Amino Acids
Sequence Homology, Amino Acid
Amino Acid Sequence
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Cloning, Molecular
Amino Acids, Essential
Amino Acid Transport Systems
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Base Sequence
Amino Acid Motifs
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Mutation
Binding Sites
Mutagenesis, Site-Directed
DNA, Complementary
Sequence Homology, Nucleic Acid
Peptide Fragments
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Models, Molecular
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Structure-Activity Relationship
Protein Binding
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Substrate Specificity
Restriction Mapping
Recombinant Fusion Proteins
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Sequence Analysis, DNA
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Electrophoresis, Polyacrylamide Gel
Alanine
Protein Structure, Secondary
Amino Acid Transport Systems, Basic
Plasmids
Conserved Sequence
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
DNA Primers
Chromatography, High Pressure Liquid
Isoleucine
Carrier Proteins
Cattle
Codon
A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).
Trypsin
Biological Transport
Cyanogen Bromide
Glycine
Genes
Open Reading Frames
Protein Biosynthesis
Glutamine
Saccharomyces cerevisiae
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Gene Library
Valine
Transcription, Genetic
Sequence Analysis
Excitatory Amino Acids
Aspartic Acid
Mutagenesis
Transfection
Proline
Point Mutation
Nitrogen
Phenylalanine
Membrane Proteins
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Amino Acid Transport System A
Gene Expression
Blotting, Northern
Macromolecular Substances
Evolution, Molecular
Plant Proteins
DNA-Binding Proteins
Sequence Analysis, Protein
Rabbits
Chromatography, Gel
Threonine
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
COS Cells
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Liver
Chromatography, Ion Exchange
Transcription Factors
Cell Membrane
Endopeptidases
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Protein Sorting Signals
Receptors, Amino Acid
Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition.
Chymotrypsin
Dietary Proteins
Cricetinae
Chickens
Serine
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Cells, Cultured
Catalysis
Repetitive Sequences, Amino Acid
Peptide Mapping
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Genetic Complementation Test
Hydrogen-Ion Concentration
Temperature
Glutamic Acid
Blotting, Southern
Aminoisobutyric Acids
Amino Acyl-tRNA Synthetases
Circular Dichroism
Chromosome Mapping
Phenotype
Carbon Isotopes
Oligodeoxyribonucleotides
Serine Endopeptidases
Oligonucleotide Probes
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
Enzyme Stability
Mass Spectrometry
Magnetic Resonance Spectroscopy
Tyrosine
Cystine
Large Neutral Amino Acid-Transporter 1
Exons
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Phosphorylation
Molecular Structure
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Carbohydrates
Sequence Homology
Chemistry
HeLa Cells
Cercopithecus aethiops
Crystallography, X-Ray
Asparagine
RNA
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Isoenzymes
Saccharomyces cerevisiae Proteins
Stereoisomerism
Genetic Code
Dimerization
Chemical Phenomena
Consensus Sequence
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Models, Biological
Caseins
Plants
Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.
Mutation, Missense
Chromatography, Affinity
Gene Expression Regulation
Catalytic Domain
Glycosylation
Binding, Competitive
CHO Cells
Glycoproteins
Xenopus laevis
DNA Restriction Enzymes
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Biological Evolution
Fibroblast Growth Factor 2
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Gene Expression Regulation, Bacterial
Carboxypeptidases
Solubility
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Cytoplasm
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Protein Engineering
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Transaminases
Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. (1/107)
Autoantibodies directed against spliceosomal proteins are a common and specific feature of systemic lupus erythematosus. These autoantibodies target a collection of proteins, including Sm B, B', D1, D2, and D3. We define the common antigenic targets of Sm D2 and D3 and examine their role in spliceosomal autoimmunity. Our results define nine major common epitopes, five on Sm D2 and four on Sm D3. These epitopes have significantly higher (more basic) isoelectric points than do nonantigenic regions. In fact, this association is of sufficient power to make isoelectric point an excellent predictor of spliceosomal antigenicity. The crystallographic structure of Sm D2 and D3 is now partially described. The anti-Sm D2 and D3 antigenic targets are located on the surface of the respective three-dimensional complexed proteins, thereby suggesting that these epitopes are accessible in the native configuration. All but one of these nine epitopes conspicuously avoid the specific regions involved in intermolecular interactions within the spliceosomal complex. One of the D3 epitopes (RGRGRGMGR) has significant sequence homology with a major antigenic region of Sm D1 (containing a carboxyl-terminal glycine-arginine repeat), and anti-D3 Abs cross-react with this epitope of Sm D1. These results demonstrate that spliceosomal targets of autoimmunity are accessible on native structure surfaces and that cross-reactive epitopes, as well as structural associations of various spliceosomal Ags, may be involved in the induction of autoimmunity in systemic lupus. (+info)Membrane activity of the southern cowpea mosaic virus coat protein: the role of basic amino acids, helix-forming potential, and lipid composition. (2/107)
Southern cowpea mosaic virus (SCPMV) is a spherical RNA virus with T = 3 icosahedral symmetry. The particle is composed of 180 subunits of the coat protein (CP) and one copy of the positive-sense viral RNA. The CP has two domains, the random (R) domain formed by the N-terminal 64 aa and the shell (S) domain (aa 65--260). The R domain is highly charged, with 11 of the N-terminal 30 residues being basic. It is localized to the interior of the native particle where it may interact with the viral RNA, but under certain pH and salt conditions the topology of the particle changes to externalize the R domain. Since the CPs of several spherical RNA viruses have been shown to interact with host membranes during infection, we have begun investigating the membrane interactions of the SCPMV CP using the artificial liposome membranes. Both the native CP and the R domain overexpressed in Escherichia coli were observed to interact with liposomes. The interaction between the R domain and liposomes required either anionic phospholipids or non-bilayer-forming lipids and involved electrostatic interactions since it was shown to be both pH and ionic strength dependent. The analysis of four different deletion and six different site-directed substitution mutations partially mapped the region responsible for this interaction to residues 1--30. Analysis of this region of the R domain by circular dichroism indicated that it assumes an alpha-helical structure when exposed to liposomes composed of anionic lipids. Mutations, which extend the helical nature of this region, promoted an increased interaction. The possible role of the CP/lipid interaction in the SCPMV infection is discussed. (+info)Characterization of signal that directs C-tail-anchored proteins to mammalian mitochondrial outer membrane. (3/107)
We analyzed the signal that directs the outer membrane protein with the C-terminal transmembrane segment (TMS) to mammalian mitochondria by using yeast Tom5 as a model and green fluorescent protein as a reporter. Deletions or mutations were systematically introduced into the TMS or the flanking regions and their intracellular localization in COS-7 cells was examined using confocal microscopy and cell fractionation. 1) Three basic amino acid residues within the C-terminal five-residue segment (C-segment) contained the information required for mitochondrial-targeting. Reduction of the net positive charge in this segment decreased mitochondrial specificity, and the mutants were distributed throughout the intracellular membranes. 2) Elongation of the TMS interfered with the function of the C-segment and the mutants were delivered to the intracellular membranes. 3) Separation of the TMS and C-segment by linker insertion severely impaired mitochondrial targeting function, leading to mislocalization to the cytoplasm. 4) Mutations or small deletions in the region of the TMS flanking the C-segment also impaired the mitochondrial targeting. Therefore, the moderate length of the TMS, the positive charges in the C-segment, and the distance between or context of the TMS and C-segment are critical for the targeting signal. The structural characteristics of the signal thus defined were also confirmed with mammalian C-tail-anchored protein OMP25. (+info)Covalent cross-linking of proteins without chemical reagents. (4/107)
A facile method for the formation of zero-length covalent cross-links between protein molecules in the lyophilized state without the use of chemical reagents has been developed. The cross-linking process is performed by simply sealing lyophilized protein under vacuum in a glass vessel and heating at 85 degrees C for 24 h. Under these conditions, approximately one-third of the total protein present becomes cross-linked, and dimer is the major product. Chemical and mass spectroscopic evidence obtained shows that zero-length cross-links are formed as a result of the condensation of interacting ammonium and carboxylate groups to form amide bonds between adjacent molecules. For the protein examined in the most detail, RNase A, the cross-linked dimer has only one amide cross-link and retains the enzymatic activity of the monomer. The in vacuo cross-linking procedure appears to be general in its applicability because five different proteins tested gave substantial cross-linking, and co-lyophilization of lysozyme and RNase A also gave a heterogeneous covalently cross-linked dimer. (+info)Role of paired basic residues of protein C-termini in phospholipid binding. (5/107)
It is a well known phenomenon that the occurrence of several distinct amino acids at the C-terminus of proteins is non-random. We have analysed all Saccharomyces cerevisiae proteins predicted by computer databases and found lysine to be the most frequent residue both at the last (-1) and at the penultimate amino acid (-2) positions. To test the hypothesis that C-terminal basic residues efficiently bind to phospholipids we randomly expressed GST-fusion proteins from a yeast genomic library. Fifty-four different peptide fragments were found to bind phospholipids and 40% of them contained lysine/arginine residues at the (-1) or (-2) positions. One peptide showed high sequence similarity with the yeast protein Sip18p. Mutational analysis revealed that both C-terminal lysine residues of Sip18p are essential for phospholipid-binding in vitro. We assume that basic amino acid residues at the (-1) and (-2) positions in C-termini are suitable to attach the C-terminus of a given protein to membrane components such as phospholipids, thereby stabilizing the spatial structure of the protein or contributing to its subcellular localization. This mechanism could be an additional explanation for the C-terminal amino acid bias observed in proteins of several species. (+info)Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition. (6/107)
Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. To investigate the contribution of basic residues of the A helix of HCII to this activation, we constructed amino acid substitutions (K101Q, R103L, and R106L) by site-directed mutagenesis. K101Q greatly reduced heparin cofactor activity and required a more than 10-fold higher concentration of dermatan sulfate to accelerate thrombin inhibition compared with wild-type recombinant HCII. Thrombin inhibition by R106L was not significantly stimulated by dermatan sulfate. These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition. (+info)Site-directed mutagenesis of conserved charged amino acid residues in ClpB from Escherichia coli. (7/107)
ClpB is a member of a multichaperone system in Escherichia coli (with DnaK, DnaJ, and GrpE) that reactivates strongly aggregated proteins. The sequence of ClpB contains two ATP-binding domains, each containing Walker consensus motifs. The N- and C-terminal sequence regions of ClpB do not contain known functional motifs. In this study, we performed site-directed mutagenesis of selected charged residues within the Walker A motifs (Lys212 and Lys611) and the C-terminal region of ClpB (Asp797, Arg815, Arg819, and Glu826). We found that the mutations K212T, K611T, D797A, R815A, R819A, and E826A did not significantly affect the secondary structure of ClpB. The mutation of the N-terminal ATP-binding site (K212T), but not of the C-terminal ATP-binding site (K611T), and two mutations within the C-terminal domain (R815A and R819A) inhibited the self-association of ClpB in the absence of nucleotides. The defects in self-association of these mutants were also observed in the presence of ATP and ADP. The four mutants K212T, K611T, R815A, and R819A showed an inhibition of chaperone activity, which correlated with their low ATPase activity in the presence of casein. Our results indicate that positively charged amino acids that are located along the intersubunit interface (this includes Lys212 in the Walker A motif of the N-terminal ATP-binding domain as well as Arg815 and Arg819 in the C-terminal domain) participate in intersubunit salt bridges and stabilize the ClpB oligomer. Interestingly, we have identified a conserved residue within the C-terminal domain (Arg819) which does not participate directly in nucleotide binding but is essential for the chaperone activity of ClpB. (+info)Complete replacement of basic amino acid residues with cysteines in Rickettsia prowazekii ATP/ADP translocase. (8/107)
The ATP/ADP translocase (Tlc) of Rickettsia prowazekii is a basic protein with isoelectric point (pI)=9.84. It is conceivable, therefore, that basic residues in this protein are involved in electrostatic interactions with negatively charged substrates. We tested this hypothesis by individually mutating all basic residues in Tlc to Cys. Unexpectedly, mutations of only 20 out of 51 basic residues resulted in greater than 80% inhibition of transport activity. Moreover, 12 of 51Cys-substitution mutants exhibited higher than wild-type (WT) activity. At least in one case this up-effect was additive and the double mutant Lys422Cys Lys427Cys transported ATP five-fold better than WT protein. Since in these two single mutants and in the corresponding double mutant K(m)'s were similar to that of WT protein, we conclude that Tlc may have evolved a mechanism that limits the transporter's exchange rate and that at least these two basic residues play a key role in that mechanism. Based on the alignment of 16 Tlc homologs, the loss of activity in the mutants poorly correlates with charge conservation within the Tlc family. Also, despite the presence of three positively charged and one negatively charged intramembrane residues, we have failed to identify potential charge pairs (salt bridges) by either charge reversal or charge neutralization approaches. (+info)
Category:Basic amino acids
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Heparin Binding
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DNA and RNA codon tables
Amino-acid biochemical properties Nonpolar Polar Basic Acidic ↓ Termination: stop codon * Initiation: possible start codon ... Amino-acid biochemical properties Nonpolar Polar Basic Acidic ↓ Termination: stop codon * Initiation: possible start codon ... Amino-acid biochemical properties Nonpolar Polar Basic Acidic ↓ Termination: stop codon * Comparison between codon translations ... most specify an amino acid.[7] Three sequences, UAG, UGA, and UAA, known as stop codons,[note 1] do not code for an amino acid ...
