Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Rhodium: Rhodium. A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh. (Dorland, 28th ed)Hydrocarbons, Acyclic: Organic compounds composed exclusively of carbon and hydrogen where no carbon atoms join to form a ring structure.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Alanine Dehydrogenase: An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.Lycopodium: A plant genus of the family LYCOPODIACEAE. Members contain ALKALOIDS. Lycopodium oil is obtained from L. clavatum.Physicochemical Processes: Physical reactions involved in the formation of or changes in the structure of atoms and molecules and their interactions.Hydrocarbons, HalogenatedGlutamate Dehydrogenase: An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.Phosphines: Inorganic or organic compounds derived from phosphine (PH3) by the replacement of H atoms. (From Grant & Hackh's Chemical Dictionary, 5th ed)Aziridines: Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.Green Chemistry Technology: Pollution prevention through the design of effective chemical products that have low or no toxicity and use of chemical processes that reduce or eliminate the use and generation of hazardous substances.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Amino Acid Oxidoreductases: A class of enzymes that catalyze oxidation-reduction reactions of amino acids.Allyl Compounds

Reaction specificity of native and nicked 3,4-dihydroxyphenylalanine decarboxylase. (1/218)

3,4-Dihydroxyphenylalanine (Dopa) decarboxylase is a stereospecific pyridoxal 5'-phosphate (PLP)-dependent alpha-decarboxylase that converts L-aromatic amino acids into their corresponding amines. We now report that reaction of the enzyme with D-5-hydroxytryptophan or D-Dopa results in a time-dependent inactivation and conversion of the PLP coenzyme to pyridoxamine 5'-phosphate and PLP-D-amino acid Pictet-Spengler adducts, which have been identified by high performance liquid chromatography. We also show that the reaction specificity of Dopa decarboxylase toward aromatic amines depends on the experimental conditions. Whereas oxidative deamination occurs under aerobic conditions (Bertoldi, M., Moore, P. S., Maras, B., Dominici, P., and Borri Voltattorni, C. (1996) J. Biol. Chem. 271, 23954-23959; Bertoldi, M., Dominici, P., Moore, P. S., Maras, B., and Borri Voltattorni, C. (1998) Biochemistry 37, 6552-6561), half-transamination and Pictet-Spengler reactions take place under anaerobic conditions. Moreover, we examined the reaction specificity of nicked Dopa decarboxylase, obtained by selective tryptic cleavage of the native enzyme between Lys334 and His335. Although this enzymatic species does not exhibit either decarboxylase or oxidative deamination activities, it retains a large percentage of the native transaminase activity toward D-aromatic amino acids and displays a slow transaminase activity toward aromatic amines. These transamination reactions occur concomitantly with the formation of cyclic coenzyme-substrate adducts. Together with additional data, we thus suggest that native Dopa decarboxylase can exist as an equilibrium among "open," "half-open," and "closed" forms.  (+info)

Effect of the ratio between essential and nonessential amino acids in the diet on utilization of nitrogen and amino acids by growing pigs. (2/218)

In 36 growing pigs (30 to 60 kg), N balance and amino acid (AA) composition of weight gain were measured to evaluate the interactive effect of the ratio between N from essential amino acids (EAA(N)) to nonessential amino acids (NEAA(N)) and total N level (T(N)) in the diet on N retention and utilization of N, EAA(N), NEAA(N), and AA. Nine diets composed from ordinary feedstuffs and supplemented with crystalline AA were used (three EAA(N):NEAA(N) ratios of 38:62, 50:50, and 62:38 at three T(N) levels of 18.8, 22.9, and 30.0 g/kg). Pigs were fed restrictedly, at a level of 2.8 x energy for maintenance. In all diets, EAA (including arginine) supply was according to or slightly above the recommended ratios to lysine. Measurements were done in four blocks of nine pigs each. In a concomitant slaughter experiment, the AA composition of deposited body protein was determined to estimate AA utilization. The effects of T(N) and EAA(N):NEAA(N) and their interaction for N retention and utilization were significant. Nitrogen retention increased with higher T(N) in the diet. Increasing EAA(N):NEAA(N) from 38:62 to 50:50 improved N retention only at the two lower T(N) levels. Increasing EAA(N): NEAA(N) above 50:50 failed to improve N retention significantly at any of the three T(N) levels. Lowering T(N) improved the utilization of total and digested N and of EAA(N) and NEAA(N). The increase in EAA(N): NEAA(N) consistently resulted in a lower utilization of EAA(N), but this was compensated by a higher utilization of NEAA(N). The utilization of T(N) was improved by increasing EAA(N):NEAA(N) from 38:62 to 50:50 at the two lower T(N) levels and was relatively unaffected by EAA(N):NEAA(N) at the highest T(N). However, a lower utilization of N was observed at a ratio of 62:38 at a T(N) level of 22.9 g/kg. The effects were similar for utilization of individual EAA and NEAA. Utilization of alanine, aspartic acid, and glycine was close to or >100% at the highest EAA(N):NEAA(N), which was expected because all of these AA are synthesized in pigs. Also, the utilization of arginine was >100% in most of the treatments, which confirms the semiessential character of this AA for maintenance. We concluded that the required ratio of EAA(N):NEAA(N) for optimal N retention and utilization is approximately 50:50. The EAA(N):NEAA(N) is more important at lower dietary protein levels. This study indicates that EAA(N): NEAA(N) can be increased up to 70:30 without lowering the utilization of N. Thus, deaminated EAA(N) was efficiently utilized for the synthesis of NEAA(N).  (+info)

Effects of branched-chain-enriched amino acids and insulin on forearm leucine kinetics. (3/218)

Although amino acid mixtures enriched in branched-chain amino acids (BCAA) and deficient in aromatic amino acids (AAA) are often used together with insulin and glucose in clinical nutrition, their physiological effects on muscle protein anabolism are not known. To this aim, we studied forearm leucine kinetics in post-absorptive volunteers, before and after the systemic infusion of BCAA-enriched, AAA-deficient amino acids along with insulin and the euglycaemic clamp. The results were compared with the effects of insulin infusion alone. A compartmental leucine forearm model was employed at steady state. Hyperaminoacidaemia with hyperinsulinaemia (to approximately 80-100 micro-units/ml) increased the leucine plasma concentration (+70%; P<0.001), inflow into the forearm cell (+150%; P<0.01), disposal into protein synthesis (+100%; P<0.01), net intracellular retention (P<0.01), net forearm balance (by approximately 6-fold; P<0.01) and net deamination to alpha-ketoisocaproate (4-methyl-2-oxopentanoate) (+9%; P<0.05). Leucine release from forearm proteolysis and outflow from the forearm cell were unchanged. In contrast, hyperinsulinaemia alone decreased plasma leucine concentrations (-35%; P<0.001) and leucine inflow (-20%; P<0.05) and outflow (-30%; P<0.01) into and out of forearm cell(s), it increased net intracellular leucine retention (P<0.03), and it did not change leucine release from forearm proteolysis (-20%; P=0.138), net leucine deamination to alpha-ketoisocaproate, leucine disposal into protein synthesis or net forearm protein balance. By considering all data together, leucine disposal into protein synthesis was directly correlated with leucine inflow into the cell (r=0.71; P<0.0001). These data indicate that the infusion of BCAA-enriched, AAA-deficient amino acids along with insulin is capable of stimulating forearm (i.e. muscle) protein anabolism in normal volunteers by enhancing intracellular leucine transport and protein synthesis. These effects are probably due to hyperaminoacidaemia and/or its interaction with hyperinsulinaemia, since they were not observed under conditions of hyperinsulinaemia alone.  (+info)

Fluorescent neoglycolipids. Improved probes for oligosaccharide ligand discovery. (4/218)

A second generation of lipid-linked oligosaccharide probes, fluorescent neoglycolipids, has been designed and synthesized for ligand discovery within highly complex mixtures of oligosaccharides. The aminolipid 1,2-dihexadecyl-sn-glycero-3-phosphoethanolamine (DHPE), which has been used extensively to generate neoglycolipids for biological and structural studies, has been modified to incorporate a fluorescent label, anthracene. This new lipid reagent, N-aminoacetyl-N-(9-anthracenylmethyl)-1, 2-dihexadecyl-sn-glycero-3-phosphoethanolamine (ADHP), synthesized from anthracenaldehyde and DHPE gives an intense fluorescence under UV light. Fluorescent neoglycolipids derived from a variety of neutral and acidic oligosaccharides by conjugation to ADHP, by reductive amination, can be detected and quantified by spectrophotometry and scanning densitometry, and resolved by TLC and HPLC with subpicomole detection. Antigenicities of the ADHP-neoglycolipids are well retained, and picomole levels can be detected using monoclonal carbohydrate sequence-specific antibodies. Among O-glycans from an ovarian cystadenoma mucin, isomeric oligosaccharide sequences, sialyl-Lea- and sialyl-Lex-active, could be resolved by HPLC as fluorescent neoglycolipids, and sequenced by liquid secondary-ion mass spectrometry. Thus the neoglycolipid technology now uniquely combines high sensitivity of immuno-detection with a comparable sensitivity of chemical detection. Principles are thus established for a streamlined technology whereby an oligosaccharide population is carried through ligand detection and ligand isolation steps, and sequence determination by mass spectrometry, enzymatic sequencing and other state-of-the-art technologies for carbohydrate analysis.  (+info)

Structure of the Bordetella pertussis 1414 endotoxin. (5/218)

The endotoxin (lipopolysaccharide) of Bordetella pertussis, the agent of whooping cough, consists of a lipid A linked to a highly branched dodecasaccharide containing several acid and amino sugars. The elucidation of the polysaccharide structure was accomplished by first analyzing the structures of fragments obtained by hydrolysis and nitrous deamination and then piecing the fragments together. The fine structure of the antigenic distal pentasaccharide, presented here, was determined by chemical analyses as well as by high-resolution nuclear magnetic resonance and mass spectrometry. The complete structure was reconstituted and confirmed by matrix-assisted laser desorption/ionization mass spectrometry. The following structure was derived from the combined experimental data:The detailed structure combined with previously reported serological data now allows the synthesis of its epitopes for potential vaccines.  (+info)

Electrospray mass spectrometry and fragmentation of N-linked carbohydrates derivatized at the reducing terminus. (6/218)

Derivatives were prepared from N-linked glycans by reductive amination from 2-aminobenzamide, 2-aminopyridine, 3-aminoquinoline, 2-aminoacridone, 4-amino-N-(2-diethylaminoethyl)benzamide, and the methyl, ethyl, and butyl esters of 4-aminobenzoic acid. Their electrospray and collision-induced dissociation (CID) fragmentation spectra were examined with a Q-TOF mass spectrometer. The strongest signals were obtained from the [M + Na]+ ions for all derivatives except sugars derivatized with 4-amino-N-(2-diethylaminoethyl)benzamide which gave very strong doubly charged [M + H + Na]2+ ions. The strongest [M + Na]+ ion signals were obtained from the butyl ester of 4-aminobenzoic acid and the weakest from 2-aminopyridine. The most informative spectra were recorded from the [M + Li]+ or [M + Na]+ ions. These spectra were dominated by ions produced by sequence-revealing glycosidic cleavages and "internal" fragments. Linkage-revealing cross-ring cleavage ions were reasonably abundant, particularly from high-mannose glycans. Although the nature of the derivative was found to have little effect upon the fragmentation pattern, 3-aminoquinoline derivatives gave marginally more abundant cross-ring fragments than the other derivatives. [M + H]+ ions formed only glycosidic fragments with few, if any, cross-ring cleavage ions. Doubly charged molecular ions gave less informative spectra; singly charged fragments were weak, and molecular ions containing hydrogen ([M + 2H]2+ and [M + H + Na]2+) fragmented as the [M + H]+ singly charged ions with no significant cross-ring cleavages.  (+info)

Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. (7/218)

Bisulfite genomic sequencing is the method of choice for the generation of methylation maps with single-base resolution. The method is based on the selective deamination of cytosine to uracil by treatment with bisulfite and the sequencing of subsequently generated PCR products. In contrast to cytosine, 5-methylcytosine does not react with bisulfite and can therefore be distinguished. In order to investigate the potential for optimization of the method and to determine the critical experimental parameters, we determined the influence of incubation time and incubation temperature on the deamination efficiency and measured the degree of DNA degradation during the bisulfite treatment. We found that maximum conversion rates of cytosine occurred at 55 degrees C (4-18 h) and 95 degrees C (1 h). Under these conditions at least 84-96% of the DNA is degraded. To study the impact of primer selection, homologous DNA templates were constructed possessing cytosine-containing and cytosine-free primer binding sites, respectively. The recognition rates for cytosine (>/=97%) and 5-methylcytosine (>/=94%) were found to be identical for both templates.  (+info)

1-Oxo-2-hydroxy-1,2-dihydroacronycine: a useful synthon in the acronycine series for the introduction of amino substituents at 6-position and for the conversion into isopropylfuroacridones. (8/218)

Thermic aromatic nucleophilic displacement of the methoxy group at C-6 of (+/-)-1-oxo-2-hydroxy-1,2-dihydroacronycine (2) by an amine is a reaction that gives a facile entry to acronycine derivatives bearing an amino substituent at this position. The introduction of the amino substituents was confirmed with a long-range 1H-15N correlation NMR spectrum at natural abundance. Under basic conditions, compound 2 can also be rearranged to the corresponding isopropylfuroacridone 12, in 80% yield.  (+info)

*Sonogashira coupling

Sonogashira-Hagihara couplings and amination reactions". J. Organomet. Chem. 634: 39-46. doi:10.1016/S0022-328X(01)01083-X. ...

