A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
Substances that reduce the growth or reproduction of BACTERIA.
Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.
An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.
Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.
Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray's Anatomy, 30th American ed, p1328, 1332)
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.
A class of enzymes that inactivate aminocyclitol-aminoglycoside antibiotics (AMINOGLYCOSIDES) by regiospecific PHOSPHORYLATION of the 3' and/or 5' hydroxyl.
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Therapy with two or more separate preparations given for a combined effect.
The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)
A cephalosporin antibiotic.
Infections with bacteria of the genus PSEUDOMONAS.
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the natural environment (soil, water, and plant surfaces) or as an opportunistic human pathogen.
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
Simultaneous resistance to several structurally and functionally distinct drugs.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Infections by bacteria, general or unspecified.
A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.
Types of prosthetic joints in which both wear surfaces of the joint coupling are metallic.
Replacement for a hip joint.
A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Replacement of the hip joint.
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/633)

Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.  (+info)

UK-18892, a new aminoglycoside: an in vitro study. (2/633)

UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin against gentamicin-susceptible strains of Pseudomonas aeruginosa. Both amikacin and UK-18892 were equally active against gentamicin-resistant strains of P. aeruginosa. There were no appreciable differences in the activity of UK-18892 and amikacin against Enterobacteriaceae and Staphylococcus aureus. Cross-resistance between these two antimicrobials was also apparent.  (+info)

Bacteriologic cure of experimental Pseudomonas keratitis. (3/633)

Two long-term therapy trials with high concentrations of antibiotic were carried out to determine the duration of therapy required to achieve bacteriologic cure of experimental Pseudomonas keratitis in guinea pigs. In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml. In an 11-day trial of topical therapy with tobramycin 20 mg/ml, 34 of 36 corneas grew no Pseudomonas after 6 or more days of therapy. The bacteriologic response to therapy in this model occurred in two phases. About 99.9% or more of the organisms in the cornea were killed in the first 24 hr of therapy. The numbers of bacteria remaining in the cornea declined gradually over the next several days until the corneas were sterile. Optimal antibiotic therapy may include two stages: initial intensive therapy with high concentrations of antibiotic applied frequently to achieve a large rapid decrease in numbers of organisms in the cornea, followed by prolonged, less intensive therapy to eradicate organisms and prevent relapse.  (+info)

Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (4/633)

Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin.  (+info)

Killing kinetics of intracellular Afipia felis treated with amikacin. (5/633)

Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria.  (+info)

Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (6/633)

AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin.  (+info)

Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. (7/633)

Netilmicin (Sch 20569) is a new broad-spectrum semisynthetic aminoglycoside derived from sisomicin. Netilmicin was compared to gentamicin, tobramycin, and amikacin in a variety of in vitro test systems as well as in mouse protection tests. Netilmicin was found to be similar in activity to gentamicin against aminoglycoside-susceptible strains in both in vitro and in vivo tests. Netilmicin was also active against many aminoglycoside-resistant strains of gram-negative bacteria, particularly those known to possess adenylating enzymes (ANT 2') or those with a similar resistance pattern. Netilmicin was found to be markedly less toxic than gentamicin in chronic studies in cats, although gentamicin appeared less toxic in acute toxicity tests in mice. The concentrations of netilmicin and gentamicin in serum were compared in dogs after intramuscular dosing, and the pharmacokinetics including peak concentrations in serum were found to be similar.  (+info)

Randomized prospective study comparing cost-effectiveness of teicoplanin and vancomycin as second-line empiric therapy for infection in neutropenic patients. (8/633)

BACKGROUND AND OBJECTIVE: The current health-care philosophy dictates that new therapies should always be evaluated for their economic impact. Along with acquisition cost, the cost of delivery, monitoring, adverse effects and treatment failure must also be considered when determining the total cost of therapy. These auxiliary costs can be significant and greatly alter the overall cost of a drug treatment. We conducted a prospective randomized study to evaluate the efficacy, safety and cost of vancomycin and teicoplanin therapy in patients with neutropenia, after the failure of empirical treatment with a combination of piperacillin/tazobactam and amikacin. DESIGN AND METHODS: Seventy-six febrile episodes from 66 patients with hematologic malignancies under treatment, neutropenia (neutrophils <500/mm3) and fever (38 degrees C twice or 38.5 degrees C once) resistant to the combination piperacillin/tazobactam and amikacin were included in the study. RESULTS: Primary success of second-line therapy was obtained in 35 cases (46%) with no significant difference between vancomycin (17/38) and teicoplanin arms (18/38). No difference in renal or hepatic toxicity related to the antibiotic therapy was observed. The average cost per patient according to glycopeptide used was $450+/-180 for the teicoplanin group and $473+/-347 for the vancomycin group. Interestingly, in the teicoplanin arm, drug acquisition accounted for 97% of the total cost, while in the vancomycin arm administration and monitoring play an important role in overall costs. INTERPRETATION AND CONCLUSIONS: In conclusion, our pharmacoeconomic analysis demonstrates that teicoplanin and vancomycin can be administered in neutropenic hematologic patients with similar efficacy and direct costs.  (+info)

