Amino Acid Transport Systems
Tsuga
Amino Acid Transport Systems, Basic
Amino Acids
Biological Transport
Aminoisobutyric Acids
Amino Acid Transport System A
Amino Acid Transport Systems, Neutral
Biological Transport, Active
Amino Acid Transport System ASC
Tungiasis
beta-Alanine
An amino acid formed in vivo by the degradation of dihydrouracil and carnosine. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. A rare genetic disorder, hyper-beta-alaninemia, has been reported.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Carrier Proteins
Sodium
Phenylalanine
Alanine
Membrane Transport Proteins
4-Chloromercuribenzenesulfonate
Glutamine
Proline
Cystine
Isoleucine
Fatty Acid Transport Proteins
Valine
Amino Acid Sequence
Cloning, Molecular
Mutation
Cell Membrane
High Vocal Center
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sequence Homology, Amino Acid
Hydrogen-Ion Concentration
Tryptophan
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Glutamates
Xenopus laevis
Substrate Specificity
Oocytes
Base Sequence
Taurocholic Acid
Rats, Inbred Strains
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Large Neutral Amino Acid-Transporter 1
Cells, Cultured
Glycine
Antigens, CD98 Light Chains
Cystinuria
An inherited disorder due to defective reabsorption of CYSTINE and other BASIC AMINO ACIDS by the PROXIMAL RENAL TUBULES. This form of aminoaciduria is characterized by the abnormally high urinary levels of cystine; LYSINE; ARGININE; and ORNITHINE. Mutations involve the amino acid transport protein gene SLC3A1.
Liver
Antigens, CD98 Heavy Chain
A transmembrane glycoprotein subunit that can dimerize with a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS). This protein subunit serves a diverse array of functions including amino acid transport and cell fusion. Its function is altered depending which of the light chain subunits it interacts with.
Hartnup Disease
An autosomal recessive disorder due to defective absorption of NEUTRAL AMINO ACIDS by both the intestine and the PROXIMAL RENAL TUBULES. The abnormal urinary loss of TRYPTOPHAN, a precursor of NIACIN, leads to a NICOTINAMIDE deficiency, PELLAGRA-like light-sensitive rash, CEREBELLAR ATAXIA, emotional instability, and aminoaciduria. Mutations involve the neurotransmitter transporter gene SLC6A19.
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Glucose
Carbon Radioisotopes
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Ileum
Membrane Proteins
Pseudomonadaceae
Phenylacetates
Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID.
Cycloheximide
Symporters
Ion Transport
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Protein Transport
DNA, Complementary
Axonal Transport
Amino Acid Transport System X-AG
Monosaccharide Transport Proteins
Stereoisomerism
Carbon Isotopes
Aspartic Acid
Amino Acid Transport Disorders, Inborn
Disorders characterized by defective transport of amino acids across cell membranes. These include deficits in transport across brush-border epithelial cell membranes of the small intestine (MICROVILLI) and KIDNEY TUBULES; transport across the basolateral membrane; and transport across the membranes of intracellular organelles. (From Nippon Rinsho 1992 Jul;50(7):1587-92)
Amino Acids, Essential
Placenta
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
Cyanides
Temperature
Binding Sites
Ouabain
Models, Biological
Glutamic Acid
Structure-Activity Relationship
3-O-Methylglucose
Jejunum
Rabbits
Mutagenesis, Site-Directed
Cationic Amino Acid Transporter 1
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Saccharomyces cerevisiae
Plasmids
Amino Acid Motifs
Kidney
Electron Transport
Serine
Protein Binding
Nitrogen
Insulin
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
ATP-Binding Cassette Transporters
Taurine
Organic Anion Transporters
Intestine, Small
Anion Transport Proteins
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Genetic Complementation Test
Models, Molecular
Maltose
Radioisotope Dilution Technique
Trophoblasts
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Kidney Cortex
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Gene Expression
Genes
DNA Primers
Depression, Chemical
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
Anions
Fatty Acids
Sequence Homology, Nucleic Acid
Cricetinae
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Protein Biosynthesis
Lithium
Cations
Iodoacetates
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Intestines
Cattle
Recombinant Fusion Proteins
Neurospora
Organic Anion Transporters, Sodium-Dependent
Threonine
Adenosine Triphosphate
Bile Acids and Salts
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
Bile Canaliculi
Chromosome Mapping
Binding, Competitive
Restriction Mapping
Tissue Distribution
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Gene Library
Transfection
Erythrocytes
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Peptide Fragments
Osmolar Concentration
Glutamate Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that couple the uptake of GLUTAMATE with the import of SODIUM ions and PROTONS and the export of POTASSIUM ions. In the CENTRAL NERVOUS SYSTEM they regulate neurotransmission through synaptic reuptake of the excitatory neurotransmitter glutamate. Outside the central nervous system they function as signal mediators and regulators of glutamate metabolism.
Carcinoma, Ehrlich Tumor
Periplasmic Binding Proteins
Blood-Brain Barrier
Intestinal Mucosa
Electrophoresis, Polyacrylamide Gel
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Tyrosine
Blotting, Northern
Epithelium
Succinates
Cell Membrane Permeability
Sequence Analysis, DNA
Xenopus
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Gene Expression Regulation
RNA, Complementary
Cation Transport Proteins
Sodium-Potassium-Exchanging ATPase
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Dose-Response Relationship, Drug
Glucagon
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
A novel system A isoform mediating Na+/neutral amino acid cotransport. (1/100)
A cDNA clone encoding a plasma membrane alanine-preferring transporter (SAT2) has been isolated from glutamatergic neurons in culture and represents the second member of the system A family of neutral amino acid transporters. SAT2 displays a widespread distribution and is expressed in most tissues, including heart, adrenal gland, skeletal muscle, stomach, fat, brain, spinal cord, colon, and lung, with lower levels detected in spleen. No signal is detected in liver or testis. In the central nervous system, SAT2 is expressed in neurons. SAT2 is significantly up-regulated during differentiation of cerebellar granule cells and is absent from astrocytes in primary culture. The functional properties of SAT2, examined using transfected fibroblasts and in cRNA-injected voltage-clamped Xenopus oocytes, show that small aliphatic neutral amino acids are preferred substrates and that transport is voltage- and Na(+)-dependent (1:1 stoichiometry), pH-sensitive, and inhibited by alpha-(methylamino)isobutyric acid (MeAIB), a specific inhibitor of system A. Kinetic analyses of alanine and MeAIB uptake by SAT2 are saturable, with Michaelis constants (K(m)) of 200-500 microm. In addition to its ubiquitous role as a substrate for oxidative metabolism and a major vehicle of nitrogen transport, SAT2 may provide alanine to function as the amino group donor to alpha-ketoglutarate to provide an alternative source for neurotransmitter synthesis in glutamatergic neurons. (+info)Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytes. (2/100)
The recently cloned amino acid transporter SAT2 is ubiquitously expressed and confers Na(+)-dependent transport of short-chain neutral amino acids, characteristics of the functionally defined System A transporter. Here we report the presence of SAT2 mRNA and protein in both skeletal muscle and adipocytes, and the characterization of polyclonal antibodies directed against this transporter. SAT2 protein was present in both plasma-membrane and internal-membrane fractions derived from rat skeletal muscle and adipose tissue, L6 myotubes and 3T3-L1 adipocytes, having a localization similar to that of the glucose transporter GLUT4. Moreover, consistent with the adaptive up-regulation of System A activity following chronic amino acid deprivation, a time-dependent increase in SAT2 protein abundance was observed in amino-acid-deprived L6 myotubes and 3T3-L1 adipocytes. These studies provide the first evidence regarding the subcellular distribution and adaptive up-regulation of SAT2 protein and the characterization of molecular probes for this physiologically important transporter, the function of which is altered in several disease states. (+info)Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport. (3/100)
We report here on the characterization of a mouse N-system amino acid transporter protein, which is involved in the transport of glutamine. This protein of 485 amino acids shares 52% sequence homology with an N-system amino acid transporter, mouse N-system amino acid transporter (mNAT) and its orthologs. Because this protein shares a high degree of sequence homology and functional similarity to mNAT, we named it mNAT2. mNAT2 is predominately expressed in the retina and to a slightly lesser extent in the brain. In the retina, it is located in the axons of ganglion cells in the nerve fiber layer and in the bundles of the optic nerve. Functional analysis of mNAT2 expressed in Xenopus oocytes revealed that the strongest transport activities were specific for l-glutamine. In addition, mNAT2 is a Na(+)- and pH-dependent, high affinity transporter and partially tolerates substitution of Na(+) by Li(+). Additionally, mNAT2 functions as a carrier-mediated transporter that facilitates efflux. The unique expression pattern and selective glutamine transport properties of mNAT2 suggest that it plays a specific role in the uptake of glutamine involved in the generation of the neurotransmitter glutamate in retina. (+info)Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression. (4/100)
