Microbial Sensitivity Tests
Drug Resistance, Microbial
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Drug Therapy, Combination
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/633)Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin. (+info)
UK-18892, a new aminoglycoside: an in vitro study. (2/633)UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin against gentamicin-susceptible strains of Pseudomonas aeruginosa. Both amikacin and UK-18892 were equally active against gentamicin-resistant strains of P. aeruginosa. There were no appreciable differences in the activity of UK-18892 and amikacin against Enterobacteriaceae and Staphylococcus aureus. Cross-resistance between these two antimicrobials was also apparent. (+info)
Bacteriologic cure of experimental Pseudomonas keratitis. (3/633)Two long-term therapy trials with high concentrations of antibiotic were carried out to determine the duration of therapy required to achieve bacteriologic cure of experimental Pseudomonas keratitis in guinea pigs. In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml. In an 11-day trial of topical therapy with tobramycin 20 mg/ml, 34 of 36 corneas grew no Pseudomonas after 6 or more days of therapy. The bacteriologic response to therapy in this model occurred in two phases. About 99.9% or more of the organisms in the cornea were killed in the first 24 hr of therapy. The numbers of bacteria remaining in the cornea declined gradually over the next several days until the corneas were sterile. Optimal antibiotic therapy may include two stages: initial intensive therapy with high concentrations of antibiotic applied frequently to achieve a large rapid decrease in numbers of organisms in the cornea, followed by prolonged, less intensive therapy to eradicate organisms and prevent relapse. (+info)
Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (4/633)Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin. (+info)
Killing kinetics of intracellular Afipia felis treated with amikacin. (5/633)Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria. (+info)
Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (6/633)AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin. (+info)
Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. (7/633)Netilmicin (Sch 20569) is a new broad-spectrum semisynthetic aminoglycoside derived from sisomicin. Netilmicin was compared to gentamicin, tobramycin, and amikacin in a variety of in vitro test systems as well as in mouse protection tests. Netilmicin was found to be similar in activity to gentamicin against aminoglycoside-susceptible strains in both in vitro and in vivo tests. Netilmicin was also active against many aminoglycoside-resistant strains of gram-negative bacteria, particularly those known to possess adenylating enzymes (ANT 2') or those with a similar resistance pattern. Netilmicin was found to be markedly less toxic than gentamicin in chronic studies in cats, although gentamicin appeared less toxic in acute toxicity tests in mice. The concentrations of netilmicin and gentamicin in serum were compared in dogs after intramuscular dosing, and the pharmacokinetics including peak concentrations in serum were found to be similar. (+info)
Randomized prospective study comparing cost-effectiveness of teicoplanin and vancomycin as second-line empiric therapy for infection in neutropenic patients. (8/633)BACKGROUND AND OBJECTIVE: The current health-care philosophy dictates that new therapies should always be evaluated for their economic impact. Along with acquisition cost, the cost of delivery, monitoring, adverse effects and treatment failure must also be considered when determining the total cost of therapy. These auxiliary costs can be significant and greatly alter the overall cost of a drug treatment. We conducted a prospective randomized study to evaluate the efficacy, safety and cost of vancomycin and teicoplanin therapy in patients with neutropenia, after the failure of empirical treatment with a combination of piperacillin/tazobactam and amikacin. DESIGN AND METHODS: Seventy-six febrile episodes from 66 patients with hematologic malignancies under treatment, neutropenia (neutrophils <500/mm3) and fever (38 degrees C twice or 38.5 degrees C once) resistant to the combination piperacillin/tazobactam and amikacin were included in the study. RESULTS: Primary success of second-line therapy was obtained in 35 cases (46%) with no significant difference between vancomycin (17/38) and teicoplanin arms (18/38). No difference in renal or hepatic toxicity related to the antibiotic therapy was observed. The average cost per patient according to glycopeptide used was $450+/-180 for the teicoplanin group and $473+/-347 for the vancomycin group. Interestingly, in the teicoplanin arm, drug acquisition accounted for 97% of the total cost, while in the vancomycin arm administration and monitoring play an important role in overall costs. INTERPRETATION AND CONCLUSIONS: In conclusion, our pharmacoeconomic analysis demonstrates that teicoplanin and vancomycin can be administered in neutropenic hematologic patients with similar efficacy and direct costs. (+info)
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Amikacin Cost The catalog displays all strengths and sizes along with the description, imprint code, NDC and photo for each product Amikacin - lyophilized drug, 6-vial pack, 332 µg / vial: US$ 90: 215351: 6: Capreomycin - lyophilized drug, 6-vial pack, 830 µg / vial: US$ 90: 215352: 6: Ofloxacin - …. 1. Similar to other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms Similar documents cost 5-12 times as much. Sep 03, 2017 · Amikacin should not be physically premixed with other drugs but should be administered separately according to the recommended dose and route. *Retail Prices (Cash Prices) vary among pharmacies. Amikacin is potentially nephrotoxic and ototoxic and serial monitoring of serum levels provides information to maintain safe and therapeutic levels To the Editor: Multidrug-resistant tuberculosis (MDR-TB) is an increasing global problem. 5 strengths of Amikacin Injection Solution are available,
Abstract: Pharmacokinetics of Intravenous Amikacin in Intermittent Hemodialysis: Treatment of Peritoneal Dialysis Peritonitis...
Background: Data on aminoglycoside (AG) pharmacokinetics (PK) in intermittent hemodialysis (iHD) is outdated; current practice employs more efficient iHD modalities. Once-daily AG are used to optimize treatment of resistant organisms including non-tuberculous mycobacterium (NTM). Currently recommended amikacin dosing (3-5 mg/kg post-iHD) is unlikely to obtain IDSA-recommended target Cmax for NTM (20-30mg/L). Recently, experts have suggested gentamicin dosed pre-iHD can attain maximal peak to optimize PK/PD goals; using iHD to decrease overall exposure to avoid toxicity. No PK data has described pre-iHD dosing strategy for high-dose amikacin, so it remains uncommonly practiced. Methods: We describe a high-dose strategy of IV amikacin and PK monitoring (efficacy and toxicity) in 2 cases of peritoneal dialysis peritonitis caused by NTM. Amikacin was dosed at 7mg/kg on iHD days, given 4 hours pre-iHD to allow distribution. Amikacin levels were drawn: prior to iHD (peak); 4 hours post-iHD (trough); ...
