X-Ray Film: A film base coated with an emulsion designed for use with x-rays.Radiology Information Systems: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.Catalogs, LibrarySoftware: Sequential operating programs and data which instruct the functioning of a digital computer.Catalogs as Topic: Ordered compilations of item descriptions and sufficient information to afford access to them.Sodium-Hydrogen Antiporter: A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Catalogs, UnionTechnology: The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.Sorbic Acid: Mold and yeast inhibitor. Used as a fungistatic agent for foods, especially cheeses.Aminopyridines: Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Food Preservatives: Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Diynes: Compounds with two triple bonds. Some of them are CYTOTOXINS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.CitrullineArginine: An essential amino acid that is physiologically active in the L-form.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Lung Injury: Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.Argininosuccinate Synthase: An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Amino Acid Oxidoreductases: A class of enzymes that catalyze oxidation-reduction reactions of amino acids.Argininosuccinate Lyase: An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.Aromatic-L-Amino-Acid Decarboxylases: An enzyme group with broad specificity. The enzymes decarboxylate a range of aromatic amino acids including dihydroxyphenylalanine (DOPA DECARBOXYLASE); TRYPTOPHAN; and HYDROXYTRYPTOPHAN.Low Density Lipoprotein Receptor-Related Protein-2: An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.Rats, Inbred SHR: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Rats, Inbred WKY: A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Kidney Tubules, Proximal: The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Introns: Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Disaccharides as a new class of nonaccumulated osmoprotectants for Sinorhizobium meliloti. (1/227)

Sucrose and ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid) are very unusual osmoprotectants for Sinorhizobium meliloti because these compounds, unlike other bacterial osmoprotectants, do not accumulate as cytosolic osmolytes in salt-stressed S. meliloti cells. Here, we show that, in fact, sucrose and ectoine belong to a new family of nonaccumulated sinorhizobial osmoprotectants which also comprises the following six disaccharides: trehalose, maltose, cellobiose, gentiobiose, turanose, and palatinose. Also, several of these disaccharides were very effective exogenous osmoprotectants for strains of Rhizobium leguminosarum biovars phaseoli and trifolii. Sucrose and trehalose are synthesized as endogenous osmolytes in various bacteria, but the other five disaccharides had never been implicated before in osmoregulation in any organism. All of the disaccharides that acted as powerful osmoprotectants in S. meliloti and R. leguminosarum also acted as very effective competitors of [14C]sucrose uptake in salt-stressed cultures of these bacteria. Conversely, disaccharides that were not osmoprotective for S. meliloti and R. leguminosarum did not inhibit sucrose uptake in these bacteria. Hence, disaccharide osmoprotectants apparently shared the same uptake routes in these bacteria. Natural-abundance 13C nuclear magnetic resonance spectroscopy and quantification of cytosolic solutes demonstrated that the novel disaccharide osmoprotectants were not accumulated to osmotically significant levels in salt-stressed S. meliloti cells; rather, these compounds, like sucrose and ectoine, were catabolized during early exponential growth, and contributed indirectly to enhance the cytosolic levels of two endogenously synthesized osmolytes, glutamate and the dipeptide N-acetylglutaminylglutamine amide. The ecological implication of the use of these disaccharides as osmoprotectants is discussed.  (+info)

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine. (2/227)

Strain CHR63 is a salt-sensitive mutant of the moderately halophilic wild-type strain Halomonas elongata DSM 3043 that is affected in the ectoine synthase gene (ectC). This strain accumulates large amounts of Ngamma-acetyldiaminobutyrate (NADA), the precursor of ectoine (D. Canovas, C. Vargas, F. Iglesias-Guerra, L. N. Csonka, D. Rhodes, A. Ventosa, and J. J. Nieto, J. Biol. Chem. 272:25794-25801, 1997). Hydroxyectoine, ectoine, and glucosylglycerate were also identified by nuclear magnetic resonance (NMR) as cytoplasmic organic solutes in this mutant. Accumulation of NADA, hydroxyectoine, and ectoine was osmoregulated, whereas the levels of glucosylglycerate decreased at higher salinities. The effect of the growth stage on the accumulation of solutes was also investigated. NADA was purified from strain CHR63 and was shown to protect the thermolabile enzyme rabbit muscle lactate dehydrogenase against thermal inactivation. The stabilizing effect of NADA was greater than the stabilizing effect of ectoine or potassium diaminobutyrate. A (1)H NMR analysis of the solutes accumulated by the wild-type strain and mutants CHR62 (ectA::Tn1732) and CHR63 (ectC::Tn1732) indicated that H. elongata can synthesize hydroxyectoine by two different pathways-directly from ectoine or via an alternative pathway that converts NADA into hydroxyectoine without the involvement of ectoine.  (+info)

A cycle of deprotonation and reprotonation energizing amino-acid transport? (3/227)

Although lowering the pK2 of neutral amino acids only weakens their concentrative uptake by Ehrlich cells, the same change greatly enhances uptake of diamino acids. This effect does not arise merely from putting the distal amino group in its uncharged form, but depends on an enhanced deprotonation of the alpha-amino group. Parallel effects are seen for the transport system for basic amino acids, for which the assignment of pK values within the membrane is less ambiguous. To explain the paradoxical advantages of having the alpha-amino group protonated yet readily deprotonated, we propose that a proton withdrawn from that group is pumped over an intramembrane interval to energize amino-acid transport.  (+info)

The contribution of a conformationally mobile, active site loop to the reaction catalyzed by glutamate semialdehyde aminomutase. (4/227)

The behavior of glutamate semialdehyde aminomutase, the enzyme that produces 4-aminolevulinate for tetrapyrrole synthesis in plants and bacteria, is markedly affected by the extent to which the central intermediate in the reaction, 4,5-diaminovalerate, is allowed to dissociate. The kinetic properties of the wild-type enzyme are compared with those of a mutant form in which a flexible loop, that reversibly plugs the entrance to the active site, has been deleted by site-directed mutagenesis. The deletion has three effects. The dissociation constant for diaminovalerate is increased approximately 100-fold. The catalytic efficiency of the enzyme, measured as k(cat)/K(m) in the presence of saturating concentrations of diaminovalerate, is lowered 30-fold to 2.1 mM(-1) s(-1). During the course of the reaction, which begins with the enzyme in its pyridoxamine form, the mutant enzyme undergoes absorbance changes not seen with the wild-type enzyme under the same conditions. These are proposed to be due to abortive complex formation between the pyridoxal form of the enzyme (formed by dissociation of diaminovalerate) and glutamate semialdehyde itself.  (+info)

Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro. (5/227)

Dengue virus type 2 NS3, a multifunctional protein, has a serine protease domain (NS3pro) that requires the conserved hydrophilic domain of NS2B for protease activity in cleavage of the polyprotein precursor at sites following two basic amino acids. In this study, we report the expression of the NS2B-NS3pro precursor in Escherichia coli as a fusion protein with a histidine tag at the N terminus. The precursor was purified from insoluble inclusion bodies by Ni(2+) affinity and gel filtration chromatography under denaturing conditions. The denatured precursor was refolded to yield a purified active protease complex. Biochemical analysis of the protease revealed that its activity toward either a natural substrate, NS4B-NS5 precursor, or the fluorogenic peptide substrates containing two basic residues at P1 and P2, was dependent on the presence of the NS2B domain. The peptide with a highly conserved Gly residue at P3 position was 3-fold more active as a substrate than a Gln residue at this position. The cleavage of a chromogenic substrate with a single Arg residue at P1 was NS2B-independent. These results suggest that heterodimerization of the NS3pro domain with NS2B generates additional specific interactions with the P2 and P3 residues of the substrates.  (+info)

Ectoine, the compatible solute of Halomonas elongata, confers hyperosmotic tolerance in cultured tobacco cells. (6/227)

1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid (ectoine) functions as a compatible osmolyte in the moderate halophile Halomonas elongata OUT30018. Ectoine is biosynthesized by three successive enzyme reactions from aspartic beta-semialdehyde. The genes encoding the enzymes involved in the biosynthesis, ectA, ectB, and ectC, encoding L-2,4-diaminobutyric acid acetyltransferase, L-2, 4-diaminobutyric acid transaminase, and L-ectoine synthase, respectively, have been previously cloned. To investigate the function of ectoine as a compatible solute in plant cells, the three genes were individually placed under the control of the cauliflower mosaic virus 35S promoter and introduced together into cultured tobacco (Nicotiana tabacum L.) cv Bright Yellow 2 (BY2) cells. The transgenic BY2 cells accumulated a small quantity of ectoine (14-79 nmol g(-1) fresh weight) and showed increased tolerance to hyperosmotic shock (900 mOsm). Furthermore, the transgenic BY2 cells exhibited a normal growth pattern even under hyperosmotic conditions (up to 530 mOsm), in which the growth of the untransformed BY2 (wild type) cells was obviously delayed. These results suggest that genetically engineered synthesis of ectoine results in the increased hyperosmotic tolerance of cultured tobacco BY2 cells despite the low level of accumulation of the solute.  (+info)

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55. (7/227)

Src-homology 3 (SH3) domains recognize PXXP core motif preceded or followed by positively charged residue(s). Whether SH3 domains recognize motifs other than proline-based sequences is unclear. In this study, we report SH3 domain binding to a novel proline-independent motif in immune cell adaptor SKAP55, which is comprised of two N-terminal lysine and arginine residues followed by two tyrosines (i.e. RKxxYxxY). Domains capable of binding to class I proline motifs bound to the motif, while the class II domains failed to bind. Peptide precipitation, alanine scanning and in vivo co-expression studies demonstrated a requirement for the arginine, lysine and tandem tyrosines of the motif. Two-dimensional NMR analysis of the peptide bound FYN-SH3 domain showed overlap with the binding site of a proline-rich peptide on the charged surface of the SH3 domain, while resonance signals for other residues (W119, W120, Y137) were not perturbed by the RKGDYASY based peptide. Expression of the RKGDYASY peptide potently inhibited TcRzeta/CD3-mediated NF-AT transcription in T cells. Our findings extend the repertoire of SH3 domain binding motifs to include a tyrosine-based motif and demonstrate a regulatory role for this motif in receptor signaling.  (+info)

Apolipoprotein E;-low density lipoprotein receptor interaction. Influences of basic residue and amphipathic alpha-helix organization in the ligand. (8/227)

Conserved lysines and arginines within amino acids 140-150 of apolipoprotein (apo) E are crucial for the interaction between apoE and the low density lipoprotein receptor (LDLR). To explore the roles of amphipathic alpha-helix and basic residue organization in the binding process, we performed site-directed mutagenesis on the 22-kDa fragment of apoE (amino acids 1-191). Exchange of lysine and arginine at positions 143, 146, and 147 demonstrated that a positive charge rather than a specific basic residue is required at these positions. Consistent with this finding, substitution of neutral amino acids for the lysines at positions 143 and 146 reduced the binding affinity to about 30% of the wild-type value. This reduction corresponds to a decrease in free energy of binding of approximately 600 cal/mol, consistent with the elimination of a hydrogen-bonded ion pair (salt bridge) between a lysine on apoE and an acidic residue on the LDLR. Binding activity was similarly reduced when K143 and K146 were both mutated to arginine (K143R + K146R), indicating that more than the side-chain positive charge can be important.Exchanging lysines and leucines indicated that the amphipathic alpha-helical structure of amino acids 140-150 is critical for normal binding to the low density lipoprotein receptor.  (+info)

*Diamino acid

Diamino acids belong to the class of amino acids. Asparagine, glutamine and lysine are proteinaceous diamino acids which are ... 6-diaminopimelic acid are non-proteinaceous diamino acids. In biochemistry, diamino acids are of particular interest. Diamino ... These three diamino acids are coded by codons of the genetic material and belong therefore to the cationic amino acids. ... In chemistry, a diamino acid, also called a diamino carboxylic acid, is a molecule containing at least one carboxyl and two ...