Transforming growth factor-beta1 (TGF-beta 1) is a multifunctional cytokine that contributes to arterial remodelling by stimulating vascular smooth muscle cell (SMC) growth and collagen synthesis at sites of vascular injury. Since l-proline is essential for the synthesis of collagen, we examined whether TGF-beta 1 regulates the transcellular transport of l-proline by vascular SMCs. l-Proline uptake by vascular SMCs was primarily sodium-dependent, pH-sensitive, blocked by neutral amino acids and alpha-(methylamino)isobutyric acid, and exhibited trans-inhibition. Treatment of SMCs with TGF-beta 1 stimulated l-proline transport in a concentration- and time-dependent manner. The TGF-beta 1-mediated l-proline uptake was inhibited by cycloheximide or actinomycin D. Kinetic studies indicated that TGF-beta 1-induced l-proline transport was mediated by an increase in transport capacity independent of any changes in the affinity for l-proline. TGF-beta 1 stimulated the expression of system A amino acid transporter 2 (SAT2) mRNA in a time-dependent fashion that paralleled the increase in l-proline transport. Reverse transcriptase PCR failed to detect the presence of SAT1 or amino acid transporter 3 (ATA3) in either untreated or TGF-beta 1-treated SMCs. These results demonstrate that l-proline transport by vascular SMCs is mediated predominantly by the SAT and that TGF-beta 1 stimulates SMC l-proline uptake by inducing the expression of the SAT2 gene. The ability of TGF-beta 1 to induce SAT2 expression may function to provide SMCs with the necessary levels of l-proline required for collagen synthesis and cell growth. (+info)Physiological importance of system A-mediated amino acid transport to rat fetal development. (5/100)
Fetal growth and development are dependent on the delivery of amino acids from maternal amino acid pools to the fetal blood. This is accomplished via transfer across the apical and basal plasma membrane of the placental syncytiotrophoblast. The aim of this study was to determine whether inhibition of system A (amino acid transporter) was associated with a decrease in fetal weight in the rat. System A is a ubiquitous Na(+)-dependent amino acid transporter that actively transports small zwitterionic amino acids. In brief, system A was inhibited by infusing a nonmetabolizable synthetic amino acid analog, 2-(methylamino)isobutyric acid from days 7-20 of gestation. On day 20, the rats were killed and tissues (maternal liver, fetuses, and placentas) were collected for analysis. The degree of system A inhibition was determined, as was the impact of said inhibition on fetal and maternal weights, system A-mediated placental transport, and placental system A-mediated transporter expression. Our results suggest that when system A is inhibited, fetal weight is diminished [control group: -3.55 +/- 0.04 g (n = 113), experimental group: -3.29 +/- 0.04 g (n = 128)], implying an integral role for system A transport in fetal growth and development in the rat. (+info)Glutamine uptake by neurons: interaction of protons with system a transporters. (6/100)
Astrocytes provide the glutamine required by neurons to synthesize glutamate and GABA. However, the mechanisms involved in glutamine transfer from glia to neurons have remained poorly understood. Recent work has implicated the System N transporter SN1 in the efflux of glutamine from astrocytes and the very closely related System A transporters SA1 and SA2 in glutamine uptake by neurons. To understand how these closely related proteins mediate flux in different directions, we have examined their ionic coupling. In contrast to the electroneutral exchange of H+ for Na+ and neutral amino acid catalyzed by SN1, we now show that SA1 and SA2 do not couple H+ movement to amino acid flux. As a result, SA1 and SA2 are electrogenic and do not mediate flux reversal as readily as SN1. Differences between System N and A transporters in coupling to H+ thus contribute to the delivery of glutamine from glia to neurons. Nonetheless, although they are not transported, H+ inhibit SA1 and SA2 by competing with Na+. (+info)Localization and functional relevance of system a neutral amino acid transporters in cultured hippocampal neurons. (7/100)
Glutamine and alanine are important precursors for the synthesis of glutamate. Provided to neurons by neighboring astrocytes, these amino acids are internalized by classical system A amino acid carriers. In particular, System A transporter (SAT1) is a highly efficient glutamine transporter, whereas SAT2 exhibits broad specificity for neutral amino acids with a preference for alanine. We investigated the localization and the functional relevance of SAT1 and SAT2 in primary cultures of hippocampal neurons. Both carriers have been expressed since early developmental stages and are uniformly distributed throughout all neuronal processes. However, whereas SAT1 is present in axonal growth cones and can be detected at later developmental stages at the sites of synaptic contacts, SAT2 does not appear to be significantly expressed in these compartments. The non-metabolizable amino acid analogue alpha-(methylamino)-isobutyric acid, a competitive inhibitor of system A carriers, significantly reduced miniature excitatory postsynaptic current amplitude in neurons growing on top of astrocytes, being ineffective in pure neuronal cultures. alpha-(Methylamino)-isobutyric acid did not alter neuronal responsitivity to glutamate, thus excluding a postsynaptic effect. These data indicate that system A carriers are expressed with a different subcellular distribution in hippocampal neurons and play a crucial role in controlling the astrocyte-mediated supply of glutamatergic neurons with neurotransmitter precursors. (+info)Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. (8/100)
SAT1-3 comprise members of the recently cloned family of System A transporters that mediate the sodium-coupled uptake of short chain neutral amino acids, and their activity is regulated extensively by stimuli such as insulin, growth factors, and amino acid availability. In skeletal muscle, insulin stimulates System A activity rapidly by a presently ill-defined mechanism. Here we demonstrate that insulin induces an increase in the plasma membrane abundance of SAT2 in a phosphatidylinositol 3-kinase-dependent manner and that this increase is derived from an endosomal compartment that is required for the hormonal activation of System A. Chloroquine, an acidotropic weak base that impairs endosomal recycling of membrane proteins, induced a complete inhibition in the insulin-mediated stimulation of System A, which was associated with a loss in SAT2 recruitment to the plasma membrane. The failure to stimulate System A and recruit SAT2 to the cell surface could not be attributed to a block in insulin signaling, as chloroquine had no effect on the insulin-mediated phosphorylation of protein kinase B or glycogen synthase kinase 3 or upon insulin-stimulated GLUT4 translocation and glucose transport. Our data indicate strongly that insulin increases System A transport in L6 cells by stimulating the exocytosis of SAT2 carriers from a chloroquine-sensitive endosomal compartment. (+info)The role of the neutral amino acid transporter SNAT2 in cell volume regulation.
6m17 - Proteopedia, life in 3D
long-chain fatty acid transporter activity QuickView - Correlation Engine
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PLOS Pathogens: Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport
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Modelling nutrient transfer across the placenta - ePrints Soton
Isobutyric acid, isobutenyl ester
Longitudinal distribution of arylamine N-acetyltransferases in the intestine of the hamster, mouse, and rat. Evidence for...
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Hyperosmotic stress up-regulates amino acid transport in vascular endothelial cells<...
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Association of arylamine N-acetyltransferases NAT1 and NAT2 genotypes to laryngeal cancer risk. - PubMed - NCBI
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Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 ...
Human Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19 (SLC6A19) Protein (GST tag), Recombinant | ABIN1320502
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4-{(1S)-1-Hydroxy-2-[(<sup>2</sup>H<sub>3</sub>)methylamino]ethyl}-1,2-benzenediol |...
Identification of a plasma membrane glutamine transporter from the rat hepatoma cell line H4-IIE-C3 | Biochemical Journal
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Sodium-coupled neutral amino acid transporter 2
Jones HN, Ashworth CJ, Page KR, McArdle HJ (2006). "Cortisol stimulates system A amino acid transport and SNAT2 expression in a ... "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is ... 2006). "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic ... 2006). "Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 ( ...
Sodium-dependent neutral amino acid transporter B(0)AT1
"Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder". J. ... SLC6A19 is a system B(0) transporter that mediates epithelial resorption of neutral amino acids across the apical membrane in ... Bröer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249-286. ... Sodium-dependent neutral amino acid transporter B(0)AT1 is a protein that in humans is encoded by the SLC6A19 gene. ...
Cationic amino acid transporter 3
... is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[ ... "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3". Hosokawa H, Sawamura T, ... Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene. SLC7A3 ... Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially ...
Enterocyte
Peptide and amino acid uptake. Peptidases in the glycocalyx cleave proteins to amino acids or small peptides. Enteropeptidase ( ... Galactose uses the same transport system. Fructose, on the other hand, crosses the apical membrane of the enterocyte, using ... This facilitates transport of numerous small molecules into the enterocyte from the intestinal lumen. These include broken down ... Smaller lipids are transported into intestinal capillaries, while larger lipids are processed by the Golgi and smooth ...
Gamma-Amino-beta-hydroxybutyric acid
... and l-γ-Amino-β-Hydroxybutyric Acids in GABA Receptor and Transport Test Systems". Journal of Neuroscience. 1 (2): 132-140. doi ... γ-Amino-β-hydroxybutyric acid (GABOB), also known as β-hydroxy-γ-aminobutyric acid (β-hydroxy-GABA), and sold under the brand ... Amino acids, Anticonvulsants, Beta hydroxy acids, GABA analogues, GABAA receptor agonists, GABAB receptor agonists, Human ... Effect of gamma-amino-beta-hydroxybutyric acid (GABHB) on experimentally-induced epileptic activity]" [Effect of γ-amino-β- ...
Phytotoxin
The plants are slowly starved of these amino acids and eventually DNA synthesis stops. ESPS Inhibitors affect grasses and ... They are medically important by interfering with components of the nervous system affecting membrane transport, protein ... ALS Inhibitors affect grasses and dicots by inhibiting the first step in some amino acid synthesis, acetolactate synthesis. ... Alkaloids are derived from amino acids, and contain nitrogen. ...