In vitro potency of amikacin and comparators against E. coli, K. pneumoniae and P. aeruginosa respiratory and blood isolates |...
The purpose of this study was to define the potency of amikacin and comparator agents against a collection of blood and respiratory nosocomial isolates implicated in ICU based pulmonary infections gathered from US hospitals. Minimum inhibitory concentrations of amikacin, aztreonam, cefepime, ceftazidime, ceftolozane/tazobactam, ceftriaxone, ciprofloxacin, imipenem, meropenem, piperacillin/tazobactam and tobramycin were tested against 2460 Gram-negative isolates. Amikacin had 96 % susceptibility against the combined E. coli and K. pneumoniae isolates and 95 % susceptibility against P. aeruginosa. Ninety-six percent of all of isolates tested were susceptible (i.e., MICs ≤16 mg/L) to amikacin by current laboratory standards which demonstrates a high level of activity to combat infections caused by these organisms including ESBL, MDR, β-lactam and fluoroquinolone resistant strains. Moreover, 99 % of all organisms had amikacin MICs ≤64 mg/L. Overall, these data highlight the continued potency of
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US9333214B2 - Method for treating pulmonary disorders with liposomal amikacin formulations - Google Patents
Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.
Macular infarction after intravitreal amikacin: mounting evidence against amikacin | British Journal of Ophthalmology
Hypotheses for toxicity include dilution errors, raised post-injection intraocular pressure, concomitant use of high concentrations of subconjunctival amikacin, and variations in vitreous concentration. Local variation in concentration may play a part if the agent is directly injected into the posterior vitreous space instead of the gel itself. Another possibility for macular predilection is that this is the dependent part in the supine patient during pars plana injection.. Large studies offer alternatives to aminoglycosides on the basis of culture sensitivities.3-5, 9 Suggestions include ceftazidime, cefotaxime, and ciprofloxacin. Sensitivities of Gram negative organisms to ceftazidime range from 61% to 100% according to published studies.3-5, 9 It appears that in most studies 2 mg (0.1 ml of 20 mg/ml solution) of ceftazidime has in vitro effectiveness equipotent to or greater than 0.4 mg amikacin.3-5, 9 Primate studies have shown that intravitreal ceftazidime is non-toxic at doses of 2.25 ...
Amikacin Inj (Amikacin) dosage, indication, interactions, side effects | EMPR
Amikacin Inj (Amikacin) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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SAMU MEDIAN CO.,LTD.
Amikacin sulfate, a active ingredient of samu AMIKACIN injection, is a semi-synthetic aminoglycosides antibiotics derived from Kanamycin. Amikacin, like other aminoglycoside antibiotics, is a bactericidal agent that exerts its action at the level of bacterial ribosome. Amikacin has been shown to be effective against Gram-positive and Gram-negative bacteria, and many aminoglycoside-resistant strains due to its ability to resist degradation by aminoglycoside inactivating enzymes known to affect Gentamicin, Tobramycin and Kanamycin. Amikacin is a broad spectrum bactericidal antibiotic agent well absorbed following intravenous, subcutaneous or intramuscular injection and rapidly transmitted to skin and soft tissue, so it maintains a high therapeutic blood level. Amikacin has few side effects such as nephrotoxicity and ototoxicity ...
Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium...
TY - JOUR. T1 - Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium abscessus pulmonary disease in outpatient settings. T2 - A case series. AU - Namkoong, Ho. AU - Morimoto, Kozo. AU - Nishimura, Tomoyasu. AU - Tanaka, Hiromu. AU - Sugiura, Hiroaki. AU - Yamada, Yoshitake. AU - Kurosaki, Atsuko. AU - Asakura, Takanori. AU - Suzuki, Shoji. AU - Fujiwara, Hiroshi. AU - Yagi, Kazuma. AU - Ishii, Makoto. AU - Tasaka, Sadatomo. AU - Betsuyaku, Tomoko. AU - Hoshino, Yoshihiko. AU - Kurashima, Atsuyuki. AU - Hasegawa, Naoki. PY - 2016/8/9. Y1 - 2016/8/9. N2 - Background: Mycobacterium abscessus (M. abscessus) pulmonary disease is a refractory chronic infectious disease. Options for treating M. abscessus pulmonary disease are limited, especially in outpatient settings. Among parenteral antibiotics against M. abscessus, intravenous amikacin (AMK) is expected to be an effective outpatient antimicrobial therapy. This study ...
Defining the potency of amikacin against Escherichia coli, Klebsiella | IDR
Defining the potency of amikacin against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii derived from Chinese hospitals using CLSI and inhalation-based breakpoints Joseph L Kuti,1 Qi Wang,2 Hongbin Chen,2 Henan Li,2 Hui Wang,2 David P Nicolau1 1Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; 2Department of Clinical Laboratory, Peking University Peoples Hospital, Beijing, China Objectives: We report the in vitro activity of amikacin and comparators against Gram-negative bacteria collected from blood and respiratory specimens in China during a 1-year period between December 2015 and December 2016. Materials and methods: Minimum inhibitory concentrations (MICs) were determined by agar dilution methods using Clinical and Laboratory Standards Institute (CLSI) guidelines, and susceptibility was assessed using CLSI breakpoints, except for tigecycline against Enterobacteriaceae. A pharmacodynamic threshold MIC ≤ 256 mg/L
Amikacin (By injection)
Amikacin (a-mi-KAY-sin) Treats infections. Belongs to a class of drugs called aminoglycoside antibiotics. Brand Name(s): amikacin sulfate NovaPlus
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients...
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia : Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to the lungs.
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Amikacin is shown for the treatment of diseases brought on by powerless living beings, for example, Gram negative: amikacin is dynamic in vitro against Pseudomonas species, Escherichia coli, Proteus (indolpositivo, indolnegativo)
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Infection-Bacterial Medication for Dogs - Amikacin Polox-A-Gel Otic
Amikacin Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin preparation information is provided by Wedgewood Pharmacy.
Incidence of an aminoglycoside 6′-N-acetyltransferase, ACC (6′)-1b, in amikacin-resistant clinical isolates of gram-negative...
