Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Amine Oxidase (Copper-Containing): A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide.Biogenic Amines: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.Receptors, Biogenic Amine: Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.Tyramine: An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.SemicarbazidesOxidoreductases Acting on CH-NH Group Donors: Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the primary reaction. In some cases this is later hydrolyzed.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)MethylaminesMonoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.Sympathomimetics: Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.EthylaminesDihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.Phenethylamines: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.ToluidinesButylaminesPhenylhydrazines: Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)Benzylamines: Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group.Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Nitrosamines: A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.PolyaminesMonoamine Oxidase Inhibitors: A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Vesicular Biogenic Amine Transport Proteins: Integral membrane proteins of the LIPID BILAYER of SECRETORY VESICLES that catalyze transport and storage of biogenic amine NEUROTRANSMITTERS such as ACETYLCHOLINE; SEROTONIN; MELATONIN; HISTAMINE; and CATECHOLAMINES. The transporters exchange vesicular protons for cytoplasmic neurotransmitters.Diamines: Organic chemicals which have two amino groups in an aliphatic chain.Aminobiphenyl Compounds: Biphenyl compounds substituted in any position by one or more amino groups. Permitted are any substituents except fused rings.Arylamine N-Acetyltransferase: An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Kinetics: The rate dynamics in chemical or physical systems.Metaraminol: A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Benzylamine Oxidase: An aspect of monoamine oxidase, EC 1.4.3.4. Catalyzes the oxidation of benzylamine to form benzaldehyde, ammonia and hydrogen peroxide.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.IminesCadaverine: A foul-smelling diamine formed by bacterial decarboxylation of lysine.Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Biogenic Monoamines: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.Cooking: The art or practice of preparing food. It includes the preparation of special foods for diets in various diseases.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Putrescine: A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.Carbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.Aniline CompoundsBenzidines: Very toxic industrial chemicals. They are absorbed through the skin, causing lethal blood, bladder, liver, and kidney damage and are potent, broad-spectrum carcinogens in most species.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).QuinolinesSynephrine: Sympathetic alpha-adrenergic agonist with actions like PHENYLEPHRINE. It is used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Normetanephrine: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.PropylaminesImipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.Catecholamines: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.Histamine: An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.DimethylaminesSubstrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Deamination: The removal of an amino group (NH2) from a chemical compound.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).PQQ Cofactor: A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Aldehydes: Organic compounds containing a carbonyl group in the form -CHO.Epinephrine: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.QuinoxalinesTranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)Ethylenediamines

Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart. (1/2065)

1 N-2-Chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP 4) 50 mg/kg intraperitoneally, produced a long-term decrease in the capacity of brain homogenates to accumulate noradrenaline with significant effect 8 months after the injection. It had no effect on the noradrenaline uptake in homogenates from the striatum (dopamine neurones) and on the uptake of 5-hydroxytryptamine (5-HT) in various brain regions. 2 In vitro DSP 4 inhibited the noradrenaline uptake in a cortical homogenate with an IC50 value of 2 muM but was more than ten times less active on the dopamine uptake in a striatal homogenate and the 5-HT uptake in a cortical homogenate. 3 DSP 4 (50 mg/kg i.p.) inhibited the uptake of noradrenaline in the rat heart atrium in vitro but this action was terminated within 2 weeks. 4 DSP 4 (50 mg/kg i.p.) cuased a decrease in the dopamine-beta-hydroxylase (DBH) activity in the rat brain and heart. The onset of this effect was slow; in heart a lag period of 2-4 days was noted. In brain the DBH-activity in cerebral cortex was much more decreased than that in hypothalamus which was only slightly affected. A significant effect was still found 8 months after the injection. The noradrenaline concentration in the brain was greatly decreased for at least two weeks, whereas noradrenaline in heart was only temporarily reduced. 5 The long-term effects of DSP 4 on the noradrenaline accumulation, the DBH activity and noradrenaline concentration in the rat brain were antagonized by desipramine (10 mg/kg i.p.). 6 It is suggested that DSP 4 primarily attacks the membranal noradrenaline uptake sites forming a covalent bond and that the nerve terminals, as a result of this binding, degenerate.  (+info)

Analysis of gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring. (2/2065)

A simple method for the determination of gabapentin (Neurontin) is described. The method uses solid-phase extraction by disk column and derivatization followed by gas chromatographic-mass spectrometric analysis. The single-step derivatization with MTBSTFA produces a t-BDMS derivative of both the carboxylic and amine moieties of the molecule. Each step of the procedure was optimized to assure reliable performance of the method. The assay limit of detection was 0.1 microg/mL with a linear range from 1.0 to 35 microg/mL. Within-run (n = 3) and between-run (n = 40) coefficients of variation were less than 8.2 and 15.9%, respectively. The method has proven reliable in routine production for more than a year, producing clean chromatography with unique ion fragments, consistent ion mass ratios, and no interferences. Statistical analysis of the gabapentin concentrations measured in 1020 random specimens over a 2-month period showed a mean concentration of 6.07 microg/mL with a standard deviation of 5.28.  (+info)

Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. (3/2065)

Repetitive ectopic discharges from injured afferent nerves play an important role in initiation and maintenance of neuropathic pain. Gabapentin is effective for treatment of neuropathic pain but the sites and mechanisms of its antinociceptive actions remain uncertain. In the present study, we tested a hypothesis that therapeutic doses of gabapentin suppress ectopic afferent discharge activity generated from injured peripheral nerves. Mechanical allodynia, induced by partial ligation of the sciatic nerve in rats, was determined by application of von Frey filaments to the hindpaw. Single-unit afferent nerve activity was recorded proximal to the ligated sciatic nerve site. Intravenous gabapentin, in a range of 30 to 90 mg/kg, significantly attenuated allodynia in nerve-injured rats. Furthermore, gabapentin, in the same therapeutic dose range, dose-dependently inhibited the ectopic discharge activity of 15 injured sciatic afferent nerve fibers through an action on impulse generation. However, the conduction velocity and responses of 12 normal afferent fibers to mechanical stimulation were not affected by gabapentin. Therefore, this study provides electrophysiological evidence that gabapentin is capable of suppressing the ectopic discharge activity from injured peripheral nerves. This action may contribute, at least in part, to the antiallodynic effect of gabapentin on neuropathic pain.  (+info)

Removal of non-specific serum inhibitors of haemagglutination of rubella virus by treatment with dodecylamine-gel. (4/2065)

The suitability of using dodecylamine-gel for removing the serum non-antibody-like inhibitors of haemagglutination by rubella was studied. Compared with kaolin and MnCl2/heparin treatment this new procedure appears to have a higher specificity since it removes the non-antibody-like inhibitors from serum without affecting the immunoglobulin level significantly. The potential application of this procedure in routine serological analysis for rubella virus infection is discussed.  (+info)

N-acetyltransferase 1 genetic polymorphism, cigarette smoking, well-done meat intake, and breast cancer risk. (5/2065)

N-Acetyltransferase 1 (NAT1), encoded by the polymorphic NAT1 gene, has been shown to be one of the major enzymes in human breast tissue that activates aromatic and heterocyclic amines. Humans are mainly exposed to these carcinogens through cigarette smoking and consumption of well-done meat. To test the hypothesis that variations in the NAT1 gene are related to breast cancer risk, particularly among women who smoke or consume high levels of well-done meat, a nested case-control study was conducted in a prospective cohort study of 41,837 postmenopausal Iowa women. Information on cigarette smoking and other breast cancer risk factors was obtained at the baseline survey conducted in 1986. DNA samples and information on the consumption of well-done meat were obtained, in the case-control study, from breast cancer cases diagnosed from 1992 to 1994 and a random sample of cancer-free cohort members. Genomic DNA samples obtained from 154 cases and 330 controls were assayed for 11 NAT1 alleles (NAT1*3, *4, *5, *10, *11, *14, *15, *16, *17, *19, and *22). The NAT1*4 allele was the predominant allele observed in this study population, accounting for 73.2% (72.4% in cases versus 73.8% in controls) of the total alleles analyzed. Compared to controls, breast cancer cases had a slightly higher frequency of the NAT1*10 allele (18.8% in cases versus 17.3% in controls) and a substantially higher frequency of the NAT1*11 allele (3.6% versus 1.2%). In multivariate analyses, we found a 30% [95% confidence interval (CI) = 0.8-1.9] elevated risk of breast cancer associated with the NAT1*10 allele and a nearly 4-fold (95% CI = 1.5-10.5) elevated risk associated with the NAT1*11 allele. The positive association of breast cancer with the NAT1*11 allele was more evident among smokers [odds ratio (OR) = 13.2, 95% CI = 1.5-116.0] and those who consumed a high level of red meat (OR = 6.1, 95% CI = 1.1-33.2) or consistently consumed their red meat well done (OR = 5.6, 95% CI = 0.5-62.7). The association of the NAT1*10 allele with breast cancer was mainly confined to former smokers (OR = 3.3, 95% CI = 1.2-9.5). These findings are consistent with a role for the NAT1 gene in the etiology of human breast cancer.  (+info)