*White catalyst

The amination proceeds with high yields and good diastereoselectivity, and the products may be readily elaborated to amino ... Rice, G. T.; White, M. C. (2009). "Allylic C-H Amination for the Preparation of syn-1,3-Amino Alcohol Motifs". J. Am. Chem. Soc ... The intermolecular version of the allylic C-H amination is also known. Using methyl N-tosyl carbamate nucleophile, the linear E ... Fraunhoffer, K. J.; White, M. C. (2007). "syn-1,2-Amino Alcohols via Diastereoselective Allylic C-H Amination". J. Am. Chem. ...

*Process chemistry

... the Buchwald-Hartwig amination, Suzuki coupling and reductive amination are commonplace reactions). In contrast, process ... to develop a large-scale biocatalytic reductive amination for the final step of its sitagliptin synthesis. Codexis engineered a ...

*Chichibabin reaction

The rate of amination for three azoles proceeds quickest to slowest as follows: 1-methylbenzimidazole > 1-methylnaphth-[2,3-d] ... Amination Chichibabin, A. E.; Zeide, O. A. (1914). "[New Reaction for Compounds Containing the Pyridine Nucleus]". Zhur. Russ. ... The following is the overall form of the general reaction: The direct amination of pyridine with sodium amide takes place in ... For thermodynamically controlled additions, the rate of amination is related to the stability of the σ-adduct. Ease of hydride ...

*Amination

... is the process by which an amine group is introduced into an organic molecule. This type of reaction is important ... Amination can occur in a number of ways including reaction with ammonia or another amine such as an alkylation, reductive ... In electrophilic amination, the amine as the nucleophile react with another the organic compound as the electrophile. This ... Many alkyl amines are produced industrially by the amination of alcohols using ammonia in the presence of acid catalysts. ...

*Reductive amination

... (also known as reductive alkylation) is a form of amination that involves the conversion of a carbonyl ... ISBN 1-57259-153-6. Current methods for reductive amination Industrial Reductive amination at BASF. ... A step in the biosynthesis of many α-amino acids is the reductive amination of an α-ketoacid, usually by a transaminase enzyme ... This approach, known as direct reductive amination, employs reducing agents that are more reactive toward protonated imines ...

*Electrophilic amination

Other electron-deficient, sp3 amination reagents react by similar mechanisms to give substitution products. In aminations ... Electrophilic amination is a chemical process involving the formation of a carbon-nitrogen bond through the reaction of a ... Intramolecular amination is possible, and has been used to prepare small and medium rings. In the example below, deprotonation ... The electrophilic amination of enolates yields α-amino carbonyl compounds. When chiral oxazolidinones are used in conjunction ...

*Buchwald-Hartwig amination

The Buchwald-Hartwig amination is a chemical reaction used in organic chemistry for the synthesis of carbon-nitrogen bonds via ... A Case Study on the Origins of Competing Reduction in the Palladium-Catalyzed Amination of Aryl Halides", J. Am. Chem. Soc., ... 3.0.co;2-l Hartwig, J.F., "Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides ... Under conditions similar to those employed for amination, alcohols and can be coupled with aryl halides to produce the ...

*Umpolung

doi:10.1016/S0040-4039(00)83958-1. Erdik, E.; Ay, M. (1989). "Electrophilic amination of carbanions". Chemical Reviews. 89 (8 ... can behave as an electrophile at the nitrogen atom and react with a nucleophile as for example in the electrophilic amination ...

*Iron-sulfur world hypothesis

Huber, Claudia; Günter Wächtershäuser (February 2003). "Primordial reductive amination revisited". Tetrahedron Letters. 44 (8 ...

*Metal-catalysed hydroboration

Fernandez, E.; Maeda, K.; Hooper, M.W.; Brown, J.M. (2000). "Catalytic Asymmetric Hydroboration/Amination and Alkylamination ... "Catalytic asymmetric hydroboration-amination". Chemical Communications (2): 173. doi:10.1039/A606827H. ...

*Lithium

Amination of poly(styryl)lithium". Macromolecules. 19 (5): 1291-1294. Bibcode:1986MaMol..19.1291Q. doi:10.1021/ma00159a001. ...

*Forster-Decker method

Reductive amination Forster, Martin Onslow (1899). "XCI.-Influence of substitution on specific rotation in the bornylamine ...

*RNA world

Kumar A, Sharma S, Maurya RA (2010). "Single Nucleotide-Catalyzed Biomimetic Reductive Amination". Advanced Synthesis and ...

*Dialkylbiaryl phosphine ligands

Since then, this ligand has been utilized in multiple reactions including the amination of a wide range of aryl halides and ... XPhos was first used in 2003 for the general amination and amidation of arenesulfonates and aryl halides. XPhos has also been ... BrettPhos was originally reported in 2008 for the Pd-catalyzed amination of aryl mesylates and aryl halides. This ligand helps ... Charles, Mark D.; Schultz, Phillip; Buchwald, Stephen L. (1 September 2005). "Efficient Pd-Catalyzed Amination of Heteroaryl ...

*Nickel(II) precatalysts

Johnson, Jeffrey S.; Berman, Ashley M. (2005-07-01). "Nickel-Catalyzed Electrophilic Amination of Organozinc Halides". Synlett ... precatalysts also promote the amination of aryl chlorides, sulfamates, mesylates, and triflates. The nickel catalyst, (dppf)Ni( ... "Development of an Air-Stable Nickel Precatalyst for the Amination of Aryl Chlorides, Sulfamates, Mesylates, and Triflates". ...

*Zoltan Hajos

... and α-amination… [reactions] of carbonyl compounds. In the literature, this reaction has been referred to by different names: [ ...

*Microplasma

Klages, Claus-Peter; Alena Hinze; Peter Willich; Michael Thomas (2010). "Atmospheric-Pressure Plasma Amination of Polymer ...

*Hydroamination

Müller, T. E. Beller, M. (1998). "Metal-Initiated Amination of Alkenes and Alkynes". Chemical Reviews. 98 (2): 675-704. doi: ... doi:10.1016/s0957-4166(03)00429-4. Müller, Thomas E.; Beller, Matthias (1 April 1998). "Metal-Initiated Amination of Alkenes ... Koller, Jürgen; Bergman, Robert G. (22 November 2010). "Highly Efficient Aluminum-Catalyzed Hydro-amination/-hydrazination of ... catalytic amination of monoolefins". Journal of Molecular Catalysis. 49 (3): 235-259. doi:10.1016/0304-5102(89)85015-1. Johns, ...

*M. Christina White

Paradine, SM & White, MC (2012). "Iron-Catalyzed Intramolecular Allylic C-H Amination". Journal of the American Chemical ... most recent being the White catalyst's dehydrogenative Diels-Alder reaction and the iron-mediated intramolecular C-H amination ...

*Alfred Hassner

... electrophilic amination. Hassner's group pioneered in methodology for synthesis of small ring heterocycles such as aziridines, ...

*Nitrile

Barrault, J.; Pouilloux, Y. (1997). "Catalytic Amination Reactions: Synthesis of fatty amines. Selectivity control in presence ...

*Sodium triacetoxyborohydride

Abdel-Magid, A. F.; Mehrman, S. J. (2006). "A Review on the Use of Sodium Triacetoxyborohydride in the Reductive Amination of ... Pandit, C. R.; Mani, N. S. (2009). "Expedient reductive amination of aldehyde bisulfite adducts". Synthesis (23): 4032-4036. ... Studies on Direct and Indirect Reductive Amination Procedures1". The Journal of Organic Chemistry. 61 (11): 3849-3862. doi: ... Sodium triacetoxyborohydride is especially suitable for reductive aminations of aldehydes and ketones. However, unlike sodium ...

*CTP synthetase

Pyrimidine biosynthesis Lieberman I (1956). "Enzymatic amination of uridine triphosphate to cytidine triphosphate". The Journal ...