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Amikacin Cost The catalog displays all strengths and sizes along with the description, imprint code, NDC and photo for each product Amikacin - lyophilized drug, 6-vial pack, 332 µg / vial: US$ 90: 215351: 6: Capreomycin - lyophilized drug, 6-vial pack, 830 µg / vial: US$ 90: 215352: 6: Ofloxacin - …. 1. Similar to other aminoglycosides, amikacin disrupts bacterial protein synthesis by binding to the 30S ribosome of susceptible organisms Similar documents cost 5-12 times as much. Sep 03, 2017 · Amikacin should not be physically premixed with other drugs but should be administered separately according to the recommended dose and route. *Retail Prices (Cash Prices) vary among pharmacies. Amikacin is potentially nephrotoxic and ototoxic and serial monitoring of serum levels provides information to maintain safe and therapeutic levels To the Editor: Multidrug-resistant tuberculosis (MDR-TB) is an increasing global problem. 5 strengths of Amikacin Injection Solution are available,
Background: Data on aminoglycoside (AG) pharmacokinetics (PK) in intermittent hemodialysis (iHD) is outdated; current practice employs more efficient iHD modalities. Once-daily AG are used to optimize treatment of resistant organisms including non-tuberculous mycobacterium (NTM). Currently recommended amikacin dosing (3-5 mg/kg post-iHD) is unlikely to obtain IDSA-recommended target Cmax for NTM (20-30mg/L). Recently, experts have suggested gentamicin dosed pre-iHD can attain maximal peak to optimize PK/PD goals; using iHD to decrease overall exposure to avoid toxicity. No PK data has described pre-iHD dosing strategy for high-dose amikacin, so it remains uncommonly practiced. Methods: We describe a high-dose strategy of IV amikacin and PK monitoring (efficacy and toxicity) in 2 cases of peritoneal dialysis peritonitis caused by NTM. Amikacin was dosed at 7mg/kg on iHD days, given 4 hours pre-iHD to allow distribution. Amikacin levels were drawn: prior to iHD (peak); 4 hours post-iHD (trough); ...
The purpose of this study was to define the potency of amikacin and comparator agents against a collection of blood and respiratory nosocomial isolates implicated in ICU based pulmonary infections gathered from US hospitals. Minimum inhibitory concentrations of amikacin, aztreonam, cefepime, ceftazidime, ceftolozane/tazobactam, ceftriaxone, ciprofloxacin, imipenem, meropenem, piperacillin/tazobactam and tobramycin were tested against 2460 Gram-negative isolates. Amikacin had 96 % susceptibility against the combined E. coli and K. pneumoniae isolates and 95 % susceptibility against P. aeruginosa. Ninety-six percent of all of isolates tested were susceptible (i.e., MICs ≤16 mg/L) to amikacin by current laboratory standards which demonstrates a high level of activity to combat infections caused by these organisms including ESBL, MDR, β-lactam and fluoroquinolone resistant strains. Moreover, 99 % of all organisms had amikacin MICs ≤64 mg/L. Overall, these data highlight the continued potency of
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Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.
Hypotheses for toxicity include dilution errors, raised post-injection intraocular pressure, concomitant use of high concentrations of subconjunctival amikacin, and variations in vitreous concentration. Local variation in concentration may play a part if the agent is directly injected into the posterior vitreous space instead of the gel itself. Another possibility for macular predilection is that this is the dependent part in the supine patient during pars plana injection.. Large studies offer alternatives to aminoglycosides on the basis of culture sensitivities.3-5, 9 Suggestions include ceftazidime, cefotaxime, and ciprofloxacin. Sensitivities of Gram negative organisms to ceftazidime range from 61% to 100% according to published studies.3-5, 9 It appears that in most studies 2 mg (0.1 ml of 20 mg/ml solution) of ceftazidime has in vitro effectiveness equipotent to or greater than 0.4 mg amikacin.3-5, 9 Primate studies have shown that intravitreal ceftazidime is non-toxic at doses of 2.25 ...
Amikacin Inj (Amikacin) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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Amikacin sulfate, a active ingredient of samu AMIKACIN injection, is a semi-synthetic aminoglycosides antibiotics derived from Kanamycin. Amikacin, like other aminoglycoside antibiotics, is a bactericidal agent that exerts its action at the level of bacterial ribosome. Amikacin has been shown to be effective against Gram-positive and Gram-negative bacteria, and many aminoglycoside-resistant strains due to its ability to resist degradation by aminoglycoside inactivating enzymes known to affect Gentamicin, Tobramycin and Kanamycin. Amikacin is a broad spectrum bactericidal antibiotic agent well absorbed following intravenous, subcutaneous or intramuscular injection and rapidly transmitted to skin and soft tissue, so it maintains a high therapeutic blood level. Amikacin has few side effects such as nephrotoxicity and ototoxicity ...
TY - JOUR. T1 - Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium abscessus pulmonary disease in outpatient settings. T2 - A case series. AU - Namkoong, Ho. AU - Morimoto, Kozo. AU - Nishimura, Tomoyasu. AU - Tanaka, Hiromu. AU - Sugiura, Hiroaki. AU - Yamada, Yoshitake. AU - Kurosaki, Atsuko. AU - Asakura, Takanori. AU - Suzuki, Shoji. AU - Fujiwara, Hiroshi. AU - Yagi, Kazuma. AU - Ishii, Makoto. AU - Tasaka, Sadatomo. AU - Betsuyaku, Tomoko. AU - Hoshino, Yoshihiko. AU - Kurashima, Atsuyuki. AU - Hasegawa, Naoki. PY - 2016/8/9. Y1 - 2016/8/9. N2 - Background: Mycobacterium abscessus (M. abscessus) pulmonary disease is a refractory chronic infectious disease. Options for treating M. abscessus pulmonary disease are limited, especially in outpatient settings. Among parenteral antibiotics against M. abscessus, intravenous amikacin (AMK) is expected to be an effective outpatient antimicrobial therapy. This study ...
Defining the potency of amikacin against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii derived from Chinese hospitals using CLSI and inhalation-based breakpoints Joseph L Kuti,1 Qi Wang,2 Hongbin Chen,2 Henan Li,2 Hui Wang,2 David P Nicolau1 1Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA; 2Department of Clinical Laboratory, Peking University Peoples Hospital, Beijing, China Objectives: We report the in vitro activity of amikacin and comparators against Gram-negative bacteria collected from blood and respiratory specimens in China during a 1-year period between December 2015 and December 2016. Materials and methods: Minimum inhibitory concentrations (MICs) were determined by agar dilution methods using Clinical and Laboratory Standards Institute (CLSI) guidelines, and susceptibility was assessed using CLSI breakpoints, except for tigecycline against Enterobacteriaceae. A pharmacodynamic threshold MIC ≤ 256 mg/L
Amikacin (a-mi-KAY-sin) Treats infections. Belongs to a class of drugs called aminoglycoside antibiotics. Brand Name(s): amikacin sulfate NovaPlus
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia : Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to the lungs.
Amikacin is shown for the treatment of diseases brought on by powerless living beings, for example, Gram negative: amikacin is dynamic in vitro against Pseudomonas species, Escherichia coli, Proteus (indolpositivo, indolnegativo)
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Amikacin Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin preparation information is provided by Wedgewood Pharmacy.
Summary Seventy amikacin-resistant clinical isolates of gram-negative bacteria belonging to nine genera were examined by immunoblotting and by DNA-DNA hybridisation for the presence of ACC(6′)1b enzyme, previously called AAC(6′)-4, or its encoding gene aacA1b. The organisms mostly had resistance profiles compatible with AAC(6′) production and were from South and North America, the Far East and Europe. Polyclonal (rabbit) anti-AAC(6′)-1b antisera and an intragenic aacA1b (aacA4) probe derived from the multiresistance plasmid pAZ007 were used. The aacA1b gene was found to be widespread. Positive hybridisation, and immunologically cross-reactive proteins, were observed in 44% of the isolates examined. They were present most frequently (£70%) in isolates of Klebsiella, Escherichia and Enterobacter spp., but less often (£25%) in Serratia, Citrobacter, Acinetobacter and Pseudomonas spp. The strains that reacted with the probe produced enzymes that varied in their apparent mol. wts between c. 24000
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Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics. In experimental models, nebulization of antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and increases lung bacterial killing. The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients ...
Lysosomal phospholipidosis of proximal tubular cells is an early index of aminoglycoside-induced nephrotoxicity and has been documented both biochemically and morphometrically in animals and humans...
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Amikacin sulfate is an antibiotic used for multiple drug-resistant bacterial infections. Learn about side effects, drug interactions, recommended dosages, and storage information.
Amikacin is an antibiotic used to treat a wide variety of bacterial infections. It it often employed to treat severe infections resistant to other antibioti
Sample Type: Serum Test name: Amikacin Condition / Indication: Requesters have found these assays to be of value in all patients treated for ,48 hours Advance Warning: Not usually required during our core working hours (Mon - Fri 09:00 - 17:15) or Sat 09:00-12:00 for this assay. Please contact the laboratory to discuss the possibility of this assay being performed on Sundays and Bank Holidays. Sample Required: Approx. 1-2mLl of separated serum (the minimum acceptable is 100µL). Samples may be sent by post. Transport time must be ,7 days. Samples should be kept at 4°c if there is a delay in sending. Please contact laboratory if in doubt as sample integrity may be affected. Samples must be sealed and packed to conform to current regulations. Leaking samples may not be processed. Timing of Samples: We recommend a pre dose sample and a post dose sample taken 1h after end of IV/IM admin. Test Information Required: • Patient name, sex and ...
