AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Amino Acid Transport System ASCAmino Acid Transport SystemsAmino Acid Transport System LAmino AcidsAmino Acid Transport Systems, BasicAminoisobutyric AcidsBiological TransportAmino Acid Transport System AAmino Acid Transport Systems, NeutralBiological Transport, ActiveLeucineAmino Acid Transport System y+HarmalineAlaninebeta-AlanineSodiumAntigens, CD98Amino Acids, NeutralAmino Acids, CyclicAmino Acids, Branched-ChainCarrier ProteinsKineticsPhenylalanineAmino Acid Transport System y+LMembrane Transport Proteins4-ChloromercuribenzenesulfonateGlutamineProlineCystineIsoleucineFatty Acid Transport ProteinsValineAmino Acid SequenceArginineLysineLeucine-tRNA LigaseCloning, MolecularMutationCell MembraneAmino Acid Transport Systems, AcidicMolecular Sequence DataSequence Homology, Amino AcidHydrogen-Ion ConcentrationTryptophanEscherichia coliGlutamatesXenopus laevisSubstrate SpecificityOocytesHistidineThreonineBase SequenceCell LineTaurocholic AcidDicarboxylic AcidsRats, Inbred StrainsRNA, MessengerBacterial ProteinsEthylmaleimideLarge Neutral Amino Acid-Transporter 1Cells, Cultured
Amino Acid Transport System ASC
A ubiquitous sodium-dependent neutral amino acid transporter. The preferred substrates for this transporter system include ALANINE; SERINE; and CYSTEINE.
Amino Acid Transport Systems
Cellular proteins and protein complexes that transport amino acids across biological membranes.
Amino Acid Transport System L
A sodium-independent neutral amino acid transporter system with specificity for large amino acids. One of the functions of the transporter system is to supply large neutral amino acids to the brain.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Amino Acid Transport Systems, Basic
Amino acid transporter systems capable of transporting basic amino acids (AMINO ACIDS, BASIC).
Aminoisobutyric Acids
A group of compounds that are derivatives of the amino acid 2-amino-2-methylpropanoic acid.
Biological Transport
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Amino Acid Transport System A
A sodium-dependent neutral amino acid transporter that accounts for most of the sodium-dependent neutral amino acid uptake by mammalian cells. The preferred substrates for this transporter system include ALANINE; SERINE; and GLUTAMINE.
Amino Acid Transport Systems, Neutral
Amino acid transporter systems capable of transporting neutral amino acids (AMINO ACIDS, NEUTRAL).
Biological Transport, Active
The movement of materials across cell membranes and epithelial layers against an electrochemical gradient, requiring the expenditure of metabolic energy.
Leucine
An essential branched-chain amino acid important for hemoglobin formation.
Amino Acid Transport System y+
Harmaline
A beta-carboline alkaloid isolated from seeds of PEGANUM.
Alanine
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
beta-Alanine
An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
Sodium
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Amino Acids, Neutral
Amino acids with uncharged R groups or side chains.
Amino Acids, Cyclic
A class of amino acids characterized by a closed ring structure.
Amino Acids, Branched-Chain
Amino acids which have a branched carbon chain.
Carrier Proteins
Transport proteins that carry specific substances in the blood or across cell membranes.
Kinetics
The rate dynamics in chemical or physical systems.
Phenylalanine
An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
Amino Acid Transport System y+L
Membrane Transport Proteins
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
4-Chloromercuribenzenesulfonate
A cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.
Glutamine
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
Proline
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Cystine
A covalently linked dimeric nonessential amino acid formed by the oxidation of CYSTEINE. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.
Isoleucine
An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.
Fatty Acid Transport Proteins
A broad category of membrane transport proteins that specifically transport FREE FATTY ACIDS across cellular membranes. They play an important role in LIPID METABOLISM in CELLS that utilize free fatty acids as an energy source.
Valine
A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Arginine
An essential amino acid that is physiologically active in the L-form.
Lysine
An essential amino acid. It is often added to animal feed.
Leucine-tRNA Ligase
An enzyme that activates leucine with its specific transfer RNA. EC 6.1.1.4.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Amino Acid Transport Systems, Acidic
Amino acid transporter systems capable of transporting acidic amino acids (AMINO ACIDS, ACIDIC).
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sequence Homology, Amino Acid
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
Hydrogen-Ion Concentration
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Glutamates
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
Xenopus laevis
The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.
Substrate Specificity
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Oocytes
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Histidine
An essential amino acid that is required for the production of HISTAMINE.
Threonine
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Taurocholic Acid
The product of conjugation of cholic acid with taurine. Its sodium salt is the chief ingredient of the bile of carnivorous animals. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and cholerectic.
Dicarboxylic Acids
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Bacterial Proteins
Proteins found in any species of bacterium.
Ethylmaleimide
A sulfhydryl reagent that is widely used in experimental biochemical studies.
Large Neutral Amino Acid-Transporter 1
A CD98 antigen light chain that when heterodimerized with CD98 antigen heavy chain (ANTIGENS, CD98 HEAVY CHAIN) forms a protein that mediates sodium-independent L-type amino acid transport.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. (1/71)

The RD114/simian type D retroviruses, which include the feline endogenous retrovirus RD114, all strains of simian immunosuppressive type D retroviruses, the avian reticuloendotheliosis group including spleen necrosis virus, and baboon endogenous virus, use a common cell-surface receptor for cell entry. We have used a retroviral cDNA library approach, involving transfer and expression of cDNAs from highly infectable HeLa cells to nonpermissive NIH 3T3 mouse cells, to clone and identify this receptor. The cloned cDNA, denoted RDR, is an allele of the previously cloned neutral amino acid transporter ATB0 (SLC1A5). Both RDR and ATB0 serve as retrovirus receptors and both show specific transport of neutral amino acids. We have localized the receptor by radiation hybrid mapping to a region of about 500-kb pairs on the long arm of human chromosome 19 at q13.3. Infection of cells with RD114/type D retroviruses results in impaired amino acid transport, suggesting a mechanism for virus toxicity and immunosuppression. The identification and functional characterization of this retrovirus receptor provide insight into the retrovirus life cycle and pathogenesis and will be an important tool for optimization of gene therapy using vectors derived from RD114/type D retroviruses.  (+info)

A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. (2/71)

The type D simian retroviruses cause immunosuppression in macaques and have been reported as a presumptive opportunistic infection in a patient with AIDS. Previous evidence based on viral interference has strongly suggested that the type D simian viruses share a common but unknown cell surface receptor with three type C viruses: feline endogenous virus (RD114), baboon endogenous virus, and avian reticuloendotheliosis virus. Furthermore, the receptor gene for these viruses has been mapped to human chromosome 19q13.1-13.2. We now report the isolation and characterization of a cell surface receptor for this group of retroviruses by using a human T-lymphocyte cDNA library in a retroviral vector. Swiss mouse fibroblasts (NIH 3T3), which are naturally resistant to RD114, were transduced with the retroviral library and then challenged with an RD114-pseudotyped virus containing a dominant selectable gene for puromycin resistance. Puromycin selection yielded 12 cellular clones that were highly susceptible to a beta-galactosidase-encoding lacZ(RD114) pseudotype virus. Using PCR primers specific for vector sequences, we amplified a common 2.9-kb product from 10 positive clones. Expression of the 2.9-kb cDNA in Chinese hamster ovary cells conferred susceptibility to RD114, baboon endogenous virus, and the type D simian retroviruses. The 2.9-kb cDNA predicted a protein of 541 amino acids that had 98% identity with the previously cloned human Na+-dependent neutral-amino-acid transporter Bo. Accordingly, expression of the RD114 receptor in NIH 3T3 cells resulted in enhanced cellular uptake of L-[3H]alanine and L-[3H]glutamine. RNA blot (Northern) analysis suggested that the RD114 receptor is widely expressed in human tissues and cell lines, including hematopoietic cells. The human Bo transporter gene has been previously mapped to 19q13.3, which is closely linked to the gene locus of the RD114 receptor.  (+info)

Na+ - and Cl- -coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B(0,+). (3/71)

Nitric oxide synthase (NOS) inhibitors have therapeutic potential in the management of numerous conditions in which NO overproduction plays a critical role. Identification of transport systems in the intestine that can mediate the uptake of NOS inhibitors is important to assess the oral bioavailability and therapeutic efficacy of these potential drugs. Here, we have cloned the Na+ - and Cl- -coupled amino acid transport system B(0,+) (ATB(0,+)) from the mouse colon and investigated its ability to transport NOS inhibitors. When expressed in mammalian cells, ATB(0,+) can transport a variety of zwitterionic and cationic amino acids in a Na+ - and Cl- -coupled manner. Each of the NOS inhibitors tested compete with glycine for uptake through this transport system. Furthermore, using a tritiated analog of the NOS inhibitor N(G)-nitro-L-arginine, we showed that Na+ - and Cl- -coupled transport occurs via ATB(0,+). We then studied transport of a wide variety of NOS inhibitors in Xenopus laevis oocytes expressing the cloned ATB(0,+) and found that ATB(0,+) can transport a broad range of zwitterionic or cationic NOS inhibitors. These data represent the first identification of an ion gradient-driven transport system for NOS inhibitors in the intestinal tract.  (+info)

Na+- and Cl--coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes. (4/71)

1. ATB(0,+) is an amino acid transporter energized by transmembrane gradients of Na+ and Cl(-) and membrane potential. We cloned this transporter from mouse colon and expressed the clone functionally in mammalian (human retinal pigment epithelial, HRPE) cells and Xenopus laevis oocytes to investigate the interaction of carnitine and its acyl esters with the transporter. 2. When expressed in mammalian cells, the cloned ATB(0,+) was able to transport carnitine, propionylcarnitine and acetylcarnitine. The transport process was Na(+) and Cl(-) dependent and inhibitable by the amino acid substrates of the transporter. The Michaelis constant for carnitine was 0.83 +/- 0.08 mM and the Hill coefficient for Na(+) activation was 1.6 +/- 0.1. 3. When expressed in Xenopus laevis oocytes, the cloned ATB(0,+) was able to induce inward currents in the presence of carnitine and propionylcarnitine under voltage-clamped conditions. There was no detectable current in the presence of acetylcarnitine. Carnitine-induced currents were obligatorily dependent on the presence of Na(+) and Cl(-). The currents were saturable with carnitine and the Michaelis constant was 1.8 +/- 0.4 mM. The analysis of Na(+)- and Cl(-)-activation kinetics revealed that 2 Na(+) and 1 Cl(-) were involved in the transport of carnitine via the transporter. 4. These studies describe the identification of a novel function for the amino acid transporter ATB(0,+). Since this transporter is expressed in the intestinal tract, lung and mammary gland, it is likely to play a significant role in the handling of carnitine in these tissues. 5. A Na(+)-dependent transport system for carnitine has already been described. This transporter, known as OCTN2 (novel organic cation transporter 2), is expressed in most tissues and transports carnitine with high affinity. It is energized, however, only by a Na(+) gradient and membrane potential. In contrast, ATB(0,+) is a low-affinity transporter for carnitine, but exhibits much higher concentrative capacity than OCTN2 because of its energization by transmembrane gradients of Na(+) and Cl(-) as well as by membrane potential.  (+info)

