Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Aminoglycosides: Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Capreomycin: Cyclic peptide antibiotic similar to VIOMYCIN. It is produced by Streptomyces capreolus.Ceftazidime: Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Sisomicin: Antibiotic produced by Micromonospora inyoensis. It is closely related to gentamicin C1A, one of the components of the gentamicin complex (GENTAMICINS).Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Dibekacin: Analog of KANAMYCIN with antitubercular as well as broad-spectrum antimicrobial properties.Labyrinthine Fluids: Fluids found within the osseous labyrinth (PERILYMPH) and the membranous labyrinth (ENDOLYMPH) of the inner ear. (From Gray's Anatomy, 30th American ed, p1328, 1332)Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.Kanamycin Kinase: A class of enzymes that inactivate aminocyclitol-aminoglycoside antibiotics (AMINOGLYCOSIDES) by regiospecific PHOSPHORYLATION of the 3' and/or 5' hydroxyl.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Ticarcillin: An antibiotic derived from penicillin similar to CARBENICILLIN in action.Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Perilymph: The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)Cephalothin: A cephalosporin antibiotic.Pseudomonas Infections: Infections with bacteria of the genus PSEUDOMONAS.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Aztreonam: A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)Serratia: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the natural environment (soil, water, and plant surfaces) or as an opportunistic human pathogen.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Metal-on-Metal Joint Prostheses: Types of prosthetic joints in which both wear surfaces of the joint coupling are metallic.Hip Prosthesis: Replacement for a hip joint.Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Arthroplasty, Replacement, Hip: Replacement of the hip joint.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Price ListsDrug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Drug Packaging: Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.Pharmacies: Facilities for the preparation and dispensing of drugs.Injections: Introduction of substances into the body using a needle and syringe.Pneumonia, Ventilator-Associated: Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).Pneumonia: Infection of the lung often accompanied by inflammation.Ventilators, Mechanical: Mechanical devices used to produce or assist pulmonary ventilation.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.Proteus: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the intestines of humans and a wide variety of animals, as well as in manure, soil, and polluted waters. Its species are pathogenic, causing urinary tract infections and are also considered secondary invaders, causing septic lesions at other sites of the body.Mexican Americans: Persons living in the United States of Mexican descent.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Surgery, Veterinary: A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)Polymethyl Methacrylate: Polymerized methyl methacrylate monomers which are used as sheets, moulding, extrusion powders, surface coating resins, emulsion polymers, fibers, inks, and films (From International Labor Organization, 1983). This material is also used in tooth implants, bone cements, and hard corneal contact lenses.Fluorescence Polarization Immunoassay: Fluoroimmunoassay where detection of the hapten-antibody reaction is based on measurement of the increased polarization of fluorescence-labeled hapten when it is combined with antibody. The assay is very useful for the measurement of small haptenic antigens such as drugs at low concentrations.
Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/633)Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin. (+info)
UK-18892, a new aminoglycoside: an in vitro study. (2/633)UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differences were relatively minor. UK-18892 was about twice as active as amikacin against gentamicin-susceptible strains of Pseudomonas aeruginosa. Both amikacin and UK-18892 were equally active against gentamicin-resistant strains of P. aeruginosa. There were no appreciable differences in the activity of UK-18892 and amikacin against Enterobacteriaceae and Staphylococcus aureus. Cross-resistance between these two antimicrobials was also apparent. (+info)
Bacteriologic cure of experimental Pseudomonas keratitis. (3/633)Two long-term therapy trials with high concentrations of antibiotic were carried out to determine the duration of therapy required to achieve bacteriologic cure of experimental Pseudomonas keratitis in guinea pigs. In the first study, corneas still contained Pseudomonas after 4 days of continual topical therapy with either tobramycin 400 mg/ml, amikacin 250 mg/ml, ticarcillin 400 mg/ml, or carbenicillin 400 mg/ml. In an 11-day trial of topical therapy with tobramycin 20 mg/ml, 34 of 36 corneas grew no Pseudomonas after 6 or more days of therapy. The bacteriologic response to therapy in this model occurred in two phases. About 99.9% or more of the organisms in the cornea were killed in the first 24 hr of therapy. The numbers of bacteria remaining in the cornea declined gradually over the next several days until the corneas were sterile. Optimal antibiotic therapy may include two stages: initial intensive therapy with high concentrations of antibiotic applied frequently to achieve a large rapid decrease in numbers of organisms in the cornea, followed by prolonged, less intensive therapy to eradicate organisms and prevent relapse. (+info)
Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (4/633)Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin. (+info)
Killing kinetics of intracellular Afipia felis treated with amikacin. (5/633)Afipia felis is a facultative intracellular bacterium which multiplies in macrophages following inhibition of phagosome-lysosome (P-L) fusion. When A. felis-infected cells are incubated for 72 h with various antibiotics, only aminoglycosides are found to be bactericidal. We therefore studied the killing of intracellular A. felis by amikacin, and its relationship with the restoration of P-L fusion. Amikacin reduced the number of A. felis from 8.5 x 10(5) to 3.5 x 102 cfu/mL within 94 h. P-L fusion was restored after 30-40 h of incubation with amikacin. Both mechanisms may participate in the intracellular killing of bacteria. (+info)