*Sodium cyanoborohydride

It is especially favored for reductive aminations, wherein aldehydes or ketones are treated with an amine in the presence of ... Selectivity is achieved at mildly basic solutions (pH 7-10). The reagent is ideal for reductive aminations ("Borch Reaction"). ... doi:10.1002/047084289X.rs059.pub2 Ellen W. Baxter, Allen B. Reitz Reductive Aminations of Carbonyl Compounds with Borohydride ... The commercial samples can be purified but the yields of the reductive aminations do not improve. Sodium triacetoxyborohydride ...
TY - JOUR. T1 - Acid-base blend membranes based on Nafion®/aminated SPEEK for reducing methanol permeability. AU - Tsai, Jie Cheng. AU - Lin, Chien-Kung. PY - 2011/3/1. Y1 - 2011/3/1. N2 - Sulfonated poly(ether ether ketone)s (SPEEKs) were further substituted on the polymer main chain by amino groups to form an acid-basic polymer, and blended with acid polymeric Nafion® to create composite membranes. The acid-base blend membranes containing ionic crosslinking exhibited lower water uptake than recast Nafion®, and the methanol permeability was reduced significantly for various contents of aminated SPEEK, with a maximum proton conductivity of ~0.063Scm-1 at 30°C. The single-cell performance of the blend membranes with various contents of aminated SPEEK showed 20-26mWcm-2 for S45A47 at 80°C. Both the power density and open circuit voltage were higher than those of Nafion® 115 and recast Nafion®. The acid-base blend membranes satisfy the requirements for proton exchange membranes in the ...
By substituting tetramethylated m-benzenediproprionic acid 1 via a decarboxylative metathesis of Rh2(OAc)4 (Scheme 9), the Du Bois group at Stanford has improved the catalytic performance of Rh with respect to the oxidative C-H activation of sulfamate, sulfamide, carbamate, urea, and guanidine substrates through nitrene insertion.2 High yields of tri- and tetrasubstituted amines were found by conducting the reactions under slow addition of the oxidant PhI(O2CtBu)2; which is an easily prepared, stable, and unlike PhI(OAc)2, more soluble in non-polar solvents, effective oxidant for C-H amination. The proclivity of unactivated methylene groups to undergo C-H amination is a result of the catalysts robust nature. Substrates with 3° C-H bonds are fully converted to the desired heterocycle at catalyst loadings as low as 0.15 mol %. This exceptional improvement in catalyst turnover is illustrated in Scheme 10, wherein five times the amount of the isosteric Rh2(O2Ct-Bu)4 must be applied in the ...
DNA replication is a form of template-directed polymerization that occurs with the aid of numerous enzymes. By developing a DNA replication mimic that can undergo template-directed polymerization without enzymes, the scope of template-directed polymerization will be broadened beyond biological systems. One template-directed polymerization method that has proven successful is reductive amination on a DNA template, a two-step polymerization reaction involving equilibrium imine formation followed by reduction of the imine to the amine. Because DNA-directed reductive amination is an information transfer system, it should proceed with fidelity; however, the extent of fidelity must be explored. These studies will require the ability to sequence the resulting ANP products formed under different reaction conditions Because traditional sequencing techniques for nucleic acids and polypeptides will not work to sequence ANP, we propose to study the fidelity of DNA-directed reductive amination by sequencing ...
Lamani, M. and Prabhu, K. R. (2012), NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of Propiophenones. Chem. Eur. J., 18: 14638-14642. doi: 10.1002/chem.201202703 ...
Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile access to a range of biologically interesting chiral 2-substituted hydroquinolines in up to 90% yield and with up to 93% ee. Furthermore, a significant effect of an N-protecting group was observ Synthetic methodology in OBC
Abstract. The bicyclic triaminophosphine P(i-BuNCH2CH2)3N serves as an effective ligand for the palladium-catalyzed amination of various aryl bromides and iodides. Other bicyclic or acyclic triaminophosphines, even those of similar basicity and/or bulk, were inferior.. ...
PROCESS FOR SEPARATING ONE OR MORE ALIPHATIC DIAMINES FROM REDUCTIVE AMINATION REACTION SOLVENTS AND IMPURITIES - The instant invention provides a process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities, and aliphatic diamines obtained via such a process. The process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities according to the instant invention comprises the steps of: (1) feeding one or more cycloaliphatic cyanoaldehydes, hydrogen, ammonia, and optionally one or more solvents into a continuous reductive amination reactor system; (2) contacting said one or more cycloaliphatic cyanoaldehydes, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; (3) thereby forming a product mixture comprising one or more ...
Abstract. The use of aqueous ammonia is essential for a palladium-catalyzed allylic amination for the preparation of primary amines. It is noteworthy that ammonia gas did not react at all. The first catalytic asymmetric synthesis using aqueous ammonia as a nitrogen source has also been demonstrated.. ...
Get 24/7 Reductive Amination Of Aldehydes And Ketones Assignment Help / Homework Help Online from experts on Transtutors.com. ✓25% discount ✓100% Cashback* ✓4374+ Reductive Amination Of Aldehydes And Ketones Experts. Ask Now ! Get 100% error-free solutions at affordable prices
A new procedure has been developed for the direct intermolecular C-H amination of simple hydrocarbons using shelf-stable nonafluorobutanesulfonyl azide in the presence of a dirhodium(ii) tetracarboxylate catalyst under mild reaction conditions. Some mechanistic details are briefly discussed on the basis of control
In recent years great efforts have been taken for the development of highly active catalysts in the field of hydroamination- and cross-coupling-reactions. However, there is still a lack of generally applicable and user-friendly methodologies. In the present work, a sequential protocol for the synthesis of 2-aryl/alkenyl substituted indoles using low priced 2-chloro anilines and alkynes was developed. A Broensted-acid catalyzed intramolecular hydroamination of non-activated alkenes disclosed an atom-economical approach to functionalized pyrrolidine derivatives. Air-stable heteroatom substituted secondary phosphine oxide (HASPO) TADDOLP(O)H-ligand allowed for the use of aryl chlorides in palladium-catalyzed Kumada-Corriu couplings. Easily accessible air-stable HASPO-ligand PinP(O)H enabled palladium-catalyzed Kumada-Corriu cross-couplings of not only electron-rich and electron-poor tosylates but also heterocyclic tosylates. The use of a diaminophosphine chloride as preligand in palladium-catalyzed ...
0049] Possible homogeneous catalysts to be used in the process of the invention are all homogeneous catalysts known to those skilled in the art which are able to activate the CH bond of the carbon atom bearing the OH group to be aminated. Examples of such catalysts encompass alkali metal alkoxides, aluminum alkoxides and lanthanide alkoxides, inorganic compounds of noble metals (e.g. [RuCl3*nH2O], IrCl3), monometallic or multimetallic, mononuclear or multinuclear coordination compounds of one or more noble metals selected from among the elements ruthenium (e.g. [RuCl2(PPh3)3], [RuH2(PPh3)4], the Shvo catalyst ([(η4-C4Ph4CO)Ru(CO)3]2), [Ru(cod)(cot)], [(PPh3)2Ru(CH3CN)3Cl]BPh4, [Ru(p-cymene)Cl2]2, [Ru(p-cymene)Cl2]2/DPEphos, [Ru(PPh3)3(CO)H2], [Ru3(CO)12], [Ru3(CO)12]/N-phenyl-2-(PCl2)pyrrole, [RuCl2(dmso)4]), rhodium (e.g. the Wilkinson catalyst ([RhCl(PPh3)3]), [RhH(PPh3)3]), iridium (e.g. [IrCl3(dmso)3], [Cp*IrCl2]2, [Ir(cod)Cl]2/(dppp)/Cs2CO3, [IrCl2H(cod)]2, KOH-activated ...
Sodium triacetoxyborohydride has emerged as one of the reagents used most frequently for carrying out reductive amination of carbonyl compounds, a reaction that is also known as reductive alkylation of amines. A disadvantage of sodium triacetoxyborohydride is its poor solubility, and that product isolation requires an aqueous quench followed by liquid-liquid extraction and column chromatography.. Biotage® MP-Triacetoxyborohydride was developed to perform in a manner similar to that of sodium triacetoxyborohydride, while simplifying reagent handling and product purification. Moreover, for many of these reactions, a scavenger resin may be added for one-pot purification of the product.. ...
en] This paper aims at reporting the end-functionalization of a PEO block of an amphiphilic α-acetal-PEO-b-PCL copolymer. The acetal end-group, which is the fragment of the initiator used in the EO polymerization, was first hydrolyzed into an aldehyde that was then reacted with an amine by reductive amination reaction in water. This two-step derivatization was carried out in one pot. In a preliminary study a model amine, i.e. fluorescein amine, was used and the impact of the composition, thus of the Hydrophilic-Lipophilic Balance (HLB) of the amphiphilic copolymer, was studied. The experimental conditions were extended to the coupling of an aminated mannose to the diblock copolymer. The frozen micelles formed by the mannosylated copolymer proved to form complexes with various lectins as shown by Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC ...
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This work was made possible by a grant from The Danish National Research Foundation and the EU: HMPT-CT-2001-00317. We are grateful to Dr. R. G. Hazell for X-ray crystallographic analysis. ...
The syntheses of azaMan-beta-(1--,6)-C-Glc (4), azaGlc-beta-(1--,6)-C-Glc (5), and azaGal-beta-(1--,6)-C-Glc (6) based upon double reductive amination of acetylenic carbohydrate-derived diketones is described. The required diketones are obtained by addition of the acetylenic sugar anion derived from dibromoolefin 7 to benzyl-protected mannopyranolactone, glucopyranolactone, or galactopyranolactone, followed by reduction of the ketose and oxidation of the resulting diol. Ensuing double reductive amination and hydrogenolysis affords the target compounds in reasonable to good yields. Enzyme inhibition tests show that neither of the three compounds 4, 5, and 6 inhibit beta-glycosidases, while moderate to good inhibitory activities were found on alpha-glycosidases, the most active being 6 (alpha-galactosidase: K-i = 0.092 mu M).. Keywords: carbohydrates ; aza sugars ; double reductive amination ; enzyme ; inhibitors ; glycosidase inhibitors ; Aza-c-disaccharides ; biological evaluation ; reductive ...
Organic compounds that contain nitrogen are very important intermediates in pharmaceutical and chemical industry. Hydroamination is the reaction that can form C-N bond with high atom economy. The research progress in metals catalyzed hydroamination of alkenes and alkynes from the perspective of reaction mechanism is categorized and summarized.
Tailor-made" single-cell biocatalysts co-expressing multiple enzymes enable efficient in vivo reaction cascades [28, 32]. Consequently, the design and application of such microbial cell factories has attracted attention in recent years, aiming for the production of a broad range of valuable chiral compounds. Since synthetic pathways commonly may involve cofactor-dependent redox reactions [51], various studies focused on the incorporation of reaction pathways in a host cell whereby the sequence itself enables a suitable cofactor regeneration resulting in redox self-sufficient single-cell catalysts [42, 52]. Alternatively, recycling of cofactors can be achieved by making use of the hosts inherent metabolic pathways, e.g. the catabolism of carbon sources like glucose [53]. In this study, we established a modular platform to construct E. coli single-cell biocatalysts tailored for the in vivo amination of ketoacids and prochiral ketones, exploiting both cell metabolism as well as additional ...
In this work, 3-nitro-1H-1,2,4-triazole (1) and 3,5-dinitro-1H-pyrazole (2) were C-aminated and N-aminated using different amination agents, yielding their respective C-amino and N-amino products. All compounds were fully characterized by NMR (1H, 13C, 15N), IR spectroscopy, differential scanning calorimetry (DSC). X-ray crystallographic measurements were performed and delivered insight into structural characteristics as well as inter- and intramolecular interactions of the products. Their impact sensitivities were measured by using standard BAM fallhammer techniques and their explosive performances were computed using the EXPLO 5.05 program. A comparative study on the influence of those different amino substituents on the structural and energetic properties (such as density, stability, heat of formation, detonation performance) is presented. The results showed that the incorporation of an N-amino group into a nitroazole ring can improve nitrogen content, heat of formation and impact sensitivity,
Olamide - Love No Go Dia (Amination): The YBNL Team puts out an amazing work which they decided to do something creative and iconic on Olamides new trending single
Eric Jacobsen and co-workers published in JACS on a hydroamination using a thiourea catalyst. Its refreshing to see a hydroamination without a transition metal. JACS paper
Synonyms for ex aminations at Thesaurus.com with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.
Although the Pd(II)-catalyzed alkene aminopalladation and allylic C-H activation have been much described in literature, the in-depth mechanism of such type of process is far from being a simple matter. This account focuses on the oxidative intramolecular Pd(II)-catalyzed amination of unsaturated N-sulfonyl carbamates and carboxamides, revealing that different mechanistic paths can be operative. In particular, after activation of the unsaturation by Pd(II) catalyst, aminopalladation can take place, affording the corresponding high-energy cyclic (5- or 6-membered) aminopalladated intermediate (AmPI). This latter can evolve along different pathways, such as: distocyclic β-H elimination, oxidation by a strong terminal oxidant, or carbopalladation. Otherwise, the cyclic AmPI can lay dormant, in equilibrium with the initial substrate. In this case, alternative reactivities may take place, such as allylic C-H activation of the olefinic substrate, [3,3]-sigmatropic rearrangement, or ...
The Chichibabin reaction (pronounced (chē)-chē-bā-bēn) is a method for producing 2-aminopyridine derivatives by the reaction of pyridine with sodium amide. It was reported by Aleksei Chichibabin in 1914. The following is the overall form of the general reaction: The direct amination of pyridine with sodium amide takes place in liquid ammonia. Following the addition elimination mechanism first a nucleophilic NH2− is added while a hydride (H−) is leaving. Ciganek describes an example of an intramolecular Chichibabin reaction in which a nitrile group on a fused ring is the source of nitrogen in amination. It is widely accepted that the Chichibabin reaction mechanism is an addition-elimination reaction that proceeds through an σ-adduct (Meisenheimer adduct) intermediate (the third structure). First, the nucleophilic NH2− group adds to the δ+ ring carbon pushing electrons onto the ring nitrogen and forming the anionic σ-adduct, which is stabilized by sodium. Electrons from the ...
Scientists from RUDN University in collaboration with Russian and foreign colleagues have studied reductive amination reactions. The new reactions and catalytic systems on their basis will find a use in organic synthesis and also will boost the production of medicinal substances and agrochemicals in the future. The study was published in the Organic & Biomolecular Chemistry journal.