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Amikacin adalah salah satu obat antibiotik aminoglikosida yang memiliki fungsi membunuh dan menghambat perkembangan bakteri penyebab infeksi. Karena itu,
To the editor: Amikacin, a semisynthetic derivative of kanamycin A, was approved for unrestricted clinical use in 1976 and is considered the antibiotic of choice for use against infections with gentamicin-resistant, gram-negative bacilli (1, 2). In a recent issue, Betts and colleagues (3) have reported data on the use of amikacin as the primary empiric aminoglycoside in a large university hospital. The authors have concluded that because it is not possible to identify patients infected with gentamicin-resistant organisms until 48 hours after therapy is initiated, it is rational to use an antibiotic agent that is likely to be effective against ...
File Title: Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection ...
DESCRIPTION WARNINGS Patients treated with parenteral aminoglycosides should be under close clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. Safety for treatment perio...
This medication is used to prevent or treat a wide variety of bacterial infections. This medicine is given by an injection through a vein or a muscle as directed by the doctor. Nausea, vomiting, stomach upset, or loss of appetite may occur. as side effects. Older adults may be more sensitive to the effects of this drug, especially kidney damage. This medication may interract with amphotericin B, cidofovir, cisplatin, polymyxin B, tobramycin. Take the medicine as prescribed by the doctor and incase of an overdose, seek medical care.
Description Mikacin 100 MG Injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci, Enterococci, etc. This medicine is known to cause serious kidney problems and hearing problems
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This medicine is infused into a vein or injected into a muscle. It is usually given by a health care professional in a hospital or clinic setting.. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl ]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-3-hydroxy-cyclo hexyl]-2-hydroxy- ...
4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl ]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-3-hydroxy-cyclo hexyl]-2-hydroxy- ...
Product Number , 33369880. CAS Number , 37517-28-5. EC , 253-538-5. Molecular Formula , C22H43N5O13. Molecular Weight , 585.61. Storage Temp , +4°C. Harmonized Tariff code , 29419000. Signal Word , ...
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Study met primary endpoint of culture conversion (p< 0.0001)Positive top-line results from global Phase 3 controlled study in patients with NTM, a rare, progressive, destructive lung infection Company plans to pursue accelerated approval and reques
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A comparative study of in vitro activity of amikacin, gentamicin, netilmicin, tobramycin and isepamicin was done. A total of 200 clinical isolates of Gram ...
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Drugs with less than 10 isolates are removed from the chart and from the graph. The following drugs had some data removed: rifampim, amikacin. ...
A 4 months old boy presented with fever and cough for 7 days. His chest X-Ray had shown right upper and mid zone consolidation for which he had received ceftriaxone-sulbactum and amikacin for 7 days but there was no response.
TY - JOUR. T1 - Optimal Amikacin Levels for Patients with Sepsis in Intensive Care Unit of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. AU - Aliska, Gestina. AU - Setiabudy, Rianto. AU - Purwantyastuti, Purwantyastuti. AU - Karuniawati, Anis. AU - Sedono, Rudyanto. AU - Dewi, Trisni U.. AU - Azwar, Muhammad K.. PY - 2017/7/1. Y1 - 2017/7/1. N2 - BACKGROUND: Amikacin is one of the antibiotics of choice for sepsis and septic shock. Pharmacokinetic of amikacin can be influenced by septic condition with subsequent effect on its pharmacodynamic. At Cipto Mangunkusumo Hospital (RSCM), Jakarta, adult patients in the ICU were given standard amikacin dose of 1 g/day, however the achievement of optimal plasma level had never been evaluated. This study aimed to evaluate whether the optimal plasma level of amikacin was achieved with the use of standard dose in septic conditions.METHODS: all septic patients admitted to the intensive care unit of a national tertiary hospital receiving standard dose of ...
Objective- To compare the in vitro elution characteristics of amikacin and cefazolin from polymethylmethacrylate (PMMA) alone and in combination.. Study Design- A prospective, controlled, experimental study.. Methods- Three aliquots of 6 g sterile PMMA were measured and to them added (1) 750 mg amikacin; (2) 1050 mg cefazolin; and (3) 750 mg amikacin and 1050 mg cefazolin. Ten beads of each antimicrobial/PMMA combination were placed in 5 mL phosphate-buffered saline (PBS) at pH 7.4 and room temperature with constant agitation. PBS was sampled at 15 time points between 1 hour and 30 days. Amikacin concentrations were determined by fluorescence polarization immunoassay and cefazolin concentrations by high-performance liquid chromatography.. Results- Amikacin and cefazolin eluted at concentrations greater than 8 and 4 times, respectively, above the minimum inhibitory concentration (MIC) for susceptible bacteria over 30 days. Co-elution of the antibiotics resulted in a greater rate and proportion of ...
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TY - JOUR. T1 - An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring dimension RxL Max clinical chemistry system. AU - Mendu, Damodara Rao. AU - Chou, Peter P.. AU - Soldin, Steven J.. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Caffeine is widely used in childrens hospitals to treat neonatal apnea. Amikacin is used for treating hospital-acquired infections caused by Gram-negative bacteria resistant to other aminoglycosides. The blood levels, however, have to be monitored carefully because of its ototoxicity and nephrotoxicity. Methotrexate (MTX) is used as a chemotherapeutic agent in the treatment of leukemia and lymphoma as well as of certain solid tumors. Current enzyme multiplied immunoassay technique (EMIT) assays for caffeine, amikacin, and MTX lack low-end precision. In addition, the EMIT assays for MTX lack the sensitivity of reliable quantification to 0.05 μmol/L needed because of todays more rigorous ...
AMIKACIN (CAS 37517-28-5) Market Research Report 2018 aims at providing comprehensive data on amikacin market globally and regionally (Europe, Asia,
Amikacin//Polymyxin B/Triamcinalone Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin//Polymyxin B/Triamcinalone preparation information is provided by Wedgewood Pharmacy.
Bayer today announced that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia, did not demonstrate superiority vers
Drug information on brand Kacin (100mg) 100mg/1vial (1Vial Injection) (Amikacin). It is manufactured by Modern Laboratories. Find out its price,dose and the nearest pharmacy to buy it.
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Question - Prostatitis with Ecoli,amikacin and cifran right treatment ?. Ask a Doctor about diagnosis, treatment and medication for Chronic prostatitis, Ask a Urologist
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Product Number , 83231030. CAS Number , 39831-55-5. EC , 254-648-6. Molecular Formula , C22H43N5O13.2H2SO4. Molecular Weight , 781.77. Storage Temp , +4°C. Harmonized Tariff code , Signal Word , ...
Mutant strains containing APH(3)-II were constructed via site-directed mutagenesis of the cloned gene and by random mutagenesis of a strain containing the APH(3)-II gene on a conjugative plasmid. Substitutions at highly conserved amino acid residues produced APH(3) enzymes which in general showed reduced activity and conferred reduced levels of resistance to their substrates. Substitutions at Tyr 218 altered substrate specificity for the enzymes. Random mutagenesis produced plasmid-borne mutations conferring amikacin resistance. Two of these mutations appeared to be localized to the APH(3)-II structural gene ...
Researchers have identified that the combination of aztreonam, amikacin and polymyxin B may possess the ability to eradicate a previously immune strain of Escherichia coli, MCR1_NJ.
OBS! Ta alltid odlingsprov från relevanta lokaler innan antibiotikabehandling påbörjas, till exempel blod, sputum, sår och urin.. Vid svår sepsis tillägg av Nebcina under första dygnet i dosen 5-7 mg/kg×1 om Kreatinin-clearance ,80; 4,5-2,2 mg/kg×1 om Kreatinin-clearance 80-41; 2,2-1 mg/kg×1 om Kreatinin-clearance 40-20; vikt ~ lean body mass. Serumkonc. av tobramycin, som ges 1 gång/dygn, bestäms 8 tim. efter given dos och bör då uppgå till 1,5-4,0 mg/L.. Doseringsanvisningarna förutsätter vuxen patient med normal njurfunktion. Kreatinin clearance (ml/min) = F x (140-ålder) x vikt/S-kreatinin; F≈1,2 för män; F≈1,0 för kvinnor.. Vid ökad risk för ESBL-bildande tarmbakterier (utlandsresa, utlandsvård, känt bärarskap): Meropenem 1g x 4 + amikacin (Biklin) 20-25 mg/kg x 1. Vid fasciit/myosit kontakta infektionsläkare för ställningstagande till ev i.v. immunoglobulin. Vid meningit alltid tilläggsbehandling med betametason (Betapred) 8 mg x 4.. Högre doser och ...
Read about Amikacin Inhaled and Ciprofloxacin DPI, Two Bayer Inhaled Antibiotics Granted US FDA QIDP Designation for serious lung infections.
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"Drug interactions between amikacin and ampicillin". Drugs.com. Archived from the original on 23 February 2018. Retrieved 22 ...
cefepime, ceftazidime, imipenem, meropenem or piperacillin-tazobactam; plus ciprofloxacin, levofloxacin, amikacin, gentamicin, ...
