (1994). Molecular-Cloning, Sequence-Analysis and Expression of Human Pituitary Glutaminyl Cyclase. Journal of Molecular Endocrinology, 13(1), 77-86 ...
Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) versus UCP1(-) adipocytes. We??demonstrate that PM20D1 is a bidirectional enzyme in??vitro, catalyzing both the condensation of fatty acids and amino acids to generate N-acyl amino acids and also the reverse hydrolytic reaction. N-acyl amino acids directly bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration. Mice with increased circulating PM20D1 have augmented respiration and increased N-acyl amino acids in blood. Lastly, administration of N-acyl amino acids to mice improves glucose homeostasis and increases energy expenditure. These data identify an enzymatic node and a family of metabolites that regulate energy homeostasis. This pathway might be ...
Complete information for ATE1 gene (Protein Coding), Arginyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Schmohl, Lena; Bierlmeier, Jan; von Kuegelgen, Nicolai; Kurz, Leonie; Reis, Pascal; Barthels, Fabian; Mach, Pia; Schutkowski, Mike; Freund, Christian; Schwarzer, Dirk ...
Cohesion between sister chromatids is established during DNA replication and depends on a protein complex called cohesin. At the metaphase-anaphase transition in the yeast Saccharomyces cerevisiae, the ESP1-encoded protease separin cleaves SCC1, a subunit of cohesin with a relative molecular mass of 63,000 (Mr 63K). The resulting 33K carboxy-terminal fragment of SCC1 bears an amino-terminal arginine-a destabilizing residue in the N-end rule. Here we show that the SCC1 fragment is short-lived (t1/2 approximately 2 min), being degraded by the ubiquitin/proteasome-dependent N-end rule pathway. Overexpression of a long-lived derivative of the SCC1 fragment is lethal. In ubr1Delta cells, which lack the N-end rule pathway, we found a highly increased frequency of chromosome loss. The bulk of increased chromosome loss in ubr1Delta cells is caused by metabolic stabilization of the ESP1-produced SCC1 fragment. This fragment is the first physiological substrate of the N-end rule pathway that is targeted through
Schilling, S.; Stenzel, I.; von Bohlen, A.; Wermann, M.; Schulz, K.; Demuth, H.-U.; Wasternack, C. Isolation and characterization of the glutaminyl cyclases from ,i,Solanum tuberosum,/i, and ,i,Arabidopsis thaliana,/i,: implications for physiological functions Biol. Chem 388, 145-153, (2007) ...
Schilling, S.; Stenzel, I.; von Bohlen, A.; Wermann, M.; Schulz, K.; Demuth, H.-U.; Wasternack, C. Isolation and characterization of the glutaminyl cyclases from ,i,Solanum tuberosum,/i, and ,i,Arabidopsis thaliana,/i,: implications for physiological functions Biol. Chem 388, 145-153, (2007) ...
Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth HU, Schilling S. Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics ...
With the increasing availability of small molecules, drug-like libraries, and robotic automation, the search for sortase inhibitors has now entered the era of high-throughput screening. A screen of 1000 diverse compounds for inhibition of sortase yielded a diarylacrylnitrile with an IC50 of 231 μM (Oh et al., 2004). Examination of the structure-activity relationships of this compound indicated placing the two benzene rings in the trans-orientation as a (Z)-diarylacrylonitrile lowered the IC50 to 28 μM. Further structure-activity relationship indicated that a 2,5-dimethoxy configuration was the most potent with a competitive inhibition profile. Dialysis and activity recovery experiments suggested that inhibition was reversible. Modeling studies suggested further that the phenyl rings of the inhibitor may interact with lipophilic residues of the sortase substrate binding pocket. Future work on this class of inhibitors will be needed to achieve a structural appreciation of sortase ...
