Amikacin
Kanamycin
Aminoglycosides
Gentamicins
Netilmicin
Tobramycin
Microbial Sensitivity Tests
Ceftazidime
Drug Resistance, Microbial
Sisomicin
Pseudomonas aeruginosa
Dibekacin
Labyrinthine Fluids
Piperacillin
Imipenem
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
Kanamycin Kinase
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Acinetobacter
Carbenicillin
Drug Therapy, Combination
Perilymph
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Aztreonam
Clofazimine
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
Serratia
Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/633)
Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin. (+info)UK-18892, a new aminoglycoside: an in vitro study. (2/633)
UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin against gentamicin-susceptible strains of Pseudomonas aeruginosa. Both amikacin and UK-18892 were equally active against gentamicin-resistant strains of P. aeruginosa. There were no appreciable differences in the activity of UK-18892 and amikacin against Enterobacteriaceae and Staphylococcus aureus. Cross-resistance between these two antimicrobials was also apparent. (+info)Bacteriologic cure of experimental Pseudomonas keratitis. (3/633)
Two long-term therapy trials with high concentrations of antibiotic were carried out to determine the duration of therapy required to achieve bacteriologic cure of experimental Pseudomonas keratitis in guinea pigs. In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml. In an 11-day trial of topical therapy with tobramycin 20 mg/ml, 34 of 36 corneas grew no Pseudomonas after 6 or more days of therapy. The bacteriologic response to therapy in this model occurred in two phases. About 99.9% or more of the organisms in the cornea were killed in the first 24 hr of therapy. The numbers of bacteria remaining in the cornea declined gradually over the next several days until the corneas were sterile. Optimal antibiotic therapy may include two stages: initial intensive therapy with high concentrations of antibiotic applied frequently to achieve a large rapid decrease in numbers of organisms in the cornea, followed by prolonged, less intensive therapy to eradicate organisms and prevent relapse. (+info)Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (4/633)
Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin. (+info)Killing kinetics of intracellular Afipia felis treated with amikacin. (5/633)
Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria. (+info)Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (6/633)
AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin. (+info)Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. (7/633)
Netilmicin (Sch 20569) is a new broad-spectrum semisynthetic aminoglycoside derived from sisomicin. Netilmicin was compared to gentamicin, tobramycin, and amikacin in a variety of in vitro test systems as well as in mouse protection tests. Netilmicin was found to be similar in activity to gentamicin against aminoglycoside-susceptible strains in both in vitro and in vivo tests. Netilmicin was also active against many aminoglycoside-resistant strains of gram-negative bacteria, particularly those known to possess adenylating enzymes (ANT 2') or those with a similar resistance pattern. Netilmicin was found to be markedly less toxic than gentamicin in chronic studies in cats, although gentamicin appeared less toxic in acute toxicity tests in mice. The concentrations of netilmicin and gentamicin in serum were compared in dogs after intramuscular dosing, and the pharmacokinetics including peak concentrations in serum were found to be similar. (+info)Randomized prospective study comparing cost-effectiveness of teicoplanin and vancomycin as second-line empiric therapy for infection in neutropenic patients. (8/633)
BACKGROUND AND OBJECTIVE: The current health-care philosophy dictates that new therapies should always be evaluated for their economic impact. Along with acquisition cost, the cost of delivery, monitoring, adverse effects and treatment failure must also be considered when determining the total cost of therapy. These auxiliary costs can be significant and greatly alter the overall cost of a drug treatment. We conducted a prospective randomized study to evaluate the efficacy, safety and cost of vancomycin and teicoplanin therapy in patients with neutropenia, after the failure of empirical treatment with a combination of piperacillin/tazobactam and amikacin. DESIGN AND METHODS: Seventy-six febrile episodes from 66 patients with hematologic malignancies under treatment, neutropenia (neutrophils <500/mm3) and fever (38 degrees C twice or 38.5 degrees C once) resistant to the combination piperacillin/tazobactam and amikacin were included in the study. RESULTS: Primary success of second-line therapy was obtained in 35 cases (46%) with no significant difference between vancomycin (17/38) and teicoplanin arms (18/38). No difference in renal or hepatic toxicity related to the antibiotic therapy was observed. The average cost per patient according to glycopeptide used was $450+/-180 for the teicoplanin group and $473+/-347 for the vancomycin group. Interestingly, in the teicoplanin arm, drug acquisition accounted for 97% of the total cost, while in the vancomycin arm administration and monitoring play an important role in overall costs. INTERPRETATION AND CONCLUSIONS: In conclusion, our pharmacoeconomic analysis demonstrates that teicoplanin and vancomycin can be administered in neutropenic hematologic patients with similar efficacy and direct costs. (+info)Buy Likacin (Amikacin) Without Prescription
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Abstract: Pharmacokinetics of Intravenous Amikacin in Intermittent Hemodialysis: Treatment of Peritoneal Dialysis Peritonitis...