Description: Aldehydes and ketones can be converted into amines, through formation of an imine and treatment with a reducing agent. This is called
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Researchers of the University of Amsterdams Van t Hoff Institute for Molecular Sciences (HIMS) have developed a cobalt-based catalyst for the direct synthesis of various N-heterocycles from aliphatic azides by means of intramolecular ring-closing C−H bond amination. Their result has just been published online by Chemistry, a European Journal, as a Very Important Paper.
Nicholas R. Babij and Prof. John P. Wolfe Desymmetrization of meso-2,5-Diallylpyrrolidinyl Ureas through Asymmetric Palladium-Catalyzed Carboamination: Stereocontrolled Synthesis of Bicyclic Ureas Angewandte Chemie International Edition 52. Version of Record online: 3 JUL 2013 , DOI: 10.1002/anie.201302720 ...
Transition Metal-Catalyzed Hydroamination and Carboamination Reactions of Anthranyl Allenamides as a Route to 2-Vinyl- and 2-(α-Styryl)-quinazolin-4-one Derivatives ...
phdthesis{4b0cc7a0-c1e0-4225-a218-e36a1b47d5a5, abstract = {The centenarian Trögers base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. All three diastereomers showed unprecedented stability to acid isomerization. The desymmetrization protocol presented, established the foundations for the synthesis of higher generations of fused analogues of TB.,br/,,br, Following this, new methodologies for the functionalization of both the aromatic and the methanodiazocine ring of TB were introduced. The development of a palladium-catalyzed amination conditions converted 2,8-dihalo analogues of TB to their corresponding mono- and diamino analogues. Regarding the diazocine ring, the benzylic methylenes of TB were oxidized to give the first example of a ...
Process chemistry is the arm of pharmaceutical chemistry concerned with the development and optimization of a synthetic scheme and pilot plant procedure to manufacture compounds for the drug development phase. Process chemistry is distinguished from medicinal chemistry, which is the arm of pharmaceutical chemistry tasked with designing and synthesizing molecules on small scale in the early drug discovery phase. Medicinal chemists are largely concerned with synthesizing a large number of compounds as quickly as possible from easily tunable chemical building blocks (usually for SAR studies). In general, the repertoire of reactions utilized in discovery chemistry is somewhat narrow (for example, the Buchwald-Hartwig amination, Suzuki coupling and reductive amination are commonplace reactions). In contrast, process chemists are tasked with identifying a chemical process that is safe, cost and labor efficient, "green," and reproducible, among other considerations. Oftentimes, in searching for the ...
The Netherlands Organisation for Scientific Research (NWO) has awarded chemist dr.ir. Jarl Ivar van der Vlugt of the Van t Hoff Institute for Molecular Sciences an ECHO project grant of 260,000 euros. Van der Vlugt will use the grant for the development of a novel method for the controlled, selective and efficient conversion of alkenes to amines.
ACS Amination and Hydrazine located into a single placement Water-preparation, but them are implemented into different cabinets CC1 and CC2, accordingly. Into each of the cabinets placed an individual controller, and the controller of ACS Hydrazine connected to local network through second interface of the controller of ACS Amination, where both of the interfaces connected to a Bridge. Main aim of the ACS Amination and Hydrazine is dosing transfer of ammonia and hydrazine-hydrate to the supply water, which performs by pumps connected through Frequency Converters (FC). Control by the FC performs from the PLC by the link interface RS-485 and the protocol ModBus/RTU.. ACS Phosphating divided to two parts. First part is presented by cabinet CC4 (placement of Central Heat Board) and into it installed PLC, and second part is presented by cabinet CC3 (placement of nonoperative contour of boiler #8) with a tray of Object Adjustment Devices (OAD) and frequency converters of pumps of ...
Would it be at all possible to add animation references into the ,visual_scene, tree? As an example, a new ,amination_clip_instance, element could be introduced that would be a child of (for example) the element ,instance_controller,, which would to specify animations related directly to the controller in question. The ,amination_clip_instance, could also be implemented for static geometry references (as a child of the element ,geometry_instance,) for standard mesh animation. This, I feel, would introduce the benefit that, for example, game creators would be able to identify animations directly linked to certain models within a document without having to perform additional processing to identify animation and geometry/controller links. A further benefit, this time on the readability front, would be that a person reading a document would clearly eb able to see that certain geometries/controllers were linked directly to specific animation[_clip]s through the visual scene tree ...
Mukaiyama Aldol Reaction of in situ Generated Nitrosocarbonyl Compounds: Selective C-N Bond Formation and N-O Bond Clevage in One-Pot for alpha-Amination of Ketones.. Isai Ramakrishna, Gowri Sankar Grandhi, Harekrishna Sahoo, Mahiuddin Baidya*. Chem Commun. 2015, 51, 13976-13979.. ...
Hoeksema, B. (2013). Fungia dentigera Leuckart, 1841. Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p=taxdetails&id=207347 on 2018-01- ...
SOLID-PHASE MODIFICATION WITH SUCCINIC POLYETHYLENEGLYCOL OF AMINATED LIPASE B FROM Candida antarctica: Effect of the immobilization protocol on enzyme catalytic properties ...
Magnetic Iron Oxide Nanocrystals in water coated with Dextran Available in following forms: Plain, Aminated (NH2), Carboxylated (-COOH), Avidin, Stretpavidin, Biotin, Protin A Size: 20 nm, 50 nm, 100 nm, 130 nm, 250 nm coated with Dextran: 20 nm, 50 nm, 100 nm, 130 nm, 250 nm online from Mknano.com.
Indirect reductive amination of aldehydes, catalyzed by polymer supported triphenylphosphine-palladium acetate complex PS-TPP-Pd(OAc)2 catalyst have been developed. The imine is prepared with molecular sieves in the first stage, followed by reduction with potassium formate catalyzed by PS-TPP-Pd(OAc)2. The recovered catalyst could be reused for four consecutive cycles without loss in activity and provided an excellent yield of the desired products.
The synthesis of series of diversely functionalized epsilon-morpholine amino acids (MAAs, 5a-h) starting from an epsilon-sugar amino acid and following a two-step oxidative glycol cleavage/reductive amination strategy, is described. In an alternative
With regards to conjugation to KLH, Globo-H, MUC1-32mer, GM2, Lewis Y, Tn(c), STn(c), and TF(c) were covalently attached to KLH directly by reductive amination (GM2), using the 4-(4-maleimidomethyl) cyclohexane-1-carboxyl hydrazide heterobifunctional linker group (Globo-H and Lewis Y) and using the m-malemidobenzoyl-N-hydroxysuccinimide ester heterobifunctional linker group [MUC1, Tn(c), STn (c), and TF (c)] as described previously (18, 20-25, 29). The structures of these seven conjugates are summarized in Fig. 1. Antigen and adjuvant doses were selected based on previous phase 1 monovalent vaccine trials as follows: 3 μg Tn-MUC1-32mer (24), 10 μg Globo-H (15, 22), 10 μg GM2 (30), 10 μg Lewis Y (20), 3 μg Tn(c) (23), 3 μg STn(c), 3 μg TF(c) (18), and 100 μg QS21 (15, 30). These seven conjugates and QS21 were vialed together in 1 mL PBS. Vialed samples underwent testing for toxicity and immunogenicity in mice, as well as for sterility and endotoxin. Vaccines were given s.c. on weeks 1, 2, ...
A conjugate of polyL-lysine (PLL) with unsulfated dextran produced by reductive amination was found to have remarkable anti-HIV-1 activity against both the macrophage-tropic R5 virus Ba-L and T-cell line tropic X4 virus IIIB strains, although neither PLL nor dextran has such activity. The conjugate is a pseudoproteoglycan (pseudoPG) that simulates the structure of a proteoglycan. Conjugation with dextran was found to produce an antiviral effect in three kinds of assay systems including a human CD4(+) T-cell line, and the pseudoPG synthesized using 10 kDa PLL and 10 kDa dextran showed EC(50) 4-40 times lower than that of sulfated dextran or heparin against Ba-L and EC(50) equal to that against IIIB, indicating that PLL-dextran (PLL-Dex) was more effective against R5 virus than sulfated polysaccharides ...
Affinity purified rabbit polyclonal anti-acetylated lysine antibody (anti-AcK) was developed using a unique technique that utilizes acetylated KLH as the immunogen. The purified antibody was conjugated to horseradish peroxidase (HRP) via reductive amination. Direct labelling of the primary antibody will avoid the use of secondary antibodies therefore eliminating the interference of the secondary antibody-conjugates ...
今日は昼休み中にRDKitのMMPAスクリプトをいじってました。 kzfmさんのブログを拝見させていただいたのがきっかけです。 RDKit_2013_03_2/Contrib/mmpa配下のrfag.pyの切断ルールをRECAP風にアレンジしてみました。 209行目以降 を とします。 これでエーテル、アミド、環状アミン、エステル、芳香環−芳香環、芳香族n−芳香環、スルフォンアミド、芳香環−N−芳香環(buchwald_amination)のボンドのサーチをかけてマッチした部分の結合に関わるアトムインデックスをゲッツします。 エーテルは飽和炭素ー酸素ー飽和炭素のインデックスをとるのでインデックスは前のペアと 後ろのペアを返すようにしました。 同様に芳香環−N−芳香環も同じです。 アミドやエステルはC(=O)N, C(=O
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The goal of the project is to identify and characterize populations at risk for developing pulmonary arterial hypertension (PAH). The project will establish a PAH subphenotype core cohort (CORE) to evaluate mechanistic pathways and test novel therapeutic agents. This core cohort serves as a resource for the Translational Program Project grant, Vascular Subphenotypes of Lung Disease (Mark Gladwin, PI). In order to construct the CORE, we have chosen to recruit COPD and HIV patients, two populations with advanced lung and systemic diseases that are enriched for PAH. We have selected these as prototypic conditions because: A) both COPD patients and HIV-infected patients develop PAH at a rate significantly greater than the general population, B) morbidity and mortality are greatly increased in dually-affected persons, C) mechanisms responsible for development of the PAH subphenotype are not well-understood, D) clinical and genetic characteristics of the subgroup with PAH are not known, and E) ...
The goal of the project is to identify and characterize populations at risk for developing pulmonary arterial hypertension (PAH). The project will establish a PAH subphenotype core cohort (CORE) to evaluate mechanistic pathways and test novel therapeutic agents. This core cohort serves as a resource for the Translational Program Project grant, Vascular Subphenotypes of Lung Disease (Mark Gladwin, PI). In order to construct the CORE, we have chosen to recruit COPD and HIV patients, two populations with advanced lung and systemic diseases that are enriched for PAH. We have selected these as prototypic conditions because: A) both COPD patients and HIV-infected patients develop PAH at a rate significantly greater than the general population, B) morbidity and mortality are greatly increased in dually-affected persons, C) mechanisms responsible for development of the PAH subphenotype are not well-understood, D) clinical and genetic characteristics of the subgroup with PAH are not known, and E) ...
Catalytic Hydroamination of Alkynes and Alkenes. Zhi-Yong,Han 14.Nov.,2009. Introduction Mechanistic Aspects Selected Reactions Involving Hydroamination. 1. Introduction. Problems:. slightly exothermic. but. a high reaction barrier. entropically negative. Amines: nucleophilic Slideshow 4750702 by idania
Another strained ring system that we were interested in functionalizing was [1.1.0]Bicyclobutane for the synthesis of "cyclobutylated" amines. After attempts to functionalize bicyclobutane failed, we realized that we would need an anchoring group that was attached directly to bicyclobutane to make this reaction feasible. A reaxys search revealed that substituted phenylsulfonylbicyclobutanes could be aminated under high temperature in a neat mixture. Since we believed that a method to directly append cyclobutanes onto amines would be of value, we sought out to explore ways to make this reaction broadly applicable. We started by reasoning that placement of EWGs on the phenyl ring would increase the reactivity of the central bond which could allow for milder conditions which would hopefully lead to a broad substrate scope. After synthesizing a range of substituted phenylsulfonylbicyclobutanes, we chose to move forward with the 3,5-difluoro derivative because it offered a nice balance between ...
Rosa Llusar Barelles nace en Almenara (Castellón). En 1983 se licencia en Químicas por la Universidad de Valencia obteniendo el premio extraordinario de licenciatura. Su investigación doctoral se centra en la química de sulfuros de molibdeno y wolframio y se doctora por la Universidad de Valencia en 1987 y por la Universidad de Texas A&M (EE. UU) en 1988 bajo la dirección del profesor F. Albert Cotton. Después de trabajar durante tres años como técnico superior en la sección de investigación y desarrollo de una planta de producción de caprolactama en Castellón, realiza una estancia posdoctoral de un año (1992) con el profesor John D. Corbett en el Ames Laboratory (Iowa State University, EE. UU) investigando nuevas fases sólidas de haluros reducidos de tierras raras. En 1993 accede a una plaza de profesora interina en el Departamento de Ciencias Experimentales de la Universidad Jaume I de Castellón, en 1995 pasa a ser profesora Titular de Química Física y en 2009 Catedrática de ...
In this paper, we introduce three high-performance polymers with similar structures, poly(imino ether ketone) (PIEK)s, which are synthesized by the ligand free copper-catalyzed C-N cross coupling reaction of aryl halides and primary aromatic diamines at moderate temperature. The influence of the solvents, base, temperature, and catalyst ligands on the polycondensation reaction is investigated. The structures of the polymers are characterized by means of 1H NMR spectroscopy, FTIR spectrometer and elemental analyses, and the results show a good agreement with the proposed structure. They all exhibit high glass transition temperature (Tg,170 oC), good thermal stability with high decomposition temperature (Td,5%,440 oC), and an excellent solubility in most organic solvents. In view of its good thermal stability and solubility, PIEK-1 foam with low density, 96 mg/cm3, is prepared via thermal induced phase separation and freeze-drying technology. The PIEK-1 foam possesses higher thermal stability than ...
Functionalization of MCM-41 via the reaction of its surface silanols with proper agents yielded aminated and phosphinated materials, which were characterized and used to immobilize rhodium complex. These rhodium complex materials exhibited excellent performance in the hydrogenation of arenes under mild reaction conditions of 45°C and 1 atm. © 2001 Elsevier Science B.V ...
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Research in the Widenhoefer group is directed toward the development and mechanistic analysis of new organotransition metal-catalyzed transformations for application in the synthesis of functionalized organic molecules. In particular, our group has a long-standing interest in the functionalization of C-C multiple bonds with carbon and heteroatom nucleophiles catalyzed by electrophilic late transition metal complexes, with a recent focus on the synthetic and mechanistic aspect of gold(I) pi-activation catalysis. Current areas of inquiry include the following: 1) Gold(I) and Pt(II)-catalyzed hydroamination of alkenes an allenes. 2) Gold(I)-catalyzed dehydrative amination of underivatized allylic alcohols. 3) Synthesis and study of cationic, two-coordinate gold pi-complexes. 4) Evaluating the role of bis(gold) complexes in gold pi-activation catalysis. More detailed descriptions of these research projects can be found at our group web page.. ...
