Amine Oxidase (Copper-Containing)
Oxidoreductases Acting on CH-NH Group Donors
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 18.104.22.168.
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
Monoamine Oxidase Inhibitors
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
An indirect sympathomimetic. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals. Tyramine may be a neurotransmitter in some invertebrate nervous systems.
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)
An aldehyde oxidoreductase expressed predominantly in the LIVER; LUNGS; and KIDNEY. It catalyzes the oxidation of a variety of organic aldehydes and N-heterocyclic compounds to CARBOXYLIC ACIDS, and also oxidizes quinoline and pyridine derivatives. The enzyme utilizes molybdenum cofactor and FAD as cofactors.
An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC 22.214.171.124.
Oxidoreductases Acting on CH-NH2 Group Donors
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor:acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Amino Acid Oxidoreductases
Spectrum Analysis, Raman
Electron Spin Resonance Spectroscopy
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Cation Transport Proteins
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 126.96.36.199), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.
Menkes Kinky Hair Syndrome
An inherited disorder of copper metabolism transmitted as an X-linked trait and characterized by the infantile onset of HYPOTHERMIA, feeding difficulties, hypotonia, SEIZURES, bony deformities, pili torti (twisted hair), and severely impaired intellectual development. Defective copper transport across plasma and endoplasmic reticulum membranes results in copper being unavailable for the synthesis of several copper containing enzymes, including PROTEIN-LYSINE 6-OXIDASE; CERULOPLASMIN; and SUPEROXIDE DISMUTASE. Pathologic changes include defects in arterial elastin, neuronal loss, and gliosis. (From Menkes, Textbook of Child Neurology, 5th ed, p125)
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
NADH, NADPH Oxidoreductases
A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to reduce a substrate are classified according to the reverse reaction, in which NAD+ or NADP+ is formally regarded as an acceptor. This subclass includes only those enzymes in which some other redox carrier is the acceptor. (Enzyme Nomenclature, 1992, p100) EC 1.6.
L-Amino Acid Oxidase
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Amine oxidase (copper-containing)
The copper amine oxidase 3-dimensional structure was determined through X-ray crystallography. The copper amine oxidases occur ... Amine oxidase (copper-containing) (AOC) (EC 188.8.131.52 and EC 184.108.40.206; formerly EC 220.127.116.11) is a family of amine oxidase enzymes ... Yamada H, Adachi O, Ogata K (1965). "Amine oxidases of microorganisms. Part III. Properties of amine oxidase of Aspergillus ... Yamada H, Adachi O, Ogata K (1965). "Amine oxidases of microorganisms. Part IV. Further properties of amine oxidase of ...
The protein is a copper-containing primary amine oxidase enzyme. Copper amine oxidases catalyze the oxidative conversion of ... "Entrez Gene: Amine oxidase, copper containing 2". Retrieved 2015-12-31. Human AOC2 genome location and AOC2 gene details page ... Amine oxidase, copper containing 2 (AOC2) is a protein that in humans is encoded by the AOC2 gene. ... This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The ...
VAP-1 constitutes the copper dependent class of amine oxidases, such as lysyl oxidase or lysine demethylase, and is one of the ... This protein is a member of the semicarbazide-sensitive amine oxidase (SSAO; aka primary amine oxidase) family of enzymes and ... "Entrez Gene: AOC3 Amine oxidase, copper containing 3". Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, ... Amine oxidase, copper containing 3 (AOC3), also known as vascular adhesion protein (VAP-1) and HPAO is an enzyme that in humans ...
Tipping AJ, McPherson MJ (Jul 1995). "Cloning and molecular analysis of the pea seedling copper amine oxidase". The Journal of ... Primary-amine oxidase, also known as semicarbazide-sensitive amine oxidase (SSAO), is an enzyme (EC 18.104.22.168) with the ... AOC2 AOC3 Tyramine oxidase (tynA) in Escherichia coli Andrew McDonald. "Primary-amine oxidase". ExplorEnz - The Enzyme Database ... Distribution, purification and properties of two primary-amine oxidases from the yeast Candida boidinii grown on amines as sole ...
For example, copper amine oxidase, catalyzes the oxidative deamination of polyamines, especially putrescine, and releases the ... NADPH oxidase, oxalate oxidase, peroxidases, and flavin containing amine oxidases. In some cases, the cells surrounding the ... "Molecular cloning and heterologous expression of pea seedling copper amine oxidase". Bioscience, Biotechnology, and ... Other enzymes thought to play a role in ROS production include xanthine oxidase, ...
It belongs to the amine oxidase (copper-containing) (AOC) family of amine oxidase enzymes. In humans, DAO it is encoded by AOC1 ... Diamine oxidase (DAO), also known "amine oxidase, copper-containing, 1" (AOC1), formerly called histaminase, is an enzyme (EC ... "Diamine Oxidase (DAO): Benefits, Dosage, and Safety". Healthline. 2019-03-04. Retrieved 2022-07-31. Amine+Oxidase+(Copper- ... Lowered diamine oxidase values in maternal blood in early pregnancy might be an indication for trophoblast-related pregnancy ...
... copper-containing amine oxidase at 2.2 Å resolution". Structure. 4 (8): 943-955. doi:10.1016/S0969-2126(96)00101-3. PMID ... Investigation of Methionine-Copper Coordination". J. Am. Chem. Soc. 104 (20): 5364-5369. doi:10.1021/ja00384a020. Penner-Hahn, ... His research group extended its interests beyond purely organic compounds and on to metal complexes (such as copper biuret, one ... In 1970, the focus of Freeman's research became protein crystallography and he turned his attention to the blue copper proteins ...
David M. Dooley
Characterization of the Preprocessed Copper Site Equilibrium in Amine Oxidase and Assignment of the Reactive Copper Site in ... Crystal structure of a eukaryotic (pea seedling) copper-containing amine oxidase at 2.2 å resolution. Structure 4(8):943-955. ... Kβ X-ray Emission Spectroscopy as a Probe of Cu(I) Sites: Application to the Cu(I) Site in Preprocessed Galactose Oxidase. ... A Cu(I)-semiquinone state in substrate-reduced amine oxidases. Nature 349:262-264. https://www.nature.com/articles/349262a0 ...