AMIKACIN SULPHATE 20. AMILORIDE HYDROCHLORIDE 21. AMINEPTINE 22. AMINOGLUTETHIMIDE 23. AMINOSALICYLIC ACID ...
Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...
Susceptible to amikacin, azithromycin, ciprofloxacin, clarithromycin and ethambutol. Resistant to isoniazid. Differential ...
Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...
April 2012). "Comparison of the Next-Generation Aminoglycoside Plazomicin to Gentamicin, Tobramycin and Amikacin". Expert ...
c. Third choice: gentamicin or amikacin (both aminoglycosides) +/- amoxicillin or vancomycin (all injectable). Aminoglycosides ... amikacin]) Antibiotics directed against Gram-positive bacteria need to be included in instances and institutions where ...
Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy. This ability to thrive in harsh ...
Aminoglycosides are antibiotics used for gram negative infections. Gram-negative means that the bacteria which cause the infection don't hold the color of a particular dye (Crystal Violet) when they're tested. Since they are not absorbed from the gut, they are usually taken by an injection into the vain or muscle but they can be given as a cream or ointment to prevent and treat skin infections, as eye drops for eye infections, as ear drops for ear infections and as a pill for intestinal infections but not for other internal infections. Antibiotics from this family can be used in patients who are not able to take some regular antibiotics, such as Penicillin because of allergies. The most common Aminoglycosides used as alternatives to Penicillin are Erythromycin (lit. Red fungus) and Clarithromycin (lit. Yellow fungus). They're most commonly used in the treatment of bacterial infections, such as Bronchitis. ...
... is antagonistic to the microbiologic effects of the antibiotics gentamicin and amikacin. The activity of rifampicin ...
A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ...
Aminoglycosides such as amikacin have been found to be very effective, as well. Quinolones can be an effective alternative. A ...
"In vivo bacterial regrowth-inhibition effect of cefbuperazone and amikacin in puerperal uterine cavity". Journal of ...
Minocycline is usually substituted when a sulfa cannot be given; high-dose imipenem and amikacin have also been used in severe ...
... gentamicin and amikacin. Intermittent fever Relapsing fever Undulant fever Remittent fever Neutropenic fever Ogoina D (August ...
... though the role of aminoglycosides such as streptomycin and amikacin has been eclipsed (because of their toxicity and ...
"Refractory Craniofacial Actinomycetoma Due to Streptomyces somaliensis That Required Salvage Therapy with Amikacin and Imipenem ...
"Phase I Pharmacokinetics of Liposomal Amikacin (MiKasome) in Human Subjects: Dose Dependence and Urinary Clearance". Abstr ...
Sampi K, Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic ...
... kanamycin and amikacin. Reports from 2009 stated that there was a high mortality rate among the thread-sail filefish, ...
S01AA21 Amikacin. S01AA22 Micronomicin. S01AA23 Netilmicin. S01AA24 Kanamycin. S01AA25 Azidamfenicol. S01AA26 Azithromycin. ...
... and amikacin are the drugs most often used in clinical trials of once-daily dosing regimens. Ugeskrift for Lægerer. ... amikacin), and it is more expensive; thus, its potential value is limited. Drug Intelligence & Clinical Pharmacy: Vol. 17, No. ...
Antibiotics that have been used to successfully treat C. violaceum include pefloxacin, ciprofloxacin, amikacin, and co- ...
Mednje sodijo amikacin, arbekacin, gentamicin, kanamicin, neomicin, netilmicin, paromomicin, rodostreptomicin[2], streptomicin ...
... i: Kanamicin • Streptomicin • Tobramicin • Neomicin • Paromomicin • Apramicin • Gentamicin • Netilmicin • Amikacin ... Među njima su amikacin, arbekacin, gentamicin, kanamicin, neomicin, netilmicin, paromomicin, rodostreptomicin,[2] streptomicin ...
The type strain isolates were susceptible in vitro to ciprofloxacin, amikacin, tobramycin, cefoxitin, clarithromycin, ...
S. olei is resistant to antibiotics including chloromycetin, kanamycin, polymyxin B, streptomycin, amikacin, gentamicin, ...
... amikacin, azithromycin, and levofloxacin. A 2018 Cochrane review suggested that the many antibiotic combinations being used are ...
... vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains". Annals of Clinical Microbiology and ...
The concentration of amikacin in the renal cortex becomes ten times that of amikacin in the plasma;[20] it then most likely ... Resistance to amikacin also confers resistance to kanamycin and capreomycin.[30] Resistance to amikacin and kanamycin in ... The elderly tend to have amikacin stay longer in their system; while the average clearance of amikacin in a 20-year-old is 6 L/ ... Treating overdoses of amikacin requires kidney dialysis or peritoneal dialysis, which reduce serum concentrations of amikacin, ...
... has role nephrotoxin (CHEBI:61015) amikacin (CHEBI:2637) is a α-D-glucoside (CHEBI:22390) amikacin (CHEBI ... amikacin (CHEBI:2637) is a carboxamide (CHEBI:37622) amikacin (CHEBI:2637) is conjugate base of amikacin(4+) (CHEBI:84739) ... amikacin (CHEBI:2637) has functional parent kanamycin A (CHEBI:17630) amikacin (CHEBI:2637) has role antibacterial drug (CHEBI: ... Amikacin KEGG COMPOUND O-. 3-. amino-. 3-. deoxy-. α-. D-. glucopyranosyl-. (1→4)-. O-. (6-. amino-. 6-. deoxy-. α-. D- ...
Amikacin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use amikacin injection until you finish the prescription, even if you feel better. If you stop using amikacin injection too ... Before receiving amikacin injection,. *tell your doctor and pharmacist if you are allergic to amikacin injection; other ... If you become pregnant while using amikacin injection, call your doctor immediately. Amikacin may harm the fetus. ...
Adverse effects and choice between the Injectable agents amikacin and capreomycin in Multidrug-resistant tuberculosis. ...
Amikacin sulfate is an antibiotic used for multiple drug-resistant bacterial infections. Learn about side effects, drug ... What preparations of amikacin are available?. Amikacin sulfate injection is colorless solution. It is available in 50 mg/ml and ... Amikacin is a man-made aminoglycoside antibiotic. It is similar to tobramycin and gentamicin. Amikacin binds to components of ... amikacin sulfate. *What is amikacin injection, and how does it work (mechanism of action)? ...
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... is used to treat severe or serious bacterial infections. Amikacin may also be used for purposes not listed in this ... What is amikacin?. Amikacin is an antibiotic that fights bacteria.. Amikacin is used to treat severe or serious bacterial ... What is the most important information I should know about amikacin?. Amikacin can harm your kidneys, and may also cause nerve ... Amikacin is usually given for 7 to 10 days.. Amikacin is injected into a muscle, or into a vein through an IV. You may be shown ...
AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 250 mg in 1 mL. ... AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 250 mg in 1 mL. ... Amikacin. Sulfate Injection, USP equivalent to amikacin. 1 gram/4 mL. (250 mg/mL). FOR IM OR IV USE 4 mL Vial. Each mL contains ... Amikacin. Sulfate. Injection, USP equivalent to amikacin. 500 mg/2 mL. (250 mg/mL). FOR IM OR IV USE 2 mL Single Dose Vial ...
Amikacin is used to treat severe or serious bacterial infections. Amikacin may also be used for purposes not listed in this ... What other drugs will affect amikacin?. What other drugs will affect amikacin?. Amikacin can harm your kidneys. This effect is ... What is amikacin?. What is amikacin?. Amikacin is an antibiotic that fights bacteria. ... How is amikacin given?. How is amikacin given?. Follow all directions on your prescription label. Do not use this medicine in ...
Erfa-Amikacin; VPI-Amikacin. Warning. *This drug may cause kidney, nerve, and hearing problems (like long-lasting hearing loss ... Amikacin (Systemic) - Last updated on May 8, 2021. All rights owned and reserved by Memorial Sloan Kettering Cancer Center. ... If you have an allergy to amikacin or any other part of this drug. ...
AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 500 mg in 2 mL. ... AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 1 g in 4 mL. ... Amikacin has demonstrated in vitro activity against the following bacteria. The safety and effectiveness of amikacin in ... In these patients, serum amikacin concentrations should be measured to assure accurate administration of amikacin and to avoid ...
Find patient medical information for amikacin injection on WebMD including its uses, side effects and safety, interactions, ... Amikacin SULFATE Vial Common Brand(S): Amikin Generic Name(S): amikacin View Free Coupon * Uses ... How to use Amikacin SULFATE Vial This medication is given by injection into a vein or muscle as directed by your doctor. It is ... Amikacin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/ ...
Amikacin (Oral Inhalation) - Generated on April 25, 2019. ©2019 Memorial Sloan Kettering Cancer Center. ...
Easy-to-read patient leaflet for Amikacin (Systemic). Includes indications, proper use, special instructions, precautions, and ... What do I need to tell my doctor BEFORE I take Amikacin?. *If you have an allergy to amikacin or any other part of amikacin ( ... How do I store and/or throw out Amikacin?. *If you need to store amikacin (systemic) at home, talk with your doctor, nurse, or ... How is this medicine (Amikacin) best taken?. Use amikacin (systemic) as ordered by your doctor. Read all information given to ...
Amikacin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... Amikacin has demonstrated in vitro activity against the following bacteria. The safety and effectiveness of Amikacin in ... PACKAGE LABEL - PRINCIPAL DISPLAY - Amikacin 500 mg Single Dose Vial Label. Amikacin Sulfate Injection, USP. 500 mg per 2 mL ( ... PACKAGE LABEL - PRINCIPAL DISPLAY - Amikacin 500 mg Single Dose Vial Carton Panel. NDC 63323-815-02. Amikacin Sulfate Injection ...