In vitro potency of amikacin and comparators against E. coli, K. pneumoniae and P. aeruginosa respiratory and blood isolates |...
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US9333214B2 - Method for treating pulmonary disorders with liposomal amikacin formulations - Google Patents
Macular infarction after intravitreal amikacin: mounting evidence against amikacin | British Journal of Ophthalmology
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Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium...
Defining the potency of amikacin against Escherichia coli, Klebsiella | IDR
Amikacin (By injection)
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients...
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Incidence of an aminoglycoside 6′-N-acetyltransferase, ACC (6′)-1b, in amikacin-resistant clinical isolates of gram-negative...
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Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia - Full Text View - ClinicalTrials.gov
Effect of Netilmicin and Amikacin on Urinary Phospholipids Excretion in Humans | Springer for Research & Development
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An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the...
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Phase III study program with Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients...
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Amikacin
Around 16% of amikacin crosses the placenta; while the half-life of amikacin in the mother is 2 hours, it is 3.7 hours in the ... The concentration of amikacin in the renal cortex becomes ten times that of amikacin in the plasma; it then most likely ... Amikacin is derived from kanamycin A: While amikacin is only FDA-approved for use in dogs and for intrauterine infection in ... Amikacin in the eye can be accompanied by cephazolin. Despite its use there amikacin (and all aminoglycosides) are toxic to ...
Mycobacteroides salmoniphilum
M. salmoniphilum is susceptible to amikacin. Whipps CM, Butler WR, Pourahmad F, Watral VG, Kent ML. (2007). "Molecular ...
Ampicillin
"Drug interactions between amikacin and ampicillin". Drugs.com. Archived from the original on 23 February 2018. Retrieved 22 ...
Clostridial necrotizing enteritis
... or amikacin) plus metronidazole •Ampicillin plus gentamicin (or amikacin) plus clindamycin •Ampicillin plus an expanded- ... Centers with significant gentamicin resistance patterns should consider amikacin in place of gentamicin. The use of oral ...
Hospital-acquired pneumonia
cefepime, ceftazidime, imipenem, meropenem or piperacillin-tazobactam; plus ciprofloxacin, levofloxacin, amikacin, gentamicin, ...
Mycobacterium mucogenicum
Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...
Mycobacterium murale
Susceptible to amikacin, azithromycin, ciprofloxacin, clarithromycin and ethambutol. Resistant to isoniazid. Differential ...
Mycolicibacillus parakoreensis
It is susceptible to amikacin, clarithromycin, and rifampin. Kim BJ, Hong SH, Yu HK, Park YG, Jeong J, Lee SH, Kim SR, Kim K, ...
Mycobacteroides saopaulense
M. saopaulense is susceptible to amikacin, kanamycin, and clarithromycin. Nogueira CL, Whipps CM, Matsumoto CK, Chimara E, Droz ...
Mycobacterium bohemicum
Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...
Ototoxic medication
The most frequently used aminoglycosides include gentamicin, amikacin and streptomycin. These antibiotics are usually used in ...
Mycolicibacter engbaekii
It is susceptible to amikacin, clarithromycin, ethambutol, linezolid, and rifabutin. It has also been recovered from African ...
Plazomicin
April 2012). "Comparison of the Next-Generation Aminoglycoside Plazomicin to Gentamicin, Tobramycin and Amikacin". Expert ...
Treatment of infections after exposure to ionizing radiation
c. Third choice: gentamicin or amikacin (both aminoglycosides) +/- amoxicillin or vancomycin (all injectable). Aminoglycosides ... amikacin]) Antibiotics directed against Gram-positive bacteria need to be included in instances and institutions where ...
Pseudomonas
Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy.[citation needed] This ability to ...