It is used by copper amine oxidases which contain a tyrosine residue near the active site. This residue catalyses its own ...
The enzyme falls into the category of quinone-containing copper amine oxidases, and the reaction is highly dependent on the ... ISBN 978-0-8153-3218-3. Csiszar K (2001). Lysyl oxidases: a novel multifunctional amine oxidase family. Progress in Nucleic ... Csiszar K (2001). Lysyl oxidases: a novel multifunctional amine oxidase family. Progress in Nucleic Acid Research and Molecular ... Lysyl oxidase is an extracellular copper-dependent enzyme that catalyzes formation of aldehydes from lysine residues in ...
... amine oxidase, copper containing 3 This disambiguation page lists articles associated with the title AOCE. If an internal link ...
... may refer to: AOC3, Amine oxidase, copper containing 3 (vascular adhesion protein 1) N1-acetylpolyamine oxidase, an enzyme ...
... encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in ... A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting ... Lysyl oxidase homolog 4 is an enzyme that in humans is encoded by the LOXL4 gene. This gene encodes a member of the lysyl ... "Entrez Gene: LOXL4 lysyl oxidase-like 4". Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of ...
... amine oxidase A, aldehyde dehydrogenase 1A3 and membrane copper amine oxidase. Nutaratat P, Srisuk N, Arunrattiyakorn P, ... Indole-3-acetaldehyde is a substrate for retina-specific copper amine oxidase, aldehyde dehydrogenase X (mitochondrial), amine ... oxidase B, amiloride-sensitive amine oxidase, aldehyde dehydrogenase (mitochondrial), fatty aldehyde dehydrogenase, 4- ...
... encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in ... Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family". Prog. Nucleic Acid Res. Mol. Biol. Progress ... A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting ... Jung ST, Kim MS, Seo JY, Kim HC, Kim Y (2004). "Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like ...
... encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in ... Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family". Prog. Nucleic Acid Res. Mol. Biol. Progress ... Lee JE, Kim Y (2007). "A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine ... A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting ...
... encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in ... Csiszar K (2001). Lysyl oxidases: a novel multifunctional amine oxidase family. Progress in Nucleic Acid Research and Molecular ... A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting ... Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene. This gene encodes a member of the lysyl ...
... via extensive crosslinking by members of the lysyl oxidase and lysyl oxidase like family of copper-dependent amine oxidases ... and Marfan's syndrome have been associated with defects in copper metabolism and lysyl oxidase or defects in the microfibril ( ... Maintenance of crosslinked elastin is carried out by a number of proteins including lysyl oxidase-like 1 protein. Mature ... Lucero HA, Kagan HM (October 2006). "Lysyl oxidase: an oxidative enzyme and effector of cell function". Cellular and Molecular ...
... and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation, iron transportation, antioxidant and free ... Copper deficiency can be treated with either oral copper supplementation or intravenous copper. If zinc intoxication is present ... Copper is required for the functioning of many enzymes, such as cytochrome c oxidase, which is complex IV in the mitochondrial ... Copper is integrated in the enzymes cytochrome c oxidase, which is involved in cellular respiration and oxidative ...
List of MeSH codes (D08)
... amine oxidase (copper-containing) MeSH D08.811.682.664.500 - amino acid oxidoreductases MeSH D08.811.682.664.500.062 - alanine ... sarcosine oxidase MeSH D08.811.682.662.640 - proline oxidase MeSH D08.811.682.662.680 - pyridoxamine-phosphate oxidase MeSH ... proline oxidase MeSH D08.811.682.664.500.848 - protein-lysine 6-oxidase MeSH D08.811.682.664.500.924 - valine dehydrogenase ( ... galactose oxidase MeSH D08.811.682.047.239 - glucose oxidase MeSH D08.811.682.047.370 - homoserine dehydrogenase MeSH D08.811. ...
... support oxidative deamination of primary amines by passing electrons from aromatic amine dehydrogenase to cytochrome oxidase, ... A single-atom copper binding site is located about 7 Å below each monomer's surface towards its northern end; the copper atom ... Plastocyanin family of copper-binding proteins De Rienzo F, Gabdoulline RR, Menziani MC, Wade RC (August 2000). "Blue copper ... With the exception of Gly45, the copper-binding configuration above is common to the structures of all blue type 1 copper- ...
These include copper transport to deliver the Cu to extrahepatic tissues, amine oxidase activity that controls the level of ... copper ion. The two T3 copper ions are bridged by a hydroxide ligand while another hydroxide ligand links the T2 copper ion to ... Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe2+ (ferrous iron) ... The multicopper active site of CP contains a type I (T1) mononuclear copper site and a trinuclear copper center ~ 12-13 Å away ...
... is a copper oxidase that contains a type 3 di-copper cofactor and catalyzes the oxidation of ortho-diphenols ... In particular, thiol and amine functional groups on the side chains of amino acids are highly susceptible to quinone binding ... Polyphenol oxidases are a family of di-copper metalloenzymes that include tyrosinase and catechol oxidase. In plants, both ... The structural mimicry of certain copper proteins (e.g. hemocyanin, tyrosinase and catechol oxidase), containing type-3 copper ...
Nitroalkane oxidase and 3-nitropropionate oxidase oxidize aliphatic nitro compounds exclusively, whereas other enzymes such as ... Ehud, Keinan; Yehuda, Mazur (1977). "Dry ozonation of amines. Conversion of primary amines to nitro compounds". The Journal of ... Jubert, Carole & Knochel, Paul (1992). "Preparation of polyfunctional nitro olefins and nitroalkanes using the copper-zinc ... Virtually all aromatic amines (anilines) are derived from nitroaromatics. A variation is formation of a dimethylaminoarene with ...
Chelating agents − Polyphenol oxidase requires copper as a cofactor for its functionality, thus copper-chelating agents inhibit ... It is a chemical reaction that takes place between the amine group of a free amino acid and the carbonyl group of a reducing ... Generally, it is a chemical reaction involving polyphenol oxidase (PPO), catechol oxidase, and other enzymes that create ... The rate of enzymatic browning is reflected by the amount of active polyphenol oxidases present in the food. Hence, most ...