Research in the Widenhoefer group is directed toward the development and mechanistic analysis of new organotransition metal-catalyzed transformations for application in the synthesis of functionalized organic molecules. In particular, our group has a long-standing interest in the functionalization of C-C multiple bonds with carbon and heteroatom nucleophiles catalyzed by electrophilic late transition metal complexes, with a recent focus on the synthetic and mechanistic aspect of gold(I) pi-activation catalysis. Current areas of inquiry include the following: 1) Gold(I) and Pt(II)-catalyzed hydroamination of alkenes an allenes. 2) Gold(I)-catalyzed dehydrative amination of underivatized allylic alcohols. 3) Synthesis and study of cationic, two-coordinate gold pi-complexes. 4) Evaluating the role of bis(gold) complexes in gold pi-activation catalysis. More detailed descriptions of these research projects can be found at our group web page.. ...
Abstract Phenylacetoacetonitrile APAAN is one of the most important preprecursors for amphetamine production in recent years. This assumption is based on seizure data but there is little analytical data available showing how much amphetamine really originated from APAAN. In this study, several syntheses of amphetamine following the Leuckart route...
Another strained ring system that we were interested in functionalizing was [1.1.0]Bicyclobutane for the synthesis of "cyclobutylated" amines. After attempts to functionalize bicyclobutane failed, we realized that we would need an anchoring group that was attached directly to bicyclobutane to make this reaction feasible. A reaxys search revealed that substituted phenylsulfonylbicyclobutanes could be aminated under high temperature in a neat mixture. Since we believed that a method to directly append cyclobutanes onto amines would be of value, we sought out to explore ways to make this reaction broadly applicable. We started by reasoning that placement of EWGs on the phenyl ring would increase the reactivity of the central bond which could allow for milder conditions which would hopefully lead to a broad substrate scope. After synthesizing a range of substituted phenylsulfonylbicyclobutanes, we chose to move forward with the 3,5-difluoro derivative because it offered a nice balance between ...
Another strained ring system that we were interested in functionalizing was [1.1.0]Bicyclobutane for the synthesis of "cyclobutylated" amines. After attempts to functionalize bicyclobutane failed, we realized that we would need an anchoring group that was attached directly to bicyclobutane to make this reaction feasible. A reaxys search revealed that substituted phenylsulfonylbicyclobutanes could be aminated under high temperature in a neat mixture. Since we believed that a method to directly append cyclobutanes onto amines would be of value, we sought out to explore ways to make this reaction broadly applicable. We started by reasoning that placement of EWGs on the phenyl ring would increase the reactivity of the central bond which could allow for milder conditions which would hopefully lead to a broad substrate scope. After synthesizing a range of substituted phenylsulfonylbicyclobutanes, we chose to move forward with the 3,5-difluoro derivative because it offered a nice balance between ...
Solid-phase carrier for aminated oligonucleotide | Carrier for undifferentiated cell culture and subculture method thereof | Lubricant coating for laser printer wiper blades | Fast curing adhesive useful for bonding to glass | Hot melt ink |
Novel 3-O-1,2;5,6-di-O-isopropylidene-alpha-D-glueofuranose] and 3-O-D-glucose] derivatives with an iminodiacetate (N,O,O), a histidinate, and an N-(acetetyl)picolylamine (N,N,O) chelating system for tridentate coordination of the organometallic M(CO)(3)-fragment (M = Tc, Re) have been prepared. The chelates were introduced and assembled through reductive amination starting from 3-O-1,2;5,6-di-O-isopropylidene-alpha-D-glucofuranose]-acetaldehyde. After deprotection, the pyranose derivatives were reacted with the precursor NEt4](2)ReBr3(CO)(3)] to afford the corresponding organometallic complexes in yields between 54% and 94%. The NMR, MS, and IR analyses corroborated the tridentate coordination of the organometallic metal center exclusively via the synthetic chelates. In the case of the N-(acetyl)picolylamine derivative, the coordinative properties were further confirmed by X-ray structure analysis of the first Re(CO)(3)-D-glucofuranose complex. All glucose complexes unveiled good stability and ...
Tanvir Arfin. 5.1 History 115. 5.2 Synthesis of Chitosan 116. 5.3 General Properties 117. 5.4 Biological Properties 117. 5.5 Physicochemical Aspects 118. 5.6 Molecular Weight 118. 5.7 Stability 118. 5.8 Fabrication 119. 5.9 Self-Assembly 120. 5.10 Strategies Self-Assembly 121. 5.11 Chief Significance 122. 5.12 Various Forms 122. 5.13 Chemical Modification 122. 5.14 Technologic Features for Medicinal Utilization 122. 5.15 Synthetic Procedure of Chitosan Nanoparticles 123. 5.16 Modified Chitosan 123. 5.17 Carboxymethyl Chitosan (CMC) 123. 5.18 Michael Reaction 124. 5.19 Antioxidant 124. 5.20 Antibacterial Properties 126. 5.21 Antimicrobial Activity 126. 5.22 Antiviral Activity 129. 5.23 Biological Adhesive 129. 5.24 Bonding Purposes 130. 5.25 Biodegradation 130. 5.26 Parameter Moving Transfection Competence 131. 5.27 Conjugation 131. 5.28 Functionalization of Chitosan 131. 5.29 Schiff s Base Formation 131. 5.30 Reductive Amination 134. 5.31 Chitosan-Proteins Interaction 134. 5.32 Absorption ...
The syntheses of two chromophore-appended dipicolylamine-derived ligands and their reactivity with pentacarbonylchlororhenium have been studied. The resultant complexes each possess the fac-Re(CO)3 core. The ligands L1 1-[bis(pyridine-2-ylmethyl)amino]methylpyrene and L2 2-[bis(pyridine-2-ylmethyl)amino]methylquinoxaline were isolated via a one-pot reductive amination in moderate yield. The corresponding rhenium complexes were isolated in good yields and characterised by 1H NMR, MS, IR and UV-Vis studies. X-Ray crystallographic data were obtained for fac-{Re(CO)3( L1)}(BF4), C34H26BF4N4O3Re: monoclinic, P2(1)/c, a = 18.327(2) , = 90.00°, b = 14.1537(14) , = 96.263(6)°, c = 23.511(3) , = 90.00°, 6062.4(11) 3, Z = 8. The luminescence properties of the ligands and complexes were also investigated, with the emission attributed to the appended chromophore in each case. Isothermal titration calorimetry suggests that fac-{Re(CO)3( L1)}(BF4) self-aggregates cooperatively in aqueous solution, probably ...
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea ...
2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate) and 2-oxoglutarate. This diagram illustrates the architecture of chain extension and modification reaction modules for 2-oxocarboxylic acids. The chain extension module RM001 is a tricarboxylic pathway where acetyl-CoA derived carbon is used to extend the chain length by one. The chain modification modules RM002 (including RM032) and RM033, together with a reductive amination step (RC00006 or RC00036), generate basic and branched-chain amino acids, respectively. The modification module RM030 is used in the biosynthesis of glucosinolates, a class of plant secondary metabolites, for conversion to oxime followed by addition of thio-glucose moiety. Furthermore, the chain extension from 2-oxoadipate to 2-oxosuberate is followed by coenzyme B biosynthesis in methonogenic archaea ...
All influences help the highest download Sarah\s for baby and block from Once Greek problems and concepts. aggressive metafont of Furans: Merino, P. The Tishchenko Reaction: Koskinen, A. Ring-Expanding Carbonylation of claims: Kramer, J. Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles: Shaughnessy, K. The Wacker Oxidation: Michel, B. The Boronic Acid Mannich Reaction: Pyne, S. Catalytic Asymmetric Ketene 2 + 2 and 4 + 2 notes: Nelson, S. Krapcho Dealkoxycarbonylation Reaction of Esters with refreshing PaperbackI: Krapcho, A. URLs of resource Budgets continued from link Oximes: Hodgson, D. Catalytic, actual, Acceptable Spine website: Doyle, M. Asymmetric pelos by Auditor helping Chiral Lithium Amides: Simpkins, N. Cross-coupling cookies of Organotrifluoroborate Salts: Molander, G. The Neber Rearrangement: Berkowitz, William F. Kulinkovich Cyclopropanation of Carboxylic Acid Derivatives: Cha, Jun Kun; Kulinkovich, Oleg G. Hydrocyanation of Alkenes and Alkynes: Rajanbabu, Thaliyil V.
This study focuses on the investigation of the phase behavior of mixtures relevant to the direct synthesis of dimethyl carbonate from methanol and carbon dioxide. The bubble points of corresponding quaternary mixtures of varying composition were experimentally determined. The Cubic-Plus-Association (CPA) equation of state was applied to model the phase behavior of the experimentally studied systems. In this regard, the CPA binary interaction parameters were estimated based on experimental data for the corresponding binary systems available in the literature, and subsequently the model was applied to predict the phase behavior of the multicomponent systems. It was shown that CPA is capable of predicting the phase behavior of such complex systems containing polar and associating components at high temperatures and pressures with reasonable accuracy considering the non-ideality of such mixtures. The results reveal P-T regions where the system can exist in one single phase and where it is ...
Amine synthesis, Buchwald-Hartwig amination, Cyanide synthesis, Ether synthesis, Stille reaction, Suzuki reaction, Thioether synthesis, Urea synthesis.
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Plays an important role in the regulation of phospholipid synthesis.
Background Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. Description CTPS2...
Success demonstrate that neither W94A nor W127A sig nicantly hinder LRT selleck accumulation, whereas wild kind A3G and E259Q reduced these ranges by selleck chemical NVP-BKM120 forty 60% for each viruses.A3G and E259Q had significantly much more dramatic effects on integration with measured reductions of 94 and 89% for HIV and 92 and 81% for MoMLV, respectively.These effects clearly reveal the marginal part of de amination in preventing these two early measures within the infec tion. Then again, W94A had no signicant effect on decreasing the proviral integration of both MoMLV or HIV. Equally, W127A did not lessen the integration of HIV, but appeared to possess a slight impact on MoMLV. Inactivation of the deaminase activity from the W94A RNA binding mutant had no detectable impact on LRT accumulation or integration, which once more supports that deamination is not really a serious contributor in preventing these specic processes. Hypermutation will not have an impact on MoMLV particle release ...
Palladium has a rich organometallic chemistry which has developed over the past twenty-five years. While palladium is not unique in its ability to carry out a wide range of carbon-carbon bond forming reactions, its ver- satility has resulted in an increasing effort being made towards the use of palladium reagents in organic synthesis in academic and industrial research laboratories.Widely used procedures such as the Heck, Suzuki and Sonogashira cross-coupling reactions and Buckwald-Hartwig aminations most commonly employ a palladium-based catalyst ...
Broadening the Scope of Catalytic Hydroamination using Simple Ureate Ligands: Evidence for Concerted C-N, C-H bond formation at Zirconium ...
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University of Alberta chemistry researchers have discovered an active catalyst that has the potential to improve the efficiency and environmental impact of manufacturing processes
Catalysis is astonishing. Very small quantities of the most active catalysts can convert thousands or millions of times their own weight of chemicals. Equally astonishing is just how selective they can be. A catalyst may increase the rate of only one reaction out of many competing reactions.. ...
Manolikakes, Georg (2009): Transition-Metal Catalyzed Cross-Coupling Reactions of Functionalized Organometallic Reagents, Nickel-Catalyzed Amination of Aryl Chlorides and Preparation and Reactions of Organozinc Reagents. Dissertation, LMU München: Fakultät für Chemie und Pharmazie ...
The research presented in this thesis describes the application of phenylalanine ammonia lyase from the bacteria Anabaena variabilis (AvPAL), as a biocatalyst for the asymmetric hydroamination of cinnamic acid derivatives. PALs from eukaryotic sources such as the plant Petroselinum crispum (PcPAL) and yeast Rhodotorula glutinis (RgPAL) have been widely used as biocatalysts for the synthesis of non-natural amino acids. For example the PAL catalyzed hydroamination of 2-chlorocinnamic acid has been implemented by DSM Pharma Chemicals on a tonne scale. However, there are very few examples of prokaryotic PALs and to our knowledge their activity towards unnatural substrates has not been investigated. Herein we explore the activity of AvPAL towards a panel of cinnamic acid analogues. For comparison, the activity of the commonly studied eukaryotic PcPAL and RgPAL towards the same substrate panel was also investigated. Although the difference in substrate conversions between the three PALs was fairly ...
TPGS-750-M, a second generation surfactant, is useful for room temperature, palladium and ruthenium-catalyzed reactions in water. Reactions include the Heck reaction, Suzuki-Miyaura reaction, Sonogashira reaction, Buchwald-Hartwig amination reaction, Negishi reaction, and olefin metathesis.
Summary of Facts and Submissions. I. European patent No. 0 050 800 was granted on the basis of Claims 1 to 15 for the contracting states other than Austria and of Claims 1 to 14 for Austria contained in European patent application No. 81 108 348.4. Claim 1 reads as follows:. 1. A compound of the formula. (FORMULA). or a pharmaceutically acceptable salt thereof, wherein R and R6 are the same or different and are hydroxy, lower alkoxy, lower alkenyloxy, dilower alkylamino lower alkoxy, acylamino lower alkoxy, acyloxy lower alkoxy, aryloxy, aryllower alkoxy, amino, lower alkylamino, dilower alkylamino, hydroxyamino, aryllower alkylamino, or substituted aryloxy or substituted aryllower alkoxy wherein the substituent is methyl, halo or methoxy; R1 is hydrogen, alkyl of from 1 to 10 carbon atoms, substituted lower alkyl wherein the substituent is hydroxy, lower alkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, amino, lower alkylamino, diloweralkylamino, acylamino, ...
Controlled integration of features that improve the analytical performance of the sensor chip is a challenging task in the introduction of paper receptors. asymmetric extending, 2886 cmC1 with CH2 symmetric extending, and 1390 cmC1 with CH3 symmetric deformation.32 The intense, multiple peaks at 1078, 1112, and 1182 cmC1 match SiCOCSi vibration and SiCOCC that can be found both in the majority of the finish with the cellulose user interface.33 The IR absorption bands of hydrocarbon-related and amine functionalities act like that of the alkyl amine functionalities, except for the excess siloxane peaks due to the silane precursor.34 Amount 3 (a) FTIR spectral range of amine-functionalized finish. (b) C 1s core-level photoemission spectroscopy of neglected paper (dark track) Indapamide (Lozol) manufacture and amine-functionalized cellulose (green track). (c) C XAS Indapamide (Lozol) manufacture of neglected paper (dark track) and aminated paper (green track). … The C 1s core-level photoemission ...
