Amination
Palladium
Amines
Rhodium
Hydrocarbons, Acyclic
Alkenes
Molecular Structure
Stereoisomerism
Catalysis
Alanine Dehydrogenase
An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMONIA. The enzyme is needed for growth when ALANINE is the sole CARBON or NITROGEN source. It may also play a role in CELL WALL synthesis because L-ALANINE is an important constituent of the PEPTIDOGLYCAN layer.
Lycopodium
Physicochemical Processes
Glutamate Dehydrogenase
Phosphines
Aziridines
Green Chemistry Technology
Cyclization
Amino Acid Oxidoreductases
Reaction specificity of native and nicked 3,4-dihydroxyphenylalanine decarboxylase. (1/218)
3,4-Dihydroxyphenylalanine (Dopa) decarboxylase is a stereospecific pyridoxal 5'-phosphate (PLP)-dependent alpha-decarboxylase that converts L-aromatic amino acids into their corresponding amines. We now report that reaction of the enzyme with D-5-hydroxytryptophan or D-Dopa results in a time-dependent inactivation and conversion of the PLP coenzyme to pyridoxamine 5'-phosphate and PLP-D-amino acid Pictet-Spengler adducts, which have been identified by high performance liquid chromatography. We also show that the reaction specificity of Dopa decarboxylase toward aromatic amines depends on the experimental conditions. Whereas oxidative deamination occurs under aerobic conditions (Bertoldi, M., Moore, P. S., Maras, B., Dominici, P., and Borri Voltattorni, C. (1996) J. Biol. Chem. 271, 23954-23959; Bertoldi, M., Dominici, P., Moore, P. S., Maras, B., and Borri Voltattorni, C. (1998) Biochemistry 37, 6552-6561), half-transamination and Pictet-Spengler reactions take place under anaerobic conditions. Moreover, we examined the reaction specificity of nicked Dopa decarboxylase, obtained by selective tryptic cleavage of the native enzyme between Lys334 and His335. Although this enzymatic species does not exhibit either decarboxylase or oxidative deamination activities, it retains a large percentage of the native transaminase activity toward D-aromatic amino acids and displays a slow transaminase activity toward aromatic amines. These transamination reactions occur concomitantly with the formation of cyclic coenzyme-substrate adducts. Together with additional data, we thus suggest that native Dopa decarboxylase can exist as an equilibrium among "open," "half-open," and "closed" forms. (+info)Effect of the ratio between essential and nonessential amino acids in the diet on utilization of nitrogen and amino acids by growing pigs. (2/218)
In 36 growing pigs (30 to 60 kg), N balance and amino acid (AA) composition of weight gain were measured to evaluate the interactive effect of the ratio between N from essential amino acids (EAA(N)) to nonessential amino acids (NEAA(N)) and total N level (T(N)) in the diet on N retention and utilization of N, EAA(N), NEAA(N), and AA. Nine diets composed from ordinary feedstuffs and supplemented with crystalline AA were used (three EAA(N):NEAA(N) ratios of 38:62, 50:50, and 62:38 at three T(N) levels of 18.8, 22.9, and 30.0 g/kg). Pigs were fed restrictedly, at a level of 2.8 x energy for maintenance. In all diets, EAA (including arginine) supply was according to or slightly above the recommended ratios to lysine. Measurements were done in four blocks of nine pigs each. In a concomitant slaughter experiment, the AA composition of deposited body protein was determined to estimate AA utilization. The effects of T(N) and EAA(N):NEAA(N) and their interaction for N retention and utilization were significant. Nitrogen retention increased with higher T(N) in the diet. Increasing EAA(N):NEAA(N) from 38:62 to 50:50 improved N retention only at the two lower T(N) levels. Increasing EAA(N): NEAA(N) above 50:50 failed to improve N retention significantly at any of the three T(N) levels. Lowering T(N) improved the utilization of total and digested N and of EAA(N) and NEAA(N). The increase in EAA(N): NEAA(N) consistently resulted in a lower utilization of EAA(N), but this was compensated by a higher utilization of NEAA(N). The utilization of T(N) was improved by increasing EAA(N):NEAA(N) from 38:62 to 50:50 at the two lower T(N) levels and was relatively unaffected by EAA(N):NEAA(N) at the highest T(N). However, a lower utilization of N was observed at a ratio of 62:38 at a T(N) level of 22.9 g/kg. The effects were similar for utilization of individual EAA and NEAA. Utilization of alanine, aspartic acid, and glycine was close to or >100% at the highest EAA(N):NEAA(N), which was expected because all of these AA are synthesized in pigs. Also, the utilization of arginine was >100% in most of the treatments, which confirms the semiessential character of this AA for maintenance. We concluded that the required ratio of EAA(N):NEAA(N) for optimal N retention and utilization is approximately 50:50. The EAA(N):NEAA(N) is more important at lower dietary protein levels. This study indicates that EAA(N): NEAA(N) can be increased up to 70:30 without lowering the utilization of N. Thus, deaminated EAA(N) was efficiently utilized for the synthesis of NEAA(N). (+info)Effects of branched-chain-enriched amino acids and insulin on forearm leucine kinetics. (3/218)
Although amino acid mixtures enriched in branched-chain amino acids (BCAA) and deficient in aromatic amino acids (AAA) are often used together with insulin and glucose in clinical nutrition, their physiological effects on muscle protein anabolism are not known. To this aim, we studied forearm leucine kinetics in post-absorptive volunteers, before and after the systemic infusion of BCAA-enriched, AAA-deficient amino acids along with insulin and the euglycaemic clamp. The results were compared with the effects of insulin infusion alone. A compartmental leucine forearm model was employed at steady state. Hyperaminoacidaemia with hyperinsulinaemia (to approximately 80-100 micro-units/ml) increased the leucine plasma concentration (+70%; P<0.001), inflow into the forearm cell (+150%; P<0.01), disposal into protein synthesis (+100%; P<0.01), net intracellular retention (P<0.01), net forearm balance (by approximately 6-fold; P<0.01) and net deamination to alpha-ketoisocaproate (4-methyl-2-oxopentanoate) (+9%; P<0.05). Leucine release from forearm proteolysis and outflow from the forearm cell were unchanged. In contrast, hyperinsulinaemia alone decreased plasma leucine concentrations (-35%; P<0.001) and leucine inflow (-20%; P<0.05) and outflow (-30%; P<0.01) into and out of forearm cell(s), it increased net intracellular leucine retention (P<0.03), and it did not change leucine release from forearm proteolysis (-20%; P=0.138), net leucine deamination to alpha-ketoisocaproate, leucine disposal into protein synthesis or net forearm protein balance. By considering all data together, leucine disposal into protein synthesis was directly correlated with leucine inflow into the cell (r=0.71; P<0.0001). These data indicate that the infusion of BCAA-enriched, AAA-deficient amino acids along with insulin is capable of stimulating forearm (i.e. muscle) protein anabolism in normal volunteers by enhancing intracellular leucine transport and protein synthesis. These effects are probably due to hyperaminoacidaemia and/or its interaction with hyperinsulinaemia, since they were not observed under conditions of hyperinsulinaemia alone. (+info)Fluorescent neoglycolipids. Improved probes for oligosaccharide ligand discovery. (4/218)