Rifampicin
... is antagonistic to the microbiologic effects of the antibiotics gentamicin and amikacin. The activity of rifampicin ...
Nocardiosis
A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ...
Enterobacter
Aminoglycosides such as amikacin have been found to be very effective, as well. Quinolones can be an effective alternative. A ...
Cefbuperazone
"In vivo bacterial regrowth-inhibition effect of cefbuperazone and amikacin in puerperal uterine cavity". Journal of ...
Nocardia
Minocycline is usually substituted when a sulfa cannot be given; high-dose imipenem and amikacin have also been used in severe ...
Continuous fever
... gentamicin and amikacin. Intermittent fever Relapsing fever Undulant fever Remittent fever Neutropenic fever Ogoina D (August ...
Streptomyces somaliensis
"Refractory Craniofacial Actinomycetoma Due to Streptomyces somaliensis That Required Salvage Therapy with Amikacin and Imipenem ...
Pharmacokinetics
"Phase I Pharmacokinetics of Liposomal Amikacin (MiKasome) in Human Subjects: Dose Dependence and Urinary Clearance". Abstr ...
Cefpiramide
Sampi K, Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic ...
Mycobacterium stephanolepidis
... kanamycin and amikacin. Reports from 2009 stated that there was a high mortality rate among the thread-sail filefish, ...
Hypersensitivity
For drug-resistant TB, a combination of antibiotics such as amikacin, kanamycin, or capreomycin should be used. The most common ...
Netilmicin
... and amikacin are the drugs most often used in clinical trials of once-daily dosing regimens. Ugeskrift for Lægerer. ... amikacin), and it is more expensive; thus, its potential value is limited. Drug Intelligence & Clinical Pharmacy: Vol. 17, No. ...
Clofazimine
"Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains Exposed to Amikacin and ... as well as the drugs amikacin and clarithromycin. However, in the United States, clofazimine is considered an orphan drug, is ...
Chromobacterium violaceum
Antibiotics that have been used to successfully treat C. violaceum include pefloxacin, ciprofloxacin, amikacin, and co- ...
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The type strain isolates were susceptible in vitro to ciprofloxacin, amikacin, tobramycin, cefoxitin, clarithromycin, ...
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Amikacin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use amikacin injection until you finish the prescription, even if you feel better. If you stop using amikacin injection too ... Before receiving amikacin injection,. *tell your doctor and pharmacist if you are allergic to amikacin injection; other ... If you become pregnant while using amikacin injection, call your doctor immediately. Amikacin may harm the fetus. ...
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Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate ... Teva is recalling 7 lots of its amikacin sulfate injection 500 mg/2 mL (250 mg/mL) and 1 gram/4 mL (250 mg/mL) vials because of ... Intravenous (IV) amikacin sulfate is an aminoglycoside antibiotic typically used to treat serious infections caused by strains ... Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate ...
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Ketoconazole / Amikacin / Triamcinolone preparation information is provided by Wedgewood Pharmacy. ... Amikacin / Triamcinolone EZ Dose Ear Pack may be prescribed for Dogs and Cats. ... Ketoconazole / Amikacin / Triamcinolone: EZ Dose Ear Pack. Ketoconazole / Amikacin / Triamcinolone may be prescribed for:. * ... 1 strength combination of Ketoconazole / Amikacin / Triamcinolone EZ Dose Ear Pack is available.*Amikacin (as Sulfate) 0.67 % ...
In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for...
Mandal, S., Mandal, M.D. & Pal, N.K. (2009). In vitro activity of gentamicin and amikacin against Salmonella enterica serovar ... In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for ... This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained ... The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 microg/mL and 0.005- ...
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WHO EMRO | In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment...
In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for ... There was an increase in the MIC of amikacin from 0.005 μg/mL (in 1994) to 0.25 μg/mL (in 1997), while the values ranged from ... CFU/mL for amikacin (2 µg/mL), indicating the bactericidal activity of the antibiotics against S. enterica serovar Typhi. At ... However, in our study, the MICs of gentamicin and amikacin were 0.01-4 μg/mL and 0.005-3.5 μg/mL respectively, which is even ...