Summary Seventy amikacin-resistant clinical isolates of gram-negative bacteria belonging to nine genera were examined by immunoblotting and by DNA-DNA hybridisation for the presence of ACC(6′)1b enzyme, previously called AAC(6′)-4, or its encoding gene aacA1b. The organisms mostly had resistance profiles compatible with AAC(6′) production and were from South and North America, the Far East and Europe. Polyclonal (rabbit) anti-AAC(6′)-1b antisera and an intragenic aacA1b (aacA4) probe derived from the multiresistance plasmid pAZ007 were used. The aacA1b gene was found to be widespread. Positive hybridisation, and immunologically cross-reactive proteins, were observed in 44% of the isolates examined. They were present most frequently (£70%) in isolates of Klebsiella, Escherichia and Enterobacter spp., but less often (£25%) in Serratia, Citrobacter, Acinetobacter and Pseudomonas spp. The strains that reacted with the probe produced enzymes that varied in their apparent mol. wts between c. 24000
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Nebulized Ceftazidime and Amikacin in Ventilator Associated Pneumonia - Full Text View - ClinicalTrials.gov
Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics. In experimental models, nebulization of antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and increases lung bacterial killing. The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients ...
Effect of Netilmicin and Amikacin on Urinary Phospholipids Excretion in Humans | Springer for Research & Development
Lysosomal phospholipidosis of proximal tubular cells is an early index of aminoglycoside-induced nephrotoxicity and has been documented both biochemically and morphometrically in animals and humans...
Comparison of amikacin and gentamicin in the treatment of urinary - Edfromaustralia.com
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Amikacin Sulfate: Antibiotic Uses, Side Effects & Dosage
Amikacin sulfate is an antibiotic used for multiple drug-resistant bacterial infections. Learn about side effects, drug interactions, recommended dosages, and storage information.
Amikacin - Healthery
Amikacin is an antibiotic used to treat a wide variety of bacterial infections. It it often employed to treat severe infections resistant to other antibioti
Amikacin | North Bristol NHS Trust
Sample Type: Serum Test name: Amikacin Condition / Indication: Requesters have found these assays to be of value in all patients treated for ,48 hours Advance Warning: Not usually required during our core working hours (Mon - Fri 09:00 - 17:15) or Sat 09:00-12:00 for this assay. Please contact the laboratory to discuss the possibility of this assay being performed on Sundays and Bank Holidays. Sample Required: Approx. 1-2mLl of separated serum (the minimum acceptable is 100µL). Samples may be sent by post. Transport time must be ,7 days. Samples should be kept at 4°c if there is a delay in sending. Please contact laboratory if in doubt as sample integrity may be affected. Samples must be sealed and packed to conform to current regulations. Leaking samples may not be processed. Timing of Samples: We recommend a pre dose sample and a post dose sample taken 1h after end of IV/IM admin. Test Information Required: • Patient name, sex and ...
Amikacin sulfate in sodium chloride 0.9% in plastic container / amikacin sulfate NDA 064146 global drug patent coverage,...
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
Amikacin adalah salah satu obat antibiotik aminoglikosida yang memiliki fungsi membunuh dan menghambat perkembangan bakteri penyebab infeksi. Karena itu,
Empiric Use of Aminoglycosides in Hospitals | Annals of Internal Medicine | American College of Physicians
To the editor: Amikacin, a semisynthetic derivative of kanamycin A, was approved for unrestricted clinical use in 1976 and is considered the antibiotic of choice for use against infections with gentamicin-resistant, gram-negative bacilli (1, 2). In a recent issue, Betts and colleagues (3) have reported data on the use of amikacin as the primary empiric aminoglycoside in a large university hospital. The authors have concluded that because it is not possible to identify patients infected with gentamicin-resistant organisms until 48 hours after therapy is initiated, it is rational to use an antibiotic agent that is likely to be effective against ...
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File Title: Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection ...
DESCRIPTION WARNINGS Patients treated with parenteral aminoglycosides should be under close clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. Safety for treatment perio...
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This medication is used to prevent or treat a wide variety of bacterial infections. This medicine is given by an injection through a vein or a muscle as directed by the doctor. Nausea, vomiting, stomach upset, or loss of appetite may occur. as side effects. Older adults may be more sensitive to the effects of this drug, especially kidney damage. This medication may interract with amphotericin B, cidofovir, cisplatin, polymyxin B, tobramycin. Take the medicine as prescribed by the doctor and incase of an overdose, seek medical care.
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Description Mikacin 100 MG Injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci, Enterococci, etc. This medicine is known to cause serious kidney problems and hearing problems
Glomika 500 (Amikacin) Injection | Price, Usage, Dosage, and Brand Substitutes with similar Generic (Salt) Composition. -...
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Aminomeg 500 mg - (Amikacin) Injection | Price, Usage, Dosage, and Brand Substitutes with similar Generic (Salt)...
Get all details about Drug Brand Aminomeg 500 mg -, Generic Composition, Price, Manufacturer, Preparation Type, Packaging Size/Quatity/Volume and other Brands with similar Generic (Salt) Composition - www.genericdrugscan.com
This medicine is infused into a vein or injected into a muscle. It is usually given by a health care professional in a hospital or clinic setting.. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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Amikacin | Phion
Product Number , 33369880. CAS Number , 37517-28-5. EC , 253-538-5. Molecular Formula , C22H43N5O13. Molecular Weight , 585.61. Storage Temp , +4°C. Harmonized Tariff code , 29419000. Signal Word , ...
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Insmed Announces Positive Top-Line Results from Phase 3 CONVERT Study of ALIS (Amikacin Liposome Inhalation Suspension) in...
Study met primary endpoint of culture conversion (p< 0.0001)Positive top-line results from global Phase 3 controlled study in patients with NTM, a rare, progressive, destructive lung infection Company plans to pursue accelerated approval and reques
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A comparative study of in vitro activity of amikacin, gentamicin, netilmicin, tobramycin and isepamicin was done. A total of 200 clinical isolates of Gram ...
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Drugs with less than 10 isolates are removed from the chart and from the graph. The following drugs had some data removed: rifampim, amikacin. ...
Mediastinal Mass | Diagnostic Dilemma | Pediatric Oncall
A 4 months old boy presented with fever and cough for 7 days. His chest X-Ray had shown right upper and mid zone consolidation for which he had received ceftriaxone-sulbactum and amikacin for 7 days but there was no response.