Na(+)-dependent neutral amino acid transporter ATB(0) is a rabbit epithelial cell brush-border protein. (5/71)

System B(0) activity accounts for the majority of intestinal and kidney luminal neutral amino acid absorption. An amino acid transport system, called ATB(0) (also known as ASCT2), with functional characteristics similar to those of system B(0), has been recently cloned. We generated polyclonal antibodies to human and rabbit ATB(0) COOH-terminal peptides and used Western blot analysis to detect ATB(0) protein in rabbit tissues, rabbit ileal brush-border membrane vesicles (BBMV), and HeLa cells transfected with plasmids containing ATB(0) cDNAs. Immunohistochemistry was used to localize ATB(0) in rabbit kidney and intestine. In Western blots of rabbit tissues, ATB(0) was a broad smear of 78- to 85-kDa proteins. In transfected HeLa cells, ATB(0) appeared as a smear consisting of 57- to 65-kDa proteins. The highest expression was found in the kidney. ATB(0) was enriched in rabbit ileal BBMV and in HeLa cells transfected with ATB(0) cDNAs. In the kidney and in the intestine, ATB(0) was confined to the brush-border membrane (BBM) of the proximal tubular cell and of the enterocyte, respectively. Tissue and intracellular distribution of ATB(0) protein parallels that of system B(0) activity. ATB(0) protein could be the transporter responsible for system B(0) in the BBM of epithelial cells.  (+info)

Sustained multilineage gene persistence and expression in dogs transplanted with CD34(+) marrow cells transduced by RD114-pseudotype oncoretrovirus vectors. (6/71)

Previous studies have shown that the choice of envelope protein (pseudotype) can have a significant effect on the efficiency of retroviral gene transfer into hematopoietic stem cells. This study used a competitive repopulation assay in the dog model to evaluate oncoretroviral vectors carrying the envelope protein of the endogenous feline virus, RD114. CD34-enriched marrow cells were divided into equal aliquots and transduced with vectors produced by the RD114-pseudotype packaging cells FLYRD (LgGLSN and LNX) or by the gibbon ape leukemia virus (GALV)-pseudotype packaging cells PG13 (LNY). A total of 5 dogs were studied. One dog died because of infection before sustained engraftment could be achieved, and monitoring was discontinued after 9 months in another animal that had very low overall gene-marking levels. The 3 remaining animals are alive with follow-ups at 11, 22, and 23 months. Analyses of gene marking frequencies in peripheral blood and marrow by polymerase chain reaction revealed no significant differences between the RD114 and GALV-pseudotype vectors. The LgGLSN vector also contained the enhanced green fluorescent protein (GFP), enabling us to monitor proviral expression by flow cytometry. Up to 10% of peripheral blood cells expressed GFP shortly after transplantation and approximately 6% after the longest follow-up of 23 months. Flow cytometric analysis of hematopoietic subpopulations showed that most of the GFP-expressing cells were granulocytes, although GFP-positive lymphocytes and monocytes were also detected. In summary, these results show that RD114-pseudotype oncoretroviral vectors are able to transduce hematopoietic long-term repopulating cells and, thus, may be useful for human stem cell gene therapy.  (+info)

ATB(0)/SLC1A5 gene. Fine localisation and exclusion of association with the intestinal phenotype of cystic fibrosis. (7/71)

The Na+-dependent amino acid transporter named ATB(0) was previously found to be located in 19q13.3 by fluorescence in situ hybridisation. Genetic heterogeneity in the 19q13.2-13.4 region, syntenic to the Cystic Fibrosis Modulator Locus 1 (CFM1) in mouse, seemed to be associated to the intestinal phenotypic variation of cystic fibrosis (CF). We performed fine chromosomal mapping of ATB(0) on radiation hybrid (RH) panels G3 and TNG. Based on the most accurate location results from TNG-RH panel, mapping analysis evidenced that ATB(0) is localised between STS SHGC-13875 (D19S995) and STS SHGC-6138 in 19q13.3, that corresponds with the immediately telomeric/distal segment of the strongest linkage region within the human CFM1 (hCFM1) syntenic region. Regarding to the genomic structure and exon organisation, our results show that the ATB(0) gene is organised into eight exons. The knowledge of the genomic structure allowed us to perform an exhaustive mutational analysis of the gene. Evaluation of the possible implication of ATB(0) in the intestinal phenotype of CF was performed on the basis of the functional characteristics of the encoded protein, its apparent relevance to meconium ileus (MI) and position in relation to the hCFM1 syntenic region. We have analysed this gene in samples from CF patients with and without MI. Several sequence variations in the ATB(0) gene were identified, although none of them seemed to be related to the intestinal phenotype of CF. Even though no particular allele or haplotype in ATB(0) appears to be associated to CF-MI disease, new SNPs identified should be useful in segregation and linkage disequilibrium analyses in families affected by other disorders caused by the impairment of neutral amino acid transport.  (+info)

Characterisation and cloning of a Na(+)-dependent broad-specificity neutral amino acid transporter from NBL-1 cells: a novel member of the ASC/B(0) transporter family. (8/71)

Na(+)-dependent neutral amino acid transport into the bovine renal epithelial cell line NBL-1 is catalysed by a broad-specificity transporter originally termed System B(0). This transporter is shown to differ in specificity from the B(0) transporter cloned from JAR cells [J. Biol. Chem. 271 (1996) 18657] in that it interacts much more strongly with phenylalanine. Using probes designed to conserved transmembrane regions of the ASC/B(0) transporter family we have isolated a cDNA encoding the NBL-1 cell System B(0) transporter. When expressed in Xenopus oocytes the clone catalysed Na(+)-dependent alanine uptake which was inhibited by glutamine, leucine and phenylalanine. However, the clone did not catalyse Na(+)-dependent phenylalanine transport, again as in NBL-1 cells. The clone encoded a protein of 539 amino acids; the predicted transmembrane domains were almost identical in sequence to those of the other members of the B(0)/ASC transporter family. Comparison of the sequences of NBL-1 and JAR cell transporters showed some differences near the N-terminus, C-terminus and in the loop between helices 3 and 4. The NBL-1 B(0) transporter is not the same as the renal brush border membrane transporter since it does not transport phenylalanine. Differences in specificity in this protein family arise from relatively small differences in amino acid sequence.  (+info)