... and copper. The final step in adrenaline biosynthesis is the methylation of the primary amine of noradrenaline. This reaction ... Oanca G, Stare J, Mavri J (December 2017). "How fast monoamine oxidases decompose adrenaline? Kinetics of isoenzymes A and B ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological ... Its action is terminated with reuptake into nerve terminal endings, some minute dilution, and metabolism by monoamine oxidase ...
4-dihydroxyphenethylamine beta-oxidase 4-(2-aminoethyl) pyrocatechol beta-oxidase dopa beta-hydroxylase dopamine beta-oxidase ... Physical properties, copper content, and role of copper in the catalytic activity". The Journal of Biological Chemistry. 240 ( ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological ... DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a ...
Metal glycinate complexes, e.g. copper(II) glycinate are used as supplements for animal feeds. The U.S. "Food and Drug ... In the third pathway of its degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then ... With nitrous acid, one obtains glycolic acid (van Slyke determination). With methyl iodide, the amine becomes quaternized to ... Casari, B. M.; Mahmoudkhani, A. H.; Langer, V. (2004). "A Redetermination of cis-Aquabis(glycinato-κ2N,O)copper(II)". Acta ...
High levels of catecholamines can also be caused by monoamine oxidase A (MAO-A) deficiency, known as Brunner syndrome. As MAO-A ... Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends in Pharmacological ... The enzyme dopamine hydroxylase requires copper as a cofactor (not shown in the diagram) and DOPA decarboxylase requires PLP ( ... They can be degraded either by methylation by catechol-O-methyltransferases (COMT) or by deamination by monoamine oxidases (MAO ...
Later studies revealed that Ubiquinol oxidase activity ceases first, and the still-active cytochromes reduce the remaining ... 1 The presence of light or transition metal oxides of copper, nickel, or cobalt accelerates the exothermic[dubious - discuss] ... H2O HClO can also react with organic amines, forming N-chloroamines. Hypochlorous acid exists in equilibrium with its anhydride ... "Myeloperoxidase-mediated damage to the succinate oxidase system of Escherichia coli". J. Biol. Chem. 242: 15004-15010. doi: ...
... named for Chore Boy brand copper scouring pads) - serves as a reduction base and flow modulator in which the "rock" can be ... which then undergoes oxidative deamination by the action of diamine oxidase to yield the aminoaldehyde. Schiff base formation ... Sympathomimetic amines, Teratogens, Tropane alkaloids found in Erythroxylum coca, Vasoconstrictors, Wikipedia medicine articles ... ", "blasters" and "straight shooters". A small piece of clean heavy copper or occasionally stainless steel scouring pad - often ...
This crystal system is shared by many other metals, such as lead and copper; the size of a unit cell of aluminium is comparable ... Romero, Elvira; Ferreira, Patricia; Martínez, Ángel T.; Jesús Martínez, María (April 2009). "New oxidase from Bjerkandera ... the Claus process to convert hydrogen sulfide to sulfur in refineries and to alkylate amines. Many industrial catalysts are ... Most other metals have greater standard atomic weights: for instance, that of iron is 55.8; copper 63.5; lead 207.2. which has ...
Copper is ubiquitous and daily requirement is low making acquired copper deficiency very rare. Copper deficiency can manifest ... Broadley, KJ (March 2010). "The vascular effects of trace amines and amphetamines". Pharmacology & Therapeutics. 125 (3): 363- ... prenatal iron deficiency disrupts emotional behavior and polymorphisms that reduce the expression of monoamine oxidase interact ... Copper is important for the function of many enzymes in the brain. Notably, dopamine β-mono-oxygenase is affected by copper ...
Uses copper prosthetic groups instead of iron heme groups and is blue in color when oxygenated. Hemerythrin Some marine ... it does not compete with oxygen for the iron-binding positions but is bound to the amine groups of the protein chains attached ... they are under intense oxidative stress caused by the production of hydrogen peroxide via autoxidation and/or monoamine oxidase ...
... including cytochrome c oxidase (see Copper in health) Chromium required for sugar metabolism Iodine required not only for the ... In 1912 Casimir Funk coined the term vitamin to label a vital factor in the diet: from the words "vital" and "amine", because ... Molybdenum required for xanthine oxidase and related oxidases Selenium required for peroxidase (antioxidant proteins) Zinc ... In 1925 Hart discovered that iron absorption requires trace amounts of copper. In 1927 Adolf Otto Reinhold Windaus synthesized ...
In an ammoniacal copper solution, yellow copper oxide hydrate is formed with glucose at room temperature, while red copper ... The enzyme glucose oxidase (GOx) converts glucose into gluconic acid and hydrogen peroxide while consuming oxygen. Another ... explanation for this is that glucose has a lower tendency than other aldohexoses to react nonspecifically with the amine groups ... In Barfoed's test, a solution of dissolved copper acetate, sodium acetate and acetic acid is added to the solution of the sugar ...
AOC1 amine oxidase copper containing 1 [Homo sapiens (human)] - Gene - NCBI
Cu_amine_oxid; Copper amine oxidase, enzyme domain. pfam02727. Location:39 → 125. Cu_amine_oxidN2; Copper amine oxidase, N2 ... Cu_amine_oxid; Copper amine oxidase, enzyme domain. pfam02727. Location:39 → 125. Cu_amine_oxidN2; Copper amine oxidase, N2 ... Cu_amine_oxid; Copper amine oxidase, enzyme domain. pfam02727. Location:39 → 125. Cu_amine_oxidN2; Copper amine oxidase, N2 ... Cu_amine_oxid; Copper amine oxidase, enzyme domain. pfam02727. Location:39 → 125. Cu_amine_oxidN2; Copper amine oxidase, N2 ...