An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. (6/2065)

We performed intracellular recordings from a rat corticostriatal slice preparation in order to compare the electrophysiological effects of the classical antiepileptic drug (AED) phenytoin (PHT) and the new AEDs lamotrigine (LTG) and gabapentin (GBP) on striatal neurons. PHT, LTG and GBP affected neither the resting membrane potential nor the input resistance/membrane conductance of the recorded cells. In contrast, these agents depressed in a dose-dependent and reversible manner the current-evoked repetitive firing discharge. These AEDs also reduced the amplitude of glutamatergic excitatory postsynaptic potentials (EPSPs) evoked by cortical stimulation. However, substantial pharmacological differences between these drugs were found. PHT was the most effective and potent agent in reducing sustained repetitive firing of action potentials, whereas LTG and GBP preferentially inhibited corticostriatal excitatory transmission. Concentrations of LTG and GBP effective in reducing EPSPs, in fact, produced only a slight inhibition of the firing activity of these cells. LTG, but not PHT and GBP, depressed cortically-evoked EPSPs increasing paired-pulse facilitation (PPF) of synaptic transmission, suggesting that a presynaptic site of action was implicated in the effect of this drug. Accordingly, PHT and GBP, but not LTG reduced the membrane depolarizations induced by exogenously-applied glutamate, suggesting that these drugs preferentially reduce postsynaptic sensitivity to glutamate released from corticostriatal terminals. These data indicate that in the striatum PHT, LTG and GBP decrease neuronal excitability by modulating multiple sites of action. The preferential modulation of excitatory synaptic transmission may represent the cellular substrate for the therapeutic effects of new AEDs whose use may be potentially extended to the therapy of neurodegenerative diseases involving the basal ganglia.  (+info)

Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat. (7/2065)

Cooking meat and fish under normal conditions produces heterocyclic amine mutagens, several of which have been shown to induce colon tumors in experimental animals. In our search for natural dietary components that might protect against these mutagens, it was found that green tea and black tea inhibit the formation of heterocyclic amine-induced colonic aberrant crypt foci (ACF) in the rat. Since ACF are considered to be putative preneoplastic lesions, we examined the inhibitory mechanisms of tea against the heterocyclic amines. In the initial studies using the Salmonella mutagenicity assay, green tea and black tea inhibited according to the concentration of tea leaves during brewing and the time of brewing; a 2-3-min brew of 5% green tea (w/v) was sufficient for >90% antimutagenic activity. N-hydroxylated heterocyclic amines, which are direct-acting mutagens in Salmonella, were inhibited by complete tea beverage and by individual components of tea, such as epigallocatechin-3-gallate (EGCG). Inhibition did not involve enhanced mutagen degradation, and EGCG and other catechins complexed only weakly with the mutagens, suggesting electrophile scavenging as an alternative mechanism. Enzymes that contribute to the metabolic activation of heterocyclic amines, namely microsomal NADPH-cytochrome P450 reductase and N, O-acetyltransferase, were inhibited by tea in vitro. Studies in vivo established that tea also induces cytochromes P450 and Phase II enzymes in a manner consistent with the rapid metabolism and excretion of heterocyclic amines. Collectively, the results indicate that tea possesses anticarcinogenic activity in the colon, and this most likely involves multiple inhibitory mechanisms.  (+info)

Phospholipid-assisted refolding of an integral membrane protein. Minimum structural features for phosphatidylethanolamine to act as a molecular chaperone. (8/2065)

Escherichia coli-derived phosphatidylethanolamine (PE) or PE with fully saturated fatty acids was able to correct in vitro a defect in folding in the lipid-dependent epitope 4B1 of lactose permease (LacY) resulting from in vivo assembly in the absence of PE. PE plasmalogen, PE with two unsaturated fatty acids, and lyso-PE, which all do not favor bilayer organization, did not support proper refolding. Proper refolding occurred when these latter lipids were mixed with a bilayer-forming lipid (phosphatidylglycerol), which alone could not support refolding. L-Phosphatidylserine (PS; natural diastereomer) did support proper refolding. PE derivatives of increasing degrees of methylation were progressively less effective in supporting refolding, with phosphatidylcholine being completely ineffective. Therefore, the properties of nonmethylated aminophospholipids capable of organization into a bilayer configuration are essential for the recovery of the native state of epitope 4B1 after misassembly in vivo in the absence of PE. Neither D-PS (sn-glycero-1-phosphate backbone) nor P-D-S (D-serine in the head group) is competent in supporting proper refolding unless used in binary mixtures with phosphatidylglycerol. The detailed characterization of phospholipid-assisted refolding reported here further supports a specific rather than nonspecific role for PE in structural maturation of lactose permease in vivo (Bogdanov, M., and Dowhan, W. (1998) EMBO J. 17, 5255-5264).  (+info)