Bacterial sortases have been widely studied for their usefulness in protein modification, however, the variable substrate specificity and activity between homologs of these enzymes is not yet fully characterized. To attempt to further understand sorting signal recognition, we are working towards a substrate bound structure of sortase A from Streptococcus pneumoniae (SrtApneu). This enzyme displays a wide tolerance for alternate amino acids within the canonical LPXTG sorting motif. Our strategy involves a non-cleavable substrate analog that can be docked into the active site, allowing for elucidation of a structure displaying the key contacts that allow the enzyme to recognize alternate sorting signals. To this end, ketomethylene-linked
Im in. ,, -----Original Message----- ,, From: isdc2006-bounces at nss.org [mailto:isdc2006-bounces at nss.org] On ,, Behalf Of Pat Montoure ,, Sent: Friday, March 03, 2006 7:32 AM ,, To: isdc 2006; Mat Kaplan ,, Subject: [ISDC2006] ISDC2006 Committee telecon ,, ,, Better late than never. ,, ,, Reminder for our ISDC organizing committee telecon on Sunday Mar 5, 2006 ,, at 1:00pm Pacific / 4:00pm Eastern time. ,, ,, Call in: 888-387-8686 ,, Room code: 6863339# ,, ,, Agenda: ,, ,, 1. Introductions ,, 2. General updates ,, 3. Programming - Pat / George ,, A. Track Chairs Reports ,, 4. Programming Book - Track Chairs: Lisa Kaspin is going to be putting ,, together the program book. She will need Bio, Photos (if possible) and a ,, small (3-4 sentances) paragraph about speakers, and subject matter. ,, 5. Videographer for ISDC ,, 6. Responsibility reports ,, A. Big name speakers - George and Bruce ,, B. Thurs night Gala - Space Tourism Soc ,, C. Registration ,, D. Hotel - Please send any ...
The present invention provides compounds of the formula: |chemistry-cwu id=CHEM-US-00001 st32-name=CHEM-US|1|image id=EMI-C00001 he=74.9007 wi=85.4469 file=US20040167191A1-20040826-C00001
K2SrTa2O7 crystallizes in the tetragonal I4/mmm space group. The structure is three-dimensional. K1+ is bonded in a 5-coordinate geometry to nine O2- atoms. There are a spread of K-O bond distances ranging from 2.78-3.08 Å. Sr2+ is bonded to twelve O2- atoms to form SrO12 cuboctahedra that share corners with four equivalent SrO12 cuboctahedra, faces with four equivalent SrO12 cuboctahedra, and faces with eight equivalent TaO6 octahedra. There are eight shorter (2.79 Å) and four longer (2.84 Å) Sr-O bond lengths. Ta5+ is bonded to six O2- atoms to form TaO6 octahedra that share corners with five equivalent TaO6 octahedra and faces with four equivalent SrO12 cuboctahedra. The corner-sharing octahedra tilt angles range from 0-11°. There are a spread of Ta-O bond distances ranging from 1.87-2.12 Å. There are three inequivalent O2- sites. In the first O2- site, O2- is bonded in a distorted linear geometry to four equivalent Sr2+ and two equivalent Ta5+ atoms. In the second O2- site, O2- is
Phytochelatin synthases (PC synthases) are soluble enzymes that catalyse the synthesis of heavy metal‐binding peptides termed phytochelatins (PCs) from the tripeptide glutathione (GSH) and related peptides
Our data show that knockout of the arginyltransferase Ate1 in the cells of the neural crest lineage results in multiple morphogenic defects and perinatal lethality in mice. It has been previously shown that complete Ate1 knockout in mice leads to embryonic lethality and defects in cardiovascular development and angiogenesis [9] that are reminiscent of the defects seen in mouse models with knockout of genes implicated in cell adhesion and migration during embryogenesis [10]. Here we show for the first time that Ate1 deletion in the migratory subpopulations of the neural crest cells leads to delayed development and reduced size of the neural crest-derived organs and tissues, suggesting that Ate1-dependent migration of the neural crest cells is essential for normal embryogenesis.. We have previously shown that Ate1 knockout embryonic fibroblasts have leading edge defects that arise from abnormalities in the non-arginylated actin cytoskeleton [24]. Here we found that in addition to the abnormal ...
PC synthesis is activated both in vivo and in vitro by some metal ions to which the corresponding PC synthase mutant is not hypersensitive. For example, both the expressed Arabidopsis enzyme in vitro and PC synthesis in vivo (P.B. Goldsbrough, unpublished data) are efficiently activated by Cu. However, the cad1-3 mutant is only slightly more sensitive to Cu than is the wild type. Similarly, Zn activates both the expressed S. pombe enzyme in vitro and PC synthesis in S. pombe in vivo (Grill et al., 1986), but the PC synthase-deficient mutant is not more sensitive to Zn than is the wild type. Although PC synthesis may be activated in vivo by particular metal ions, PCs may play little or no role in their detoxification. This may be due, for example, to inefficient sequestration to the vacuole and an inability to form stable complexes or to the operation of other more effective mechanisms for the detoxification of these metals. Together, these observations indicate that in vitro data on the relative ...