Optimal Amikacin Levels for Patients with Sepsis in Intensive Care Unit of Cipto Mangunkusumo Hospital, Jakarta, Indonesia ...
TY - JOUR. T1 - Optimal Amikacin Levels for Patients with Sepsis in Intensive Care Unit of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. AU - Aliska, Gestina. AU - Setiabudy, Rianto. AU - Purwantyastuti, Purwantyastuti. AU - Karuniawati, Anis. AU - Sedono, Rudyanto. AU - Dewi, Trisni U.. AU - Azwar, Muhammad K.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - BACKGROUND: Amikacin is one of the antibiotics of choice for sepsis and septic shock. Pharmacokinetic of amikacin can be influenced by septic condition with subsequent effect on its pharmacodynamic. At Cipto Mangunkusumo Hospital (RSCM), Jakarta, adult patients in the ICU were given standard amikacin dose of 1 g/day, however the achievement of optimal plasma level had never been evaluated. This study aimed to evaluate whether the optimal plasma level of amikacin was achieved with the use of standard dose in septic conditions.METHODS: all septic patients admitted to the intensive care unit of a national tertiary hospital receiving standard dose of ...
In Vitro Elution Studies of Amikacin and Cefazolin from Polymethylmethacrylate - PHILLIPS - 2007 - Veterinary Surgery - Wiley...
Objective- To compare the in vitro elution characteristics of amikacin and cefazolin from polymethylmethacrylate (PMMA) alone and in combination.. Study Design- A prospective, controlled, experimental study.. Methods- Three aliquots of 6 g sterile PMMA were measured and to them added (1) 750 mg amikacin; (2) 1050 mg cefazolin; and (3) 750 mg amikacin and 1050 mg cefazolin. Ten beads of each antimicrobial/PMMA combination were placed in 5 mL phosphate-buffered saline (PBS) at pH 7.4 and room temperature with constant agitation. PBS was sampled at 15 time points between 1 hour and 30 days. Amikacin concentrations were determined by fluorescence polarization immunoassay and cefazolin concentrations by high-performance liquid chromatography.. Results- Amikacin and cefazolin eluted at concentrations greater than 8 and 4 times, respectively, above the minimum inhibitory concentration (MIC) for susceptible bacteria over 30 days. Co-elution of the antibiotics resulted in a greater rate and proportion of ...
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An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the...
TY - JOUR. T1 - An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring dimension RxL Max clinical chemistry system. AU - Mendu, Damodara Rao. AU - Chou, Peter P.. AU - Soldin, Steven J.. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Caffeine is widely used in childrens hospitals to treat neonatal apnea. Amikacin is used for treating hospital-acquired infections caused by Gram-negative bacteria resistant to other aminoglycosides. The blood levels, however, have to be monitored carefully because of its ototoxicity and nephrotoxicity. Methotrexate (MTX) is used as a chemotherapeutic agent in the treatment of leukemia and lymphoma as well as of certain solid tumors. Current enzyme multiplied immunoassay technique (EMIT) assays for caffeine, amikacin, and MTX lack low-end precision. In addition, the EMIT assays for MTX lack the sensitivity of reliable quantification to 0.05 μmol/L needed because of todays more rigorous ...
AMIKACIN (CAS 37517-28-5) Market Research Report 2018
AMIKACIN (CAS 37517-28-5) Market Research Report 2018 aims at providing comprehensive data on amikacin market globally and regionally (Europe, Asia,
Infection-Bacterial Medication for Dogs - Amikacin//Polymyxin B/Triamcinalone Polox-A-Gel Otic
Amikacin//Polymyxin B/Triamcinalone Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin//Polymyxin B/Triamcinalone preparation information is provided by Wedgewood Pharmacy.
Drug recall - Amikacin sulfate injection USP, 1 gram/4mL (250 mg/mL)
Announcement NORTH WALES, Pa. - Teva Pharmaceuticals today announced a voluntary recall of one lot of amikacin sulfate injection USP, 1 gram/4mL (250 m
Phase III study program with Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients...
Bayer today announced that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia, did not demonstrate superiority vers
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Prostatitis with Ecoli,amikacin and cifran right treatment ? - Doctors insight on HealthcareMagic
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Amikacin disulfate salt | Phion
Product Number , 83231030. CAS Number , 39831-55-5. EC , 254-648-6. Molecular Formula , C22H43N5O13.2H2SO4. Molecular Weight , 781.77. Storage Temp , +4°C. Harmonized Tariff code , Signal Word , ...
Structure Function Analysis for Aminoglycoside 3 Phosphotransferase II APH 3 II
Mutant strains containing APH(3)-II were constructed via site-directed mutagenesis of the cloned gene and by random mutagenesis of a strain containing the APH(3)-II gene on a conjugative plasmid. Substitutions at highly conserved amino acid residues produced APH(3) enzymes which in general showed reduced activity and conferred reduced levels of resistance to their substrates. Substitutions at Tyr 218 altered substrate specificity for the enzymes. Random mutagenesis produced plasmid-borne mutations conferring amikacin resistance. Two of these mutations appeared to be localized to the APH(3)-II structural gene ...
Novel combination of antibiotics promising against multidrug-resistant E. coli - Infectious Disease Hub
Researchers have identified that the combination of aztreonam, amikacin and polymyxin B may possess the ability to eradicate a previously immune strain of Escherichia coli, MCR1_NJ.
Narkosguiden | Infektionsbehandling - Antibiotikaval
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Two Bayer Inhaled Antibiotics Granted US FDA QIDP Designation
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ChemIDplus - 67814-76-0 - DDXRHRXGIWOVDQ-MGAUJLSLSA-L - Isepamicin sulfate [JAN] - Similar structures search, synonyms,...
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Polytechnics in Finland Higher education is provided by universities and polytechnics (ammattikorkeakoulu, AMK). The Finnish polytechnic system was buil...
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Around 16% of amikacin crosses the placenta; while the half-life of amikacin in the mother is 2 hours, it is 3.7 hours in the ... The concentration of amikacin in the renal cortex becomes ten times that of amikacin in the plasma; it then most likely ... Amikacin is derived from kanamycin A: While amikacin is only FDA-approved for use in dogs and for intrauterine infection in ... Amikacin in the eye can be accompanied by cephazolin. Despite its use there amikacin (and all aminoglycosides) are toxic to ...