A second generation of lipid-linked oligosaccharide probes, fluorescent neoglycolipids, has been designed and synthesized for ligand discovery within highly complex mixtures of oligosaccharides. The aminolipid 1,2-dihexadecyl-sn-glycero-3-phosphoethanolamine (DHPE), which has been used extensively to generate neoglycolipids for biological and structural studies, has been modified to incorporate a fluorescent label, anthracene. This new lipid reagent, N-aminoacetyl-N-(9-anthracenylmethyl)-1, 2-dihexadecyl-sn-glycero-3-phosphoethanolamine (ADHP), synthesized from anthracenaldehyde and DHPE gives an intense fluorescence under UV light. Fluorescent neoglycolipids derived from a variety of neutral and acidic oligosaccharides by conjugation to ADHP, by reductive amination, can be detected and quantified by spectrophotometry and scanning densitometry, and resolved by TLC and HPLC with subpicomole detection. Antigenicities of the ADHP-neoglycolipids are well retained, and picomole levels can be detected using monoclonal carbohydrate sequence-specific antibodies. Among O-glycans from an ovarian cystadenoma mucin, isomeric oligosaccharide sequences, sialyl-Lea- and sialyl-Lex-active, could be resolved by HPLC as fluorescent neoglycolipids, and sequenced by liquid secondary-ion mass spectrometry. Thus the neoglycolipid technology now uniquely combines high sensitivity of immuno-detection with a comparable sensitivity of chemical detection. Principles are thus established for a streamlined technology whereby an oligosaccharide population is carried through ligand detection and ligand isolation steps, and sequence determination by mass spectrometry, enzymatic sequencing and other state-of-the-art technologies for carbohydrate analysis. (+info)Structure of the Bordetella pertussis 1414 endotoxin. (5/218)
The endotoxin (lipopolysaccharide) of Bordetella pertussis, the agent of whooping cough, consists of a lipid A linked to a highly branched dodecasaccharide containing several acid and amino sugars. The elucidation of the polysaccharide structure was accomplished by first analyzing the structures of fragments obtained by hydrolysis and nitrous deamination and then piecing the fragments together. The fine structure of the antigenic distal pentasaccharide, presented here, was determined by chemical analyses as well as by high-resolution nuclear magnetic resonance and mass spectrometry. The complete structure was reconstituted and confirmed by matrix-assisted laser desorption/ionization mass spectrometry. The following structure was derived from the combined experimental data:The detailed structure combined with previously reported serological data now allows the synthesis of its epitopes for potential vaccines. (+info)Electrospray mass spectrometry and fragmentation of N-linked carbohydrates derivatized at the reducing terminus. (6/218)
Derivatives were prepared from N-linked glycans by reductive amination from 2-aminobenzamide, 2-aminopyridine, 3-aminoquinoline, 2-aminoacridone, 4-amino-N-(2-diethylaminoethyl)benzamide, and the methyl, ethyl, and butyl esters of 4-aminobenzoic acid. Their electrospray and collision-induced dissociation (CID) fragmentation spectra were examined with a Q-TOF mass spectrometer. The strongest signals were obtained from the [M + Na]+ ions for all derivatives except sugars derivatized with 4-amino-N-(2-diethylaminoethyl)benzamide which gave very strong doubly charged [M + H + Na]2+ ions. The strongest [M + Na]+ ion signals were obtained from the butyl ester of 4-aminobenzoic acid and the weakest from 2-aminopyridine. The most informative spectra were recorded from the [M + Li]+ or [M + Na]+ ions. These spectra were dominated by ions produced by sequence-revealing glycosidic cleavages and "internal" fragments. Linkage-revealing cross-ring cleavage ions were reasonably abundant, particularly from high-mannose glycans. Although the nature of the derivative was found to have little effect upon the fragmentation pattern, 3-aminoquinoline derivatives gave marginally more abundant cross-ring fragments than the other derivatives. [M + H]+ ions formed only glycosidic fragments with few, if any, cross-ring cleavage ions. Doubly charged molecular ions gave less informative spectra; singly charged fragments were weak, and molecular ions containing hydrogen ([M + 2H]2+ and [M + H + Na]2+) fragmented as the [M + H]+ singly charged ions with no significant cross-ring cleavages. (+info)Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. (7/218)
Bisulfite genomic sequencing is the method of choice for the generation of methylation maps with single-base resolution. The method is based on the selective deamination of cytosine to uracil by treatment with bisulfite and the sequencing of subsequently generated PCR products. In contrast to cytosine, 5-methylcytosine does not react with bisulfite and can therefore be distinguished. In order to investigate the potential for optimization of the method and to determine the critical experimental parameters, we determined the influence of incubation time and incubation temperature on the deamination efficiency and measured the degree of DNA degradation during the bisulfite treatment. We found that maximum conversion rates of cytosine occurred at 55 degrees C (4-18 h) and 95 degrees C (1 h). Under these conditions at least 84-96% of the DNA is degraded. To study the impact of primer selection, homologous DNA templates were constructed possessing cytosine-containing and cytosine-free primer binding sites, respectively. The recognition rates for cytosine (>/=97%) and 5-methylcytosine (>/=94%) were found to be identical for both templates. (+info)1-Oxo-2-hydroxy-1,2-dihydroacronycine: a useful synthon in the acronycine series for the introduction of amino substituents at 6-position and for the conversion into isopropylfuroacridones. (8/218)
Thermic aromatic nucleophilic displacement of the methoxy group at C-6 of (+/-)-1-oxo-2-hydroxy-1,2-dihydroacronycine (2) by an amine is a reaction that gives a facile entry to acronycine derivatives bearing an amino substituent at this position. The introduction of the amino substituents was confirmed with a long-range 1H-15N correlation NMR spectrum at natural abundance. Under basic conditions, compound 2 can also be rearranged to the corresponding isopropylfuroacridone 12, in 80% yield. (+info)Acid-base blend membranes based on Nafion®/aminated SPEEK for reducing methanol permeability<...