The Protective Effects of Nigella sativa Oil and Allium sativum Extract on Amikacin-induced Nephrotoxicity
Rats received nephrotoxic dose of amikacin and the amelioration of amikacin-induced nephrotoxicity was assessed through ... This study was designed to check the effect of Nigella sativa oil and Allium sativum extract in ameliorating amikacin-induced ... The Protective Effects of Nigella sativa Oil and Allium sativum Extract on Amikacin-induced Nephrotoxicity. International ... Abstract: Amikacin is a valuable aminoglycoside in serious infections. However, its use is associated with undesirable renal ...
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Systemic delivery of amikacin is a widely adopted treatment modality for severe infections like sepsis. However, the current ... Amikacin has short half-life, which further challenges the delivery of sufficient systemic concentrations when administered by ... The zone of inhibition for Ak-lip and amikacin was found to be 22 mm and 26 mm against Staphylococcus aureus. The minimum ... To solve this issue, novel delivery systems, amikacin liposomes (Ak-lip) were developed and evaluated for its antibacterial ...
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Serum Amikacin Levels And Hearing In Very Low Birth Weight (VLBW) Infants
Mean peak serum amikacin level (μg/mL) was 14.5±3.16 in 7 days amikacin group; and 24.8±3.95 in 14 days amikacin group. All ... Results: Mean trough serum amikacin level (μg/ml) was 6.85±2.49 in 7 days amikacin group; and 15.2±3.41 in 14 days amikacin ... Intervention: Amikacin administration as per their setting of indication. Outcome measures: Serum amikacin levels and hearing ... Participants: 30 VLBW infants who received amikacin for 7 days, 30 VLBW infants who received amikacin for 14 days and 30 VLBW ...
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Mycobacterium Avium Complex (MAC) (Mycobacterium Avium-Intracellulare [MAI]) Medication: Antibiotics
Alternatively, clofazimine, streptomycin, amikacin, or a fluoroquinolone may be used as a substitute for one of the first-line ... Amikacin is used for refractory cases.. Clofazimine should be avoided in patients with disseminated MAC (DMAC) infection ... Amikacin irreversibly binds to the 30S subunit of bacterial ribosomes, blocks the recognition step in protein synthesis, and ... Aerosolized amikacin for treatment of pulmonary Mycobacterium avium infections: an observational case series. BMC Pulm Med. ...
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... amikacin liposome inhalation), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & ... encoded search term (amikacin liposome inhalation (Arikayce)) and amikacin liposome inhalation (Arikayce) What to Read Next on ... Animal reproductive toxicology studies have not been conducted with inhaled amikacin. *SC administration of amikacin to ... Given low systemic exposure to amikacin following administration, clinically relevant accumulation of amikacin is unlikely to ...
Amikacin EP Impurity I - Axios Research
Amikacin EP Impurity E. Synonym. (S)-4-amino-N-(((2R,3S,4S,5R,6R)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino ... Amikacin EP Impurity C. Synonym. (S)-4-amino-N-((2S,3R,4S,5S,6R)-2-(((1S,2R,3R,4S,6R)-4,6-diamino-3-(((2R,3R,4S,5S,6R)-6-( ... Amikacin EP Impurity D. Synonym. (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino ... Amikacin EP Impurity H. Synonym. (S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-( ...
Amikacin Sulfate Injection Topfond Pharmaceutical Co., Ltd.