Aquarium fish feed
Amino acids are the basic components of proteins. Protein requirements are species-specific. Carnivorous fish need a greater ... essential fatty acids and eight amino acids required for complete nutrition. Whole wheat (carbohydrates) is not the best source ... An example of an aquatic diet that is a good source of amino acid is a crumbled hard boiled egg offered to small fry. Large ... Squid Meal is a highly digestible protein source for fish which provides a full range of amino acids, vitamins, minerals and ...
Absolute configuration
A rule of thumb for determining the D/L isomeric form of an amino acid is the "CORN" rule. The groups: COOH, R, NH2 and H ( ... Moss, G. P. (1 January 1996). "Basic terminology of stereochemistry (IUPAC Recommendations 1996)". Pure and Applied Chemistry. ... For most amino acids, the L form corresponds to an S absolute stereochemistry, but is R instead for certain side-chains. ... For this reason, the D/L system remains in common use in certain areas of biochemistry, such as amino acid and carbohydrate ...
Brain
Amino acid neurotransmitters". In G. Siegel; et al. (eds.). Basic Neurochemistry. University of Michigan: Raven Press. pp. 311- ... caprylic and heptanoic acids), lactate, acetate, and possibly amino acids. Information from the sense organs is collected in ... Some basic types of responsiveness such as reflexes can be mediated by the spinal cord or peripheral ganglia, but sophisticated ... Although the same basic components are present in all vertebrate brains, some branches of vertebrate evolution have led to ...
Common descent
Amino acids nonpolar polar basic acidic Stop codon Standard genetic code 1st. base 2nd base ... amino acid sequences and DNA sequences. Proteins with the same three-dimensional structure need not have identical amino acid ... that code redundantly for the same amino acid. Since many species use the same codon at the same place to specify an amino acid ... Had the amino acid sequences come from different ancestors, they would have been coded for by any of the redundant codons, and ...
ARL6IP4
Two types of amino acid clusters have been observed, a serine cluster and a basic cluster. Its function(s) are unknown. However ... It is 360 amino acids in length. It is expressed ubiquitously but only in G1/S phase of the cell cycle. The human and mouse ... The amino acid change is conservative and is unlikely to massively alter protein function. However, the editing site may be ... Editing occurs at a K/R editing site within amino acid position 225 of the final protein. Using RT-PCR and sequencing of 100 ...
CKMT1A
... consists of 417 amino acids and weighs 47037Da. CKMT1A is rich in amino acids with hydroxyl-containing and basic side ...
Dansyl chloride
Walker JM (1994). "The Dansyl Method for Identifying N-Terminal Amino Acids". Basic Protein and Peptide Protocols. Methods Mol ... Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. Dansyl chloride ... fluorescence intensity of dansyl amino acids and dansyl proteins in aqueous media and its application to assay of amino acids ... This, in combination with their ability to accept energy (as in fluorescence resonance energy transfer) from the amino acid ...
Xylose isomerase
Both share an acid residue Glutamic acid 216 of the enzyme that bridges the two cations. Two basic amino acids surround the ... doi:10.1007/s10295-012-1089-x. Kitahara, K. (1966). "Studies on Lactic Acid Bacteria". Nyusankin no Kenkyu: 67~69. Buchanan, R. ...
腦 - 維基百科,自由的百科全書
Chapter 15, Amino acid neurotransmitters. (編) G. Siegel; 等. Basic Neurochemistry. Raven Press. 1989: 311-332. ISBN 978-0-88167- ... Basic Books. 1996. ISBN 978-0-465-07278-1.. *^ Sereno, MI; Dale, AM; Reppas, AM; Kwong, KK; Belliveau, JW; Brady, TJ; Rosen, BR ... Basic Neurochemistry Sixth. Lippincott Williams & Wilkins. 1999. ISBN 0-397-51820-X.. ... Mechanisms for selection of basic motor programs-roles for the striatum and pallidum. Trends in Neurosciences. 2005, 28 (7): ...
Coronin
The N-terminal region contains 12 basic amino acids which can be taken as signature as it is present in only coronin proteins. ... The number of amino acids in this region varies greatly. The unique region of Dictyostelium has 22 amino acids whereas ... Contain 450-650 amino acids with C-terminus coiled coil region of 30-40 amino acids that mediates homophilic dimerization and/ ... The WD-repeat is a structural motif comprising approximately 40 amino acids usually ending with the amino acid sequence ...
Dialysis (biochemistry)
Separation of amino acids into acidic, basic and neutral groups. Specifically, cytoplasmic leaf proteins are extracted from ... It induces an electrical power that will instigate a flux of the cations present in the less acid side to the more acid side. ... Acids can be recovered from aqueous solutions using anion-exchange membranes. That process is an alternative treatment of the ... It is used for the recovery of mixed acid (HF+ HNO3), the recovery and concentration of Zn2+ and Cu2+, in H2SO4+ CuSO4 and ...
Subtilase
These preferentially cleave C-terminally to paired basic amino acids. Members of this subfamily can be identified by subtly ... Over 200 subtilases are presently known, more than 170 of which with their complete amino acid sequence. Subtilase is ... with the mature catalytic domains containing approximately 375 amino acids. The defining features of these enzymes are a unique ... catalytic triad, Ser/Glu/Asp, as well as the presence of an aspartic acid residue in the oxyanion hole. High-resolution crystal ...
Melittin
... is a basic peptide consisting of 26 amino acids. The principal function of melittin as a component of bee venom is to ... the N-terminal part of the molecule is predominantly hydrophobic and the C-terminal part is hydrophilic and strongly basic. In ...
BZLF1
Each subunit has 245 amino acid residues. It has a basic leucine zipper domain, a characteristic of many transcription factors ...
DNA
Interaction of DNA (in orange) with histones (in blue). These proteins' basic amino acids bind to the acidic phosphate groups ... These encode the twenty standard amino acids, giving most amino acids more than one possible codon. There are also three 'stop ... Chemical modifications of these basic amino acid residues include methylation, phosphorylation, and acetylation.[109] These ... Deoxyribonucleic acid (/diːˈɒksɪˌraɪboʊnjuːˌkliːɪk, -ˌkleɪ-/ (. listen);[1] DNA) is a molecule composed of two chains that coil ...
Salt (chemistry)
Salt substitute Acid salt also known as "hydrogen salt" Alkali salts also known as "basic salts" Bresle method (the method used ... Examples of zwitterions include amino acids, many metabolites, peptides, and proteins. Solid salts tend to be transparent as ... carbonic acid) Chloride Cl− (hydrochloric acid) Citrate HOC(COO− )(CH 2COO− ) 2 (citric acid) Cyanide C≡N− (hydrocyanic acid) ... nitric acid) Nitrite NO− 2 (nitrous acid) Oxide O2− Phosphate PO3− 4 (phosphoric acid) Sulfate SO2− 4 (sulfuric acid) Salts ...
Motilin
... has 22 amino acids and molecular weight of 2698 Daltons. In extract from human gut and plasma, there are two basic ... The sequences of amino acids of motilin is: Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly ... Based on amino acid sequence, motilin is unrelated to other hormones. Because of its ability to stimulate gastric activity, it ... The second form, on the other hand, is larger and contains the same 22 amino acids as the first form but includes an additional ...
Soy sauce
Basic tastes can also be attributed to amino acid groups arranged in specific sequence. In soy sauce, it was found that "amino ... Based on the result of free amino acid analysis, the most abundant amino acids in Chinese soy sauce product are glutamic acid, ... This amino-glycosidic reaction gives soy sauce its dark brown color. Lactic acid bacteria ferments the sugars into lactic acid ... Over time, the Aspergillus mold on the soy and wheat break down the grain proteins into free amino acid and protein fragments ...
Tetratricopeptide repeat domain 16 isoform 1
In total, the TTC16 protein is 873 amino acids in length. There are two isoforms, of which variant 1 is the longest. There are ... "PB2 - Polymerase basic protein 2 - Influenza A virus (strain A/Wilson-Smith/1933 H1N1) - PB2 gene & protein". www.uniprot.org. ... There is only one known case of TTC16 interaction, involving polymerase basic protein 2 (pb2). Pb2 is involved in transcription ... The molecular weight is 98.3 kdal and the isoelectric point is 9.15 making TTC16 a basic protein. ...
Raventoxin
... -III is a basic polypeptide, consisting of 29 amino acid residues. It has a molecular mass of 3286.58 Da. Raventoxin- ... Raventoxin-I consists of 43 amino acid residues. It has a molecular mass of 4840.11 Da. The toxin is partially homologous to δ- ... Raventoxin-VI consists of 51 amino acid residues, and has a molecular weight of 5371.6 Da. All described raventoxins have shown ...
Soy sauce
Basic tastes can also be attributed to amino acids groups arranged in specific sequence. In soy sauce, it was found that "amino ... Based on the result of free amino acid analysis, the most abundant amino acids in Chinese soy sauce product are glutamic acid, ... This amino-glycosidic reaction gives soy sauce its dark brown color. Lactic acid bacteria ferments the sugars into lactic acid ... Acid-hydrolyzed vegetable protein[edit]. Some brands of soy sauce are made from acid-hydrolyzed soy protein instead of brewed ...
Orthomolecular psychiatry
... and new research on amino acids (3rd ed.). North Bergen, New Jersey: Basic Health. ISBN 978-1-59120-037-6.. ... amino acid metabolism, sphingolipid biosynthesis, and degradation).".[13] Specific conditions[edit]. Orthomolecularists claim ... amino acids, and other so-called "pharmacologic nutrients".[4] These diagnoses have not been accepted by mainstream medicine.[ ... carefully examined the literature produced by megavitamin proponents and by those who have attempted to replicate their basic ...
Zwitterion
Amino acids[edit]. An amino acid contains both acidic (carboxylic acid fragment) and basic (amine fragment) centres. The isomer ... The pKa values for deprotonation of the common amino acids span the approximate range 2.15±0.2. This is also consistent with ... The crystal and molecular structure of the amino acid α-glycine" (PDF). Acta Crystallographica Section B. 28 (6): 1827-1833. ... It is generally assumed that K , 1, that is, that the zwitterion is the predominant amino acid isomer in aqueous solution. It ...