Iron-Catalyzed C-H Amination « Berkeley Center for Green Chemistry
Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes
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P(i-BuNCH2CH2)3N: An Effective Ligand in the Palladium-Catalyzed Amination of Aryl Bromides and Iodides
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Palladium-Catalyzed Allylic Amination Using Aqueous Ammonia for the Synthesis of Primary Amines
Ir(I)-catalyzed intermolecular regio- and enantioselective hydroamination of alkenes with heteroaromatic amines<...
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Rhodium-catalyzed intermolecular C-H amination of simple hydrocarbons using the shelf-stable nonafluorobutanesulfonyl azide -...
Entwicklung katalytischer Kreuzkupplungs- und Hydroaminierungsreaktionen
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PROCESS FOR HOMOGENEOUSLY CATALYZED, HIGHLY SELECTIVE DIRECT AMINATION OF PRIMARY ALCOHOLS WITH AMMONIA TO PRIMARY AMINES...
Flow Synthesis of Secondary Amines over M/Al2O3 Catalysts (M = Cu, Ag) by One-Pot Reductive Amination of Aldehydes with...
Valorization of biomass derived terpene compounds by catalytic amination<...
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New single-atom catalysis boots reductive amination reaction
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Biotage - A Seminal Supported Resin for Reductive Amination
Asymmetric Catalysis of Planar-Chiral Cyclopentadienylruthenium Complexes in Allylic Amination and Alkylation
A short and flexible route to aza-beta-(1 -| 6)-C-disaccharides: Selective alpha-glycosidase inhibitors
A minireview of hydroamination catalysis: alkene and alkyne substrate selective, metal complex design | BMC Chemistry | Full...
Amidate complexes of titanium and zirconium: a new class of tunable precatalysts for the hydroamination of alkynes | UBC...
In vivo plug-and-play: a modular multi-enzyme single-cell catalyst for the asymmetric amination of ketoacids and ketones |...
Hydroamination via organocatalysis « Naturalproductmans Blog
Publications - Professor Chris Braddock
بهبود عملکرد بیولوژیکی فینگولیمود بارگزاری شده در نانوپارتیکلهای پلی هیدروکسی بوتیرات والرات با استفاده از مشتقات لیوفیل...
TKS Publisher | Digging into the mechanism of oxidative Pd(II)-catalyzed aminations
Chichibabin reaction - Wikipedia
Alfa Aesar™ Di-tert-butyl azodicarboxylate, 98%
| Fisher Scientific
Scientists have found a way to create drug molecules from carbon monoxide | EurekAlert! Science News
One-Pot, Two-Step Reductive Amination of Boronate Ester Containing Aromatic Amines and Aldehydes Using B<sub>2</sub>pin<sub>2...
Domino Hydrogenation−Reductive Amination of Phenols, a Simple Process To Access Substituted Cyclohexylamines | ORGANIC...
Manipulating selectivity of covalently-bonded hyperbranched anion exchangers toward organic acids. Part I: Influence of primary...
E-mail a Wiley Online Library Link
Institut Parisien de Chimie Moléculaire
- 2012
Making Analogues of Trögers Base - Fused oligomers, endo/exo isomers and twisted amides
Process chemistry - Wikipedia
amination of benzene
OpenSCADA: ACS of Phosphating, Amination and Hydrazine of boiler BKZ 160-100 PT
A novel synthesis of tert-leucine via a Leuckart type reaction -ORCA
Synthesis and Biological Evaluation of Radio and Dye Labeled Amino Functionalized Dendritic Polyglycerol Sulfates as...
WoRMS - World Register of Marine Species - Fungia dentigera Leuckart, 1841
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2013-2010 - 叶德举课题组
Mechanistic Model for Enantioselective Intramolecular Alkene Cyanoamidation via Palladium-Catalyzed C-CN Bond Activation<...
The synthesis of biodiesel catalyzed by Mucor miehei lipase immobilized onto aminated polyethersulfone membranes | Bioresources...
Concerning the mechanism of the FeCl<sub>3</sub>-catalyzed α-oxyamination of aldehydes: Evidence for a non-SOMO activation...
US Patent Application for Supported Catalyst Used For Synthesizing Polyether Amine, And Manufacturing Method Patent Application...
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Combining the advantages of homogeneous and heterogeneous catalysis: Rhodium complex on functionalized MCM-41 for the...
Electrophilic Amination of 4-Fluorophenol with Diazenes: A Complete Removal of the Fluorine Atom
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Ross A. Widenhoefer | Duke Chemistry
Ross A. Widenhoefer | Duke Chemistry
Identification of specific markers for amphetamine synthesised from the pre‐precursor APAAN following the Leuckart route and...
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Open Flask: January 2016
Open Flask: January 2016
Application of the Catalyst Wet Pretreatment Method (CWPM) for catalytic direct synthesis of H2O2
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Patent search - Patent Attorneys - Patent Applications - Patent Sale
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KEGG PATHWAY: 2-Oxocarboxylic acid metabolism - Escherichia coli O157:H7 EDL933 (EHEC)
Amination
... is the process by which an amine group is introduced into an organic molecule. This type of reaction is important ... Amination can occur in a number of ways including reaction with ammonia or another amine such as an alkylation, reductive ... In electrophilic amination, the amine as the nucleophile react with another organic compound as the electrophile. This sense of ... Acid-catatlyzed hydroamination Many alkyl amines are produced industrially by the amination of alcohols using ammonia in the ...
Reductive amination
... (also known as reductive alkylation) is a form of amination that involves the conversion of a carbonyl ... ISBN 1-57259-153-6. Current methods for reductive amination Industrial reductive amination at BASF (CS1 French-language sources ... A step in the biosynthesis of many α-amino acids is the reductive amination of an α-ketoacid, usually by a transaminase enzyme ... This approach, known as direct reductive amination (Borch reaction), employs reducing agents that only react slowly (or not at ...
Electrophilic amination
Other electron-deficient, sp3 amination reagents react by similar mechanisms to give substitution products. In aminations ... Electrophilic amination is a chemical process involving the formation of a carbon-nitrogen bond through the reaction of a ... Intramolecular amination is possible, and has been used to prepare small and medium rings. In the example below, deprotonation ... The electrophilic amination of enolates yields α-amino carbonyl compounds. When chiral oxazolidinones are used in conjunction ...