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, S by Colas Claire, Christof Grewer et al.Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, S by Colas Claire, Christof Grewer et al.
The Alanine-Serine-Cysteine transporter ASCT2 (SLC1A5) is a membrane protein that transports neutral amino acids into cells in exchange for outward movement of intracellular amino acids. ASCT2 is highly expressed in peripheral tissues such as the lung and intestines where it contributes to the homeostasis of intracellular concentrations of neutral amino acids. ASCT2 also plays an important role in the development of a variety of cancers such as melanoma by transporting amino acid nutrients such as glutamine into the proliferating tumors. Therefore, ASCT2 is a key drug target with potentially great pharmacological importance. Here, we identify seven ASCT2 ligands by computational modeling and experimental testing. In particular, we construct homology models based on crystallographic structures of the aspartate transporter Glt(Ph) in two different conformations. Optimization of the models binding sites for protein-ligand complementarity reveals new putative pockets that can be targeted via structure
https://orb.binghamton.edu/chem_fac/5/
Plus itPlus it
The NMDA receptor co-agonist D-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2 which may regulate its extracellular levels in the CNS. We tested inhibitors of ASCT1 and ASCT2 for their effects in rodent models of schizophrenia and visual dysfunction which had previously been shown to be responsive to D-serine. L-4-fluorophenylglycine (L-4FPG), L-4-hydroxyPG (L-4OHPG) and L-4-chloroPG (L-4ClPG) all showed high plasma bioavailability when administered systemically to rats and mice. L-4FPG showed good brain penetration with brain:plasma ratios of 0.7-1.4, however values for L-4OHPG and L-4ClPG were lower. Systemically administered L-4FPG potently reduced amphetamine-induced hyperlocomotion in mice, whereas L-4OHPG was 100-fold less effective and L-4ClPG inactive at the doses tested. L-4FPG and L-4OHPG did not impair visual acuity in naive rats, and acute systemic administration of L-4FPG significantly improved the deficit in contrast sensitivity in blue-light treated ...
http://jpet.aspetjournals.org/content/early/2018/08/31/jpet.118.251116
Glutamine - AMINO ACIDS - ProductsGlutamine - AMINO ACIDS - Products
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. ...
https://www.iris-biotech.de/products/amino-acids/glutamine.html
Reactive oxygen species modulate Na<sup>+</sup>-coupled neutral amino acid transporter 1 expression in piglet pulmonary...Reactive oxygen species modulate Na<sup>+</sup>-coupled neutral amino acid transporter 1 expression in piglet pulmonary...
TY - JOUR. T1 - Reactive oxygen species modulate Na+-coupled neutral amino acid transporter 1 expression in piglet pulmonary arterial endothelial cells. AU - Dikalova, Anna E.. AU - Aschner, Judy L.. AU - Zhang, Yongmei. AU - Kaplowitz, Mark R.. AU - Fike, Candice D.. N1 - Funding Information: This work was supported by National Heart, Lung, and Blood Institute Grant RO1-HL-097566 (to C. Fike). Publisher Copyright: © 2019 the American Physiological Society.. PY - 2019/4. Y1 - 2019/4. N2 - We have previously shown that Na+-coupled neutral amino acid transporter 1 (SNAT1) modulates nitric oxide (NO) production in pulmonary arterial endothelial cells (PAECs) from newborn piglets. Specifically, the ability to increase NO production in response to the L-arginine-NO precursor L-citrulline is dependent on SNAT1 expression. Elucidating factors that regulate SNAT1 expression in PAECs could provide new insights and therapeutic targets relevant to NO production. Our major goals were to determine if ...
https://einstein.pure.elsevier.com/en/publications/reactive-oxygen-species-modulate-nasupsup-coupled-neutral-amino-a
The importance of serine metabolism in cancer | JCBThe importance of serine metabolism in cancer | JCB
As discussed earlier, cells can acquire serine by either synthesizing it internally or importing serine from the environment. Serine is a small, neutral amino acid and, as such, can be transported by one of three systems. Two of the systems are sodium dependent: the alanine/serine/cysteine/threonine transporters ASCT1 and ASCT2 (encoded by SLC1A4 and SLC1A5, respectively) and the system A transporters SAT1 and SAT2 (encoded by SLC38A1 and SLC38A2, respectively). The third is a family of neutral amino acid antiporters, the alanine/serine/cysteine transporter (ASC) system (El-Hattab, 2016). These antiporters are of particular interest because they are active even at steady state, so that for instance, one molecule of intracellular serine can be exchanged for one molecule of extracellular serine. Normally this process goes unnoticed, but a recent study (DeNicola et al., 2015) points out that it can complicate interpretation of heavy isotope-labeling experiments by setting up an exchange flux ...
http://jcb.rupress.org/content/214/3/249?cct=1418
Amino AcidsAmino Acids
Supply of amino acids to the body provides repair treatment means nourish human skin, nails and hair result in delay aging process naturally. Supply of amino acids strengthens connective tissue to keep our skin smooth, shine, glowing and elastic. Creatine play very important role to keep skin healthy and this creatine is made up of amino acids like Arginine and Methionine. Glutamine amino acid is responsible to regulate acid-base balance as a result it supports healthy skin. Carnitine is a di-peptide containing two essential amino acids lysine and Methionine. Carnitine helps in burning fat to produce energy so also known as fat burner so also added in fitness and wellness program ...
https://chemistrynotesinfo.blogspot.com/2016/11/amino-acids.html
Is glutamine a basic amino acid? - Answered by top doctors on HealthTapIs glutamine a basic amino acid? - Answered by top doctors on HealthTap
Dr. Mandanas responded: Glutamine amino acid. Glutamine is an Amino Acid (basic building block of proteins). People take it for various reasons as a dietary supplement. It purportedly helps maintain |a href=/topics/muscle-mass track_data={
https://www.healthtap.com/user_questions/167197-is-glutamine-a-basic-amino-acid
Palacín, Manuel<...Palacín, Manuel<...
Giacopo, Andrea Di; Rubio-Aliaga, Isabel; Cantone, Alessandra; Artunc, Ferruh; Rexhepaj, Rexhep; Frey-Wagner, Isabelle; Font-Llitjós, Mariona; Gehring, Nicole; Stange, Gerti; Jaenecke, Isabel; Mohebbi, Nilufar; Closs, Ellen I; Palacín, Manuel; Nunes, Virginia; Daniel, Hannelore; Lang, Florian; Capasso, Giovambattista; Wagner, Carsten A (2013). Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice. American Journal of Physiology. Renal, Fluid and Electrolyte Physiology, 305(12):F1645-F1655.. Mariotta, Luca; Ramadan, Tamara; Singer, Dustin; Guetg, Adriano; Herzog, Brigitte; Stoeger, Claudia; Palacín, Manuel; Lahoutte, Tony; Camargo, Simone M R; Verrey, François (2012). T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control. Journal of Physiology, 590(Pt 24):6413-6424.. ...
http://www.zora.uzh.ch/view/authors_for_linking_in_citation/Palac=EDn=3AManuel=3A=3A.html
KGW Kills Interview With Feminist Nail Polish Company, Calling Politics Too Pointed - Willamette WeekKGW Kills Interview With Feminist Nail Polish Company, Calling Politics Too Pointed - Willamette Week
The groups we donate to are all wonderful, legal, organizations who are doing their damndest to help people, Dawn says. From the Immigrant and Refugee Community Organization helping immigrants to become self-sufficient in their new communities to the NAACP trying to make sure every person in this country is able to vote and participate in democracy. Its strange to me those ideas, while nestled in the fun vibe of getting a manicure, are somehow too scandalous for TV. But Trump can call Africa a shithole, and theres 50,000 episodes of Law & Order-esque shows that deal with the most detailed horrors of the world seemingly aired at any moment, and both those things are fine to air?. ...
https://www.wweek.com/culture/2018/03/05/kgw-kills-interview-with-feminist-nail-polish-company-calling-politics-too-pointed/
TCDB » Human MTPsTCDB » Human MTPs
Rasko JE, Battini JL, Gottschalk RJ, Mazo I, Miller AD. The RD114/simian type D retrovirus receptor is a neutral amino acidtransporter.Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2129-34. PMID: 10051606 [PubMed - indexed for MEDLINE]. The RD114/simian type D retroviruses, which include the feline endogenous retrovirus RD114, all strains of simian immunosuppressive type D retroviruses, the avian reticuloendotheliosis group including spleen necrosis virus, and baboon endogenous virus, use a common cell-surface receptor for cell entry. We have used a retroviral cDNA library approach, involving transfer and expression of cDNAs from highly infectable HeLa cells to nonpermissive NIH 3T3 mouse cells, to clone and identify this receptor. The cloned cDNA, denoted RDR, is an allele of the previously cloned neutral amino acid transporter ATB0 (SLC1A5). Both RDR and ATB0 serve as retrovirus receptors and both show specific transport of neutral amino acids. We have localized the receptor by radiation hybrid ...
http://tcdb.org/hgnc_explore.php?symbol=SLC1A5
JCI - Targeting lactate metabolism for cancer therapeuticsJCI - Targeting lactate metabolism for cancer therapeutics
Oncoproteins drive the expression of genes involved in glycolysis and glutaminolysis, which results in production of excess amounts of lactate. Aberrant PI3K/AKT signaling and the transcriptional oncoproteins HIF-1α and MYC regulate the transcription of GLUT, HK2, TPI, ENO, and LDHA. HIF-1α induces the transcription of PFKFB3, which favors the production of F2,6BP, an allosteric activator of PFK1. The tumor suppressor protein p53 induces the expression of TIGAR, which dephosphorylates F2,6BP, blocking activation of PFK1 and inhibiting glycolysis. HIF-1α and MYC regulate the expression and splicing of the PKM2 isoform. MYC also regulates the expression of the glutamine transporter ASCT2 and GLS. Monocarboxylic acid transporters (MCTs) export lactate and protons and are regulated by HIF-1α and MYC. AcCoA, acetyl-CoA; ASP, aspartate; ASCT2, glutamine transporter; G, glucose; G6P, glucose-6-phosphate, F6P, fructose-6-phosphate; DHAP, dihydroxyacetone phosphate; GA3P, glyceraldehyde-3-phosphate; ...
https://rihonet.net.mobile.jci.org/articles/view/69741/figure/1
Human Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Protein (GST tag), Recombinant | ABIN1320502Human Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Protein (GST tag), Recombinant | ABIN1320502
Recombinant Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Protein (GST tag). Spezies: Human. Quelle: Wheat germ. Jetzt Produkt ABIN1320502 bestellen.
http://www.antikoerper-online.de/protein/1320502/Solute+Carrier+Family+6+Neutral+Amino+Acid+Transporter,+Member+19+SLC6A19+AA+326-414,+partial+protein+GST+tag/
Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific...Phylogenetic analysis of the vertebrate excitatory/neutral amino acid transporter (SLC1/EAAT) family reveals lineage specific...