Reflectin
Each sequence includes a combination of standard and sulphur-containing amino acids. Although the basic structure can be ... The recently identified protein family is enriched in aromatic and sulfur-containing amino acids, and is utilized by certain ... Reflectin is a disordered protein made up of conserved amino acid sequences. ...
Edward Trifonov
... for 20 basic amino acids). Trifonov averaged over them and got the proposed temporal order of the amino acids emergence, ... Consensus temporal order of amino acids Having the suspected first two triplets, they pondered which amino acids appeared the ... It is a network arrangement of sequence fragments of the length of 20 amino acids obtained from a collection of fully sequenced ... Later on, Trifonov collected even 101 criteria for the amino acids order. Each criterion could be represented as a vector of ...
Leucine zipper
... see basic amino acids in (provided table (sort by pH)) of certain amino acids in the "basic" domain, such as lysines and ... or leucine-like amino acids. These amino acids are spaced out in each region's polypeptide sequence in such a way that when the ... The bZIP domain is 60 to 80 amino acids in length with a highly conserved DNA binding basic region and a more diversified ... The NFIL3 protein has 462 amino acids including a b-ZIP domain . The N-terminal portion of the domain contains the basic motif ...
Perilipin-5
It contains four basic regions: from amino acid 1 to 173: key region for lipid droplet targeting. from amino acid 1 to 108: ... from amino acid 185 to 463: interactions with PNPLA2 and ABHD5. from amino acid 444 to 463: targets mitochondria for lipid ... It is composed of 463 amino acids, weighing an average of 50.8 kDa. ... On the other hand, this association may occur with the aim of protecting the mitochondria against toxic levels of fatty acids ...
Structure
The primary structure is the sequence of amino acids that make it up. It has a peptide backbone made up of a repeated sequence ... The two basic types are the α-helix and the β-pleated sheet. The tertiary structure is a back and forth bending of the ... Data structures are built out of two basic types: An array has an index that can be used for immediate access to any data item ... Atoms in a crystal have a structure that involves repetition of a basic unit called a unit cell. The atoms can be modeled as ...
Bile acid
Conjugating bile acids with amino acids lowers the pKa of the bile-acid/amino-acid conjugate to between 1 and 4. Thus ... Wiemuth D, Sahin H, Falkenburger BH, Lefevre CM, Wasmuth HE, Grunder S (2012). "BASIC--a bile acid-sensitive ion channel highly ... Cholic acid is converted into deoxycholic acid and chenodeoxycholic acid into lithocholic acid. All four of these bile acids ... Primary bile acidsEdit. Bile acid synthesis occurs in liver cells, which synthesize primary bile acids (cholic acid and ...
N-myristoyltransferase 1
1995). "Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic ... Liu J, Sessa WC (1994). "Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase ... Zhou W, Parent LJ, Wills JW, Resh MD (1994). "Identification of a membrane-binding domain within the amino-terminal region of ... 1985). "Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein". Science. 227 (4685): 427 ...
Centrifugation
By 1900, it had been generally accepted that proteins were composed of amino acids; however, whether proteins were colloids or ... "Centrifugation Basics". Sigma-Aldrich. Retrieved 10 May 2016.. *^ Article on "Centrifugation" retrieved on 15 October 2013 from ...
Chloroplast DNA
... rich in hydroxylated amino acids such as serine, threonine, and proline, and poor in acidic amino acids like aspartic acid and ... Special Issue: Biotechnology Annual Review 2010RNA Basics and Biotechnology Applications. 27 (3): 256-66. doi:10.1016/j.nbt. ... Chloroplast transit peptides exhibit huge variation in length and amino acid sequence.[42] They can be from 20-150 amino acids ... Tic100 is a nuclear encoded protein that's 871 amino acids long. The 871 amino acids collectively weigh slightly less than 100 ...
Rituximab
... binds to amino acids 170-173 and 182-185 on CD20, which are physically close to each other as a result of a disulfide ... a list of the most important medications needed in a basic health system.[46] ... bond between amino acids 167 and 183.[39] History[edit]. Rituximab was developed by researcher Nabil Hanna and coworkers at ...
Rituximab
... binds to amino acids 170-173 and 182-185 on CD20, which are physically close to each other as a result of a disulfide ... a list of the most important medications needed in a basic health system.[46] ...
Sake
Iron will bond with an amino acid produced by the kōji to produce off flavors and a yellowish color. Manganese, when exposed to ... There are two basic types of sake: Futsū-shu (普通酒, ordinary sake) and Tokutei meishō-shu (特定名称酒, special-designation sake). ... As the proportion of amino acids rises, the sake tastes more savory. This number is determined by titration of the sake with a ... aldehydes and amino acids, among other unknown factors.[23] Tōji[edit]. Tōji (杜氏) is the job title of the sake brewer, named ...
Lyme disease
... a derivative of amino acid beta-alanine), oil of lemon eucalyptus (OLE, a natural compound) and OLE's active ingredient para- ... "Patient education: What to do after a tick bite to prevent Lyme disease (Beyond the Basics)". www.uptodate.com. UpToDate. ... The spirochetes may also induce host cells to secrete quinolinic acid, which stimulates the NMDA receptor on nerve cells, which ... the IDSA recommends treatment with cefuroxime or amoxicillin/clavulanic acid, as these are effective against both infections.[ ...
Progesterone receptor
"Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochemical and Biophysical Research ... Zhang XL, Zhang D, Michel FJ, Blum JL, Simmen FA, Simmen RC (June 2003). "Selective interactions of Kruppel-like factor 9/basic ... which are identical except for an additional 165 amino acids present only in the N terminus of hPR-B.[12] Although hPR-B shares ... at the amino acid terminal. This segment is not present in the receptor-A. ...
Pleiotropy
Phenylalanine is an amino acid that can be obtained from food. Phenylketonuria causes this amino acid to increase in amount in ... One basic model of pleiotropy's origin describes a single gene locus to the expression of a certain trait. The locus affects ... which converts the amino acid phenylalanine to tyrosine. Depending on the mutation involved, this conversion is reduced or ... Other more complex models compensate for some of the basic model's oversights, such as multiple traits or assumptions about how ...
Dieting
In this process, fats, obtained from adipose tissue, or fat cells, are broken down into glycerol and fatty acids, which can be ...
腎上腺素 - 維基百科,自由的百科全書
Glutamate receptor antagonist(英語:Excitatory amino acid antagonist) (NMDA(英語:NMDA receptor antagonist)) ... Marks' basic medical biochemistry : a clinical approach 4. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ... Glutamate receptor agonist(英語:Excitatory amino acid agonist) (AMPA(英語:Ampakine)) ...
Coomassie Brilliant Blue
Through a study done at the University of Albany, it was shown that the ability of the Coomassie dye to target amino acids with ... aromatic groups (phenylalanine, tyrosine, tryptophan) and basic side chains (lysine, arginine and histidine), allows Bradford ... This provides a simpler method for fingerprint analysis by reducing the number of amino acids needed to be analyzed from 23 to ... A protein sample is added to a solution of the dye in phosphoric acid and ethanol. Under the acid conditions the dye is ...
Bioinformática, a enciclopedia libre
Needleman, S. y Wunsch, C. (1970). "A general method applicable to the search for similarities in the amino acid sequence of ... "Basic Local Alignment Search Tool" (PDF). Journal of Molecular Biology 215 (3). Arquivado dende o orixinal (PDF) o 13 de ... "Similar amino acid sequences: chance or common ancestry?". Science 214 (4517).. ... "Nucleic Acids Research 22 (17).. *↑ Un bo recurso de introdución a EMBnet é a páxina What is EMBnet? Arquivado 07 de setembro ...
Mineral (nutrient)
... essential fatty acids, and essential amino acids.[4] The five major minerals in the human body are calcium, phosphorus, ... amino acids, organic acids, etc.) improves the bioavailability of the supplemented mineral.[36] ... Ashmead, H. DeWayne (1993). The Roles of Amino Acid Chelates in Animal Nutrition. Westwood: Noyes Publications.. ... Needed for production of hydrochloric acid in the stomach and in cellular pump functions Table salt (sodium chloride) is the ...
Cyanotoxin
Amino acids[edit]. BMAA[edit]. The non-proteinogenic amino acid beta-Methylamino-L-alanine (BMAA) is ubiquitously produced by ... Alkaloids are a group of naturally occurring chemical compounds which mostly contain basic nitrogen atoms. They are produced by ... Amino Acid BMAA Nervous System All Most cyanotoxins have a number of variants (analogues). As of 1999, altogether over 84 ... A peptide is a short polymer of amino acids linked by peptide bonds. They have the same chemical structure as proteins, except ...
Tea
... such as the polyphenols and amino acids, but is a suspension when all of the insoluble components are considered, such as the ... After basic processing, teas may be altered through additional processing steps before being sold,[84] and is often consumed ... Williamson, G; Dionisi, F; Renouf, M (2011). "Flavanols from green tea and phenolic acids from coffee: critical quantitative ... with additions to the basic tea leaf and water added during preparation or drinking. Examples of additional processing steps ...
Archaea
... it lacks D-amino acids and N-acetylmuramic acid.[102]. Archaea flagella operate like bacterial flagella-their long stalks are ... The energy released is used to generate adenosine triphosphate (ATP) through chemiosmosis, the same basic process that happens ... Deppenmeier, U. (2002). "The unique biochemistry of methanogenesis". Prog Nucleic Acid Res Mol Biol. Progress in Nucleic Acid ... acetic acid or formic acid are used as alternative electron acceptors by methanogens. These reactions are common in gut- ...
Histone
Salt bridges and hydrogen bonds between side chains of basic amino acids (especially lysine and arginine) and phosphate oxygens ... The single-letter amino acid abbreviation (e.g., K for Lysine) and the amino acid position in the protein ... compared amino acid compositions in the same histone from different organisms, and compared amino acid sequences of the same ... 3. Complete amino acid sequence of pea seedling histone IV; comparison with the homologous calf thymus histone". The Journal of ...
Biofuel
Escherichia coli strains have also been successfully engineered to produce butanol by modifying their amino acid metabolism.[36 ... Biomass and the Environment - Basics *^ a b "Biofuels Make a Comeback Despite Tough Economy". Worldwatch Institute. 2011-08-31 ... The fuel is created from general urban waste which is treated by bacteria to produce fatty acids, which can be used to make ... Chemically, it consists mostly of fatty acid methyl (or ethyl) esters (FAMEs). Feedstocks for biodiesel include animal fats, ...
Glycogen phosphorylase
The glycogen phosphorylase monomer is a large protein, composed of 842 amino acids with a mass of 97.434 kDa in muscle cells. ... Pyridoxal phosphate links with basic residues (in this case Lys680) and covalently forms a Schiff base. Once the Schiff base ...
Peroxisome
They are involved in catabolism of very long chain fatty acids, branched chain fatty acids, D-amino acids, and polyamines, ... Peroxisomes contain oxidative enzymes, such as D-amino acid oxidase and uric acid oxidase.[9] However the last enzyme is absent ... Specific amino acid sequences (PTS or peroxisomal targeting signal) at the C-terminus (PTS1) or N-terminus (PTS2) of ... The protein receptors, the peroxins PEX5 and PEX7, accompany their cargoes (containing a PTS1 or a PTS2 amino acid sequence, ...
Amine
Protonated amino groups (-NH+. 3) are the most common positively charged moieties in proteins, specifically in the amino acid ... Because amines are basic, they neutralize acids to form the corresponding ammonium salts R3NH+. When formed from carboxylic ... carboxylic acid. −. ,. H. −. N. +. ,. R. 2. R. 1. ,. −. H. +. R. 3. −. COO. −. ⏟. substituted-ammonium. carboxylate salt. →. d ... The breakdown of amino acids releases amines, famously in the case of decaying fish which smell of trimethylamine. Many ...
Yohimbine
... the cognitive aspects of sex are far more important in humans than the basic instinctive functions observed in animals.[9] ... 17α-hydroxyyohimban-16α-carboxylic acid methyl ester. CAS Number. *146-48-5 Y ... 2-Amino-1,2-dihydronaphthalene. *2-Aminoindane. *5-(2-Aminopropyl)indole. *2-Aminotetralin ...