Effects of isolation housing and timing of drug administration on amikacin kinetics in mice. (6/633)AIM: To study the influences of social condition and drug administration time on amikacin metabolism in mice. METHODS: Forty Male ICR mice were randomly assigned into 4 groups according to 1) housing condition: individual housing (I, one mouse in a cage) or aggregated housing (A, 10 mice in a cage) and 2) drug administration time: at midday (D) or at midnight (N), i.e. I-D, I-N, A-D, and A-N groups. Amikacin was injected s.c. 15 mg.kg-1 after 4 wk of raising at D or N. Blood samples were taken at 5, 10, 15, 20, 30, and 60 min after medication in each mouse. Plasma amikacin was measured by enzyme immunoassay. The concentration-time data were fitted with one-compartment open model in each mouse and data were analyzed with group t test. RESULTS: The clearance (Cl) of amikacin was larger and the half-life (T1/2) was shorter in A-N group than in A-D or I-N groups respectively. AUC(0-1) in A-N group was less than in I-N group. No differences of kinetic parameters between 2 isolated housing (I-D and I-N) groups were found. CONCLUSION: Aggregated housing and midnight drug administration increased the disposition of amikacin. (+info)
Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. (7/633)Netilmicin (Sch 20569) is a new broad-spectrum semisynthetic aminoglycoside derived from sisomicin. Netilmicin was compared to gentamicin, tobramycin, and amikacin in a variety of in vitro test systems as well as in mouse protection tests. Netilmicin was found to be similar in activity to gentamicin against aminoglycoside-susceptible strains in both in vitro and in vivo tests. Netilmicin was also active against many aminoglycoside-resistant strains of gram-negative bacteria, particularly those known to possess adenylating enzymes (ANT 2') or those with a similar resistance pattern. Netilmicin was found to be markedly less toxic than gentamicin in chronic studies in cats, although gentamicin appeared less toxic in acute toxicity tests in mice. The concentrations of netilmicin and gentamicin in serum were compared in dogs after intramuscular dosing, and the pharmacokinetics including peak concentrations in serum were found to be similar. (+info)
Randomized prospective study comparing cost-effectiveness of teicoplanin and vancomycin as second-line empiric therapy for infection in neutropenic patients. (8/633)BACKGROUND AND OBJECTIVE: The current health-care philosophy dictates that new therapies should always be evaluated for their economic impact. Along with acquisition cost, the cost of delivery, monitoring, adverse effects and treatment failure must also be considered when determining the total cost of therapy. These auxiliary costs can be significant and greatly alter the overall cost of a drug treatment. We conducted a prospective randomized study to evaluate the efficacy, safety and cost of vancomycin and teicoplanin therapy in patients with neutropenia, after the failure of empirical treatment with a combination of piperacillin/tazobactam and amikacin. DESIGN AND METHODS: Seventy-six febrile episodes from 66 patients with hematologic malignancies under treatment, neutropenia (neutrophils <500/mm3) and fever (38 degrees C twice or 38.5 degrees C once) resistant to the combination piperacillin/tazobactam and amikacin were included in the study. RESULTS: Primary success of second-line therapy was obtained in 35 cases (46%) with no significant difference between vancomycin (17/38) and teicoplanin arms (18/38). No difference in renal or hepatic toxicity related to the antibiotic therapy was observed. The average cost per patient according to glycopeptide used was $450+/-180 for the teicoplanin group and $473+/-347 for the vancomycin group. Interestingly, in the teicoplanin arm, drug acquisition accounted for 97% of the total cost, while in the vancomycin arm administration and monitoring play an important role in overall costs. INTERPRETATION AND CONCLUSIONS: In conclusion, our pharmacoeconomic analysis demonstrates that teicoplanin and vancomycin can be administered in neutropenic hematologic patients with similar efficacy and direct costs. (+info)
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Background: Data on aminoglycoside (AG) pharmacokinetics (PK) in intermittent hemodialysis (iHD) is outdated; current practice employs more efficient iHD modalities. Once-daily AG are used to optimize treatment of resistant organisms including non-tuberculous mycobacterium (NTM). Currently recommended amikacin dosing (3-5 mg/kg post-iHD) is unlikely to obtain IDSA-recommended target Cmax for NTM (20-30mg/L). Recently, experts have suggested gentamicin dosed pre-iHD can attain maximal peak to optimize PK/PD goals; using iHD to decrease overall exposure to avoid toxicity. No PK data has described pre-iHD dosing strategy for high-dose amikacin, so it remains uncommonly practiced. Methods: We describe a high-dose strategy of IV amikacin and PK monitoring (efficacy and toxicity) in 2 cases of peritoneal dialysis peritonitis caused by NTM. Amikacin was dosed at 7mg/kg on iHD days, given 4 hours pre-iHD to allow distribution. Amikacin levels were drawn: prior to iHD (peak); 4 hours post-iHD (trough); ...
The purpose of this study was to define the potency of amikacin and comparator agents against a collection of blood and respiratory nosocomial isolates implicated in ICU based pulmonary infections gathered from US hospitals. Minimum inhibitory concentrations of amikacin, aztreonam, cefepime, ceftazidime, ceftolozane/tazobactam, ceftriaxone, ciprofloxacin, imipenem, meropenem, piperacillin/tazobactam and tobramycin were tested against 2460 Gram-negative isolates. Amikacin had 96 % susceptibility against the combined E. coli and K. pneumoniae isolates and 95 % susceptibility against P. aeruginosa. Ninety-six percent of all of isolates tested were susceptible (i.e., MICs ≤16 mg/L) to amikacin by current laboratory standards which demonstrates a high level of activity to combat infections caused by these organisms including ESBL, MDR, β-lactam and fluoroquinolone resistant strains. Moreover, 99 % of all organisms had amikacin MICs ≤64 mg/L. Overall, these data highlight the continued potency of
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Disclosed herein are methods of treating pulmonary disorders comprising administering to the patient an effective dose of a nebulized liposomal amikacin formulation for at least one treatment cycle, wherein: the treatment cycle comprises an administration period of 15 to 75 days, followed by an off period of 15 to 75 days; and the effective dose comprises 100 to 2500 mg of amikacin daily during the administration period.