*N-Sulfinyl imine

... β-amino acids, syn- and anti-2,3-diamino esters, α-amino aldehydes and ketones, β-amino ketones, α-amino phosphonates, ... Applications to the Synthesis of Nonracemic β-Amino acids and α-hydroxy-β-amino acids". Journal of Organic Chemistry. 57: 6387 ... Davis, Franklin A; Zhou, Ping; Chen, Bang-Chi (1998). "Asymmetric synthesis of amino acids using sulfinimines (thiooxime S- ... Davis, Franklin A; Srirajan, Vaidyanathan; Titus, Donald D (1999). "Efficient Asymmetric Synthesis of β-Fluoro α-Amino Acids". ...

*Strecker amino acid synthesis

A 1,2-diamino-diol is then formed after proton exchange and a nucleophilic attack of water to the former nitrile carbon. ... The amino acid is isolated as its salt with dicyclohexylamine. Asymmetric Synthesis of α-Amino-acids by the Strecker Synthesis ... α-disubstituted amino acids. The traditional synthesis of Adolph Strecker from 1850 gives racemic α-amino nitriles, but several ... The Strecker amino acid synthesis, also known simply as the Strecker synthesis, was discovered by German chemist Adolph ...

*4,4′-Diamino-2,2′-stilbenedisulfonic acid

Structurally, it is a derivative of trans-stilbene, containing amino and sulfonic acid functional groups on each of the two ... 4,4′-Diamino-2,2′-stilbenedisulfonic acid is the organic compound with the formula (H2NC6H3SO3H)2C2H2. It is a white, water- ... It is produced by reduction of 4,4′-dinitro-2,2′-stilbenedisulfonic acid with iron powder. P. F. Vogt, J. J. Gerulis, "Amines, ...

*Murchison meteorite

A specific family of amino acids called diamino acids was identified in the Murchison meteorite as well. The initial report ... decomposition or synthesis of amino acids to occur with protein amino acids but not with non-protein amino acids." In 1997, L- ... Later the amino acid alanine, which is also a protein amino acid, was found to have an excess of the L-configuration, which led ... Although the meteorite contained a mixture of left-handed and right-handed amino acids, most amino acids used by living ...

*Uwe Meierhenrich

doi:10.1073/pnas.0403043101 Meierhenrich et al.: Asymmetric vacuum UV photolysis of the amino acid leucine in the solid state, ... doi:10.1038/416403a Meierhenrich et al.: Identification of diamino acids in the Murchison meteorite, PNAS, 101, S. 9182 - 9186 ... Meierhenrich's name is connected with the identification of amino acids in space. In preparation of the cometary Rosetta- ... doi:10.1002/anie.200501311 Meierhenrich: Amino acids and the asymmetry of life, Springer-Verlag, 2008. ISBN 978-3-540-76885-2 ...

*Divicine

The benzyl group of 2-amino-5-benzyloxy-4-hydroxypyrimidine is removed by acid hydrolysis, yielding 2-amino-4,5- ... Divicine (2,6-diamino-4,5-dihydroxypyrimidine) is an oxidant and a base with alkaloidal properties found in fava beans and ... 2) This intermediate is then treated with nitrous acid to yield the slightly soluble orange product, 2-amino-6- ... A common derivative is the diacetate form (2,6-diamino-1,6-dihydro-4,5-pyrimidinedione). Divicine is found in fava beans and in ...

*Squaric acid

There have been theoretical investigations of the analogous compound obtained by substituting amino groups (-NH2) for the ... hydroxyl (OH) groups to yield 1,2-diamino-3-cyclobutenedione, and of a compound consisting of two squarate rings bridged by (- ... Cyclobutene, C 4H 6 Deltic acid, C 3H 2O 3 Croconic acid, C 5H 2O 5 Rhodizonic acid, C 6H 2O 6 Squaramides, the amides of ... Squaric acid, also called quadratic acid because its four carbon atoms approximately form a square, is an organic compound with ...

*Aspergillomarasmine A

The molecule is a tetracarboxylic acid with four -COOH groups. One section of the molecule is the amino acid aspartic acid. ... 3-diamino-propionic acid. [α]20°D at pH 7 is -48°.[contradictory] With nitrous acid aspergillomarasmine A is deaminated,[ ... Titration reveals changes in ionisation at pK 3.5 and 4.5 due to carboxylic acid groups, and pK 9.5 and 10 due to amino groups ... In P. teres, a biosynthetic precursor of aspergillomarasmine A, L,L-N-(2-amino-2-carboxyethyl)-aspartic acid has also been ...

*DNA glycosylase

The N-terminal 77 amino acids of UNG1 seem to be required for mitochondrial localization, but the presence of a mitochondrial ... The most abundant lesions formed at guanine residues are 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 8-oxoguanine. ... The most N-terminal conserved region contains an aspartic acid residue which has been proposed, based on X-ray structures to ... Nucleic Acids Res. 32 (17): 5291-5302. doi:10.1093/nar/gkh859. PMC 521670 . PMID 15466595. Wu P, Qiu C, Sohail A, Zhang X, ...

*C14H14N2O2S2

Diamino-2,2′-stilbenedisulfonic acid (amsonic acid), an optical brightner. Methyl 2-(((4-sulfamoylphenyl)sulfonyl)amino) ...

*Aminooxyacetic acid

I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino- ... Kitagawa, Matsunosuke; Takani, A. (1936). "Studies on a Diamino Acid, Canavanin, IV. The Constitution of Canavanin and Canalin ... Reed, H.; Meltzer, J.; Crews, P.; Norris, C.; Quine, D.; Guth, P. (1985). "Amino-oxyacetic acid as a palliative in tinnitus". ... Blair, P.; Reed, H. (1986). "Amino-oxyacetic acid: A new drug for the treatment of tinnitus". Journal of the Louisiana State ...

*Alpha-Ketovaleric acid

Unlike related keto acids, it is not an intermediate or metabolite associated with amino acids and its origin is unknown. α- ... 2-diamino-4,5-methylenedioxybenzene as a precolumn fluorescence derivatization reagent". Journal of Chromatography. 430 (2): ... Ketoisovaleric acid 3-Oxopentanoic acid (β-ketovaleric acid) Levulinic acid (γ-ketovaleric acid) Fu, X; Kimura, M; Iga, M; ... α-Ketovaleric acid is a keto acid that is found in human blood. ... liquid chromatographic determination of alpha-keto acids in ...

*Géza Zemplén

... sulphur-containing amino acids, indol-derivatives, and carbohydrates. In the Handbuch der biochemischen Arbeitsmethoden (1912- ... folyóirat 1909) "Synthese der inaktiven α,δ-Diamino valleriansäure und des Prolnis" (with Emil Fischer; Budapest, 1909; ... Folyóirat 1911) "Neue Synthese von Amino-oxysäuren u. von Piperidon-Derivaten" (with Emil Fischer; Budapest, 1910; Berichte der ... "Übers-Amino α-guanido-capronsäure" (Budapest) "Einige Derivate der Cellobiose" (with Emil Fischer; Budapest, 1911; Berichte der ...

*List of IARC Group 3 carcinogens

... para-Aminobenzoic acid 1-Amino-2-methylanthraquinone 2-Amino-4-nitrophenol 2-Amino-5-nitrophenol 4-Amino-2-nitrophenol 2-Amino- ... 9 Dapsone Decabromodiphenyl oxide Deltamethrin Diacetylaminoazotoluene Diallate 1,2-Diamino-4-nitrobenzene 1,4-Diamino-2- ... Parasorbic acid Parathion Patulin Penicillic acid Pentachloroethane Permethrin Perylene Petasitenine Phenanthrene Phenelzine ... Hypochlorite salts Insulation glass wool Iron-dextrin complex Iron sorbitol-citric acid complex Isatidine Isonicotinic acid ...

*Acyl halide

... of the 6-carbon dicarboxylic acid adipic acid. An important use of adipoyl chloride is polymerization with an organic di-amino ... carboxylic acids to form an organic acid anhydrides. In the above reactions, HX (hydrogen halide or hydrohalic acid) is also ... If the acid is a carboxylic acid, the compound contains a -COX functional group, which consists of a carbonyl group singly ... Billions of kilograms are generated annually in the production of acetic acid. The hydroxyl group of a sulfonic acid may also ...

*List of EC numbers (EC 6)

L-amino-acid alpha-ligase EC 6.3.2.29: cyanophycin synthase (L-aspartate-adding) EC 6.3.2.30: cyanophycin synthase (L-arginine- ... 6-diamino-pimelate ligase EC 6.3.2.14: 2,3-dihydroxybenzoate-serine ligase EC 6.3.2.15: Deleted, due to EC 6.3.2.10 EC 6.3.2.16 ... long-chain-fatty-acid-luciferin-component ligase EC 6.2.1.20: long-chain-fatty-acid-(acyl-carrier-protein) ligase EC 6.2.1.21: ... hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) EC 6.3.5.10: adenosylcobyric acid synthase (glutamine- ...

*Isothiocyanate

An artificial isothiocyanate, phenyl isothiocyanate, is used for amino acid sequencing in the Edman degradation. The general ... O'Reilly, RJ; Radom, L (2009). "Ab initio investigation of the fragmentation of 5,5-diamino-substituted 1,4,2-oxathiazoles". ... "Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts". The Journal of ...

*2,5-diaminovalerate transaminase

Other names in common use include diamino-acid transaminase, and diamino acid aminotransferase. It employs one cofactor, ... 5-amino-2-oxopentanoate + L-glutamate Thus, the two substrates of this enzyme are 2,5-diaminopentanoate and 2-oxoglutarate, ... whereas its two products are 5-amino-2-oxopentanoate and L-glutamate. This enzyme belongs to the family of transferases, ...

*Heptazine

The first person to suggest a structure for cyameluric acid was J. Loschmidt, as far back as 1861. His structure was in fact a ... Another melamine homologue, but not a heptazine, is the dimer melam, the fused product of 2,4-diamino-6-chloro-s-triazine with ... The specific compound with three amino substituents is called melem. When heptazine is polymerized with the tri-s-triazine ... The heptazine derivate with three hydroxyl substituents is called cyameluric acid and has many possible tautomeric structures. ...

*TNT

Thus, adsorption of the TNT decomposition product 2,4-diamino-6-nitrotoluene (2,4-DANT) was greater than that for 4-amino-2,6- ... Nitric acid is consumed by the manufacturing process, but the diluted sulfuric acid can be reconcentrated and reused. After ... and then carefully nitrated with a mixture of fuming nitric acid and sulfuric acid. Towards the end of the nitration, the ... The diamino products are energetically less favorable, and even less likely are the triamino products. The transformation of ...

*Iminoborane

If there is a π-electron donating group such as -NR2 connected to B, the neutral Lewis acids can be bonded to the N atom of the ... Die Kristall- und Molekularstruktur von Hexakis(trimethylsilyl)-2,4-diamino-1,3,2,4-diazadiboretidin". Acta Crystallographica ... amino-boration) and R (alkyl-boration). One of these reactions are illustrated here. Cycloaddition is the addition of π bond to ...