Buchwald-Hartwig amination
Although the scope of the Buchwald-Hartwig amination has been expanded to include a wide variety of aryl and amine coupling ... A Case Study on the Origins of Competing Reduction in the Palladium-Catalyzed Amination of Aryl Halides", J. Am. Chem. Soc., ... In organic chemistry, the Buchwald-Hartwig amination is a chemical reaction for the synthesis of carbon-nitrogen bonds via the ... 3.0.co;2-l Hartwig, J.F. (2008), "Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl ...
Umpolung
doi:10.1016/S0040-4039(00)83958-1. Erdik, E.; Ay, M. (1989). "Electrophilic amination of carbanions". Chemical Reviews. 89 (8 ... can behave as an electrophile at the nitrogen atom and react with a nucleophile as for example in the electrophilic amination ...
Chichibabin reaction
The rate of amination for three azoles proceeds quickest to slowest as follows: 1-methylbenzimidazole > 1-methylnaphth-[2,3-d] ... Amination Chichibabin, A. E.; Zeide, O. A. (1914). "New Reaction for Compounds Containing the Pyridine Nucleus". Zhur. Russ. ... The following is the overall form of the general reaction: The direct amination of pyridine with sodium amide takes place in ... For thermodynamically controlled additions, the rate of amination is related to the stability of the σ-adduct. Ease of hydride ...
Iron-sulfur world hypothesis
Huber, Claudia; Günter Wächtershäuser (February 2003). "Primordial reductive amination revisited". Tetrahedron Letters. 44 (8 ...
Metal-catalysed hydroboration
Fernandez, E.; Maeda, K.; Hooper, M.W.; Brown, J.M. (2000). "Catalytic Asymmetric Hydroboration/Amination and Alkylamination ... "Catalytic asymmetric hydroboration-amination". Chemical Communications (2): 173. doi:10.1039/A606827H. ...
Lithium
Amination of poly(styryl)lithium". Macromolecules. 19 (5): 1291-1294. Bibcode:1986MaMol..19.1291Q. doi:10.1021/ma00159a001. ...
Richmond Sarpong
Jeffrey, Jenna L.; Sarpong, Richmond (2013). "Intramolecular C(sp3)-H amination". Chemical Science. 4 (11): 4092. doi:10.1039/ ...
Hydrogen auto-transfer
Alcohol aminations are among the most commonly utilized borrowing hydrogen processes. In reactions of this type, alcohol ... Homogenous catalysts for alcohol amination based on rhodium and ruthenium were developed by Grigg and Watanabe in 1981. The ... Nitroaromatics can also participate as amine precursors in borrowing hydrogen-type alcohol aminations. The formation of carbon- ... Hamid MH, Slatford PA, Williams JM (2011). "The Catalytic Amination of Alcohols". ChemCatChem. 3 (12): 1853-1864. doi:10.1002/ ...
Aniline
"Aniline synthesis by amination (Arylation)". McMurry, John E. (1992), Organic Chemistry (3rd ed.), Belmont: Wadsworth, ISBN 0- ...
Xile Hu
"Photoelectrocatalytic arene C-H amination". Nature Catalysis. 2 (4): 366-373. doi:10.1038/s41929-019-0231-9. PMC 6459354. PMID ...
Forster-Decker method
Reductive amination Forster, Martin Onslow (1899). "XCI.-Influence of substitution on specific rotation in the bornylamine ...
RNA world
Kumar A, Sharma S, Maurya RA (2010). "Single Nucleotide-Catalyzed Biomimetic Reductive Amination". Advanced Synthesis and ...
Hegedus indole synthesis
Hegedus, Louis S.; Allen, Gary F.; Waterman, Edward L. (1976-04-01). "Palladium assisted intramolecular amination of olefins. A ... "Palladium-assisted intramolecular amination of olefins. Synthesis of nitrogen heterocycles". Journal of the American Chemical ...
Jennifer Schomaker
... chemoselective amination via silver catalysis". Journal of the American Chemical Society. 135 (46): 17238-17241. doi:10.1021/ ... tunable silver-catalyzed C-H amination". Journal of the American Chemical Society. 136 (48): 16720-16723. doi:10.1021/JA5094309 ... and enantioselective C-H amination reactions. 2013 Sloan Research Fellow 2013 National Science Foundation CAREER Award 2013 ...
List of examples of lengths
DNA From The Beginning, section 6: Genes are real things., "Amination" section, final slide Ramel, Gordon. "Spider Silk". ...
Chao-Jun Li
"Palladium-catalyzed Deoxygenative Amination Of Phenols". Science Trends. 2017-12-04. Retrieved 2020-04-17. Xia, Wen-Sheng; ... the direct amination of phenol derivatives. and the fluorescence enhancement due to self-assembling in solution. Reactions in ...
Quicksilver (Marvel Comics)
X-Factor #87: "The X-Amination". Marvel Comics. Son of M #2. Marvel Comics. Son of M #6. Marvel Comics. X-Factor Vol 3 #7. ...
Isatin
Ji, S.J. (2014). "I2/TBHP-Catalyzed Chemoselective Amination of Indoles". Org. Lett. 16: 3094-3097. Kirsch, S.F. (2015). " ... "Copper-Catalyzed Radical Methylation/C-H Amination/Oxidation Cascade for the Synthesis of Quinazolinones". The Journal of ...
Dialkylbiaryl phosphine ligands
This ligand has been utilized in multiple reactions including the amination of a range of aryl halides and triflates as well as ... XPhos supports Pd-based catalysts for amination and amidation of arylsulfonates and aryl halides. XPhos has also been used in ... BrettPhos has been evaluated for the Pd-catalyzed amination of aryl mesylates and aryl halides. Pd-BrettPhos complexes catalyze ... They have proved useful in Buchwald-Hartwig amination and etherification reactions as well as Negishi cross-coupling, Suzuki- ...
Mescaline
Ozonolysis of elemicin followed by reductive amination. Ester reduction of Eudesmic acid's methyl ester followed by ...
Zoltan Hajos
... and α-amination… [reactions] of carbonyl compounds. In the literature, this reaction has been referred to by different names: [ ...
Microplasma
Klages, Claus-Peter; Alena Hinze; Peter Willich; Michael Thomas (2010). "Atmospheric-Pressure Plasma Amination of Polymer ...
Dichlorobis(triphenylphosphine)nickel(II)
Johnson, Jeffrey S.; Berman, Ashley M. (2005-07-01). "Nickel-Catalyzed Electrophilic Amination of Organozinc Halides". Synlett ...
Benjamin List
Subsequently, he developed the first proline-catalyzed Mannich, Michael, and α-amination reactions. He found asymmetric ... List, Benjamin (30 April 2002). "Direct Catalytic Asymmetric α-Amination of Aldehydes". Journal of the American Chemical ...