Hypotheses for toxicity include dilution errors, raised post-injection intraocular pressure, concomitant use of high concentrations of subconjunctival amikacin, and variations in vitreous concentration. Local variation in concentration may play a part if the agent is directly injected into the posterior vitreous space instead of the gel itself. Another possibility for macular predilection is that this is the dependent part in the supine patient during pars plana injection.. Large studies offer alternatives to aminoglycosides on the basis of culture sensitivities.3-5, 9 Suggestions include ceftazidime, cefotaxime, and ciprofloxacin. Sensitivities of Gram negative organisms to ceftazidime range from 61% to 100% according to published studies.3-5, 9 It appears that in most studies 2 mg (0.1 ml of 20 mg/ml solution) of ceftazidime has in vitro effectiveness equipotent to or greater than 0.4 mg amikacin.3-5, 9 Primate studies have shown that intravitreal ceftazidime is non-toxic at doses of 2.25 ...
Amikacin Inj (Amikacin) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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Amikacin sulfate, a active ingredient of samu AMIKACIN injection, is a semi-synthetic aminoglycosides antibiotics derived from Kanamycin. Amikacin, like other aminoglycoside antibiotics, is a bactericidal agent that exerts its action at the level of bacterial ribosome. Amikacin has been shown to be effective against Gram-positive and Gram-negative bacteria, and many aminoglycoside-resistant strains due to its ability to resist degradation by aminoglycoside inactivating enzymes known to affect Gentamicin, Tobramycin and Kanamycin. Amikacin is a broad spectrum bactericidal antibiotic agent well absorbed following intravenous, subcutaneous or intramuscular injection and rapidly transmitted to skin and soft tissue, so it maintains a high therapeutic blood level. Amikacin has few side effects such as nephrotoxicity and ototoxicity ...
TY - JOUR. T1 - Clinical efficacy and safety of multidrug therapy including thrice weekly intravenous amikacin administration for Mycobacterium abscessus pulmonary disease in outpatient settings. T2 - A case series. AU - Namkoong, Ho. AU - Morimoto, Kozo. AU - Nishimura, Tomoyasu. AU - Tanaka, Hiromu. AU - Sugiura, Hiroaki. AU - Yamada, Yoshitake. AU - Kurosaki, Atsuko. AU - Asakura, Takanori. AU - Suzuki, Shoji. AU - Fujiwara, Hiroshi. AU - Yagi, Kazuma. AU - Ishii, Makoto. AU - Tasaka, Sadatomo. AU - Betsuyaku, Tomoko. AU - Hoshino, Yoshihiko. AU - Kurashima, Atsuyuki. AU - Hasegawa, Naoki. PY - 2016/8/9. Y1 - 2016/8/9. N2 - Background: Mycobacterium abscessus (M. abscessus) pulmonary disease is a refractory chronic infectious disease. Options for treating M. abscessus pulmonary disease are limited, especially in outpatient settings. Among parenteral antibiotics against M. abscessus, intravenous amikacin (AMK) is expected to be an effective outpatient antimicrobial therapy. This study ...
Amikacin (a-mi-KAY-sin) Treats infections. Belongs to a class of drugs called aminoglycoside antibiotics. Brand Name(s): amikacin sulfate NovaPlus
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia : Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to the lungs.
Amikacin is shown for the treatment of diseases brought on by powerless living beings, for example, Gram negative: amikacin is dynamic in vitro against Pseudomonas species, Escherichia coli, Proteus (indolpositivo, indolnegativo)
Amikacin Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin preparation information is provided by Wedgewood Pharmacy.
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Pseudomonas aeruginosa is one of the major causative microorganisms of ventilator-associated pneumonia often resistant to antibiotics. In experimental models, nebulization of antibiotics delivers high lung tissue concentrations of antibiotics in infected lungs and increases lung bacterial killing. The aim of the study is to assess the efficiency of nebulized ceftazidime and amikacin in the treatment of pneumonia caused by Pseudomonas aeruginosa in ventilated patients ...
Lysosomal phospholipidosis of proximal tubular cells is an early index of aminoglycoside-induced nephrotoxicity and has been documented both biochemically and morphometrically in animals and humans...
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Amikacin is an antibiotic used to treat a wide variety of bacterial infections. It it often employed to treat severe infections resistant to other antibioti
Sample Type: Serum Test name: Amikacin Condition / Indication: Requesters have found these assays to be of value in all patients treated for ,48 hours Advance Warning: Not usually required during our core working hours (Mon - Fri 09:00 - 17:15) or Sat 09:00-12:00 for this assay. Please contact the laboratory to discuss the possibility of this assay being performed on Sundays and Bank Holidays. Sample Required: Approx. 1-2mLl of separated serum (the minimum acceptable is 100µL). Samples may be sent by post. Transport time must be ,7 days. Samples should be kept at 4°c if there is a delay in sending. Please contact laboratory if in doubt as sample integrity may be affected. Samples must be sealed and packed to conform to current regulations. Leaking samples may not be processed. Timing of Samples: We recommend a pre dose sample and a post dose sample taken 1h after end of IV/IM admin. Test Information Required: • Patient name, sex and ...
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To the editor: Amikacin, a semisynthetic derivative of kanamycin A, was approved for unrestricted clinical use in 1976 and is considered the antibiotic of choice for use against infections with gentamicin-resistant, gram-negative bacilli (1, 2). In a recent issue, Betts and colleagues (3) have reported data on the use of amikacin as the primary empiric aminoglycoside in a large university hospital. The authors have concluded that "because it is not possible to identify patients infected with gentamicin-resistant organisms until 48 hours after therapy is initiated, it is rational to use an antibiotic agent that is likely to be effective against ...