Brain-derived neurotrophic factor
... results in an amino acid switch: valine to methionine exchange at codon 66, Val66Met, which is in the prodomain of BDNF.[39][38 ... because normally CREB interaction with CRE and the subsequent translation of the BDNF transcript is blocked by of the basic ... as the amino acid change occurs on the portion of the prodomain where sortilin binds; and sortilin is essential for normal ... neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ...
ವಂಶವಾಹಿ - ವಿಕಿಪೀಡಿಯ
Implications of Comparative Analysis of Amino Acid Sequences". Critical Reviews in Biochemistry and Molecular Biology 28 (5): ... "Understanding the Basics". The Human Genome Project. Retrieved 26 April 2015. *↑ "WS227 Release Letter". WormBase. 10 August ... Watson, J. D.; Crick, FH (1953). "Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" (PDF). Nature ... Domingo, E; Escarmís, C; Sevilla, N; Moya, A; Elena, SF; Quer, J; Novella, IS; Holland, JJ (June 1996). "Basic concepts in RNA ...
RNA world
Amino acid-RNA ligation. The ability to conjugate an amino acid to the 3'-end of an RNA in order to use its chemical groups or ... Bell, Graham: The Basics of Selection. Springer, 1997. *^ Orgel LE (Oct 1994). "The origin of life on the earth". Scientific ... As some co-factors contain both nucleotide and amino-acid characteristics, it may be that amino acids, peptides and finally ... as no amino acid molecules lie within 18Å of the enzyme's active site,[15] and, when the majority of the amino acids in the ...
Innate immune system
"Amino Acids. 38 (5): 1283-99. doi:10.1007/s00726-009-0374-0. PMC 2860555. PMID 19882216.. ... Klingemann HG (2010). "Development and testing of NK cell lines". In Lotze MT, Thompson AW (eds.). Natural killer cells - Basic ... Sweat, desquamation, flushing,[2] organic acids[2] Gastrointestinal tract. Peristalsis, gastric acid, bile acids, digestive ... such as salicylic acid or jasmonic acid. Some of these travel through the plant and signal other cells to produce defensive ...
Food chemistry
Food and Nutrition Board of Institute of Medicine (2005) Dietary Reference Intakes for Protein and Amino Acids, page 685, from ... IFT Basic Symposium Series, Marcel Dekker, Inc.:New York, 793 pages *^ Physical Chemistry of Food Processes, Advanced ... fatty acids (including essential fatty acids), fatty-acid derived phospholipids, sphingolipids, glycolipids and terpenoids, ... Such artificial flavours include methyl salicylate which creates the wintergreen odor and lactic acid which gives milk a tart ...
Vitamin C
Mineral Nutrients and Amino Acids May or Must be Added.[87] Voluntary and mandatory fortification was described for various ... The world price of vitamin C rose sharply in 2008 partly as a result of rises in basic food prices but also in anticipation of ... Ascorbic acid is a weak sugar acid structurally related to glucose. In biological systems, ascorbic acid can be found only at ... The biosynthesis of ascorbic acid in vertebrates starts with the formation of UDP-glucuronic acid. UDP-glucuronic acid is ...
Basics for: Carbohydrates, Proteins, Amino Acids and Lipids | Physics Forums
Amino Acids and Lipids) for about a week and I just dont... ... I have been trying to get my head around the basics for these ... Made only of amino acids. Make up structure of your body. Can be used for energy.. Amino Acids - made of the same elements as ... Related Threads on Basics for: Carbohydrates, Proteins, Amino Acids and Lipids Can your body synthesise protein from ... I have been trying to get my head around the basics for these four (Carbohydrates, Proteins, Amino Acids and Lipids) for about ...
Basic amino acids - Biology-Online Dictionary
Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis | PNAS
The amino acid sequence of human gamma-trace, a basic microprotein without known function, was determined by automated Edman ... Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. A Grubb and H Löfberg ... Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis ... Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis ...
Amino Acid Transporter Laboratory - Institute of Basic Medical Sciences
Amino Acid Transporter Laboratory. This research group is focused on transport and cycling of neurotransmitters and amino acids ... Amino acids, and in particular glutamine, are involved in a variety of metabolic pathways. Glutamine is the most abundant amino ... It is a major carbon and nitrogen donor, and it contributes to the formation of other amino acids, nucleotides and the anti- ... We investigate molecular mechanisms involved in glutamine (and other amino acids) transport across cell membranes subsequent ...
All Basic Amino Acids | Montiff
... plus precursor Ornithine-Ketoglutarate and Alpha Lipoic Acid for. ... unique blend of 20 highest quality L-Crystalline singular amino ... All-Basic Powder 350 gms , Montiff. All-Basic-Plus 750 mg 500 caps. Dietary Supplement. • Advanced L-Crystalline Amino Acid ... All-Basic Powder 350 gms , Montiff. A unique blend of 20 highest quality L-Crystalline singular amino acids, plus precursor ... Desiccant pads are included in All-Basic Amino Acid Formula, as well as all of Montiffs highest quality nutraceuticals, to ...
Both Basic and Acidic Amino Acid Residues of Are Involved in Triggering Substate of RyR1
A cluster of basic amino acid residues in calcineurin b participates in the binding of calcineurin to phosphatidylserine...
A cluster of basic amino acid residues in calcineurin b participates in the binding of calcineurin to phosphatidylserine ... In the present study we tested the effects of mutations of calcineurin B subunit amino acid residues K(20)K(21), K(24)R(25), K( ... These results indicate that calcineurin B contains an amino terminal basic residue cluster that is involved in the binding of ... Interactions between phospholipid membranes and the acyl chain and specific amino acid residues of myristoylated proteins are ...
Neurospora mutants affecting polyamine-dependent processes and basic amino acid transport mutants resistant to the polyamine...
All but one of thirty mutants were allelic, and were specifically deficient in the basic amino acid permease. This mechanism of ... Neurospora mutants affecting polyamine-dependent processes and basic amino acid transport mutants resistant to the polyamine ... Neurospora mutants affecting polyamine-dependent processes and basic amino acid transport mutants resistant to the polyamine ... Neurospora mutants affecting polyamine-dependent processes and basic amino acid transport mutants resistant to the polyamine ...
Neutral and basic amino acid transport protein rBAT - Wikipedia
"Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid ... "Sodium-independent Currents of Opposite Polarity Evoked by Neutral and Cationic Amino Acids in Neutral and Basic Amino Acid ... Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene. Mutations in the ... amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter". J. Biol. Chem. 275 (19): 14331- ...
Genosphere : Amino Acid Basic Properties
Frontiers | BASIC AMINO ACID CARRIER 2 gene expression modulates arginine and urea content and stress recovery in Arabidopsis...
The Arabidopsis nuclear gene BASIC AMINO ACID CARRIER 2 (BAC2) encodes a mitochondria-located carrier that transports basic ... The Arabidopsis nuclear gene BASIC AMINO ACID CARRIER 2 (BAC2) encodes a mitochondria-located carrier that transports basic ... When BAC2 is overexpressed in vivo, it triggers catabolism of arginine, a basic amino acid, leading to arginine depletion and ... When BAC2 is overexpressed in vivo, it triggers catabolism of arginine, a basic amino acid, leading to arginine depletion and ...
Basic Concepts, Amino Acids, Proteins Flashcards by Paige Johnson | Brainscape
Study Basic Concepts, Amino Acids, Proteins flashcards from Paige Johnson ... Basic Concepts, Amino Acids, Proteins Flashcards Preview Biochem , Basic Concepts, Amino Acids, Proteins , Flashcards ... The pH at which the net charge on an amino acid is 0 ... linear polymers of α-amino acids bound together by peptide ... Helical structure stabilized by hydrogen bonds (b/t amino and carboxyl O atom of 2nd AA 4 residues down the chain) ...
The effect of chemical modification of basic amino acid residues on the activation and amidolytic activity of Hageman factor ...
Thus, basic amino acid residues essential to the activation or activity of Hageman factor appear to be variably accessible to ... The effect of chemical modification of basic amino acid residues on the activation and amidolytic activity of Hageman factor ( ... Activation is also inhibited by alteration of the other two basic amino acid residues present, lysine and histidine. Chemical ... Amino Acids / chemistry*. Arginine / chemistry. Diethyl Pyrocarbonate / pharmacology. Factor XII / antagonists & inhibitors, ...
Is glutamine a basic amino acid? - Answered by top doctors on HealthTap
Glutamine is an Amino Acid (basic building block of proteins). People take it for various reasons as a dietary supplement. It ... In brief: Glutamine amino acid Glutamine is an Amino Acid (basic building block of proteins). ... In brief: Glutamine amino acid Glutamine is an Amino Acid (basic building block of proteins). ... if I am also taking the amino acid supplements L-tyrosine and L-glutamine? I took the amino acids roughly 5 hours ago. ...
Human Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) Protein (His tag,GST tag), Recombinant | ABIN1879431
Paired Basic Amino Acid Cleaving Enzyme) (FURIN) Protein (His tag,GST tag). Species: Human. Source: Escherichia coli (E. coli ... Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 587-748) protein (His tag,GST tag) Protein FURIN Origin: Human ... Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 578-734) protein (His tag,GST tag) Protein ... Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 108-793) protein (rho-1D4 tag) Protein ...
Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme) FURIN-605H - Creative BioMart
FURIN furin (paired basic amino acid cleaving enzyme) [ Homo sapiens ]. Synonyms:. FURIN; furin (paired basic amino acid ... paired basic amino acid residue-cleaving enzyme; EC 3.4.21.75; paired basic amino acid cleaving enzyme (furin, membrane ... Recombinant Human Furin (Paired Basic Amino Acid Cleaving Enzyme). Download Datasheet See All FURIN Products. Bring this ... Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).. ...
JAIRO | Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides Using Basic-to-Acidic Flash Switching in a Micro-flow...
Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides Using Basic-to-Acidic Flash Switching in a Micro-flow ReactorRapid ... Rapid and Mild Synthesis of Amino Acid N-Carboxy Anhydrides Using Basic-to-Acidic Flash Switching in a Micro-flow Reactor. ... and Mild Synthesis of Amino Acid N-Carboxy Anhydrides Using Basic-to-Acidic Flash Switching in a Micro-flow Reactor. ...
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Proton affinity of several basic non-standard amino acids FULIR
Rožman, Marko (2012) Proton affinity of several basic non-standard amino acids. Chemical Physics Letters, 543 . pp. 50-54. ISSN ... 2-amino-3-guanidinopropionic acid, 2-amino-4-guanidinobutyric acid, homoarginine, citrulline and canavanine), histidine (1- ... For a majority of here studied non-standard amino acids the gas- phase proton affinities were established for the first time, ... methylhistidine and 3- methylhistidine) and lysine (2, 3-diaminopropanoic acid, 2, 4-diaminobutanoic acid, ornithine, 5- ...
Amino Acid & Protein Basics - Colloids For Life Blog
An amino acid may be a singlet (single amino acid) or connected to many other amino acids. Amino Acids form short polymer ... Amino Acid Basics. In biochemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. Amino ... Amino Acid & Protein Basics - A Welltrient Health Tip. We use amino acids in almost every product for the body proper. And we ... Body Basics. In the body, all ingested proteins are broken down to their various amino acids components. Internally, the amino ...
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How Many Different Kinds of Amino Acids Make Up a Protein? | LIVESTRONG.COM
Amino acids are substances you rely on to form all the proteins in your body. In turn, you rely on these proteins for vital ... Any given protein contains roughly 20 different amino acids.. Amino Acid Basics. While there are more types of amino acids in ... While all proteins contain roughly the same complement of amino acids, the order of those acids dictates both the basic shape ... These bonds form between the carboxyl group of one amino acid and the amino group of its neighboring acid. The same type of ...