Hydroamination
doi:10.1016/s0957-4166(03)00429-4. Müller, Thomas E.; Beller, Matthias (1998). "Metal-Initiated Amination of Alkenes and ... Koller, J.; Bergman, R.G. (2010). "Highly Efficient Aluminum-Catalyzed Hydro-amination/-hydrazination of Carbodiimides". ... catalytic amination of monoolefins". J. Mol. Catal. 49: 235-259. doi:10.1016/0304-5102(89)85015-1. Johns, A.M.; Sakai, N.; ...
M. Christina White
Paradine, SM & White, MC (2012). "Iron-Catalyzed Intramolecular Allylic C-H Amination". Journal of the American Chemical ... most recent being the White catalyst's dehydrogenative Diels-Alder reaction and the iron-mediated intramolecular C-H amination ...
Phenylpyruvic acid
Reductive amination of phenylpyruvic acid gives phenylalanine. Phenylpyruvate decarboxylase Phenylpyruvate tautomerase ...
Diastereoconvergent synthesis of anti-1,2-amino alcohols with N-containing quaternary stereocenters via selenium-catalyzed...
2-amino alcohols bearing N-containing quaternary stereocenters using an intermolecular direct C-H amination of homoallylic ... 2-amino alcohols with N-containing quaternary stereocenters via selenium-catalyzed intermolecular C-H amination† ... 2-amino alcohols with N-containing quaternary stereocenters via selenium-catalyzed intermolecular C-H amination T. Zheng, J. L ... 2-amino alcohols bearing N-containing quaternary stereocenters using an intermolecular direct C-H amination of homoallylic ...
Arylamine synthesis by amination (arylation)
A Cu-catalyzed amination of Grignard reagents using cocatalysis by ZnCl2 is described.. A. M. Berman, J. S. Johnson, J. Org. ... A rhodium-catalyzed amination reaction of aryl halides with amines takes place in the presence of a N-heterocyclic carbene ... Amides are excellent N-sources in the NHC-Pd(II)-Im complex catalyzed amination of aryl chlorides. In the presence of KOtBu, ... A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage provides a broad range of aromatic ...
Palladium/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination - Chemical Communications ...
The Pd/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination with a wide range of O- and N ... Palladium/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination† Bin Feng,‡ab Hong-Gang ... The Pd/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination with a wide range of O- and N ... Palladium/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination B. Feng, H. Cheng, J. Chen ...
Convenient C–H amination in complex molecules | Hot Topics | Nature Portfolio
Erowid.org: Erowid Reference 1017 : Clandestine manufacture of 3,4-methylenedioxymethylamphetamine (MDMA) by low pressure...
... by low pressure reductive amination. A mass spectrometric study of some reaction mixtures Forensic Sci Int 1990 45:91-96 ... Attention is paid here to a synthesis of MDMA consisting of a low pressure reductive amination of 3,4-(methylenedioxy) ... "Clandestine manufacture of 3,4-methylenedioxymethylamphetamine (MDMA) by low pressure reductive amination. A mass spectrometric ... "Clandestine manufacture of 3,4-methylenedioxymethylamphetamine (MDMA) by low pressure reductive amination. A mass ...
A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines - Enamine
Case Study - A Pfizer Case Study: Palladium Removal Using SiliaMetS Thiol After a Buchwald-Hartwig Amination
The product from the Buchwald-Hartwig amination of naphthyl bromide with Boc-piperazine was telescoped as a toluene solution ... A Pfizer Case Study: Palladium Removal Using SiliaMetS Thiol After a Buchwald-Hartwig Amination. , back to SiliaMetS Case ... The product from the Buchwald-Hartwig amination of naphthyl bromide with Boc-piperazine was telescoped as a toluene solution ... A Pfizer Case Study: Palladium Removal Using SiliaMetS Thiol After a Buchwald-Hartwig Amination ...
2-Phospinoimidazole-derived Pd(I) and Pd(II) dimer catalysts for Buchwald-Hartwig amination and aminocarbonylation reactions
Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones
... Scheller PN, Lenz M, Hammer S, Hauer B, ... Scheller, P.N., Lenz, M., Hammer, S., Hauer, B., Nestl, B.M.: Imine Reductase-Catalyzed Intermolecular Reductive Amination of ... P.N. Scheller, et al., "Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones", ChemCatChem, ... Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones. ChemCatChem, 7(20), p 3239-3242. ...
Microwave-Assisted Amination of Aryltrifluoroborates
| Bentham Science
A microwave-assisted amination reaction involving aryltrifluoroborates has been developed. This solvent-free coupling reaction ... Microwave-Assisted Amination of Aryltrifluoroborates. Author(s): George W. Kabalka and Li-Li Zhou Volume 3, Issue 4, 2006 ... A microwave-assisted amination reaction involving aryltrifluoroborates has been developed. This solvent-free coupling reaction ... Kabalka W. George and Zhou Li-Li, Microwave-Assisted Amination of Aryltrifluoroborates, Letters in Organic Chemistry 2006; 3(4 ...
Enantioselective aziridination and amination using p-toluenesulfonyl azide in the presence of Ru(salen)(CO) complex<...
Enantioselective aziridination and amination using p-toluenesulfonyl azide in the presence of Ru(salen)(CO) complex. In: ... Enantioselective aziridination and amination using p-toluenesulfonyl azide in the presence of Ru(salen)(CO) complex. / Omura, ... Omura K, Murakami M, Uchida T, Irie R, Katsuki T. Enantioselective aziridination and amination using p-toluenesulfonyl azide in ... Enantioselective aziridination and amination using p-toluenesulfonyl azide in the presence of Ru(salen)(CO) complex. ...
Buchwald-Hartwig Amination
... The inclusion of an article in this document does not give any indication of safety or operability. ... Typically the B-H amination is employed when the desired carbon-nitrogen bond cannot be formed by a classical SNAr reaction due ... The Buchwald-Hartwig (B-H) amination or coupling reaction is a catalytic reaction widely used for the construction of sp2-N ... en.wikipedia.org/wiki/Buchwald%E2%80%93Hartwig_amination. Chem. Soc. Rev., 2008, 37, 639-647 Palladium and copper-catalysed ...
Palladium Catalyzed Amination Kits - HepatoChem
Chichibabin amination: Easy mechanism - Chemistry Notes
Chichibabin amination reaction was first of all reported by Chichibabin in 1914. This reaction involves the formation of the ... Chichibabin amination reaction. Pyridine forms 2-aminopyridine when it reacts with sodium amide in boiling inert solvents like ... Chichibabin amination reaction was first of all reported by Chichibabin in 1914. This reaction involves the formation of the ... Chichibabin amination reaction, chichibabin reaction, chichibabin reaction of pyridine, mechanism of chichibabin reaction ...