Amiloride-sensitive amine oxidase [copper-containing] | DrugBank Online
IUCr) Journal of Synchrotron Radiation Volume 18, Part 1, January 2011
Biomolecules | Free Full-Text | Histamine Intolerance: The Current State of the Art
Tavladoraki, P.; Cona, A.; Angelini, R. Copper-containing amine oxidases and FAD-dependent polyamine oxidases are key players ... Finney, J.; Moon, H.J.; Ronnebaum, T.; Lantz, M.; Mure, M. Human copper-dependent amine oxidases. Arch. Biochem. Biophys. 2014 ... Pietrangeli, P.; Federico, R.; Mondovì, B.; Morpurgo, L. Substrate specificity of copper-containing plant amine oxidases. J. ... Analysis of the distribution of copper amine oxidase in cell walls of legume seedlings. Planta 2001, 214, 37-45. [Google ...
SCOP 1.71: Family d.17.2.1: Amine oxidase N-terminal region
Copper amine oxidase, domains 1 and 2. *Family d.17.2.1: Amine oxidase N-terminal region appears in SCOP 1.69. *Family d.17.2.1 ... Amine oxidase N-terminal region. Timeline for Family d.17.2.1: Amine oxidase N-terminal region: *Family d.17.2.1: Amine oxidase ... Superfamily d.17.2: Amine oxidase N-terminal region  (1 family) *. Family d.17.2.1: Amine oxidase N-terminal region [ ... Amine oxidase N-terminal region appears in SCOP 1.73. *Family d.17.2.1: Amine oxidase N-terminal region appears in the current ...
SCOPe 2.07: Family d.82.4.1: GAS2 domain
eTOC Alert 'Pure and Applied Chemistry' - February 2020 - IUPAC | International Union of Pure and Applied Chemistry
Frontiers | DEER Data Analysis Software: A Comparative Guide
Integrated transcriptome and small RNA sequencing analyses reveal a drought stress response network in Sophora tonkinensis |...
Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a...
Copper amine oxidases are homodimeric enzymes containing one Cu(2+) ion and one 2,4,5-trihydroxyphenylalanine quinone (TPQ) per ... Previous studies with the copper amine oxidase from Escherichia coli (ECAO) have elucidated the structure of the active site ... Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a ... Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a ...
Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase<...
Amine Oxidase (Copper-Containing) Medicine & Life Sciences 97% * Methylamine Chemical Compounds 77% ... Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase. Paul J. Boor, Margaret B. Trent, ... Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase. In: Toxicology. 1992 ; Vol. 73, No. 3 ... Methylamine metabolism to formaldehyde by vascular semicarbazide-sensitive amine oxidase. / Boor, Paul J.; Trent, Margaret B.; ...
HOMD :: SEQF2888
copper amine oxidase N-terminal domain protein. 7. SEQF2888,AENP01000032.1. EFR32146.1 jb [NA] [AA] 1200/399. 77822-76623. ... dihydroorotate oxidase%2C catalytic subunit. 172. SEQF2888,AENP01000030.1. EFR32311.1 jb [NA] [AA] 312/103. 52966-52655. ... putative dihydroorotate oxidase%2C electron transfer subunit. 101. SEQF2888,AENP01000030.1. EFR32240.1 jb [NA] [AA] 468/155. ...
Quinoxalinol Based Schiff Base Ligands in Copper(II)-Mediated C-H Activation
158 Copper Amine Oxidases 8 (CAOs) are widely distributed in nature. They can be found in bacteria, yeast, plants, and mammals ... 158 Galactose Oxidase is a fungal protein consisting of a single polypeptide chain with one copper atom per active center. ... 156 For example, galactose oxidase (GOase), a copper-containing metalloenzyme secreted by the fungus Fusarium spp., is critical ... 155 Among all the transition metals, copper is of particular interest to us. Copper is widely used in metalloenzymes for oxygen ...
生藥學研究所 - 研究成果 - 臺北醫學大
Amine Oxidase (Copper-Containing) 78% * Glycation 40% * Advanced Glycation End Products 37% ... Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in ... Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. Li, P. C., Siddiqi, I. N., Mottok, A., Loo, E. Y., Wu, C ...
VAP-1 Antibodies: Novus Biologicals
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CoP: Co-expressed Biological Processes
GSE360 DC VS MAC L MAJOR UP
Amine Oxidase (Copper-Containing) Entry term(s). Amine Oxidase, Copper Amine Oxidase, Copper Containing Amine Oxidase, Copper- ... Copper Amine Oxidase Copper-Containing Amine Oxidase Diamine Oxidase Histaminase Oxidase, Copper Amine Oxidase, Copper- ... Amine oxidase (copper-containing) Entry term(s):. Amine Oxidase, Copper. Amine Oxidase, Copper Containing. Amine Oxidase, ... Amine Oxidase, Semicarbazide-Sensitive. Copper Amine Oxidase. Copper-Containing Amine Oxidase. Diamine Oxidase. Diamine Oxidase ...
Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis | eLife
The lysyl oxidase (LOX) enzymes are a family of five secreted copper-dependent amine oxidases (LOX and LOX-like (LOXL) 1 to 4) ... In situ analysis of amine oxidase activity. Request a detailed protocol An in situ assay for the detection of amine oxidase ... Lysyl oxidase-like (LOXL) enzymes and amine oxidase activity are increased in IPF tissue.. (A-E) Expression of LOX, LOXL1, ... 2006) A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate ...
Code System Concept
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Identification of Stage-Specific Breast Markers using Quantitative Proteomics<...
Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in ... Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in ... Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in ... Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in ...
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Profile for Richard Strange at the University of Essex
and Hasnain, SS., (1989). EXAFS studies on pig plasma amine oxidase. A detailed structural analysis using the curved wave ... and Hasnain, SS., (2001). X-ray structure of a blue copper nitrite reductase at high pH and in copper-free form at 1.9 Å ... Coordination geometry of copper(I) in the reduced forms of copper proteins and their derivatives with carbon monoxide. ... Exact simulation of the EXAFS of tetrabis(imidazole)copper(II) nitrate and other copper-imidazole complexes by the use of a ...