File Title: Delivery of Aerosolized Liposomal Amikacin as a Novel Approach for the Treatment of Nontuberculous Mycobacteria in an Experimental Model of Pulmonary Infection ...
DESCRIPTION WARNINGS Patients treated with parenteral aminoglycosides should be under close clinical observation because of the potential ototoxicity and nephrotoxicity associated with their use. Safety for treatment perio...
This medication is used to prevent or treat a wide variety of bacterial infections. This medicine is given by an injection through a vein or a muscle as directed by the doctor. Nausea, vomiting, stomach upset, or loss of appetite may occur. as side effects. Older adults may be more sensitive to the effects of this drug, especially kidney damage. This medication may interract with amphotericin B, cidofovir, cisplatin, polymyxin B, tobramycin. Take the medicine as prescribed by the doctor and incase of an overdose, seek medical care.
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This medicine is infused into a vein or injected into a muscle. It is usually given by a health care professional in a hospital or clinic setting.. If you get this medicine at home, you will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.. It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
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Product Number , 33369880. CAS Number , 37517-28-5. EC , 253-538-5. Molecular Formula , C22H43N5O13. Molecular Weight , 585.61. Storage Temp , +4°C. Harmonized Tariff code , 29419000. Signal Word , ...
According to a new study, failing metal-on-metal hip implants generate toxic nano-particles that release Cobalt 2+ ions, which not only cause inflammation in surrounding tissue, but have the potential to cause long-term damage to the genetic material of cells. According to a report published by Medicalxpress.com, this "genotoxicity" could ... Read More. ...
4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl ]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-3-hydroxy-cyclo hexyl]-2-hydroxy- ...
4-amino-N-[5-amino-2-[4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl ]oxy-4-[6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-3-hydroxy-cyclo hexyl]-2-hydroxy- ...
Study met primary endpoint of culture conversion (p< 0.0001)Positive top-line results from global Phase 3 controlled study in patients with NTM, a rare, progressive, destructive lung infection Company plans to pursue accelerated approval and reques
ISKON REMEDIES / GMT ( GENERAL MACHINE TOOLS) is on a mission to manufacture the finest and widest range of pharmaceutical injectables at the best rates and ensure best of health, which is the real wealth of the nation. We plan to grow, expand, and fulfill client expectations and contribute to the welfare of society. ...
A comparative study of in vitro activity of amikacin, gentamicin, netilmicin, tobramycin and isepamicin was done. A total of 200 clinical isolates of Gram ...
Frequently asked questions. 1. What is the service life of AMK decorative coating?. Nothing will happen to the material itself over time, because it is a natural marble crumb. It is worth paying attention to whether the installation was made correctly and what guarantee is given by the manufacturer of the adhesive mixtures which are used by you.. 2. Is it possible to finish the walls of an old house, building, structure?. Of course, it is possible. The main thing is to prepare the separated surface well, it is necessary to get rid of all slits and irregularities by plastering it. In the same way, the material is applied to brickwork.. 3. Is AMK used in the interior?. Yes, the decorative coating AMK perfectly repeats the brick or stone masonry, which is nowadays increasingly used for interior decoration.. 4. When is it necessary to remove the protective film?. Removing the protective film directly depends on the temperature conditions in which the installation is performed. The film can be ...
Drugs with less than 10 isolates are removed from the chart and from the graph. The following drugs had some data removed: rifampim, amikacin. ...
A 4 months old boy presented with fever and cough for 7 days. His chest X-Ray had shown right upper and mid zone consolidation for which he had received ceftriaxone-sulbactum and amikacin for 7 days but there was no response.
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Sestanek vseh članov AMK Goričko. Vse člane AMK Starodobnih vozil Goričko vabimo na sestanek ob koncu leta 2017, ki bo v nedeljo 10.dec.2017 ob 10.00uri v gostilni Bežan-Žökš pri Gradu.. PRIDIMO Z OLDTIMERJI, KER GREMO OB 12,00uri NA OTVORITEV KROŽIŠČA V MOTOVILCE. Vabljeni. XI. Mednarodni oldtimer vikend Goričko 2017. 17. junij od 8. 00 - 10. 00 ure zbiranje in zajtrk v Kuzmi pri osnovni šoli. Ob 10. 00 start, vožnja v smeri Sotine na Kompas shop Kuzma (postanek), v Avstrijo do Jennersdorfa(postanek), nato preko Madžarske v Martinje (postanek), Grad, Bodonce(postanek). in cilj v Polani, gostišče Lovenjakov dvor. www. lovenjakov-dvor. si. Naše oldtimerke so praznovale 08. marec 2017-Dan žena Danes 08. marca so praznovale naše prijateljice, žene, sopotnice oldtimerke. Bil sem počaščen, da sem lahko bil z še nekaj mojimi klubskimi prijetelji na začetku večera in jim, kot sem že omenil za današnji dan, ki je nekaj posebnega - je dan, posvečen dekletom, ženam, materam, ...
Objective- To compare the in vitro elution characteristics of amikacin and cefazolin from polymethylmethacrylate (PMMA) alone and in combination.. Study Design- A prospective, controlled, experimental study.. Methods- Three aliquots of 6 g sterile PMMA were measured and to them added (1) 750 mg amikacin; (2) 1050 mg cefazolin; and (3) 750 mg amikacin and 1050 mg cefazolin. Ten beads of each antimicrobial/PMMA combination were placed in 5 mL phosphate-buffered saline (PBS) at pH 7.4 and room temperature with constant agitation. PBS was sampled at 15 time points between 1 hour and 30 days. Amikacin concentrations were determined by fluorescence polarization immunoassay and cefazolin concentrations by high-performance liquid chromatography.. Results- Amikacin and cefazolin eluted at concentrations greater than 8 and 4 times, respectively, above the minimum inhibitory concentration (MIC) for susceptible bacteria over 30 days. Co-elution of the antibiotics resulted in a greater rate and proportion of ...