Disclosed is an aromatic amine derivative represented by the general formula (1) or (2) below and having a diphenylamino group wherein a cycloalkyl group is bonded to a benzene ring. Also disclosed is an organic electroluminescent device wherein an organic thin film composed of one or more layers including at least a light-emitting layer is interposed between a cathode and an anode, and at least one layer of the organic thin film contains the aromatic amine derivative by itself or as a component of a mixture. This organic electroluminescent device has long life and high luminous efficiency, and is capable of emitting blue light with high color purity. The aromatic amine derivative enables to realize such an organic electroluminescent device. (1) (2) (In the general formula (1), A,sub,1,/sub,-A,sub,4,/sub, respectively represent a hydrogen atom or the like, and a-d respectively represent an integer of 0-5. In this connection, at least one of a-d represents an integer of not less than 1, and in ...
TY - JOUR. T1 - Simultaneous aqueous chlorination of amine-containing pharmaceuticals. AU - Liu, Yu-Jung. AU - Liu, Hui-Sz. AU - Hu, Ching-Yao. AU - Lo, Shang-Lien. PY - 2019. Y1 - 2019. N2 - Amine-containing pharmaceuticals such as acetaminophen, diclofenac, and sulfamethoxazole are the most often detected pharmaceuticals in wastewater and other aquatic environments. Amine-containing pharmaceuticals can be effectively removed by chlorination. These drugs, however, may coexist in wastewater. Thus, they may compete with each other, and their chlorinated products may react with each other to form new products. In this study, competitive effects of the above three amine-containing pharmaceuticals by chlorination and their products were investigated. The priority of chlorination of these compounds was dependent upon the pH of the solution, due to the dissociation of the compounds and hypochlorite. It followed the order of sulfamethoxazole , diclofenac , acetaminophen in an acidic condition, the ...
Abstract. Multivalent metal salts, such as ferric chloride and sulfate, are active and versatile catalysts for the amidation of aliphatic fatty acids with long-chain aliphatic amines.. ...
Modified aliphatic amine Hardener KB-NF,Particularly suitable for winter and spring carbon fiber plastic, steel sticky toughness curing agent_OKCHEM
N,N-Substituted amine derivatives were designed by utilizing a bioisosterism strategy. Consequently, twenty-two compounds were synthesized and evaluated for their inhibitory activity against CETP. Structure-activity relationship (SAR) studies indicate that hydrophilic groups at the 2-position of the tetrazole and 3,5-bistrifluoromethyl groups on the benzene ring provide important contributions to the potency. Among these compounds, compound 17 exhibited excellent CETP inhibitory activity (IC50 = 0.38 ± 0.08 μM) in vitro. Furthermore, compound 17 was selected for an in vitro metabolic stability study.
TABLE-US-00002 TABLE 2 Insecticidal (Heteroarylalkyl)alkane Thio and Oxo Amine Derivatives Compound Characterization Melting Point (° C.) of Solids Molecular Formula Or Physical State 1-1 C33H36Cl2N6O4S2 OIL 1-2 C23H24Cl2N6O2S2 OIL 1-3 C27H40Cl2N6O2S2 OIL 1-4 C25H36Cl2N6O2S2 OIL 1-5 C25H32Cl2N6O2S2 OIL 1-6 C19H20Cl2N6O2S4 OIL 1-7 C21H32Cl2N6O2S4 OIL 1-8 C21H22Cl2N8O2S2 OIL 1-9 C17H18Cl2N4O2S2 GUM 1-10 C18H21ClN4O3S2 OIL 1-11 C11H15ClN4O2S2 OIL 1-12 C13H15ClN4O2S2 OIL 1-13 C15H23ClN4O2S2 OIL 1-14 C14H21ClN4O2S2 OIL 1-15 C14H19ClN4O2S2 OIL 1-16 C11H13ClN4O2S3 OIL 1-17 C12H19ClN4O2S3 OIL 1-18 C12H14ClN5O2S2 OIL 1-19 C14H17ClN4O2S2 OIL 1-20 C25H28Cl2N6O2S2 OIL 1-21 C14H21ClN4O3S OIL 2-1 C32H31Cl4N5O2S2 OIL 2-2 C24H25Cl2N5O2S2 OIL 2-3 C34H37Cl2N5O4S2 OIL 2-4 C26H37Cl2N5O2S2 OIL 2-5 C28H41Cl2N5O2S2 OIL 2-6 C26H33Cl2N5O2S2 OIL 2-7 C20H21Cl2N5O2S4 OIL 2-8 C22H33Cl2N5O2S4 OIL 2-9 C22H23Cl2N7O2S2 OIL 2-10 C24H29Cl2N5O2S2 OIL 2-11 C12H16ClN3O2S2 OIL 2-12 C18H19Cl2N3O2S2 OIL 2-13 C14H16ClN3O2S2 OIL 2-14 ...
Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group that can be reacted with an amine-containing material, particularly a primary aliphatic amine, to form a connector group between the substrate and the amine-containing material. The invention also provides articles and methods for immobilizing amine-containing materials to a substrate.
Business Standard News: Corporate Action: Alkyl Amines Chemicals (ALKYLAMINE) - Business Standard News and more from Business Standard News
Alpha-oligopeptide / Glutamine or derivatives / N-acyl-alpha amino acid or derivatives / Alpha-amino acid amide / Cysteine or derivatives / Alpha-amino acid / D-alpha-amino acid / N-substituted-alpha-amino acid / Alpha-amino acid or derivatives / Fatty acylFatty acid / Dicarboxylic acid or derivatives / N-acyl-amine / Fatty amide / Organic disulfide / Dialkyldisulfide / Carboxamide group / Secondary carboxylic acid amide / Amino acid or derivatives / Amino acid / Sulfenyl compound / Carboxylic acid / Secondary aliphatic amine / Secondary amine / Primary amine / Organopnictogen compound / Organic oxygen compound / Organic nitrogen compound / Carbonyl group / Hydrocarbon derivative / Amine / Organic oxide / Primary aliphatic amine / Organosulfur compound / Organooxygen compound / Organonitrogen compound / Aliphatic acyclic compound ...
Alkyl Amines Chemicals Limited operates in the Chemicals & Allied Products sector. Alkyl Amines Chemicals Limited is engaged in the business of specialty chemicals. The Company is involved in the manufacture of organic and inorganic chemical compounds. Its products include Methylamine, Ethylamine, Isopropylamine, Propylamine, Butylamine, Ethylhexylamine, Cyclohexylamine, Diallylamine, Dimethylpropylamine, Di-Methylbutylamine, Mono-n-Butylamine, Diisobutylamine, Hydroxylnovaldiamine, Imino Bis Propylamine, Methylamine Hydrochloride and Dimethylimidazolidone. It supplies amines and amine-based chemicals to the pharmaceutical, agrochemical, rubber chemical and water treatment industries. It has approximately two manufacturing sites with over nine production plants and related utilities at Patalganga and Kurkumbh in Maharashtra. The Company caters to both domestic and international markets. It has various facilities to manufacture a range of specialty chemicals with its inhouse developed technologies.
Easily label your own tag ligands & other small molecules. Mix-n-Stain™ CF® dye small ligand labeling kits are designed for rapid labeling of small (MW ~ 150 - 5,000) and relatively high affinity biological ligands (or substrates). Labeling takes about 30 minutes, without a final purification step. The ligands to be labeled must contain an aliphatic amine group that is not required for biological activity of the ligand. The amine group will form a covalent linkage with the reactive CF® dye provided in the kit. For example, suitable ligands or substrates include SNAP-tag®, CLIP-tag™ and HaloTag® ligands with an aliphatic amine. Many other small ligands are also possible candidates if they meet the criteria described above.. Simply mix your small molecule ligand with the reaction buffer and the optimally formulated dye provided, and incubate for 30 minutes, followed by a brief 5 minute quenching step. No reactive Mix-n-Stain™ dye is available at the end of labeling; therefore the ...
0018]As for stabilizers, for instance there are amine compounds such as primary amine, secondary amine, and tertiary amine; ammonium carbamate, ammonium carbonate, and ammonium bicarbonate based compounds; phosphorus compounds such as phosphine, phosphite, and phosphate; sulfur compounds including thiol and sulfide. They consist of these compounds or mixture of more than at least one of them. As the concrete amine compounds, for example, they are selected from the group consisting of methyl amine, ethyl amine, n-propyl amine, isopropyl amine, n-butyl amine, isobutyl amine, isoamyl amine, n-hexyl amine, 2-ethylhexyl amine, n-heptyl amine, n-octyl amine, isooctyl amine, nonyl amine, decyl amine, dodecyl amine, hexadecyl amine, octadecyl amine, docodecyl amine, cyclopropyl amine, cyclopentyl amine, cyclohexyl amine, allyl amine, hydroxy amine, ammonium hydroxide, methoxy amine, 2-ethanolamine, methoxyethyl amine, 2-hydroxypropyl amine, 2-hydroxy-2-methylpropyl amine, methoxypropyl amine, cyanoethyl ...
Heterocyclic amines are a group of chemical compounds, many of which can be formed during cooking. They are found in meats that are cooked to the "well done" stage, in pan drippings and in meat surfaces that show a brown or black crust. Epidemiological studies show associations between intakes of heterocyclic amines and cancers of the colon, rectum, breast, prostate, pancreas, lung, stomach/esophagus and animal feeding experiments support a causal relationship. The U.S. Department of Health and Human Services Public Health Service labeled several heterocyclic amines as likely carcinogens in its 13th Report on Carcinogens. Changes in cooking techniques reduce the level of heterocyclic amines. More than 20 compounds fall into the category of heterocyclic amines, often abbreviated HCAs[1]. Table 1 shows the chemical name and abbreviation of those most commonly studied. All four of these compounds are included in the 13th Report on Carcinogens. The compounds found in food are formed when creatine (a ...