Numerous studies suggest that the majority of Aβ peptides deposited in Alzheimers Disease (AD) is truncated and post-translationally modified at the N-terminus. Among these modified species, pyroglutamyl-Aβ (pE-Aβ including N3pE-Aβ42) has been identified as particularly neurotoxic. The N-terminal modification renders the peptide hydrophobic, accelerates formation of oligomers and reduces degradation by peptidases leading ultimately to the accumulation of the peptide and progression of AD. It has been shown, that the formation of pyroglutamyl residues is catalysed by glutaminyl cyclase (QC). Here, we present data about the pharmacological in vitro and in vivo efficacy of the QC-inhibitor PQ912, the first-in-class compound that is in clinical development. PQ912 inhibits human, rat and mouse QC-activity with Ki-values in the range between 20 and 65 nM. Chronic oral treatment of hAPPSLxhQC double transgenic mice applying approximately 200 mg/kg/day via chow shows a significant reduction of ...
Compounds and uses | Therapeutically active compounds and their methods of use | Crystalline forms of a biphenyl compound | Pyrimidine compounds for the treatment of hepatitis C | Inhibitors of glutaminyl cyclase |
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
These are the general reagents used for all ligation reactions. Discussion of the specific reagents will be in each individual protocol. Sortase: A Sortase A construct with the N-terminal membrane targeting sequence removed is readily purified in N-terminally His-tagged form. The pETMCSIII based vector pLLC064 is available for expression of this construct. The protein is easily overexpresed and purified using standard nickel affinity chromatography conditions. It should be noted that the protein migrates anomalously on SDS-PAGE gels and appears to run as a protein of ~26 kDa molecular weight (###). We have confirmed the correct molecular weight of Sortase A expressed from pLLC064 by MS. The protein is very stable. We find it convenient to store the protein in Sortase buffer (50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, pH 7.5). The protein appears stable to multiple freeze-thaw cycles. We have not as yet investigated the potential to freeze dry Sortase for storage although we hope to carry out this ...
This chapter reviews what is known about surface proteins of Staphylococcus aureus, their mechanisms of anchoring to the cell wall envelope, and their contributions to the pathogenesis of staphylococcal infections. Protein A amino acid sequence, gene sequence, and three dimensional nuclear magnetic resonance and X-ray diffraction structures revealed a molecule comprised of five nearly identical Ig-binding domains as well as the molecular elements involved in binding Ig. S. aureus strains clump in the presence of plasma; this phenomenon, which has been exploited for diagnostic purposes, is the product of a molecular interaction between two microbial surface components recognizing adhesive matrix molecules (MSCRAMMS), clumping factor A and B, with fibrinogen. Both S. aureus and S. epidermidis strains encode for multiple cell wall-anchored surface proteins with large serine-aspartate repeat (Sdr) domains. In addition to the subset of S. aureus sortase-anchored cell wall surface proteins that are covalently
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Competing interests HN reports other from Intermune, other from Roche, other from Boehringer- Ingelheim, other from Sanofi, during the conduct of the study; other from Centocor, outside the submitted work; DV reports personal fees from Intermune, personal fees from Roche, personal fees from Boehringer Ingelheim, personal fees from Intermune, Roche, Boehringer Ingelheim, outside the submitted work. Dr AG reports grants and personal fees from Boehringer, personal fees from Roche, outside the submitted work. GP reports personal fees from Actelion, Bayer, Boehringer Ingelheim, GSK, Roche, outside the submitted work. VC reports personal fees from Actelion, Bayer, Biogen Idec, Boehringer Ingelheim, Gilead, GSK, MSD, Novartis, Pfizer, Roche/Intermune, Sanofi, grants from Actelion, Boehringer Ingelheim, GSK, Pfizer and Roche and personal fees from Boehringer Ingelheim, outside the submitted work. All other authors have no competing interests to declare. ...