HOMD :: SEQF1622
EnzymeHomodimeric enzymesCytochromeDiamine oxidasesBovine plasmaEnzymesPolyamineLysylProteinInhibitorMonoamineExtracellularProteinsVariantsFamilyPlasmaActivityHistamineFoundActiveSolutionsPreparationMonoamine OxidaseSemicarbazide-sensitive amineLysylGlobiformisMetabolismEnzymesDopamineCeruloplasminAOC3OxidativeProteinsDiamineCofactorXanthine oxidaseAlternative oxidaseMembraneOxidationAminoSerumSubstratesQuinonePhenylethylamineColiMetabolicTissuesCandidaHomologZincHepaticIntestinalMitochondrialYeastOxidize
- Diamine oxidase enzyme: a novel biomarker in respiratory allergy. (nih.gov)
- The capacity of the vascular enzyme, semicarbazide-sensitive amine oxidase (SSAO), to metabolize methylamine to the potentially toxic product, formaldehyde, was tested using rat aortic homogenates and purified porcine aortic SSAO. (utmb.edu)
- Formaldehyde production in incubations of enzyme source with methylamine (1 mM) was detected by high performance liquid chromatography and product was confirmed by desorption chemical ionization mass spectrometry (DCI-MS). Inhibitor studies using the specific SSAO inhibitor semicarbazide and the monoamine oxidase inhibitor pargyline indicate that SSAO is responsible for metabolism of methylamine to formaldehyde. (utmb.edu)
- These enzymes catalyze the oxidative deamination of primary amines by a classical ping-pong mechanism, i.e. two distinct half-reactions, enzyme reduction by substrate followed by its re-oxidation by molecular oxygen. (unica.it)
- Under the same experimental conditions the copper-free lentil enzyme is able to generate an intermediate absorbing at about 360 nm, which is assigned to the product Schiff base quinolaldimine which, to the best of our knowledge, has never been observed during the catalytic mechanism of plant amine oxidases. (unica.it)
- 1- DAO enzyme is an amine oxidase that needs copper. (theresearchzone.com)
- Being a prominent member of the flavoprotein oxidase family, DAAO is regarded a key enzyme for understanding the flavin catalysis mechanism. (uiuc.edu)
- DOI: Amine oxidase copper containing 3 AOC3 is an enzyme that belongs to the semicarbazide-sensitive amine oxidase family, which may be a novel therapeutic target to treat diabetic complications. (kopetorpcsana.hu)
- Lysyl oxidase homolog 2 is an enzyme that in humans is encoded by the LOXL2 gene. (rockland.com)
- Copper amine oxidases are homodimeric enzymes containing one Cu(2+) ion and one 2,4,5-trihydroxyphenylalanine quinone (TPQ) per monomer. (sussex.ac.uk)
- Plant copper/quinone amine oxidases are homodimeric enzymes containing CuII and a quinone derivative of a tyrosyl residue (2,4,5-trihydroxyphenylalanine, TPQ) as cofactors. (unica.it)
- cytochrome c oxidase subunit 5A [So. (gsea-msigdb.org)
- In the further development and understanding of heme-copper dioxygen reactivity relevant to cytochrome c oxidase O 2 -reduction chemistry, we describe a high-spin, five-coordinate dioxygen (peroxo) adduct of an iron(II)-copper(I) complex, [( 6 L)Fe II Cu I ](BArF 20 ) (1), where 6 L is a tetraarylporphyrinate with a tethered tris(2-pyridylmethyl)amine chelate for copper. (elsevier.com)
- Besides the diamine oxidases (DAOs) and PA oxidase (PAOs), which catalyse the terminal catabolism of PAs in the apoplast, PAs also undergo rapid interconvertion in the PA-cycle in the peroxisomes, where the partial and/or full back-conversion of SPM to SPD and of SPD to PUT are catalyse by special PAOs (Pál et al. (heighpubs.org)
- They are oxidatively deaminated by amine oxidases including flavin adenine dinucleotide (FAD) dependent polyamine oxidases (PAO) and copper amine oxidases (CuAO) also called diamine oxidases (DAO). (wroc.pl)
- Preparation of aminomethyl propadiene by the reaction of tert-butoxycarbonylaminopropyne with formaldehyde, diisopropylamine and copper bromide, a component of many bovine plasma amine oxidase inactivators. (sincerechemical.com)
- However, in recent years specific oxygen access channels have been revealed for a number enzymes such as lipoxygenase, copper amine oxidase or glucose oxidase. (uiuc.edu)
- These polyamine oxidases are considered as prospective targets for cancer therapy.PAO-PA system has antifungal and antiparasitic activity. (bio-varbiotechnology.am)
- In ex vivo and animal models of lung fibrosis, dual inhibition of lysyl oxidase-like (LOXL) 2 and LOXL3 was sufficient to normalise collagen fibrillogenesis, reduce tissue stiffness, and improve lung function in vivo. (elifesciences.org)
- This gene encodes a member of the lysyl oxidase gene family. (rockland.com)
- Vascular adhesion protein-1 (VAP-1) is an endothelial, cell surface-expressed oxidase involved in leukocyte traffic. (perkinelmer.com)
- VAP-1 (vascular adhesion protein-1) is a copper-containing SSAO (semi-carbazide sensitive amine oxidase) with dual function. (czytelniamedyczna.pl)
- Protective effects of the novel amine-oxidase inhibitor multi-target drug SZV on streptozotocin-induced beta cell damage and diabetic complications in rats Biomed Pharmacother. (kopetorpcsana.hu)
- It is secreted by vascular smooth muscle cells, adipocytes, and endothelial cells with functional monoamine oxidase activity. (czytelniamedyczna.pl)
- The aim of the study was to assess VAP-1 levels and its correlations with renalase,which possesses possible monoamine oxidase activity, in patients on peritoneal dialyses in regard to the presence of diabetes. (czytelniamedyczna.pl)
- The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. (rockland.com)
- They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide. (bvsalud.org)
- Three target proteins, cofilin-1 and p23 (increased in invasive carcinoma) and membrane copper amine oxidase 3 (decreased in invasive carcinoma), were subjected to further validation. (york.ac.uk)
- Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. (nih.gov)
- There are many more promising candidates for oxygen access channels, especially among monooxygenases and oxidases from the flavoprotein family. (uiuc.edu)
- A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. (rockland.com)
- Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis. (nih.gov)
- Plasma diamine oxidase activity is a useful biomarker for evaluating gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer. (nih.gov)
- In this study it was observed that treatment of plants with Cd stimulated the diamine oxidase (DAO) activity twice. (wroc.pl)