TY - JOUR. T1 - An improved application for the enzyme multipled immunoassay technique for caffeine, amikacin, and methotrexate assays on the Dade-Behring dimension RxL Max clinical chemistry system. AU - Mendu, Damodara Rao. AU - Chou, Peter P.. AU - Soldin, Steven J.. PY - 2007/10/1. Y1 - 2007/10/1. N2 - Caffeine is widely used in childrens hospitals to treat neonatal apnea. Amikacin is used for treating hospital-acquired infections caused by Gram-negative bacteria resistant to other aminoglycosides. The blood levels, however, have to be monitored carefully because of its ototoxicity and nephrotoxicity. Methotrexate (MTX) is used as a chemotherapeutic agent in the treatment of leukemia and lymphoma as well as of certain solid tumors. Current enzyme multiplied immunoassay technique (EMIT) assays for caffeine, amikacin, and MTX lack low-end precision. In addition, the EMIT assays for MTX lack the sensitivity of reliable quantification to 0.05 μmol/L needed because of todays more rigorous ...
... aims at providing comprehensive data on amikacin market globally and regionally (Europe, Asia,
Amikacin//Polymyxin B/Triamcinalone Polox-A-Gel Otic may be prescribed for Dogs with Infection-Bacterial. Amikacin//Polymyxin B/Triamcinalone preparation information is provided by Wedgewood Pharmacy.
Announcement NORTH WALES, Pa. - Teva Pharmaceuticals today announced a voluntary recall of one lot of amikacin sulfate injection USP, 1 gram/4mL (250 m
Bayer today announced that INHALE, a global Phase III clinical study program investigating Amikacin Inhale in addition to standard of care in intubated and mechanically ventilated patients with Gram-negative pneumonia, did not demonstrate superiority vers
Drug information on brand Kacin (100mg) 100mg/1vial (1Vial Injection) (Amikacin). It is manufactured by Modern Laboratories. Find out its price,dose and the nearest pharmacy to buy it.
Drug information on brand Amicap (500mg) 500mg/1vial (1Vial Injection) (Amikacin). It is manufactured by Pax Healthcare. Find out its price,dose and the nearest pharmacy to buy it.
AMIKACIN SULPHATE 20. AMILORIDE HYDROCHLORIDE 21. AMINEPTINE 22. AMINOGLUTETHIMIDE 23. AMINOSALICYLIC ACID ...
cefepime, ceftazidime, imipenem, meropenem or piperacillin-tazobactam; plus ciprofloxacin, levofloxacin, amikacin, gentamicin, ...
Susceptible to amikacin, imipenem, cefoxitin, clarithromycin and ciprofloxacin. Resistant to isoniazid and rifampin. ...
Susceptible to amikacin, azithromycin, ciprofloxacin, clarithromycin and ethambutol. Resistant to isoniazid. Differential ...
Sensitive to compounds such as prothionamide, cycloserine, clarithromycin, gentamicin, amikacin. Resistant to compounds such as ...
... though the role of aminoglycosides such as streptomycin and amikacin has been eclipsed (because of their toxicity and ...
Tobramycin and Amikacin". Expert Review of Anti-infective Therapy. 10 (4): 459-73. doi:10.1586/eri.12.25. PMID 22512755. García ...
c. Third choice: gentamicin or amikacin (both aminoglycosides) +/- amoxicillin or vancomycin (all injectable). Aminoglycosides ... amikacin]) Antibiotics directed against Gram-positive bacteria need to be included in instances and institutions where ...
Aminoglycosides such as tobramycin, gentamicin, and amikacin are other choices for therapy. This ability to thrive in harsh ...
S01AA21 Amikacin. S01AA22 Micronomicin. S01AA23 Netilmicin. S01AA24 Kanamycin. S01AA25 Azidamfenicol. S01AA26 Azithromycin. ...
... is antagonistic to the microbiologic effects of the antibiotics gentamicin and amikacin. Rifampicin inhibits ...
A new combination drug therapy (sulfonamide, ceftriaxone, and amikacin) has also shown promise. The prognosis of nocardiosis is ...
Aminoglycosides such as amikacin have been found to be very effective, as well. Quinolones can be an effective alternative. A ...
Mednje sodijo amikacin, arbekacin, gentamicin, kanamicin, neomicin, netilmicin, paromomicin, rodostreptomicin, streptomicin ...
... i: Kanamicin • Streptomicin • Tobramicin • Neomicin • Paromomicin • Apramicin • Gentamicin • Netilmicin • Amikacin ... Među njima su amikacin, arbekacin, gentamicin, kanamicin, neomicin, netilmicin, paromomicin, rodostreptomicin, streptomicin ...
"In vivo bacterial regrowth-inhibition effect of cefbuperazone and amikacin in puerperal uterine cavity". Journal of ...
Minocycline is usually substituted when a sulfa cannot be given; high-dose imipenem and amikacin have also been used in severe ...
J01GB06 Amikacin. J01GB07 Netilmicin. J01GB08 Sisomicin. J01GB09 Dibekacin. J01GB10 Ribostamicin. J01GB11 Isepamicin. J01GB12 ...
"Refractory Craniofacial Actinomycetoma Due to Streptomyces somaliensis That Required Salvage Therapy with Amikacin and Imipenem ...
"Phase I Pharmacokinetics of Liposomal Amikacin (MiKasome) in Human Subjects: Dose Dependence and Urinary Clearance". Abstr ...