Neutral amino acid transporter B(0)
Kudo Y, Boyd CA (August 2002). "Changes in expression and function of syncytin and its receptor, amino acid transport system B( ... Neutral amino acid transporter B(0) is a protein that in humans is encoded by the SLC1A5 gene. Glutamate transporter Solute ... "Entrez Gene: SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5". Tailor CS, Nouri A, Zhao Y, Takeuchi Y ... Uchiyama T, Matsuda Y, Wada M, Takahashi S, Fujita T (April 2005). "Functional regulation of Na+-dependent neutral amino acid ...
Serotonin-norepinephrine reuptake inhibitor
Serotonin is synthesized from an amino acid called L-tryptophan. Active transport system regulates the uptake of tryptophan ... The same motif can be found in reboxetine where it is constrained in a morpholine ring system. Some studies have been made ... Although the perception and transmission of pain stimuli in the central nervous system have not been fully elucidated, ... TCAs do not block dopamine transport directly but might facilitate dopaminergic effects indirectly by inhibiting dopamine ...
Gamma-L-Glutamyl-L-cysteine
Orlowski, M.; Meister, A. (1970-11-01). "The Gamma-Glutamyl Cycle: A Possible Transport System for Amino Acids". Proceedings of ... It has a relatively unusual γ-bond between the constituent amino acids, L-glutamic acid and L-cysteine and is a key ... Control experiments with combinations of the constituent amino acids that make up GGC, including L-glutamic acid and L-cysteine ... GGC is synthesized from L-glutamic acid and L-cysteine in the cytoplasm of virtually all cells in an adenosine triphosphate ( ...
Metallothionein
Cysteine is a sulfur-containing amino acid, hence the name "-thionein". However, the participation of inorganic sulfide and ... Metallothioneins likely participate in the uptake, transport, and regulation of zinc in biological systems. Mammalian MT binds ... In this way thionein and metallothionein becomes a key component of the zinc signaling system in cells. This system is ... of its constituent amino acid residues. MT was discovered in 1957 by Vallee and Margoshe from purification of a Cd-binding ...
Angomonas deanei
It synthesises amino acids, vitamins, nitrogenous bases and haem for the protozoan. Haem is necessary for the growth and ... While the protozoan has its separate mitochondria that provide electron transport system for the production of cellular energy ... In return the protozoan offers its enzymes for the complete metabolic pathways for the biosynthesis of amino acids, lipids and ... and that it helps the host in synthesising the amino acid arginine from ornithine. As more structural and molecular details ...
Proton coupled amino acid transporter
HPAT1 and 2 are integral to the central nervous system because they transport GABA and its analogues which can induce and ... Unlike most amino acid transporters in the exchange of Na+ with amino acid symporters, proton-coupled amino acid transporters ... "Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)". Biochimica ... Unlike typical mammalian amino acid transporters which function in exchanging Na+/amino acid symporters, these- transporters ...
B(0,+)-type amino acid transporter 1
... a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. ... This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids ... b(0,+)-type amino acid transporter 1, also known as b(0,+)AT1, is a protein which in humans is encoded by the SLC7A9 gene. This ... Heterodimeric amino acid transporter Solute carrier family GRCh38: Ensembl release 89: ENSG00000021488 - Ensembl, May 2017 ...
Gary Ackers
Ackers GK (1969). "Molecular sieve studies of interacting protein systems. IV. Molecular size of the D-amino acid oxidase ... Ackers GK (1967). "Molecular sieve studies of interacting protein systems. I. Equations for transport of associating systems". ... thermodynamics of protein-protein interactions including important changes due to single amino acid substitutions. "Obituary - ...
Neutral and basic amino acid transport protein rBAT
AT heterodimer is the main apical reabsorption system for cystine in the kidney". Am. J. Physiol. Renal Physiol. 283 (3): F540- ... amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter". J. Biol. Chem. 275 (19): 14331- ... dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1". Pras E ... of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport ...
Arc system
This inorganic phosphate is then transfered via a four amino acid phosphorelay to ArcA. Phosphorylated ArcA is then able to ... The Arc system connects the electron transport chain to regulation of certain genes, allowing aerobic respiration to occur in ... The Arc system is a two-component system found in some bacteria that regulates gene expression in faculatative anaerobes such ... Arc is an abbreviateion for Anoxic Redox Control system. Arc systems are instrumental in maintaining energy metabolism during ...
Transgenerational trauma
von Versen-Höynck, F.; Rajakumar, A.; Parrott, M.S.; Powers, R.W. (April 2009). "Leptin Affects System A Amino Acid Transport ... Amino acid transport is also regulated by DNA methylation of amino acid transporter genes, modifying their expression in the ... trigger the regulation of amino acid transporters in the placenta. Amino acid transport is necessary for fetal growth, and its ... "A systems perspective on placental amino acid transport". The Journal of Physiology. 596 (23): 5511-5522. doi:10.1113/JP274883 ...
Importin subunit alpha-4
... encodes a protein similar to certain nuclear transport proteins of Xenopus and human. The predicted amino acid sequence shows ... The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system. KPNA3 ... Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA3, ... The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex ( ...
SLC38A1
"Characterization of an N-system amino acid transporter expressed in retina and its involvement in glutamine transport". J. Biol ... Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene. Amino acid ... 2007). "Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic ... a subtype of amino acid transporter A, from human placenta". Biochem Biophys Res Commun. 273 (3): 1175-9. doi:10.1006/bbrc. ...
Central nervous system fatigue
The transport mechanism for tryptophan is shared with the branched chain amino acids (BCAAs), leucine, isoleucine, and valine. ... amino acid and carbohydrate supplementation on the exercise-induced change in plasma and muscle concentration of amino acids in ... Branch-chained amino acid supplementation has proven to have little to no effect on performance. There has been little success ... Amino acids, brain neurotransmitters and a functional link between muscle and brain that is important in sustained exercise. In ...
Plasmid partition system
The amino-acid sequence identity can go down to 15% between ParM and other actin-like ATPase. The mechanism of partition ... The net result being transport of partition complex to the cell pole. The partition system of the plasmid R388 has been found ... Amino-acid sequence identity can go down to 21% for TubZ proteins. The mechanism is similar to a treadmill mechanism: Multiple ... This system has been proposed to be the type IV partition system. It is thought to be a derivative of the type I partition ...
Azaserine
... heptane transport by O-diazoacetyl-L-serine. An initial step in identifying the L-system amino acid transporter". The Journal ... and research indicates that it may have potential in identifying the L-leucine-favoring system transporter in human T- ...
Endocrine system
Hormones can be amino acid complexes, steroids, eicosanoids, leukotrienes, or prostaglandins. The endocrine system can be ... A hormone is any of a class of signaling molecules produced by cells in glands in multicellular organisms that are transported ... The human endocrine system consists of several systems that operate via feedback loops. Several important feedback systems are ... The endocrine system has three sets of endocrine outputs which include the magnocellular system, the parvocellular system, and ...
Glutamate receptor
Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system and ... However, there is a possibility that two human-specific "fixed" amino acid substitutions, D71G in GRIN3A and R727H in GRIN3B, ... Weaver CD, Gundersen V, Verdoorn TA (January 1998). "A high affinity glutamate/aspartate transport system in pancreatic islets ... Meldrum B (1993). "Amino acids as dietary excitotoxins: a contribution to understanding neurodegenerative disorders". Brain Res ...
Small intestine
Sodium bicarbonate is absorbed by active transport and glucose and amino acid co-transport Fructose is absorbed by facilitated ... are an important part of the digestive tract's local immune system. They are part of the lymphatic system, and provide a site ... splits one amino acid at a time. Aminopeptidase and dipeptidase free the end amino acid products. Lipids (fats) are degraded ... The epithelial cells of the villi transport nutrients from the lumen of the intestine into these capillaries (amino acids and ...
Membrane transport protein
This transport system normally removes cysteine from the fluid destined to become urine and returns this essential amino acid ... This is usually to accumulate high concentrations of molecules that a cell needs, such as glucose or amino acids. If the ... Excitatory amino acid transporters (EAATs) EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 Glucose transporter Monoamine transporters, including ... Reverse transport, or transporter reversal, is a phenomenon in which the substrates of a membrane transport protein are moved ...
Chloroplast
... s carry out a number of other functions, including fatty acid synthesis, amino acid synthesis, and the immune ... Chloroplasts can pump K+ and H+ ions in and out of themselves using a poorly understood light-driven transport system. In the ... Chloroplasts synthesize all the fatty acids in a plant cell-linoleic acid, a fatty acid, is a precursor to jasmonate. One of ... Chloroplasts alone make almost all of a plant cell's amino acids in their stroma except the sulfur-containing ones like ...
Expanded genetic code
... various transport systems can handle unnatural amino acids with apolar side-chains. In the second case, a biosynthetic pathway ... while the added amino acids are called non-standard amino acids (NSAAs), or unnatural amino acids (uAAs; term not used in ... or non-canonical amino acids. The first element of the system is the amino acid that is added to the genetic code of a certain ... An amino acid auxotrophic expression host is supplemented with an amino acid analog during target protein expression. This ...