Amikacin | Medicine | Annotated Medicine and Device Lists
AMIKACIN SULPHATE-30ml
GentamicinLiposome inhalation suspensionInjectionInhalationTobramycinFluoroquinolones500MGMinimum inhibitory concentrationsAntibioticsKanamycinSULPHATELiposomal amikacinInfectionsIntravenouslyVitroSystemicAminoglycoside antibioticStreptomycinMycobacteriaAeruginosaImipenemResistanceAntibacterial activityNephrotoxicityCause serious kidney problemsEfficacyAdverse effectsDoseIsolatesDrugRenalLungPatientsSevereTreatment
Gentamicin5
- This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained from blood of patients clinically suspected of enteric fever who attended the Calcutta School of Tropical Medicine from 1991 to 2003. (who.int)
- The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 microg/mL and 0.005-3.5 microg/mL respectively. (who.int)
- The same principles of drug monitoring for gentamicin apply to amikacin. (medscape.com)
- Amikacin and gentamicin find maximum usage in veterinary medicine. (grandviewresearch.com)
- Amikacin (100%), imipenem (94.7%), ciprofloxacin (68.4%), and gentamicin (63.1%) were the most effective antibiotics against Staph. (qscience.com)
Liposome inhalation suspension1
- When intensification of therapy with amikacin is being considered, or has been implemented in patients, how do you differentiate between and/or decide to initiate therapy with the IV vs. amikacin liposome inhalation suspension formulation? (iqanda-cme.com)
Injection28
- Your doctor may not want you to receive amikacin injection. (medlineplus.gov)
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection. (medlineplus.gov)
- Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (medlineplus.gov)
- Amikacin injection is in a class of medications called aminoglycoside antibiotics. (medlineplus.gov)
- Antibiotics such as amikacin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). (medlineplus.gov)
- You may receive amikacin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
- If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with amikacin injection. (medlineplus.gov)
- Use amikacin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
- If you stop using amikacin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- or any of the ingredients in amikacin injection. (medlineplus.gov)
- Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate matter. (pharmacytimes.com)
- How does Amikacin injection BP work? (salvavidaspharma.com)
- Amikacin 250mg Injection is an injectable antibiotic that stops the growth of bacteria that cause infections in the body. (salvavidaspharma.com)
- What if you forget to take Amikacin injection BP work? (salvavidaspharma.com)
- Call your doctor if you miss a dose of Amikacin injection BP. (salvavidaspharma.com)
- Amikacin 250mg for injection is an antibiotic used to prevent or treat various bacterial infections. (salvavidaspharma.com)
- Amikacin Sulfate Injection_Topfond Pharmaceutical Co., Ltd. (topfond.com)
- Amikacin is an injection antibacterial used to treat serious infections. (insheal.in)
- Mikacin 250 MG Injection (Amikacin Injection) is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci, Enterococci, etc. (genericonlinemeds.com)
- Amikacin Injection is known to cause serious kidney problems and hearing problems, especially in the elderly population. (genericonlinemeds.com)
- Amikacin Sulphate Injection is an antibiotic used to prevent or treat a wide variety of bacterial infections. (rednirusmart.com)
- Amikacin Sulphate Injection works by stopping the growth of bacteria It should not be self-administered and is provided via drip (intravenous infusion) or injection into a vein or muscle under the guidance of a medical practitioner. (rednirusmart.com)
- If you want to manufacture your own Amikacin Sulphate 250 mg Injection brand in third party then find the contact details of the WHO and GMP certified third party manufactures in Teni. (rednirusmart.com)
- How many Amikacin Sulphate Injection Manufacturing Companies associated with Rednirus Mart in Teni? (rednirusmart.com)
- There are approxx 50+ Amikacin Sulphate injection third party pharma manufacturing companies listed on our online b2b pharmaceutical marketplace like Janus Biotech, SNU Biocare, SP Pharmaceutical and many more. (rednirusmart.com)
- This fact sheet is a step-by-step guideline discussing the supplies required, limitations and precautions, pharmacokinetics, proper storage, and accurate placement for injection of Amikacin with picture guides. (cdc.gov)
Inhalation4
- amikacin liposome inhalation increases effects of abobotulinumtoxinA by pharmacodynamic synergism. (medscape.com)
- sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of amikacin liposome inhalation by Other (see comment). (medscape.com)