Posted in Health Concerns, Pharmaceuticals, Product Recalls, Recalled Drugs , Tagged amikacin recall, Amikacin Sulfate ... Tag Archives: amikacin recall. This page is having a slideshow that uses Javascript. Your browser either doesnt support ... Teva Pharmaceuticals based in North Wales, Pennsylvania, announced a voluntary recall of seven lots of Amikacin Sulfate ... Amikacin Sulfate Injection is used … Continue reading →. ...
Find patient medical information for Amikacin (PF) Injection on WebMD including its uses, side effects and safety, interactions ... How to use Amikacin (PF) Solution. This medication is given by injection into a vein or muscle as directed by your doctor. It ... Amikacin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/ ... Before using amikacin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such ...
Several forms of amikacin are used currently, including an intravenous (IV) or intramuscular (IM) injection. In September 2018 ... Amikacin also exerts excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, ... Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the ... Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] ...
... amikacin injection suppliers and exporters. These amikacin injection manufacturing companies are offering high quality products ... Amikacin Injection Amikacin injection is used to treat serious bacterial infections in many different parts of the body. This ... AMIKACIN SULFATE INJECTION USP 100MG / 2ML Amikacin injection is used to treat serious bacterial infections in many different ... Amikacin InjectionWe Rewine Pharmaceutical are a leading Manufacturer and Exporter of Amikacin vial in different strength and ...
P stands for Amikacin plus penicillin. A+P is defined as Amikacin plus penicillin very rarely. ... 2018 https://www.acronymfinder.com/Amikacin-plus-penicillin-(A%2bP).html. *Chicago style: Acronym Finder. S.v. "A+P." Retrieved ... APA style: A+P. (n.d.) Acronym Finder. (2018). Retrieved December 14 2018 from https://www.acronymfinder.com/Amikacin-plus- ... a href=https://www.acronymfinder.com/Amikacin-plus-penicillin-(A%2bP).html,A+P,/a,. ...
... sulfate is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. D-Streptamine, O-3-amino-3-deoxy-a-b- ... The 500 mg per 2 mL vial and the 1 gram per 4 mL vial, each mL contains: 250 mg Amikacin(as the sulfate), 0.66% Sodium ... Serum concentrations of amikacin should be monitored when feasible to assure adequate levels and to avoid potentially toxic ... The 100 mg per 2 mL vial, each mL contains: 50 mg Amikacin(as the sulfate), 0.13% Sodium Metabisulfite, 0.5% Sodium Citrate ...
... said on Friday that Amikacin Inhale, an integrated drug-device combination being tested in patients with a type of pneumonia, ... Amikacin Inhale is a drug-device combination product that combines a specially formulated version of the antibiotic amikacin ... Bayers Amikacin Inhale Fails to Meet Objectives in Phase 3 Trial. By Sonia Amaral Rohter. Published November 24, 2017. ... In the study, Amikacin Inhale failed to demonstrate superiority over the placebo and therefore did not meet either the primary ...
van der Auwera, P., de Moor, G., Lacroix, G. et al. In vitro activity of enoxacin compared with norfloxacin and amikacin. Eur. ... In vitro activity of enoxacin compared with norfloxacin and amikacin. *P. van der Auwera. 1. , ... 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. ...
... Sikander A. K. Lodhi,1 G. ... "Postoperative Nocardia Endophthalmitis and the Challenge of Managing with Intravitreal Amikacin," Case Reports in ...
Drug Information available for: Amikacin Amikacin sulfate Genetic and Rare Diseases Information Center resources: Bacterial ... Amikacin Penetration Into the Cerebrospinal Fluid. The safety and scientific validity of this study is the responsibility of ... Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired ... Culture proved bacterial meningitis where the prescribed therapy includes the use of systemic and intraventricular amikacin ...
Amikacin was synthesized by acylation with the l-(−)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the ... The most widely used semisynthetic aminoglycoside is amikacin, which is refractory to most aminoglycoside modifying enzymes. ... Ib and extend the useful life of amikacin. Small molecules as well as complexes ionophore-Zn+2 or Cu+2 were found to inhibit ... deoxystreptamine moiety of kanamycin A. The main amikacin resistance mechanism found in the clinics is acetylation by the ...
Injectable; Injection; Amikacin Sulfate 250 mg / ml*Injectable; Injection; Amikacin Sulfate 50 mg / ml. ...
D06AX12 - Amikacin*J01GB06 - Amikacin*S01AA21 - Amikacin. Pharmaceutical companies: manufacturers, researchers, developers, ... Injectable; Injection; Amikacin 125 mg / ml*Injectable; Injection; Amikacin 250 mg / ml*Injectable; Injection; Amikacin 50 mg ...
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  • In people with a CNS infection such as meningitis, amikacin can be given intrathecally (by direct injection into the spine) or intraventricularly (by injection into the ventricles of brain). (wikipedia.org)
  • Your doctor may not want you to receive amikacin injection. (medlineplus.gov)
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection. (medlineplus.gov)
  • Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (medlineplus.gov)
  • Amikacin injection is in a class of medications called aminoglycoside antibiotics. (medlineplus.gov)
  • Antibiotics such as amikacin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
  • Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). (medlineplus.gov)
  • You may receive amikacin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
  • If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
  • You should begin to feel better during the first few days of treatment with amikacin injection. (medlineplus.gov)
  • Use amikacin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
  • If you stop using amikacin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
  • or any of the ingredients in amikacin injection. (medlineplus.gov)
  • What is amikacin injection, and how does it work (mechanism of action)? (medicinenet.com)
  • Amikacin sulfate injection is colorless solution. (medicinenet.com)
  • Amikacin sulfate (Amikin - discontinued) is an antibiotic injection prescribed to treat bacterial meningitis, infected burns, cystic fibrosis, and severe UTI infections. (medicinenet.com)
  • Amikacin sulfate injection, USP is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. (drugs.com)
  • Teva Pharmaceuticals based in North Wales, Pennsylvania, announced a voluntary recall of seven lots of Amikacin Sulfate Injection USP, 500 mg/2mL and 1 tram/4mL vials as a result of the potential presence of glass particulate matter. (newsinferno.com)
  • Several forms of amikacin are used currently, including an intravenous (IV) or intramuscular (IM) injection. (drugbank.ca)
  • The amikacin sulfate injection is indicated in the short-term treatment of serious bacterial infections due to susceptible strains of gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, as well as Acinetobacter (Mima-Herellea) species. (drugbank.ca)
  • Amikacin Sulphate 500 MG Injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci. (tradeindia.com)
  • The 500 mg per 2 mL vial and the 1 gram per 4 mL vial, each mL contains: 250 mg Amikacin(as the sulfate), 0.66% Sodium Metabisulfite, 2.5% Sodium Citrate Dihydrate, Water for Injection qs, Air replaced with Nitrogen. (egeneralmedical.com)
  • 4 strengths of Amikacin Injection Solution are available, ranging from 50 mg/ml to 300 mg/ml. (wedgewoodpharmacy.com)
  • Pars plana vitreous tap of 0.2 ml was performed followed by injection of 1 mg/0.1 ml of vancomycin and 0.4 mg/0.1 ml of amikacin. (bmj.com)
  • Hypotheses for toxicity include dilution errors, raised post-injection intraocular pressure, concomitant use of high concentrations of subconjunctival amikacin, and variations in vitreous concentration. (bmj.com)
  • Amikacin is an antibiotic used for a number of bacterial infections . (wikipedia.org)
  • Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever . (wikipedia.org)
  • Amikacin is a man-made aminoglycoside antibiotic. (medicinenet.com)
  • Amikacin is an antibiotic that fights bacteria. (rexhealth.com)
  • Amikacin is an aminoglycoside antibiotic. (drugbank.ca)
  • Amikacin Inhale is a drug-device combination product that combines a specially formulated version of the antibiotic amikacin with an inhalation system developed by Nektar Therapeutics (NKTR) to deliver the drug to the patient's lungs. (foxbusiness.com)
  • The limited available data precludes establishing an antibiotic regimen in patients suffering from bacterial meningitis after head trauma, or spontaneous bleeding Understanding the disposition of Amikacin administered intrathecally will enable to propose rational treatment of these patients. (clinicaltrials.gov)
  • Amikacin disulfate is used as an aminoglycoside antibiotic derived from Kanamycin A, used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. (alfa.com)
  • Amikacin liposome is an antibiotic that is used to treat Mycobacterium avium complex ( MAC ) lung disease in adults who have few or no other treatment options. (rxlist.com)
  • AMIKACIN (am i KAY sin) is an aminoglycoside antibiotic. (ahealthyme.com)
  • Amikacin is an injectable antibiotic that is used to treat serious bacterial infections in dogs, cats, horses, ferrets, birds, reptiles, pocket pets/small mammals and pet fish. (lambertvetsupply.com)
  • Amikacin is a bactericidal antibiotic which means that it kills the bacteria that are sensitive to it. (lambertvetsupply.com)
  • To solve this problem, pharmacy staff studied the stability of three 5% solutions of vancomycin, amikacin, and ceftazidime prepared in aseptic conditions from parenteral antibiotic solutions. (unboundmedicine.com)
  • Fortified Antibiotic (vancomycin, Amikacin and Ceftazidime) Eye Drop Stability Assessment at -20 Degrees C]." Journal Francais D'ophtalmologie, vol. 30, no. 8, 2007, pp. 807-13. (unboundmedicine.com)
  • Doripenem sensitive combined with amikacin sensitive reduced MIC significantly in all bacterial isolates when compared to single MIC of each antibiotic. (hindawi.com)