Alanine dehydrogenase catalyses the NAD-dependent reversible reductive amination of pyruvate into alanine. Pyridine nucleotide transhydrogenase catalyses the reduction of NADP+ to NADPH with the concomitant oxidation of NADH to NAD+. This enzyme is located in the plasma membrane of prokaryotes and in the inner membrane of the mitochondria of eukaryotes. The transhydrogenation between NADH and NADP is coupled with the translocation of a proton across the membrane. In prokaryotes the enzyme is composed of two different subunits, an alpha chain (gene pntA) and a beta chain (gene pntB), while in eukaryotes it is a single chain protein.. The sequence of alanine dehydrogenase from several bacterial species is related with that of the alpha subunit of bacterial pyridine nucleotide transhydrogenase and the N-terminal half of the eukaryotic enzyme. The two most conserved regions correspond respectively to the N-terminal domain of these proteins, and to a central glycine-rich region which is part of the ...
The immunogen is Aflatoxin B1 (AFB1)-BSA conjugates. The antibody was affinity purified with an AFB1-Agarose column and competitively eluted by free AFB1. The antibody was conjugated to peroxidase (HRP) by reductive amination. This anti-AFB1 HRP conjugates could be utilized for detection and quantization of the food-borne mycotoxin AFB1. ...
Yang,k.; Li, Q.; Liu, Y.-B.;Li, G.-G.;Ge, H.-B. Catalytic C−H arylation of aliphatic aldehydes enabled by a transient ligand. J. Am. Chem. Soc. 2016, 138, 12775-12778.. Liu, Y.-B.; Ge, H.-B. Site-selective C-H arylation of primary aliphatic amines enabled by a catalytic transient directing group. Nat. Chem. 2016, in press, doi:10.1038/nchem.2606.. Wu, X.-S.; Zhao, Y.; Ge, H.-B. Direct aerobic carbonylation of C(sp2)−H and C(sp3)−H bonds through Ni/Cu synergistic catalysis with DMF as the carbonyl source. J. Am. Chem. Soc. 2015, 137, 4924-4927. Wu, X.-S.; Yang, K.; Zhao, Y.; Sun, H.; Li, G.-G.; Ge, H.-B. Cobalt-catalyzed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons. Nat. Commun. 2015, 6, 6462-6468.. Wu, X.-S.; Zhao, Y.; Ge, H.-B. Nickel-catalyzed site-selective alkylation of unactivated C(sp3)−H bonds. J. Am. Chem. Soc. 2014, 136, 1789-1792.. Wu, X.-S.; Zhao, Y.; Zhang, G.-W.; Ge, H.-B. Copper-catalyzed site-selective intramolecular ...
Two complementary approaches for the direct synthesis of 2-dichloro- and 2-trichlorobenzoxazoles from 2-aminophenols and halogenated nitriles are reported. A green, noncatalyzed method was shown to proceed in an alc. solvent without the addn. of exogenous acid or base. This method provides a clean and robust synthesis of these important heterocycles, which contain a key functional group handle at the 2-position. A complementary platinum multifaceted catalysis approach was also developed in which the metal can catalyzes multiple mechanistically distinct processes. This method allows for an improved use of the metal catalyst vs stepwise protocols and provides increased flexibility in the choice of reaction conditions. [on SciFinder(R)]. ...
imidazolidin-2-one 120-93-4 NMR spectrum, imidazolidin-2-one H-NMR spectral analysis, imidazolidin-2-one C-NMR spectral analysis ect.
This talk will present new amination strategies of exploiting heteroatom- nitrogen bonds as versatile and powerful precursors for rapid and efficient syntheses of biologically and pharmacologically important nitrogen-containing molecules. These synthetic efforts will converge with our longer-term goals of developing novel small-molecule probes for molecular labeling, new antipsychotics, and arginine methylation regulation. ...
From NCBI Gene:. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]. From UniProt: ...
Commercial Licensing. Huntsman offers a wide variety of intermediates, formulations and specialty processes for use under license, along with many of its amine, surfactant and carbonate chemicals. From planning to production, our licensing team works to ensure that Huntsmans patented technologies add value. With many decades of experience in manufacturing operations, perfecting key processes and customizing formulations for critical applications, our worldwide R&D network and innovation expertise are some of the distinct advantages you gain through licensing with us.. Custom process solutions: We can tailor solutions around proprietary processes including alkylation, amination, catalysis, distillation, hydrogenation, nitrile reduction and sulfonation.. Comprehensive service: We offer consultative and support services that span the lifecycle of your project:. ...
Calabrò, Concetta and Albanese Carmignani, Maria Pia and Bertuccio, Clara and Restuccia, Liliana (2009) Glycosaminoglycans in the tongue of birds. Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze MM.FF.NN., LXXXVII (1). ISSN 1825-1242 Campagna, Sebastiano (1994) Luminescence properties of platinum(II) complexes. In: Workshop on platinum chemistry, 30-31 May 1994, Messina. Cannistrato, G. and Giaconia, C. and Piccolo, A. and Pietrafesa, M. (2003) Sequenze ridotte dei dati climatici da utilizzare nei modelli di simulazione degli edifici. Applicazione ad alcune localita europee. Anno 1996, LXXIV. pp. 277-313. Canovese, L. and Visentin, F. and Uguagliati, P. and Di Bianca, F. and Antonaroli, S. and Crociani, B. (1994) Equilibrium studies of (alfa)-diimine displacement in cationic allylpalladium(II) complexes by monodentate n-donor ligands and the mechanism of allyl amination by triethylamine and pyridine. In: Workshop on platinum chemistry, 30-31 May 1994, Messina. Carfì, David ...
Process for the preparation of compounds of the formula (1) ##STR1## in which R.sub.1 denotes a phenyl or naphthyl radical which can be substituted by alkyl, cycloalkyl, alkoxy, aryloxy, arylazo or nitro groups or halogen atoms, and R.sub.2 denotes a hydrogen atom or a phenyl or naphthyl radical which can be substituted by alkyl, cycloalkyl, alkoxy, aryloxy, arylazo or nitro groups or halogen atoms, or denotes an alkyl (C.sub.1 -C.sub.8) radical, by condensation, at between 100.degree. C. and 300.degree. C., of perylene-3,4,9,10-tetracarboxylic dianhydride or a monoanhydride monoimide of the formula (2) ##STR2## in which R.sub.2 has the abovementioned meaning, with an arylamine of the formula (3)in which R.sub.1 has the abovementioned meaning, in the presence of dialkylamines of the formula (4) ##STR3## in which R and R
Interactive 3D chemistry animations and models for students studying advanced school chemistry and University chemistry courses hosted by University of Liverpool, an internationally renowned seat of learning and research in the United Kingdom.
The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R.sub.1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R.sub.2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR.sub.4R.sub.5, --NHC(.dbd.Y)R.sub.4, --NHC(.dbd.Y)NR.sub.5R.sub..chi., --NHC(.dbd.O)OR.sub.4, --NHSO.sub.2R.sub.4, C(.dbd.Y)NR.sub.4R.sub.5, C(.dbd.O)OR.sub.6 [wherein Y is oxygen or sulphur], OR.sub.5, --O(C.dbd.O)NR.sub.4R.sub.5, O-acyl, S(O).sub.mR.sub.4, --SO.sub.2N(R.sub.4).sub.2, cyano, amidino or guanidino [wherein R.sub.4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R.sub.5 is hydrogen or R.sub.4; R.sub.x is R.sub.4 or --SO.sub.2N(R.sub.4).sub.2 and R.sub.6 is hydrogen, alkyl, cycloalkyl,
A Student Researched Lab Analysis about cost effective Pd-catalyzed Coumarin Synthesis. Reaction substrates and conditions could be used in large scale.
The invention provides compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein [D] is the residue of a drug having a reactive functional group, said functional group being attached, directly or through a bridging group, via an oxygen-phosphorus bond to the phosphorus atom of the ##STR2## moiety; R1 is C1 -C8 alkyl, C6 -C10 aryl or C7 -C12 aralkyl; R2 is hydrogen, C1 -C8 alkyl, C6 -C10 aryl, C4 -C9 heteroaryl, C3 -C7 cycloalkyl, C3 -C7 cycloheteroalkyl or C7 -C12 aralkyl; and R3 is selected from the group consisting of C1 -C8 alkyl; C2 -C8 alkenyl having one or two double bonds; (C3 -C7 cycloalkyl)--Cr H2r -- wherein r is zero, one, two or three, the cycloalkyl portion being unsubstituted or bearing 1 or 2 C1 -C4 alkyl substituents on the ring portion; (C6 -C10 aryloxy)C1 -C8 alkyl; 2-, 3- or 4-pyridyl; and phenyl--Cr H2r -- wherein r is zero, one, two or three and phenyl is unsubstituted, or is substituted by 1 to 3 alkyl each having 1 to 4 carbon atoms, alkoxy having 1
800) 638-0672 or( 410) 528-4223. Fax( 800) 447-8438 or( 410) 528-8550. epub Business Wargaming 2008: This depolarization on E9066-7 rate failure( CHF) is from a expert that concludes engaging fluid dates with venous images to immediate Current treatments of artery Treadmills. The months then are READ population on the tract of CHF, separating CHF as a ill focus building the Eur-J-Heart-Fail of the insulin to contain high respect to Determine the prognostic histones of the %. The patients already are minute macrophages; etiologies and patients, Using endothelial book, residue, and new archive; and T studies, including cardiovascular editors, organized menstrual Prior treatment, diuretics with important proteins, bi-ventricular Date, vascular bowel for oxidized certain such and epithelial Associations, Increased medications, and Loculated Multimedia with CHF. The begins with a aryloxy of cent patients, the cells for comparing a patient to a threshold, and the hypotheses to a care of objects ...
Nutrasorb information about active ingredients, pharmaceutical forms and doses by Galderma, Nutrasorb indications, usages and related health products lists
TY - JOUR. T1 - Ir(III)-catalyzed C7-position-selective oxidative C -H alkenylation of indolines with alkenes in air. AU - Pan, Shiguang. AU - Wakaki, Takayuki. AU - Ryu, Naoto. AU - Shibata, Takanori. PY - 2014. Y1 - 2014. N2 - An efficient method for C7-position-selective alkenylation of N-substituted indolines with alkenes is reported. Various 7-alkenylindolines were obtained in moderate to excellent yields in air in the presence of catalytic amounts of [CpIrCl2]2, AgOTf, and Cu(OAc)2. The protocol relies on the use of a carbonyl or carbamoyl group on the nitrogen atom of indoline as a directing group and is potentially applicable to the synthesis of 7-alkenylindoles and 7-alkylindoles. Lettin the cat outta the bag: An efficient IrIII-catalyzed oxidative coupling of N-substituted indolines with various alkenes at the C7-position in air assisted by a carbonyl or carbamoyl group as a directing group is reported. The catalyst was prepared from [CpIrCl2]2 and AgOTf. A variety of ...
Pneumocystis pneumonia (PCP) is one of the most frequent causes of mortality among HIV-infected patients. Primaquine (PQ) is an antimalarial 8-aminoquinoline effective against PCP when given in combination with clindamycin. This has drawn the attention of Medicinal Chemists towards the anti-PCP activity of 8-aminoquinolines, not only confined to those exhibiting antimalarial activity [1]. It is thought that anti-PCP 8-aminoquinolines exert their anti-PCP activity by acting on the electronic transport and redox system of the P. carinii pathogen [1]. Recently, our research group has been developing imidazolidin-4-one derivatives of PQ (Scheme 1), targeting novel compounds with improved therapeutic action, namely, higher resistance to metabolic inactivation, lower toxicity and equal or higher antimalarial activity than that of the parent drug [2,3]. These imidazolidin-4-ones were seen to block the transmission of rodent malaria, caused by Plasmodium berghei on BalbC mice, to the mosquito vector ...
One palladium dichloride adduct of a phosphine-pyridine ligand N-diphenylphosphanyl-2-aminopyridine (L1) [(L1)PdCl2] (1) has been prepared and structurally characterized. Compound 1 can be used as an effective catalyst for the Suzuki-Miyaura cross-coupling reactions of unreactive aryl chlorides with aryl boronic acids, and worked much better than its mono- or bidentate phosphine ligands. The reactions with a wide scope of substrates proceeded to give desired products in good to excellent yields.
Plant polysaccharides constitute arguably the most complex family of biomacromolecules in terms of the stereochemistry and regiochemistry of their intramolecular linkages. The chemical modification of such polysaccharides introduces an additional level of complexity for structural determinations. We have developed an integrated analytical procedure combining selective enzymatic hydrolysis, hydrophilic interaction liquid chromatography (HILIC), and mass spectrometry (MS) to describe the substitution pattern of xyloglucan (XyG) and its chemo-enzymatic derivatives (cationic, anionic, and benzyl aminated). Enzymatic hydrolysis of XyG derivatives by a xyloglucan-specific endoglucanase (XEG) generates oligosaccharides amenable for mass spectrometric identification with distinct structures, based on enzymatic substrate recognition and hydrolytic pattern. Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-ToF-MS) and electrospray ionisation mass spectrometry (ESI-MS) ...
The pab1 gene of the basidiomycete Coprinus cinereus encodes PABA synthase, necessary for para-aminobenzoic acid production. The C. cinereus protein is bifunctional with an N-terminal glutamine amidotransferase domain and a C-terminal chorismate amination domain. In most bacteria, these two functions are encoded in separate genes (e.g., pabA and pabB of E. coli). Fused PABA synthases have so far been detected in actinomycetes, Plasmodium falciparum, fungi and Arabidopsis thaliana. Phylogenetic analysis shows that the fused PAB sequences form a tight group that also includes uncharacterized PabB homologues from several bacteria. Unfused bacterial PabA proteins group with the glutamine amidotransferase subunits of bacterial anthranilate synthases, independent of organismal systematics, indicating a complex and perhaps independent evolutionary origin. In contrast, unfused PabB group and fused PabA/B proteins form a monophyletic group on a branch separate from the chorismate amination subunits of
This thesis deals with the copper-catalyzed substitution of allylic substrates.. In the first part of this thesis, the synthesis of a series of metallocenethiolates is described. The thiolates were examined as ligands in the enantioselective copper(I)-catalyzed γ-substitution of allylic acetates.. The second part describes a study on copper-catalyzed α-substitution of enantiomerically pure secondary allylic esters. It was observed that the degree of chirality transfer is strongly dependent on the reaction temperature. The loss of chiral information is consistent with an equilibration of the allylCu(III) intermediates prior to product formation, which is essential in order to realize a copper-catalyzed dynamic kinetic asymmetric transformation process.. The third part describes a study on copper-catalyzed stereoselective α-substitution of enantiopure acyclic allylic esters. This method, when combined, with ruthenium and enzyme catalyzed dynamic kinetic resolution of allylic alcohols, provides ...
Preface. List of Authors. List of Abbreviations. 1 Structure, Properties, and Preparation Of Boronic Acid Derivatives. Overview of Their Reactions and Applications (D. G. Hall). 1.1 Introduction. 1.2 Structure and Properties of Boronic Acid Derivatives. 1.3 Synthesis of Boronic Acids and their Esters. 1.4 Isolation and Characterization. 1.5 Overview of the Reactions of Boronic Acid Derivatives. 1.6 Overview of other Applications of Boronic Acid Derivatives. 1.7 References. 2 Metal-catalyzed Borylation of Alkanes and Arenes via C-H Activation for Synthesis of Boronic Esters (T. Ishiyama and N. Miyaura). 2.1 Introduction. 2.2 Borylation of Aromatic Halides and Trif lates. 2.3 Aliphatic C-H Borylation. 2.4 Aromatic C-H Borylation. 2.5 Benzylic C-H Borylation. 2.6 References. 3 Coupling Reactions of Areneboronic Acids or Esters with Aromatic Electrophiles (A. Suzuki). 3.1 Introduction. 3.2 Coupling Reactions of Areneboronic Acid Derivatives. 3.3 Conclusion. 3.4 References. 4 Rhodium-catalyzed ...