Reabsorption
However, glucose, amino acids, inorganic phosphate, and some other solutes are reabsorbed via secondary active transport ... Renin-angiotensin system: The kidneys sense low blood pressure. Release renin into the blood. Renin causes production of ... Reabsorption allows many useful solutes (primarily glucose and amino acids), salts and water that have passed through Bowman's ... This happens as a result of sodium transport from the lumen into the blood by the Na+/K+ATPase in the basolateral membrane of ...
Glutamate (neurotransmitter)
... but it is actively transported out of the nervous system by a high affinity transport system, which maintains its concentration ... Glutamate is a very major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in ... Smith QR (April 2000). "Transport of glutamate and other amino at the blood-brain barrier". The Journal of Nutrition. 130 (4S ... Glutamate is formally classified as a non-essential amino acid, because it can be synthesized (in sufficient quantities for ...
Regulation of Amino Acid Transport in Saccharomyces cerevisiae
Hence, the ,i,de novo,/i, synthesis reactions, metabolic conversions, and transport of amino acids are tightly regulat … ... Amino acid homeostasis is essential for cell growth and survival. ... We review the mechanisms responsible for amino acid homeostasis in ,i,Saccharomyces cerevisiae,/i, and other fungi. ... Amino Acid Sequence * Amino Acid Transport Systems / genetics * Amino Acid Transport Systems / metabolism* ...
Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression | Nature Metabolism
Amino acids are required for cell survival and growth. However, the different requirements of amino acid metabolic pathways in ... focus on the transporter of neutral amino acids and show that malignant blood cells rely more on ASCT2-mediated amino acid ... Here, we report that knockout of solute carrier family 1 member 5 (Slc1a5/ASCT2), a transporter of neutral amino acids, ... Given the substantial difference in reliance on ASCT2-mediated amino acid metabolism between normal and malignant blood cells, ...
IMSEAR at SEARO: Characterization of anionic amino acid transport systems in mouse mammary gland.
... there was no evidence for the heterogeneity of anionic amino acid transport system. The XAG- system was inhibited by sulfhydryl ... Kansal VK, Sharma R, Rehan G. Characterization of anionic amino acid transport systems in mouse mammary gland. Indian Journal ... L-glutamate was transported into mammary tissue via Na(+)-dependent system XAG- that strongly interacted with both D- and L- ... Although neutral amino acids weakly inhibited the uptake of L-glutamate, ...
Effect of cholesterol on the branched-chain amino acid transport system of Streptococcus cremoris. | J Bacteriol;170(7): 3194...
Effect of cholesterol on the branched-chain amino acid transport system of Streptococcus cremoris.. Zheng, T; Driessen, A J; ... The effect of cholesterol on the activity of the branched-chain amino acid transport system of Streptococcus cremoris was ... suggesting that the membrane fluidity controls the activity of the branched-chain amino acid carrier. ... The leucine transport activity decreased with the membrane fluidity, as determined by steady-state fluorescence polarization of ...
The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)<...
The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)」の研究トピックを掘り下げます。これらが ... The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-). Cancer Research. ... The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-). In: Cancer ... The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-). / Tsuchihashi, ...
Substrate recognition and transport behavior analyses of amino acid antiporter with coarse-grained models - Molecular...
... antiporter AdiC is a vital transport protein of the arginine-dependent extreme acid resistance system of enteric bacteria. ... antiporter AdiC is a vital transport protein of the arginine-dependent extreme acid resistance system of enteric bacteria. ... Substrate recognition and transport behavior analyses of amino acid antiporter with coarse-grained models S. Chang, J. Hu, P. ... Substrate recognition and transport behavior analyses of amino acid antiporter with coarse-grained models† ...
Excitatory Amino Acid Transporters
Sigma-Aldrich offers many products related to excitatory amino acid transporters for your research needs. ... sodium-dependent glutamate transport in the central nervous system., Curr. Pharm. Des.,5, 363-379 (1999).. ... In addition to the transport of L-glutamate, a number of other naturally occurring excitatory amino acids, including L- ... Excitatory amino acid transporters as emerging targets for central nervous system therapeutics. Emerging Therapeutic Targets. 3 ...
Mode of Action Video - Glossary - Alabama Cooperative Extension System
This enzyme is essential in amino acid or protein synthesis. Without proteins, plants starve to death. Enzyme blockers kill a ... Electron Inhibitors: Are pesticides that stop the transport of electrons with in a plant. ... 2022 by the Alabama Cooperative Extension System. All rights reserved.. www.aces.edu. This content printed from the website ... Systemic Mode of Action: The pesticide penetrating the plant or animal and translocating within its systems with the intent to ...
Lewy Body Dementia Medication: Cholinesterase Inhibitors, Antipsychotics, 2nd Generation, Antidepressants, Benzodiazepines,...
... neutral amino acid absorbed in the proximal small intestine by the saturable carrier-mediated transport system. Absorption is ... neutral amino acids (although only patients with meaningful motor fluctuations need to consider a low-protein or protein- ... By binding to specific receptor sites, these agents appear to potentiate the effects of gamma-aminobutyric acid (GABA) and to ... which may increase concentrations of ACh available for synaptic transmission in the central nervous system (CNS). ...
Pharmaceutics | Free Full-Text | Targeted Delivery of Epidermal Growth Factor to the Human Placenta to Treat Fetal Growth...
GPS-decorated liposomes containing EGF significantly increased amino acid transporter activity in healthy control explants, but ... Undecorated and GPS-decorated liposomes containing PBS did not affect the basal rate of amino acid transport, human chorionic ... Figure 5. Targeted delivery of EGF increases System A amino acid transport activity in human placental explants. Third- ... Figure 5. Targeted delivery of EGF increases System A amino acid transport activity in human placental explants. Third- ...
Alle Publikationen | Max-Planck-Institut für Molekulare Pflanzenphysiologie
Hesse, H.: Systems biology of inter- and intracellular metabolite transport in plants. In Amino Acids, 37, S. 46 - 46. (2009) ... Cuong, N. H.; Hesse, H.; Hoefgen, R.: Improvement of amino acid content in rice (O-sativa). In Amino Acids, 33 (3), S. Xxxv - ... van der Merwe, M. J.; Osorio, S.; Moritz, T.; Nunes-Nesi, A.; Fernie, A. R.: The role and regulation of the tricarboxylic acid ... Willmitzer, L.; Degenkolbe, T.; Caldana, C.; Hannah, M.: Systems response to environmental conditions as studied by metabolome ...
Nur H Alam's Research on Fluid Therapy (Oral Rehydration Therapy)
| CureHunter
What type of tissue transports water within a plant? - Erasingdavid.com
Plants have two transport systems - xylem and phloem . Xylem transports water and minerals. Phloem transports sugars and amino ... Xylem transports water and minerals. Phloem transports sugars and amino acids dissolved in water. ... What transports tissue in plants?. Plant transport tissues - xylem and phloem. Plants have two transport systems - xylem and ... Does the phloem transport water?. Plants have tissues to transport water, nutrients and minerals. Xylem transports water and ...
SciELO - Brazil - Performance of Japanese quails fed diets with low-protein and isoleucine Performance of Japanese quails fed...
Amino acids valine, isoleucine and leucine are known as BCAA (Branched Chain Amino Acids), and they compete with each other for ... All three are structurally similar, with branched chain and having the same transport systems, through cellular membranes, as ... Isoleucine is an essential amino acid of the family of aliphatic hydrophobic amino acids mainly found mainly in proteins and ... and the demand for protein and amino acids for its composition is high, i.e., the lack of protein or amino acids would result ...
Selenium - Food for the Brain
These forms follow the usual mechanisms of amino acid uptake from the digestive system. SeMet is transported to the liver bound ... The main transport of Se around the body occurs in the blood in the form of selenoprotein P (SELENOP). Selenium also binds to α ... Although SELENOP is the main selenoprotein and is important for transporting Se around the human body, it is not the only ... The perturbation of Se biochemistry and subsequent decrease in the supply of Se to the central nervous system may partly ...
Hartnup Disease: Practice Essentials, Background, Pathophysiology
... amino acid transport in the apical brush border membrane of the small intestine and the proximal tubule of the kidney. Patients ... Molecular cloning of mouse amino acid transport system B0, a neutral amino acid transporter related to Hartnup disorder. J Biol ... neutral amino acid transporter, causes a failure of the transport of neutral (ie, monoaminomonocarboxylic) amino acids in the ... 2, 4, 18] The B0 AT1 transporter is a sodium-dependent, chloride-independent system and transports all neutral amino acids in ...
Plus it
Biodistribution of 11C-methylaminoisobutyric acid, a tracer for PET studies on system A amino acid transport in vivo. Eur J ... reflecting the metabolic rate and the amino-acid tracer 11C-MeAIB reflecting the rate of the system A amino-acid transport-were ... a metabolically stable alanine analog targeting the system A amino-acid transport system, has a very low uptake in normal brain ... Human radiation dosimetry of 11C-MeAIB, a new tracer for imaging of system A amino acid transport. Eur J Nucl Med Mol Imaging. ...