TY - JOUR. T1 - Transgenic Indian mustard (Brassica juncea) plants expressing an Arabidopsis phytochelatin synthase (AtPCS1) exhibit enhanced As and Cd tolerance. AU - Gasic, Ksenija. AU - Korban, Schuyler S.. N1 - Funding Information: Acknowledgements We would like to thank Dr. Norman Terry for supplying us with Indian mustard seed, including transgenic line GS7, and Dr. Peter Goldsbrough for helping us with PCs analyses. This material is based upon work supported by the Illinois Department of Natural Resources.. PY - 2007/7. Y1 - 2007/7. N2 - Phytochelatins (PCs) are post-translationally synthesized thiol reactive peptides that play important roles in detoxification of heavy metal and metalloids in plants and other living organisms. The overall goal of this study is to develop transgenic plants with increased tolerance for and accumulation of heavy metals and metalloids from soil by expressing an Arabidopsis thaliana AtPCS1 gene, encoding phytochelatin synthase (PCS), in Indian mustard ...
Phytochelatins are small cysteine-rich non-ribosomal peptides that chelate soft metal and metalloid ions, such as cadmium and arsenic. They are widely produced by plants and microbes; phytochelatin synthase genes are also present in animal species from several different phyla, but there is still little known about whether these genes are functional in animals, and if so, whether they are metal-responsive. We analysed phytochelatin production by direct chemical analysis in Lumbricus rubellus earthworms exposed to arsenic for a 28 day period, and found that arsenic clearly induced phytochelatin production in a dose-dependent manner. It was necessary to measure the phytochelatin metabolite concentrations directly, as there was no upregulation of phytochelatin synthase gene expression after 28 days: phytochelatin synthesis appears not to be transcriptionally regulated in animals. A further untargetted metabolomic analysis also found changes in metabolites associated with the transsulfuration ...
Lactobacilli are important for the maintenance of a healthy ecosystem in the human vagina. Various mechanisms are postulated but so far are poorly substantiated by molecular studies, such as mutant analysis. Bacterial autoaggregation is an interesting phenomenon that can promote adhesion to host cells and displacement of pathogens. In this study, we report on the identification of a human vaginal isolate, Lactobacillus plantarum strain CMPG5300, which shows high autoaggregative and adhesive capacity. To investigate the importance of sortase-dependent proteins (SDPs) in these phenotypes, a gene deletion mutant was constructed for srtA, the gene encoding the housekeeping sortase that covalently anchors these SDPs to the cell surface. This mutant lost the capacity to autoaggregate, showed a decrease in adhesion to vaginal epithelial cells, and lost biofilm-forming capacity under the conditions tested. These results indicate that the housekeeping sortase SrtA of CMPG5300 is a key determinant of the ...
This Mouse Glutaminyl-peptide cyclotransferase-like protein (QPCTL) ELISA Kit employs a two-site sandwich ELISA to quantitate QPCTL.,QPCTL; FLJ20084; glutaminyl cyclase-like,QPCTL, also termed Iso-glutaminyl cyclase catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid with liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid with liberation of water. Glutaminyl cyclase (QPCT) catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid liberating ammonia. In contrast, the physiological function of the plant QC is less clear. In case of the enzyme from C. papaya, a role in the plant defence against pathogenic microorganisms was suggested. Putative QCs from other plants were identified by sequence comparisons. The physiological function of these enzymes, however, is still ambiguous.
Genome-scale functional genetic screens are used to identify key genetic regulators of a phenotype of interest. However, the identification of genetic modifications that lead to a phenotypic change requires sorting large numbers of cells, which increases operational times and costs and limits cell viability. Here, we introduce immunomagnetic cell sorting facilitated by a microfluidic chip as a rapid and scalable high-throughput method for loss-of-function phenotypic screening using CRISPR-Cas9. We used the method to process an entire genome-wide screen containing more than 108 cells in less than 1 h-considerably surpassing the throughput achieved by fluorescence-activated cell sorting, the gold-standard technique for phenotypic cell sorting-while maintaining high levels of cell viability. We identified modulators of the display of CD47, which is a negative regulator of phagocytosis and an important cell-surface target for immuno-oncology drugs. The top hit of the screen, the glutaminyl cyclase QPCTL,
Proteins that have a GPI glycolipid modification are acknowledged to be key in the lifecycle of Plasmodium; for example the involvement of the GPI-anchored MSP1 on merozoites in erythrocyte invasion. The enzyme that transfers the preformed GPI to the proteins such as MSP1 is named GPI:protein transamidase, however, studying this enzyme biochemically has been arduous, due to the following hurdles. Firstly, the GPI:protein transamidase functions as a subunit in multidomain complex, some components of which maybe membrane associated, and there are no reports of functional recombinant reconstitution of this complex. Secondly, there are no convenient and sensitive transamidase assays available that are amenable to medium/high throughput studies, even though large small molecule cysteine peptidase inhibitor libraries exist and can be used to studying this enzyme.. Any input/thoughts on how to overcome the aforementioned obstacles in studying the Plasmodium GPI:protein transamidase would be most ...