- In mammals, histamine is mainly metabolized by diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT). (theresearchzone.com)
- This means that zinc-to-copper balance and copper-related diseases can affect histamine breakdown. (theresearchzone.com)
- Polyamines are aliphatic amines found in all living cells, and they are necessary for several fundamental cell processes. (heighpubs.org)
- Polyamines (PAs) are aliphatic amines found in all living cells. (heighpubs.org)
- Previous studies with the copper amine oxidase from Escherichia coli (ECAO) have elucidated the structure of the active site and established the importance in catalysis of an active-site base, Asp-383. (sussex.ac.uk)
- The interaction of xenon, in aqueous solutions, with the copper/TPQ amine oxidase from lentil (Lens esculenta) seedlings has been investigated by NMR and optical spectroscopy. (unica.it)
- Reagents for the preparation of tert-butoxycarbonyl-protected amines. (sincerechemical.com)
- Monoamine Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. (wakehealth.edu)
- Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (wakehealth.edu)
- This graph shows the total number of publications written about "Monoamine Oxidase" by people in this website by year, and whether "Monoamine Oxidase" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Monoamine Oxidase" by people in Profiles. (wakehealth.edu)
- G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. (jefferson.edu)
- Sethi D, Chen CP, Jing RY, Thakur ML, Wickstrom E. Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells. (jefferson.edu)
- Human plasma monoamine oxidase. (wikipedia.org)
- 3,4- teristic is the appearance in those neurons of Lewy bodies, dihydroxyphenylacetaldehyde (DOPAL) is an obligate intermedi- proteinaceous aggregates that contain large amounts of the 140- ate in dopamine catabolism e the product of monoamine oxidase, residue, intrinsically disordered protein a-synuclein. (nih.gov)
- The role of monoamine oxidase in cardiovascular pathophysiology has only recently gained some attention as it is demonstrated that H 2 O 2 and aldehydes may target myocardial function and consequently cardiac function. (cardiologyresearchjournal.com)
- Monoamine oxidase resides in the outer membrane of mitochondria. (cardiologyresearchjournal.com)
- The mitochondrial flavoenzymes monoamine oxidase A and B (MAO-A & MAO-B) play a major role in oxidative de-amination of biogenic amines 23 . (cardiologyresearchjournal.com)
- XADAGO is a type of prescription medicine known as a monoamine oxidase type B (MAO-B) inhibitor used with levodopa and carbidopa to treat adults with Parkinson's disease (PD) who are having 'off' episodes. (rxlist.com)
- Additionally, AA toxicity is likely dependent on the enzyme semicarbazide-sensitive amine oxidase (SSAO), which is highly expressed in the aorta of rats and humans. (nih.gov)
- Recent data suggest that the copper-containing semicarbazide-sensitive amine oxidase enzyme (SSAO) may play a role in vascular endothelial damage through conversion of certain endogenous monoamines, such as methylamine, into cytotoxic aldehydes, hydrogen peroxide and ammonia. (elitmed.hu)
- Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition. (vanderbilt.edu)
- Serial skin biopsies are required to formally assess the effect of copper treatment on lysyl oxidase (LO) activity. (medscape.com)
- Subsequent work from her group showed that the extracellular protein lysyl oxidase, responsible for collagen and elastin cross-linking, contains a lysine cross-linked variant of TPQ, while mechanistic probes advanced knowledge of cofactor biogenesis and catalysis in the copper amine oxidases. (nationalmedals.org)
- This gene encodes a member of the lysyl oxidase family of proteins. (genscript.com)
- Title: Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. (genscript.com)
- Next, we showed hypoxia enhanced breast cancer cell migration, and expression and secretion of lysyl oxidase (LOX), which is copper-dependent amine oxidase and has the primary function to drive the crosslinking of collagen and elastin and is regulated by hypoxia. (nebraska.edu)
- LOX, Lysyl oxidase is copperdependent. (adhd-npf.com)
- Because collagens and elastin are important components of the extracellular matrix, abnormalities in their modification can be expected to affect many tissues, as seen in lathyrism, a connective tissue disorder caused by the administration of ß-aminopropionitrile, an irreversible inhibitor of lysyl oxidases. (adhd-npf.com)
- The objective protein we used is a quinoprotein metalloenzyme, copper amine oxidase from Arthrobacter globiformis (AGAO), for which high-resolution X-ray and neutron crystal structures have already been determined at cryogenic temperatures. (proteopedia.org)
- Amine metabolism: a novel path to coronary artery vasospasm. (nih.gov)
- Because the new diet formulation contains components such as L-cystine and an ultratrace element mix that might affect copper metabolism, a study was done to determine if these components interfered with the effect of zinc. (usda.gov)
- Mood and thoughts are largely influenced by neurotransmitter proteins in the brain, and copper is necessary for the action of amine oxidases: enzymes that influence the metabolism of neurotransmitter proteins. (tarathornenutrition.com)
- Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus. (vanderbilt.edu)
- copper and zinc metabolism), Gig. (adhd-npf.com)
- 77 Synchronicity of ventricular contraction 78 Reflexes arising from the heart 78 Renal function 78 Extrinsic (autonomic) factors 78 Intrinsic factors (autoregulation) 79 Renal blood flow distribution 79 Kallidin and renal function 80 Catechol amines 80 Norepinephrine refractoriness 80 Action of ephedrine sulfate 80 Laboratory of kidney and electrolyte metabolism. (nih.gov)
- The current contribution reviews absorption and metabolism of copper (Cu), Cu deficiency, Cu toxicity, Cu bioavailability, and effects of pharmacological levels of Cu on growth performance and intestinal health of pigs. (biomedcentral.com)
- Manganese influences the copper and iron metabolism and estrogen therapy may raise serum manganese concentration, whereas glucosteroids alter the manganese distribution in the body. (digitalnaturopath.com)
- It is involved in the metabolism of fats and glucose, the production of cholesterol and it allows the body to use thiamine and Vitamin E. It is also involved in the building and degrading of proteins and nucleic acid, biogenic amine metabolism, which involves the transmitting of nerve impulses. (digitalnaturopath.com)