Sampi K, Hattori M (1992). "[Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic ...
... and amikacin are the drugs most often used in clinical trials of once-daily dosing regimens. Ugeskrift for Lægerer. ... amikacin), and it is more expensive; thus, its potential value is limited. Drug Intelligence & Clinical Pharmacy: Vol. 17, No. ...
Antibiotics that have been used to successfully treat C. violaceum include pefloxacin, ciprofloxacin, amikacin, and co- ...
The type strain isolates were susceptible in vitro to ciprofloxacin, amikacin, tobramycin, cefoxitin, clarithromycin, ...
... vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains". Annals of Clinical Microbiology and ...
The concentration of amikacin in the renal cortex becomes ten times that of amikacin in the plasma; it then most likely ... Resistance to amikacin also confers resistance to kanamycin and capreomycin. Resistance to amikacin and kanamycin in ... The elderly tend to have amikacin stay longer in their system; while the average clearance of amikacin in a 20-year-old is 6 L/ ... Treating overdoses of amikacin requires kidney dialysis or peritoneal dialysis, which reduce serum concentrations of amikacin, ...
... has role nephrotoxin (CHEBI:61015) amikacin (CHEBI:2637) is a α-D-glucoside (CHEBI:22390) amikacin (CHEBI ... amikacin (CHEBI:2637) is a carboxamide (CHEBI:37622) amikacin (CHEBI:2637) is conjugate base of amikacin(4+) (CHEBI:84739) ... amikacin (CHEBI:2637) has functional parent kanamycin A (CHEBI:17630) amikacin (CHEBI:2637) has role antibacterial drug (CHEBI: ... Amikacin KEGG COMPOUND O-. 3-. amino-. 3-. deoxy-. α-. D-. glucopyranosyl-. (1→4)-. O-. (6-. amino-. 6-. deoxy-. α-. D- ...
Amikacin Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Use amikacin injection until you finish the prescription, even if you feel better. If you stop using amikacin injection too ... Before receiving amikacin injection,. *tell your doctor and pharmacist if you are allergic to amikacin injection; other ... If you become pregnant while using amikacin injection, call your doctor immediately. Amikacin may harm the fetus. ...
Adverse effects and choice between the Injectable agents amikacin and capreomycin in Multidrug-resistant tuberculosis. ...
If you would like to schedule an appointment with one of our nationally ranked specialists or Primary Care physicians please click or call 800-881-7385.. ...
... is used to treat severe or serious bacterial infections. Amikacin may also be used for purposes not listed in this ... What is amikacin?. Amikacin is an antibiotic that fights bacteria.. Amikacin is used to treat severe or serious bacterial ... What is the most important information I should know about amikacin?. Amikacin can harm your kidneys, and may also cause nerve ... Amikacin is usually given for 7 to 10 days.. Amikacin is injected into a muscle, or into a vein through an IV. You may be shown ...
AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 250 mg in 1 mL. ... AMIKACIN SULFATE (UNII: N6M33094FD) (AMIKACIN - UNII:84319SGC3C) AMIKACIN. 250 mg in 1 mL. ... Amikacin. Sulfate Injection, USP equivalent to amikacin. 1 gram/4 mL. (250 mg/mL). FOR IM OR IV USE 4 mL Vial. Each mL contains ... Amikacin. Sulfate. Injection, USP equivalent to amikacin. 500 mg/2 mL. (250 mg/mL). FOR IM OR IV USE 2 mL Single Dose Vial ...
Erfa-Amikacin. Warning. *This drug may cause kidney, nerve, and hearing problems (like long-lasting hearing loss), even at ... Amikacin (Systemic) - Last updated on August 5, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ... If you have an allergy to amikacin or any other part of this drug. ...
Amikacin (Oral Inhalation) - Generated on April 25, 2019. ©2019 Memorial Sloan Kettering Cancer Center. ...
Easy-to-read patient leaflet for Amikacin (Systemic). Includes indications, proper use, special instructions, precautions, and ... What do I need to tell my doctor BEFORE I take Amikacin?. *If you have an allergy to amikacin or any other part of amikacin ( ... How do I store and/or throw out Amikacin?. *If you need to store amikacin (systemic) at home, talk with your doctor, nurse, or ... How is this medicine (Amikacin) best taken?. Use amikacin (systemic) as ordered by your doctor. Read all information given to ...
Amikacin official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... Amikacin has demonstrated in vitro activity against the following bacteria. The safety and effectiveness of Amikacin in ... PACKAGE LABEL - PRINCIPAL DISPLAY - Amikacin 500 mg Single Dose Vial Label. Amikacin Sulfate Injection, USP. 500 mg per 2 mL ( ... PACKAGE LABEL - PRINCIPAL DISPLAY - Amikacin 500 mg Single Dose Vial Carton Panel. NDC 63323-815-02. Amikacin Sulfate Injection ...
Find patient medical information for Amikacin (PF) Injection on WebMD including its uses, side effects and safety, interactions ... How to use Amikacin (PF) Solution. This medication is given by injection into a vein or muscle as directed by your doctor. It ... Amikacin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/ ... Before using amikacin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such ...
Several forms of amikacin are used currently, including an intravenous (IV) or intramuscular (IM) injection. In September 2018 ... Amikacin also exerts excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, ... Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the ... Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] ...
Find user ratings and reviews for amikacin injection on WebMD including side effects and drug interactions, medication ... Read user comments about the side effects, benefits, and effectiveness of amikacin injection. ...