M. salmoniphilum is susceptible to amikacin. Whipps CM, Butler WR, Pourahmad F, Watral VG, Kent ML. (2007). "Molecular ...
"Drug interactions between amikacin and ampicillin". Drugs.com. Archived from the original on 23 February 2018. Retrieved 22 ...
Clostridial necrotizing enteritis
... or amikacin) plus metronidazole •Ampicillin plus gentamicin (or amikacin) plus clindamycin •Ampicillin plus an expanded- ... Centers with significant gentamicin resistance patterns should consider amikacin in place of gentamicin. The use of oral ...
cefepime, ceftazidime, imipenem, meropenem or piperacillin-tazobactam; plus ciprofloxacin, levofloxacin, amikacin, gentamicin, ...
Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...
Susceptible to amikacin, azithromycin, ciprofloxacin, clarithromycin and ethambutol. Resistant to isoniazid. Differential ...
It is susceptible to amikacin, clarithromycin, and rifampin. Kim BJ, Hong SH, Yu HK, Park YG, Jeong J, Lee SH, Kim SR, Kim K, ...
M. saopaulense is susceptible to amikacin, kanamycin, and clarithromycin. Nogueira CL, Whipps CM, Matsumoto CK, Chimara E, Droz ...
Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...
The most frequently used aminoglycosides include gentamicin, amikacin and streptomycin. These antibiotics are usually used in ...
It is susceptible to amikacin, clarithromycin, ethambutol, linezolid, and rifabutin. It has also been recovered from African ...
April 2012). "Comparison of the Next-Generation Aminoglycoside Plazomicin to Gentamicin, Tobramycin and Amikacin". Expert ...
Treatment of infections after exposure to ionizing radiation
c. Third choice: gentamicin or amikacin (both aminoglycosides) +/- amoxicillin or vancomycin (all injectable). Aminoglycosides ... amikacin]) Antibiotics directed against Gram-positive bacteria need to be included in instances and institutions where ...
Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy. This ability to ...
... is antagonistic to the microbiologic effects of the antibiotics gentamicin and amikacin. The activity of rifampicin ...
A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ...
Aminoglycosides such as amikacin have been found to be very effective, as well. Quinolones can be an effective alternative. A ...
"In vivo bacterial regrowth-inhibition effect of cefbuperazone and amikacin in puerperal uterine cavity". Journal of ...
Minocycline is usually substituted when a sulfa cannot be given; high-dose imipenem and amikacin have also been used in severe ...
... gentamicin and amikacin. Intermittent fever Relapsing fever Undulant fever Remittent fever Neutropenic fever Ogoina D (August ...
"Refractory Craniofacial Actinomycetoma Due to Streptomyces somaliensis That Required Salvage Therapy with Amikacin and Imipenem ...
"Phase I Pharmacokinetics of Liposomal Amikacin (MiKasome) in Human Subjects: Dose Dependence and Urinary Clearance". Abstr ...
Sampi K, Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic ...
... kanamycin and amikacin. Reports from 2009 stated that there was a high mortality rate among the thread-sail filefish, ...
For drug-resistant TB, a combination of antibiotics such as amikacin, kanamycin, or capreomycin should be used. The most common ...
... and amikacin are the drugs most often used in clinical trials of once-daily dosing regimens. Ugeskrift for Lægerer. ... amikacin), and it is more expensive; thus, its potential value is limited. Drug Intelligence & Clinical Pharmacy: Vol. 17, No. ...
"Clofazimine Prevents the Regrowth of Mycobacterium abscessus and Mycobacterium avium Type Strains Exposed to Amikacin and ... as well as the drugs amikacin and clarithromycin. However, in the United States, clofazimine is considered an orphan drug, is ...
Antibiotics that have been used to successfully treat C. violaceum include pefloxacin, ciprofloxacin, amikacin, and co- ...
The type strain isolates were susceptible in vitro to ciprofloxacin, amikacin, tobramycin, cefoxitin, clarithromycin, ...
Amikacin Injection: MedlinePlus Drug Information
Amikacin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use amikacin injection until you finish the prescription, even if you feel better. If you stop using amikacin injection too ... Before receiving amikacin injection,. *tell your doctor and pharmacist if you are allergic to amikacin injection; other ... If you become pregnant while using amikacin injection, call your doctor immediately. Amikacin may harm the fetus. ...
Search of: 'amikacin liposome inhalation suspension' - List Results - ClinicalTrials.gov
Amikacin Injection Lots Recalled Due to Glass Particulate Presence
Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate ... Teva is recalling 7 lots of its amikacin sulfate injection 500 mg/2 mL (250 mg/mL) and 1 gram/4 mL (250 mg/mL) vials because of ... Intravenous (IV) amikacin sulfate is an aminoglycoside antibiotic typically used to treat serious infections caused by strains ... Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate ...
Ketoconazole / Amikacin / Triamcinolone EZ Dose Ear Pack
Ketoconazole / Amikacin / Triamcinolone preparation information is provided by Wedgewood Pharmacy. ... Amikacin / Triamcinolone EZ Dose Ear Pack may be prescribed for Dogs and Cats. ... Ketoconazole / Amikacin / Triamcinolone: EZ Dose Ear Pack. Ketoconazole / Amikacin / Triamcinolone may be prescribed for:. * ... 1 strength combination of Ketoconazole / Amikacin / Triamcinolone EZ Dose Ear Pack is available.*Amikacin (as Sulfate) 0.67 % ...
In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for...
Mandal, S., Mandal, M.D. & Pal, N.K. (2009). In vitro activity of gentamicin and amikacin against Salmonella enterica serovar ... In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for ... This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained ... The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 microg/mL and 0.005- ...
Amikacin - WebRef.org
WHO EMRO | In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment...
In vitro activity of gentamicin and amikacin against Salmonella enterica serovar Typhi: a search for a treatment regimen for ... There was an increase in the MIC of amikacin from 0.005 μg/mL (in 1994) to 0.25 μg/mL (in 1997), while the values ranged from ... CFU/mL for amikacin (2 µg/mL), indicating the bactericidal activity of the antibiotics against S. enterica serovar Typhi. At ... However, in our study, the MICs of gentamicin and amikacin were 0.01-4 μg/mL and 0.005-3.5 μg/mL respectively, which is even ...