*List of EC numbers (EC 1)

L-amino-acid oxidase EC 1.4.3.3: D-amino-acid oxidase EC 1.4.3.4: amine oxidase (flavin-containing) EC 1.4.3.5: pyridoxamine- ... 5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase EC 1.1.1.303: acetoin dehydrogenase EC 1.1.1.304: (S)- ... Delta8-fatty-acid desaturase EC 1.14.19.5: Delta11-fatty-acid desaturase EC 1.14.19.6: Delta12-fatty-acid desaturase EC 1.14. ... L-amino-acid dehydrogenase EC 1.4.1.6: deleted, included in *EC 1.4.4.1 EC 1.4.1.7: serine 2-dehydrogenase EC 1.4.1.8: valine ...

*Oseltamivir total synthesis

In 2006 the group of E.J. Corey published a novel route bypassing shikimic acid starting from butadiene and acrylic acid. The ... Selective acylation with acetic anhydride (under buffered conditions, the 5-amino group is protonated owing to a considerable ... New, Azide-Free Transformation of Epoxides into 1,2-Diamino Compounds: Synthesis of the Anti-Influenza Neuraminidase Inhibitor ... 3-dimethylbarbituric acid in ethanol) and addition of phosphoric acid oseltamivir 16 is obtained. In 2008 the group of Barry M ...

*Hydrogen bond

When the spacing of the amino acid residues participating in a hydrogen bond occurs regularly between positions i and i + 4, an ... V. Réaction anormale de la butanedione avec la diamino-1,2 anthraquinone; structure cristalline de la naphto \2,3-f] ... and also in the solid phase of many anhydrous acids such as hydrofluoric acid and formic acid at high pressure. It is also seen ... Viscosity of anhydrous phosphoric acid and of glycerol Dimer formation in carboxylic acids and hexamer formation in hydrogen ...