Decades of drug-discovery research have shown that drug molecules that need to cross the cell membrane exhibit a relatively narrow range of physicochemical properties, e.g., molecular mass, hydrophobicity and polarity. A recent survey of a dataset of human approved drugs has found that 27% of these are aliphatic amines and 20% are carboxylic acids [1,2]. In an aqueous environment at neutral pH, aliphatic amines have a propensity to be protonated and carry an electric charge of +1e.. ...
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Global (North America, Europe and Asia-Pacific, South America, Middle East and Africa) Copper Paste Market 2018 Forecast to 2023. COPPER PASTE is a high temperature anti-seize lubricant. A soft, copper-coloured paste, based on micronized copper powder and synergistic anti-oxidant, anti-corrosion and anti-wear additives suspended in premium grade stable oil. It is an effective anti-seize formulation, preventing metal-to-metal contact, seizing, galling, and fretting corrosion. Scope of the Report: This report focuses on .... February 2018 , $4880 ,View Details>> ...
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
Wherever you look, a part of us is there From coatings to transportation and energy to construction, weve been enabling progress through Responsible Chemistry for over half a century ...
Amine salts, amic acids, amic acid amine salts bis-amides and imides of oil-soluble thio-bis-(C12-50 alkyl lactone acid), e.g. a secondary hydrogenated tallow amide of dithio-bis-(C16 -C24 alkyl lactone carboxylic acid), are useful in combination with a coadditive hydrocarbon such as an amorphous hydrocarbon or a hydrogenated polybutadiene in improving the cold flow properties of distillate hydrocarbon oils.
Three different cyclic amine dyes, 9-(2-chlorophenyl)-9H-carbazole (CPCz; C18H12ClN), 10-(2-chlorophenyl)-10H-phenoxazine (CPPo; C18H12ClNO), and 10-(2-chlorophenyl)-10H-phenothiazine (CPPt; C18H12ClNS), were synthesized to systematically investigate their optical properties and electronic band structures with molecular microstructure. By the insertion of oxygen or sulfur atom into carbazole moiety, the absorption and photoluminescence (PL) spectra showed bathochromic shift, and the Stokes shift was increased. Ionization potential of CPCz was measured as 5.75eV, on the other hand, CPPo and CPPt showed their ionization potentials of 5.37 and 5.39eV, respectively. The minute difference in chemical structure such as insertion of oxygen or sulfur atom caused huge change of optical property and electronic band structure. ...
Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
Solvation significantly affects the basicity of amines. N-H groups strongly interact with water, especially in ammonium ions. Consequently, the basicity of ammonia is enhanced by 1011 by solvation. The intrinsic basicity of amines, i.e. the situation where solvation is unimportant, has been evaluated in the gas phase. In the gas phase, amines exhibit the basicities predicted from the electron-releasing effects of the organic substituents. Thus tertiary amines are more basic than secondary amines, which are more basic than primary amines, and finally ammonia is least basic. The order of pKbs (basicities in water) does not follow this order. Similarly aniline is more basic than ammonia in the gas phase, but ten thousand times less so in aqueous solution.[11]. In aprotic polar solvents such as DMSO, DMF, and acetonitrile the energy of solvation is not as high as in protic polar solvents like water and methanol. For this reason, the basicity of amines in these aprotic solvents is almost solely ...
The far infrared spectra of a number of aliphatic amines have been recorded as dilute solutions in cyclohexane. A characteristic band with center at 225 ± 10 cm,sup,−1,/sup, is present in the spectra of aliphatic primary amines with a primary α-carbon atom. On the basis of the deuterium shift this band is assigned to the amino torsion. The effects of branching at the α-carbon, coupling of methyl and amino torsions, and intramolecular association on the frequencies of NH,sub,2,/sub, torsions are discussed ...
US EPA PC Code ); 039301 (US EPA PC Code Text ); 2-Hydroxypropanoic acid, compd. with 1-dodecanamine (1:1); 2-Hydroxypropanoic acid, compd. with 1-dodecanamine (1:1); 2002 (CA DPR Chem Code) ); 7491-20-5 (CAS number); 7491205; 7491205 (CAS number without hyphens); Dodecylamine lactate; DODECYLAMINE LACTATE (CA DPR Chem Code Text ); Dodecylaminelactate; Lactic acid, compd. with dodecylamine (1:1); Lactic acid, compd. with dodecylamine (1:1 ...
|b|Amines|/b| |br/|Long chain aliphatic amines are widely used to combat corrosion. Octadecylamine is used to protect condensate lines by forming a protective film. Amines that are volatile in steam are used to neutralise carbon dioxide in boiler condensate. They are also used to increase the pH value of feedwater or boiler water in order to prevent corrosion.
A dispersant derivatized from a functionalized hydrocarbon and a polyamine having one primary amine and 1-10, preferably 3-8 secondary or tertiary amines; preferably where said functionalized hydrocarbon is a Koch-derived hydrocarbon.
No data available for the determination of toxicokinetics, metabolism and distribution. In general, lower primary aliphatic amines are metabolized to the corresponding carboxylic acid and urea. Assessment of Toxicokinetic Behaviour 3-(Dimethylamino)propylamine (Cas-No. 109-55-7) is a colorless liquid with a molecular weight of 102.2 g/mol and a vapor pressure of 5.9 hPa (20°C). It is miscible in water and the log Po/w is -0.352. Evidence for systemic availability of 3-(Dimethylamino)propylamine comes from acute (oral, dermal, inhalation) and subacute toxicity. The LD50 for oral acute toxicity in rats was calculated as ca. 1600 mg/kg body weight (BASF, 1958). Main clinical signs observed were drowsiness and staggered gait. At necropsy, decomposition of abdominal cavity and haemorrhagic stomachs were observed. In three further studies the test substance caused likewise moderate toxicity after a single ingestion LD50 = 1037 mg/kg BW (Hoechst, 1979), LD50 = 922 mg/kg BW (Bayer, 1979), LD50=1870 ...
a class of organic compounds of nitrogen that may be considered as derived from ammonia (NH3) by replacing one or more of the hydrogen atoms by organic radicals, such as CH3 or C6H5, as in methylamine and aniline. The former is a gas at ordinary temperature and pressure, but other amines are liquids or solids. All amines are basic in nature and usually combine readily with hydrochloric or other strong acids to form salts ...
Aradur®Aradur® curing agents are supplied in liquid or solid form and can be used in conjunction with Araldite® epoxy resins to achieve a broad range of thermal, mechanical and electrical properties. This complete line of high performance curing agents includes reactive polyamides, polyamido amines, aliphatic amines, cycloaliphatic amines, aromatic amines, anhydrides and novolacs ...
This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
Amine dehydrogenase (AmDH) possesses tremendous potential for the synthesis of chiral amines because AmDH catalyzes the asymmetric reductive amination of ketone with high enatioselectivity. Although a reductive application of AmDH is favored in practice, the oxidative route is interesting as well for the preparation of chiral amines. Here, the kinetic resolution of racemic amines using AmDH was first extensively studied, and the AmDH reaction was combined with an NADH oxidase (Nox) to regenerate NAD+ and to drive the reaction forward. When the kinetic resolution was carried out with 10 mM rac-2-aminoheptane and 5 mM rac-α-methylbenzylamine (α-MBA) using purified enzymes, the enantiomeric excess (ee) values were less than 26% due to the product inhibition of AmDH by ketone and the inhibition of Nox by the substrate amine. The use of a whole-cell biocatalyst co-expressing AmDH and Nox apparently reduces the substrate and product inhibition, and/or it increases the stability of the enzymes. Fifty
A primary aliphatic amine with excellent resistance to oxidation, fluidity, low viscosity over a wide range of temperature, outstanding color stability, and high solubility in petroleum hydrocarbons.