The Protective Effects of Nigella sativa Oil and Allium sativum Extract on Amikacin-induced Nephrotoxicity
Rats received nephrotoxic dose of amikacin and the amelioration of amikacin-induced nephrotoxicity was assessed through ... This study was designed to check the effect of Nigella sativa oil and Allium sativum extract in ameliorating amikacin-induced ... The Protective Effects of Nigella sativa Oil and Allium sativum Extract on Amikacin-induced Nephrotoxicity. International ... Abstract: Amikacin is a valuable aminoglycoside in serious infections. However, its use is associated with undesirable renal ...
In vitro synergy between manuka honey and amikacin against Mycobacteria abscessus complex - UMF
amikacin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
AMIKACIN SULPHATE 3983-55-5;149022-22-0;39831-55-5, China AMIKACIN SULPHATE 3983-55-5;149022-22-0;39831-55-5 Manufacturers,...
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In vitro antibacterial activity and in vivo pharmacokinetics of intravenously administered Amikacin-loaded Liposomes for the...
Systemic delivery of amikacin is a widely adopted treatment modality for severe infections like sepsis. However, the current ... Amikacin has short half-life, which further challenges the delivery of sufficient systemic concentrations when administered by ... The zone of inhibition for Ak-lip and amikacin was found to be 22 mm and 26 mm against Staphylococcus aureus. The minimum ... To solve this issue, novel delivery systems, amikacin liposomes (Ak-lip) were developed and evaluated for its antibacterial ...
JCDR - Serum Amikacin Levels And Hearing In Very Low Birth Weight (VLBW) Infants
Mean peak serum amikacin level (μg/mL) was 14.5±3.16 in 7 days amikacin group; and 24.8±3.95 in 14 days amikacin group. All ... Results: Mean trough serum amikacin level (μg/ml) was 6.85±2.49 in 7 days amikacin group; and 15.2±3.41 in 14 days amikacin ... Intervention: Amikacin administration as per their setting of indication. Outcome measures: Serum amikacin levels and hearing ... Participants: 30 VLBW infants who received amikacin for 7 days, 30 VLBW infants who received amikacin for 14 days and 30 VLBW ...
Klebsiella Infections Medication: Antibiotics
Klebsiella Infections Medication: Antibiotics
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Treatment of Tuberculosis and Tuberculosis Infection in Adults and Children
Amikacin. Amikacin is highly bactericidal against M. tuberculosis in vitro. It is given as a single daily dose of 15 mg/kg by ... The major side effect of amikacin is nephrotoxicity. The dose or administration frequency of amikacin should be adjusted if ... Amikacin. Quinolones. Rifabutin. Clofazimine. Combination of beta-Lactam Antibiotics and beta-Lactamase Inhibitors. The New ... Whenever possible, amikacin concentrations in serum should be measured to assure adequate but not excessive levels. It is ...
Mycobacterium Avium Complex (MAC) (Mycobacterium Avium-Intracellulare [MAI]) Medication: Antibiotics
Alternatively, clofazimine, streptomycin, amikacin, or a fluoroquinolone may be used as a substitute for one of the first-line ... Amikacin is used for refractory cases.. Clofazimine should be avoided in patients with disseminated MAC (DMAC) infection ... Amikacin irreversibly binds to the 30S subunit of bacterial ribosomes, blocks the recognition step in protein synthesis, and ... Aerosolized amikacin for treatment of pulmonary Mycobacterium avium infections: an observational case series. BMC Pulm Med. ...
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Amikacin injection BP are manufactured, exported, and supplied by Salvavidas Pharma at the lowest price in India. Purchase ... How does Amikacin injection BP work?. In case of bacterial infection. Amikacin 250mg Injection is an injectable antibiotic that ... What if you forget to take Amikacin injection BP work?. Call your doctor if you miss a dose of Amikacin injection BP. ... Amikacin 250mg for injection is an antibiotic used to prevent or treat various bacterial infections. These include infections ...
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Arikayce (amikacin liposome inhalation) dosing, indications, interactions, adverse effects, and more
... amikacin liposome inhalation), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & ... encoded search term (amikacin liposome inhalation (Arikayce)) and amikacin liposome inhalation (Arikayce) What to Read Next on ... Animal reproductive toxicology studies have not been conducted with inhaled amikacin. *SC administration of amikacin to ... Given low systemic exposure to amikacin following administration, clinically relevant accumulation of amikacin is unlikely to ...
Amikacin EP Impurity I - Axios Research
Amikacin EP Impurity E. Synonym. (S)-4-amino-N-(((2R,3S,4S,5R,6R)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino ... Amikacin EP Impurity C. Synonym. (S)-4-amino-N-((2S,3R,4S,5S,6R)-2-(((1S,2R,3R,4S,6R)-4,6-diamino-3-(((2R,3R,4S,5S,6R)-6-( ... Amikacin EP Impurity D. Synonym. (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-(((1R,2R,3S,4R,6S)-4,6-diamino-3-(((2S,3R,4S,5S,6R)-4-amino ... Amikacin EP Impurity H. Synonym. (S)-4-amino-N-((1R,2S,3S,4R,5S)-5-amino-2-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-( ...
Amikacin Sulfate Injection Topfond Pharmaceutical Co., Ltd.