- Objectives To evaluate the colocalization of an amikacin liposomal inhalation suspension (ALIS) with intracellular Mabs, and then to measure its intracellular anti-Mabs activity. (uvsq.fr)
- Insmed is planning to commence a Phase 2 clinical trial of Arikace (liposomal amikacin for inhalation) in patients with non-tuberculous mycobacteria (NTM) lung disease, and an European registration Phase 3 study in Cystic Fibrosis (CF) patients with Pseudomonas aeruginosa (Pa) lung infections. (clinicaltrialsarena.com)
Tobramycin1
- Consequently, analysis focused on pentamidine, classified by NIOSH as a hazardous drug, and the antibiotics amikacin, colistin, and tobramycin, which currently lack authoritative safe handling guidelines. (cdc.gov)
Fluoroquinolones1
- The Xpert MTB/XDR assay was used as a reflex test to detect resistance to isoniazid , fluoroquinolones , ethionamide , amikacin , kanamycin , and capreomycin in adults with positive results for Mycobacterium tuberculosis complex on Xpert MTB/RIF or Ultra (Cepheid). (bvsalud.org)
500MG1
- Amikacin 500mg Inj. (dawaai.pk)
Minimum inhibitory concentrations1
- The minimum inhibitory concentrations (MIC) of amikacin and Ak-lip against Staphylococcus aureus were found to be 3 µg/mL and 9 µg/mL, and for Pseudomonas aeruginosa were 0.6 µg/mL and 0.9 µg/mL respectively. (simulations-plus.com)
Antibiotics1
- The group of drugs known as aminoglycoside antibiotics includes amikacin. (rednirusmart.com)
Kanamycin3
- Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study. (bvsalud.org)
- Aminoglycosides used in the treatment of MDR-TB include kanamycin capreomycin, and amikacin. (grandviewresearch.com)
- Use of kanamycin in MDR-TB is recommended after failure of capreomycin but before treatment with amikacin However, presence of substitutes such as amikacin is expected to restrain kanamycin demand as amikacin was found to be more effective at critical concentration as compared to capreomycin and kanamycin on testing their efficacies on the wild-type M. tuberculosis. (grandviewresearch.com)
SULPHATE8
- Amikacin Sulphate 500 mg Injections Pharma PCD Franchise Suppliers & M. (rednirusmart.com)
- Get the list for amikacin sulphate 500 mg injections pharma pcd franchise suppliers & manufacturers in India ?Healthkind PCD pharma Supplier & manufacturer are India based India's top leading pcd pharmaceutical franchise company that provides a wide range of pharma franchise products, all products a. (rednirusmart.com)
- Amikacin Sulphate 100 Mg Injectables Pharma Franchise Suppliers & Manu. (rednirusmart.com)
- Get the list amikacin sulphate 100 mg injectables pharma franchise suppliers & manufacturers. (rednirusmart.com)
- Nyx Pharmaceuticals is a trusted, well-known & quality oriented PCD pharma franchise or third-party manufacturing company that offers contract manufacturing services for amikacin sulphate 100 Mg injections. (rednirusmart.com)
- What are the Uses of Amikacin Sulphate Injectables in Teni? (rednirusmart.com)
- Amikacin Sulphate 250 mg Injectables are used to treat severe bacterial infections in many different body locations. (rednirusmart.com)
- How do Enquire Amikacin Sulphate Injectables Third Party Manufacturing in Teni? (rednirusmart.com)
Liposomal amikacin1
- The use of inhaled liposomal amikacin may yield improved intracellular efficacy by targeting Mabs inside the cells, while reducing its systemic toxicity. (uvsq.fr)
Infections5
- Intravenous (IV) amikacin sulfate is an aminoglycoside antibiotic typically used to treat serious infections caused by strains of Gram-negative bacteria, though it has also shown effective in staphylococcal infections. (pharmacytimes.com)
- Amikacin is a valuable aminoglycoside in serious infections. (scialert.net)
- Systemic delivery of amikacin is a widely adopted treatment modality for severe infections like sepsis. (simulations-plus.com)
- This medicine is indicated in serious infections due to amikacin sensitve gram negative organism. (dawaai.pk)
- Amikacin was selected as a proper antibiotic because it is most often used for treating severe hospital-acquired infections with multi drug resistant Gram-negative bacteria. (nanochemres.org)
Intravenously2
- When amikacin is injected intravenously, it is usually infused (injected slowly) over a period of 30 to 60 minutes. (medlineplus.gov)
- A daily dose of 2 g of sulbactam/cefoperazone plus 200 mg of amikacin or doxycycline was administered intravenously for 12.4 days (mean) in 46 patients (AlB=20/26) consisting of 27 with pneumonia (17/20), two with lung abscess (2/0), five with chronic respiratory infection (3/2) and three with sepsis (1/2). (elsevier.com)
Vitro2
- IMSEAR at SEARO: In vitro amikacin sensitivity testing. (who.int)
- In vitro combined effects of sulbactam/cefoperazone (SBT/CPZ) plus amikacin (AMK) and SBT/CPZ plus doxycycline (DOXY) against 13 strains each of clinical isolates of methicillinsusceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) and 27 strains of clinical isolates of Pseudomonas aeruginosa were evaluated. (elsevier.com)