- Three fundamental issues must be addressed in configuring therapeutic strategies for individuals with Menkes kinky hair disease (MKHD): (1) the block in intestinal absorption of copper must be bypassed, (2) copper must be made available to the enzymes within cells that require it as a cofactor, and (3) infants with Menkes kinky hair disease must be identified and treatment commenced very early in life before irreparable neurodegeneration occurs. (medscape.com)
- The activities of copper enzymes, which are more difficult to study in a detailed fashion in humans than in the mouse, remain subnormal. (medscape.com)
- Copper amine oxidases certainly are a family of enzymes with quinone cofactors that oxidize primary amines to aldehydes. (plant-finder.com)
- Escherichia coli (E. coli) amine oxidase (ECAO) encoded by tynA gene has been one of the model enzymes to study the mechanism of oxidative deamination of amines to the corresponding aldehydes by amine oxidases. (omicsdi.org)
- Introduction to Metals in Biology 2018: Copper homeostasis and utilization in redox enzymes. (vanderbilt.edu)
- 2) Dithiocarbamates are capable of chelating several polyvalent inorganic ions such as copper and zinc, and thus may inactivate numerous enzymes in which these ions are essential for activity. (adhd-npf.com)
- Copper and zinc ions are essential for the prosthetic groups of many enzymes. (adhd-npf.com)
- Extracellular copper enzymes initiate the formation of the lysine and hydroxylysine derived crosslinks in collagens and lysine-derived crosslinks in elastin. (adhd-npf.com)
- These enzymes catalyze the one-electron oxidation of a wide variety of organic and inorganic substrates, including mono-, di-, and polyphenols, aminophenols, methoxyphenols, aromatic amines, and ascorbate, with the concomitant four electron reduction of oxygen to water. (ncsu.edu)
- Enzymes make-up 80-90% of viperid and 25-70% of elapid venoms: digestive hydrolases, L-amino acid oxidase, phospholipases, thrombin-like pro-coagulant, and kallikrein-like serine proteases and metalloproteinases (hemorrhagins), which damage vascular endothelium. (redefininghomeopathy.com)
- Amino acid oxidase also triggers some other enzymes and is responsible for the yellow colour of the venom of some species. (redefininghomeopathy.com)
- Increased manganese intake impairs the activity of copper metallo-enzymes. (digitalnaturopath.com)
- This is a catalytically active flavoprotein which in the presence of molecular oxygen catalyzes oxidative deamination of biogenic and dietary amines like dopamine, nor-epinephrine, serotonin, tyramine, etc. and converts them into their corresponding aldehydes and ROS 3-6 . (cardiologyresearchjournal.com)
- MAO-A appoint a FAD cofactor to catalyze oxidative deamination of various monoamines including different neurotransmitters (i.e serotonin, norepinephrine, dopamine) and some exogenous amines which are generally ingested by normal diets (tyramine) producing H 2 O 2 and relative aldehydes as by-products. (cardiologyresearchjournal.com)
- Results showed that serum ceruloplasmin amine oxidase activity, a very sensitive copper status indicator, was not affected by feeding high zinc in the diet. (usda.gov)
- Published experience on this topic indicates that parenteral administration of copper in any form restores circulating copper and ceruloplasmin to reference range levels and that oral copper does not (except copper nitriloacetate, in some patients). (medscape.com)
- Several ultrasonographically guided intramuscular injections of copper histidine raised fetal plasma copper and ceruloplasmin levels, but the distinctively abnormal plasma catechol pattern persisted. (medscape.com)
- These etiologies include biliary atresia in neonates (check with the chapter on biliary atresia), Wilson illness by ceruloplasmin and 24-hour urinary copper excretion, cystic fibrosis by sweat chloride, tyrosinemia by urinary succinyl acetone, alpha-1-antitrypsin deficiency by serum alpha-1-antitrypsin and protease inhibitor phenotyping, and autoimmune hepatitis by presence of autoantibodies and hypergammaglobulinemia (18). (thomasfuchscreative.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Amine Oxidase, Copper Containing 3 (AOC3) in samples from serum, plasma, tissue homogenates or other biological fluids. (mouseanti.com)
- Escherichia coli amine oxidase (ECAO), encoded by the tynA gene, catalyzes the oxidative deamination of aromatic amines into aldehydes through a well-established mechanism, but its exact biological role is unknown. (omicsdi.org)
- Monomeric sarcosine oxidase (MSOX) is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine (N-methylglycine) to yield glycine, formaldehyde, and hydrogen peroxide. (sigmaaldrich.com)
- Monoamine oxidases are localized in the outer membrane of mitochondria and exist as two different isoforms, MAO-A and MAO-B. MAOs are mitochondrial flavoenzymes responsible for oxidative deamination of biogenic amines and during this process, H 2 O 2 and aldehydes are generated as intermediate products. (cardiologyresearchjournal.com)
- They are copper proteins, and, as their action depends on a carbonyl group, they are sensitive to inhibition by semicarbazide. (childrensmercy.org)
- Multicopper oxidases (MCOs) constitute a group of proteins with a distinctive structure, occupying at least four copper atoms in three different copper centers T1, T2, and T3. (biomedcentral.com)
- The building blocks of proteins and polypeptides contain an acid amino group (CHOO), a basic amine group (NH2), a hydrogen atom, a variable side chain, and a central C-atom . (euro-acad.eu)
- In the digestive tract, histamine is broken down by diamine oxidase (DAO). (liacom.de)
- 1OAC has a single copper ion and a covalently bonded cofactor. (bioquest.org)
- Introduction of this pathway now opens the way to genetic/molecular biological investigations of alternative oxidase and its cofactor. (omicsdi.org)
- Copper, represents a cofactor of pyridoxol, a form of vitamin B6. (adhd-npf.com)
- 12 CUR is an excellent antioxidant and can prevent cyclo-oxygenase, lipoxygenase, and xanthine oxidase from generating free radicals. (dovepress.com)
- Multiple sources such as xanthine oxidase 18 , NADPH oxidase 19 and mitochondrial respiratory chain 20,21 can be involved in ROS generation. (cardiologyresearchjournal.com)