Cas 173106-27-9,29,30-Dinorlupan-20-oic acid, 28-[(10-carboxydecyl)amino]-3-hydroxy-28 -oxo-, (3beta.)- | lookchem
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Back to the Basics: An Overview Of Amino Acids - Dr. Amino
Here is an overview of basic information about amino acids and how and why they are perfectly suited for, and in fact ... Home , Amino Acids , Back to the Basics: An Overview Of Amino Acids ... an amino acid contains an amino group (with a nitrogen atom) and a carboxylic acid functional group. In addition, each amino ... Amino Acids in Balance. Every amino acid can serve as a structural component of protein, skeletal muscle being the main ...
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The comparison between 9 home-made amino acid- and peptide-silica stationary... ... Amino acids and peptides (di- and tripeptides) as chemically bonded ligands in liquid chromatography were investigated. ... In the case of basic columns, such as amino-(Phe)x, amino-(Leu)x, amino-(Gly)1, and amino-(Ala)2 the α(Tb/Tp) value was smaller ... amino-(Gly)1, amino-(Gly)3, amino-(Asp)1, amino-(Ala)2, amino-(Leu)1, amino-(Leu)2, amino-(Leu)3, amino-(Phe)1, and amino-(Phe) ...
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Amino acids are essential for the overall development of the body since they are building blocks of protein joined together by ... Acidic and Basic Amino Acids. Aspartic and glutamic acid are referred to as acidic amino acids while arginine, histidine, and ... Facts About Amino Acids. Are amino acids proteins?. Amino acids and proteins are constantly confusing. Amino acids are building ... Branched-Chain Amino Acids (BCAAs). Branched-Chain Amino Acids (BCAAs). These are essential amino acids that trigger the ...
Structural Biochemistry/Proteins/Amino Acids - Wikibooks, open books for an open world
Acidic : aspartic acid, glutamic acid. Basic : histidine, lysine, arginine. List of the 20 Amino Acids[edit]. Amino Acid 3- ... 2-amino acids, also known as alpha-amino acids, are a specific type of amino acid that makes up proteins. These amino acids ... Amino Acids[edit]. Amino acids are molecules which contain both a carboxylic acid and an amine group. In amino acid, the ... Ionization of amino acids[edit]. The 20 standard amino acids have two acid-base gorups: the alpha-amino and the alpha-carboxyl ...
Artificial saliva containing amino acid and using basic amino acid for treating dry mouth
Basic amino acids that can be used in the compositions and methods of the invention include not only natural basic amino acids ... Any of the preceding compositions, in which the salt of the basic amino acids get by neutralization of the basic amino acids ... salt of the basic amino acids get in the finished form in situ by neutralization of the basic amino acid or salt of the acid. ... in which the basic amino acid is an arginine.. 1.0.5. Any of the preceding compositions, in which the basic amino acid is an L- ...
ProteinsArginineLEUCINEProteinHistidinePeptidesResiduesGlycineAlaninePaired Basic Amino Acid Cleaving EnzymeMethionineTypes of amino acidsGlucogenic aminoCarboxylicIndividual aminoNeutralCysteineOrnithineGLUTAMIC ACIDNitrogenPolypeptidesHydrogenSpecific amino acidChemicalHydrophobicTyrosineGlutamineSynthesisUnnatural amino acidsBiochemistryASPARTIC ACIDCharacterization of Amino AcidChemicallyEssentialProteinogenic aminoTransports basic amino acidsTransportersEnzymesSequence of amino acidsMetabolism of amino acidsFatty acidsSupplementsNucleic acidAcidic aminoBcaaMajor amino acidsNonessential amino acidsPROLINEPermease
Proteins58
- I have been trying to get my head around the basics for these four (Carbohydrates, Proteins, Amino Acids and Lipids) for about a week and I just don't understand the basic structure, formulas and such. (physicsforums.com)
- You say amino acids and proteins. (physicsforums.com)
- Before the proteins are synthesised from aminoacids the aminoacids have to be biosynthesised too. (physicsforums.com)
- We also investigate how glutamine transport and metabolism are regulated by extracellular and intracellular growth factors, amino acid levels and interacting proteins and their impact on cell structure and function. (uio.no)
- Interactions between phospholipid membranes and the acyl chain and specific amino acid residues of myristoylated proteins are necessary for membrane association. (nih.gov)
- A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. (pnas.org)
- The results suggest that this conserved arginine residue in the basic regions of Myc-related bHLH proteins discriminates between CAC(A/G)TG and related sites. (pnas.org)
- In plants, basic amino acids are important for the synthesis of proteins and signaling molecules and for nitrogen recycling. (frontiersin.org)
- Glutamine is an Amino Acid (basic building block of proteins). (healthtap.com)
- Shaped like the letter "C," these compounds wrap around chains of lysine, a basic amino acid that is a constituent of most proteins. (thefreedictionary.com)
- With tens of thousands of proteins in our body-and all of them constructed from amino acids-the protein-related role of amino acids is definitely critical in support of our health (and especially the health of our immune system). (whfoods.org)
- There are tens of thousands of unique proteins in our body, and every one of these proteins is constructed from amino acids. (whfoods.org)
- This relationship between amino acids and proteins has been the driving force behind nutritional research on these fascinating nutrients. (whfoods.org)
- Amino acids that are used to make proteins are referred to as "proteinogenic" amino acids. (whfoods.org)
- In addition to these 20 core amino acids, there are three additional amino acids that can be used by our bodies to make proteins. (whfoods.org)
- Researchers estimate that an additional 750-1,000 amino acids are present in living things and are routinely used for a wide variety of purposes not related to the building of proteins. (whfoods.org)
- Proteins are long linear polymers (polypeptides) built from strings of 20 different alpha-amino acids. (colloidsforlife.com)
- Proteins are large organic compounds arranged in a linear chain and joined together by peptide bonds between the carboxyl and amino groups of adjacent amino acid residues. (colloidsforlife.com)
- Proteins are chemically constructed from only amino acids (carbon, hydrogen, nitrogen (about 16%), oxygen and sometimes sulfur). (colloidsforlife.com)
- Amino acids are the â€Å"building blocks†that make up the proteins and is what distinguishes Proteins from carbohydrates and fats. (colloidsforlife.com)
- In the body, all ingested proteins are broken down to their various amino acids components. (colloidsforlife.com)
- The body stores the other caloric nutrients, but not proteins or amino acids (use or lose it baby), which is why it is vital for people to consume all the required essential amino acids daily. (colloidsforlife.com)
- All of the body†s proteins are made up from various combinations of these 20 proteinogenic amino acids. (colloidsforlife.com)
- Amino acids are substances you rely on to form all the proteins in your body. (livestrong.com)
- While there are more types of amino acids in your body, you need just 20 to form all of your various proteins. (livestrong.com)
- While all proteins contain roughly the same complement of amino acids, the order of those acids dictates both the basic shape of each protein and its function in your body. (livestrong.com)
- Proteins, in turn, contain relatively long amino acid chains, and scientists sometimes call them polypeptides. (livestrong.com)
- When you eat any food in your diet that contains protein, your body absorbs that protein, breaks it down into individual amino acids, then uses these acids to form the specific proteins you need to support your normal body function. (livestrong.com)
- Proteins in themselves are made up of smaller items called Amino Acids, there are 20 true individual Amino Acids which our body uses. (freewebs.com)
- Different types of Proteins contain different proportions and concentrations of these Amino Acids, in fact some proteins doesn't contain some of these Amino Acids at all. (freewebs.com)
- Beyond serving as the building blocks for all-important proteins, amino acids are in and of themselves important signaling factors and intermediaries in many metabolic pathways. (52.52.137)
- While hundreds of amino acids exist, we will concern ourselves only with those that are referred to as "proteinogenic," which means they are used in the making of all biological proteins. (52.52.137)
- Currently, there is a great deal of interest in identifying functional benefits of individual amino acids beyond their role as constituents of proteins. (52.52.137)
- These are essential amino acids that trigger the production of proteins in the muscles. (dietspotlight.com)
- Proteins are polymers of multiple monomer units called amino acid, which have many different functional groups. (wikibooks.org)
- More than 500 amino acids exist in nature, but the proteins in all species, from bacteria to humans, consist mainly of only 20 called the essential amino acids. (wikibooks.org)
- 2-amino acids, also known as alpha-amino acids, are a specific type of amino acid that makes up proteins. (wikibooks.org)
- Amino acids play central roles both as building blocks of proteins and as intermediates in metabolism. (wikibooks.org)
- Proteins are linear polymers formed by linking the a-carboxyl group of one amino acid to the a-amino group of another amino acid. (wikibooks.org)
- Thus, the 20 amino acids that are found within proteins convey a vast array of chemical versatility. (wikibooks.org)
- The chemical properties of the amino acids of proteins determine the biological activity of the protein. (wikibooks.org)
- In addition, proteins contain within their amino acid sequences the necessary information to determine how that protein will fold into a three dimensional structure, and the stability of the resulting structure. (wikibooks.org)
- There are twenty major amino acids which make up proteins. (wikibooks.org)
- Human cells are a combination of water, proteins, carbohydrates, nucleic acids and fats contained in a lipid-based membrane. (reference.com)
- An amino acid pool is the collection of amino acids available in an organism's cells at a given time, based on the proteins and fats recently consumed by t. (reference.com)
- Amino acids are the building blocks for proteins in the body. (medlineplus.gov)
- Amino acids, peptides, and proteins. (medlineplus.gov)
- Amino acids are the basic structural building blocks of proteins . (newworldencyclopedia.org)
- Just as the letters of the alphabet can be combined in different ways to form an endless variety of words, a limited number of amino acids can be linked together in varying sequences to form a vast array of proteins. (newworldencyclopedia.org)
- We found that efficient localization of P. sojae nuclear proteins by cNLSs requires additional basic amino acids at distal sites or collaboration with other NLSs. (frontiersin.org)
- The text begins with the discoveries and basic concepts of amino acids, peptides, and proteins, and then moves to protein digestion and absorption of peptides and amino acids. (routledge.com)
- The basic subunit of proteins. (wikibooks.org)
- This produced amino acids, the building blocks of all proteins. (newscientist.com)
- Arginine is one of the amino acids produced in the human body by the digestion, or hydrolysis of proteins. (encyclopedia.com)
- To understand the role that these basic amino acid residues play in toxicity, STII was chemically modified with ethoxyformic anhydride, maleic anhydride, and phenylglyoxal, which alter the side chains of basic amino acid residues in proteins. (elsevier.com)
- For one thing, when you drink a protein shake, your body must break the peptide bonds between the amino acids contained in those proteins via digestion before they can be absorbed into the bloodstream and sent along to the muscles. (amino-vital.com)
- BCAA supplements, on the other hand, are made from free-form amino acids, meaning that they're not joined together by bonds like the amino acids found in whole proteins. (amino-vital.com)
- Hemp is one of the most complete proteins in the plant nourishment realm, containing ALL 21 known amino acids, including the 9 that people can't deliver themselves. (selfgrowth.com)
Arginine14
- ALL-BASIC formula has proper Lysine to Arginine balance. (forresthealth.com)
- When BAC2 is overexpressed in vivo , it triggers catabolism of arginine, a basic amino acid, leading to arginine depletion and urea accumulation in leaves. (frontiersin.org)
- The BAC2 carrier is therefore involved in controlling the balance of arginine and arginine-derived metabolites and its associated amino acid metabolism is physiologically important in equipping plants to respond to and recover from stress. (frontiersin.org)
- However, the transport of arginine to the mitochondria in plants is important because arginine is a protein building block, a metabolic precursor of other amino acids, and a form in which nitrogen is assimilated. (frontiersin.org)
- The basic amino acids are arginine, histidine, and lysine. (thefreedictionary.com)