It has been demonstrated that under static conditions, pili are involved in self-aggregation and modify the architecture of a growing biofilm. To provide a deeper understanding of the role played by pili in biofilm formation, we focused on the influence of different pilins and sortase C on (i) the adhesion of cells to surfaces under dynamic conditions, and (ii) the nanomechanical properties of pili using single-molecule force spectroscopy.
The N-end rule pathway is a proteolytic system where its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an important part of specific degrons called N-degrons. like a scaffold E3 that promotes HR6B/UbcH2-reliant ubiquitylation of H2A and H2B however not H3 and H4 via a system distinct from normal polyubiquitylation. The E3 activity of UBR2 in histone ubiquitylation is activated by dipeptides bearing destabilizing N-terminal residues allosterically. Insufficient monoubiquitylation and polyubiquitylation on UBR2-lacking meiotic chromosomes correlate to problems in dual strand break (DSB) restoration along with other meiotic procedures leading to pachytene arrest at stage IV and apoptosis. A few of these features of UBR2 are found in somatic cells where UBR2 is really a chromatin-binding proteins involved in chromatin-associated ubiquitylation upon DNA damage. UBR2-deficient somatic cells show an array of chromosomal abnormalities ...
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012 ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
2G0B: FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding.
GPI Transamidase Subunit; Involved In Attachment Of Glycosylphosphatidylinositol (GPI) Anchors To Proteins; May Have A Role In Recognition Of The Attachment Signal Or Of The Lipid Portion Of GPI
TY - JOUR. T1 - Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. AU - Zhang, Fangliang. AU - Patel, Devang M.. AU - Colavita, Kristen. AU - Rodionova, Irina. AU - Buckley, Brian. AU - Scott, David A.. AU - Kumar, Akhilesh. AU - Shabalina, Svetlana A.. AU - Saha, Sougata. AU - Chernov, Mikhail. AU - Osterman, Andrei L.. AU - Kashina, Anna. N1 - Funding Information: This work was supported by NIH grants GM104003 and GM117984 and the Pilot Grant from the Mari Lowe Center for Comparative Oncology to A.Ka., ACS IRG 98-277-13, NIH grant GM107333, and Sylvester Comprehensive Cancer Center Developmental Grant to F. Z., and the Intramural Research Programs of the National Library of Medicine to S.A.S.. PY - 2015/7/15. Y1 - 2015/7/15. N2 - Protein arginylation is an emerging post-translational modification that targets a number of metabolic enzymes; however, the mechanisms and downstream effects of this modification are unknown. Here ...
The widely conserved LytR-CpsA-Psr (LCP) family of enzymes in Gram-positive bacteria is known to attach glycopolymers, including wall teichoic acid, to the cell envelope. However, it is undetermined if these enzymes are capable of catalyzing glycan attachment to surface proteins. In the actinobacterium Actinomyces oris, an LCP homolog here named LcpA is genetically linked to GspA, a glycoprotein that is covalently attached to the bacterial peptidoglycan by the housekeeping sortase SrtA. Here we show by X-ray crystallography that LcpA adopts an α-β-α structural fold, akin to the conserved LCP domain, which harbors characteristic catalytic arginine residues. Consistently, alanine substitution for these residues, R149 and R266, abrogates GspA glycosylation, leading to accumulation of an intermediate form termed GspALMM, which is also observed in the lcpA mutant. Unlike other LCP proteins characterized to date, LcpA contains a stabilizing disulfide bond, mutations of which severely affect LcpA ...
Streptococcus agalactiae (Group B Streptococcus or GBS) is a leading cause of invasive infections in neonates whose virulence is dependent on its ability to
Arginine Pyroglutamate Lysine, 100 cps di Ultimate Nutrition acquista al prezzo scontato di €18.30. Visita il nostro catalogo completo di Arginina. Sul nostro sito potrai trovare sconti su tutta la vasta scelta di integratori alimentari. Muscle Nutrition è il tuo store di fiducia.