Find Research outputs
- The University of Aberdeen Research Portal
Adaptive regulation of amino acid transport system A in BeWo cells. Thomas, H. N., Ashworth, C., Page, K. R. & McArdle, H. J., ... Ammonium N-(6-amino-3,4-dihydro-3-methyl-5-nitroso-4-oxopyrimidin-2-yl)glycinate monohydrate forms hydrogen-bonded bilayers. ... Clift, P. D., Schouten, H. & Draut, A. E., 2003, Intra-Oceanic Subduction Systems: Tectonic and Magmatic Processes (eds. Larter ... Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins. ...
Difference between revisions of "Aeropyrum pernix" - microbewiki
It is a heterotropth that uses various types of amino acids and sugars. It uses aerobic degradation of complex porteinaceous ... The ligopeptide transport systems, such as the dependent ATP-binding cassette (ABC) transporters, help these nutrients to ... It was thought that this enzyme was specific for hydrophobic amino acids and the S1 subsite, but further experiments showed ...
Science Clips - Volume 13, Issue 48, December 28, 2021
Thus, the preference for the use of some less energy costly amino acids in C. felis may lead to a more harmonious parasite-host ... and alternative electron transport systems and several invasion-related proteins. ... Thus, C. felis has a different codon usage, which increases the use of less energy costly amino acids (Gly and Ala) encoded by ... systems, 78.4% (40/51) of respondents rated TIM more favorably than their previous monitoring system, 19.6% (10/51) said there ...
Computational Biology - Research Outputs - Discovery - the University of Dundee Research Portal
Amino Acid Transport Systems 100% * Embryonic Structures 60% * Metabolic 59% * Morphogenesis 55% ... Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. Poncet, N., ... Liu, D., Albergante, L. & Newman, T. J., 7 Jul 2017, In: Nucleic Acids Research. 45, 12, p. 7078-7093 16 p.. Research output: ... Russell, R. B., Copley, R. R. & Barton, G. J., 1995, Proceedings of the 28th Annual Hawaii International Conference on System ...
From dust to, possibly, life: New experiments show complex astrochemistry on thin ice covering dust grains | Max Planck...
... such as the simple amino acid glycine. Over the course of the evolution of a planetary system, organic molecules can be ... transported to planetary surfaces by meteorites and early comets.. How those molecules can form in the first place, in the ... Molecules, including the organic molecules necessary to form amino acids, or our own DNA, can form in the interstellar medium. ...
Patent Docs: February 2016
... neutral or aromatic L-amino acids, and must rely on uptake of these essential amino acids. Aromatic amino acids phenylalanine ... The richer repertoire of membrane transport systems in Ae. aegypti is likely to intersect with the apparent increase in odorant ... Aedes aegypti encodes more members of 4 different types of amino acid transporters than An. gambiae and D. melanogaster. ... gambiae and 58% having an ortholog in D. melanogaster, with an average amino acid identity of 74% between the mosquito ...
Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter - Fingerprint
- Oregon Health &...
Basic Amino Acids 100% * Amino Acid Transport Systems 98% * Cell Surface Receptors 78% ... Dive into the research topics of Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter. ... Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter. ...
System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental...
... and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that ... and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that ... and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that ... and involvement of amino acid transport system A was proposed. Here, we aimed to identify the subtype(s) of system A that ...
Dietary whey protein increases liver and skeletal muscle glycogen levels in exercise-trained rats | British Journal of...
... leucine-induced up-regulation of system A amino acid transport. Biochem J 350 Pt 2 361-368.CrossRefGoogle Scholar ... Effects of crude protein intake from forage-only diets on muscle amino acids and glycogen levels in horses in training. Equine ... A dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in ... Branched-Chain Amino Acid-Containing Dipeptides, Identified from Whey Protein Hydrolysates, Stimulate Glucose Uptake Rate in L6 ...
Search Results For Health And Wellness: enormous Results found: 33
... abundance of sulphur containing amino acids and other compounds that seem to initiate increased activity in the immune system. ... as a contributor of power to the immune system] is that it picks up toxic materials and transports them out of the body."23 The ... Brain and Nervous System DMAE, Ginkgo, Carnosine, Bilberry, CoQ10, Grapeseed, Lipoic Acid, Vit B-2, Lutein Liver Lipoic Acid, N ... The immune system is unlike other body systems in that it is not a group of physical structures but a system of complex ...
Defective glutamate and K<sup>+</sup> clearance by cortical astrocytes in familial hemiplegic migraine...
Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment
M. Orlowski and A. Meister, "The gamma-glutamyl cycle: a possible transport system for amino acids," Proceedings of the ... proposed that the gamma-glutamyl cycle plays a role in active transport of several amino acids including glutamate, cysteine, ... However, its amino acid sequence and gene locus were unknown for many years [1-3]. Recently, Oakley et al. cloned cDNA encoding ... They found that the region consisting of 61-120 amino acids is required for the full-length GGCT to anchor in the cytoplasm and ...
ProteinsPeptidesEssential aminoProteinTransportersMetabolismUptakeExcitatoryATPaseAbstractAspartic acidBasic Amino AcidsCertain amino acidsSynthesisGlycineFattyImmune2022Neutral amino acidPantothenic acidNucleicMoleculeEliminated from one's systemMembraneHistidineConcentrationsOne's systemResiduesBCAAOrganicSubstancesMetabolicArginineSoluteMammalianGeneProtonMechanismsAnaloguesRegulationIntestinalDigestiveGlutamateCharacterizationMoleculesAbsorptionMineralsBloodstreamPathwaysVivoCellularPeptideNiacinUrineIntracellular
Proteins9
- In yeast, the majority of the amino acid transporters belong to the APC ( a mino acid- p olyamine-organo c ation) superfamily, and the proteins couple the uphill transport of amino acids to the electrochemical proton gradient. (nih.gov)
- Although high-resolution structures of yeast amino acid transporters are not available, homology models have been successfully exploited to determine and engineer the catalytic and regulatory functions of the proteins. (nih.gov)
- These simple coarse-grained analyses can be used as a general and quick method for the mechanism studies of transport proteins. (rsc.org)
- In addition to the transport of L-glutamate, a number of other naturally occurring excitatory amino acids, including L-aspartate, L-cysteine sulfinate and L-cysteate, are known substrates of these transporter proteins. (sigmaaldrich.com)
- Dietary supplements can be macronutrient (amino acids, proteins, essential fatty acids), micronutrient (vitamins and minerals that promote healthy body functions), probiotic (beneficial bacteria such as the kind found in the intestines), and herbally ( often target a specific body part, such as bones) based. (bccampus.ca)
- In Biochemistry For Dummies, you'll explore the carbons, proteins, and cellular systems that make up the biochemical processes that create and sustain life of all kinds. (biggerbooks.com)
- Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y + ), apparently as an exchange mechanism. (guidetopharmacology.org)
- As the food travels down the gut, the smaller molecules are absorbed through the lining of the intestine and into the circulatory system (for carbohydrates and proteins) or into the lymphatic system (for fats). (easynotecards.com)
- It is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, as well as in the metabolic utilization of fats and proteins and the cellular production of energy. (vitacost.com)
Peptides6
- Transport and utilization of arginine-containing peptides in alveolar macrophages. (cdc.gov)
- To investigate the transport system for small peptide uptake and the utilization of arginine-containing peptides for nitric oxide synthesis by Iypopolysaccharide (LPS)-activated alveolar macrophages. (cdc.gov)
- The uptake of these peptides by AMs may be mediated through an active peptide transport system similar to that of the pepT1 transporter. (cdc.gov)
- Our studies also showed that LPC is a potent inhibitor for the transport of small peptides in AMs. (cdc.gov)
- The relative rates of amino acid absorption from the protein hydrolysate and amino acid mixture varied markedly with concentration, demonstrating that the global hypothesis that peptides confer an advantage in amino acid absorption in vivo is too simple. (bmj.com)
- The characterization of its function has shown that (1) it transports dipeptides, tripeptides, and β-lactam antibiotics but not free amino acids or peptides with more than four amino acid residues, and (2) its driving force for uphill transport requires proton binding. (tokushima-u.ac.jp)
Essential amino1
- Moreover, the simple reduction of protein levels in feed without the correct supplementation of essential amino acids causes a reduction in feed intake and egg production, as well as altering the social behavior of the birds, resulting in cannibalism ( Peganova & Eder, 2003 Peganova, S., & Eder, K. (2003) Interactions of various supplies of isoleucine, valine, leucine and tryptophan on the performance of laying hens. (scielo.br)
Protein24
- Regulation varies from nitrogen pool sensing to control by individual amino acids and takes place at the gene (transcription), protein (posttranslational modification and allostery), and vesicle (trafficking and endocytosis) levels. (nih.gov)
- The L -arginine (Arg)/agmatine (Agm) antiporter AdiC is a vital transport protein of the arginine-dependent extreme acid resistance system of enteric bacteria. (rsc.org)
- This enzyme is essential in amino acid or protein synthesis. (aces.edu)