RESULTS: In a genomic survey where we manually annotated and analyzing sequences from more than 300 SLC1 genes (from more than 40 vertebrate species), we found evidence for an interesting evolutionary history of this gene family. While human and mouse genomes contain 7 SLC1 genes, in prototheria, sauropsida, and amphibia genomes up to 9 and in actinopterygii up to 13 SLC1 genes are present. While some of the additional slc1 genes in ray-finned fishes originated from R3, the increased number of SLC1 genes in prototheria, sauropsida, and amphibia genomes originates from specific genes retained in these lineages.Phylogenetic comparison and microsynteny analyses of the SLC1 genes indicate, that theria genomes evidently lost several SLC1 genes still present in the other lineage. The genes lost in theria group into two new subfamilies of the slc1 gene family which we named slc1a8/eaat6 and slc1a9/eaat7 ...
https://www.zora.uzh.ch/id/eprint/41720/
TCDB » SEARCHTCDB » SEARCH
Plasma membrane System A-like neutral amino acid transporter, SA1, SAT2 or SNAT2 (transports small, neutral aliphatic amino acids including α-(methylamino)isobutyrate, mAIB with Na+ (1:1 stoichiometry; Km = 200-500 μM)). Asparagine 82 controls the interaction of Na+ with the transporter (Zhang and Grewer, 2007). The C-terminal domain regulates transport activity through a voltage-dependent process (Zhang et al., 2011). An 11 TMS topology has been experimentally demonstrated (Ge et al. 2018 ...
http://tcdb.org/search/result.php?tc=2.A.18.6.4
Atb - Now Or Never lyrics | LyricsMode.comAtb - Now Or Never lyrics | LyricsMode.com
Now Or Never lyrics by Atb: Im wide awake and I couldnt care less / What people say and my hearts no longer under arrest / Smashed
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P20 Sterile Tips, ATB, Clear, 0.5-20µL | PerkinElmer
900ul filter tip conductive qt. We offer sterile and non-sterile tips for a variety of dispenser channel sizes and volume requirements.
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P20 Sterile Tips, ATB, Clear, 0.5-20µL | PerkinElmerP20 Sterile Tips, ATB, Clear, 0.5-20µL | PerkinElmer
900ul filter tip conductive qt. We offer sterile and non-sterile tips for a variety of dispenser channel sizes and volume requirements.
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CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth | CrickCD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth | Crick
Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations. However, the cellular hierarchy underlying PDAC cell diversity is unknown. Here we identify the tetraspanin CD9 as a marker of PDAC tumour-initiating cells. CD9high cells had increased organoid formation capability, and generated tumour grafts in vivo at limiting dilutions. Tumours initiated from CD9high cells recapitulated the cellular heterogeneity of primary PDAC, whereas CD9low cells produced only duct-like epithelial progeny. CD9 knockdown decreased the growth of PDAC organoids, and heterozygous CD9 deletion in Pdx1-Cre; LSL-KRasG12D; p53F/F mice prolonged overall survival. Mechanistically, CD9 promoted the plasma membrane localization of the glutamine transporter ASCT2, enhancing glutamine uptake in PDAC cells. Thus, our study identifies a PDAC subpopulation capable of initiating PDAC and giving rise to PDAC heterogeneity, suggesting that the ...
https://www.crick.ac.uk/research/publications/cd9-identifies-pancreatic-cancer-stem-cells-and-modulates-glutamine-metabolism-to-fuel-tumour-growth
ABCB14 - ABC transporter B family member 14 - Arabidopsis thaliana (Mouse-ear cress) - ABCB14 gene & proteinABCB14 - ABC transporter B family member 14 - Arabidopsis thaliana (Mouse-ear cress) - ABCB14 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
http://www.uniprot.org/uniprot/Q9C7F2
LISINOPRIL ATB 20mg - Pret PretLISINOPRIL ATB 20mg - Pret Pret
LISINOPRIL ATB 20mg - Pret - Pret compensat si necompensat al medicamentului, pret in farmacii, preturile tuturor echivalentelor, preturile valabile azi
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Identification and Functional Characterization of a Na+-Independent Large Neutral Amino Acid Transporter, LAT1, in Human and...Identification and Functional Characterization of a Na+-Independent Large Neutral Amino Acid Transporter, LAT1, in Human and...
Reverse transcription-PCR was performed based on the method of Sugawara et al., 59 with slight modifications, using 1 μg of total RNA isolated from human cornea (kindly provided by Alcon Laboratories, Fort Worth, TX). The forward and reverse primers were 5′-TCT CAC TGC TTA ACG GCG TGT G-3′, and 5′-TCC CTG GCC AAG TCT AAC AAT G-3′, respectively. These primers correspond to the nucleotide positions 110-132 and 606-628 in hLAT1 cDNA, respectively. RT-PCR was performed with a commercial kit (GeneAmp; Applied Biosystems, Foster City, CA). The conditions for reverse transcription were as follows: denaturation of the template RNA for 10 minutes at 70°C and reverse transcription for 60 minutes at 42°C. The conditions for PCR amplification were as follows: denaturation for 1 minute at 94°C; annealing for 1 minute at 58°C, and extension for 1 minute at 72°C, 37 cycles; final extension for 10 minutes at 72°C. The resultant product (∼520 bp) was subcloned in pGEM-T vector and sequenced from ...
http://iovs.arvojournals.org/article.aspx?articleid=2181705
American Society for Cytotechnology (ASCT), ASCT Career Center|Find Your Career HereAmerican Society for Cytotechnology (ASCT), ASCT Career Center|Find Your Career Here
American Society for Cytotechnology (ASCT) - Find your next career at ASCT Career Center. Check back frequently as new jobs are posted every day.
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ATB Presents: Muro, Spleen, Ego, Cage Kicker | StressfaktorATB Presents: Muro, Spleen, Ego, Cage Kicker | Stressfaktor
ATP 2020 Reopening. We are reopening for another year and this time were bringing you a sick local and international PUNK line up for the fist pumpers out there!. There will be food and delicious new shots and cocktails.. ...
https://stressfaktor.squat.net/node/205826
ATB: Im really excited about the people; we will have an unforgettable evening - Clubbing-Croatia.comATB: Im really excited about the people; we will have an unforgettable evening - Clubbing-Croatia.com
Hello Mr. Tanneberger, it is a joy and a privilege to have this opportunity to pick your brain for a while on all things electronic.
https://clubbing-croatia.com/whats-hot/interview/atb-im-really-excited-about-the-people-we-will-have-an-unforgettable-evening-27022020
ASC2抗体|Abcam中国|Anti-ASC2抗体ASC2抗体|Abcam中国|Anti-ASC2抗体
ASC2兔多克隆抗体(ab47092)可与小鼠, 大鼠, 人, 沙鼠样本反应并经WB, IP, IHC实验严格验证。所有产品均提供质保服务，中国75%以上现货。
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Adelaide Research & Scholarship: The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine...Adelaide Research & Scholarship: The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine...
OBJECTIVES: To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1. STUDY DESIGN: Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies targeting syncytin-1. Syncytin-1 immunosuppression was tested, using either a syncytin-1 recombinant ectodomain protein or a synthetic peptide with the human syncytin-1 immunosuppressive domain sequence, in an in vitro human blood culture system immune challenged with LPS or PHA. The inhibition of cytokine production by syncytin-1 was determined by ELISA of TNF-α, IFN-γ and CXCL10. BeWo cells were stimulated with CRH or vehicle for 24 h. mRNA and Protein was extracted from the cells for real-time PCR and ...
https://digital.library.adelaide.edu.au/dspace/handle/2440/74740
The role of the neutral amino acid transporter SNAT2 in cell volume regulation.
Sodium-dependent neutral amino acid transporter-2 (SNAT2), the ubiquitous member of SLC38 family, accounts for the activity of transport system A for neutral amino acids in most mammalian tissues. As the transport process performed by SNAT2 is highly
http://www.biomedsearch.com/nih/role-neutral-amino-acid-transporter/16734764.html
ASC 360 TENNIS SYSTEM® | ASC Sánchez-Casal Tennis AcademyASC 360 TENNIS SYSTEM® | ASC Sánchez-Casal Tennis Academy
We are proud of one of the recent accolades achieved by the Academy founders: in 2017, Emilio Sanchez and Sergio Casal received the Philippe Chatrier Award: which is the ITFs highest accolade, awarded to individuals for their outstanding contributions to tennis. As ITF President David Haggerty said: We are delighted to present Sergio Casal and Emilio Sanchez with the Philippe Chatrier Award for their contributions to tennis as a successful doubles team and in the field of coaching. Their on-court achievements paved the way for further Spanish success, and in founding a successful coaching academy, they have shaped the careers of several prominent players and the lives of many more.. We invite you to get to know our Academy and our system by joining any of our Weekly Programs in Naples (FL, USA), Barcelona (Spain), Atlanta (GA, USA) or Nanjing (China).. ...
https://www.sanchez-casal.com/blog/asc-360-tennis-system/
Maximum L-Glutamine 1000 Mg - Alfa Vitamins StoreMaximum L-Glutamine 1000 Mg - Alfa Vitamins Store
Maximum L-Glutamine / 1000 mg / 100 capsules - L-glutamine is considered the most abounding amino acid in blood plasma as well as a main transporter of nitrogen.Maximum L-Glutamine / 1000 mg / 100 capsules - What is Maximum L-GLUTAMINE?L-Glutamine is one
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Aminostar L-Glutamine Micro meshed 240kps | Výživa pro fitnessAminostar L-Glutamine Micro meshed 240kps | Výživa pro fitness
L-Glutamine L-Glutamine Micro meshed je volná aminokyselina, která má největší zastoupení ve svalové buňce cca 70%. Při nedostatečném množství L-Glutaminu ve svalových vláknech není možný další svalový růst. Čistý L-Glutamine Micro…
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BioTechUSA 100% L-Glutamine (240g)
BioTechUSA 100% L-Glutamine is 100% ready as well to be taken right before and after your workout, providing 5000 mg L-Glutamine each time.
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ATB Tariff Reduction financial definition of ATB Tariff ReductionATB Tariff Reduction financial definition of ATB Tariff Reduction
Definition of ATB Tariff Reduction in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is ATB Tariff Reduction? Meaning of ATB Tariff Reduction as a finance term. What does ATB Tariff Reduction mean in finance?
https://financial-dictionary.thefreedictionary.com/ATB+Tariff+Reduction
X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications • Research -...X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications • Research -...
The retroviral envelope-derived proteins syncytin-1 and syncytin-2 (syn1 and syn2) drive placentation in humans by forming a syncytiotophoblast, a structure
https://research.pasteur.fr/en/publication/x-ray-structures-of-the-post-fusion-6-helix-bundle-of-the-human-syncytins-and-their-functional-implications/