C08G65/2624-Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups ...
Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ...
Since the publication of Guggenheims book "Die Biogenen Amine" in 1951, knowledge about the endogenous amines has steadily been increasing. Research on the cellular a subcellular distribution of the amines, as well as the mechanisms involved in the release and uptake of these amines has been proceeding apace (Davis et a!., 1978). Certain of these amines in addition to their function as neurotransmitters also serve the function of hormones. Abnormalities in the synthesis, release or metabolism of these amines are associated with a number of diseases including pheochromocytoma, neuroblastoma, schizophrenia, depressive disorders and Parkinsons disease (Keller et al., 1976). A prerequisite to the determination of the roles which these amines play in the pathogenesis of diseases is a sensitive method for the determination of their concentration in biological fluids and tissues. Various methods including fluorescence, gaschromatography and mass spectrometry have been developed for amine ...
In this study, the potential of synchronous front-face fluorescence spectroscopy (SFS) coupled with chemometrics was investigated for the determination of heterocyclic aromatic amines (HAA) in coo ...
In this paper the kinetics of the reaction between sodium ethyl xanthogenacetate (NaEtXAc) and six amines was investigated. In order to determine the wavelength for following the reaction, the influence of the structures of reactants on the absorption (at 280 nm) was investigated. The values of rate constants for selected amines, at different temperatures were determined. It was confirmed that the reactions investigated are of the second-order. On the basis of the reaction rate constants and at the different temperatures, several thermodynamic parameters were calculated such as the energy of activation, the frequency factor, the activation entropy, Gibbs free-energy of the activation and the activation enthalpy. By evaluating the obtained results some assumptions that refer to the reaction mechanisms of nucleophilic attack of amine on the thiocarbonyl carbon, as well as forming of an activated complex as a critical step, were made ...
You may also wish to search for items by Cibulka. 31 matching references were found. Cibulka, I.; Hnedkovsky, L.; Takagi, T., P-«rho»-T Data of Liquids: Summarization and Evaluation. 3. Ethers, Ketones Aldehydes, Carboxylic Acids, and Esters, J. Chem. Eng. Data, 1997, 42, 2-26. [all data] Kasparek, M.; Cibulka, I.; Hnedkovsky, L., Excess molar volumes of binary mixtures of some aliphatic amines with selected members of homologous series of n-alkanes at T = 298.15 K, J. Chem. Thermodyn., 1996, 28, 595-601. [all data] Cibulka, I.; Hnedkovsky, L., Liquid Densities at Elevated Pressur of n-Alkanes from C5 to C16. A Critical Evaluation of Experimental Data, J. Chem. Eng. Data, 1996, 41, 657-58. [all data] Skranc, W.; Cibulka, I.; Hnedkovsky, L., Excess Volumes of 1,4-Dioxane + Ethane-1,2-diol at 298.15 K, J. Chem. Eng. Data, 1995, 40, 974-5. [all data] Izak, P.; Cibulka, I.; Heintz, A., Partial molar volumes of air-component gases in several liquid n-alkanes and 1-alkanols at 313.15 K, Fluid Phase ...
By combining leucine (Leu) and tetraphenylethene (TPE), a pH-sensitive aggregation induced emission (AIE) probe TPE-Leu was developed. The aliphatic amine in TPE-Leu was more easily protonated under acidic conditions, which made TPE-Leu more water soluble. Therefore, the protonated AIE probe showed weak fluorescenc
Although photoluminescence of tertiary aliphatic amines has been extensively studied, the usage of this fundamental chromophore as a fluorescent probe for various applications has unfortunately not been realized because their uncommon fluorescence is easily quenched, and strong fluorescence has been observed only in vapor phase. The objective of this study is how to retain the strong fluorescence ...
Chiral amines are frequent in today´s top selling pharmaceuticals. Classical organic synthesis of pharmaceuticals is often work intensive involving many synthesis steps, the use of protection group chemistry, heavy metal catalysts and chiral crystallization techniques. In recent years biocatalysts have proven their outstanding ability to synthesize chiral compounds. In this work the possibility of employing biocatalysts as alternative catalysts for API (active pharmaceutical ingredient) synthesis was explored. Three compounds currently on the market were selected as viable case studies: Cinacalcet (a hyperparathyroidism drug), Vyvanse (an ADHD-drug) and Sertraline (an antidepressant). Two enzyme classes were investigated to directly provide the chiral amines - transaminases and imine reductases. Ketoreductases were also investigated to provide the chiral amine via the chiral alcohol. Laccases and hydrolases were employed to complete the synthesis pathways to the final API. In the case of ...
3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140), when injected into rats at i.p. doses of 1 to 10 mg/kg, prevented the lowering of brain serotonin by 4-chloroamphetamine. The duration of 110140 action was very long, significant antagonism of 4-chloroamphetamine action being apparent still at 48 hours after a single dose of 10 mg/kg of 110140. The N,N-dimethyl tertiary amine derivative was as effective as 110140 itself in antagonizing serotonin depletion by 4-chloroamphetamine, but other structurally related compounds had less activity or were inactive. Likewise, six tricyclic antidepressant drugs injected at 10 mg/kg i.p. did not antagonize the action of 4-chloroamphetamine. When injected into rats whose brain serotonin levels had already been depleted by 3-hour pretreatment with 4-chloroamphetamine, 110140 terminated the action of 4-chloroamphetamine and permitted serotonin levels to return to normal. Lilly 110140 did not antagonize the depletion of brain serotonin or ...
Tedford CE, Schott MJ, Flynn JR, Cannon JG, Long JP. A-4, a bis tertiary amine derivative of hemicholinium-3 produces in vivo reduction of acetylcholine in rat brain regions. J Pharmacol Exp Ther. 1987;240(2):476-85. Abstract ...
The long term goal of our research program is to elucidate the molecular mechanisms of DNA adduct-induced chemical carcinogenesis. Aromatic amines are well-know...
When we talk about chain isomers we mean isomers with different carbon skeleton.. If the carbon skeleton is changing as well as the functional group we report it as functional group isomerism.. For the given compound in your question, primary, secondary and tertiary amines will show functional group isomerism as they are forming different types of amines itself.. ...
Amines Market Analysis By Product (Ethanolamines, Fatty Amines, Alkylamines), Application (Crop Protection, Surfactants, Water ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Alkyl Amines Chemicals PBT & PAT: PBT stands for Profit Before Tax, and PAT stands for Profit After Tax. The graph visually shows how the net profit of the company stand reduced due to the impact of Tax.
Exposure to aromatic amines is considered a major risk factor for the development of bladder cancer. In this study, we have analysed the pattern of point mutations in several tumour genes in 21 cases of bladder cancer arising among western European workers exposed to aromatic amines in an attempt to determine whether this exposure may be...
Amines are derived from the amino acid tyrosine and are secreted from the thyroid and the adrenal medulla. Solubility of the various hormone classes varies. Amine hormones (notably epinephrine) are stored as granules in the cytoplasm until needed.. ...
The molecule behaves like an amine base, undergoing protonation and N-alkylation (e.g. Quaternium-15). The dominant use of ... Eller, K.; Henkes, E.; Rossbacher, R.; Höke, H. (2000). "Amines, Aliphatic". Ullmann's Encyclopedia of Industrial Chemistry. ... synthesis of amines from alkyl halides). Hexamethylenetetramine is the base component to produce RDX and, consequently, C-4 as ...
This process gives a variety of amines, which are separated by distillation and sublimation. The reactivity and uses of TETA ... The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of TETA. TETA ... Eller, K.; Henkes, E.; Rossbacher, R.; Höke, H. (2005). "Amines, Aliphatic". Ullmann's Encyclopedia of Industrial Chemistry. ... like many amines, assumes a yellowish color due to impurities resulting from air-oxidation. It is soluble in polar solvents. ...
Biogenic Amines. 18 (3): 319. doi:10.1163/1569391041501933. Blier; Curet, O; Chaput, Y; De Montigny, C (1991). "Tandospirone ...
Vogt, Peter F.; Gerulis, John J. (2000). "Amines, Aromatic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley- ...