- These six (Cysteine, Glutamic acid, Glycine, Histidine, Arginine, Tyrosine) are conditionally â€Å"Essential Amino Acids†, each one is not normally required in the diet, but must be supplied exogenously because, they are not synthesize in adequate amounts by some groups of people. (colloidsforlife.com)
- Aspartic and glutamic acid are referred to as acidic amino acids while arginine, histidine, and lysine are basic. (dietspotlight.com)
- Application of basic amino acids such as arginine, in the finished form of toothpastes known in this field, however, the inventors have revealed unexpected and surprising result when using toothpastes containing arginine bicarbonate, people suffering from xerostomia, namely, that such compositions alleviate, treat and slow the development of dry mouth. (russianpatents.com)
- I believe that the basic amino acids, for example arginine, can be used to prevent cavities without or in the absence of fluoride, as salts of basic amino acids, for example, arginine bicarbonate, in combination with an insoluble salt of calcium, usually abrasive material for toothpaste, mimic the protective effects of saliva against caries and provide full protection of tooth enamel and roots by covering the tooth. (russianpatents.com)
- The three consecutive DNA bases, called nucleotide triplets or codons, are translated into amino acids (GCA to alanine , AGA to arginine , GAT to aspartic acid , AAT to asparagine , and TGT to cysteine in this example). (wikipedia.org)
- Arginine and histidine may also be classified as essential amino acids, though they are generally considered essential only in children, whose undeveloped metabolisms are unable to synthesize them. (newworldencyclopedia.org)
- Supplements that combine arginine with other amino acids, such as ornithine and lysine , are purported to assist in muscle-building exercises by minimizing body fat and maximizing muscle tone. (encyclopedia.com)
- Arginine is also present in "multi" amino acids capsules that are taken as a dietary supplement. (encyclopedia.com)
- Recent studies using stable isotope labeling with amino acids in culture (SILAC) in quantitative proteomics have made mention of the problematic conversion of isotope-coded arginine to proline in cells. (mcponline.org)
LEUCINE8
- Eighteen of the 20 â€Å"Proteinogenic Amino Acids†are â€Å"Glucogenic Amino Acids†and have caloric ability, only leucine and lysine do not. (colloidsforlife.com)
- The investigated stationary phases were modified by the following amino acids: phenylalanine, leucine, alanine, glycine, and aspartic acid. (springer.com)
- This conversion happens to all glucogenic amino acids except lysine and leucine. (dietspotlight.com)
- Leucine is an amino acid required to build muscle, but it also acts as a signaling molecule informing the muscle to start protein synthesis. (clinicaltrials.gov)
- BCAA are comprised of 3 different amino acids (leucine, isoleucine and valine). (clinicaltrials.gov)
- A significant excess of amino acid polymorphism segregating within this species is localized within the leucine-rich repeat (LRR) domain of RPP13 . (genetics.org)
- Leucine - As the branched-chain amino acid that's been most widely studied, there is significant evidence 1 supporting the many benefits of this BCAA. (amino-vital.com)
- Leucine is the amino acid responsible for triggering the synthesis of new skeletal muscle, making it essential for anyone looking to increase strength or muscle mass. (amino-vital.com)
Protein57
- The tissue localization and amino acid sequence of gamma-trace indicated that this protein is connected with the peptidergic gastroenteropancreatic neuroendocrine system. (pnas.org)
- Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene. (wikipedia.org)
- Amino acids are best-known as the building blocks for protein, and that reputation is well-deserved. (whfoods.org)
- While some people may take this group for granted and assume that it involves interesting but unnecessary details related to protein, and while others may imagine it as a very specialized area related to body building and physical performance, amino acids are actually spotlight nutrients that all of us would do well to consider when making routine food choices. (whfoods.org)
- Amino acids are most commonly described as the building blocks of protein . (whfoods.org)
- It does not matter whether a protein is very small and contains several dozen amino acids, or very large and contains more than 10,000 amino acids, or just average-sized and composed of 200-300 amino acids. (whfoods.org)
- Twenty core amino acids are all that it takes to make every single protein in our body. (whfoods.org)
- The list below shows all 20 of these core protein-building amino acids in alphabetical order. (whfoods.org)
- The method that scientists have used to determine the protein-building role of these 20 core amino acids involves our genetic code. (whfoods.org)
- Within our genes can be found direct instructions for making all 20 of these core protein-building amino acids. (whfoods.org)
- The three additional protein-building amino acids are selenocysteine, pyrrolysine, and N-formylmethionine. (whfoods.org)
- What's perhaps most surprising about these 23 protein-building amino acids is the fact that they only account for about 2% of all amino acids. (whfoods.org)
- Some non-protein building amino acids have been well-researched from the standpoint of metabolism, but less well investigated from the standpoint of food. (whfoods.org)
- We expect non-protein building amino acids to become the subject of increased research attention in future studies on foods and meal planning. (whfoods.org)
- When making nutritional recommendations for our everyday diet, health scientists have expressed much more confidence in estimating our total protein needs than in estimating our need for individual amino acids. (whfoods.org)
- Amino acids are the buildings blocks of protein in your body. (aminoco.com)
- In short, when it comes to protein synthesis and literally building new muscle, you cannot do it without your amino acids. (aminoco.com)
- build protein, build one of the 40,000 â€Å"amino acid complexes†, converted to glucose and used as a fuel, secreted as waste, and more. (colloidsforlife.com)
- The body makes protein from 20 different â€Å"free amino acids†not from dietary protein, through a process called translation. (colloidsforlife.com)
- Besides functioning in our body as a protein building block, Amino acids have are biological molecules, forming parts of enzymes, coenzymes, biosynthesis precursors for molecules and more. (colloidsforlife.com)
- All usable amino acids in our food originate as protein. (colloidsforlife.com)
- How Many Different Kinds of Amino Acids Make Up a Protein? (livestrong.com)
- Any given protein contains roughly 20 different amino acids. (livestrong.com)
- The specific amino acid content of any given protein is determined by the genetic instructions inside the cell that creates it. (livestrong.com)
- The genetic instructions from the parent cell also determine the order of the amino acids inside a protein. (livestrong.com)
- The connections that hold the amino acids together inside any given protein are called peptide bonds. (livestrong.com)
- The same type of amino acid can appear inside a protein multiple times. (livestrong.com)
- When an amino acid chain contains a relatively short sequence of acids, it is commonly called a peptide rather than a protein. (livestrong.com)
- The basic building blocks for protein are a. glucose units. (bartleby.com)
- But we also lose protein on a daily basis as muscles and tissues degrade and amino acids are oxidized. (52.52.137)
- Amino acids (20 in total for biological purposes) are important organic compounds that exist in all protein-containing food sources. (52.52.137)
- On the other hand, efforts to lose weight for health can be helped along by the added calorie cost of processing protein and making nonessential amino acids. (52.52.137)
- Amino acids are essential for the overall development of the body since they are building blocks of protein joined together by peptide bonds. (dietspotlight.com)
- These are available in the body as organic compounds that act as protein building blocks or free amino acids. (dietspotlight.com)
- The precise amino acid content, and the sequence of those amino acids, of a specific protein, is determined by the sequence of the bases in the gene that encodes that protein. (wikibooks.org)
- Before reaching skeletal muscle, dietary protein is digested into small peptides and free amino acids. (clinicaltrials.gov)
- As amino acid availability in the blood is a precursor for muscle protein synthesis, our objective is to determine if the different absorption rates between free amino acid and peptides influence muscle protein synthetic and breakdown rates. (clinicaltrials.gov)
- They will be given amino acid-based shakes and protein free cookies. (clinicaltrials.gov)
- FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. (genecards.org)
- The unique three-dimensional shape of each protein, which results from the linear sequence of amino acids, determines the protein's specific function in the body. (newworldencyclopedia.org)
- As the name "proteinogenic" (literally, protein building ) suggests, these amino acid are encoded by the standard genetic code and participate in the process of protein synthesis. (newworldencyclopedia.org)
- They are formed from an mRNA template in a process called translation, by which genetic information, encoded in the form of nucleic acids, is translated into the amino acids essential for protein synthesis. (newworldencyclopedia.org)
- Combinations of these amino acids produce every single protein required for the homeostasis (i.e., the maintenance of a stable internal environment) of the human body . (newworldencyclopedia.org)
- Sv-LAAOs are present in the acidic, basic, and neutral forms of the protein. (wikipedia.org)
- The book also details protein synthesis and degradation, regulation of amino acid metabolism, physiological functions of amino acids, and inborn errors of amino acid metabolism. (routledge.com)
- It covers the history, chemistry, and the integrated physiology of the major amino acids, going far beyond their use in protein synthesis to include a full description of non-protein functions and the role of amino acids as signaling molecules. (routledge.com)
- The 969-amino acid protein is a member of the Peptidase S8 family. (biocompare.com)
- Basic building block of protein molecules. (igi-global.com)
- When you eat protein, your body breaks the protein down into amino acids. (scientificamerican.com)
- Amino acids are the molecular building blocks of protein. (medicalnewstoday.com)
- However, thanks to advances made in recent decades, a more refined supplement has emerged to challenge the supremacy of traditional protein shakes and powders: amino acid supplements made with BCAAs. (amino-vital.com)
- Those who had a biology class in high school or college may recall that amino acids are the building blocks of protein. (amino-vital.com)
- however, amino acid supplements provide a number of advantages not found in traditional protein-based products. (amino-vital.com)
- For this reason, amino acid supplements require far less digestion than conventional protein supplements, allowing them to take effect up to three times faster than whey. (amino-vital.com)
- The second major advantage amino acid supplements have is that they're much leaner than a regular protein shake. (amino-vital.com)
- Amino acids are the structure squares of protein. (selfgrowth.com)
- Inside these hard seeds lie delicate, white or light green internal portions that are stuffed with fundamental amino acids, protein, and omega-3 unsaturated fats. (selfgrowth.com)
Histidine2
- Activation is also inhibited by alteration of the other two basic amino acid residues present, lysine and histidine. (biomedsearch.com)
- Histidine was thought to be nonessential for adults since it appeared that only infants could not synthesize it, but more extensive studies suggest that adults, too, rely upon dietary sources of this amino acid. (52.52.137)
Peptides6
- Amino acids and peptides (di- and tripeptides) as chemically bonded ligands in liquid chromatography were investigated. (springer.com)
- In the last decade, there have been several investigations of amino acids, peptides, and polypeptides grafted onto silica as stationary phases for liquid chromatography (LC). (springer.com)
- Rate of absorption from the intestine to the blood stream is significantly faster for peptides compared to amino acids. (clinicaltrials.gov)
- In the last half-century, there have been many conceptual and technical advancements, from analysis of amino acids by high-performance liquid chromatography and mass spectrometry to molecular cloning of transporters for amino acids and small peptides. (routledge.com)
- The intent of this investigation was to determine the effect of varying the side chain length of the basic amino acids residues on the binding of a series of antimicrobial peptides (AMPs) to zwitterionic and anionic LUVs, SUVs and micelles. (elsevier.com)
- Also provided are methods of preparing the peptides, as well as nucleic acid molecules encoding the peptides. (google.com)
Residues15
- The amino acid sequence of human gamma-trace, a basic microprotein without known function, was determined by automated Edman degradations of the carboxymethylated polypeptide chain and of fragments obtained by cyanogen bromide treatment and tryptic digestion after blocking of lysine residues. (pnas.org)