DSpace at KOASAS: C2-Selective, Functional-Group-Divergent Amination of Pyrimidines by Enthalpy-Controlled Nucleophilic...
IMSEAR at SEARO: Biotin metabolism in micro-organisms. III. Aspartic-acid oxidation and de-amination.
One-pot monoterpene alcohol amination over Au/ZrO2 catalyst: Effect of the substrate structure<...
N2 - One-pot amination of natural monoterpene alcohols was studied over Au/ZrO2 catalyst, focusing on the structure effect of ... AB - One-pot amination of natural monoterpene alcohols was studied over Au/ZrO2 catalyst, focusing on the structure effect of ... One-pot amination of natural monoterpene alcohols was studied over Au/ZrO2 catalyst, focusing on the structure effect of ... Myrtenol amination was explored with a range of aliphatic and aromatic amines, showing that the primary amine structure ...
Application of a Diphosphinidenecyclobutene Ligand in the Solvent Free Copper-catalysed Amination Reactions of Aryl Halides |...
Gentlemen of Leisure: X-aminations in April 2015
Novel examples of simultaneous reductive azo cleavage and oxidative aromatic ring amination in rhodium complexes of 2-(Arylazo...
Experimental Methodology of C-amination at the C-4 position of Triacetic Acid Lactone
Home - Prof Klaus Hellgardt
Rh-Catalyzed Reductive Amination of Undecanal in an Aqueous Microemulsion System Using a Non-Ionic Surfactant
... the most important parameters for the reaction performance of the reductive amination are the concentrations of reactants. ... The homogeneously catalyzed reductive amination of the long-chain aldehyde undecanal with diethylamine was performed in an ... Rh-Catalyzed Reductive Amination of Undecanal in an Aqueous Microemulsion System Using a Non-Ionic Surfactant. ... The homogeneously catalyzed reductive amination of the long-chain aldehyde undecanal with diethylamine was performed in an ...
Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides | The Hartwig Group
by two times reductive amination of L-configuration were excellent in every - Outlook on PI3K/AKT/mTOR inhibition
Otitis Media Treatment & Management: Medical Care, Surgical Care, Prevention
Data Sheet 1 Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of...
Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase ... Data_Sheet_1_Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of ... Data_Sheet_1_Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of ... Coupling and Regulation of Porous Carriers Using Plasma and Amination to Improve the Catalytic Performance of Glucose Oxidase ...
Intermolecular C-H aminationAryl halidesBuchwald-Hartwig AReactionAminesOxidationAromaticSynthesisAllylicAnnulationKetonesAmmoniaAqueousReagentMechanismGroupCombinationNaturalPositionPublicationsTimeWaterPalladium-catalyzedAldehydes and ketonesAlcoholsAllylic aminationIntroduced via reductive aminationHydrogenationIntramolecularAromatic AminationAlkylationCatalystsAnilineReactionsEnantioselectiveElectrophilicSolvent-freeReductionBenzylicAminoFluorescenceDirectGlycolMetathesisCellularFindings
Intermolecular C-H amination1
- A mild Fe-mediated intermolecular C-H amination of arenes with a highly electrophilic aminating reagent provides unprotected N -methylanilines. (organic-chemistry.org)
Aryl halides1
- A facile and practical copper powder-catalyzed Ullmann amination of aryl halides with aqueous methylamine and other aliphatic primary amines under organic solvent- and ligand-free condition at 100 C and in air gave N -arylamines as sole products in very good yields. (organic-chemistry.org)
Buchwald-Hartwig A2
- The product from the Buchwald-Hartwig amination of naphthyl bromide with Boc-piperazine was telescoped as a toluene solution and the Boc protecting group was subsequently cleaved with HCl gas to afford the HCl salt containing over 1,300 ppm Pd. (silicycle.com)
- Palladium catalyzed amination (Buchwald-Hartwig amination) can be performed using a wide variety of palladium sources, ligands, bases and solvents. (hepatochem.com)
Reaction11
- Natural enzymes are not available for this amination reaction and most currently used chemical catalysts are ill-suited for the functionalization of complex molecules. (natureasia.com)
- A microwave-assisted amination reaction involving aryltrifluoroborates has been developed. (eurekaselect.com)
- The Buchwald-Hartwig (B-H) amination or coupling reaction is a catalytic reaction widely used for the construction of sp 2 -N carbon-nitrogen bonds from amines and aryl/heteroaryl halides or sulfonates. (acsgcipr.org)
- Typically the B-H amination is employed when the desired carbon-nitrogen bond cannot be formed by a classical S N Ar reaction due to low reactivity of the aryl/heteroaryl coupling partner. (acsgcipr.org)
- From an environmental perspective, the B-H amination reaction has a number of challenges. (acsgcipr.org)
- The Pd Catalyzed Amination Kits are ideal tools for the investigation of cross-coupling reaction conditions. (hepatochem.com)
- Chichibabin amination reaction was first of all reported by Chichibabin in 1914. (chemistnotes.com)
- This reaction is known as chichibabin amination or chichibabin reaction. (chemistnotes.com)
- In addition to pressure and temperature, the most important parameters for the reaction performance of the reductive amination are the concentrations of reactants. (tu-berlin.de)
- In this paper, we report the efficient and regioselective synthesis of 2-aminopyrrole-4-carboxylates as derivatives of conformationally restricted analogues of gamma-amino butyrates (GABA) via a zinc perchlorate catalyzed amination-annulation of alpha-cyanomethyl-beta-ketoesters under mild reaction conditions in water. (metu.edu.tr)
- By implementing the gas permeable Teflon AF-2400 tube-in-tube system, diffusion of NH3 from aqueous ammonia to reaction mixture for amination can be achieved in a continuous flow fashion. (novartis.com)
Amines8
- Bis( N -aryl) substituted oxalamides are effective ligands for promoting CuI-catalyzed aryl amination with less reactive (hetero)aryl chlorides at 120 C with K 3 PO 4 as the base in DMSO to afford a wide range of (hetero)aryl amines in good to excellent yields. (organic-chemistry.org)
- 2-aminopyridine 1-oxides are effective ligands for Cu-catalyzed amination of less reactive (hetero)aryl chlorides with aliphatic amines. (organic-chemistry.org)
- A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage provides a broad range of aromatic amines under mild conditions with excellent functional group tolerance at a low catalyst loading. (organic-chemistry.org)
- A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl 2 -TMSOAc (activating agents) and NaBH(OAc) 3 (reducing agent). (enamine.net)