- The SLC6A19 gene provides instructions for making a protein called system B(0) neutral amino acid transporter 1 (B 0 AT1). (medlineplus.gov)
- This protein transports certain protein building blocks (amino acids), namely those with a neutral charge, into cells. (medlineplus.gov)
- Most of the mutations that cause Hartnup disease change single amino acids in the B 0 AT1 protein, reducing its activity. (medlineplus.gov)
- A mutation that has been identified in multiple affected families replaces the amino acid aspartic acid with the amino acid asparagine at position 173 in the protein (written as Asp173Asn or D173N). (medlineplus.gov)
- Broer S. The role of the neutral amino acid transporter B0AT1 (SLC6A19) in Hartnup disorder and protein nutrition. (medlineplus.gov)
- Certain amino acid supplements, which are often taken by bodybuilders among others, can increase the risk of consuming too much protein. (bccampus.ca)
- Most Americans receive two to three times the amount of protein required on a daily basis from their existing diets-taking amino acid supplements just adds to the excess. (bccampus.ca)
- GSH is a simple molecule, composed of 3 common amino acids: glutamate, cysteine, and glycine, which are also found in protein throughout the body. (naturalmedicinejournal.com)
- The amino acids are connected in a unique way so that GSH can be made and broken down independently of the body's protein. (naturalmedicinejournal.com)
- In protein science , Basic Amino Acids , as organic compounds , are amino acids with side chains that are positively charged at physiological pH. (wellnessadvantage.com)
- In protein science , the proteinogenic amino acid , Lysine (Lys/K) , is a classed as both a basic amino acid and a diamino amino acid , with the molecular formula (C 6 H 14 N 2 O 2 ). (wellnessadvantage.com)
- In protein science , L-Asparagine (Asn/N) , a basic neutral amino acid , is a non-essential amino acid, with a carboxamide (amino carbonyl) functional side-chain. (wellnessadvantage.com)
- Amino acid absorption from a peptide-containing protein hydrolysate and an equivalent amino acid mixture over a range of concentrations of the two--such as is thought to be found in the normal intestine after a meal--has been studied using a jejunal perfusion technique in man. (bmj.com)
- There is a highly significant correlation between amino acid absorption and the concentrations of amino acid in the perfusate, whether this contained amino acid or protein hydrolysate, suggesting that, under these experimental conditions at least, the presence of distinct amino acid and peptide transport systems is relatively unimportant. (bmj.com)
- Further studies using the yeast two-hybrid system revealed that the NS5 region (residues 320-368) immediately adjacent to the NLS contained an importin - binding site that abuts or overlaps the binding site for the NS3 protein (protease/helicase). (who.int)
- High-affinity branched-chain amino acid transport ATP-binding protein BraF, component of Branched chain amino acid uptake transporter. (lbl.gov)
- 2000. Assessing the role of ortho -substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. (cdc.gov)
- The first 29 amino acids of GHRH were changed to retain all protein characteristics. (pharmalabglobal.com)
- Ensure you eat plenty of protein food such as meat, fish, nuts, seeds, beans/lentils and eggs to support amino acids like Glutathione that protect the mitochondria. (nutritionhouse.com)
- Molecular cloning of the gene encoding rat PepT 1 has predicted a 78,710 -kilodalton protein consisting of 710 amino acid residues and processing 12 putative membrane-spanning domains. (tokushima-u.ac.jp)
- Furthermore, the molecular dynamics simulation revealed that CAP altered conformations of photosynthetic assembly protein YCF48 and SOD enzyme, and competed for functional sites of SOD, thus disturbing photosynthesis and antioxidant systems. (bvsalud.org)
Transporters8
- Advances in optical microscopy have revealed a new level of regulation of yeast amino acid transporters, which involves membrane domain partitioning. (nih.gov)
- Hence, they have been termed excitatory amino acid transporters (EAATs). (sigmaaldrich.com)
- These transporters, responsible for packaging glutamate into synaptic vesicles for neurotransmitter release, utilize a proton electrochemical gradient to drive glutamate transport into the vesicle and exhibit a very distinct pharmacology and substrate specificity from the plasma membrane localized EAATs. (sigmaaldrich.com)
- Measurement of [ 14 C]betaine uptake by HEK293 cells transiently transfected with human or rat sodium-coupled neutral amino acid transporters (SNATs), SNAT1, SNAT2 and SNAT4 revealed that only human and rat SNAT2 have betaine uptake activity. (elsevier.com)
- We describe these amino acid transporters (AATs). (lshtm.ac.uk)
- Quiñones, H , Collazo, R & Moe, OW 2004, ' The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex ', American Journal of Physiology - Renal Physiology , vol. 287, no. 1 56-1, pp. (elsevier.com)
- SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs). (guidetopharmacology.org)
- high confidence medium confidence low confidence transporter - transporters and PTS systems are shaded because predicting their specificity is particularly challenging. (lbl.gov)
Metabolism7
- Given the substantial difference in reliance on ASCT2-mediated amino acid metabolism between normal and malignant blood cells, this in vivo study suggests ASCT2 as a promising therapeutic target for the treatment of leukaemia. (nature.com)
- Extracellular free amino acids contribute to the interaction between a tumor and its microenvironment through effects on cellular metabolism and malignant behavior. (fujita-hu.ac.jp)
- Transcripts involved in metabolism, especially in carbohydrate and lipid metabolism, and cellular transport were differentially expressed. (biomedcentral.com)
- Some bacterial pathogens have been shown to substantially modify their surface components in response to the host immune system and modify their energy metabolism and transport pathways to allow efficient growth within the host. (cdc.gov)
- This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)
- Vitamin B Complex, with added Vitamin D3, supports the maintenance of normal hair, skin, bones, absorption of calcium, reduction of tiredness & fatigue, normal energy yielding metabolism, normal red blood cell production, and normal function of the immune system. (evonutrition.com)
- Vitamin B12 and folic acid contribute to normal homo-cysteine metabolism, an important factor in heart health. (evonutrition.com)
Uptake11
- Although neutral amino acids weakly inhibited the uptake of L-glutamate, there was no evidence for the heterogeneity of anionic amino acid transport system. (who.int)
- System xc(-) is composed of xCT and CD98hc subunits and functions as a plasma membrane antiporter for the uptake of extracellular cystine in exchange for intracellular glutamate. (fujita-hu.ac.jp)
- These forms follow the usual mechanisms of amino acid uptake from the digestive system. (foodforthebrain.org)
- Betaine uptake is induced by hypertonic stress in a placental trophoblast cell line, and involvement of amino acid transport system A was proposed. (elsevier.com)
- Here, we aimed to identify the subtype(s) of system A that mediates hypertonicity-induced betaine uptake. (elsevier.com)
- Betaine exclusively inhibited the uptake activity of SNAT2 among the rat system A subtypes. (elsevier.com)
- The uptake of Arg-Lys* and Beta-Ala-Lys* at concentration of 10 uM was blocked (70 - 80%) by Gly-Sar (200 uM) through competitive inhibition, but not by L-Lys, which shares a common cationic amino acid transporter with L-Arg. (cdc.gov)
- Human excitatory amino acid transporter 3 (hEAAT3) mediates glutamate uptake in neurons, intestine, and kidney. (nanion.de)
- Previous studies have indicated that NO synthesis in isolated inner medullary collecting duct cells is reduced by cationic amino acids that compete with L-arginine for cellular uptake. (elsevier.com)
- These results suggest that uptake of L-arginine by cationic amino acid transport systems in the renal medulla plays an important role in the regulation of medullary NO and MAP in rats. (elsevier.com)
- The bacterium Lactococcus lactis, which plays an important role in the dairy industry, is unable to produce the amino acid methionine and has to rely on uptake from the environment. (phys.org)
Excitatory4
- It is well established that L-glutamate acts as the major fast-acting excitatory neurotransmitter in the mammalian central nervous system. (sigmaaldrich.com)
- The subtypes EAAT1, EAAT2 and EAAT3 are the human homologs of the transporter clones initially isolated from non-human species designated as GLAST (GLutamate/ASpartate Transporter), GLT-1 (GLutamate Transporter) and EAAC1 (Excitatory Amino Acid Carrier), respectively. (sigmaaldrich.com)
- 1980. Selective depression of excitatory amino-acid induced depolarizations by magnesium ions in isolated spinal cord preparations. (cdc.gov)
- 1984. The reversal potential of excitatory amino acid action on granule cells of the rat dentate gyrus. (cdc.gov)
ATPase3
- C-terminal, AAA lid domain, Clp amino terminal domain, AAA domain (Cdc48 subfamily), ATPase family associated with various cellular activities (AAA) [Interproscan]. (ntu.edu.sg)
- It is not known if glucose transport and Na+-K+ ATPase activity are affected during the purging process. (bvsalud.org)
- Glucose transport reduction was linked to the effect of the extract on the Na+-k+-ATPase system. (bvsalud.org)
Abstract1
- abstract = "The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na+ homeostasis. (elsevier.com)
Aspartic acid1
- In our body, Asparagine (L-Asparagine) , a non-essential amino acid, with derivatives involved in diamino amino acids (dibasic amino Acid) activities is made from Aspartic Acid plus adenosine triphosphate (ATP) . (wellnessadvantage.com)
Basic Amino Acids1
- In our body, the some naturally concurring Basic Amino Acids include l-arginine , asparagine (l-asparagine) , glutamine (l-glutamine) , lysine , ornithine , and histidine . (wellnessadvantage.com)
Certain amino acids1