*Persistent carbene

NHCs are often strongly basic (the pKa value of the conjugate acid of an imidazol-2-ylidene was measured at ca. 24) and react ... Solé, Stéphane; Gornitzka, Heinz; Schoeller, Wolfgang W.; Bourissou, Didier; Bertrand, Guy (2001). "(Amino)(Aryl)Carbenes: ... 2-Diamino Enols (Breslow Intermediates)". Angew. Chem. Int. Ed. 51: 12370-12374. doi:10.1002/anie.201205878. Chemists Approach ... pKa values for the conjugate acids of several NHC families have been examined in aqueous solution. pKa values of triazolium ...
There is mounting evidence to suggest that environmental factors play a major role in the development of neurodegenerative diseases like ALS (Amyotrophic Lateral Sclerosis). The non-protein amino acid beta-N-methylamino-L-alanine (BMAA) was first associated with the high incidence of Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) in Guam, and has been implicated as a potential environmental factor in ALS, Alzheimers disease, and other neurodegenerative diseases. BMAA has a number of toxic effects on motor neurons including direct agonist action on NMDA and AMPA receptors, induction of oxidative stress, and depletion of glutathione. As a non-protein amino acid, there is also the strong possibility that BMAA could cause intraneuronal protein misfolding, the hallmark of neurodegeneration. While an animal model for BMAA-induced ALS is lacking, there is substantial evidence to support a link between this toxin and ALS. The ramifications of discovering an environmental trigger for ALS
USA] Over the last decade the amino acid beta-N-methylamino-L-alanine (BMAA) has come under intense scrutiny. International laboratory and epidemiological research continues to support the hypothesis that environmental exposure to BMAA (e.g., through dietary practices, water supply) can promote the risk of various neurodegenerative diseases.. A wide variety of cyanobacteria spp. have previously been reported to produce BMAA, with production levels dependent upon species, strain and environmental conditions. Since spirulina (Arthrospira spp.) is a member of the cyanobacteria phylum frequently consumed via dietary supplements, the presence of BMAA in such products may have public health implications.. In the current work, the authors analyzed ten Spirulina-containing samples for the presence of BMAA; six pure Spirulina samples from two separate raw materials suppliers, and four commercially-available multi-ingredient products containing 1.45 g of spirulina per 8.5 g serving. Because of controversy ...
Cox, P.A., Banack, S.A., Murch, S.J., Rasmussen, U., Tien, G., Bigidare, R.R., Metcalfe, J.S., Morrison, L.F., Codd, G.A. & Bergman, B. (2005) Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid. Proceedings of the National Academy of Sciences, 102, 5074-5078 ...
The non-protein amino acid β-methylamino-L-alanine (BMAA) is a neurotoxin present in microalgae and shown to accumulate in the food web. BMAA has been linked to the complex neurodegenerative disorder of Guam and to increased incidents sporadic ALS. Two main neurotoxic routes are suggested; an excitotoxic by acting as an agonist towards glutamate receptors and a metabolic by misincorporating into cellular proteins. We have used zebrafish, an increasingly used model for neurodegenerative diseases, to further identify signaling components involved in BMAA-induced toxicity. Zebrafish embryos were exposed to sub-lethal dosages of BMAA and a label-free proteomics analysis was conducted on larvae 4 days post fertilization. The exposed larvae showed no developmental abnormalities, but a reduced heart rate and increased expression of GSK3 isoforms. Search towards a reviewed database containing 2968 entries identified 480 proteins. Only 17 of these were regulated 2-fold or more in the exposed larvae. ...
Beta Alanine is suitable for anyone who needs explosive power or strength training. Most pre-workout supplements use this ingredient but in a smaller quantitie than a dose of this beta alanine. In this dose, it works not only as a stimulant, but also as fat burner. It also helps in endurance disciplines. Increasing the carnitine concentration in the muscle results in improved performance and prevents the formation of lactic acid (less muscle fever). That is why its very popular among professionals.. Beta alanine delays fatigue, improves endurance, improves muscle strength and performance in any sport. Beta alanine is a non-essential amino acid which can be naturally found in the spectrum of the beta amino acids and together with L-histidine it helps to create carnosine. It is a non-protein amino acid that is not often found in our diet. Beta alanine has been gaining popularity recently and there are more and more studies showing its positive impact on athletes performance. Its been shown to ...
An amino acid-mineral complex, magnesium taurate is formed by chemically bonding the mineral magnesium with the amino acid L-taurine. This water-soluble complex is highly bioavailable and preferred for those looking to support cardiovascular wellness.** Low levels of magnesium are commonly found in the elderly and in premenstrual women, and both groups of people can benefit from taking magnesium supplements.**. Magnesium is an essential mineral with a primary role in enzyme activation; in fact, magnesium is involved in over 300 enzymatic reactions within the body!** It also plays a role in energy production, which is why it is so readily found in the brain, heart, liver, and kidneys.** About 60% of the bodys supply of magnesium is found in the bones, 26% in the muscle, and the rest in soft tissues and bodily fluids. It is naturally found in whole foods, tofu, legumes, seeds, nuts, whole grains, and green leafy vegetables.. Taurine is a non-protein amino acid that is conditionally essential, ...
Recently, lifestyle-related diseases such as diabetes, obesity, hyperlipidemia and hypertension have become a severe problem throughout the world, in terms of both human health and increasing medical expenses. GABA, a ubiquitous non-protein amino acid, is an inhibitory neurotransmitter that has an antihypertensive effect in mammals. GABA is synthesized from L-glutamate by cellular glutamate decarboxylase (GAD). Our lab has reported that rice GAD2ΔC, lacking a C-terminal coding region, conferred an increase in enzymatic activity and its over-expression resulted in extreme GABA accumulation in the calli. In order to accumulate high levels of GABA in rice grains, we performed seed-specific expression of GAD2ΔC using a rice endosperm-specific promoter (glutelin gene, GluB-1) to produce stable lines. Amino acid analysis showed that milled rice grains from transformed rice contain three- to 30-fold higher GABA levels than those from non-transformed rice. We are currently evaluating the effect of a ...
The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings in a calcium, ethylene and abscisic acid-dependent manner. Gene expression is not affected when seedlings are supplied with glutamate, a precursor of GABA. The repression of 14-3-3 gene expression by GABA is dependent on functional ethylene and abscisic acid signalling pathways, since the response is lost in the etr1-1, abi1-1 and abi2-1 mutants. Calcium measurements show that in contrast to glutamate, GABA does not elicit a cytoplasmic calcium elevation, suggesting that the GABA response is unlikely to be mediated by glutamate receptors, as has been suggested previously. We suggest that in addition to its role as a stress-related metabolite, GABA may regulate gene expression in Arabidopsis, including members of the 14-3-3 gene family.. ...
Apple, Stephanie. Radioimmunoassay (RIA) measurement of corticosterone and testosterone in mercury contaminated birds. (Eric Bradley, Biology). Arrington, Justine. Gas-phase H/D Exchange of Protein and Non-protein Amino Acids and Small Peptides. (John Poutsma, Chemistry). Broome, Taylor. A Computational Model of Axonal Loss in Multiple Sclerosis. (Randolph Coleman, Chemistry). Brown, Rachel. Exploration of Meristem Regulation Genes in Arabidopsis Thaliana. (Eric Engstrom, Biology). Chalphin, Alex. The Functional Characterization of GlyT2 and GAD67 Transcriptional Regulation. (Margaret Saha, Biology). Dombrosky, Evan. Nuclear Export of Thyroid Hormone Receptors a and ß. (Lizabeth Allison, Biology). Donaher, Megan. Defining SUMO-interacting motifs (SIMs) of the budding yeast SUMO protease Ulp1. (Oliver Kerscher, Biology). Easterling, Katy. Stop signal reaction time task performance in rats: role of cholinergic and orexigenic systems. (Josh Burk, Psychology). Feresten, Matt. Influence of forest ...
L-Carnitine A dietary supplement to support muscle and cardiovascular functions.* Carnitine is a non-protein amino acid that is biosynthesized in the human liver and naturally occurs in muscle and organ meats. It is intimately involved in the transfer of fatty acids across the membranes of the mitochondria where they can be used to generate energy. Each caplet contains 800 mg Calcium, 250 mg L-Carnitine hydrochloride.Other ingredients: calcium carbonate, cellulose, silica, vegetable stearate, stearic acid.As a dietary supplement take 1 caplet between meals.
Since heart disease is the leading cause of death in the U.S., taking some extra measures to protect your heart is something everyone should consider. New research has discovered that increased levels of homocysteine are a higher risk factor for heart disease than cholesterol.. This non-protein α-amino acid can create inflammation if theres a lack of vitamin B12. In other words, this vitamin reduced the levels of homocysteine, and with that the risk of heart disease and stroke. ...
Complete information for ECTD7 gene (Uncategorized), Ectodermal Dysplasia 7, Hair/Nail Type, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The NM Emory Cardiac Toolbox (ECTb) v4.1 provides advanced tools for cardiac SPECT and PET analysis including comparison of perfusion to viability data, display of 3D images with coronary overlays and gated 3D cine, normal limits for agent match/mismatch as well as optional phase analysis for wall motion and evaluation of thickening. ...
Alfa Aesar is a leading manufacturer and supplier of research chemicals, pure metals and materials for a wide span of applications.
The halophilic bacterium Chromohalobacter salexigens is a natural producer of ectoines, compatible solutes with current and potential biotechnological applications. As production of ectoines is an osmoregulated process that draws away TCA intermediates, bacterial metabolism needs to be adapted to cope with salinity changes. To explore and use C. salexigens as cell factory for ectoine(s) production, a comprehensive knowledge at the systems level of its metabolism is essential. For this purpose, the construction of a robust and high-quality genome-based metabolic model of C. salexigens was approached. We generated and validated a high quality genome-based C. salexigens metabolic model (iFP764). This comprised an exhaustive reconstruction process based on experimental information, analysis of genome sequence, manual re-annotation of metabolic genes, and in-depth refinement. The model included three compartments (periplasmic, cytoplasmic and external medium), and two salinity-specific biomass compositions,
Save 40% Lindberg - Spirulina 500 mg Organic 250 Tablets 100% Organic Spirulina 500 mg Ultimate Organics® Green SuperFood USDA Organic Pesticide and Herbicide Free Double Verified Gluten Free Our 100% Organic Spirulina is a certified organic whole food concentrate, providing a naturally rich source of vitamins, trace minerals, mixed carotenoids, antioxidants, and essential fatty acids. Spirulina provides a vegetarian source of complete protein. Spirulina Platensis contains an exceptionally high amount of C-phycocyanin, a type of algae renowned for its health benefits. Our tablets are 100% organic without herbicides, pesticides, fertilizes or preservatives and tests negative for BMAA. BMAA (beta-N-methylamino-L-alanine) is a toxin sometimes associated with spirulina. Our Ultimate Organics products do not contain conventional pesticides, synthetic fertilizers, growth hormones, genetic modification or antibiotics. We source only natural, organic raw materials that promote the use of renewable resources
The decline in SVC indicated that the drought treatment imposed severe water stress on plants. SVC in a 20-cm soil depth declined to ≈2% after 14 d of drought treatment. Our results demonstrate that GABA- (50 mm) treated perennial ryegrass maintained significantly higher RWC under drought stress than non-treated plants. RWC in leaves is a measure of internal water status during drought stress (Matin et al., 1989). The results suggest that GABA-treated perennial ryegrass plants were better able to maintain water under drought stress. The function of GABA as a compatible osmolyte under osmotic stress has been proposed by Shelp et al. (1999). Osmolyte accumulation in plant cells results in maintenance of cell turgor pressure and also protects cell membranes, protein, and metabolic machinery from cell dehydration (Hare et al., 1998; Ingram and Bartels, 1996; Rathinasabapathi, 2000). Two recent studies demonstrated that GABA was differentially accumulated in hybrid bermudagrass (Cynodon dactylon × ...
Chromohalobacter salexigens ATCC ® BAA-138D-5™ Designation: Genomic DNA from Chromohalobacter salexigens strain DSM 3043 TypeStrain=True Application:
It has been firmly established that organic osmolytes (compatible solutes) of halophilic Bacteria and Archaea have positive effects on conformation and activity of proteins, and may therefore improve their functional production. In particular, the amino acid derivative ectoine is known for its conformational stabilization, aggregation suppression, and radical protection properties. The natural producer and industrial production strain Halomonas elongata accumulates ectoine in the cytoplasm, and as a result offers a unique stabilizing environment for recombinant proteins. For the construction of broad hoast range vector systems with fluorescent reporter proteins, we chose the salt-inducible promoter region of the ectoine gene cluster (promA). A closer inspection of the genetic background revealed that its combination of sigma 38 (σ38) and sigma 70 (σ70) promoters was followed by a weak ribosomal binding site (RBS). This inspired a systematic approach for the construction of a promA-based vector series
The goal of this work was to express the three enzymes that catalyse the synthesis of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid) in the chloroplast of Chlamydomonas reinhardtii. Ectoine is an amino acid derivative that functions in many bacteria as compatible solute, helping the bacteria to survive and grow in highly saline environments. In addition, ectoine is used in cosmetic products, in the medical industry and for biotechnological purposes. There is also a potential relevance to agriculture, as synthesis of ectoine in cells of plants or algae could make them tolerant towards salt concentrations that would normally prohibit growth. There is an ongoing interest in developing efficient production systems for ectoine. Overexpression of ectoine in the chloroplast may lead to both an efficient and economical way to produce ectoine. There are three bacterial genes, ectA, ectB and ectC, that encode the enzymes catalysing ectoine synthesis in bacteria. We wanted to insert the ...
Neurolathyrism is a neurological condition seen among people who eat the seeds of Lathyrus sativus as a principal source of food energy for 2 months or more. It is characterised by severe muscular rigidity and irreversible spastic paralysis of the lower limbs, spinal hyperreflexia, and structural changes of the skeleton and connective tissue (18-19). Once prevalent throughout Europe, N. Africa, the Middle East and parts of the Far East, the disease is presently restricted to India, Bangladesh and Ethiopia (20). The biochemical mechanism involves beta-N-Oxalyl amino-L-alanine (L-BOAA); a synonym is beta-N-oxalyl-alpha,beta-diaminopropionic acid (beta-ODAP). This is a naturally occurring non-protein amino acid present in Blue vetch. Ingestion of L-BOAA in a staple diet results in a progressive neurodegenerative condition, a form of motor neuron disease that affects the upper motor neurons and anterior horn cells of the lumbar spinal cord. L-BOAA is an excitatory acid and acts as an agonist at the ...
δ-Aminolevulinic acid (also dALA, δ-ALA, 5ALA or 5-aminolevulinic acid), an endogenous non-protein amino acid, is the first compound in the porphyrin synthesis pathway, the pathway that leads to heme in mammals and chlorophyll in plants. 5ALA is used in photo dynamic detection and photo dynamic surgery of cancer. Being a precursor of photosensitizer, 5ALA is also used as an agent for photodynamic therapy. Photodynamic detection is the use of photosensitive drugs with a light source of the right wavelength for the detection of cancer, using fluorescence of the drug. 5ALA, or derivatives thereof, can be used to visualize bladder cancer by fluorescence imaging. It elicits synthesis and accumulation of fluorescent porphyrins (protoporphyrin IX) in epithelia and neoplastic tissues, among them malignant gliomas. It is used to visualise tumorous tissue in neurosurgical procedures. Studies since 2006 have shown that the intraoperative use of this guiding method may reduce the tumour residual volume ...
Cell wall and phospholipid composition and their contribution to the salt tolerance of Halomonas elongata.: The salt-tolerant bacterium Halomonas elongata makes
We present a model of osmoadaptation in S.cerevisiae based on existing experimental and theoretical work. In order to investigate the impact of osmoadaptation on glycolysis, this model focuses on the interactions between glycolysis and osmoadaptation, namely the production of glycerol and its influence on flux towards pyruvate. Evaluation of this model shows that, depending on initial relations between glycerol and pyruvate production, the increased glycerol production can have a substantial negative effect on the pyruvate production rate. Existing experimental data and a detailed analysis of the model lead to the suggestion of an interaction between activated Hog1 and activators of glycolysis such as Pfk26.