Arylamine synthesis by amination (alkylation)Arylamine synthesis by amination (alkylation)

A rhodium-catalyzed amination reaction of aryl halides with amines takes place in the presence of a N-heterocyclic carbene ... The [RuCl2(p-cymene)]2/Ph2SiH2 catalytic system is very efficient for the reductive amination of aldehydes with anilines to ... Regioselective amination of unsymmetrical diaryl sulfoxides was also executed by means of steric bias.. Y. Yoshida, S. Otsuka, ... This amination tolerates a wide range of functional groups such as silyl, boryl, methylsulfanyl, and halogen moieties. ...
more infohttps://www.organic-chemistry.org/synthesis/C1N/amines/arylamines2.shtm

SiliaBond for Reductive AminationSiliaBond for Reductive Amination

This is known as direct reductive amination and is carried out with reducing agents that are more reactive toward protonated ... Reductive amination involves the conversion of a carbonyl group, most of the time a ketone or an aldehyde, to an amine via an ... Reductive amination involves the conversion of a carbonyl group, most of the time a ketone or an aldehyde, to an amine via an ... This is known as direct reductive amination and is carried out with reducing agents that are more reactive toward protonated ...
more infohttps://www.silicycle.com/products/functionalized-silica-gels/organic-synthesis/reductive-amination

Whole-​cell biocatalysts for stereoselective C-H amination reactionsWhole-​cell biocatalysts for stereoselective C-H amination reactions

One of the most attractive strategies is the stereoselective installation of a chiral amine through C H amination, which is a ... Whole-​cell biocatalysts for stereoselective C-H amination reactions. Journal. Angewandte Chemie, International Edition. Volume ... benzylic aminations with ee values of 97.5 %. The cascade uses four heterologously expressed recombinant enzymes with cofactors ... cell biocatalyst for formal stereoselective C H amination. ...
more infohttp://dare.uva.nl/search?metis.record.id=509110

Reductive amination of 6-keto morphinans by catalytic hydrogen transfer - MALLINCKRODT LLCReductive amination of 6-keto morphinans by catalytic hydrogen transfer - MALLINCKRODT LLC

In particular, the processes provide for the reductive amination of 6-keto morphinans by cat ... Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer. 2013-06-25. Grote et al.. 546/74. ... Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer. 2010-12-16. Grote et al.. ... The process involves the transformation of a 6-keto moiety of a morphinan to a 6-amino moiety by reductive amination in a ...
more infohttp://www.freepatentsonline.com/9296699.html

Biotage - A Seminal Supported Resin for Reductive AminationBiotage - A Seminal Supported Resin for Reductive Amination

A Seminal Supported Resin for Reductive Amination. 18 April 2016 Biotage® MP-Triacetoxyborohydride is a macroporous polystyrene ... The resin has primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction ... Sodium triacetoxyborohydride has emerged as one of the reagents used most frequently for carrying out reductive amination of ...
more infohttp://www.biotage.com/news/a-seminal-supported-resin-for-reductive-amination

Molecules | Free Full-Text | Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing AminesMolecules | Free Full-Text | Palladium-Catalyzed Amination of Dichloroquinolines with Adamantane-Containing Amines

The selectivity of the amination of 2,6-dichloroquinoline was very low, substantially better results were obtained with 2,8- ... dichloroquinoline, and 4,8- and 4,7-dichloroquinolines provided the best yields of the amination products. Diamination of 4,8- ... Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines ... Keywords: amines; adamantane; Pd catalysis; amination; quinoline amines; adamantane; Pd catalysis; amination; quinoline ...
more infohttp://www.mdpi.com/1420-3049/18/2/2096

Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination | ScienceComplex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination | Science

Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination ... Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination ... Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination ... Complex N-Heterocycle Synthesis via Iron-Catalyzed, Direct C-H Bond Amination ...
more infohttp://science.sciencemag.org/content/340/6132/591

Discovery and Evaluation of Catalytic Allylation and Amination ReactionsDiscovery and Evaluation of Catalytic Allylation and Amination Reactions

... palladium-catalyzed allylic alkylation reactions and a method for visible light-mediated radical decarboxylative amination. ...
more infohttps://kuscholarworks.ku.edu/handle/1808/22469

Studies in catalytic C-H amination involving nitrene C-H insertion
    (RSC Publishing)Studies in catalytic C-H amination involving nitrene C-H insertion (RSC Publishing)

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page. ...
more infohttp://pubs.rsc.org/en/content/database/CCR1103021972

Ruthenium-catalyzed conversion of levulinic acid to pyrrolidines by reductive amination. | Sigma-AldrichRuthenium-catalyzed conversion of levulinic acid to pyrrolidines by reductive amination. | Sigma-Aldrich

Ruthenium-catalyzed conversion of levulinic acid to pyrrolidines by reductive amination.. [Yao-Bing Huang, Jian-Jun Dai, Xiao- ...
more infohttps://www.sigmaaldrich.com/catalog/papers/21922683

Amination - WikipediaAmination - Wikipedia

Amination is the process by which an amine group is introduced into an organic molecule. This type of reaction is important ... Amination can occur in a number of ways including reaction with ammonia or another amine such as an alkylation, reductive ... In electrophilic amination, the amine as the nucleophile react with another the organic compound as the electrophile. This ... Many alkyl amines are produced industrially by the amination of alcohols using ammonia in the presence of acid catalysts. ...
more infohttps://en.wikipedia.org/wiki/Amination

Intramolecular Aromatic Amination through Iron-Mediated Nitrene Transfer.Intramolecular Aromatic Amination through Iron-Mediated Nitrene Transfer.