  • MAT2501 is an oral, encochleated formulation of the broad-spectrum aminoglycoside antibiotic agent amikacin, which utilizes the Company's proprietary LNC platform to achieve oral bioavailability, limit toxicity and enable targeted delivery to sites of infection. (biospace.com)
  • Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. (lktlabs.com)
  • Aminoglycosides, including amikacin, are not indicated in uncomplicated first-time episodes of urinary tract infections unless the causative organisms are not susceptible to antibiotics which are less toxic. (drugbank.ca)
  • The range of antimicrobial movement of amikacin is the biggest of aminoglycosides, has an imperviousness to the compound that inactivates this gathering. (medicinesmexico.com)
  • At the point when the strains of the above organic entities are impervious to different aminoglycosides, including gentamicin, tobramycin and kanamycin, may at present be powerless in vitro to amikacin sulfate. (medicinesmexico.com)
  • Amikacin is impervious to debasement by most compounds inactivating influencing aminoglycosides gentamycin, kanamycin and tobramycin. (medicinesmexico.com)
  • Aminoglycosides, including amikacin sulfate infusion, are not showed for starting scenes of uncomplicated urinary tract diseases unless the causative specialists is not vulnerable to anti-microbials having less potential danger. (medicinesmexico.com)
  • Hypersensitivity to amikacin and other aminoglycosides. (mims.com)
  • AMIKACIN WOCKHARDT is indicated in the treatment of neonatal sepsis when sensitivity testing indicates that other aminoglycosides cannot be used. (healthdirect.gov.au)
  • You should not use this medicine if you are allergic to amikacin or similar antibiotics such as gentamicin, kanamycin, neomycin, paromomycin, streptomycin, or tobramycin. (rexhealth.com)
  • Amikacin was synthesized by acylation with the l -(−)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A. The main amikacin resistance mechanism found in the clinics is acetylation by the aminoglycoside 6′- N -acetyltransferase type Ib [AAC(6′)-Ib], an enzyme coded for by a gene found in integrons, transposons, plasmids, and chromosomes of Gram-negative bacteria. (mdpi.com)
  • Amikacin sulfate is an anti-infection of the group of semisynthetic aminoglycoside kanamycin subsidiary. (medicinesmexico.com)
  • Chemistry - A semi-synthetic aminoglycoside derived from kanamycin, amikacin occurs as a white, crystalline powder that is sparingly soluble in water. (elephantcare.org)
  • The most frequent AMEs genes detected were the aac(6')-Ib gene (6'N-Acetyltransferase type Ib enzyme) in 69% of strains, conferring resistance to amikacin, kanamycin, tobramycin, and nieoniycin, and the gene aac(3)-IIa (3-Acetyltransferase type 3-IIa enzyme), in 36% of strains, conferring resistance to gentamlicin. (eurekamag.com)
  • Amikacin is most often used for treating severe infections with multidrug-resistant , aerobic Gram-negative bacteria, especially Pseudomonas , Acinetobacter , Enterobacter , E. coli , Proteus , Klebsiella , and Serratia . (wikipedia.org)
  • Amikacin treats infections caused by gram-negative bacteria such as Pseudomonas species, Escherichia coli , Providencia species, Indole-positive and indole-negative Proteus species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter . (medicinenet.com)
  • The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients. (clinicaltrials.gov)
  • Amikacin is shown for the treatment of diseases brought on by powerless living beings, for example, Gram negative: amikacin is dynamic in vitro against Pseudomonas species, Escherichia coli, Proteus (indolpositivo, indolnegativo), Providencia sp, Klebsiella-Enterobacter-Serratia sp, Acinetobacter (Mima-Herellea above) freundii and Citrobacter sp. (medicinesmexico.com)
  • The in vitro studies show that amikacin sulfate, in mix with a beta-lactam, anti-infection acts synergistically against numerous gram-negative life forms that are of clinical significance, as Proteus rettgeri, Providencia stuartii, Serratia marcescens or Pseudomonas aeruginosa. (medicinesmexico.com)
  • Amikacin susceptibility against Pseudomonas aeruginosa was 91.1%, and only polymyxin B (100%) achieved higher susceptibility rates. (dovepress.com)
  • Amikacin is most often used for treating severe, hospital-acquired infections with multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. (europages.co.uk)
  • We investigated the effects of the timing of amikacin (AMK) administration on the kinetics, the efficacy against intraperitoneal infection with Pseudomonas aeruginosa, and the toxicity of AMK in mice with and without immunosuppression. (nih.gov)
  • In Pseudomonas aeruginosa strains, synergistic effect was exhibited by ertapenem plus amikacin and ertapenem plus fluoroquinolones. (uwi.edu)
  • Several strains of Pseudomonas aeruginosa, Proteus, and Serratia that are resistant to gentamicin will still be killed by amikacin. (elephantcare.org)
  • Amikacin pharmacokinetics in patients receiving high-dose cancer chemotherapy. (asm.org)
  • We retrospectively analyzed amikacin pharmacokinetics in 28 patients (mean age, 47.4 +/- 13.6 years) who received high-dose chemotherapy during a neutropenic febrile episode. (asm.org)
  • The pharmacokinetics of gentamicin, tobramycin, and amikacin in the inner ear fluids and serum of the guinea pig were studied. (springer.com)
  • Amikacin belongs to a class of drugs known as aminoglycoside antibiotics . (webmd.com)
  • The use of amikacin in the treatment of staphylococcal infections should be restricted only to second-line therapy, and should be limited to only those patients suffering from severe infections caused by susceptible strains of staphylococcus species who have failed to show sensitivity to other available antibiotics. (drugbank.ca)
  • Amikacin liposome is given in combination with other antibiotics. (rxlist.com)
  • Amikacin liposome is given only to certain adults, when other antibiotics have failed to clear their MAC infections after 6 months of treatment. (rxlist.com)
  • Amikacin portrayed comparable or better susceptibility rates to most of the tested antibiotics against E . coli , K . pneumoniae , P . aeruginosa , and A . baumannii in China. (dovepress.com)
  • Empirical treatment with antibiotics combination has been recommended in severe sepsis and septic shock to reduce mortality such as meropenem and amikacin, meropenem and levofloxacin, and carbapenem (meropenem, imipenem, and doripenem) and polymyxin [ 5 , 6 ]. (hindawi.com)
  • Pharmacology - Amikacin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibiting protein synthesis. (elephantcare.org)
  • Amikacin (aminoglycoside) antibiotics frequently used in the treatment of Gram-negative bacterial infection in neonates, but its usage restricted due to nephrotoxicity and ototoxicity as a major side effect. (alliedacademies.org)
  • Aminoglycoside antibiotics such as gentamicin and amikacin may thus be introduced as a treatment regimen for typhoid fever. (who.int)
  • This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. (koreascience.or.kr)
  • All scaffolds exhibited an initial burst of antibiotics, but groups containing chitosan reduced the burst for amikacin at 1hr by 50%, and vancomycin by 14-25% over the first 2 days. (koreascience.or.kr)
  • Amikacin is used to treat infections caused by bacteria that are resistant to gentamicin and tobramycin. (medicinenet.com)
  • The stability of amikacin to most of the bacterial enzymes that inactivate gentamicin and tobramycin makes it an agent of first choice against aminoglycoside-resistant gram-negative bacteria. (semanticscholar.org)
  • The concurrent use of amikacin with potent diuretics (ethacrynic acid, or furosemide) should be avoided since diuretics by themselves may cause ototoxicity. (nih.gov)
  • Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. (nih.gov)
  • Fifty-four patients treated with gentamicin and 52 patients treated with amikacin were evaluated for nephrotoxicity and ototoxicity in a prospective, randomized, blinded comparative trail. (nih.gov)
  • Amikacin is used as second line therapy in pulmonary tuberculosis, and ototoxicity may occur after several weeks or months of its use, as in the present case. (alliedacademies.org)
  • The Incidence of Amikacin Ototoxicity in Multidrug-Resistant Tuberculosis Patients', Iranian Journal of Pharmaceutical Research , Volume 10(4), pp. 905-911. (ac.ir)
  • Amikacin has been shown to irreversibly suppressCochlear activity.The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB) were included.All patients received fixed dose of intravenous amikacin(500 mg/day) and anti-TB medications for six months. (ac.ir)
  • However, risk factors' determination and monitoring of audiometric result variations could haveinfluenced the incidence of the amikacin ototoxicity. (ac.ir)
  • Amikacin liposome inhalation suspension was approved for the treatment of lung disease caused by a group of bacteria, Mycobacterium avium complex (MAC) in a limited population of patients with the disease who do not respond to conventional treatment (refractory disease). (drugbank.ca)
  • A pharmacodynamic threshold MIC ≤ 256 mg/L was also applied for amikacin since its inhalation formulation has demonstrated activity up to these MICs. (dovepress.com)
  • Currently, amikacin can only be delivered parenterally or through inhalation and is used to treat a variety of chronic and acute bacterial infections, including both NTM infections and various multidrug-resistant gram-negative bacterial infections. (biospace.com)
  • [10] Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
  • Amikacin is also used in certain staphylococcal infections as well. (medicinenet.com)
  • Amikacin is used to treat severe or serious bacterial infections. (rexhealth.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of the amikacin and other antibacterial drugs, amikacin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Clinical studies have shown amikacin also to be effective in serious, complicated, and recurrent urinary tract infections due to the above organisms. (drugbank.ca)