- Arabidopsis alternative oxidase sustains Escherichia coli respiration. (omicsdi.org)
- This implies that a single polypeptide is sufficient for alternative oxidase activity. (omicsdi.org)
- ELISA assays were developed/purchased to evaluate four candidates, that is, cartilage oligomeric matrix protein (COMP), periostin, membrane primary amine oxidase (VAP-1), and cathepsin L, in independent tissue sets. (nih.gov)
- Role for copper in transient oxidation and nuclear translocation of MTF-1, but not of NF-kappa B, by the heme-hemopexin transport system. (vanderbilt.edu)
- Microbial oxidation of amines. (wikipedia.org)
- Copper(II)-Coordinated α-Azophenols: Effect of the Metal-Ion Geometry on Phenoxyl/Phenolate Oxidation Potential and Reactivity. (univ-grenoble-alpes.fr)
- Copper(II) complex of a Schiff base of dehydroacetic acid: Characterization and aerobic oxidation of benzyl alcohol. (univ-grenoble-alpes.fr)
- It differs from other diets in that it contains nutrients that might themselves affect copper status of an animal, such as the amino acid cystine and the ultratrace nutrient nickel, and thus, lessen the effects of zinc. (usda.gov)
- A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. (genscript.com)
- Amino acid oxidases and proteases are used for digestion. (redefininghomeopathy.com)
- Coordination Chemistry of the Redox Non-Innocent Ligand Bis(2-amino-3,5-di-tert-butylphenyl)amine with Group 10 Metal Ions (Ni, Pd, Pt). (univ-grenoble-alpes.fr)
- Other status indicators such as serum copper or liver copper concentrations also were not affected by high-zinc feeding. (usda.gov)
- In rodents, the amine carboxyboranes were potent hypolipidemic agents, lowering both serum cholesterol and triglyceride concentrations, in addition to lowering cholesterol content of very low-density lipoprotein and low-density lipoprotein (LDL) and elevating high-density lipoprotein (HDL) cholesterol concentrations. (nih.gov)
- An implication is the formation of acid labile CS2 (AL CS2) will continue to increase, even at steady-state concentrations of CS2,as long as free CS2 is available to the tissue and adequate amine substrates are available. (adhd-npf.com)
- Propargylic and activated allylic amines are known to inactivate the quinone-dependent plasma amine oxidases, possibly through active-site modification by the alpha,beta-unsaturated aldehyde turnover products. (sigmaaldrich.com)
- Evidence for copper and 3,4,6-trihydroxyphenylalanine quinone cofactors in an amine oxidase from the gram-negative bacterium Escherichia coli K-12. (omicsdi.org)
- The cofactors present in a amine oxidase induced in Escherichia coli K-12 by growth on 2-phenylethylamine have been studied by spectroscopic methods. (omicsdi.org)
- Using the Protein Data Bank , we located the protein 1OAC , otherwise known as copper amine oxidase of E. coli . (bioquest.org)
- Overall design: The effect of deleting the expression of E. Coli amine oxidase by deleting tynA gene to the expression of other genes was done by comparing the knock out strain to wild type strain in different time points. (omicsdi.org)
- Copper is a micro mineral involved in metabolic reactions including cellular respiration, tissue pigmentation, hemoglobin formation, and connective tissue development. (biomedcentral.com)
- The real problem is in the cells and TISSUES , hence why a Hair Tissue Mineral Analysis is the only way to properly assess for copper toxicity. (tarathornenutrition.com)
- Role of Calprotectin in Withholding Zinc and Copper from Candida albicans. (vanderbilt.edu)
- More recently, biochemical and molecular investigations of rodent neuroglial cells have confirmed the role of the Menkes kinky hair disease homolog in delivery of copper to the brain. (medscape.com)
- For example, diets with high zinc have been shown in the past to reduce the absorption of copper into the body. (usda.gov)
- One of the diets that seems to prevent zinc from affecting copper status in adult rats is the new American Institute of Nutrition diet called AIN-93G. (usda.gov)
- We designed experiments to see if these dietary components were involved in preventing the zinc effect on copper status. (usda.gov)
- The results showed that although the component cystine affected some indicators of copper status, it in itself was not the agent affecting the interaction between copper and zinc. (usda.gov)
- Neither did the ultratrace element nutrient mix containing nickel have an effect on zinc-induced low copper status. (usda.gov)
- So, it remains a mystery why the AIN-93G diet prevents a zinc effect on copper status and some other diets do not. (usda.gov)
- Although previous studies have shown that copper status of rats is compromised when they consume a diet with high zinc, studies using the new AIN-93G rodent diet did not show this effect. (usda.gov)
- It was concluded that the lack of an effect of high zinc on copper status when using the AIN-93G diet was not the result of using L- cystine or ultratrace elements in the diet. (usda.gov)
- If you suffer with anxiety, depression, OCD, ADHD, or any kind of neurological disorder PLEASE CHECK YOUR MINERALS and see what your copper and zinc are doing. (tarathornenutrition.com)
- You also have to look at things that deplete zinc in the body because copper and zinc need to be in the right ratio and having too much of one will reduce the other. (tarathornenutrition.com)
- The hypothesis of a chelating effect has been supported by the results of some studies (4), Andreva who reported an increase in zinc and copper excretion in exposed rats, and Lukas et al. (adhd-npf.com)
- Although low hepatic copper stores are replenished quickly by parenteral therapy, brain copper during treatment increases only gradually, if at all, consistent with trapping of copper within cells comprising the blood-brain barrier. (medscape.com)
- Rats fed diets containing DL-methionine had significantly higher concentrations of liver and intestinal copper that those fed diets with L-cystine. (usda.gov)
- PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. (vanderbilt.edu)
- Dark leafy greens, dried fruits such as prunes, cocoa, black pepper, and yeast are also sources of copper in the diet. (thefreedictionary.com)
- Laccases and laccase-like multicopper oxidases (LMCOs) oxidize a vast array of phenolic compounds and amines, releasing water as a byproduct. (biomedcentral.com)