... intermediate imines can also undergo attack by amine products to afford secondary and tertiary amines: 2 R-C≡N + 4 H2 → (R-CH2) ... However, other catalysts, such as cobalt boride, also can be selective for primary amine production: R-C≡N + 2 H2 → R-CH2NH2 A ... In nitrile reduction a nitrile is reduced to either an amine or an aldehyde with a suitable chemical reagent. The catalytic ... Reducing agents for the non-catalytic conversion to amines include lithium aluminium hydride, lithium borohydride, diborane, or ...
Like many amines, it gives a deep blue coloration with copper(II) solutions. Ammonia solution can dissolve silver oxide ... Eller, Karsten; Henkes, Erhard; Rossbacher, Roland; Höke, Hartmut (2000). "Amines, Aliphatic". Ullmann's Encyclopedia of ... aqueous ammonia can be used as a precursor to some alkyl amines, although anhydrous ammonia is usually preferred. ...
P. F. Vogt, J. J. Gerulis (2005). "Amines, Aromatic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi: ...
Karsten Eller; Erhard Henkes; Roland Rossbacher; Hartmut Höke (2005). "Amines, Aliphatic". Ullmann's Encyclopedia of Industrial ...
This includes amines. The dimer can be heated to regenerate the hexafluorothioacetone monomer. The dimer is also produced in a ...
Typically this reaction proceeds via the attack of the nitrosonium electrophile on an amine: NO2− + 2 H+ → NO+ + H2O R2NH + NO+ ...
... amines, behenic acid; erucyl alcohol; behenyl alcohol; wax esters; fatty acids; brassylic acid and pelargonic acid. These ...
ISBN 3-88763-075-0. E. H. Woodruff, J. P. Lambooy and W. E. Burt (1940). "Physiologically active amines. III. Secondary and ... R. V. Heinzelman (1953). "Physiologically active secondary amines. β-(o-Methoxyphenyl)-isopropyl-N-methylamine and related ...
... s also react with amines to give ureas: R2NH + R'NCO → R2NC(O)N(H)R' The addition of an isocyanate to a urea gives a ... Isocyanates are electrophiles, and as such they are reactive toward a variety of nucleophiles including alcohols, amines, and ... Isocyanates are produced by treating amines with phosgene: RNH2 + COCl2 → RNCO + 2 HCl These reactions proceed via the ... Isocyanates are common intermediates in the synthesis of primary amines via hydrolysis: Hofmann rearrangement, a reaction in ...
72, p.57 (1995) Article Baumgarten, Henry; Smith, Howard; Staklis, Andris (1975). "Reactions of amines. XVIII. Oxidative ...
Nonetheless, molecular ion peaks are weak in aliphatic amines due to the ease of fragmentation next to amines. Alpha-cleavage ... n-aliphatic amines, there is an intense peak at m/z 30. Aromatic amines have intense molecular ion peaks. For anilines, they ... Amines follow nitrogen rule. Odd molecular ion mass-to-charge ratio suggests existence of odd numbers of nitrogens. ... reactions are the most important fragmentation mode for amines; for 1° ...
Ehud, Keinan; Yehuda, Mazur (1977). "Dry ozonation of amines. Conversion of primary amines to nitro compounds". The Journal of ... Virtually all aromatic amines (anilines) are derived from nitroaromatics. A variation is formation of a dimethylaminoarene with ... Oxidation of oximes or primary amines. By decarboxylation of α-nitro carboxylic acids formed from nitriles and ethyl nitrate. ... the most important being their reduction to the corresponding amines: RNO2 + 3 H2 → RNH2 + 2 H2O Nitroalkanes are somewhat ...
Organoaluminium compounds are hard acids and readily form adducts with bases such as pyridine, THF and tertiary amines. These ... Amines give amido derivatives. With carbon dioxide, trialkylaluminium compounds give the dialkylaluminium carboxylate, and ... amines, carbon dioxide, sulfur oxides, nitrogen oxides, halogens, and halogenated hydrocarbons can be violent. Industrially, ...
Analogs of Sympathomimetic Amines". Journal of the American Chemical Society. 75 (14): 3409-3413. doi:10.1021/ja01110a033. ...
The diagnosis of SR deficiency is based on the analysis of the pterins and biogenic amines found in the cerebrospinal fluid ( ... The pterin compound functions as a cofactor in enzyme catalysis and biogenic amines which include adrenaline, dopamine, and ... The Biogenic Amines. Available from: https://www.ncbi.nlm.nih.gov/books/NBK11035/. Echenne, B., Roubertie, A., Assmann, B., ...
It is expected of aromatic amines, like o-toluidine, to be absorbable through the skin due to their lipid solubility. 48 hours ... Studies of other aromatic amines that cause bladder cancer have shown that during transport of the N-hydroxyarylamines to the ... II: Haemoglobin binding of some monocyclic aromatic amines". Arch. Toxicol. 62 (2-3): 110-115. Eyer, P. (1983). "The red cell ... doi:10.1016/0304-3835(83)90034-4. Skipper, P. L.; Tannenbaum, S. R. (1994). "Molecular dosimetry of aromatic amines in human ...
Collective Volume, 1, p. 3 Schwoegler, Edward J.; Adkins, Homer (1939). "Preparation of Certain Amines". J. Am. Chem. Soc. 61 ( ...
Eady, R.R.; Large, P.J. (1971). "Microbial oxidation of amines. Spectral and kinetic properties of the primary amine ... Methylamine dehydrogenase (amicyanin) (EC 1.4.9.1, amine dehydrogenase, primary-amine dehydrogenase) is an enzyme with ... Eady, R.R.; Large, P.J. (1968). "Purification and properties of an amine dehydrogenase from Pseudomonas AM1 and its role in ...
Secondary amines in general. The cinchona alkaloids, certain oligopeptides. Synthetic catalysts derived from biomolecules. ... Organocatalysts which display secondary amine functionality can be described as performing either enamine catalysis (by forming ... Direct Homogeneous and Heterogeneous Organic Acid and Amino Acid-Catalyzed Modification of Amines and Alcohols" Inventors: ...
Pei Y, Asif-Malik A, Canales JJ (April 2016). "Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, ... "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed ... The biogenic amines, phenethylamine and tyramine, are N-oxygenated by FMO to produce the N-hydroxy metabolite, followed by a ... Trace amines are metabolized in the mammalian body via monoamine oxidase (MAO; EC 1.4.3.4) (Berry, 2004) (Fig. 2) ... It ...
Tabor H, Mehler AH, Stadtman ER (1953). "The enzymatic acetylation of amines". J. Biol. Chem. 204 (1): 127-138. PMID 13084583. ... Weissbach H, Redfield BG, Axelrod J (1961). "The enzymic acetylation of serotonin and other naturally occurring amines". ...
Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; ...
The trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine ... It is currently thought that the biological activities elicited by trace amines such as p-tyramine and the psychostimulant ... and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor by. Bunzow JR, Sonders MS, ... These results suggest that the trace amines and catecholamine metabolites may serve as the endogenous ligands of a novel ...
Find Copper Amine Oxidases and Monooxygenases research area related information and Copper Amine Oxidases and Monooxygenases ...
Human semicarbazide-sensitive amine oxidase (SSAO) is a homodimeric copper-containing monoamine oxidase that occurs in both a ... Crystallization of a truncated soluble human semicarbazide-sensitive amine oxidase.. Jakobsson, Emma Uppsala University, ... Amine Oxidase (Copper-Containing)/*chemistry/genetics/isolation & purification, Animals, Cell Line, Crystallization, ...
... trace amine associated receptor 6) for IHC-P. Anti-Trace Amine receptor 4 pAb (GTX70805) is tested in Human samples. 100% Ab- ... 319100, Q96RI8, TA4, RP11295F4.3, Trace Amine receptor4, TAAR6, 603175, Trace Amine receptor 4, TRAR4, RP11-295F4.3, TAR4, TAR6 ... trace amine associated receptor 6. Background. TA4 is classified as an Orphan-A GPCR because the ligand has not been identified ... Storage Conditions: Trace Amine receptor 4 antibody. Storage Buffer. Phosphate buffered saline, pH 7.4 containing 0.01% sodium ...
Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimers disease and vascular ... Semicarbazide-sensitive amine oxidase (SSAO), located in outer membranes of vascular smooth muscles and endothelia, catalyzes ... Involvement of cerebrovascular semicarbazide-sensitive amine oxidase in the pathogenesis of Alzheimers disease and vascular ...
Brain Biogenic Amine Depletion and Mood. / Mendels, Joseph; Frazer, Alan.. In: Archives of General Psychiatry, Vol. 30, No. 4, ... Mendels, J., & Frazer, A. (1974). Brain Biogenic Amine Depletion and Mood. Archives of General Psychiatry, 30(4), 447-451. ... Mendels, J & Frazer, A 1974, Brain Biogenic Amine Depletion and Mood, Archives of General Psychiatry, vol. 30, no. 4, pp. 447 ... Brain Biogenic Amine Depletion and Mood. In: Archives of General Psychiatry. 1974 ; Vol. 30, No. 4. pp. 447-451. ...