Nesterenkonia halobia strain DSM 20541 di- and tricarboxylate transporter, diaminobutyric acid acetyltransferase (ectA), diaminobutyric acid aminotransferase (ectB), and ectoine synthase (ectC) genes, complete ...
Nesterenkonia halobia strain DSM 20541 di- and tricarboxylate transporter, diaminobutyric acid acetyltransferase (ectA), diaminobutyric acid aminotransferase (ectB), and ectoine synthase (ectC) genes, complete ...
Tuberculosis (TB) remains to be one of the major public health concerns worldwide. The continuing emergence of Mtb strains resistant to known drugs makes the campaign for successful TB control and treatment very difficult to accomplish. It is therefore imperative to search for newer chemical entities that could inhibit the growing number of putative drug targets for the development of more efficient anti-tubercular drugs. One such ideal target is the 7, 8- diaminopelargonic acid aminotransferase enzyme (BioA). This enzyme is mainly involved in the bacteriums lipid biosynthesis and metabolism machinery, and is considered as a very promising target due to the fact that humans lack this enzyme. In this study, structure-based pharmacophore screening, molecular docking, and ADMET evaluation of compounds obtained from the InterBioScreen Synthetic Compounds (IBS SC) were performed against the MtbBioA enzyme. Five compounds from the library showed more favorable binding energies as compared to the ...
Strand breaks and conformational changes of DNA have consequences for the physiological role of DNA. The natural protecting molecule ectoine is beneficial to entire bacterial cells and biomolecules such as proteins by mitigating detrimental effects of environmental stresses. It was postulated that ectoine-like molecules bind to negatively charged spheres that mimic DNA surfaces. We investigated the effect of ectoine on DNA and whether ectoine is able to protect DNA from damages caused by ultraviolet radiation (UV-A). In order to determine different isoforms of DNA, agarose gel electrophoresis and atomic force microscopy experiments were carried out with plasmid pUC19 DNA. Our quantitative results revealed that a prolonged incubation of DNA with ectoine leads to an increase in transitions from supercoiled (undamaged) to open circular (single-strand break) conformation at pH 6.6. The effect is pH dependent and no significant changes were observed at physiological pH of 7.5. After UV-A irradiation ...
Neurodegenerative diseases are influenced by environmental factors such as exposure to toxins including the cyanotoxin β-N-methylamino-l-alanine (BMAA) that can bioaccumulate in common food sources such as fish, mussels and crabs. Accurate and precise analytical methods are needed to detect and quantify BMAA
germinate.01: GERMINATE-V NOTES: Frame by Jena based on ECTB2, VNcls entity_specific_cos-45.5, sprout. Member of VNcls . entity_specific_cos-45.5, entity_specific_modes_being-47.2. (from germinate.01-v) GERMINATION-N NOTES: Corresponds with germinate.01. Framed by anwen april 2011 (from germination.01-n) ...
In accordance with the invention, nanoscale connectors particularly useful for connecting microscale devices comprise free-standing nanoscale conductors. The nanoscale conductors are conveniently fabricated in sets of controlled, preferably equal length by providing a removable substrate, growing conductive nanotubes or nanowires on the substrate, equalizing the length of the nanoscale conductors, and removing the substrate. Preferably the removable substrate is soluble, leaving a collection of free standing nanoscale connectors in suspension or solution.
inproceedings{252762, author = {Kuo, Yu-Haey and BAU, HM and KHAN, JK and Lambein, Fernand}, booktitle = {Lathyrus sativus and Human Lathyrism : progress and prospects from international collaborators}, isbn = {9845100059}, language = {eng}, pages = {231--234}, publisher = {University of Dhaka}, title = {Detoxification of Lathyrus sativus meal by fermentation without loss of nutritive value}, year = {1995 ...
Planchestainer, Matteo and Contente, Martina Letizia and Cassidy, Jennifer and Molinari, Francesco and Tamborini, Lucia and Paradisi, Francesca (2017) Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata. Green Chemistry, 19 . pp. 372-375. ISSN 1463-9262 Contente, Martina Letizia and Planchestainer, Matteo and Molinari, Francesco and Paradisi, Francesca (2016) Stereoelectronic effects in the reaction of aromatic substrates catalysed by Halomonas elongata transaminase and its mutants. Organic and Biomolecular Chemistry, 14 . pp. 9306-9311. ISSN 1477-0539 ...
This family consists of L-diaminobutyric acid transaminases. This general designation covers both 2.6.1.76 (diaminobutyrate-2-oxoglutarate transaminase, which uses glutamate as the amino donor in DABA biosynthesis), and 2.6.1.46 (diaminobutyrate--pyruvate transaminase, which uses alanine as the amino donor). Most members with known function are 2.6.1.76, and at least some annotations as 2.6.1.46 in current databases at time of model revision are incorrect. A distinct branch of this family contains examples of 2.6.1.76 nearly all of which are involved in ectoine biosynthesis. A related enzyme is 4-aminobutyrate aminotransferase (EC 2.6.1.19), also called GABA transaminase. These enzymes all are pyridoxal phosphate-containing class III aminotransferase ...
CLINTON, NY -Indium Corporations Dr. Ning-Cheng Lee, vice president of technology, will teach a professional development course at the Electronic Components and Technology Conference (ECTC) May 27-30 in Lake Buena Vista, Florida. Lees course, Lead-Free Solder Joint Reliability - Materials Consideration, will cover materials considerations required for achieving high-reliability lead-free solder joints. This course will provide a greater understanding of how various factors contribute to the failure modes, and how to select proper alloys and surface finishes for achieving high-reliability. For more information or to register, visit www.ectc.net. Dr. Lee has extensive experience in the development of solder pastes, fluxes, high-temperature polymers, microelectronics encapsulants, underfills, and adhesives for electronics assembly. His current research interests include advanced materials for interconnects and packaging for electronics and optoelectronics applications, with emphasis on both ...
Microorganisms accumulate molar concentrations of compatible solutes like ectoine to prevent proteins from denaturation. Direct structural or spectroscopic information on the mechanism and about the hydration shell around ectoine are scarce. We combined surface plasmon resonance (SPR), confocal Raman spectroscopy, molecular dynamics simulations, and density functional theory (DFT) calculations to study the local hydration shell around ectoine and its influence on the binding of a gene-S-protein (G5P) to a single-stranded DNA (dT(25)). Due to the very high hygroscopicity of ectoine, it was possible to analyze the highly stable hydration shell by confocal Raman spectroscopy. Corresponding molecular dynamics simulation results revealed a significant change of the water dielectric constant in the presence of a high molar ectoine concentration as compared to pure water. The SPR data showed that the amount of protein bound to DNA decreases in the presence of ectoine, and hence, the protein-DNA ...
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An amino acid that produces tranquilizing effects in the brain, theanine found in green tea, has a significant clinical results for naturally calming as it promotes alpha brain waves, putting you in a state of relaxation without causing drowsiness, according to the study of "L-theanine: properties, synthesis and isolation from tea" Vuong QV, Bowyer MC, Roach PD., posted in Pubmed (http://www.ncbi.nlm.nih.gov/pubmed/21735448), researchers wrote that Theanine is a non-protein amino acid that occurs naturally in the tea plant (Camellia sinensis) and contributes to the favourable taste of tea. It is also associated with effects such as the enhancement of relaxation and the improvement of concentration and learning ability. . It also increases the dopamine levels in the brain, leading to a well-being feeling, according to the study of "The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent" by Nathan PJ, Lu K, Gray M, Oliver C., posted in ...
A number of non-protein amino acid derivatives are found in the natural mushrooms, and a few of them are toxic for a human. We analysed the water soluble low molecular weight compounds of the fruit bodies of Pleurocybella porrigens ("Sugihiratake" in Japanese, angels wings in English) using a high resolution 1H NMR spectroscopy ...
Catalyses the reaction only in the opposite direction. Involved in taurine degradation. The bacterium Chromohalobacter salexigens strain DSM 3043 possesses two enzymes th
1DAM: Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF3-diaminopelargonic acid and enzyme-MgADP-dethiobiotin-phosphate; implications for catalysis.
ID E1VBB7_HALED Unreviewed; 233 AA. AC E1VBB7; DT 30-NOV-2010, integrated into UniProtKB/TrEMBL. DT 30-NOV-2010, sequence version 1. DT 05-JUL-2017, entry version 40. DE SubName: Full=DnaA regulatory inactivator Hda {ECO:0000313,EMBL:CBV42178.1}; GN Name=hda {ECO:0000313,EMBL:CBV42178.1}; GN OrderedLocusNames=HELO_2294 {ECO:0000313,EMBL:CBV42178.1}; OS Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB OS 2198 / 1H9). OC Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales; OC Halomonadaceae; Halomonas. OX NCBI_TaxID=768066 {ECO:0000313,EMBL:CBV42178.1, ECO:0000313,Proteomes:UP000008707}; RN [1] {ECO:0000313,Proteomes:UP000008707} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9 RC {ECO:0000313,Proteomes:UP000008707}; RX PubMed=20849449; DOI=10.1111/j.1462-2920.2010.02336.x; RA Schwibbert K., Marin-Sanguino A., Bagyan I., Heidrich G., Lentzen G., RA Seitz H., Rampp M., Schuster S.C., Klenk H.P., ...
A terapia fotodinâmica antimicrobiana (aPDT) está-se a tornar uma alternativa promissora para inactivar microrganismos patogénicos. Esta terapia consiste na combinação de três elementos não tóxicos, fotosensibilizadores (PS), luz e oxigénio que, quando combinados conduzem à formação de espécies reactivas de oxigénio altamente citotóxicas, nomeadamente o oxigénio singuleto. Estas espécies podem oxidar muitos tipos de moléculas biológicas, como o caso de proteínas, ácidos nucleicos e lípidos. A combinação de grupos com cargas positivas e hidratos de carbono com derivados porfirínicos resulta num aumento de reconhecimento celular e solubilidade em água, melhorando a penetração na membrana celular e acumulação em compartimentos sub-celulares. O objectivo deste trabalho foi sintetizar novos derivados porfirínicos mesoglicosil substituídos e avaliar a eficácia destes compostos como PS na fotoinactivação de duas bactérias gram positivas ambientais, Brevibacterium sp. ...
Creative Peptides offers (6R,2S)-Diaminopimelic acid for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
Shop Osmoregulated proline transporter ELISA Kit, Recombinant Protein and Osmoregulated proline transporter Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Cystinuria is a health condition characterized by increased concentration of cystine and other dibasic amino acids in the urine. It most commonly occurs in young adults between the age of twenty and thirty years, although some individuals may present as children or in adolescence.
inproceedings{252737, author = {De Bruyn, Andr{\e} and Ikegami, F and Lambein, Fernand}, booktitle = {ARCHIVES INTERNATIONALES DE PHYSIOLOGIE, DE BIOCHIMIE ET DE BIOPHYSIQUE}, issn = {0778-3124}, language = {eng}, number = {6}, pages = {B72--B72}, title = {Conformation of the Lathyrus neurotoxin {\ss}-ODAP and its neurochemical implications}, volume = {102}, year = {1994 ...
[cliccare il link per andare alla versione in italiano] minestra di cicerchie Cicerchia (Lathyrus sativus) is a legume that, according to this page (in Italian), was once widely consumed, while nowadays, it is grown only in central Italy. before (bottom) and after soaking Cicerchie are available only dried: prior to cooking, they must be soaked for 24 hours and the soaking water must be eliminated because it contains a neurotoxic amino acid (ODAP or BOAA) that can cause lathyrism. This condition was and remains a problem when and where lack of alternative food sources led to consumption of large quantities of...
Trouver un emploi Guam avec Stages-Emplois, votre moteur de recherche emploi Guam, toutes les offres demploi Guam référencées pour trouver le job de vos rêves.
On Saturday, May 7, 2016 volunteers from the ECTA joined other community groups to plant 200 trees, and dedicate a bench to local champions Steve Revell, Bill Dinwoody, and Frank Smedley. Trees were planted in their honour at the Woolen Mills Conservation Area in Erin. Thank you to everyone who participated and supported the event.. ...
GenBank) UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase)(Meso-diaminopimelate-adding enzyme) (Meso-A2pm-adding enzyme) (UDP-N-acetylmuramyl-tripeptide synthetase) (UDP-MurNAc- ...
To develop radioimmunoassays (RIAS) for the measurement of the striped and white bass major reproductive hormones, the gonadotropins (GtH-I&II). To enable monitoring GtH levels in striped and white bass broodfish exposed to environmental or hormonal manipulations. To use a novel recombinant DNA approach for expressing immunoactive GtHs and for developing RIAs for fish gonadotropins.
Plants of Spain by Color - Pflanzen von Spanien nach Farbe - Plantas de Espa a por Color - V xter i Spanien efter f rg - Espanjan kasveja v rin mukaan
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer ...
Bayesian length-weight: a=0.00661 (0.00312 - 0.01398), b=3.01 (2.83 - 3.19), in cm Total Length, based on LWR estimates for this (Sub)family-body shape (Ref. 93245 ...
Lysinuric protein intolerance (LPI), also called hyperdibasic aminoaciduria type 2,cationic aminoaciduria or familial protein intolerance, is an autosomal recessive metabolic disorder affecting amino acid transport. About 140 patients have been reported, almost half of them of Finnish origin. Individuals from Japan, Italy, Morocco and North Africa have also been reported. Infants with LPI are usually symptom-free when breastfed because of the low protein concentration in human milk, but develop vomiting and diarrhea after weaning. The patients show failure to thrive, poor appetite, growth retardation, enlarged liver and spleen, prominent osteoporosis and osteopenia, delayed bone age and spontaneous protein aversion. Forced feeding of protein may lead to convulsions and coma. Mental development is normal if prolonged episode of hyperammonemia can be avoided. Some patients develop severe pulmonary and renal complications. High levels of plasma glutamine and glycine are observed. It has been ...
Sutherlandia frutescens. Sutherlandia frutescens is a popular traditional medicine and derives its common name, cancer bush from its long established (since 1895) use as a cancer tonic. Van Wyk and Albrecht16 currently are working on this plant.. Other uses of the plant include its use as an appetite stimulant (e.g. in persons with HIV/AIDS) and for the treatment of dysentry, kidney conditions, diabetes, internal cancers, liver conditions, uterine-related conditions, and stress and anxiety. The constituents of the plant are a high level of amino acids, canavanine (a non-protein amino acid), the cyclitol pinitol, a variety of flavonols, and triterpene glycosides (cycloartanes).. The published biological acitvities of these compounds confirm the traditional uses of the plant. A whole extract of Sutherlandia (as opposed to a single component), supports its continued use (maybe in a refined form) as a tonic by people with cancer or HIV/AIDS. The situation here is not unlike that of Pelargonium ...
Sutherlandia frutescens. Sutherlandia frutescens is a popular traditional medicine and derives its common name, cancer bush from its long established (since 1895) use as a cancer tonic. Van Wyk and Albrecht16 currently are working on this plant.. Other uses of the plant include its use as an appetite stimulant (e.g. in persons with HIV/AIDS) and for the treatment of dysentry, kidney conditions, diabetes, internal cancers, liver conditions, uterine-related conditions, and stress and anxiety. The constituents of the plant are a high level of amino acids, canavanine (a non-protein amino acid), the cyclitol pinitol, a variety of flavonols, and triterpene glycosides (cycloartanes).. The published biological acitvities of these compounds confirm the traditional uses of the plant. A whole extract of Sutherlandia (as opposed to a single component), supports its continued use (maybe in a refined form) as a tonic by people with cancer or HIV/AIDS. The situation here is not unlike that of Pelargonium ...
0028] Based on the results, it can reasonably be projected that soluble N.sup.α-long chain alkanoyl dibasic amino acid alkyl ester salts will provide synergistic anti-microbial activity when combined with a glycerol mono-fatty acid ester. It would seem that in order to obtain the practical benefits of the synergism between an N.sup.α-long chain alkanoyl dibasic amino acid alkyl ester salt and a glycerol mono-fatty acid ester, the solubility of the N.sup.α-long chain alkanoyl dibasic amino acid alkyl ester salt would need to be sufficient to release a concentration of N.sup.α-long chain alkanoyl dibasic amino acid alkyl ester cation which is greater than microbial inhibitory concentration of that ion in water at RT. Based on the data, it would seem that the absolute minimum solubility required would be approximately 5 ppm in water at RT. Desirably, however, the solubility of the N.sup.α-long chain alkanoyl dibasic amino acid alkyl ester salt should be such that the amount of cation released ...
Fotos/billeder af Planter, slægt Lathyrus: Forskelligbladet Fladbælg (Lathyrus heterophyllus), Klit-fladbælg (Lathyrus japonicus), Strand-Fladbælg (Lathyrus japonicus ssp. maritimus), Klit-Fladbælg (Lathyrus japonicus ssp. maritimus var. acutifolius), etc.
The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format. By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export. After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format. ...
My 4-month-old was diagnosed with MSPI (milk soy protein intolerance) at 1 month and my wife is nursing. We have tried the diet for three months now and have had varying degrees of success. The troubling thing is that after seeing our pediatrician almost every week until three months, and seeing a GI specialist, our daughter still has bloody stools. Im concerned about Crohns disease.