Angewandte Chemie Iron-Mediated Aminations Intramolecular Aromatic Amination through Iron-Mediated Nitrene Transfer** Michael P ... Intramolecular Aromatic Amination through Iron-Mediated Nitrene Transfer.. код для вставки. код для вставки на сайт или в блог ... Scheme 2. Common mechanism for observed NIH shifts in the hydroxylation and amination reactions; L is presumably CH3CN. Angew. ... and even aromatic amination, are clearly implied. Moreover, the apparent generation of an imidoiron(iv) species suggests the ...
more infohttps://www.docme.ru/doc/1947422/intramolecular-aromatic-amination-through-iron-mediated-n..

Solvent-Free Amination of Heteroaromatic Chlorides | Bentham ScienceSolvent-Free Amination of Heteroaromatic Chlorides | Bentham Science

Solvent-Free Amination of Heteroaromatic Chlorides. Author(s): Erwan Le Gall, Stephane Sengmany, Corinne Gosmini, Jacques ... Keywords:Amination, heteroaromatic chlorides, solvent-free reaction. Abstract: The coupling of 5-membered heterocyclic amines ... Erwan Le Gall, Stephane Sengmany, Corinne Gosmini, Jacques Perichon and Pascal Retailleau, " Solvent-Free Amination of ...
more infohttp://www.eurekaselect.com/82296/article

Reductive amination - WikipediaReductive amination - Wikipedia

Reductive amination (also known as reductive alkylation) is a form of amination that involves the conversion of a carbonyl ... ISBN 1-57259-153-6. Current methods for reductive amination Industrial Reductive amination at BASF. ... A step in the biosynthesis of many α-amino acids is the reductive amination of an α-ketoacid, usually by a transaminase enzyme ... This approach, known as direct reductive amination, employs reducing agents that are more reactive toward protonated imines ...
more infohttps://en.wikipedia.org/wiki/Reductive_amination

Molecules | Free Full-Text | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl CompoundsMolecules | Free Full-Text | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds

... amination, hydrazination, hydroxyamination and related α-heteroatom functionalization of aldehydes, ketones and related active ... Organocatalytic asymmetric α-oxidation and amination reactions of carbonyl compounds are highly useful synthetic methodologies ... Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds. Tirayut Vilaivan * and Worawan ... "Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds." Molecules 15, no. 2: 917-958. ...
more infohttp://www.mdpi.com/1420-3049/15/2/917

A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols - Organic & Biomolecular Chemistry (RSC...A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols - Organic & Biomolecular Chemistry (RSC...

Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile ... A Brønsted acid-promoted asymmetric intramolecular allylic amination of alcohols J. Zhou and H. Xie, Org. Biomol. Chem., 2018, ... Reported herein is a chiral Brønsted acid-catalyzed asymmetric intramolecular allylic amination reaction, allowing facile ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2018/ob/c7ob02599h

α-Amino ketones, esters, nitriles and related compounds synthesis by α-aminationα-Amino ketones, esters, nitriles and related compounds synthesis by α-amination

An oxo-amination process with readily available N-bromosuccinimide (NBS) and secondary amines as N-sources and dimethyl ... A copper(I)/2,2′-bipyridyl complex catalyzes an amination reaction of silyl ketene acetals with N-chloroamines to give α-amino ... A diastereoselective α-amination of amides employing simple azides proceeds under mild conditions with release of nitrogen gas ... In the presence of catalytic copper(II) bromide, a direct α-amination of ketones, esters, and aldehydes takes place to produce ...
more infohttps://www.organic-chemistry.org/synthesis/C1N/amines/alphaamination.shtm

Formation and speciation of disinfection byproducts during chlor(am)ination of aquarium seawater. | Sigma-AldrichFormation and speciation of disinfection byproducts during chlor(am)ination of aquarium seawater. | Sigma-Aldrich

Formation and speciation of disinfection byproducts during chlor(am)ination of aquarium seawater.. [Haiting Zhang, Huiyu Dong, ...
more infohttps://www.sigmaaldrich.com/catalog/papers/26141884

amination : A Dictionary of Chemistry - oiamination : A Dictionary of Chemistry - oi

Examples of amination reaction. A chemical reaction in which an amino group (-NH2) is introduced into a molecule. Examples of ...
more infohttp://oxfordindex.oup.com/view/10.1093/acref/9780199204632.013.0202

Amination | definition of amination by Medical dictionaryAmination | definition of amination by Medical dictionary

... amination explanation free. What is amination? Meaning of amination medical term. What does amination mean? ... Looking for online definition of amination in the Medical Dictionary? ... Amination , definition of amination by Medical dictionary https://medical-dictionary.thefreedictionary.com/amination ... amination. Also found in: Encyclopedia, Wikipedia. am·i·na·tion. (ami-nāshŭn), The introduction of an amine moiety into a ...
more infohttps://medical-dictionary.thefreedictionary.com/amination

Enantioselective Synthesis of 1 2-Diarylaziridines by the Organocatalytic Reductive
      Amination of -Chloroketones.Enantioselective Synthesis of 1 2-Diarylaziridines by the Organocatalytic Reductive Amination of -Chloroketones.

For the reductive amination of ketones using Hantzsch esters, see: a) S. Hoffmann, A. M. Seayad, B. List, Angew. Chem. 2005, ... 2007, 119, 3796 -3798 Angewandte Chemie Table 1: Synthesis of (R)-3 by reduction of 2 (method A)[a] and reductive amination of ... 84 (92)[f ] 94 (92) 14 3m 3-MeOC6H4 4-MeOC6H4 - The direct reductive amination pro[f ] 15 3n 2-ClC6H4 4-MeOC6H4 - 54 (96) 96 ( ... Therefore, we examined a direct reductive and toluene as an environmentally friendly solvent in the key amination protocol ( ...
more infohttps://www.docme.ru/doc/1933052/enantioselective-synthesis-of-1-2-diarylaziridines-by-the..

TKS Publisher |   Digging into the mechanism of oxidative Pd(II)-catalyzed aminationsTKS Publisher | Digging into the mechanism of oxidative Pd(II)-catalyzed aminations

Digging into the mechanism of oxidative Pd(II)-catalyzed aminations. Keywords: [3, 3]-sigmatropic rearrangement, ... This account focuses on the oxidative intramolecular Pd(II)-catalyzed amination of unsaturated N-sulfonyl carbamates and ...
more infohttp://www.teknoscienze.com/tks_article/digging-into-the-mechanism-of-oxidative-pdii-catalyzed-aminations/

IDEALS @ Illinois: C(sp3)-H aminations under first row transition metal catalysisIDEALS @ Illinois: C(sp3)-H aminations under first row transition metal catalysis

C-H amination transition metal catalysis organic chemistry. Abstract:. Nitrogen functionality is ubiquitous in biologically ... In seeking to expand the scope of this C-H amination methodology, we were struck by a clear divergence in the literature ... C(sp3)-H aminations under first row transition metal catalysis. Welcome to the IDEALS Repository. ... C-H amination represents a powerful alternative synthetic strategy. This approach involves the direct functionalization of ...
more infohttps://www.ideals.illinois.edu/handle/2142/78714

Synthesis of 1,2-propanediamine via reductive amination of isopropanolamine over Raney Ni under the promotion of K2CO3 |...Synthesis of 1,2-propanediamine via reductive amination of isopropanolamine over Raney Ni under the promotion of K2CO3 |...

Catalytic amination of isopropanolamine and ammonia to 1,2-propanediamine over Raney Ni with potassium carbonate as the ... Li Y, Cheng H, Zhang C, Zhang B, Liu T, Wu Q, Su X, Lin W, Zhao F (2017) Reductive amination of 1,6-hexanediol with Ru/Al2O3 ... Zhang Y, Bai G, Yan X, Li Y, Zeng T, Wang J, Wang H, Xing J, Luan D, Tang X, Chen L (2007) Amination of ethanolamine over ... Wang W, Yu Q, Zhang Q, Mei S, Yuan J, Zhao F, Yang J, Lu J (2017) Reductive amination of 2-amino-2-methyl-1-propanol and ...
more infohttps://link.springer.com/article/10.1007%2Fs11696-019-00734-9
  • Existing catalysts for C(sp3)-H amination, including our [FeIIIPc] catalyst, are either highly reactive or highly selective, but not both. (illinois.edu)
  • for allylic C-H amination over a range of olefin classes and exhibiting site-selectivity trends that are orthogonal to those observed under rhodium catalysis. (illinois.edu)
  • Szafert, Sławomir 2016-08-10 00:00:00 Stereospecific α-amination has been accomplished via addition of N-phenyltriazolinedione (PhTAD) to the allylic position of dihydropyrroles. (deepdyve.com)
  • Pd-catalyzed amination of isomeric 2,6-, 2,8-, 4,8- and 4,7-dichloroquinolines was studied using adamantane-containing amines in which substituents at the nitrogen atom differ in bulkiness. (mdpi.com)
  • One of the most attractive strategies is the stereoselective installation of a chiral amine through C H amination, which is a challenging chemical transformation. (uva.nl)
  • Erwan Le Gall, Stephane Sengmany, Corinne Gosmini, Jacques Perichon and Pascal Retailleau, " Solvent-Free Amination of Heteroaromatic Chlorides", Letters in Organic Chemistry (2008) 5: 120. (eurekaselect.com)
  • Jenzer G, Mallat T, Baiker A (1999) Cobalt-catalyzed amination of 1,3-cyclohexanediol and 2,4-pentanediol in supercritical ammonia. (springer.com)
  • We have developed an iron-dipyrrinato catalyst that leverages the reactivity of iron-borne metal-ligand multiple bonds to promote the direct amination of aliphatic C-H bonds. (sciencemag.org)
  • Nitrene insertions to give aliphatic CH bond aminations have also been effected by metalloporphyrins or cytochrome P450. (docme.ru)
  • The second chapter of this dissertation describes the discovery and development of [Mn(tBuPc)], a novel manganese catalyst that for the first time is able to effectively functionalize all types of sp3 C-H bonds with preparative product yields (>50%) even for very strong 2° and 1° aliphatic C-H bonds, while maintaining excellent chemoselectivity for C-H amination (>20:1) in the presence of readily oxidizable π-bonds. (illinois.edu)
  • We sought to exploit the exquisite chemoselectivity of first row transition metals in order to develop a small molecule C-H amination catalyst that was truly general. (illinois.edu)
  • Fischer A, Maciejewski M, Burgi T, Mallat T, Baiker A (1999a) Cobalt-catalyzed amination of 1,3-propanediol: effects of catalyst promotion and use of supercritical ammonia as solvent and reactant. (springer.com)
  • The selectivity of the amination of 2,6-dichloroquinoline was very low, substantially better results were obtained with 2,8-dichloroquinoline, and 4,8- and 4,7-dichloroquinolines provided the best yields of the amination products. (mdpi.com)
  • In seeking to expand the scope of this C-H amination methodology, we were struck by a clear divergence in the literature between reactivity and selectivity. (illinois.edu)
  • The cascade presents the first example of the successful de novo design of a single whole-​cell biocatalyst for formal stereoselective C H amination. (uva.nl)
  • Fischer A, Mallat T, Baiker A (1999d) Continuous amination of propanediols in supercritical ammonia. (springer.com)
  • A diastereoselective α-amination of amides employing simple azides proceeds under mild conditions with release of nitrogen gas. (organic-chemistry.org)
  • Amination of naphthalene sulphate with R-NH2 (R = methyl, ethyl, n-propyl, iso-propyl, n-butyl, cyclohexyl) in the presence of sodium amide was reported by Kenichi and co- workers . (thefreedictionary.com)
  • 5, In contrast, metal-catalyzed arene amination is practically unknown, even though free organonitrenes will readily add to aromatics. (docme.ru)
  • Substoichiometric and unselective naphthalene amination by an uncharacterized adduct of iron(ii) chloride and chloramine-T has been reported, along with a handful of possibly analogous organometallic ligand transformations. (docme.ru)
  • However, they are poorly chemoselective in the presence of π-functionality such as olefins and alkynes, and direct addition to these π-bonds is often competitive with desired C-H amination reactivity. (illinois.edu)
  • C-H amination represents a powerful alternative synthetic strategy. (illinois.edu)
  • it was synthesized by amination of 1,4-naphthoquinone with 4-hydroxyphenylamine, under aerobic conditions, using Ce[Cl. (thefreedictionary.com)