Amikacin | Medicine | Annotated Medicine and Device Lists
GentamicinLiposome inhalation suspensionInjectionInhalationTobramycinFluoroquinolones500MGMinimum inhibitory concentrationsAntibioticsKanamycinSULPHATELiposomal amikacinInfectionsIntravenouslyVitroSystemicAminoglycoside antibioticStreptomycinMycobacteriaAeruginosaImipenemResistanceAntibacterial activityNephrotoxicityCause serious kidney problemsEfficacyAdverse effectsDoseIsolatesDrugRenalLungPatientsSevereTreatment
- This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained from blood of patients clinically suspected of enteric fever who attended the Calcutta School of Tropical Medicine from 1991 to 2003. (who.int)
- The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 microg/mL and 0.005-3.5 microg/mL respectively. (who.int)
- The same principles of drug monitoring for gentamicin apply to amikacin. (medscape.com)
- Amikacin and gentamicin find maximum usage in veterinary medicine. (grandviewresearch.com)
- Amikacin (100%), imipenem (94.7%), ciprofloxacin (68.4%), and gentamicin (63.1%) were the most effective antibiotics against Staph. (qscience.com)
Liposome inhalation suspension1
- When intensification of therapy with amikacin is being considered, or has been implemented in patients, how do you differentiate between and/or decide to initiate therapy with the IV vs. amikacin liposome inhalation suspension formulation? (iqanda-cme.com)
- Your doctor may not want you to receive amikacin injection. (medlineplus.gov)
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection. (medlineplus.gov)
- Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (medlineplus.gov)
- Amikacin injection is in a class of medications called aminoglycoside antibiotics. (medlineplus.gov)
- Antibiotics such as amikacin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). (medlineplus.gov)
- You may receive amikacin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
- If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with amikacin injection. (medlineplus.gov)
- Use amikacin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
- If you stop using amikacin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- or any of the ingredients in amikacin injection. (medlineplus.gov)
- Teva is recalling 7 lots of its amikacin sulfate injection and vials because of the potential presence of glass particulate matter. (pharmacytimes.com)
- How does Amikacin injection BP work? (salvavidaspharma.com)
- Amikacin 250mg Injection is an injectable antibiotic that stops the growth of bacteria that cause infections in the body. (salvavidaspharma.com)
- What if you forget to take Amikacin injection BP work? (salvavidaspharma.com)
- Call your doctor if you miss a dose of Amikacin injection BP. (salvavidaspharma.com)
- Amikacin 250mg for injection is an antibiotic used to prevent or treat various bacterial infections. (salvavidaspharma.com)
- Amikacin Sulfate Injection_Topfond Pharmaceutical Co., Ltd. (topfond.com)
- Amikacin is an injection antibacterial used to treat serious infections. (insheal.in)
- Mikacin 250 MG Injection (Amikacin Injection) is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci, Enterococci, etc. (genericonlinemeds.com)
- Amikacin Injection is known to cause serious kidney problems and hearing problems, especially in the elderly population. (genericonlinemeds.com)
- Amikacin Sulphate Injection is an antibiotic used to prevent or treat a wide variety of bacterial infections. (rednirusmart.com)
- Amikacin Sulphate Injection works by stopping the growth of bacteria It should not be self-administered and is provided via drip (intravenous infusion) or injection into a vein or muscle under the guidance of a medical practitioner. (rednirusmart.com)
- If you want to manufacture your own Amikacin Sulphate 250 mg Injection brand in third party then find the contact details of the WHO and GMP certified third party manufactures in Teni. (rednirusmart.com)
- How many Amikacin Sulphate Injection Manufacturing Companies associated with Rednirus Mart in Teni? (rednirusmart.com)
- There are approxx 50+ Amikacin Sulphate injection third party pharma manufacturing companies listed on our online b2b pharmaceutical marketplace like Janus Biotech, SNU Biocare, SP Pharmaceutical and many more. (rednirusmart.com)
- This fact sheet is a step-by-step guideline discussing the supplies required, limitations and precautions, pharmacokinetics, proper storage, and accurate placement for injection of Amikacin with picture guides. (cdc.gov)
- amikacin liposome inhalation increases effects of abobotulinumtoxinA by pharmacodynamic synergism. (medscape.com)
- sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of amikacin liposome inhalation by Other (see comment). (medscape.com)
- Objectives To evaluate the colocalization of an amikacin liposomal inhalation suspension (ALIS) with intracellular Mabs, and then to measure its intracellular anti-Mabs activity. (uvsq.fr)
- Insmed is planning to commence a Phase 2 clinical trial of Arikace (liposomal amikacin for inhalation) in patients with non-tuberculous mycobacteria (NTM) lung disease, and an European registration Phase 3 study in Cystic Fibrosis (CF) patients with Pseudomonas aeruginosa (Pa) lung infections. (clinicaltrialsarena.com)
- Consequently, analysis focused on pentamidine, classified by NIOSH as a hazardous drug, and the antibiotics amikacin, colistin, and tobramycin, which currently lack authoritative safe handling guidelines. (cdc.gov)
- The Xpert MTB/XDR assay was used as a reflex test to detect resistance to isoniazid , fluoroquinolones , ethionamide , amikacin , kanamycin , and capreomycin in adults with positive results for Mycobacterium tuberculosis complex on Xpert MTB/RIF or Ultra (Cepheid). (bvsalud.org)
- Amikacin 500mg Inj. (dawaai.pk)
Minimum inhibitory concentrations1
- The minimum inhibitory concentrations (MIC) of amikacin and Ak-lip against Staphylococcus aureus were found to be 3 µg/mL and 9 µg/mL, and for Pseudomonas aeruginosa were 0.6 µg/mL and 0.9 µg/mL respectively. (simulations-plus.com)
- The group of drugs known as aminoglycoside antibiotics includes amikacin. (rednirusmart.com)
- Detection of isoniazid, fluoroquinolone, ethionamide, amikacin, kanamycin, and capreomycin resistance by the Xpert MTB/XDR assay: a cross-sectional multicentre diagnostic accuracy study. (bvsalud.org)
- Aminoglycosides used in the treatment of MDR-TB include kanamycin capreomycin, and amikacin. (grandviewresearch.com)
- Use of kanamycin in MDR-TB is recommended after failure of capreomycin but before treatment with amikacin However, presence of substitutes such as amikacin is expected to restrain kanamycin demand as amikacin was found to be more effective at critical concentration as compared to capreomycin and kanamycin on testing their efficacies on the wild-type M. tuberculosis. (grandviewresearch.com)
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- Amikacin Sulphate 100 Mg Injectables Pharma Franchise Suppliers & Manu. (rednirusmart.com)