- Myrtenol amination was explored with a range of aliphatic and aromatic amines, showing that the primary amine structure affected both the initial dehydrogenation rate and the selectivity to the desired amine. (abo.fi)
- In this communication, we herein report the use of aqueous ammonia as NH3 source in amination of hetereoaryl chorides to generate primary heteroaryl amines, providing a protocol that is green, economical and safe. (novartis.com)
- The amines were obtained from galactopyranosides through 2,3-anhydrogulosides that were opened to idosides followed by an oxidation/reductive amination sequence. (lu.se)
- Reductive amination is one of the most important methods for the synthesis of chiral amines. (araid.es)
Oxidation2
- Aspartic-acid oxidation and de-amination. (who.int)
- Recent our contribution for the development of chemoselective catalysis, such as conjugate addition, amination/oxidation and oxidative cross coupling, will be presented. (ntu.edu.sg)
Aromatic1
- Goswami, Sreebrata (1999) Novel examples of simultaneous reductive azo cleavage and oxidative aromatic ring amination in rhodium complexes of 2-(Arylazo)pyridine Organometallics, 18 (24). (ias.ac.in)
Synthesis2
- We report a diastereoconvergent synthesis of anti -1,2-amino alcohols bearing N-containing quaternary stereocenters using an intermolecular direct C-H amination of homoallylic alcohol derivatives catalyzed by a phosphine selenide. (rsc.org)
- Attention is paid here to a synthesis of MDMA consisting of a low pressure reductive amination of 3,4-(methylenedioxy)phenylpropanone with methylamine. (erowid.org)
Allylic2
- The Pd/sulfoxide-phosphine-catalyzed highly enantioselective allylic etherification and amination with a wide range of O- and N-nucleophiles have been developed (up to 97% yield, 98.5% ee). (rsc.org)
- R,R)-Ru(salen)(CO) complex (1) was found to catalyze enantioselective aziridination of conjugated terminal olefins and allylic C-H amination of conjugated olefins bearing geminal- and/or trans-substituent(s) in the presence of p-toluenesulfonyl azide. (elsevier.com)
Annulation1
- Zinc perchlorate catalyzed one-pot amination-annulation of alpha-cyanomethyl-beta-ketoesters in water. (metu.edu.tr)
Ketones1
- An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO₃H)₃/SiO₂(SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. (ias.ac.in)
Ammonia3
- Catalyst-free and protecting group free nucleophilic amination using ammonia represents a green and atom-economical method. (novartis.com)
- Industrially, aspartate is produced by amination of fumarate catalyzed by L- aspartate ammonia-lyase . (wikipedia.org)
- reductive amination of α-keto acids with ammonia catalyzed by acid-stable iridium hydride complexes in water[J]. Journal of the American Chemical Society, 2004, 126(10):3 020-3 021. (cnif.cn)
Aqueous1
- The homogeneously catalyzed reductive amination of the long-chain aldehyde undecanal with diethylamine was performed in an aqueous microemulsion system using the non-ionic surfactant Marlophen NP8. (tu-berlin.de)
Reagent1
- Mechanism-based reagent design allowed for the C2-selective amination of pyrimidines, opening the new scope of site-selective heteroaryl C-H functionalization. (kaist.ac.kr)
Mechanism1
- Now, a biocatalytic amination strategy using a new-to-nature mechanism involving nitrogen-centred radicals has been developed. (nature.com)
Group1
- Bicyclic (myrtenol and nopol, bearing an unconjugated -OH group) and monocyclic (perillyl) alcohols were chosen for aniline amination under comparable conditions. (abo.fi)
Combination2
- Surface modification was carried out via a combination of plasma and amination to promote the properties of the catalyzer. (figshare.com)
- Finally, the obtained crude ortho -ethoxyvinyl benzylamines are cyclized via an intramolecular reductive amination using the combination of triethylsilane/TFA to give the desired N -aryl-1,2,3,4-tetrahydroisoquinolines. (sfb1309.de)
Natural1
- One-pot amination of natural monoterpene alcohols was studied over Au/ZrO2 catalyst, focusing on the structure effect of substrates selected based on their pharmaceutical relevance. (abo.fi)
Position1
- This project focuses on C-amination at the C-4 position. (emerging-researchers.org)
Publications1
- Original publications on B-H amination used aminostannanes as coupling partners-it was later demonstrated that the use of organotin derivatives is not required. (acsgcipr.org)
Time2
- We have demonstrated, for the first time, that nitrogen radical undergo strain-release amination with [1.1.1]propellane and that this reactivity can be used for the divergent and single-step assembly of these molecules. (europa.eu)
- We also demonstrate preparative scale reductive aminations with wild-type and Q240A variant biocatalysts displaying total turnover numbers of up to 32,000 and space-time yields up to 3.73 g l−1 d−1. (araid.es)
Water1
- A rhodium-catalyzed amination of phenols provides diverse anilines, with water as the sole byproduct. (organic-chemistry.org)
Palladium-catalyzed4
- New Ligands for a General Palladium-Catalyzed Amination of Aryl and Heteroaryl Chlorides. (sigmaaldrich.com)
- that azetidines such as 33 can be prepared via palladium-catalyzed C-H amination of 32 . (organic-chemistry.org)
- The basic principles and elementary steps required to understand homogeneous catalysis will be covered using selected examples from a range of important transformation selected from rhodium- and cobalt-catalyzed hydroformylation, rhodium and ruthenium-catalysed hydrogenation, alkene oligomerisation and polymerization, metathesis, isomerization reactions, palladium catalyzed cross couplings and aminations, carbonylation of alkenes, rhodium catalyzed cyclisations and palladium catalyzed oxidation of alkenes. (ncl.ac.uk)
- 2003. Palladium-catalyzed amination of aryl nonaflates. (innspub.net)
Aldehydes and ketones4
- Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. (organic-chemistry.org)
- Trimethyl borate promotes a solvent-free reductive amination of aldehydes and ketones with aliphatic and aromatic amines in very good yields in the presence of ammonia borane as reductant. (organic-chemistry.org)
- Dibutyltin dichloride catalyzes a direct reductive amination of aldehydes and ketones in the presence of phenylsilane as a stoichiometric reductant. (organic-chemistry.org)
- One-pot reductive amination of aldehydes and ketones is an important transformation in organic chemistry, and several common reducing agents are available for the direct conversion of carbonyl products into amines. (sigmaaldrich.com)
Alcohols2
- Heterogeneous catalysts comprising nickel oxide, copper oxide, zirconium oxide and molybdenum oxide for the amination of alcohols by means of ammonia and hydrogen are known from EP 0 696 572 A1. (justia.com)