- A cluster of basic amino acid residues in calcineurin b participates in the binding of calcineurin to phosphatidylserine vesicles. (nih.gov)
- In the present study we tested the effects of mutations of calcineurin B subunit amino acid residues K(20)K(21), K(24)R(25), K(27)K(28) to Glu on the interactions between calcineurin and phosphatidylserine vesicles. (nih.gov)
- The effect of chemical modification of basic amino acid residues on the activation and amidolytic activity of Hageman factor (factor XII). (biomedsearch.com)
- In contrast, modification of amino group(s) in N-terminal and lysine residues inhibits activated Hageman factor. (biomedsearch.com)
- Thus, basic amino acid residues essential to the activation or activity of Hageman factor appear to be variably accessible to chemical modification. (biomedsearch.com)
- The switch from a low pathogenic avian influenza (LPAI) phenotype, common in wild birds and poultry, to the HPAI phenotype is achieved by the introduction of basic amino acid residues into the HA0 cleavage site (5). (thefreedictionary.com)
- lysine (K) replacement, which contains 6 basic amino acid residues KRRKKR, whereas all Thai isolates from 2003 and 2004 have RRRKKR. (thefreedictionary.com)
- The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. (genecards.org)
- These results showed that functional P. sojae PY-NLSs include an additional cluster of basic residues for efficient nuclear import. (frontiersin.org)
- Various attempts have been made to identify the amino acid residues of ASP that are important for binding. (google.com)
- Escherichia coli heat-stable enterotoxin II (STII) is composed of 48 amino acid residues. (elsevier.com)
- Isoelectric focusing showed that the isoelectric point of STII is 9.7, indicating that the side chains of some of these basic amino acid residues project outside the molecule. (elsevier.com)
- This indicated that lysine residues play an important role in the expression of the enterotoxic activity of STII and that the contribution of the other basic amino acid residues to the toxicity is relatively low. (elsevier.com)
- To confirm this hypothesis, we substituted these nine basic amino acid residues by oligonucleotide-directed site- specific mutagenesis and examined the enterotoxicity of these purified mutant STIIs. (elsevier.com)
Glycine2
- The HA gene of KU-02 and KU-03 contained multiple basic amino acid insertions at the HA cleavage site (SPQRERRRKKRR) as well as glutamine and glycine (Q222-G224) at the receptor binding site. (thefreedictionary.com)
- REFECT AND APPLY Could the amino acid glycine serve as the ba- sis of a buffer system? (bartleby.com)
Alanine1
- One example of the enzyme in action occurs with the conversion L-alanine into pyruvic acid (2-oxopropanoic acid), as shown in Figure 1. (wikipedia.org)
Paired Basic Amino Acid Cleaving Enzyme4
- Purification and Characterization of Recombinant Human Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4). (thefreedictionary.com)
- Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4) is a eukaryotic endoprotease in the subtilisin-like proprotein convertase (SPC) family. (thefreedictionary.com)
- Paired Basic Amino Acid Cleaving Enzyme 4 (PACE4) is a member of the SPC family that has been implicated in a number of proprotein processing events important in mammalian development, homeostasis, and pathology. (thefreedictionary.com)
- Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme). (creativebiomart.net)
Methionine5
- Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG. (pnas.org)
- Results of the amino acid analysis revealed high contents of the essential amino acids with methionine as the limiting amino acid. (ajol.info)
- They found that restricting the amount of an amino acid called methionine in the flies' food had the desired effect. (medicalnewstoday.com)
- Methionine, which is abundant in meat and eggs, is known as an "essential" amino acid because the body cannot make its own. (medicalnewstoday.com)
- By eliminating one essential amino acid at a time from the diet of fly larvae, they discovered that depriving the larvae of methionine shut down the P38 pathway. (medicalnewstoday.com)
Types of amino acids3
- However, you will find recommended food sources for different types of amino acids (including branched chain, sulfur-containing, aromatic, and others) in the Summary of Food Sources section of this article. (whfoods.org)
- After the extensive review, scientists are able to identify two types of amino acids: proteinogenic and nonproteinogenic. (dietspotlight.com)
- There are many different types of amino acids. (medlineplus.gov)
Glucogenic amino2
- What are ketogenic and glucogenic amino acids? (reference.com)
- The Glucogenic Amino Acids are a vital source of energy in the absence of carbohydrates and during fasting. (colloidsforlife.com)
Carboxylic9
- If you remember nothing alcohols (ser and thre) sulphydryls (cys) amines (lys and N-terminals), carboxylic acids, amides, paraffins rapidly refresh them. (physicsforums.com)
- Chemically, an amino acid contains an amino group (with a nitrogen atom) and a carboxylic acid functional group. (52.52.137)
- Amino acids are molecules which contain both a carboxylic acid and an amine group. (wikibooks.org)
- In amino acid, the carboxyl group is more acidic than the carboxylic acid. (wikibooks.org)
- An amino acid is in a zwitterionic state when the carboxylic acid group is deprotonated and the amino group is protonated, simultaneously. (wikibooks.org)
- In solid state, the amine functionality deprotonates the carboxylic acid group, giving rise to the zwitterionic, dipolar entity. (wikibooks.org)
- The amino group is on the left, and the carboxylic acid group is on the right. (newworldencyclopedia.org)
- An amino acid is an organic molecule with three main components: an amino group (-NH2), a carboxylic acid group (-COOH), and an R group, or side chain, unique to each amino acid. (newworldencyclopedia.org)
- Carboxylic acids and their derivatives: esters and amides. (unimi.it)
Individual amino3
- Part of the difficulty in determining our need for individual amino acids involves the interconversion of amino acids that is constantly taking place in our body. (whfoods.org)
- There are several types of methods used to determine the individual amino acid levels in the blood. (medlineplus.gov)
- Increased levels of individual amino acids can be a sign of a problem with metabolism. (medlineplus.gov)
Neutral8
- Involved in the high-affinity sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). (uniprot.org)
- 2) Isotopic average of neutral amino acyl residu in a peptide bond. (genosphere-biotech.com)
- Thomas B. Kinraide and Bud Etherton 1980-06-01 00:00:00 The application of neutral or acidic amino acids to oat coleptiles induced transient depolarizations of the membrane potentials. (deepdyve.com)
- These experiments support the co-transport theory but suggest somewhat different mechanisms for the transport of the neutral, acidic, and basic amino acids. (deepdyve.com)
- We suggest that the neutral amino acids are co-transported with a single H + and that accumulation depends upon both the ΔpH and the membrane potential components of the proton motive force. (deepdyve.com)
- The application of neutral or acidic amino acids to oat coleptiles induced transient depolarizations of the membrane potentials. (deepdyve.com)
- 2.A.3.8.7 y+LAT1 (transports neutral amino acids (i.e. (tcdb.org)
- Both a protoplast amino acid uptake assay and HPLC analysis indicated that more basic (Lys, Arg) and neutral (Val, Ala) amino acids were transported and accumulated in the OE lines than in the wild type, but the opposite was observed in the RNAi lines. (plantphysiol.org)
Cysteine2
- Working with genetically engineered mice, Johns Hopkins neuroscientists report they have identified what they believe is the cause of the vast disintegration of a part of the brain called the corpus striatum in rodents and people with Huntington's disease: loss of the ability to make the amino acid cysteine. (hopkinsmedicine.org)
- Bindu Diana Paul, Ph.D., a molecular neuroscientist and faculty instructor in Snyder's laboratory, was studying mice lacking CSE, which helps make the amino acid cysteine and hydrogen sulfide that moderate blood pressure and heart function. (hopkinsmedicine.org)
Ornithine2
- A unique blend of 20 highest quality L-Crystalline singular amino acids, plus precursor Ornithine-Þ-Ketoglutarate and the superior antioxidant protection of Alpha Lipoic Acid for general health support. (forresthealth.com)
- Plus precursor Ornithine-Þ-Ketoglutarate and the superior antioxidant protection of Alpha Lipoic Acid for general health support. (forresthealth.com)
GLUTAMIC ACID2
- GLUTAMIC ACID important for neurological health and is precursor to GABA. (forresthealth.com)
- Although the cleavage site adjacent to the fusion peptide is typically a basic amino acid , the reported Angrem52 cDNA sequence has an acidic glutamic acid at this position (Figure 1B). (thefreedictionary.com)
Nitrogen8
- It is a major carbon and nitrogen donor, and it contributes to the formation of other amino acids, nucleotides and the anti-oxidant GSH. (uio.no)
- Product Description Amino Acid organic fertilizer A new type of organic nitrogen fertilizer it s efficient and green fertilizer and made from residue of monosodium glutamate after pressing through using advanced production equipment to granulate it under high temperature It provides organic matter. (sinochemnutrition.com)
- Carbon, Hydrogen, Oxygen, and Nitrogen are the main elements that make up amino acids although the side chain may feature a variety of other elements. (dietspotlight.com)
- Interestingly, although alcohols and amines can be Brønsted-Lowry acids, they can also function as Lewis bases due to the lone pairs of electrons on their oxygen and nitrogen atoms. (wikipedia.org)
- Plants synthesize the amino acids that they require, utilizing carbon and oxygen from the air, hydrogen from water, and nitrogen that has been converted to usable form through nitrogen fixation . (newworldencyclopedia.org)
- Amino acids reflect the interconnectedness of life, as the non-ruminant animals depend of plants for essential amino acids, ruminants depend on microbes within as a source, and even plants depend on bacteria to fix the nitrogen into a form that they can utilize to produce amino acids. (newworldencyclopedia.org)
- Amino acids are regarded as the nitrogen 'currency' of plants. (nih.gov)
- Amino acids can be taken up from the soil directly or synthesized from inorganic nitrogen, and then circulated in the plant via phloem and xylem. (nih.gov)
Polypeptides4
- Amino Acids form short polymer chains called â€Å"peptides†, longer chains are called polypeptides. (colloidsforlife.com)
- The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. (osti.gov)
- The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methyltrophic yeast such as Pichia pastoris. (osti.gov)
- Methods for producing polypeptides comprising unnatural amino acids in methyltrophic yeast such as Pichia pastoris are also provided. (osti.gov)
Hydrogen11
- When a basic amino acid is in an acidic medium (having a pH lower than 7 and containing the hydrogen ion [H. (thefreedictionary.com)
- Acids are the compounds that donate a hydrogen ion (H+) to a base, while a base compound is one that can remove a proton (H+ is a proton) from an acid. (aminoco.com)
- Hydrogen molecules are why bases and acids are often measured in pH levels (pH stands for "potential of hydrogen") as related to pure water. (aminoco.com)
- When an acid is dissolved in water, it becomes a solution with higher hydrogen ion activity than water, making it more acidic, with a pH value less than 7. (aminoco.com)
- Weak acids include formic acid, acetic acid, hydrofluoric acid, hydrogen sulfide and hydrocyanic acid. (reference.com)
- Each of these acids has the same basic chemical structure, which includes a central carbon atom, a hydrogen atom, a group of atoms called an amino group and a group of atoms called a carboxyl group. (livestrong.com)
- In an aqueous environment, the hydrophobic amino acids are unable to participate in hydrogen bonding. (wikibooks.org)
- An acid is a molecule or ion capable of donating a hydron (proton or hydrogen ion H + ), or, alternatively, capable of forming a covalent bond with an electron pair (a Lewis acid). (wikipedia.org)
- Common aqueous acids include hydrochloric acid (a solution of hydrogen chloride which is found in gastric acid in the stomach and activates digestive enzymes ), acetic acid (vinegar is a dilute aqueous solution of this liquid), sulfuric acid (used in car batteries ), and citric acid (found in citrus fruits). (wikipedia.org)
- However, hydrogen chloride, acetic acid, and most other Brønsted-Lowry acids cannot form a covalent bond with an electron pair and are therefore not Lewis acids. (wikipedia.org)
- The three substrates of the enzymatic reaction are an L-amino acid, water, and oxygen, whereas the three products are the corresponding α-keto acid (2-oxo acid), ammonia, and hydrogen peroxide. (wikipedia.org)
Specific amino acid1
- Often they produce higher than normal amounts of the corresponding natural amino acids, and, hence, growth in specific amino acid analog is used as a selection tool (1). (springer.com)