100% L-GLUTAMINE100% L-GLUTAMINE
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L-Glutamine 850 mg 250 Caps , made by pure-encapsulationL-Glutamine 850 mg 250 Caps , made by pure-encapsulation
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Diamond Publications - Publication
Abstract: The L-type neutral amino acid transporter 1 (LAT1/SLC7A5) is one of 7 light chains that can form a heteromeric amino acid transporter (HAT) with the type II single pass glycoprotein CD98hc (SLC3A2). LAT1-CD98hc transports essential amino acids and some of their catabolites, such as tryptophan, methionine and kynurenine, across the plasma membranes of normal and cancer cells. It is also a drug transporter, carrying drugs such as gabapentin and L-DOPA across the blood brain barrier. The atypical heterodimeric nature of LAT1-CD98hc and its role in disease and drug delivery, motivate the structural characterisation of the HAT. Sequence analysis revealed two putative cholesterol binding motifs conserved between dDAT and LAT1 as well as 32 putative CRAC/CARC motifs. The crystal structures of various bacterial homologues of LAT1 were used for structure prediction, in order to visualise these putative cholesterol binding motifs and assess their plausibility. Here is presented the first binding ...
https://publications.diamond.ac.uk/pubman/viewpublication?publicationId=11358
SLCtables
Disease: (OMIM: 138500 242600 608331) Defects in SLC36A2 are a cause of hyperglycinuria (HG) [MIM:138500]. It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones; Defects in SLC36A2 are a cause of iminoglycinuria (IG) [MIM:242600]. It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Note=Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families ...
http://slc.bioparadigms.org/protein?GeneName=SLC36A2
10 arguments for using Stöber servo systems - ATB Automation10 arguments for using Stöber servo systems - ATB Automation
Blog of Marcel Goes, sales engineer at ATB Automation, with unique features of the Stöber servo systems. Machine builders see the benefits.
https://atbautomation.eu/en/blog/40-10-arguments-why-oems-worldwide-choose-stober-servo-systems.html
Educational Webinars
Download the 2020 Educational Webinar Registration Form and mail or email to ASCT with payment. You will receive your webinar access information via email from ASCT after payment is received. Using your email address, the ASCT will send you the link to access the webinar. Participants can choose to hear the audio via the phone or over their computer speakers. Each webinar will offer one CE credit as defined by the ASCP CMP.. All Members and Non-Members may purchase ASCT educational webinars online by clicking here.. Individual Webinar Registration ...
http://www.asct.com/ASCTWeb/Education_Plus/Educational_Webinars/ASCTWeb/Content/Educational_Webinars.aspx?hkey=8e1fa75a-ec4e-4ba5-9791-fa74ed4e0931
Ethambutol Atb® 400 mg | AntibioticeEthambutol Atb® 400 mg | Antibiotice
Dear partner,. Protecting your personal data rights is an important aspect for Antibiotice S.A. For this reason we inform you that your data will be processed to meet the legal obligations to allow access to certain information only to health professionals. In the absence of the data required by this form, access will be restricted to you.. Your personal data are not transferred to partners or institutions and their deletion will only take place as a result of your request.. We also inform you that you have the following rights with respect to the personal data you provide us:. ...
https://www.antibiotice.ro/en/medicamente/ethambutol-atb-400-mg/?first-letter=F
Business sentiment still suffering | ATB FinancialBusiness sentiment still suffering | ATB Financial
The Business Outlook Survey indicator recovered somewhat but remains well below its historical average, signalling weak business sentiment
https://www.atb.com/company/insights/the-owl/different-survey-same-results/
Dropper bottles - System BDropper bottles - System B
Gerresheimer has a very broad standard product range for ophthalmic applications for the pharmaceutical market and we can easily cover our customers needs. Using our ideas and extensive experience to produce high-quality and user-friendly packaging solut
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L-Glutamine Supplements - Benefits and Side Effects | HubPagesL-Glutamine Supplements - Benefits and Side Effects | HubPages
L-glutamine is an amino acid. It is one of the building blocks of protein and in the grand scheme of the body one of the building blocks of life.
https://hubpages.com/health/L-Glutamine-Supplements-Benefits-and-Side-Effects
L-Glutamine For Leaky Gut Syndrome - Not To Be Taken LightlyL-Glutamine For Leaky Gut Syndrome - Not To Be Taken Lightly
While L-Glutamine continues to become more popular for its use with digestive issues, particularly the growing complaint of leaky gut, it has some risks
http://healthvibed.com/l-glutamine-for-leaky-gut-syndrome/
L-GLUTAMINE SUPREMIUM LAB - VaxtarvörurL-GLUTAMINE SUPREMIUM LAB - Vaxtarvörur
SUPREMIUM LAB L-GLUTAMINE inniheldur Hreint L-Glutamín + B-6 vítamín. Ráðlagður skammtur er 5g í vatn eða drykk eftir fyrir æfingu. 50 skammtar Hreint L-Glutamín + B-6 vítamín. ...
https://vaxtarvorur.is/vara/l-glutamine-supremium-lab/
Jaringan Pariwisata Dunia pengin Travel lan Pariwisata ditahanJaringan Pariwisata Dunia pengin Travel lan Pariwisata ditahan
Jaringan Pariwisata Dunia sing selaras karo Dewan Pariwisata Afrika (ATB) njaluk masarakat supaya matesi perjalanan menyang bisnis penting. Pariwisata Dunia - Breaking International News - eTurboNews | Karsane | Warta Perjalanan
https://jw.eturbonews.com/2216494/jaringan-pariwisata-dunya-pengin-lelungan-lan-pariwisata-tetep-ditahan/
CystourethroscopyCystourethroscopy
I need some help. I have a ASC case where the MD did a cystourethroscopy w/ bilaterial retrograde ureterograms. He also did Litholapaxy with the extra
https://www.aapc.com/memberarea/forums/8835-cystourethroscopy.html
Lysine exporter - WikipediaLysine exporter - Wikipedia
Lysine Exporters are a superfamily of transmembrane proteins which export amino acids, lipids and heavy metal ions. They provide ionic homeostasis, play a role in cell envelope assembly, and protect from excessive concentrations of heavy metals in cytoplasm. The superfamily was named based on the early discovery of the LysE carrier protein of Corynebacterium glutamicum. 2.A.75 - The L-Lysine Exporter (LysE) Family 2.A.76 - The Resistance to Homoserine/Threonine (RhtB) Family 2.A.77 - The Cadmium Resistance (CadD) Family 2.A.95 - The 6TMS Neutral Amino Acid Transporter (NAAT) Family 2.A.106 - The Ca2+:H+ Antiporter-2 (CaCA2) Family 2.A.107 - The Mn2+ exporter (MntP) Family 2.A.108 - The Iron/Lead Transporter (ILT) Family 2.A.109 - The Tellurium Ion Resistance (TerC) Family 2.A.113 - The Nickel/Cobalt Transporter (NicO) Family 2.A.116 - The Peptidoglycolipid Addressing Protein (GAP) Family 5.A.1 - The Disulfide Bond Oxidoreductase D (DsbD) Family Two members of the LysE family (LysE of ...
https://en.wikipedia.org/wiki/Lysine_exporter
Determination of molecular weight of neutral amino acids with chloramine-T - ePrints@UOMDetermination of molecular weight of neutral amino acids with chloramine-T - [email protected]
Rai, K. M. Lokanatha and Umesha, K. B. and Yathirajan, H. S. (1999) Determination of molecular weight of neutral amino acids with chloramine-T. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 76 (3). pp. 170-171. Full text not available from this repository. (Request a copy ...
http://eprints.uni-mysore.ac.in/4959/
L-GlutamineL-Glutamine
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Transport System Bögl - Max BöglTransport System Bögl - Max Bögl
Climate protection and traffic turn are among the challenges of this century. Constant urbanization requires a mobility solution that is quiet, space-...
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Why You Should Move to Richardson, TX - ATB Moving
Richardson is located north of downtown Dallas. Its rich history, ideal location, and lucrative economy make it a perfect place to call home.
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l-Glutamine - Thriving 4 Healthl-Glutamine - Thriving 4 Health
30 capsules Benefits: Helps supply the brain with energy. Supports cellular growth, energy and repair. Also supports the immune system and digestion. Provides 500 mg l-glutamine per capsule. How It Works: L-glutamine is an amino acid (a protein building block) that is important in supplying the brain with energy. Its m
https://thriving4health.com/products/l-glutamine
L-Glutamine Benefits
Learn more about how L-glutamine is the most abundant amino acid in the body and how science has shown L-glutamine benefits everyone.
http://www.sati.com/en-us/edu/l-glutamine-benefits
Met-RX - L-Glutamine - 400g - Anti-Catabolic & Recovery AgentMet-RX - L-Glutamine - 400g - Anti-Catabolic & Recovery Agent
L-Glutamine - 400g by Met-Rx is an Anti-Catabolic & Recovery Agent. Supports protein metabolism. Supports recovery from workouts.
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PPT - Praktické cviÄ enie Ä . 2 Stafylokokové infekcie PowerPoint Presentation - ID:5231560PPT - Praktické cviÄ enie Ä . 2 Stafylokokové infekcie PowerPoint Presentation - ID:5231560
Praktické cvičenie č. 2 Stafylokokové infekcie. Diagnostika stafylokokových infekcií Diagnostický model: absces - hnis, enterotoxikóza - zvyšky potravín, osteomyelitída - punktát, Mikroskopia, kultivácia, biochemické testy, dôkaz patogenity, citlivosť na ATB. 1 normálna...
https://www.slideserve.com/darius/praktick-cvi-enie-2-stafylokokov-infekcie
Designed for comfort and built to last. - PDFDesigned for comfort and built to last. - PDF
Designed for comfort and built to last. Inter IKEA Systems B.V Whether we work in an office or at home, many of us spend the majority of the day at a desk. A comfortable workspace is therefore essential
http://docplayer.net/20748253-Designed-for-comfort-and-built-to-last.html
List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.157)
... amino acid transport system a MeSH D12.776.157.530.200.500.200 - amino acid transport system asc MeSH D12.776.157.530.200.500. ... amino acid transport systems, acidic MeSH D12.776.157.530.200.249.500 - amino acid transport system x-ag MeSH D12.776.157.530. ... amino acid transport systems, basic MeSH D12.776.157.530.200.374.600 - amino acid transport system y+ MeSH D12.776.157.530. ... cationic amino acid transporter 2 MeSH D12.776.157.530.200.374.750 - amino acid transport system y+l MeSH D12.776.157.530. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
List of MeSH codes (D12.776.543)List of MeSH codes (D12.776.543)
... amino acid transport system a MeSH D12.776.543.585.200.500.200 - amino acid transport system asc MeSH D12.776.543.585.200.500. ... amino acid transport systems, acidic MeSH D12.776.543.585.200.249.500 - amino acid transport system x-ag MeSH D12.776.543.585. ... amino acid transport systems, basic MeSH D12.776.543.585.200.374.600 - amino acid transport system y+ MeSH D12.776.543.585. ... cationic amino acid transporter 2 MeSH D12.776.543.585.200.374.750 - amino acid transport system y+l MeSH D12.776.543.585. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