Systemic1
- Amikacin has short half-life, which further challenges the delivery of sufficient systemic concentrations when administered by intravenous route. (simulations-plus.com)
Aminoglycoside antibiotic1
- Amikacin is a semi-synthetic aminoglycoside antibiotic that is active against a broad spectrum of Gram-negative organisms, including pseudomonas and some Gram-positive organisms (principally Staphylococcus aureus , including some methicillin-resistant strains). (guidetopharmacology.org)
Streptomycin1
- Alternatively, clofazimine, streptomycin, amikacin, or a fluoroquinolone may be used as a substitute for one of the first-line agents. (medscape.com)
Mycobacteria1
- Parenteral amikacin, as a consequence of its inability to penetrate inside the cells, is only active against extracellular mycobacteria. (uvsq.fr)
Aeruginosa1
- The current study focuses on the use of gold nanoparticles (GNPs) as a carrier to enhance the antibacterial effect of amikacin against P. aeruginosa . (nanochemres.org)
Imipenem1
- The most isolates were susceptible to ceftazidime, imipenem and amikacin. (ac.rs)
Resistance1
- Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli. (uchicago.edu)
Antibacterial activity1
- The antibacterial activity of amikacin-GNPs conjugate was investigated by disc diffusion and liquid broth dilution methods. (nanochemres.org)
Nephrotoxicity2
- This study was designed to check the effect of Nigella sativa oil and Allium sativum extract in ameliorating amikacin-induced renal damage by using a rat model of nephrotoxicity. (scialert.net)
- Rats received nephrotoxic dose of amikacin and the amelioration of amikacin-induced nephrotoxicity was assessed through microscopic lesion scoring of damaged renal tissue and estimating the changes in biomarkers of tissue damage. (scialert.net)
Cause serious kidney problems1
- Amikacin may cause serious kidney problems. (medlineplus.gov)
Efficacy2
- To solve this issue, novel delivery systems, amikacin liposomes (Ak-lip) were developed and evaluated for its antibacterial efficacy (agar plate diffusion and resazurin microtiter assay) and in vivo drug release in Sprague-Dawley rats. (simulations-plus.com)
- We conclude from the results that the efficacy of the combined chemotherapy of sulbactam/cefoperazone plus doxycycline exceeds that of sulbactam/cefoperazone plus amikacin. (elsevier.com)
Adverse effects1
- However, the current course of treatment requires repeated bolus doses of amikacin, prolonged hospitalization, and continuous therapeutic monitoring to manage the severe adverse effects. (simulations-plus.com)
Dose3
- The dosage form available for Ketoconazole / Amikacin / Triamcinolone is EZ Dose Ear Pack. (wedgewoodpharmacy.com)
- 1 strength combination of Ketoconazole / Amikacin / Triamcinolone EZ Dose Ear Pack is available. (wedgewoodpharmacy.com)
- Blood London have been providing Amikacin Level (State dose) on a self-referral basis to patients in Central and Greater London for over 20 years. (blood.london)
Isolates1
- Some isolates retained susceptibility to aztreonam (PPV-97, TS-832035, and SAP-01/99) or amikacin (PPV-108, TS-832035, and TS-832347). (cdc.gov)
Drug1
- Among the standard antimicrobial multi-drug regimens against Mabs, amikacin is considered as one of the most effective. (uvsq.fr)
Renal2
- Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of the used plant materials in reducing renal damage induced by amikacin. (scialert.net)
- By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin. (scialert.net)
Lung3
- Once you've decided to deploy the FDA-approved amikacin liposome inhaled aerosol suspension in patients with refractory MAC lung disease, how do you use to optimize patient adherence, tolerability and compliance with this treatment? (iqanda-cme.com)
- What have you learned about the role of and approach to using amikacin liposome aerosol suspension from the previous-and similar other-cases of MAC lung disease that you have managed? (iqanda-cme.com)
- Can you share a specific case that exemplifies at least one clinical phenotype with MAC lung disease that is appropriately managed with amikacin liposome inhaled suspension? (iqanda-cme.com)
Patients1
- Can you summarize the current evidence for amikacin liposome inhaled suspension, the patients in which it is appropriately deployed, and what supportive and educational measures improve toleration, adherence and durability of long-term treatment? (iqanda-cme.com)
Severe1
- The harmful effects of amikacin could be severe. (rednirusmart.com)
Treatment1
- Your doctor will order certain tests, including hearing tests, before and during treatment to check your body's response to amikacin. (medlineplus.gov)