Lathyrus poisoning refers to the ingestion of one of the many types of legume plants within the Fabaceae family. Often, it refers directly to Lathyrus hirsutus, or the Caley pea. - Wag! (formerly Vetary)
In celebration of 25th anniversary of the Elora Cataract Trailway Association (ECTA), the Wellington County Museum and Archives newest exhibit Rails to Trails explores the stories of the development of the ECTA Trailway and the ...
Guam Holidays. Plan your stay in Guam around Guam holidays and find a current event in Guam. Learn about the best Guam festivals to plan your vacation to Guam.
Description and images of Lathyrus sp. #2496 (), a native Chilean plant, provided by the supplier of native exotic Chilean seeds and organizer of plant watching tours, Chileflora.com
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(PRESS RELEASE) -- Recently crowned PXC Bantamweight Champ, Michinori Tanaka of Japan, will defend his Title for the first time in hostile territory against rising MMA star from Guam, Kyle Aguon, on October 25th at the University of Guam Field House in Mangilao, Guam.
Situated in the heart of Mangilao overlooking beautiful Pago Bay, the University of Guam campus boasts a breathtaking ocean view, cool breezes, and modern, island-inspired architecture.
NIH Rare Diseases : 50 lysinuric protein intolerance is a metabolic disorder caused by the bodys inability to digest and use the amino acids lysine, arginine, and ornithine. because the body cannot effectively break down these amino acids, which are found in many protein-rich foods, individuals experience nausea and vomiting after ingesting protein. other features associated with protein intolerance may also occur, including short stature, muscle weakness, impaired immune function, and osteoporosis. a lung disorder called pulmonary alveolar proteinosis may develop in some individuals, as can end-stage renal disease, coma and intellectual disability. symptoms usually develop after infants are weaned and begin to eat solid foods. lysinuric protein intolerance is caused by mutations in the slc7a7 gene. it is inherited in an autosomal recessive manner. last updated: 11/15/2010 ...
Lysinuric protein intolerance (LPI) is a rare autosomal recessive inborn error of metabolism, characterised by defective transport of the cationic amino acids lysine, arginine and ornithine. To date there are few reported necropsy cases. This report describes the necropsy findings in a 21 year old female patient originally diagnosed as having LPI in 1973. Liver function tests deteriorated and immediately before death jaundice, hyperammonaemia, coma, metabolic acidosis, and a severe bleeding diathesis developed. At necropsy, there was micronodular cirrhosis of the liver with extensive fatty change in hepatocytes. The lungs showed pulmonary alveolar proteinosis. Immunofluorescence and electron microscopy revealed the presence of a glomerulonephritis with predominant IgA deposition. These necropsy findings reflect the spectrum of lesions reported in LPI, providing further evidence of an association between this condition and pulmonary alveolar proteinosis, cirrhosis and glomerulonephritis.. ...
More than 40 mutations in the SLC7A7 gene have been found to cause lysinuric protein intolerance. All of these mutations impair the y+LAT-1 proteins ability to transport amino acids. People with lysinuric protein intolerance who are of Finnish descent typically have the same mutation. This mutation (written as IVS6-2A,T) disrupts the way the genes instructions are used to make the y+LAT-1 protein, causing the protein to be misplaced in the cell.. Mutations in the y+LAT-1 protein disrupt the transportation of amino acids, leading to a shortage of lysine, arginine, and ornithine in the body and an abnormally large amount of these amino acids in urine. The abnormal transportation and shortage of these amino acids in various tissues of the body leads to the signs and symptoms of lysinuric protein intolerance. ...
Cystinuria is defined as an inherited disorder characterized by increased urinary excretion of cystine and the dibasic amino acids arginine, lysine and ornithine. The only clinical manifestation of cystinuria is renal cystine stone formation due to the low solubility of cystine in the urine. Cystinuria can be attributed to mutations in the SLC3A1 and SLC7A9 genes in the majority of all cases and it has been a common expectation that molecular genetic studies of cystinuria would aid in understanding of the varying clinical outcome seen in the disease. Besides human, the disease has been most extensively studied in the domestic dog.. The present study was undertaken to investigate the molecular genetic basis of cystinuria in patients from Sweden and to correlate genetic findings with phenotypes produced regarding cystine and dibasic amino acid excretion. Further, attempts were made to elucidate the molecular genetics of cystinuria in the dog.. The entire coding sequences of the SLC3A1 and SLC7A9 ...
The genus Brevibacterium (phylum, Actinobac-teria) are described as non-motile, non-sporing, non-acid-fast, irregular-shaped organisms that belong to the coryneform group. Like other coryneform bacteria, Brevibacterium sp. are Gram positive rods, but both their staining pattern and shape can vary, depending on the age and condition of the cells. They also are high G+C organisms (60 to 67 mol%). Brevibac-terium are strictly aerobic, catalase-positive mesophiles, with an optimum growth temperatures between 20°C and 35°C. Most species are salt-tolerant (,10%) and able to grow over a wide pH range.There are currently eighteen recognized species; the phylogeny of twelve representative species is shown in Figure 2-8.. Several are of medical importance and have been considered as opportunistic pathogens. One species, Brevibacterium linens, is important in fermented foods, mainly because it is involved in the manufacture of bacterial, surface-ripened cheeses, such as Limburger and Muenster. In these ...
Personal Care & Cosmetics (Protectants) | Personal Care & Cosmetics formulations, data sheets, MSDS search, specifications and request samples all in one location - Free Access.
Personal Care & Cosmetics (Protectants) | Personal Care & Cosmetics formulations, data sheets, MSDS search, specifications and request samples all in one location - Free Access.
In a follow-up experiment, they selected 39 of those mussels that had previously served as "blood donors"and exposed each to one of twelve H. elongata clones that were used in the in vitro experiment and found that the results of the in vitro experiment were pretty good indicators of the outcome of those experimental exposures - mussels with blood that killed all the H. elongata they came in contact with were also better than most at fighting off infection by the parasitic fluke. The rest of the mussels were fairly vulnerable to H. elongata and a small handful offered almost no resistance. The larger mussels were generally better at fighting off the parasites with just a little over a quarter of the H. elongata cercariae getting through, while more than half of the cercariae successfully established in the smaller mussels, regardless of the host or parasite genotype ...
The first cystine stone was identified in 1810 by Wollaston, who called it cystic oxide.65 Cystinuria is an autosomal recessive disease characterised by renal and intestinal dibasic amino acid transport defects affecting cystine, ornithine, arginine, and lysine, of which cystine is the least soluble and therefore the most likely to precipitate as a stone.66 Cystinuria type I has now been shown to be caused by a mutation in the gene SLC3AI, which encodes the rBAT protein.67 The M467T mutation appears to be particularly important, but there are several other minor variants that may also be relevant.68 Regardless of cause, the primary goal of medical management is to prevent the formation of new stones by reducing the cystine concentration to below its upper limit of solubility. The precise solubility limits are unclear, with a variety of possibilities cited: urine solubility of 250 mg/litre (200 μmol/litre) at pH 5.0, rising to 500 mg/litre (410 μmol/litre) at pH 7.5, and 1000 mg/litre (820 ...
The flowers can be eaten raw or cooked, and add a colorful garnish to salads and other foods. The tips of the vines and the young shoots, leaves, and tendrils can be eaten cooked. The most nutritious part of the plant, the pods and their seeds, can technically be eaten raw (though theyre usually tough) and are best cooked. Fried in butter with a splash of vinegar and lemon juice and topped with parmesan is the best way to go, but in case youre in a survival situation theyre still quite tasty plain. The roots of one species, Lathyrus tuberosus, grow tubers which can be eaten cooked.. And, as usual, make sure not to subsist entirely off of these just to be safe. Happy foraging!. div.wpmrec2x{max-width:610px;} div.wpmrec2x div.u > div{float:left;margin-right:10px;} div.wpmrec2x div.u > div:nth-child(3n){margin-right:0px;} ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cyanobacterial β-N-methylamino-L-alanine (BMAA) has been suggested as a causative or contributory factor in the development of several neurodegenerative diseases. However, no BMAA animal model has adequately shown clinical or behavioral symptoms that correspond to those seen in either Alzheimers Disease (AD), Amyotrophic Lateral Sclerosis (ALS) or Parkinsons Disease (PD). We present here the first data that show that when neonatal rats were exposed to BMAA on postnatal days 3, 4 and 5, but not on gestational day 14 or postnatally on days 7 or 10, several AD and/or PD-related behavioral, locomotor and cognitive deficits developed ...
Reviews of vegetarian restaurant Simply Food in Guam, Micronesia Loaded up on grocery items that I didnt think I would be able to find on Guam. While some items seem really pricey (hey- its Guam, after all!) there were things that were
redescription Cho, K.H., W.-S. Kim, R. Böttger-Schnack, R. & W. Lee. (2013). A new species of the dentipes-subgroup of Triconia and a redescription of T. giesbrechti and T. elongata (Copepoda: Cyclopoida: Oncaeidae) from the tropical Pacific and the Korea Strait. Journal of Natural History, Vol. 47, Nos. 25-28, 1707-1743., available online at https://doi.org/10.1080/00222933.2013.771757 [details] ...
1LOA: Three-dimensional structures of complexes of Lathyrus ochrus isolectin I with glucose and mannose: fine specificity of the monosaccharide-binding site.
For vascular plants occurring in wildlands or otherwise outside of cultivation in California, the Jepson eFlora contains taxonomic treatments, distribution maps, illustrations, photographs, and identification keys.
Höjd: 100 cm. Färg: Ljusrosa. Blomtid: Juli-September. Läge: Sol-Halvskugga. Växtsätt: Klättrande. Förökning: Görs enklast genom att dela planta eller frösådd. Fröerna måste statifieras.. ...
Wild peas in the Lathyrus genus, are often described as toxic. Well, thats not exactly true. Here is some science behind eating wild peas.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
For the first time, an entire publication has been dedicated to providing a critical review of the identification and analysis of the milk specific proteins
Armani Arrives in Style Among the Top Five LPI Ayrshire Sires, tied at #5 LPI, and also captures #3 Milk, tied #8 Fat, #6 Protein with +7 Conformation.
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LPI is an autosomally recessively inherited amino acid disorder due to defective transport of cationic amino acids lysine, arginine and ornithine in the intestine and kidney tubules. The absence or dysfunction of the transport process leads to low plasma and high urine concentration of the cationic (dibasic) amino acids. Clinical presentation of the disease usually takes place during the weaning period when breast feeding is replaced by cows milk and other high protein diets. Nausea, vomiting and mild diarrhea usually are the first symptoms followed by failure to thrive and growth retardation. Later liver and spleen become enlarged, muscles are hypotonic and osteoporosis can cause bone fractures. High protein intake can lead to hyperammonemia and even to coma, possibly accounting for the mild intellectual deficit found in few cases of LPI. Many patients have spontaneously developed aversion to protein rich food. A pulmonary complication of unknown mechanism, alveolar proteinosis has occurred in few
PAP in LPI is often untreatable and results in death. In this study, we carefully characterized BALF and tissue samples obtained from an LPI patient. The data revealed elevated levels of protein and dying cells in the airways. In addition, large cholesterol crystals and abnormal tubular myelin structures were found. Our primary cell culture assays using Alexa-647 conjugated BSA and apoptotic Jurkat T cells showed that pre-incubation of the LPI BAL cells with SP-D and GM-CSF increased their innate immune functions. Surprisingly, many of these LPI cells, but not the control cells, became elongated and stopped internalizing foreign material; eventually they formed granulomas ex vivo. Notably, treating these cells with GM-CSF ex vivo dramatically increased granuloma formation. However, treating the cells with SP-D reduced GM-CSF-mediated granuloma formation. Therefore, these findings may provide important clues for devising better treatment of PAP in LPI patients.. Although various SLC7A7 mutations ...
Think your baby has milk protein intolerance? Seek timely diagnosis, like exclusion diet and take measures, like switch formula, to keep your baby on the safe side.
Looking for online definition of paired basic amino acid cleaving enzyme in the Medical Dictionary? paired basic amino acid cleaving enzyme explanation free. What is paired basic amino acid cleaving enzyme? Meaning of paired basic amino acid cleaving enzyme medical term. What does paired basic amino acid cleaving enzyme mean?
APG IV Classification: Domain: Eukaryota • (unranked): Archaeplastida • Regnum: Plantae • Cladus: angiosperms • Cladus: eudicots • Cladus: core eudicots • Cladus: superrosids • Cladus: rosids • Cladus: eurosids I • Ordo: Fabales • Familia: Fabaceae • Genus: Lathyrus • Species: Lathyrus pauciflorus Fernald ...
Looking for basic amino acid as? Find out information about basic amino acid as. any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur. These compounds are the building... Explanation of basic amino acid as
La putrescina carbammiltransferasi è un enzima appartenente alla classe delle transferasi, che catalizza la seguente reazione: carbammilfosfato + putrescina ⇄ fosfato + N-carbammilputrescina Lenzima contenuto nelle piante catalizza anche la reazione tipica della ornitina carbammiltransferasi (numero EC 2.1.3.3), della carbammato chinasi (numero EC 2.7.2.2) e della agmatina deiminasi (numero EC 3.5.3.12), che dunque agisce come putrescina sintasi, convertendo rispettivamente lagmatina e lornitina in putrescina e citrullina. ^ (EN) 2.1.3.3, in ExplorEnz - The Enzyme Database, IUBMB. ^ (EN) 2.7.2.2, in ExplorEnz - The Enzyme Database, IUBMB. ^ (EN) 3.5.3.12, in ExplorEnz - The Enzyme Database, IUBMB. Srivenugopal, K.S. and Adiga, P.R., Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase), in J. Biol. Chem., vol. 256, 1981, pp. 9532-9541, Entrez PubMed 6895223. Roon, R.J. and Barker, H.A., ...
Breast feeding is the most nutritious form of nourishment in infants and is recommended for at least the first four months of life. Breast fed infants may develop milk protein intolerance. The management of breast milk protein intolerance differs from that of cows milk protein intolerance in formula fed infants. Because breast milk is considered by many to be nutritionally superior to formula and results in maternal infant bonding mothers are often told to continue breast feeding. Despite the lack of evidence based data to support or refute the modification of the mothers diet, it is suggested that they eliminate their own intake of dairy products strictly and avoid supplementing with a cows milk based formula. We are doing this study because we believe that deletion of dairy from the diet of a breast feeding mother will not cause BMPI to resolve ...
Mapped cpDNA restriction site characters were analyzed cladistically and the resulting phylogenetic hypotheses were used to test monophyly and relationships of the infrageneric classification of Lathyrus (Fabaceae) proposed by Kupicha (1983, Notes from the Royal Botanic Garden Edinburgh 41: 209-244). The validity of previously proposed classification systems and questions presented by these classification schemes were explored. Two cpDNA regions, rpoC (rpoC1, its intron, part of rpoC2, and their intergenic spacer) and IR- (psbA, trnH-GUG, part of ndhF, and their intergenic spacers), were analyzed for 42 Lathyrus and two Vicia species. PCR (polymerase chain reaction) amplified rpoC and IR- products digested with 31 and 27 restriction endonucleases, respectively, resulted in 109 potentially informative characters. The strict consensus tree suggests that several of Kupichas sections may be combined in order to constitute clades. The widespread section Orobus and the South American section ...
Cystinuria is a disease of disrupted amino acid transport in the collecting ducts of the kidney failing to reclaim certain amino acids (cystine and the dibasic amino acids ornithine, lysine and arginine referred to as COLA). The increased urinary COLA concentrations reach saturation levels for cystine, which precipitates to form crystals and stones resulting in renal to urethral obstructions. Mutations in the SLC3A1 and SLC7A9 genes give rise to cystinuria in the vast majority of cystinuric humans, where the disease shows autosomal recessive or dominant inheritance (reviewed in Palacin et al. 2001; Chillaron et al. 2010).. Cystine calculi have been reported from at least 70 dog breeds, with increased incidence in several breeds (Ling et al. 1998; Osborne et al. 1999); in contrast, cystinuria is rarely seen in cats. We previously demonstrated autosomal recessively inherited cystinuria in Newfoundland dogs (with less frequent urolithiasis in females due to anatomical urological differences) caused ...