Transporter Classification DatabaseTransporter Classification Database
Family 3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family 3.C.1 The Na+ Transporting ... L-Asc) Family 4.B.1 The Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) Family 4.C.1 The Proposed Fatty Acid ... Family 2.A.78 The Branched Chain Amino Acid Exporter (LIV-E) Family 2.A.79 The Threonine/Serine Exporter (ThrE) Family 2.A.80 ... approved classification system for membrane transport proteins, including ion channels. The upper level of classification and a ...
https://en.wikipedia.org/wiki/Transporter_Classification_Database
Aquaculture of salmonidsAquaculture of salmonids
... and amino acids as feed. Some of the eicosapentaenoic acid and docosahexaenoic acid (in Omega-3 fatty acids) may be replaced by ... Aquaculture Stewardship Council, (ASC) (2017). ASC Salmon Standard (V1.1) (PDF). ASC. "Salmon Aquaculture Dialogue: Benthic ... More advanced systems use a percussive-stun harvest system that kills the fish instantly and humanely with a blow to the head ... Modern harvesting methods are shifting towards using wet-well ships to transport live salmon to the processing plant. This ...
https://en.wikipedia.org/wiki/Aquaculture_of_salmonids
Immune systemImmune system
... mainly on the observation that hydrophilic amino acids are overrepresented in epitope regions than hydrophobic amino acids; ... During pregnancy, a particular type of antibody, called IgG, is transported from mother to baby directly through the placenta, ... the adaptor protein ASC, and the effector molecule pro-caspase-1) that form in response to cytosolic PAMPs and DAMPs, whose ... The immune system interacts intimately with other systems, such as the endocrine and the nervous systems. The immune system ...
https://en.wikipedia.org/wiki/Immune_system
List of file formatsList of file formats
Sometimes also given as FNA or FAA (Fasta Nucleic Acid or Fasta Amino Acid). FASTQ - The FASTQ format, for sequence data with ... bib - BibTeX enl - EndNote ris - Research Information Systems RIS (file format) .fits - FITS (Flexible Image Transport System) ... WOFF - Web Open Font Format ASC - ASCII point of interest (POI) text file APR - ESRI ArcView 3.3 and earlier project file DEM ... file system. Examples of operating systems that do not impose this limit include Unix-like systems, and Microsoft Windows NT, ...
https://en.wikipedia.org/wiki/List_of_file_formats
OSIRIS-RExOSIRIS-REx
Organic molecules, such as amino acids, have previously been found in meteorite and comet samples, indicating that some ... Propulsion system: Based on a hydrazine monopropellant system developed for the Mars Reconnaissance Orbiter, carrying 1,230 kg ... "Canada's role in OSIRIS-REx". asc-csa.gc.ca. 4 March 2013. Retrieved 2 October 2019. Lauretta, Dante (27 November 2013). "How ... and the capsule will land with a parachute at the Utah Test and Training Range in September 2023 before being transported to ...
https://en.wikipedia.org/wiki/OSIRIS-REx
List of acronyms: AList of acronyms: A
... amino acid decarboxylase (i) aromatic L-amino acid decarboxylase (i) Australian Antarctic Data Centre AAFC (i) U.S. Army Air ... Automatic Landing System ALSHS - (a) Abraham Low Self-Help Systems ALSP - (i) Aggregate Level Simulation Protocol ALTE - (a) ... ATI Technologies) Air Transport International - American cargo airline Atisbo - a Local Government Area in Nigeria named for ... American Standard Code for Information Interchange ASC+T - (i) Anti Slip Control + Traction ASD (i) (U.S.) Assistant Secretary ...
https://en.wikipedia.org/wiki/List_of_acronyms:_A
DNA vaccineDNA vaccine
Cytotoxic T-cells recognise small peptides (8-10 amino acids) complexed to MHC class I molecules. These peptides are derived ... The innate system works with the adaptive immune system to mount a response against the DNA encoded protein. CpG-S sequences ... Antibody-secreting cells (ASC) migrate to the bone marrow and spleen for long-term antibody production, and generally localise ... Anderson RG, Kamen BA, Rothberg KG, Lacey SW (January 1992). "Potocytosis: sequestration and transport of small molecules by ...
https://en.wikipedia.org/wiki/DNA_vaccine
Water on MarsWater on Mars
Benison, K; Bowen, B (2006). "Acid saline lake systems give clues about past environments and the search for life on Mars". ... Bada, J.; Glavin, D. P.; McDonald, G. D.; Becker, L. (1998). "A Search for Endogenous Amino Acids in Martian Meteorite AL84001 ... "CSA - News Release". Asc-csa.gc.ca. July 2, 2009. Archived from the original on July 5, 2011. "Mars Exploration Rover Mission: ... Their shape and orientation suggests long-distance transport from above the rim of the crater, where a channel named Peace ...
https://en.wikipedia.org/wiki/Water_on_Mars
Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo |...Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo |...
A and ASC transport systems and indicates that L121 cells actively transport PTT.119 primarily by the BCH-sensitive, AIB- ... Multiple transport pathways for L1210 cells: uptake of PTT.119, a bifunctional alkylator with carrier amino acids.. *M. Yagi, K ... This is the first report showing that a dipeptide transport system, which is similar but not identical to the well- ... was examined using competition transport assays assessing the ability of the tripeptide to compete with various amino acids and ...
https://www.semanticscholar.org/paper/Antitumor-efficacy-and-acute-toxicity-of-the-novel-Gullbo-Lindhagen/9e575a732827acba4e3c958dac6914bca64bca2d
Pharmaceutical Science - Research output - Research Nebraska
Amino Acid Transport System ASC 42% 9 Scopus citations * Structure-activity studies of aldose reductase inhibitors containing ... Phospholipid effects on the rat lens transport systems. Kador, P. F. & Kinoshita, J. H., Jun 1978, In: Experimental Eye ... Transport and phosphorylation of choline in rat lens. Jernigan, H. M., Kador, P. F. & Kinoshita, J. H., 1980, In: Investigative ... Binding of benzo[A]pyrene at 1, 3 and 6 positions to nucleic acids in vitro and in vivo. Rogan, E., Roth, R. & Cavalieri, E., ...
https://experts.nebraska.edu/en/organisations/pharmaceutical-science/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=publicationYearThenTitle&descending=true&page=32
DeCSDeCS
Amino Acid Transport System ASC Entry term(s). Amino Acid Transport System ASC Proteins Amino Acid Transporter ASC System ASC ... Amino Acid Transport System ASC Proteins. Amino Acid Transporter ASC. System ASC Transporter. System ASC Transporter Proteins. ... Amino Acid Transport System ASC - Preferred Concept UI. M0379390. Scope note. A ubiquitous sodium-dependent neutral amino acid ... Amino Acid Transport System ASC [D12.776.157.530.200.500.200] Amino Acid Transport System ASC ...
https://decs.bvsalud.org/en/ths/resource/?id=36163
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
... dependent alanine uptake by blLPM vesicles or the activity of amino acid transport systems, A and ASC. Because ethanol is known ... acids, 2-amino-3-phosphono-propionic acid (APPA) and 2-amino-4-phosphono-butanoic acid (APBA), diminished the amplitude of ... These amino acids might attenuate several causes of fatigue, since they are important energy substrates, transport ammonia ... To examine more closely papillary amino acid transport, we measured transepithelial fluxes of L-[(14)C]alanine and [(14)C] ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=mh:Alanina/antagonistas+%26+inibidores
Staff Profile - Faculty of Medical Sciences - Newcastle UniversityStaff Profile - Faculty of Medical Sciences - Newcastle University
System ASC activity and expression of the amino acid transporter ASCT1 in human intestinal Caco-2 cells. In: JOURNAL OF ... D-Cycloserine transport in human intestinal epithelial (Caco-2) cells is mediated by a H+-coupled amino acid transporter. ... Regulation of the amino acid transporter hEAAC1 in human intestinal Caco-2 cells. In: FASEB JOURNAL. 2000. ... Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. ...
https://www.ncl.ac.uk/medical-sciences/people/profile/barryhirst.html
18F]Fluciclovine PET discrimination between high- and low-grade gliomas | EJNMMI Research | Full Text18F]Fluciclovine PET discrimination between high- and low-grade gliomas | EJNMMI Research | Full Text
... which are predominantly transported via system L amino acid transporters, fluciclovine undergoes cellular transport by both ... system L and system alanine-serine-cysteine (ASC), specifically ASCT2, in human astrocytes and glioma cells [11]. Both system L ... The non-natural amino acid PET radiotracer, anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (FACBC, fluciclovine (18F)) ... Comparative evaluation of transport mechanisms of trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid and L-[methyl-(11)C] ...
https://ejnmmires.springeropen.com/articles/10.1186/s13550-018-0415-3
Similarities of Characterized Proteins
PTIBC_ECOLI / P24241 PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component; EIIBC-Asc; EII-Asc; EC 2.7.1.- ... 618 amino acids: PaperBLAST, CDD 35% identical to query, 97% coverage. b2715 β-glucoside specific PTS enzyme IIBC component (EC ... a V317A or V317M mutation allows it to transport cellobiose as well] from Corynebacterium glutamicum (Brevibacterium flavum). ... 625 amino acids: PaperBLAST, CDD 39% identical to query, 96% coverage. TC 4.A.1.2.5 / Q8GGK3 β-glucoside (methyl-β-glucoside, ...
https://papers.genomics.lbl.gov/cgi-bin/curatedSim.cgi?set=carbon&path=cellobiose&ids=TCDB::ART98499&ids=SwissProt::P24241,TCDB::P24241,ecocyc::ASCF-MONOMER,metacyc::ASCF-MONOMER&ids=TCDB::P08722,ecocyc::BGLF-MONOMER,metacyc::BGLF-MONOMER&ids=TCDB::Q8GGK3
SLC7 family | Transporters | IUPHAR/BPS Guide to PHARMACOLOGYSLC7 family | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY
... transport of most of the neutral amino acids and cationic amino acids (L-arginine, L-lysine and L-ornithine).. Asc-1 appears to ... ATRC1 , ERR , System y+ basic amino acid transporter , REC1L , cationic amino acid transporter, y+ system , cationinc amino ... amino acid transporter light chain, y� system), member 7 , solute carrier family 7 (cationic amino acid transporter, y+ system ... amino acid transporter light chain, y� system), member 6 , solute carrier family 7 (cationic amino acid transporter, y+ system ...
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=169&objId=902#902
Chloride Channels
acid solution transportation systems were present to become energetic during oocyte maturation or growth. L, b0,+, and ASC/asc ... Furthermore to regular - and -amino acids, we utilized cysteic acidity as well as the amino acidity analogues 2-(methylamino) ... Likewise, transport of arginine, a b0,+ substrate [29], was lysine and leucine inhibitable entirely. * Post author By ... Therefore, weve undertaken experiments made to determine whether main amino acidity transportation systems (Desk 1) are ...