... amikacin injection suppliers and exporters. These amikacin injection manufacturing companies are offering high quality products ... Amikacin Injection Amikacin injection is used to treat serious bacterial infections in many different parts of the body. This ... AMIKACIN SULFATE INJECTION USP 100MG / 2ML Amikacin injection is used to treat serious bacterial infections in many different ... Amikacin InjectionWe Rewine Pharmaceutical are a leading Manufacturer and Exporter of Amikacin vial in different strength and ...
P stands for Amikacin plus penicillin. A+P is defined as Amikacin plus penicillin very rarely. ... 2018 https://www.acronymfinder.com/Amikacin-plus-penicillin-(A%2bP).html. *Chicago style: Acronym Finder. S.v. "A+P." Retrieved ... APA style: A+P. (n.d.) Acronym Finder. (2018). Retrieved December 14 2018 from https://www.acronymfinder.com/Amikacin-plus- ... a href=https://www.acronymfinder.com/Amikacin-plus-penicillin-(A%2bP).html,A+P,/a,. ...
... sulfate is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. D-Streptamine, O-3-amino-3-deoxy-a-b- ... The 500 mg per 2 mL vial and the 1 gram per 4 mL vial, each mL contains: 250 mg Amikacin(as the sulfate), 0.66% Sodium ... Serum concentrations of amikacin should be monitored when feasible to assure adequate levels and to avoid potentially toxic ... The 100 mg per 2 mL vial, each mL contains: 50 mg Amikacin(as the sulfate), 0.13% Sodium Metabisulfite, 0.5% Sodium Citrate ...
... said on Friday that Amikacin Inhale, an integrated drug-device combination being tested in patients with a type of pneumonia, ... Amikacin Inhale is a drug-device combination product that combines a specially formulated version of the antibiotic amikacin ... Bayers Amikacin Inhale Fails to Meet Objectives in Phase 3 Trial. By Sonia Amaral Rohter. Published November 24, 2017. ... In the study, Amikacin Inhale failed to demonstrate superiority over the placebo and therefore did not meet either the primary ...
van der Auwera, P., de Moor, G., Lacroix, G. et al. In vitro activity of enoxacin compared with norfloxacin and amikacin. Eur. ... In vitro activity of enoxacin compared with norfloxacin and amikacin. *P. van der Auwera. 1. , ... 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. ...
... Sikander A. K. Lodhi,1 G. ... "Postoperative Nocardia Endophthalmitis and the Challenge of Managing with Intravitreal Amikacin," Case Reports in ...
Drug Information available for: Amikacin Amikacin sulfate Genetic and Rare Diseases Information Center resources: Bacterial ... Amikacin Penetration Into the Cerebrospinal Fluid. The safety and scientific validity of this study is the responsibility of ... Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired ... Culture proved bacterial meningitis where the prescribed therapy includes the use of systemic and intraventricular amikacin ...
Amikacin was synthesized by acylation with the l-(−)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the ... The most widely used semisynthetic aminoglycoside is amikacin, which is refractory to most aminoglycoside modifying enzymes. ... Ib and extend the useful life of amikacin. Small molecules as well as complexes ionophore-Zn+2 or Cu+2 were found to inhibit ... deoxystreptamine moiety of kanamycin A. The main amikacin resistance mechanism found in the clinics is acetylation by the ...
Injectable; Injection; Amikacin Sulfate 250 mg / ml*Injectable; Injection; Amikacin Sulfate 50 mg / ml. ...
D06AX12 - Amikacin*J01GB06 - Amikacin*S01AA21 - Amikacin. Pharmaceutical companies: manufacturers, researchers, developers, ... Injectable; Injection; Amikacin 125 mg / ml*Injectable; Injection; Amikacin 250 mg / ml*Injectable; Injection; Amikacin 50 mg ...
InjectionAminoglycosidesAminoglycoside antibioticsPharmacokineticsAntibioticsAllergy to amikacinAntimicrobialSerumIndicationsIsolatesInhalationDosesAntibacterialInjectableMinimum inhibitory concentrationsOtotoxicityGentamicin and amikacinSystemicAeruginosaCeftazidimePlus amikacinIntravitreal AmikacinInfectionsGram negative2018Semisynthetic aminoglycosidePatientsSusceptibilityAmikacinaDoseNephrotoxicitySusceptibleVancomycinNebulizationFormulationsDosageIncluding neonatalMedicationRibosomalNephrotoxicPharmacokineticContraindications
- Your doctor may not want you to receive amikacin injection. (medlineplus.gov)
- If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection. (medlineplus.gov)
- Amikacin injection is used to treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. (medlineplus.gov)
- Amikacin injection is in a class of medications called aminoglycoside antibiotics. (medlineplus.gov)
- Antibiotics such as amikacin injection will not work for colds, flu, or other viral infections. (medlineplus.gov)
- Amikacin injection comes as a liquid to be injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 or 12 hours (two or three times a day). (medlineplus.gov)
- You may receive amikacin injection in a hospital or you may administer the medication at home. (medlineplus.gov)
- If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medication. (medlineplus.gov)
- You should begin to feel better during the first few days of treatment with amikacin injection. (medlineplus.gov)
- Use amikacin injection until you finish the prescription, even if you feel better. (medlineplus.gov)
- If you stop using amikacin injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics. (medlineplus.gov)
- or any of the ingredients in amikacin injection. (medlineplus.gov)
- In people with a CNS infection such as meningitis, amikacin can be given intrathecally (by direct injection into the spine) or intraventricularly (by injection into the ventricles of brain). (wikipedia.org)
- Amikacin sulfate injection, USP is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. (drugs.com)