CNH Technologies, Inc. | Diamino-Amino AcidsCNH Technologies, Inc. | Diamino-Amino Acids

Diamino-Amino Acids. 7 Results Catalog #. Product Name. CAS. Structure. E-6010. Nα-Boc-(+-)-2,3-diaminopropionic acid. 159002- ... Nα-Boc-(S)-2-amino-3-(dimethylamino)propionic acid. 94778-71-9. ... Nα-Boc-(S)-2-amino-6-(dimethylamino)hexanoic acid. 65671-53-6. ... Nα-Boc-(R)-2-amino-3-(dimethylamino)propionic acid. 110755-32-3. ... Nα-Boc-(+-)-2-amino-3-(dimethylamino)propionic acid. 851653-36-6. ...
more infohttp://cnhtechnologies.com/products/6/Diamino-Amino-Acids

2-[(1,2-Diamino-2-iminoethylidene)amino]acetic acid | C4H8N4O2 - PubChem2-[(1,2-Diamino-2-iminoethylidene)amino]acetic acid | C4H8N4O2 - PubChem

... amino]acetic acid , C4H8N4O2 , CID 10654325 - structure, chemical names, physical and chemical properties, classification, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/010654325

IUCr) 2,3-Di-amino-pyridinium sorbate-sorbic acid (1/1)IUCr) 2,3-Di-amino-pyridinium sorbate-sorbic acid (1/1)

In the title mol-ecular salt-adduct, C5H8N3+·C6H7O2−·C6H8O2, the 2,3-diamino-pyridinium cation is essentially planar, with a ... For background to amino-pyridines, see: Peng et al. (2001. ); Leung et al. (2002. ); Banerjee & Murugavel (2004. ); Lautie & ... The carboxyl groups of the sorbic acid mol-ecules and the carboxyl-ate groups of the sorbate anions are connected via O-H⋯O ... In the crystal, the protonated N atom and one of the two amino-group H atoms are hydrogen bonded to the sorbate anion through a ...
more infohttp://journals.iucr.org/e/issues/2012/01/00/hb6558/index.html

2-[[4-[(2,6-Diamino-7H-purin-8-yl)methylamino]benzoyl]amino]pentanedioic Acid | C18H20N8O5 - PubChem2-[[4-[(2,6-Diamino-7H-purin-8-yl)methylamino]benzoyl]amino]pentanedioic Acid | C18H20N8O5 - PubChem

... amino]pentanedioic Acid , C18H20N8O5 , CID 4017565 - structure, chemical names, physical and chemical properties, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/4017565

CAS # 59-05-2, Methotrexate, (+)-Amethopterin, (+)-4-Amino-10-methylfolic acid, N-(p-(((2,4-Diamino-6-pteridinyl)methyl...CAS # 59-05-2, Methotrexate, (+)-Amethopterin, (+)-4-Amino-10-methylfolic acid, N-(p-(((2,4-Diamino-6-pteridinyl)methyl...

4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid, molecular formula: C20H22N8O5. ... Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid. ...
more infohttps://www.chemblink.com/products/59-05-2.htm

Differential laser-induced perturbation Raman spectroscopy: a comparison with Raman spectroscopy for analysis and...Differential laser-induced perturbation Raman spectroscopy: a comparison with Raman spectroscopy for analysis and...

A. P. Mendham et al., "Vibrational spectroscopy and DFT calculations of Di-amino acid cyclic peptides. Part I: Cyclo(Gly-Gly), ... Amino acid solutions were created by separately dissolving the three amino acids l-proline (17.3 mM), purchased from Fluka, and ... Average Raman and DLIPS spectra of amino acids and dipeptides. (a) l-alanine. (b) Glycine. (c) l-proline. (d) Ala-Gly. (e) Gly- ... It is shown that the use of low-intensity UV laser light for perturbation of the amino acid and dipeptide molecular structures ...
more infohttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-20/issue-04/047006/Differential-laser-induced-perturbation-Raman-spectroscopy--a-comparison-with/10.1117/1.JBO.20.4.047006.full?SSO=1

RCSB PDB - AHB Ligand Summary PageRCSB PDB - AHB Ligand Summary Page

... nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to ... Amino Acids, Basic. *Amino Acids, Diamino. *Amino Acids, Neutral. *Amino Acids, Peptides, and Proteins ... Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. , PMID:21059682 ...
more infohttps://www.rcsb.org/ligand/AHB

Chemical Database: L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-, sodium salt ...Chemical Database: L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-, sodium salt ...