  • Amikacin may be used as initial therapy in suspected gram-negative infections and therapy may be initiated before obtaining the results of susceptibility testing. (drugbank.ca)
  • The award will support preclinical development of MAT2501, Matinas' lipid nano-crystal (LNC) oral formulation of the broad-spectrum aminoglycoside amikacin, toward an indication to treat nontuberculous mycobacterial (NTM) lung disease, including infections in patients with cystic fibrosis (CF). (biospace.com)
  • Uses/Indications - While parenteral use is only approved in dogs, amikacin is used clinically to treat serious gram negative infections in most species. (elephantcare.org)
  • Amikacin in the treatment of hospital infections of the urinary tract caused by gram-negative bacilli resistant to gentamicin. (eurekamag.com)
  • AMIKACIN WOCKHARDT is indicated in the short-term treatment of serious infections caused by susceptible strains of Gram-negative bacteria , (see Microbiology). (healthdirect.gov.au)
  • Clinical studies have shown amikacin to be effective in treating bacteraemia, septicaemia including neonatal sepsis and serious infections of the respiratory tract, bones and joints, central nervous system, skin and skin structures (including those resulting from burns ), intra-abdominal organs, post- operative infections and complicated and recurrent urinary tract infections , when caused by susceptible organisms. (healthdirect.gov.au)
  • We report the in vitro activity of amikacin and comparators against Gram-negative bacteria collected from blood and respiratory specimens in China during a 1-year period between December 2015 and December 2016. (dovepress.com)
  • The purpose of this study was to determine the synergistic activity of amikacin/ertapenem, fluoroquinolones (ciprofloxacin and levofloxacin)/ertapenem and amikacin/fluoroquinolones combinations against resistant nosocomial pathogens. (uwi.edu)
  • Kawaguchi H. Discovery, chemistry, and activity of amikacin. (lktlabs.com)
  • What is the dosage for amikacin? (medicinenet.com)
  • One of the dosage forms available for Amikacin is Topical Spray. (wedgewoodpharmacy.com)
  • Amikacin is also available in these dosage forms. (wedgewoodpharmacy.com)
  • Administration of dosage regimens based on predicted pharmacokinetic parameters yielded subtherapeutic amikacin concentrations in serum in our patients. (asm.org)
  • One of the dosage forms available for Amikacin/Silver Sulfadiazine is Otic Ointment. (wedgewoodpetrx.com)
  • The dosage form available for Amikacin/DMSO/Ketoconazole/Triamcinolone is Polox-A-Gel Otic. (wedgewoodpetrx.com)
  • Amikacin/DMSO/Ketoconazole/Triamcinolone is also available in this dosage form. (wedgewoodpetrx.com)
  • Adverse effects and choice between the Injectable agents amikacin and capreomycin in Multidrug-resistant tuberculosis. (springer.com)
  • The new GenoType Mycobacterium tuberculosis drug resistance second line (MTBDR sl ) assay (Hain Lifescience, Nehren, Germany) was tested on 106 clinical isolates and directly on 64 sputum specimens for the ability to detect resistance to fluoroquinolones, injectable drugs (amikacin or capreomycin), and ethambutol in Mycobacterium tuberculosis strains. (asm.org)
  • Cefepime monotherapy was compared with cefepime-plus-amikacin dual therapy for treatment of febrile neutropenic patients. (ebscohost.com)
  • In order to determine the optimal antipseudomonal therapy in patients with cystic fibrosis aztreonam plus amikacin was compared to ceftazidime plus amikacin, and these two-week hospital regimens were followed by oral ciprofloxacin given for four weeks. (nih.gov)
  • Patients were randomized to receive cefepime (CFP) or ceftriaxone plus amikacin (CFT+AK). (thescipub.com)
  • The in vitro activity of enoxacin was tested against 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. (springer.com)
  • In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans. (nih.gov)
  • MICs of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin were determined for 14 primary clinical isolates and three reference isolates of Mycobacterium ulcerans by modifying a standard agar dilution method for testing Mycobacterium tuberculosis sensitivity. (nih.gov)
  • For Escherichia coli , including extended-spectrum beta-lactamase (ESBL)-producing isolates (45.7% of population), amikacin demonstrated excellent activity (93.0%-94.7% susceptible) similar to tigecycline, piperacillin/tazobactam, and the carbapenems. (dovepress.com)
  • Finally, MDR was very common (84.0%) among Acinetobacter baumannii , with amikacin susceptibility at 30.5% for all isolates and 17.3% for MDR isolates. (dovepress.com)
  • The rationale for amikacin use relates to the relatively high incidence of Gram negative isolates in endophthalmitis (6.4-26.2%) 3- 5 and the broad spectrum of action with low resistance offered by this agent. (bmj.com)
  • Results: Two hundred and thirty-four Enterobacteriaceae isolates were found to be more susceptible to amikacin and isepamicin than to gentamicin. (thefreelibrary.com)
  • The results revealed that amikacin and isepamicin exerted excellent antibacterial activity (94% vs. 93.6%) against all tested isolates. (thefreelibrary.com)
  • sup][7],[8] It is effective against Gram-negative bacilli, including drug-resistance bacterial isolates, with similar susceptibility to amikacin. (thefreelibrary.com)
  • This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained from blood of patients clinically suspected of enteric fever who attended the Calcutta School of Tropical Medicine from 1991 to 2003. (who.int)
  • The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 μg/mL and 0.005-3.5 μg/mL respectively. (who.int)
  • A total of 63 strains harboring fluoroquinolone, amikacin/capreomycin, or ethambutol resistance and 43 fully susceptible strains were comparatively analyzed with the new MTBDR sl assay, by DNA sequencing, and by conventional drug susceptibility testing in liquid and solid media. (asm.org)
  • Comparison of susceptibility of Enterobacteriaceae causing community-onset urinary tract infection to isepamicin and amikacin by the disc diffusion method. (thefreelibrary.com)
  • The aim of this study was to evaluate the susceptibility of clinically isolated Enterobacteriaceae to isepamicin and amikacin using disc diffusion method. (thefreelibrary.com)
  • The susceptibility of tested isolated to isepamicin measured by disc diffusion method is comparable to that of amikacin. (thefreelibrary.com)
  • To investigate the susceptibility to gentamicin, amikacin and ciprofloxacin and the presence of some aminogloycoside modifying enzyme (AMEs) among nosocomial strains of K pneumoniae subspecie pneumoniae producing ESBL. (eurekamag.com)
  • Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
  • Amikacin carries a boxed warning of loss of hearing and kidney dysfunction for individuals treated with high doses or for longer periods. (medicinenet.com)
  • The risk of these problems may be higher if you already have kidney or hearing problems, if you get high doses of amikacin (systemic), or if you get amikacin (systemic) for a long time. (drugs.com)
  • Clinical Relevance- Co-elution of amikacin and cefazolin from PMMA at the selected doses cannot be recommended for sustained treatment of infection. (wiley.com)
  • Amikacin alone did not show any neuromuscular blocking action in normal man in therapeutic doses (100-200 mg). (semanticscholar.org)
  • The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to the lungs. (youscribe.com)
  • Serum concentrations of amikacin should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels and prolonged peak concentrations above 35 micrograms per mL. (nih.gov)
  • According to our definition of nephrotoxicity (an increase in serum creatinine levels to at least 50 percent and 0.5 mg/dl above the baseline value), nephrotoxicity occurred in eight (15 percent) of the patients who were treated with gentamicin and none of the patients who were treated with amikacin (p = 0.006). (nih.gov)
  • Amikacin pharmacokinetic parameters were calculated from two or more concentrations in serum around a single dose by the method of Sawchuck and Zaske (J. Pharmacokinet. (asm.org)
  • In healthy, ventilated piglets receiving either intravenous or nebulized amikacin, pulmonary concentrations were found to be about 10 times higher in the nebulization group than in the intravenous group, 10 whereas peak serum concentrations were 4 times lower. (asahq.org)
  • The same day, urine and serum amikacin concentrations were determined at different time points. (youscribe.com)
  • Results Median (range) ELF amikacin and maximum serum amikacin concentrations were 976.1 (135.7-16127.6) and 0.9 (0.62-1.73) μg/mL, respectively. (youscribe.com)
  • Conclusions PDDS delivery of aerosolized amikacin achieved very high aminoglycoside concentrations in ELF from radiography-controlled infection-involved zones, while maintaining safe serum amikacin concentrations. (youscribe.com)
  • The ELF concentrations always exceeded the amikacin minimum inhibitory concentrations for Gram-negative microorganisms usually responsible for these pneumonias. (youscribe.com)
  • Which drugs or supplements interact with amikacin? (medicinenet.com)
  • Do not use amikacin (systemic) if you are taking or have recently taken any drugs that can cause nerve, kidney, or hearing problems. (drugs.com)
  • You must check to make sure that it is safe for you to take amikacin (systemic) with all of your drugs and health problems. (drugs.com)
  • If concomitant treatment with a penicillin type drug is indicated, then the drugs should be administered separately because in-vitro mixing of the two drugs causes inactivation of amikacin. (healthdirect.gov.au)
  • [9] The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus [9] and Nocardia . (wikipedia.org)
  • Amikacin also exerts excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium (M. avium-intracellulare, M. chelonae, and M. fortuitum) 4 . (drugbank.ca)
  • Staphylococcus aureus, including methicillin-resistant strains, is the principal Gram-positive organism sensitive to amikacin. (drugbank.ca)