Chemical11
- Name, Abbreviations, Chemical classification, Relative Abundance, and Acid-Base properties of each of the natural amino acidsAmino acid. (genosphere-biotech.com)
- The distinguishing characteristic of each amino acid is a portion of its structure called a side chain or R-group, which has a unique chemical arrangement. (livestrong.com)
- In addition, each amino acid contains a unique side group that features an element or chemical structure which imparts a specific characteristic or function to that amino acid. (52.52.137)
- The performed research assisted in the evaluation of the relation between the chemical properties of bonded amino acid sequence and their role in the retention mechanism. (springer.com)
- Amino acids can be broadly hydrophobic and hydrophilic , depending on the chemical properties of the R group side chain. (wikibooks.org)
- Lewis considered this as a generalization of the Brønsted definition, so that an acid is a chemical species that accepts electron pairs either directly or by releasing protons (H + ) into the solution, which then accept electron pairs. (wikipedia.org)
- Modern definitions are concerned with the fundamental chemical reactions common to all acids. (wikipedia.org)
- Chemical structures of the 20 standard amino acids. (newworldencyclopedia.org)
- In enzymology, an L-amino acid oxidase (LAAO) (EC 1.4.3.2) is an enzyme that catalyzes the chemical reaction an L-amino acid + H2O + O2 ⇌ {\displaystyle \rightleftharpoons } a 2-oxo acid + NH3 + H2O2 The enzyme was first described in 1944 by A. Zeller and A. Maritz. (wikipedia.org)
- Although chemical labeling methods such as ICAT (isotope-coded affinity tags) have demonstrated widespread applicability ( 1 ), metabolic incorporation strategies such as stable isotope labeling with amino acids in cell culture (SILAC) are becoming more common for cell types that can be grown for extensive periods of time in vitro . (mcponline.org)
- Though there are numerous advantages for using SILAC-based methods, compared with chemical labeling, a major drawback is the unintended metabolic inter-conversion of isotopic amino acids in the labeling process, generating artifacts affecting the quantification. (mcponline.org)
Hydrophobic3
- In the case of HILIC mode, the characterization was performed in terms of the degree of hydrophilicity, selectivity for hydrophilic-hydrophobic compounds, selectivity for the regio and configurational substituents, anion and cation exchange properties, and acidic or basic nature of the stationary phase surface. (springer.com)
- Many studies show that a number of sv-LAAOs exhibit a preference for hydrophobic L-amino acids as substrates. (wikipedia.org)
- For example, results have indicated that most sv-LAAOs demonstrate relatively high specificities toward hydrophobic amino acids such as L-Met, L-Leu, and L-Ile in addition to aromatic amino acids such as L-Phe and L-Trp. (wikipedia.org)
Tyrosine1
- Iodinated and brominated tyrosine are also amino acids found in species, but are not included in the 20 major amino acids because of their rarity: iodinated tyrosin is only found in thyroid hormones, and brominated tyrosine is only found in coral. (wikibooks.org)
Glutamine5
- Amino acids, and in particular glutamine, are involved in a variety of metabolic pathways. (uio.no)
- Glutamine is the most abundant amino acid in the serum and cerebrospinal fluid. (uio.no)
- We investigate molecular mechanisms involved in glutamine (and other amino acids) transport across cell membranes subsequent metabolism of glutamine in order to reveal its (patho-)functional roles in brain development and function (e.g. synaptic plasticity, epilepsy, dementia, hepatic encephalopathy and diabetes). (uio.no)
- Is glutamine a basic amino acid? (healthtap.com)
- Huntington's disease, an inherited disorder, does its damage because of abnormal DNA coding for the amino acid glutamine. (hopkinsmedicine.org)
Synthesis3
- Overall good nutrition is important as well, since sub-optimal vitamin and mineral status can interfere with the synthesis of nonessential amino acids by impairing enzymes or other cofactors involved in the reaction. (52.52.137)
- Additional chapters cover cell-, tissue-, and species-specific synthesis and catabolism of amino acids and related nitrogenous substances, as well as the use of isotopes to study amino acid metabolism in cells and the body. (routledge.com)
- Used in synthesis of polymeric polylactic acid (polylactide, polylactate) plastic. (canstockphoto.com)
Unnatural amino acids1
- These AMPs are based on the incorporation of three dipeptide units consisting of the unnatural amino acids Tic-Oic in the sequence, Ac-GF-Tic-Oic-GX-Tic-Oic-GF-Tic-Oic-GX-Tic-XXXX-CONH 2 , where X (Spacer #2) may be one of the following amino acids, Lys, Orn, Dab, Dpr or Arg. (elsevier.com)
Biochemistry3
- In biochemistry, an amino acid is a molecule containing both amine and carboxyl functional groups. (colloidsforlife.com)
- Amino Acids: Biochemistry and Nutrition presents comprehensive coverage of these scientific developments, providing a useful reference for students and researchers in both biomedicine and agriculture. (routledge.com)
- While emphasizing basic principles and classical concepts of amino acid biochemistry and nutrition, the author includes recent progress in the field. (routledge.com)
ASPARTIC ACID1
- ASPARTIC ACID helps in protective function and detoxification of the liver. (forresthealth.com)
Characterization of Amino Acid1
- J.M. Widholm, Selection and characterization of amino acid analog resistant plant cell cultures, Crop Sci. (springer.com)
Chemically1
- Shorter sequences of amino acids (i.e. di-, tri-, and tetrapeptides) were also investigated with regard to chemically bonded stationary phases for LC. (springer.com)
Essential17
- Comparing its essential amino acids with the WHO recommended values, the vegetable is adequate in these acids. (ajol.info)
- Your essential amino acids are the ones you need but cannot produce yourself, and so must be gained either from your diet or via supplementation. (aminoco.com)
- All Amino Acids become â€Å"essential aminos†when our body does not make it when we need it. (colloidsforlife.com)
- Amino acids are essential to life, have a role in metabolism and are important in nutrition. (colloidsforlife.com)
- Here is an overview of basic information about amino acids and how and why they are perfectly suited for, and in fact "essential" to, the dietary goals of people committed to health and their own well-being. (52.52.137)
- Nine amino acids must be obtained from food sources or supplements since humans do not have the ability to make them, and these are deemed indispensable or essential . (52.52.137)
- There is a recommended dietary allowance (RDA) for the essential amino acids while there is no required dietary intake defined for the nonessentials. (52.52.137)
- There are also some conditionally essential amino acids . (52.52.137)
- Liver damage impairs the conversion of some essential amino acids to nonessential amino acids, and these nonessentials then become classified as conditionally essential amino acids. (52.52.137)
- Other amino acids can be regenerated into ketones, which is essential to the brain in case you abstain from food or have a diet that is low in carbohydrates. (dietspotlight.com)
- Those important amino acids that cannot be synthesized by an animal, or at a rate sufficient to meet its physiological needs, and which therefore must be obtained from the diet, are called essential amino acids . (newworldencyclopedia.org)
- The essential amino acids vary according to the type of animal. (newworldencyclopedia.org)
- Approximately half of these standard amino acids are considered essential amino acids that cannot be synthesized and must be obtained from food. (newworldencyclopedia.org)
- Thus, the number of essential amino acids in humans is variously listed as 8 or 10. (newworldencyclopedia.org)
- In a recent study using fruit flies, researchers showed that depriving flies of an essential amino acid can turn off an oncogene's growth pathway while keeping its death pathway switched on. (medicalnewstoday.com)
- the others - called the "essential" amino acids - must be obtained from supplements or food. (amino-vital.com)
- Among these essential compounds is a group of three amino acids with a distinctive shape and an outsize role in supporting athletic performance: the branched-chain amino acids, more commonly known as BCAAs. (amino-vital.com)
Proteinogenic amino2
- The â€Å"Non-proteinogenic amino acids†(like carnitine, GABA, or Carnosine) are not coded or not used in the standard genetic code. (colloidsforlife.com)
- In humans , 20 amino acids are known as standard amino acids or proteinogenic amino acids. (newworldencyclopedia.org)
Transports basic amino acids2
- The Arabidopsis nuclear gene BASIC AMINO ACID CARRIER 2 ( BAC2 ) encodes a mitochondria-located carrier that transports basic amino acids in vitro . (frontiersin.org)
- transports basic amino acids (i.e. (tcdb.org)
Transporters2
- The intracellular localization suggests trafficking or cycling of the transporter, similar to many metabolite transporters in yeast or mammals, for example, yeast amino acid permease GAP1. (nih.gov)
- Microarray analyses revealed that the expression profile of genes involved in amino acid metabolism did not change drastically, indicating potential compensation by other amino acid transporters. (nih.gov)
Enzymes2
- For this reason, there is need to understand why amino acids are important, how they are broken down by enzymes, their benefits, and side effects. (dietspotlight.com)
- Several mechanisms can give rise to analog resistance, but most recovered variants appear to possess altered amino acid levels caused by changes in regulatory enzymes resulting in relaxed feed back control (1, 2). (springer.com)
Sequence of amino acids2
- Depending on the immobilized sequence of amino acids, these materials exhibit diversified application targets. (springer.com)
- A codon table can be used to translate a genetic code into a sequence of amino acids . (wikipedia.org)
Metabolism of amino acids2
- Defects in metabolism of amino acids. (medlineplus.gov)
- This useful volume takes a broad-based look at the metabolism of amino acids. (routledge.com)
Fatty acids5
- Also known as fatty Acids) are a nutrient that gives us energy, insulates us from the cold, protects our nerves and cushions our organs against impact. (freewebs.com)
- April 4th - New research led by Harvard T.H. Chan School of Public Health has identified numerous genes that influence how cells respond to saturated fatty acids. (harvard.edu)
- Examples: oils, fatty acids (i.e. the 'tails' of phospholipids), cholesterol. (wikibooks.org)
- Fatty acids and their structure. (unimi.it)
- Catabolism and biosynthesis of fatty acids. (unimi.it)
Supplements3
- You may already be familiar with some of these amino acids since an increasing number are available as nutritional supplements. (52.52.137)
- Are Amino Acid BCAA Supplements Good for Swimmers? (amino-vital.com)
- For instance, amino acid supplements are a newer, more advanced form of fitness supplement that has gained quite a following in recent years, but are amino acids and BCAA supplements good for swimmers? (amino-vital.com)
Nucleic acid1
- As multiple codons can code for the same amino acid, the International Union of Pure and Applied Chemistry 's (IUPAC) nucleic acid notation is given in some instances. (wikipedia.org)
Acidic amino1
- The acidic amino acids appear to be accumulated by a similar mechanism except that the transport of each molecule may be associated with a cation in addition to a single proton. (deepdyve.com)
Bcaa3
- This study will evaluate the branched-chain amino acids (BCAA) ratio in the medical foods formulated for Methylmalonic and Propionic Acidemias (MMA/PROP) patients. (clinicaltrials.gov)
- Different Branched-chain amino acid (BCAA) ratios will be tested. (clinicaltrials.gov)
- 6 different ratios of the Branched-chain Amino Acids (BCAA) will be tested for 8 hours each. (clinicaltrials.gov)
Major amino acids1
- The 20 major amino acids, along with hundreds of other minor amino acids, sustain our lives. (wikibooks.org)
Nonessential amino acids3
- Your nonessential amino acids are the amino acids your body can create on its own as a byproduct of normal functioning. (aminoco.com)
- While in theory, we could function perfectly well without any dietary intake of nonessential amino acids, we are actually much more metabolically efficient if we have some percentage of these amino acids supplied by the diet. (52.52.137)
- For example, with an illness or a catabolic disease , having an abundance of all amino acids facilitates immune system function by ensuring all the amino acid components are available and energy does not need to be devoted to synthesizing nonessential amino acids. (52.52.137)
PROLINE1
- PROLINE is major amino acid found in cartilage and is important for maintaining youthful skin as well as repair of muscle, connective tissue and skin damage. (forresthealth.com)
Permease2
- All but one of thirty mutants were allelic, and were specifically deficient in the basic amino acid permease. (genetics.org)
- AtAAP3, a member of the Amino Acid Permease (AAP) family, is mainly expressed in root tissue, suggesting a potential role in the uptake and distribution of amino acids. (nih.gov)