- As a result, affected individuals are lacking (deficient) in certain amino acids and vitamins. (medlineplus.gov)
Synthesis6
- Hence, the de novo synthesis reactions, metabolic conversions, and transport of amino acids are tightly regulated. (nih.gov)
- LPC at 1 mM, completely blocked the LPS-induced NO synthesis by AMs in either the L-Arg or the Arg peptide system. (cdc.gov)
- Methotrexate (Amethopterin) is a folic acid antagonist that binds to dihydrofolate reductase, thus interfering with the synthesis of the active cofactor tetrahydrofolic acid, which is necessary for the synthesis of thymidylate, purine nucleotides, and the amino acids serine and methionine. (medicinalplants.us)
- Fluorouracil and fluorodeoxyuridine (floxuridine) inhibit pyrimidine nucleotide biosynthesis and interfere with the synthesis and actions of nucleic acids. (medicinalplants.us)
- The first clinical evaluation of daily and attract acid molecules, aiding in the breakdown and rate-limiting step in the synthesis of the steroid hormones. (topsidepress.com)
- Albumin synthesis begins in the nucleus, where genes are transcribed into messenger ribonucleic acid (mRNA). (medscape.com)
Glycine1
- On the few occasions that probes have managed to analyze cosmic dust directly, namely the Stardust and Rosetta missions, the analysis found complex molecules, such as the simple amino acid glycine. (mpia.de)
Fatty5
- Hemp contains excellent nutritional value, providing essential nutritional components called Essential Fatty Acids (EFA) that the human body does not product naturally, and must be consumed through the diet. (vitanetonline.com)
- Additionally, weighted gene correlation network analysis confirmed the positively or negatively correlated pairs of bacterial taxa (family Veillonellaceae ) and metabolomic features (i.e., amino acids and short-chain fatty acids) responsible for FMT success. (biomedcentral.com)
- It also provide phyto-Lipids, omega 6 and omega 3 fatty acids, phyto Sterols beta sitosterol, gamma oryzanol etc. (jiji.ng)
- Algal DHA is one of the most important Omega 3 Fatty Acids present in the algal oil which is obtained from certain marine algae. (healthgeekz.net)
- Omega-3 and -6, fatty acids commonly found in fish, are often assumed to be responsible, and are commonly marketed in this fashion. (neurosciencenews.com)
Immune23
- Although using these technolo- acting on the pathogen in each microenvironment, what gies to analyze pathogens within a host is still in its infancy, bacterial factors are responsible for the host damage, and initial studies indicate that these technologies will be valu- able tools for understanding how the pathogen reacts to the how the immune system is evaded. (cdc.gov)
- Thus, pathogens must have specific mecha- clearly complex, and, in many cases, the study of these nisms for mediating colonization, avoiding the host's interactions is limited by the lack of a suitable animal immune system, and acquiring necessary nutrients. (cdc.gov)
- Under chronic conditions, variations in GSH levels occur due to nutrition, environmental exposures, and activation of the immune system. (naturalmedicinejournal.com)
- 1. Helps to boost your immune system. (jiji.ng)
- The health benefits of spirulina include strengthening the immune system, relieving inflammation, fighting chronic diseases, and prevent nutritional disorders. (jiji.ng)
- Thus, pathogens must have specific mechanisms for mediating colonization, avoiding the host's immune system, and acquiring necessary nutrients. (cdc.gov)
- We thus endeavor to understand how the pathogen adapts to the host microenvironment, what selective pressures are acting on the pathogen in each microenvironment, what bacterial factors are responsible for the host damage, and how the immune system is evaded. (cdc.gov)
- Biomarkers of organ damage or dysfunction for the renal, hepatobiliary, and immune systems. (cdc.gov)
- Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)
- Therefore, the objective of this study is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, as well as to elucidate molecular mechanisms involved in its recognition by the immune system and in cell activation. (bvsalud.org)
- Much of the current medical research has focused on either inhibiting the production or the clustering of these plaques by employing the body's immune system against them. (assistedlivingeducation.com)
- In addition, blood sugar control and the immune system may also benefit from it. (pharmalabglobal.com)
- It also improves the immune system and regulates blood sugar levels. (pharmalabglobal.com)
- It also boosts your immune system. (samreensoomro.com)
- Ginsenosides affect the central nervous, cardiovascular, and endocrine systems, improving immune function and stress responses. (murainbow.com)
- Gynostemma can boost the functioning of the immune system and is good for the digestive and cardiovascular systems. (murainbow.com)
- Protects and stimulates the skin's own defence and immune system. (lanserhof.com)
- Vitamins B6, B12 and folic acid contribute to the normal function of the immune system. (evonutrition.com)
- Read our latest blog for tips on how to give your immune system a boost. (evonutrition.com)
- Impaired lipid scrambling has been shown to weaken the immune system and evoke the autoimmune response by exposing self-antigens 11 . (nature.com)
- Though no one can deny the reality of pathogens, our zeal and focus on them should never overshadow the need to maintain a healthy, vibrant immune system. (postfalls-naturopathic.com)
- The strength of our immune system and the quality of our internal terrain truly is the basis by which disease is prevented or overcome. (postfalls-naturopathic.com)
- The immune system is composed of lymphatic vessels and organs, white blood cells, specialized cells residing in various tissues, and specialized chemical factors all of which must be supported. (postfalls-naturopathic.com)
20221
- For more information, see the paper from 2019 on GapMind for amino acid biosynthesis, the paper from 2022 on GapMind for carbon sources, or view the source code . (lbl.gov)
Neutral amino acid2
- Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. (medlineplus.gov)
- A ubiquitous sodium-dependent neutral amino acid transporter. (bvsalud.org)
Pantothenic acid3
- Apple and lentil extract additionally provide pantothenic acid and various saccharides, which make the skin barrier more resistant. (lanserhof.com)
- PABA (pantothenic acid) can contribute to normal mental performance. (evonutrition.com)
- Together with vitamins B6, B12, B3 (niacin) and pantothenic acid help contribute to normal energy release and the reduction of tiredness and fatigue. (evonutrition.com)
Nucleic1
- COLD SPRING HARBOR, NEW YORK -- In an important, comprehensive, and timely review, an expert team from the University of California Berkeley details the methodologies used in nucleic acid-based tests for detecting the presence of SARS-CoV-2, the virus that causes COVID-19. (cshlpress.org)
Molecule2
- This amino-acid-like molecule is a critical component of the complex transporting system that brings fat into the mitochondria, where it is finally burned away for good. (bodybuildingfocus.com)
- Preproalbumin is an albumin molecule with a 24 amino acid extension at the N terminus. (medscape.com)
Eliminated from one's system2
- All things considered, Biotox Gold could produce a cleansing effect to ensure that the PFTE-related toxic substances are eliminated from one's system. (4nutritionalsupplements.com)
- All points taken into consideration, Biotox Gold might create a detoxing impact so that the PFTE-related toxins are eliminated from one's system. (upruralhealth.org)
Membrane5
- The effect of cholesterol on the activity of the branched-chain amino acid transport system of Streptococcus cremoris was studied in membrane vesicles of S. cremoris fused with liposomes made of egg yolk phosphatidylcholine , soybean phosphatidylethanolamine, and various amounts of cholesterol . (bvsalud.org)
- The leucine transport activity decreased with the membrane fluidity , as determined by steady- state fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene incorporated into the fused membranes , suggesting that the membrane fluidity controls the activity of the branched-chain amino acid carrier. (bvsalud.org)
- The membrane insertion catalyzes spontaneous transport of lipid molecules between the bilayer leaflets, rapidly equilibrating the lipid composition. (nature.com)
- Furthermore, we show that our DNA-based enzyme can control the composition of human cell membranes, which opens new avenues for applications of membrane-interacting DNA systems in medicine. (nature.com)
- The amino acid extension signals insertion of preproalbumin into the membrane of the endoplasmic reticulum. (medscape.com)
Histidine2
- In a heterologous expression system, TbAAT10-1 is selective for ornithine, whereas TbAAT2-4 transports both ornithine and histidine. (lshtm.ac.uk)
- Consistent with competition for histidine, high extracellular concentrations of this amino acid phenocopied a TbAAT2-4 genetic defect. (lshtm.ac.uk)
Concentrations1
- GenFX incorporates excessive concentrations of amino acids, plant primarily based and animal based totally elements which are made in a excessive excellent FDA permitted laboratory. (bfastcharters.com)
One's system3
- All points taken into consideration, Biotox Gold may create a detoxing effect to ensure that the PFTE-related toxins are removed from one's system. (centralvalleyz.org)
- All things considered, Biotox Gold could create a purifying result to make sure that the PFTE-related toxins are removed from one's system. (capellania.org)
- All things considered, Biotox Gold may create a detoxing impact to make sure that the PFTE-related contaminants are gotten rid of from one's system. (keighleybluesclub.net)
Residues1
- A 37 amino acid sequence of NS5 (residues 369-405) was shown to contain a functional nuclear localization signal (NLS) that interacted with the cellular nuclear transport factor, importin / heterodimer. (who.int)
BCAA2