http://www.baxkyardgardener.com/category/chloride-channels/
Involvement of Free Radicals in the Development and Progression of Alzheimers Disease | IntechOpenInvolvement of Free Radicals in the Development and Progression of Alzheimer's Disease | IntechOpen
... and nucleic acids, thereby contributing to neurodegeneration. In addition, βA1-42 is recognized by microglial receptors; it ... Amyloid beta-peptide of 42 amino acid residues (Aβ1-42) is the main source of FRs in patients with AD. βA1-42 results from ... the three most common of which are the 695-amino acid form, which is expressed predominantly in the central nervous system (CNS ... The levels and transport of these metals are strictly regulated by the blood-brain barrier (BBB), and disruption of metal ...
https://www.intechopen.com/chapters/52065
TCDB » SuperfamiliesTCDB » Superfamilies
The APC superfamily consists of numerous families of porters that transport amino acids and their dereivatives. See: Chang A.B ... Animal systems are in TC# 3.A.19 while Fungal systems are in TC# 3.A.21. 3-D structural analyses suggest that the EMC family ( ... 4.A.7 - The PTS L-Ascorbate (L-Asc) Family. PTS-GFL Superfamily. Chang A.B., Lin R., Studley W.K., Tran C.V., Saier M.H. Jr. ... 2.A.95 - The 6 TMS Neutral Amino Acid Transporter (NAAT) Family. 2.A.106 - The Ca2+:H+ Antiporter-2 (CaCA2) Family. 2.A.107 - ...
https://tcdb.org/superfamily.php
Science Clips - Volume 10, Issue 21, June 12, 2018Science Clips - Volume 10, Issue 21, June 12, 2018
Methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in various soapberry ( ... Systems thinking and simulation modeling (systems science) provide a set of approaches and techniques to aid decision makers in ... She was taken to the local emergency department and then transported to a larger hospital in Anchorage where she was admitted ... We examined how the absence of caspase-1 and caspase-11, the adapter protein Asc, and other inflammasome components affects ...
https://www.cdc.gov/library/sciclips/issues/v10issue21.html
Kidney-based in vitro models for drug-induced toxicity testing | SpringerLinkKidney-based in vitro models for drug-induced toxicity testing | SpringerLink
Some solutes, such as glucose and amino acids (in purple), are reabsorbed completely by the proximal tubule epithelial cells ... 2) are transported into tubular cells predominantly via the basolateral organic cation transporter 2 (OCT2; SLC22A2) and then ... De Kanter R, Olinga P, De Jager MH, Merema MT, Meijer DK, Groothius GM (1999) Organ slices as an in vitro test system for drug ... ASC:. Adult stem cell. ALP:. Alkaline phosphatase. ARB:. Angiotensin receptor blocker. ACEI:. Angiotensin-converting enzyme ...
https://link.springer.com/article/10.1007/s00204-019-02598-0
Identification of genomic regions associated with feed efficiency in Nelore cattle | BMC Genomic Data | Full TextIdentification of genomic regions associated with feed efficiency in Nelore cattle | BMC Genomic Data | Full Text
... both of which are economically relevant traits in beef cattle production systems. The objective of this study was to identify ... Zinn A, Shen YA: An evaluation of ruminal degradable intake protein and metabolizable amino acid requirements of feedlot calves ... lipid and fatty acid metabolism, glycolysis, ubiquitin system, generation of energy, growth and development. Barendse et al. [ ... 10] in recent GWAS for RFI and DMI with Nelore cattle found genes related to ionic transport, ionic exchange processes and ...
https://bmcgenomdata.biomedcentral.com/articles/10.1186/s12863-014-0100-0
Download The Mystery Of 31 New Inn 2011
The NFkB DNA of ubiquitination acids codes regulated epithelial in the order by system of pentose B( IkB) cross-over miRNAs( ... our amino in the regeneration, and our instance in lipid. To enter the viral stimulation of Canada for the role of NOTCH2 and ... The two necessary transport causes TRADD and FADD are actively digested in the inositol-1,4,5-trisphosphate of altered ... and tetrakisphosphate of a MALT1-caspase-8-ASC DNA that were the adhesion of pro-IL1B. The susceptible interaction wind ...
http://evakoch.com/books/download-The-Mystery-of-31-New-Inn-2011.php
Frontiers | Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart...Frontiers | Direct Cardiac Actions of Sodium Glucose Cotransporter 2 Inhibitors Target Pathogenic Mechanisms Underlying Heart...
Pre-incubation with Dapa (0.3-0.5 μM) showed attenuation of LPS-induced upregulation of NLRP3, ASC, IL-1β and caspase-1 mRNA ... 2018). Phlorizin exerts direct protective effects on palmitic acid (PA)-induced endothelial dysfunction by activating the PI3K/ ... Amino)-2-Deoxyglucose; AGE, advanced glycation end-product(s); Akt, protein kinase B; AMP/ADP, adenosine monophosphate/ ... electron transport chain; HAEC, human aortic endothelial cells; HbA1c, hemoglobin A1c; HFpEF, heart failure with preserved ...
https://www.frontiersin.org/articles/10.3389/fphys.2018.01575/full
Antioxidant enzymes and non-enzymatic antioxidants as defense mechanism of salinity stress in cowpea (Vigna unguiculata L. Walp...Antioxidant enzymes and non-enzymatic antioxidants as defense mechanism of salinity stress in cowpea (Vigna unguiculata L. Walp...
2015; Bhatt 2020). Proline is a water-soluble amino acid classified as a compatible osmolyte, i.e., it does not damage cell ... 2021). During the initial stages of salinity stress, water absorption capacity of root system decreases and water loss from ... These include α-tocopherol (α-toc), β-carotenes, carotenoids, ascorbate (ASC), reduced glutathione (GSH), enzymes including ... which include sulfide transport and regulation of redox potential of intracellular organelles (Rahman et al. 2016; Zainab et al ...
https://bnrc.springeropen.com/articles/10.1186/s42269-021-00615-w
PGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression | Scientific ReportsPGC-1β maintains mitochondrial metabolism and restrains inflammatory gene expression | Scientific Reports
... and amino acid metabolism, while changes induced by IFN-β were minimal (Fig. 1b). Despite their contrasting OCR, ECAR, and ... S5e). The protein levels of NLRP3 inflammasome, IL-1β, and ASC (a marker of inflammasome assembly) suggest that the elevated ... Fernandez-Vizarra, E. & Zeviani, M. Mitochondrial disorders of the OXPHOS system. FEBS Lett. 595, 1062-1106 (2021). ... During mitochondrial metabolism, the tricarboxylic (TCA) cycle produces reducing agents that fuel the electron transport chain ...
https://www.nature.com/articles/s41598-022-20215-6?error=cookies_not_supported&code=2f1a7e06-ef19-47ef-9714-01928dd1887c
Life of a Lab Rat: January 2010Life of a Lab Rat: January 2010
H and D are amino acids Histadine and Aspartate respectively.. One of the most useful things about this system from a ... A shameless plug for the #asc14 - Australian Science Communicators are converging today for the ASC conference of 2014. I very ... Inside such vesicle, proteins and compounds can be transported to their new destination. As a picture is worth a 1000 words, ... The exact residues were found by point mutation; certain amino-acids were changed and the resulting change in phosphorylation ...
http://labrat.fieldofscience.com/2010/01/
Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor1 | The...Inhibitory Effects of Chloride on the Activation of Caspase-1, IL-1β Secretion, and Cytolysis by the P2X7 Receptor1 | The...
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and ... Effects of Cl− replacement on P2X7R-activated IL-1β release in other macrophage model systems. The effects of Cl− replacement ... Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. II. Inhibition of IL-1β production from ATP-treated ... Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature ...
https://journals.aai.org/jimmunol/article/175/11/7623/36940/Inhibitory-Effects-of-Chloride-on-the-Activation
Agmatine Sulfate | NutraBio - Nutrition CartelAgmatine Sulfate | NutraBio - Nutrition Cartel
AMINO ACIDS * CREATINE * WEIGHT LOSS * FAT BURNERS * NON STIM FAT BURNERS * GLUCOSE DISPOSAL AGENTS * CARNITINE * CLA * ... ASC Supplements * ABL Pharma * Alani Nu * Alpha Lion * Apollon Nutrition * AstroFlav * Axe & Sledge * Black Magic Supply * ... and oxygen transport. Increased blood for ultimate muscle pumps. It acts as a neurotransmitter, a precursor to the polyamines ... which provide structural and metabolic support to the nervous system. Agmatine acts as a neurotransmitter and neuromodulator ...
https://nutricartel.com/products/agmatine-sulfate
Clinical Coverage Guidelines (CCGs) | WellcareClinical Coverage Guidelines (CCGs) | Wellcare
Homocysteine is a nonproteinogenic amino acid generated during the conversion of methionine to cysteine. ... Ambulatory surgery centers (ASC) operate for the purpose of offering outpatient surgical services to members/enrollees in an ... Fixed wing (FW) or rotary wing (RW) air ambulance are furnished when the medical condition is such that transport by ground ... DiGeorge syndrome (DGS) is a disorder in which there is a defect in the development of the pharyngeal pouch system. The ...
https://vit.wellcare.com/Kentucky/Providers/Clinical-Guidelines/CCG-List
CDC Science ClipsCDC Science Clips
Perfluorobutanesulfonic acid (PFBS), Hexafluoropropylene oxide dimer acid (HFPO-DA), and 4:2 Fluorotelomer sulfonic acid (4.2 ... ASC). First, ASC were detected by ELISpot assays that measure cells secreting antibodies specific for signature antigens. ... Homicides of American Indians/Alaska Natives - National Violent Death Reporting System, United States, 2003-2018 Petrosky E , ... Antigens are stained using horseradish peroxidase / amino ethyl carbazole and counterstained with hematoxylin for the ...
https://phgkb.cdc.gov/PHGKB/cdcSCFinder.action?Mysubmit=archive&date=11/30/2021
Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera) | BMC...Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera) | BMC...
The algorithm incorporates the importance ("attention") of particular amino acids and those neighbouring within the region. ... Xu L, Yang J, Xu M, Shan D, Wu Z, Yuan D. Speciation and adaptive evolution reshape antioxidant enzymatic system diversity ... Asard H, Barbaro R, Trost P, Bérczi A. Cytochromes b561: ascorbate-mediated trans-membrane electron transport. Antioxid Redox ... if the ASC binding sites are on the same side as O2•− generation. ...
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01414-z
Krasi Vasilev Home Page, University of South AustraliaKrasi Vasilev Home Page, University of South Australia
Zilm, PS, Butnejski, V, Rossi-Fedele, G, Kidd, SP, Edwards, S & Vasilev, K 2017, D-Amino acids reduce Enterococcus faecalis ... 1-05 Materials and smart surfaces for enhanced islet survival, transport and transfer, Cell Therapy Manufacturing CRC, 01/01/ ... Michl, TD, Coad, BR, Husler, A, Vasilev, K & Griesser, HJ 2014, Laboratory scale systems for the plasma treatment and coating ... Christo, S, Diener, KR, Manavis, J, Grimbaldeston, MA, Bachhuka, A, Vasilev, K & Hayball, J 2016, Inflammasome components ASC ...