  • The trial was studying Amikacin Inhale in intubated and mechanically ventilated patients with Gram-negative pneumonia. (foxbusiness.com)
  • Gram-positive: Amikacin is dynamic in vitro against Staphylococcus species makers and non-makers of penicillinase, including methicillin-safe strains. (medicinesmexico.com)
  • 1 Amikacin, an aminoglycoside, is in widespread use in the United Kingdom for the treatment of Gram negative organisms in endophthalmitis. (bmj.com)
  • 1.3 grams of amikacin sulfate is equivalent to 1 gram of amikacin. (elephantcare.org)
  • Methods Nebulized amikacin (400 mg bid) was delivered to the lungs of 28 mechanically ventilated patients with Gram-negative VAP for 7-14 days, adjunctive to intravenous therapy. (youscribe.com)
  • The purpose of present study was to examine phospholipiduria in humans and to compare the effect of amikacin and netilmicin in this respect. (springer.com)
  • The effect of amikacin on the neuromuscular junction was studied in man during anesthesia and surgery. (semanticscholar.org)
  • It is not known whether amikacin passes into breast milk or if it could harm a nursing baby. (rexhealth.com)
  • It is not known whether amikacin as an inhaled medicine will harm an unborn baby. (everydayhealth.com)
  • Ceftazidime and amikacin were diluted in 0.9% sodium chloride and vancomycin in 5% dextrose. (unboundmedicine.com)
  • maximum daily dose 12g) in combination with amikacin (36mg/kg/day i.v. (nih.gov)
  • In patients with cystic fibrosis, aztreonam or ceftazidime in combination with amikacin represents an effective and safe systemic anti-pseudomonal therapy. (nih.gov)
  • Hearing loss can happen even after amikacin (systemic) is stopped. (drugs.com)
  • Very bad muscle problems and very bad breathing problems have happened with amikacin (systemic). (drugs.com)
  • Tell all of your health care providers that you take amikacin (systemic). (drugs.com)
  • If you are 65 or older, use amikacin (systemic) with care. (drugs.com)
  • If you are pregnant or you get pregnant while taking amikacin (systemic), call your doctor right away. (drugs.com)
  • Use amikacin (systemic) as ordered by your doctor. (drugs.com)
  • Culture proved bacterial meningitis where the prescribed therapy includes the use of systemic and intraventricular amikacin therapy. (clinicaltrials.gov)
  • What is amikacin liposome (Arikayce)? (rxlist.com)
  • What is the most important information I should know about amikacin liposome (Arikayce)? (rxlist.com)
  • What should I discuss with my healthcare provider before using amikacin liposome (Arikayce)? (rxlist.com)
  • How should I use amikacin liposome (Arikayce)? (rxlist.com)
  • Can I take Arikayce (Amikacin Liposome) if I'm pregnant or breastfeeding? (everydayhealth.com)
  • Use Arikayce (Amikacin Liposome) exactly as directed on the label, or as prescribed by your doctor. (everydayhealth.com)
  • Here, we investigated the efficacy of exogenously administered synthetic KAMP-10 against amikacin-resistant P. aeruginosa keratitis in a mouse model. (arvojournals.org)
  • Corneas of anesthetized C57BL/6 mice were scratched and allowed to heal for 4 h before inoculation of 10 4 CFU (in 5 μl saline) amikacin-resistant P. aeruginosa clinical isolate. (arvojournals.org)
  • CONTRAINDICATIONS: The historical backdrop of extreme touchiness to amikacin sulfate is a contraindication to its utilization. (medicinesmexico.com)
  • Store Amikacin at room temperature between 20 C to 25 C (68 F to 77 F). (medicinenet.com)
  • Store amikacin liposome vials in the refrigerator and use them before the expiration date. (rxlist.com)
  • You may also store amikacin liposome at room temperature for up to 4 weeks. (rxlist.com)
  • Sikander A. K. Lodhi, G. Ashok Kumar Reddy, and C. Aruna Sunder, "Postoperative Nocardia Endophthalmitis and the Challenge of Managing with Intravitreal Amikacin," Case Reports in Ophthalmological Medicine , vol. 2016, Article ID 2365945, 6 pages, 2016. (hindawi.com)
  • We report a case of macular toxicity following the use of intravitreal amikacin for postoperative endophthalmitis, outline mechanisms of retinal toxicity, and offer alternatives to amikacin. (bmj.com)
  • Our case and others reported in the literature 6- 8 serve to notify clinicians of the serious retinal toxicity occurring with amikacin use, which is possibly a class related phenomenon. (bmj.com)
  • During the histopathological observation, amikacin control rats showed the renal toxicity via injury in the tubular epithelial and expansion of renal necrosis. (alliedacademies.org)
  • The piceatannol group rats confirmed the protective effect on the renal toxicity via improvement the renal damage induced by amikacin. (alliedacademies.org)
  • Amikacin causes little toxicity in carefully selected and closely monitored patients with non-tuberculous mycobacterial (NTM) disease but is less effective than previously thought, according to a case series published by Brisbane respiratory physicians. (thelimbic.com)
  • A pregnant woman taking amikacin with another aminoglycoside has a possibility of causing congenital deafness in her child. (wikipedia.org)
  • Is amikacin safe to take if I'm pregnant or breastfeeding? (medicinenet.com)
  • Do not use amikacin if you are pregnant. (rexhealth.com)
  • If you use amikacin liposome while you are pregnant, your baby could be born deaf. (rxlist.com)
  • I consulted a gynaecologist, as I am pregnant, and she gave me Monocef tablets and three Amikacin injections for three days. (ndtv.com)
  • Clinical studies have demonstrated that amikacin sulfate is successful in bacterial sepsis, including neonatal sepsis. (medicinesmexico.com)
  • Call your doctor for instructions if you miss a dose of amikacin. (rexhealth.com)
  • Long-lasting potentiation of a single-dose of rocuronium by amikacin: case report. (semanticscholar.org)
  • Long-lasting (4 hours) potentiation of single intubating dose of rocuronium by a single bolus of amikacin given 55 minutes later in a woman having no precipitating factor is reported. (semanticscholar.org)
  • Amikacin group demonstrated the low level of Glutathione Peroxidase (GPx) and the treatment with piceatannol significantly increase the level of GPx at dose dependent manner. (alliedacademies.org)
  • The level of the insulin like growth factor-1 was higher in the Amikacin control group rats, which was significantly reduced by the piceatannol at the dose-dependent manner, but the level of insulin like growth factor-1 was not reached near the normal control. (alliedacademies.org)
  • Amikacin will not treat a viral infection such as the flu or a common cold. (rexhealth.com)
  • On treatment day 3, 30 minutes after completing aerosol delivery, all the patients underwent bronchoalveolar lavage in the infection-involved area and the ELF amikacin concentration was determined. (youscribe.com)
  • In clinical studies have demonstrated that, amikacin sulfate, is likewise viable in troublesome and intermittent urinary tract contaminations created by these life forms. (medicinesmexico.com)
  • The clinical impact of amikacin delivery with this system remains to be determined. (youscribe.com)
  • OBJECTIVE : To determine the effects of regional or general anaesthesia on the clinical and synovial pharmacokinetic parameters of amikacin administered by IV-RLP to horses. (up.ac.za)
  • Objective- To compare the in vitro elution characteristics of amikacin and cefazolin from polymethylmethacrylate (PMMA) alone and in combination. (wiley.com)
  • In vitro elution of amikacin and vancomycin from impregnated plaster of Paris beads", Vet. (koreascience.or.kr)
  • Synovial fluid amikacin concentrations were measured over 24 h and regional pharmacokinetic parameters calculated. (up.ac.za)
  • RESULTS : Amikacin concentrations and regional pharmacokinetic parameters did not differ significantly among treatments. (up.ac.za)
  • CONCLUSIONS : Perineural regional anaesthesia before IV-RLP was most effective in providing comfort to standing, sedated horses without significantly affecting the regional pharmacokinetic parameters of amikacin. (up.ac.za)
  • Bayer AG (BAYN.XE) said on Friday that Amikacin Inhale, an integrated drug-device combination being tested in patients with a type of pneumonia, failed to meet the primary objective in a phase 3 trial. (foxbusiness.com)
  • Since amikacin sulfate is show in high focuses in the renal framework, patients ought to be decently hydrated to minimize substance aggravation of the renal tubule. (medicinesmexico.com)
  • A multicenter open randomized trial was conducted to compare cefepime monotherapy with cefepime/amikacin combination (dual) therapy in treating febrile neutropenic patients with hematologic disorders. (ebscohost.com)
  • The incidence of hearing loss was remarkable in MDR-TB patients treating with amikacin. (ac.ir)
  • Patients will be treated three consecutive days with inhaled amikacin or placebo. (ichgcp.net)
  • Amikacin may also be used for purposes not listed in this medication guide. (rexhealth.com)
  • Sixty five percent of strains were resistant to gentamicin, 47% were resistant to amikacin, and 29% were resistant to ciprofloxacin. (eurekamag.com)
  • Amikacin concentrations were determined by fluorescence polarization immunoassay and cefazolin concentrations by high-performance liquid chromatography. (wiley.com)
  • The pH of amikacin (6.51), ceftazidime (6.47), and vancomycin (3.77) remained stable during the 75-day period. (unboundmedicine.com)
  • A 44-year-old male patient in the 4th month of therapy for pulmonary tuberculosis with a second line regimen with levofloxacin, ethambutol and amikacin, presents at the ENT department with bilateral progressive hearing loss. (alliedacademies.org)
  • Amikacin may be administered once or twice a day and is usually given by the intravenous or intramuscular route, though it can be given via nebulization. (wikipedia.org)
  • Amikacin liposome can cause a serious allergic reaction that may lead to death. (everydayhealth.com)
  • Amikacin liposome can cause a life-threatening allergic reaction. (johnstonhealth.org)