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- Nyx Pharmaceuticals is a trusted, well-known & quality oriented PCD pharma franchise or third-party manufacturing company that offers contract manufacturing services for amikacin sulphate 100 Mg injections. (rednirusmart.com)
- What are the Uses of Amikacin Sulphate Injectables in Teni? (rednirusmart.com)
- Amikacin Sulphate 250 mg Injectables are used to treat severe bacterial infections in many different body locations. (rednirusmart.com)
- How do Enquire Amikacin Sulphate Injectables Third Party Manufacturing in Teni? (rednirusmart.com)
- The use of inhaled liposomal amikacin may yield improved intracellular efficacy by targeting Mabs inside the cells, while reducing its systemic toxicity. (uvsq.fr)
- Intravenous (IV) amikacin sulfate is an aminoglycoside antibiotic typically used to treat serious infections caused by strains of Gram-negative bacteria, though it has also shown effective in staphylococcal infections. (pharmacytimes.com)
- Amikacin is a valuable aminoglycoside in serious infections. (scialert.net)
- Systemic delivery of amikacin is a widely adopted treatment modality for severe infections like sepsis. (simulations-plus.com)
- This medicine is indicated in serious infections due to amikacin sensitve gram negative organism. (dawaai.pk)
- Amikacin was selected as a proper antibiotic because it is most often used for treating severe hospital-acquired infections with multi drug resistant Gram-negative bacteria. (nanochemres.org)
- When amikacin is injected intravenously, it is usually infused (injected slowly) over a period of 30 to 60 minutes. (medlineplus.gov)
- A daily dose of 2 g of sulbactam/cefoperazone plus 200 mg of amikacin or doxycycline was administered intravenously for 12.4 days (mean) in 46 patients (AlB=20/26) consisting of 27 with pneumonia (17/20), two with lung abscess (2/0), five with chronic respiratory infection (3/2) and three with sepsis (1/2). (elsevier.com)
- IMSEAR at SEARO: In vitro amikacin sensitivity testing. (who.int)
- In vitro combined effects of sulbactam/cefoperazone (SBT/CPZ) plus amikacin (AMK) and SBT/CPZ plus doxycycline (DOXY) against 13 strains each of clinical isolates of methicillinsusceptible Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) and 27 strains of clinical isolates of Pseudomonas aeruginosa were evaluated. (elsevier.com)
- Amikacin has short half-life, which further challenges the delivery of sufficient systemic concentrations when administered by intravenous route. (simulations-plus.com)
- Amikacin is a semi-synthetic aminoglycoside antibiotic that is active against a broad spectrum of Gram-negative organisms, including pseudomonas and some Gram-positive organisms (principally Staphylococcus aureus , including some methicillin-resistant strains). (guidetopharmacology.org)
- Alternatively, clofazimine, streptomycin, amikacin, or a fluoroquinolone may be used as a substitute for one of the first-line agents. (medscape.com)
- Parenteral amikacin, as a consequence of its inability to penetrate inside the cells, is only active against extracellular mycobacteria. (uvsq.fr)
- The current study focuses on the use of gold nanoparticles (GNPs) as a carrier to enhance the antibacterial effect of amikacin against P. aeruginosa . (nanochemres.org)
- The most isolates were susceptible to ceftazidime, imipenem and amikacin. (ac.rs)
- Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli. (uchicago.edu)
- The antibacterial activity of amikacin-GNPs conjugate was investigated by disc diffusion and liquid broth dilution methods. (nanochemres.org)
- This study was designed to check the effect of Nigella sativa oil and Allium sativum extract in ameliorating amikacin-induced renal damage by using a rat model of nephrotoxicity. (scialert.net)
- Rats received nephrotoxic dose of amikacin and the amelioration of amikacin-induced nephrotoxicity was assessed through microscopic lesion scoring of damaged renal tissue and estimating the changes in biomarkers of tissue damage. (scialert.net)
Cause serious kidney problems1
- Amikacin may cause serious kidney problems. (medlineplus.gov)
- To solve this issue, novel delivery systems, amikacin liposomes (Ak-lip) were developed and evaluated for its antibacterial efficacy (agar plate diffusion and resazurin microtiter assay) and in vivo drug release in Sprague-Dawley rats. (simulations-plus.com)
- We conclude from the results that the efficacy of the combined chemotherapy of sulbactam/cefoperazone plus doxycycline exceeds that of sulbactam/cefoperazone plus amikacin. (elsevier.com)
- However, the current course of treatment requires repeated bolus doses of amikacin, prolonged hospitalization, and continuous therapeutic monitoring to manage the severe adverse effects. (simulations-plus.com)
- The dosage form available for Ketoconazole / Amikacin / Triamcinolone is EZ Dose Ear Pack. (wedgewoodpharmacy.com)
- 1 strength combination of Ketoconazole / Amikacin / Triamcinolone EZ Dose Ear Pack is available. (wedgewoodpharmacy.com)
- Blood London have been providing Amikacin Level (State dose) on a self-referral basis to patients in Central and Greater London for over 20 years. (blood.london)
- Some isolates retained susceptibility to aztreonam (PPV-97, TS-832035, and SAP-01/99) or amikacin (PPV-108, TS-832035, and TS-832347). (cdc.gov)
- Among the standard antimicrobial multi-drug regimens against Mabs, amikacin is considered as one of the most effective. (uvsq.fr)
- Semi-quantitative analysis of cellular infiltration, necrosis of tubular cells and tubular cellular damage indicated the protective effect of the used plant materials in reducing renal damage induced by amikacin. (scialert.net)
- By using a rat model, Nigella sativa oil and Allium sativum extract efficiently ameliorated the renal toxic effect of amikacin. (scialert.net)
- Once you've decided to deploy the FDA-approved amikacin liposome inhaled aerosol suspension in patients with refractory MAC lung disease, how do you use to optimize patient adherence, tolerability and compliance with this treatment? (iqanda-cme.com)
- What have you learned about the role of and approach to using amikacin liposome aerosol suspension from the previous-and similar other-cases of MAC lung disease that you have managed? (iqanda-cme.com)
- Can you share a specific case that exemplifies at least one clinical phenotype with MAC lung disease that is appropriately managed with amikacin liposome inhaled suspension? (iqanda-cme.com)
- Can you summarize the current evidence for amikacin liposome inhaled suspension, the patients in which it is appropriately deployed, and what supportive and educational measures improve toleration, adherence and durability of long-term treatment? (iqanda-cme.com)
- The harmful effects of amikacin could be severe. (rednirusmart.com)
- Your doctor will order certain tests, including hearing tests, before and during treatment to check your body's response to amikacin. (medlineplus.gov)