- Reductive amination , amination of alcohols and aminocarbonylation reactions. (catalysis.de)
Allylic amination1
- Ritter, T. Allylic Amination of Alkenes with Iminothianthrenes to Afford Alkyl Allylamines. (mpg.de)
Introduced via reductive amination1
- These tags are introduced via reductive amination in the presence of an acid catalyst and a reducing agent. (neb.com)
Hydrogenation2
- The straightforward metalation of MOF secondary building units (SBUs) with cobalt and iron salts affords highly active and reusable single-site solid catalysts for a range of organic reactions, including chemoselective borylation, silylation and amination of benzylic C-H bonds, as well as hydrogenation and hydroboration of alkenes and ketones. (nature.com)
- Dicyclohexylamine can be produced from the amination of Cyclohexanone by some hydrogenation conditions. (industryarc.com)
Intramolecular3
- Reductive amination of (protected) 3-Oxopropanenitrile: Will azetidin-2-ol be formed via intramolecular ring closure? (stackexchange.com)
- For product 2, if you go for the intramolecular route then the product of a reductive amination should be azetidine. (stackexchange.com)
- 2) Enantioselective intramolecular benzylic C-H amination of primary aliphatic azides was achieved by using a chiral-at-metal bis(pyridyl-NHC) ruthenium complex in combination with tris(p-fluorophenyl)phosphine (both 1 mol%) to provide a variety of chiral -aryl pyrrolidines with enantioselectivities of up to 99% ee. (uni-marburg.de)
Aromatic Amination2
- 2010). An Aromatic Amination Approach Towards Ancistrocladinium A/B . Synlett , 939-943. (uea.ac.uk)
- Multiple aromatic amination mediated by a diiron complex. (univ-grenoble-alpes.fr)
Alkylation1
- CH-oxidation, CH-amination, CH-(methyl) alkylation and dehydrogenation reactions. (catalysis.de)
Catalysts4
- The [email protected] and [email protected] MOF materials are highly active and reusable single-site solid catalysts for site-selective sp 3 C-H functionalization reactions, such as undirected benzylic C-H borylation, silylation and amination. (nature.com)
- These catalysts were used for liquid-phase amination of toluene to toluidines. (akjournals.com)
- A research team led by Prof. LIU Licheng from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) proposed a two-step amination strategy to regulate the electronic structure of M-N/C catalysts (M=Ni, Fe, Zn) and enhance the intrinsic activity of CO 2 electrocatalytic reduction. (brightsurf.com)
- To this end, over the past decades, researchers have been reported several studies on reductive amination reaction with several different catalysts, which among them, heterogeneous catalysis are prominent than homogenous catalysis owing to separate and recover capabilities. (ukessays.com)
Aniline2
- Facile and clean transformation for synthesizing secondary arylamines through one-pot reductive amination of aniline, using aldehyde catalyzed by the supported nickel and poly(vinyl sulfonic acid) on mesoporous carbon CMK-3 (Ni/PVSA/CMK-3) as a novel acid-metal bi-functional heterogeneous catalyst. (ukessays.com)
- Amination of cyclohexanone, amination of phenol and aniline. (industryarc.com)
Reactions4
- The desired doubly aminated diaminodiethylene glycol is obtained only in extremely low yields, if at all, in the amination reactions of the abovementioned documents. (justia.com)
- In the reaction of polyetherols, undesired secondary reactions to form the dimeric secondary amine or polymeric coupling products are observed to a substantial extent in the above-described processes for heterogeneously catalyzed amination. (justia.com)
- 1 To test the potency of these new ligands, the team of scientists carried out several common cross-coupling reactions: Suzuki, Sonogashira and Buchwald-Hartwig amination ( Figure 1 ). (sigmaaldrich.com)
- The novel dyes were prepared through by halogenation, oxidation, imidation and amination reactions. (emerald.com)
Enantioselective1
- a copper-catalyzed enantioselective amination-Heck-type cascade (e.g. 15 and 16 to 17 ) that is thought to proceed via radical intermediates. (organic-chemistry.org)
Electrophilic1
- The method relies on the electrophilic amination of the corresponding stereochemically pure sulfinates with N -alkylhydroxylamine sulfonic acids (in turn easily prepared from N -alkylhydroxylamine and HSO 3 Cl). (enamine.net)
Solvent-free1
- Furthermore, this reagent is effective at direct reductive aminations in methanol, water, or even solvent-free conditions ( Scheme 1 ). (sigmaaldrich.com)
Reduction2
- It is very useful in reductive amination and in the reduction of imines. (silicycle.com)
- (EN) The present invention is directed to the reduction of an N-imine moiety or a hemiaminal moiety of a morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source. (wipo.int)
Benzylic1
- First, the development of a novel C-H amination strategy using both a Cu(II) Lewis acid and an organic hydrogen atom transfer (HAT) catalyst to activate benzylic C-H bonds adjacent to aromatic azaheterocycles is described. (mit.edu)
Amino1
- The chain modification modules RM002 (including RM032 ) and RM033 , together with a reductive amination step ( RC00006 or RC00036 ), generate basic and branched-chain amino acids, respectively. (genome.jp)
Fluorescence1
- N-glycans can be enzymatically released PNGase F (Glycerol-free), Recombinant after which they can be derivatized by premethylation or fluorescence labeling (via reductive amination). (neb.com)
Direct1
- There are two detached approaches for the reductive amination: the direct approach, which uses the in situ-generated imine, and the indirect approach, which uses the prior isolated imine. (ukessays.com)
Glycol1
- In our pursuit to develop exogenous fluorescent tracers for real-time monitoring of renal function by optical methods, Nalkylated aminopyrazine dyes and their hydrophilic conjugates based on poly (ethylene glycol) (PEG) were synthesized via reductive amination as the key step. (njit.edu)
Metathesis1
- Ring closing metathesis of D-glucose derived diene-substrate containing nitrogen functionality followed by asymmetric dihydroxylation afforded sugar substituted dihydroxylated pyrrolidines 8a-c which on 1,2-acetonide deprotection and reductive amination afforded putative uniflorine A 2a and its analogues 2b-c, respectively. (ias.ac.in)
Cellular1
- On the flexibility of the cellular amination network in E. coli. (mpg.de)
Findings1
- To enable students to present their Master Thesis in the form of a lecture in front of an ex-amination commission, to defend the findings and to answer questions that may arise in the subsequent discussion. (uibk.ac.at)