T1 - Brain biogenic amine levels after methanol administration. T2 - Possible mechanism of action of central monoaminergic ... Brain biogenic amine levels after methanol administration: Possible mechanism of action of central monoaminergic neurons in ... Brain biogenic amine levels after methanol administration : Possible mechanism of action of central monoaminergic neurons in ... title = "Brain biogenic amine levels after methanol administration: Possible mechanism of action of central monoaminergic ...
Cyclic amines-Cyclic amines are either secondary or tertiary amines. Examples of cyclic amines include the 3-membered ring ... Important amines include amino acids, biogenic amines, trimethylamine, and aniline; see Category:Amines for a list of amines. ... Lower amines are named with the suffix -amine.. methylamine Higher amines have the prefix amino as a functional group. IUPAC ... "Amine definition and meaning". Collins English Dictionary. Retrieved 2017-03-28.. *^ "amine - definition of amine in English". ...
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Mohamed Amine Khamsi (born 1959 in Morocco) is an American/Moroccan mathematician. His research interests include nonlinear ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Mohamed_Amine_Khamsi&oldid=726611152" ...
Modern psychopharmacology gave rise to the amine hypotheses of affective disorders and the search began for amine metabolites ... Modern psychopharmacology gave rise to the amine hypotheses of affective disorders and the search began for amine metabolites ... Gjerris A., Rafaelsen O.J. (1985) Peptides and Amines in Affective Disorders. In: Pichot P., Berner P., Wolf R., Thau K. (eds) ... Vestergaard, P., Sorensen, R., Hoppe, E., Rafaelsen, O.J., Yates, C.M., and Nicolaou, N., 1978, Biogenic amine metabolites in ...
Alkyl Amines Chemicals Ltd has informed BSE that the meeting of the Board of Directors of the Company to be held on February 06 ... ALKYL AMINES CHEMICALS LTD.-$has informed BSE that the meeting of the Board of Directors of the Company is scheduled on 06/02/ ... ALKYL AMINES CHEMICALS LTD.-$has informed BSE that the meeting of the Board of Directors of the Company is scheduled on 06/11/ ... Alkyl Amines Chemicals Ltd has submitted to BSE the Shareholding Pattern for the Period Ended March 31, 2020. For more details ...
Disclaimer: The information provided on HealthWorld Online is for educational purposes only and IS NOT intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek professional medical advice from your physician or other qualified healthcare provider with any questions you may have regarding a medical condition ...
PRNewswire/ -- The Amines - Global Market Trajectory & Analytics report has been added to ResearchAndMarkets.coms offering. ... Fatty Amines Segment Corners a 15% Share in 2020. In the global Fatty Amines segment, USA, Canada, Japan, China and Europe will ... This segment currently accounts for a 25.9% share of the global Amines market.. The U.S. Accounts for Over 27.1% of Global ... The Amines market in the U. S. is estimated at US$4.6 Billion in the year 2020. The country currently accounts for a 27.06% ...
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Search: Amine Mezni *. Format. Summary. Summary (text). Abstract. Abstract (text). MEDLINE. XML. PMID List. MeSH and Other Data ...
Business Units sales activities of relevant amines and defined derivatives to the joint venture as well as its amines plant in ... an agreement to establish a 50-50 joint venture as the global platform for production and sales of amines and selected amines ... Germany and production output from its amines plant in Brazil.. - Headquartered in Muttenz, Switzerland, ICS has the highest ...
Benzidines/Aromatic amines. Benzidines and aromatic amines contain nitrogen atoms inside or attached to benzene-type rings. ...
PureCoat amine supports growth PureCoat amine supports growth Increase growth of human bone-marrow-derived hMSCs & hASC with ... Enhance Cell Attachment, Proliferation, and Post-thaw Recovery with Corning® PureCoat Amine Corning PureCoat Amine and Carboxyl ... Corning PureCoat Amine. Corning PureCoat Carboxyl. Applications. *Culture of primary cells, transfected, transformed, and ... Contact your authorized distributor to order PureCoat amine and carboxyl surfaces.. Contact your authorized distributor to ...
PureCoat amine supports growth PureCoat amine supports growth Increase growth of human bone-marrow-derived hMSCs & hASC with ... Enhance Cell Attachment, Proliferation, and Post-thaw Recovery with Corning® PureCoat Amine Corning PureCoat Amine and Carboxyl ... Corning PureCoat Amine. Corning PureCoat Carboxyl. Applications. *Culture of primary cells, transfected, transformed, and ... PureCoat Amine/Carboxyl. We use cookies to ensure the best experience on our website. ...
Benzidines/Aromatic amines. Benzidines and aromatic amines contain nitrogen atoms inside or attached to benzene-type rings. ...
... is a ammonium ion derivative (CHEBI:35274) methylated primary amine(1+) (CHEBI: ... CHEBI:131823 - methylated primary amine(1+). Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... An organic cation obtained by protonation of any methylated primary amine; major species at pH 7.3.. ...
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CHEBI:30631 - tris(2-aminoethyl)amine. Main. ChEBI Ontology. Automatic Xrefs. Reactions. Pathways. Models. ... N,N-bis(2,3-dihydroxybenzoyl)-N-hexanoyltren (CHEBI:51950) has functional parent tris(2-aminoethyl)amine (CHEBI:30631). ...
  • T he trace amine para-tyramine is structurally and functionally related to the amphetamines and the biogenic amine neurotransmitters. (mdma.net)
  • To evaluate the hypothesis that clinical depression is associated with reduced brain biogenic amine activity, the behavioral effects, in man, of drugs that deplete the brain of biogenic amines were reviewed. (uthscsa.edu)
  • Jeganathan, PS & Namasivayam, A 1989, ' Brain biogenic amine levels after methanol administration: Possible mechanism of action of central monoaminergic neurons in discrete areas of brain in Wistar rats ', Indian Journal of Physiology and Pharmacology , vol. 33, no. 3, pp. 151-156. (elsevier.com)
  • An extensive pharmacological survey revealed that psychostimulant and hallucinogenic amphetamines, numerous ergoline derivatives, adrenergic ligands, and 3-methylated metabolites of the catecholamine neurotransmitters are also good agonists at the rat trace amine receptor 1 (rTAR1). (mdma.net)
  • More selective amine depletion, produced either by alpha-methyl-paratyrosine or by parachlorophenylalanine is not associated with depression. (uthscsa.edu)
  • These results suggest that the trace amines and catecholamine metabolites may serve as the endogenous ligands of a novel intercellular signaling system found widely throughout the vertebrate brain and periphery. (mdma.net)
  • Here we report the discovery and pharmacological characterization of a rat G protein-coupled receptor that stimulates the production of cAMP when exposed to the trace amines p-tyramine, beta-phenethylamine, tryptamine, and octopamine. (mdma.net)
  • Villa Z / Mohamed Amine Siana" 03 Mar 2017. (archdaily.com)
  • Ludwigshafen, Germany and Shanghai, China - September 25, 2017 - BASF will build a new specialty amines plant at its existing wholly owned site in Nanjing Chemical Industry Park in China. (basf.com)
  • IUPAC however does not recommend this convention, [ citation needed ] but prefers the alkanamine form, e.g. pentan-2-amine. (wikipedia.org)
  • Amine er en av de tre stipendiatene som er en del av Dig-Eco-prosjektet (2018-2022) som retter seg mot tre aspekter av digitalisering: energi, helse og økonomi. (ntnu.no)
  • FILE - In this file photo from March 27, 2018, Morocco midfielder Amine Harit prior to the start of a friendly soccer match between Morocco and Uzbekistan in Casablanca, Morocco. (usatoday.com)
  • Rapper Amine first made international headlines when he controversially called out his fans at his 2018 Coachella gig. (mtv.com.au)
  • ZURICH--Clariant AG (CLN.VX) Friday said it and Wilmar International Limited, an Asian agribusiness group, have signed an agreement to establish a 50-50 joint venture as the global platform for production and sales of amines and selected amines derivatives. (marketwatch.com)
  • 26 October 2012 - Swiss specialty chemicals company Clariant AG (VTX:CLN) said on Friday it had agreed with Singaporean agribusiness firm Wilmar International Limited (SGX:F34) to form an equally-owned joint venture focused on production and sales of amines and selected amines derivatives globally. (thefreedictionary.com)
  • The new multi-product plant can manufacture 21,000 metric tons per year and further extends BASF's amines portfolio at the specialty amines complex in Nanjing. (basf.com)