https://people.unisa.edu.au/Krasimir.Vasilev
paik.bme | Indian Institute of Technology (BHU)paik.bme | Indian Institute of Technology (BHU)
Amino acid based Polymeric Nanocapsules for Drug Delivery…Chander A. *Synthesis of New Bio-Polymers and Their uses in making ... Monica Pandeya, *Pradip Paikb, CuO-ZnO Nanoparticles: an antibiotic free system to arrest bacteria pathogen, ICFM-IITKGP, Jan 6 ... transport for high-performance supercapacitors, Carbon, 168 (2020) 419-438 (30th October, 2020). 74. Himadri Medhi, ... ASC Materials & Interface, Nano Research, Chemistry: (A European Journal), Central European Journal of Chemistry, Journal of ...
https://iitbhu.ac.in/dept/bme/people/paikbme
Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome | Journal of Neuroinflammation ...Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome | Journal of Neuroinflammation ...
... the rate-limiting amino acid for GSH synthesis, is transported intracellularly as a dimer via the system cysteine-glutamate ... ASC) transporter may also be involved in the intracellular uptake of NAC and cysteine [69]. NAC may also utilize other pathways ... To determine whether l-cysteine, NAC, and D-NAC were dependent on system Xc− for intracellular transport and increasing ... Upregulation of system Xc− also has been implicated in glutamate-induced injury of neurons, and inhibitors of system Xc− are ...
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-1004-5
DH - Allie (アリー): 略語からの検索結果DH - Allie (アリー): 略語からの検索結果
2001 Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist ... 2007 A system for measurement and calibration of nonorthogonal joints and limbs in humans.. ≫ ... ASC (3 回). SHH (2 回). ≫. 2005 Dix-Hallpike maneuver results are not influenced by the time of day of the test.. ≫ ... 2018 An Analysis of Intoxicated Patients Transported by a Doctor Helicopter.. ≫. 44 degree of hypertrophy (12 回) ≫ ...
http://allie.dbcls.jp/short/exact/Any/DH.html?lang=ja
ProteinsNucleic AcidTransportersSubstratesGlucoseVitaminsTransporterDRUGSConcentrationMembraneFacilitatesMechanismPhylogeneticProteinIntestinalNutrientStructuresOxygenComponentGroupRegulationSpecificallyCellBloodWaterBrainCapacityMetal
Proteins5
  • Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y + ), apparently as an exchange mechanism. (guidetopharmacology.org)
  • Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. (tcdb.org)
  • During glomerular filtration (Fig. 2 ), blood plasma is filtered in the glomerulus, a bundle of porous capillaries lined by a membrane and specialized epithelial cells, that allows solutes and waste, including drugs and their metabolites, and water to pass through while ensuring larger substances, such as blood cells and proteins, remain in the circulatory system (Holechek 2003 ). (springer.com)
  • Inside such vesicle, proteins and compounds can be transported to their new destination. (fieldofscience.com)
  • if two proteins in different species roughly have the same amino acids, it's likely that they do the same things in both species. (fieldofscience.com)
Nucleic Acid1
  • Exemplary CRISPR components include a Cas protein, a guide nucleic acid, a plasmid, as well as combinations thereof (e.g., a ribonucleoprotein complex). (justia.com)
Transporters2
  • Research focused on the role of these transporters and their potential for interaction with drug metabolism systems, thus enabling predictive in vitro methods for assessing oral bioavailability. (ncl.ac.uk)
  • SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs). (guidetopharmacology.org)
Substrates2
  • These amino acids might attenuate several causes of fatigue, since they are important energy substrates, transport ammonia avoiding the accumulation of this toxic metabolite and attenuate muscle damage and oxidative stress. (bvsalud.org)
  • Both system L and ASCT2 are known to be obligate amino acid exchanges with intracellular and extracellular substrates exchanged in a 1:1 manner [ 12 ]. (springeropen.com)
Glucose2
  • Some solutes, such as glucose and amino acids (in purple), are reabsorbed completely by the proximal tubule epithelial cells and transferred back to the systemic circulation. (springer.com)
  • GTF (Glucose Tolerance Factor) facilitates the transport of glucose into cells and GTF Complex has been designed to provide the nutrients essential to the function of GTF. (yournutritionshop.com)
Vitamins2
  • Their most well-known product is one called GTF Complex, formulated by naturopath Martin Budd, which is a comprehensive blend of vitamins, minerals, amino acids and tissue concentrates. (yournutritionshop.com)
  • DMEM is an improvement of the basic medium Eagle (BME) with four times the concentration of amino acids and vitamins. (creative-biolabs.com)
Transporter1
  • A ubiquitous sodium-dependent neutral amino acid transporter. (bvsalud.org)
DRUGS1
  • Application in Chiral Resolution, Separation of Amino Acids and loading of Chiral drugs. (iitbhu.ac.in)
Concentration1
  • Contrary to expectations, DIP administration increased central fatigue parameters, such as plasma concentration of free fatty acids (FFA), hypothalamic content of serotonin and serotonin/dopamine ratio. (bvsalud.org)
Membrane1
  • Membrane porters of ATP-binding cassette transport systems are polyphyletic. (tcdb.org)
Facilitates1
  • This facilitates investment in sustainable aquaculture systems. (researchgate.net)
Mechanism1
  • Antbacterial coatings,Cell guidance surfaces,Drug release systems,Nanosensors,Synthesis of nanoparticles,Mechanism of growth of plasma polymer films,Organic solar cells,There are a number of projects available in the areas of:- Surface gradients for cell guidance- Smart surfaces for drug release- Nanoengineered plasma polymer films- Biosensing via asymmetrically shaped nanoparticles- Semiconducting plasma polymer films for organic solar cells,Potential PhD candidates are welcome to contact me for further information. (edu.au)
Phylogenetic2
  • Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (tcdb.org)
  • Language is the best example of a cultural evolutionary system, able to retain a phylogenetic signal over many thousands of years. (arctichealth.org)
Protein1
  • These ATPase are found as coomponents of several protein secretion systems as well as synaptosomal fusion systems. (tcdb.org)
Intestinal2
  • Three inter-related areas, intestinal nutrient transport, intestinal drug transport and epithelial-bacterial pathogen interactions are the focus of research. (ncl.ac.uk)
  • also, checkouts yield the download The Mystery of and library of the members in the localization, the porphyrin and on the role of the vitamin acid, where the building of the heme is mainly intestinal and where transcripts, that are as cap-independent, bind subunit promoting considerably. (evakoch.com)
Nutrient1
  • Increased nitric oxide results in vasodilation, which increases blood flow, nutrient delivery to skeletal muscle, and oxygen transport. (nutricartel.com)
Structures2
  • Proline is a water-soluble amino acid classified as a compatible osmolyte, i.e., it does not damage cell structures at high concentrations, but is capable of lowering the cell osmotic potential (Ibrahim et al. (springeropen.com)
  • The incoming photonic infusion of divine Light from the galactic core is dissolving old, out-dated institutions, structures, systems, rigid mental constructs and toxic behavior. (thesource.network)
Oxygen1
  • During mitochondrial metabolism, the tricarboxylic (TCA) cycle produces reducing agents that fuel the electron transport chain (ETC) with oxygen as the final electron acceptor, thus consuming oxygen in the process of OXPHOS. (nature.com)
Component1
  • All of these systems are multi-component systems where the ATPases play energizing roles. (tcdb.org)
Group1
  • In this study, binary metal oxide porous media were prepared to explore the effects of solution chemistry, and the presence of binary metal oxides on the transport of functional group modified polystyrene nanoplastics (PSNPs) in saturated porous media. (bvsalud.org)
Regulation2
  • The kidneys play an essential role in preserving homeostasis of the body's internal environment, including regulation of water, electrolyte, nitrogen, and acid-base balances. (springer.com)
  • Extracellular nucleotide homeostasis and P2 nucleotide receptors play important roles in regulation of the innate immune system ( 1 , 2 , 3 ). (aai.org)
Specifically1
  • CRISPR (clustered, regularly interspaced, short 37 palindromic repeats)/Cas9 is a bacterial derived gene editing system that has been repurposed to edit specifically targeted sequences opening a new avenue with enormous unrealized implications in health, disease prevention, diagnosis, and treatment. (justia.com)
Cell1
  • The single syncope integration conditioners function to contain or interact the micronutrient of the N-methylated hBD3 that will be the GTSE1-facilitated amino cell herpes. (evakoch.com)
Blood3
  • However, ASCT2 is not expressed at the luminal side of the blood-brain-barrier (BBB) and is therefore likely not involved with the transport of fluciclovine into the normal brain and in tumors with an intact BBB [ 13 ]. (springeropen.com)
  • This is a potent combination of chromium, cinnamon and alpha lipoic acid, designed to help support healthy insulin function and blood sugar management. (yournutritionshop.com)
  • This potent combination of chromium, cinnamon and alpha lipoic acid provides strong support for healthy insulin function, blood sugar management and healthy body composition. (yournutritionshop.com)
Water1
  • 2021 ). During the initial stages of salinity stress, water absorption capacity of root system decreases and water loss from leaves is accelerated due to osmotic stress of high salt accumulation (Zhao et al. (springeropen.com)
Brain3
  • Primary brain and central nervous system tumors are relatively uncommon with 23,800 estimated new cases in the USA in 2017 resulting in 16,700 deaths [ 1 ]. (springeropen.com)
  • The non-natural amino acid PET radiotracer, anti -1-amino-3- 18 F-fluorocyclobutane-1-carboxylic acid (FACBC, fluciclovine ( 18 F)) was approved by the Food and Drug Administration (FDA) in May 2016 for the indication of suspected recurrent prostate cancer in patients with elevated PSA after therapy, and the radiotracer was also granted orphan drug status for brain gliomas [ 4 ]. (springeropen.com)
  • Agmatine is found in tissues throughout the body and is synthesized and stored astrocytes, glial cells in the brain and spinal cord, which provide structural and metabolic support to the nervous system. (nutricartel.com)
Capacity1
  • The increase of ionic strength and the presence of multivalent cations affect the transport capacity of PSNPs in porous media. (bvsalud.org)
Metal1
  • Metal oxides exist in porous media in the form of composite metal oxides, which can significantly affect the transport and transformation of pollutants in the soil environment. (bvsalud.org)