List of all the English words with 21 letters containing letter F. aminoacyltransferases, antiferroelectrically, antiferromagnetically, arabinosyltransferase, arylsulfotransferases, arylsulphotransferase, biofunctionalisations, biofunctionalizations
Spot VHH contains a sortase-tag and a His-tag at its C terminus: LPETGHHHHHH. This sequence includes the sortase recognition motif LPETG, for conjugation. In addition, bivalent Spot-VHH may be detected by an anti-His antibody. The Spot VHH corresponds to the BC2-Nanobody used by Virant et al in the publication Nature Communications (2018) doi:10.1038/s41467-018-03191-2.. Biophysical properties ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
Aminoacyltransferases (EC 2.3.2) are acyltransferase enzymes which act upon an amino group. For instance, aminoacyl tRNA ... Aminoacyltransferases at the US National Library of Medicine Medical Subject Headings (MeSH) Biology portal. ...
... aminoacyltransferases MeSH D08.811.913.050.200.400 - gamma-glutamylcyclotransferase MeSH D08.811.913.050.200.500 - gamma- ...
The function of it is not very clear, but it is expected to play a role in association with aminoacyl transferases during their ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
Aminoacyltransferases / genetics * Aminoacyltransferases / metabolism* * Bacterial Outer Membrane Proteins / metabolism* * ...
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen ... Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proceedings of the ...
Aminoacyltransferases * Alanine-tRNA Ligase * Glycine Grant support The funders had no role in study design, data collection ...
Aminoacyltransferases. Sysname. [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin ...
0 (RNA, Transfer, Amino Acyl); 0 (Recombinant Proteins); 2ZD004190S (Threonine); EC 2.3.2.- (Aminoacyltransferases); OF5P57N2ZX ...
2.3.2 Aminoacyltransferases 2.3.3 Acyl groups converted into alkyl groups on transfer ...
2.3.2 - Aminoacyltransferases. Gamma glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme ...
Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proc. Natl. Acad. ...
aminoacyltransferases amino acids -COOH This list is sorted roughly according to decreasing importance. Glucuronidation is the ...
2.3.2 Aminoacyltransferases. 2.3.2.18 N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-triglycine)-D-alanyl-D-alanine- ...
2.3.2 Aminoacyltransferases. 2.3.2.27 RING-type E3 ubiquitin transferase. K04725 XIAP, BIRC4; E3 ubiquitin-protein ligase XIAP ...
Is he trying to refer to aminoacyl transferases?. And Matt G: Thanks. Youre getting warmer, as youre now up to 5 (the former ...
2006) Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proceedings ...
2. 3. 2.- Aminoacyltransferases. 2. 3. 3.- Acyl groups converted into alkyl groups on transfer. 2. 4. -.- Glycosyltransferases ...
Lys3 by the Fem amino-acyltransferases (9). Induction of the vanA gene cluster led to 2 major modifications. First, stem ...
2.3.2.- Aminoacyltransferases *2.3.2.13 Transglutaminases. *2.3.2.27 RING-type E3 ubiquitin transferase ...
The function of it is not very clear, but it is expected to play a role in association with aminoacyl transferases during their ...
Aminoacyltransferases. 2. + +. 135. Hydrocarbons, Aromatic. 2. + +. 136. Pyrimethamine. 2. + +. 137. Lipid A. 2. + +. ...
2.3.2.- Aminoacyltransferases * 2.3.2.27 RING-type E3 ubiquitin transferase. * 2.4.2.1 Purine-nucleoside phosphorylase ...
Aminoacyltransferases (2.3.2). 02013. Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor ...
2.2 Transferring aldehydic or ketonic residues 2.3 Actyltransferases 2.3.1 Acyltransferases 2.3.2 Aminoacyltransferases 2.4 ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
2.3.2: Aminoacyltransferases. *Gamma-glutamyl transpeptidase. *Peptidyl transferase. *Transglutaminase *Tissue transglutaminase ...
It contains three structural motifs typical of class IIa aminoacyl transferases and two signature regions common to histidyl- ...
2.3.2.- Aminoacyltransferases * 2.3.2.27 RING-type E3 ubiquitin transferase. * 2.4.2.1 Purine-nucleoside phosphorylase ...
aminoacyltransferases plural of aminoacyltransferase. → Definition and anagrams of aminoacyltransferases. → Other senses and ...
Aminoacyltransferases. Biosynthetic Pathways. Chile. Copper. Gene Expression Regulation, Enzymologic. Glutamate-Cysteine Ligase ...

No FAQ available that match "aminoacyltransferases"