- Per serving (40 g): 100 kcal energy Creatine complex 7.7 g multi-phase creatine matrix - contains 6.8 g pure creatine buffered creatine monohydrate creatine citrate micronized creatine monohydrate 24 g carbohydrate Amino Acid complex 3 g BCAA 1 g L-citrulline 1 g L-arginine HCl VitaMineral complex 12 vitamins Who is CreaTrans recommended to? (ventrian.com)
- The presence of branched amino acids BCAA facilitate the development of muscle mass, facilitate recovery and provide energy, endurance and power. (naturveg.com)
Organic4
- Phloem is the vascular tissue in charge of transport and distribution of the organic nutrients. (erasingdavid.com)
- Molecules, including the organic molecules necessary to form amino acids, or our own DNA, can form in the interstellar medium. (mpia.de)
- Over the course of the evolution of a planetary system, organic molecules can be transported to planetary surfaces by meteorites and early comets. (mpia.de)
- Below is a breakdown of the known Minerals, Amino Acids and other Organic ingredients contained in Mountain Blood shilajit. (natureprovides.com)
Substances1
- they are the vascular tissues that transport substances throughout the plant. (erasingdavid.com)
Metabolic3
- The high creatine content increases physical performance during high-intensity training High functional amino acid content Only contains complex carbs Without added sugar With vitamins B6 and B12 to enhance metabolic processes and reduce fatigue Do you like thinking in a system? (ventrian.com)
- As a metabolic network consists of associations between genes and metabolic reactions, it can be used to study the cellular properties of the organism by integrating functional genomics data, such as gene expression and proteomics (the goal of systems biology). (biomedcentral.com)
- Together with pH determination, bicarbonate measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with acid-base imbalance in the respiratory and metabolic systems. (cdc.gov)
Arginine2
- Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced L-DOPA transport and cortical poly-A + -induced arginine and phenylalanine transport. (elsevier.com)
- Some boosters use L-Citrulline which is transported more easily into the system where it's converted to L-Arginine. (fmsguru.com)
Solute1
- Here, we report that knockout of solute carrier family 1 member 5 ( Slc1a5 /ASCT2), a transporter of neutral amino acids, especially glutamine, results in mild-to-moderate defects in bone marrow and mature blood cell development under steady-state conditions. (nature.com)
Mammalian1
- Some amino acids can protect mammalian sperm cells against oxidation during thermal stress caused by freezing/thawing. (bvsalud.org)
Gene4
- In addition to the specific set of gene functions overexpressed in early and mature oral biofilms, as detected through the short-reads dataset, the long-reads approach detected specific changes when comparing the metatranscriptome of the same individual before and after a meal, which can narrow down the list of organisms responsible for acid production and therefore potentially involved in dental caries. (biomedcentral.com)
- These studies suggest that amino acids directly stimulate the promoter activity of the PepT 1 gene. (tokushima-u.ac.jp)
- Herein, the physiological effects of chloroacetic acid (CAA) on Microcystis aeruginosa (M. aeruginosa), including acute toxicity, oxidative stress, apoptosis, production of microcystin-LR (MC-LR), and the microcystin transportation-related gene mcyH transcript abundance have been investigated. (bvsalud.org)
- Gene targeting using the Agrobacterium tumefaciens-mediated CRISPR-Cas system in rice. (cocites.com)
Proton1
- Cholesterol reduced both counterflow and proton motive force -driven leucine transport. (bvsalud.org)
Mechanisms4
- We review the mechanisms responsible for amino acid homeostasis in Saccharomyces cerevisiae and other fungi. (nih.gov)
- This has led to a further understanding of the underlying mechanisms of amino acid sensing and subsequent downregulation of transport. (nih.gov)
- Additional L-DOPA transport mechanisms exist in the renal cortex that remain to be identified. (elsevier.com)
- 36 with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. (cdc.gov)
Analogues1
- In addition, these analogues inhibit the de novo biosynthesis of purine and block the conversion of inosinic acid to adenylic acid or guanylic acid. (medicinalplants.us)
Regulation2
- The role and regulation of the tricarboxylic acid cycle in Solanum lycopersicum roots. (mpg.de)
- Our results indicate that SNAT2 transports betaine, and that tonicity-sensitive SNAT2 expression may be involved in regulation of betaine concentration in placental trophoblasts. (elsevier.com)
Intestinal3
- Doubt is thus cast upon suggestions derived from previous intestinal perfusion experiments that intact peptide transport may be nutritionally significant in man. (bmj.com)
- The effect of BaCl2 on intestinal sugar transport in the rat in vitro . (cdc.gov)
- In a separate but related system, exocrine tissues secrete their products into ducts and then to the outside of the body or to the intestinal tract. (topsidepress.com)
Digestive3
- The organs of the digestive system can be grouped into: 1. (easynotecards.com)
- its main function within the digestive system is to process the nutrients absorbed from the small intestine. (easynotecards.com)
- which components of the cheeseburger are digested in which regions of the digestive systems? (easynotecards.com)
Glutamate4
- L-glutamate was transported into mammary tissue via Na(+)-dependent system XAG- that strongly interacted with both D- and L-isomers of aspartate but only with L-isomer of glutamate. (who.int)
- Mice deficient in GLT-1 lose 80-90% of the glutamate transport capacity measured in forebrain preparations, and exhibit increased vulnerability to convulsants and to acute cortical injury, when compared with wild type animals. (sigmaaldrich.com)
- Similar to the EAATs, vesicular glutamate transport was initially described in synaptic vesicle preparations isolated from rat and bovine brain. (sigmaaldrich.com)
- The cloned VGLUTs remained elusive for a number of years before two groups simultaneously discovered that a transporter initially described as an inorganic phosphate transporter (BNPI) exhibited robust glutamate transport capacity and termed this VGLUT1. (sigmaaldrich.com)
Characterization3
- IMSEAR at SEARO: Characterization of anionic amino acid transport systems in mouse mammary gland. (who.int)
- Characterization of Short-Term Stress Applied to the Root System by Electrical Impedance Measurement in the First Leaf of Corn (Zea mays L.) and Pumpkin (Cucurbita maxima L. (scirp.org)
- Laarabi, S. (2014) Characterization of Short-Term Stress Applied to the Root System by Electrical Impedance Measurement in the First Leaf of Corn ( Zea mays L.) and Pumpkin ( Cucurbita maxima L.). American Journal of Plant Sciences , 5 , 1285-1295. (scirp.org)
Molecules1
- Through a combination of microscopic simulations and fluorescence microscopy we find the lipid transport rate catalyzed by the DNA nanostructure exceeds 10 7 molecules per second, which is three orders of magnitude higher than the rate of lipid transport catalyzed by biological enzymes. (nature.com)
Absorption3
- therefore, a concentrated excess of one amino acid obtained from a supplement may increase the probability of decreased absorption of another amino acid that uses the same transport system. (bccampus.ca)
- Comparison of the yields obtained by using nanoporous and nonporous (conventional) polarized HAp catalysts shows that both the nanoporosity and water absorption capacity of the former represent a drawback when the catalytic reaction requires auxiliary coating layers, as for example for the production of amino acids. (ibecbarcelona.eu)
- 5.) Absorption: is the passage of digested end products from the lumen of the GI tract through the mucosal cells by active or passive transport into the blood or lymph. (easynotecards.com)
Minerals3
- Xylem transports water and minerals. (erasingdavid.com)
- Plants have tissues to transport water, nutrients and minerals. (erasingdavid.com)
- What is the transport of water and minerals in plants? (erasingdavid.com)
Bloodstream4
- from there the amino acids are released into the bloodstream to be used by the body. (medlineplus.gov)
- In the kidneys, B 0 AT1 reabsorbs neutral amino acids into the bloodstream so they are not released in urine. (medlineplus.gov)
- Transport of drugs from through the use through the skin into the bloodstream. (topsidepress.com)
- Once glucose has been broken down in your small intestinale, it will be transported into your bloodstream where it will then be converted to energy. (samreensoomro.com)
Pathways1
- For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. (lbl.gov)
Vivo1
- CJC-1295 no DAC also features four altered amino chains that inhibit degradation and oxidation in production, transport, and in vivo while improving binding affinity to GHRH receptors. (pharmalabglobal.com)
Cellular3
- Abundant biochemical data support a direct causal link between low GSH, impaired defenses, and cellular susceptibility in model systems. (naturalmedicinejournal.com)
- Working at a cellular level, it is said that Mountain Blood supports every system in the body. (natureprovides.com)
- 1989. Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. (cdc.gov)
Peptide2
- L-Lys, at 10 mM, also showed a partial inhibitory effect on the Arg peptide system. (cdc.gov)
- The greatest province of these APCs is to mete out these peptide-MHC complexes to T-lymphocytes (T-cells), an impor- tant component of the adaptive untouched system. (daubnet.com)
Niacin2
- Researchers believe that many of these features are related to a deficiency of vitamin B3 (niacin) and one of its main components, the amino acid tryptophan. (medlineplus.gov)
- B vitamins including vitamin B6, B1 (thiamine), B2 (riboflavin), B3 (niacin) and B7 (biotin) contribute to normal functioning of the nervous system. (evonutrition.com)
Urine1
- This condition is characterized by increased levels of amino acids in the urine (aminoaciduria). (medlineplus.gov)
Intracellular1
- Systems' biology of inter- and intracellular metabolite transport in plants. (mpg.de)