4-diamino-6-pteridinyl)methyl)amino)benzoyl)-, sodium salt including: 2 synonyms/identifiers. ... This page contains information on the chemical L-Glutamic acid, N-(4-(((2, ... L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl) methyl) amino) benzoyl)-, sodium salt. Identifications. *CAS Number: 31823- ... L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl) methyl) amino) benzoyl)-, sodium salt Related Resources. *USDOT Hazardous ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/L-Glutamic%A0acid%2C%A0N-%284-%28%28%282%2C4-diamino-6-pteridinyl%29methyl%29amino%29benzoyl%29-%2C%A0sodium%A0salt.html

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-,, CAS Number: 54-62-6L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-,, CAS Number: 54-62-6

4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, - chemical information, properties, structures, articles, patents and more ... amino]pentanedioic acid, 4-Amino-4-deoxypteroylglutamate, 4-Aminofolic acid, 4-Amino-PGA, 4-Aminopteroylglutamic acid, 4- ... Folic acid, 4-amino-, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-, KBio1_001939, KBio2_002391, ... amino]glutaric acid, 2-[[4-[(2,4-diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid, … ...
more infohttp://www.chemindustry.com/chemicals/053676.html

Prof Simon J Coles | Chemistry | University of SouthamptonProf Simon J Coles | Chemistry | University of Southampton

X-ray crystallographic structure of the cyclic Di-amino acid peptide: N,N?-diacetyl-cyclo(Gly-Gly). Journal of Chemical ... X-ray crystallographic structure and absolute configuration of the cyclic Di-amino acid peptide: cyclo(l-HomoCySH-l-HomoCySH). ... Chio, F. K., Warne, J., Gough, D., Penny, M., Green, S., Coles, S. J., ... Dobbs, A. P. (2011). On the choice of Lewis acids ... Lynch, D. E., McClenaghan, I., Light, M. E., & Coles, S. J. (2002). The hydrogen-bonding networks of 2-amino-4-phenyl-1,3- ...
more infohttps://www.southampton.ac.uk/chemistry/about/staff/sjc5.page

chemistry of proteins.ppt | Amino Acid | Proteinschemistry of proteins.ppt | Amino Acid | Proteins

... mono-amino, monocarboxylic).. 2. - Acidic amino acids (mono-amino,. dicarboxylic).. 3. - Basic amino acids (diamino, ... amino groups). Amino acids can be classified into:. a) Neutral amino acids.. b) Acidic amino acids.. c) Basic amino acids. ... All these amino acids are alpha-amino acids and. the metabolizible form of them are L-amino acids.. Alpha-amino acid means that ... amino acids may be classified into:. A- Essential amino acids: These are amino. acids that can not be synthesized in the. human ...
more infohttps://de.scribd.com/presentation/337321334/chemistry-of-proteins-ppt

Common Chemistry - Substance Details - 54-62-6 : L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]Common Chemistry - Substance Details - 54-62-6 : L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]

Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-, L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl) ... methyl]amino]benzoyl]-, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, N-[4-[[(2,4-Diamino-6- ... amino]benzoyl]-, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Acide N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L ... acido N-[4-[[(2,4-diamino-6-pteridinil)metil]amino]benzoil]-L-glutamico, Aminopterin, AMINOPTERIN, Aminopterine, APGA, ...
more infohttp://www.commonchemistry.org/ChemicalDetail.aspx?ref=54-62-6

Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha...Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha...

... beta-diaminopropionic acid. Article date: 1988/1/19 PubMed ID: 2895006 Journal name: European journal of pharmacology (ISSN: ... alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha, ... Amino Acids, Diamino, Receptors, Drug, Receptors, AMPA, Receptors, Kainic Acid, oxalyldiaminopropionic acid, Oxadiazoles, ... alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Mesh terms: Amino Acids, Diamino/pharmacology; Animals; Brain; ...
more infohttps://muscimol.xyz/2895006

Chirality, photochemistry and the detection of amino acids in interstellar ice analogues and comets - Chemical Society Reviews ...Chirality, photochemistry and the detection of amino acids in interstellar ice analogues and comets - Chemical Society Reviews ...

The primordial appearance of chiral amino acids was an essential component of the asymmetric evolution of life on Earth. In ... amino acids. and elucidate current experimental data. on the photochemical synthesis of amino. and diamino acid structures in ... amino acids. in interstellar ice analogues and comets Amanda C. Evans,a Cornelia Meinert,b Chaitanya Giri,bc Fred Goesmannc and ... amino acids. in interstellar ice analogues and comets A. C. Evans, C. Meinert, C. Giri, F. Goesmann and U. J. Meierhenrich, ...
more infohttps://pubs.rsc.org/en/content/articlelanding/2012/cs/c2cs35051c

Methods and compositions for F-18 labeling of proteins, peptides and other molecules - Immunomedics, Inc.Methods and compositions for F-18 labeling of proteins, peptides and other molecules - Immunomedics, Inc.

Groups were added to the side chains of diamino amino acids by using Fmoc/Aloc protecting groups to allow differential ... An "amino acid" may be an L-amino acid, a D-amino acid, an amino acid analogue, an amino acid derivative or an amino acid ... The targetable construct may also comprise unnatural amino acids, e.g., D-amino acids, in the backbone structure to increase ... Peptide stabilization may also occur by substitution of D-amino acids for naturally occurring L-amino acids, particularly at ...
more infohttp://www.freepatentsonline.com/7563433.html

The Cyclisation Occurring Through The 4-amino Radical Of 2,4-diamino Butanoic Acid Patents and Patent Applications (Class 530...The Cyclisation Occurring Through The 4-amino Radical Of 2,4-diamino Butanoic Acid Patents and Patent Applications (Class 530...

4-diamino Butanoic Acid Patents and Patent Applications (Class 530/318) Filed with the USPTO ... Search for The Cyclisation Occurring Through The 4-amino Radical Of 2, ... 4-diamino Butanoic Acid Patents (Class 530/318) The Cyclisation Occurring Through The 4-amino Radical Of 2,4-diamino Butanoic ... the side-chain carboxy terminus of one amino acid in the peptide chain to the side-chain amino terminus of another amino acid ...
more infohttps://patents.justia.com/patents-by-us-classification/530/318

Glossary of Research Terms - MS Society of CanadaGlossary of Research Terms - MS Society of Canada

The chain can be two (di-) amino acids, three (tri-) amino acids, or more (poly-) amino acids in length.. Peripheral nervous ... Peptide - A chain of amino acid building blocks strung together. ... Deoxyribonucleic acid (DNA) - The code of genetic instructions ... A term describing the ability of molecules, such as fats, fatty acids and soaps, to dissolve in fat.. Lymphocytes - White blood ... DNA is shaped as a double helix and is made up of nucleic acid-sugar complexes loosely bound to proteins. ...
more infohttps://mssociety.ca/about-ms-research/glossary-of-research-terms

Intravenous L-citrulline - Asklepion - AdisInsightIntravenous L-citrulline - Asklepion - AdisInsight

Asklepion is developing intravenous formulation of L-citrulline a non-essential amino acid, for prevention of acute post- ... Class Amino acids; Diamino amino acids * Mechanism of Action Amino acid replacements ...
more infohttp://adisinsight.springer.com/drugs/800047917?error=cookies_not_supported&code=d8defe9e-d427-4ae0-a04a-31ee2074a5aa

Water stress and accumulation of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in grass pea (Lathyrus sativus) | MetaWater stress and accumulation of beta-N-oxalyl-L-alpha,beta-diaminopropionic acid in grass pea (Lathyrus sativus) | Meta

Determination of neurotoxin 3-N-oxalyl-2,3-diaminopropionic acid and non-protein amino acids in Lathyrus sativus by precolumn ... Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy ... Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid β-ODAP (β-N-oxalyl-L-α,β- ... Effect of environmental factors on the biosynthesis of the neuro-excitatory amino acid β-ODAP (β-N-oxalyl-L-α,β- ...
more infohttps://www.meta.org/papers/water-stress-and-accumulation-of-beta-n-oxalyl-l-a/11170580

Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies<...Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies<...

Urine was collected in metabolic cage experiments to quantify amino acids in DP-treated and nontreated, nonlithiasic mutant ... Urine was collected in metabolic cage experiments to quantify amino acids in DP-treated and nontreated, nonlithiasic mutant ... Urine was collected in metabolic cage experiments to quantify amino acids in DP-treated and nontreated, nonlithiasic mutant ... Urine was collected in metabolic cage experiments to quantify amino acids in DP-treated and nontreated, nonlithiasic mutant ...
more infohttps://qfrd.pure.elsevier.com/en/publications/slc7a9-knockout-mouse-is-a-good-cystinuria-model-for-antilithiasi

Formation and Chiroptical Properties of Amino Acids in Interstellar Ice AnaloguesFormation and Chiroptical Properties of Amino Acids in Interstellar Ice Analogues

... on the formation of amino acids and diamino acids under interstellar conditions and on chiroptical properties of amino acids in ... to the amino acids and diamino acids identified in meteorites (3) and will be discussed in the context of the molecular origin ... chromatographic and mass spectrometric analysis allowing us the identification of 16 different amino acids and diamino acids (2 ... In a UHV-chamber we deposited amorphous amino acid films of defined thickness on MgF2 windows (see Figure) and subjected them ...
more infohttps://www.jbsdonline.com/c4306/formation-and-chiroptical-properties-amino-acids-interstellar-ice-analogues-p17917.html

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Amino acid transport systems, Amino acids diamino, Mutation, Sulphydryl compounds, urine, Cystine, Carrier proteins, Cystinuria ... The genetic basis of the disorder is best characterized in humans and is caused by mutations in one of the amino acid ... which results in hyperexcretion of cystine and the dibasic amino acids in the urine and subsequent precipitation of cystine due ... in French and English Bulldogs that affect nonconserved amino acid residues, arguing against functional impact on the proteins ...
more infohttp://liu.diva-portal.org/smash/record.jsf?pid=diva2%3A17216

Efflux of Amino Acids from the Lens | IOVS | ARVO JournalsEfflux of Amino Acids from the Lens | IOVS | ARVO Journals

... competing diamino acids compared with the neutral amino acids. ... Amino Acid Transport in the Lens. Amino Acid Transport in the ... Efflux of Amino Acids from the Lens You will receive an email whenever this article is corrected, updated, or cited in the ... The two neutral amino acids examined had rate coefficients for efflux which were similar, and approximately equal to rate ... Role of a Dual Splicing and Amino Acid Code in Myopia, Cone Dysfunction and Cone Dystrophy Associated with L/M Opsin ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2128669
  • 14 The proximal tubules, but not distal segments of the nephron, are endowed with high aromatic l -amino acid decarboxylase (AADC) activity, and epithelial cells of proximal tubules have been demonstrated to synthesize dopamine from circulating or filtered l -3,4-dihydroxyphenylalanine ( l -DOPA). (ahajournals.org)
  • In the crystal, the protonated N atom and one of the two amino-group H atoms are hydrogen bonded to the sorbate anion through a pair of N-H⋯O hydrogen bonds, forming an R 1 2 (6) ring motif. (iucr.org)
  • Urine was collected in metabolic cage experiments to quantify amino acids in DP-treated and nontreated, nonlithiasic mutant mice. (elsevier.com)
  • The genetic basis of the disorder is best characterized in humans and is caused by mutations in one of the amino acid transporter genes SLC3A1 or SLC7A9 , which results in hyperexcretion of cystine and the dibasic amino acids in the urine and subsequent precipitation of cystine due to its low solubility in urine. (diva-portal.org)
  • Mild acid treatment readily removes the N-sulfinyl group in the sulfinamide products affording the free amine derivatives. (wikipedia.org)
  • 1. Essential amino acids: Not synthesized in the body and must be supplied in the diet. (scribd.com)
  • 2. Non-essential amino acids: Can be synthesized in the body and is not essential to be present in diet. (scribd.com)
  • The present study was undertaken to investigate the molecular genetic basis of cystinuria in patients from Sweden and to correlate genetic findings with phenotypes produced regarding cystine and dibasic amino acid excretion. (diva-portal.org)
  • This is because the polypeptides are too large to enter the bloodstream, and so they must be broken down into their smaller groups of amino acids and absorbed that way (the same is true for protein you eat from food sources). (priceplow.com)
  • The chemical and physical properties of a protein cannot be fully interpreted until all three levels of structure are understood, for these properties depend on the spatial relationships between the amino-acids, and these in turn depend on the tertiary and secondary structures as much as on the primary. (todayinsci.com)
  • In the title mol-ecular salt-adduct, C 5 H 8 N 3 + ·C 6 H 7 O 2 − ·C 6 H 8 O 2 , the 2,3-diamino-pyridinium cation is essentially planar, with a maximum deviation of 0.013 (2) Å, and is protanated at its pyridine N atom. (iucr.org)
  • The differential absorption of circularly polarized light by individual amino acid enantiomers, which determines speed and intensity of enantioselective photolysis, was recorded in the vacuum-ultraviolet spectral range, where massive circular dichroic transitions were observed (5). (jbsdonline.com)