  • This investment will help us to meet the increasing Asia Pacific demand for specialty amines used as intermediates in a diverse range of industries and applications, such as epoxy formulations, crop protection agents, spandex and biocides for the coatings industry," said Narayan Krishnamohan, Senior Vice President, Intermediates Asia Pacific, BASF. (basf.com)
  • Amines were supplied by Sigma-Aldrich and were used as received: diethyl-enetriamine-DETA (98% purity), aminoethylethanolamine--AEEA (99% purity), diethanolamine--DEA (98% purity), triethanolamine--TEA (puriss. (thefreedictionary.com)
  • Although some "trace amines" have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. (pnas.org)
  • We have demonstrated that two of these receptors bind and/or are activated by trace amines. (pnas.org)
  • The cloning of mammalian GPCRs for trace amines supports a role for trace amines as neurotransmitters in vertebrates. (pnas.org)
  • The identification of this family of receptors should rekindle the investigation of the roles of trace amines in mammalian nervous systems and may potentially lead to the development of novel therapeutics for a variety of indications. (pnas.org)
  • In addition to these classical amines, there exists a class of "trace amines" that are found in very low levels in mammalian tissues, and include tyramine, β-phenylethylamine (β-PEA), tryptamine, and octopamine ( 1 ). (pnas.org)
  • The rapid turnover of trace amines, as evidenced by their dramatic increases following treatment with monoamine oxidase (MAO) inhibitors or deletion of the MAO genes, suggests that the levels of trace amines at neuronal synapses may be considerably higher than predicted by steady-state measures ( 2 - 5 ). (pnas.org)
  • The role of trace amines as neurotransmitters in invertebrates is well established and octopamine is thought to be the sympathetic nervous system counterpart to NE ( 6 - 9 ). (pnas.org)
  • Although there is clinical literature that supports a role for trace amines in depression as well as other psychiatric disorders and migraine ( 2 , 3 , 17 - 20 ), the role of trace amines as neurotransmitters in mammalian systems has not been thoroughly examined. (pnas.org)
  • Because they share common structures with the classical amines and can displace other amines from their storage vesicles, trace amines have been referred to as "false transmitters" ( 21 ). (pnas.org)
  • Thus, many of the effects of trace amines are indirect and are caused by the release of endogenous classical amines. (pnas.org)
  • However, there is a growing body of evidence suggesting that trace amines function independently of classical amine transmitters and mediate some of their effects via specific receptors (for review, see refs. (pnas.org)
  • However, although binding sites in brain and other tissues have been reported, no specific receptors for these trace amines have yet been identified conclusively. (pnas.org)
  • We now report the identification of a family of related mammalian GPCRs of which two members have been shown to specifically bind and/or be activated by trace amines. (pnas.org)
  • A second more cathodic reduction potential appears at -1.1 V, which can be attributed to the reduction of the oxime to the primary amine, as the oxime shows a reduction potential at -1.02 V. (erowid.org)
  • A primary aliphatic amine with excellent resistance to oxidation, fluidity, low viscosity over a wide range of temperature, outstanding color stability, and high solubility in petroleum hydrocarbons. (dow.com)
  • First, the report provides a basic overview of the Amines industry including definitions, classifications, applications and industry chain structure. (pitchengine.com)
  • H-bonds form between hydrogen atoms of amines and oxygen atoms of water water is a polar solvent, and can dissolve amines, which are polar solutes nitrogen atom with a lone pair of electrons 3. (prezi.com)
  • Preparing amines from nitriles Nitriles are molecules containing the -CN group Reduction (gaining electrons) of nitriles can prepare amines A reducing agent, such as LiAIH4, is used Hydrogen bonds also exists between nitrogen atoms of amines and hydrogen atoms of water (in primary amines) 3. (prezi.com)
  • Amid the COVID-19 crisis, the global market for Amines estimated at US$16.8 Billion in the year 2020, is projected to reach a revised size of US$26.6 Billion by 2027, growing at a CAGR of 6.8% over the analysis period 2020-2027. (prnewswire.com)
  • Compounds with a nitrogen atom attached to a carbonyl group, thus having the structure R-CO-NR′R″, are called amides and have different chemical properties from amines. (wikipedia.org)
  • Preparing amines from amides Amides (organic compounds with carbonyl functional group) can be reduced to produce amines LiAlH4 can be used as a reducing agent Uses of Amines 1. (prezi.com)
  • Shape of Functional Group amines have a triangular pyramidal shape due to its three bonding electron pairs and its lone pair of electrons Reactions of Preparation 1. (prezi.com)
  • Drugs and Medication a) Chlorpheniramine inhibits immune response to relieve allergies from colds, itchy skin, insect bites, etc. b) Ephedrine and Pseudoephedrine amine drugs that are used for allergies involving respiration (decongestants) c)Chlorpromazine a tranquilizing drug used to relieve anxiety and sometimes mental disorders Chemical Properties and Reactions 1. (prezi.com)
  • Heterogeneous reactions of amines have been recently shown to play an important role in the formation and transformation of atmospheric aerosols. (rsc.org)
  • The atmospheric implications of the multiphase reactions of amines, including the potential impact on direct and indirect climate forcing of aerosols, and future research directions are discussed. (rsc.org)
  • Modern psychopharmacology gave rise to the amine hypotheses of affective disorders and the search began for amine metabolites that could fulfil our hopes for biological markers of depression and mania. (springer.com)
  • Three of the four human receptors from this family are present in the amygdala, possibly linking trace amine receptors to affective disorders. (pnas.org)
  • The Chemical Intermediates Group has an opportunity for a Technology Engineer in the Amines department located at the BASF Geismar, LA location. (aftercollege.com)
  • BASF offers a wide range of amines globally, and this investment reflects our continued commitment to meeting the growing market demand in Asia Pacific," said Stefan Blank, President, BASF Intermediates division. (basf.com)
  • With about 300 different amines, BASF has the world's most diverse portfolio of this type of chemical intermediates. (basf.com)
  • 260-465D 2 Claims ABSTRACT OF THE DISCLOSURE Hair coloring polymers having anhydride or acid halide groups, which have reacted with dyes having extra nuclear amine and/or hydroxyl groups. (google.com)
  • amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines). (wikipedia.org)
  • Basicity Amines are bases because they have an electron pair that accepts protons The lone pairs on the nitrogen atom gives amines basic properties 2. (prezi.com)
  • Amines are molecules that contain a basic nitrogen atom. (eurekalert.org)
  • 1 BASF's optimized lipase-catalyzed route to optically active amines ( Scheme 1 ) can be run at a scale of several thousand tons. (sigmaaldrich.com)
  • The lone electron pair is represented in this article by a two dots above or next to the N. The water solubility of simple amines is enhanced by hydrogen bonding involving these lone electron pairs. (wikipedia.org)
  • Amines are used widely in bioactive molecules, drugs, and various organic materials, and preparing them is one of the most important tasks for synthetic chemists in both academia and industry. (eurekalert.org)
  • Biogenic amine transporters: regulation in flux. (nih.gov)
  • Recognition that transmitters, antagonists and second messengers can modify the intrinsic activity, surface expression or protein levels of amine transporters raises new questions about the fundamental nature of drug actions in vivo. (nih.gov)
  • Amines possess a characteristic ammonia smell, liquid amines have a distinctive "fishy" smell. (wikipedia.org)
  • The bis(dimethylsilyl)amine and the bis(triorganosilyl) amine can be prepared by known methods, such as sparging an organic solvent solution of dimethylmonochlorosilane or triorganomonochlorosilane with ammonia. (google.com)
  • Bromine When halogenoalkane is added to ammonia, an amine compound is produced 2. (prezi.com)
  • The international Organisation for Economoic Co-operation and Development reported that amine oxides are not genotoxic. (ewg.org)
  • The reduction of the nitrostyrene/P2NP to the corresponding amines is not complete due to an increasing competing hydrogen evolution at the cathode with the progress of the electrolysis. (erowid.org)