- Teva Pharmaceuticals based in North Wales, Pennsylvania, announced a voluntary recall of seven lots of Amikacin Sulfate Injection USP, 500 mg/2mL and 1 tram/4mL vials as a result of the potential presence of glass particulate matter. (newsinferno.com)
- Several forms of amikacin are used currently, including an intravenous (IV) or intramuscular (IM) injection. (drugbank.ca)
- The amikacin sulfate injection is indicated in the short-term treatment of serious bacterial infections due to susceptible strains of gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, as well as Acinetobacter (Mima-Herellea) species. (drugbank.ca)
- Read user comments about the side effects, benefits, and effectiveness of amikacin injection. (webmd.com)
- Amikacin Sulphate 500 MG Injection is used to treat a variety of bacterial infections of the lungs, skin, abdomen, and blood caused by E.coli, Streptococci. (tradeindia.com)
- The 500 mg per 2 mL vial and the 1 gram per 4 mL vial, each mL contains: 250 mg Amikacin(as the sulfate), 0.66% Sodium Metabisulfite, 2.5% Sodium Citrate Dihydrate, Water for Injection qs, Air replaced with Nitrogen. (egeneralmedical.com)
- One of the dosage forms available for Amikacin is Injection Solution. (wedgewoodpharmacy.com)
- 5 strengths of Amikacin Injection Solution are available, ranging from 50 mg/ml to 300 mg/ml. (wedgewoodpharmacy.com)
- Pars plana vitreous tap of 0.2 ml was performed followed by injection of 1 mg/0.1 ml of vancomycin and 0.4 mg/0.1 ml of amikacin. (bmj.com)
- Hypotheses for toxicity include dilution errors, raised post-injection intraocular pressure, concomitant use of high concentrations of subconjunctival amikacin, and variations in vitreous concentration. (bmj.com)
- This composition of Injection is a higher dose of Amikacin Sulphate 200 mg which is used to prevent or treat bacterial infections. (iskonremedies.com)
- Amikacin sulfate injection is indicated in the short-term treatment of serious infections. (allofantibiotics.org)
- Aminoglycosides, including amikacin, are not indicated in uncomplicated first-time episodes of urinary tract infections unless the causative organisms are not susceptible to antibiotics which are less toxic. (drugbank.ca)
- The range of antimicrobial movement of amikacin is the biggest of aminoglycosides, has an imperviousness to the compound that inactivates this gathering. (medicinesmexico.com)
- At the point when the strains of the above organic entities are impervious to different aminoglycosides, including gentamicin, tobramycin and kanamycin, may at present be powerless in vitro to amikacin sulfate. (medicinesmexico.com)
- Amikacin is impervious to debasement by most compounds inactivating influencing aminoglycosides gentamycin, kanamycin and tobramycin. (medicinesmexico.com)
- Aminoglycosides, including amikacin sulfate infusion, are not showed for starting scenes of uncomplicated urinary tract diseases unless the causative specialists is not vulnerable to anti-microbials having less potential danger. (medicinesmexico.com)
- We examined resistance in Mycobacterium tuberculosis (MTB) to the deoxystreptamine aminoglycosides amikacin (AK) and kanamycin (KM) in contrast to its resistance to streptomycin (SM), a streptidine drug. (asm.org)
- This medicine is not recommended for use in patients with a known allergy to amikacin, any other aminoglycosides, or any other inactive ingredients present along with it. (practo.com)
- Amikacin belongs to a class of drugs known as aminoglycoside antibiotics . (webmd.com)
- Pharmacology - Amikacin, like the other aminoglycoside antibiotics, act on susceptible bacteria presumably by irreversibly binding to the 30S ribosomal subunit thereby inhibiting protein synthesis. (elephantcare.org)
- Amikacin (aminoglycoside) antibiotics frequently used in the treatment of Gram-negative bacterial infection in neonates, but its usage restricted due to nephrotoxicity and ototoxicity as a major side effect. (alliedacademies.org)
- Aminoglycoside antibiotics such as gentamicin and amikacin may thus be introduced as a treatment regimen for typhoid fever. (who.int)
- Like other aminoglycoside antibiotics, amikacin is mildly neurotoxic and nephrotoxic, i.e. damaging to the brain and kidneys. (healthery.com)
- Amikacin (brand names include: Amikacine / Amikin / Amicin / Amikozit / Biklin / Likacin / Miacin / Selemycin) belongs to a class of drugs known as aminoglycoside antibiotics. (allofantibiotics.org)
- Amikacin pharmacokinetics in patients receiving high-dose cancer chemotherapy. (asm.org)
- We retrospectively analyzed amikacin pharmacokinetics in 28 patients (mean age, 47.4 +/- 13.6 years) who received high-dose chemotherapy during a neutropenic febrile episode. (asm.org)
- The pharmacokinetics of gentamicin, tobramycin, and amikacin in the inner ear fluids and serum of the guinea pig were studied. (springer.com)
- The use of amikacin in the treatment of staphylococcal infections should be restricted only to second-line therapy, and should be limited to only those patients suffering from severe infections caused by susceptible strains of staphylococcus species who have failed to show sensitivity to other available antibiotics. (drugbank.ca)
- Amikacin liposome is given in combination with other antibiotics. (rxlist.com)
- Amikacin liposome is given only to certain adults, when other antibiotics have failed to clear their MAC infections after 6 months of treatment. (rxlist.com)
- Empirical treatment with antibiotics combination has been recommended in severe sepsis and septic shock to reduce mortality such as meropenem and amikacin, meropenem and levofloxacin, and carbapenem (meropenem, imipenem, and doripenem) and polymyxin [ 5 , 6 ]. (hindawi.com)
- This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. (koreascience.or.kr)
- All scaffolds exhibited an initial burst of antibiotics, but groups containing chitosan reduced the burst for amikacin at 1hr by 50%, and vancomycin by 14-25% over the first 2 days. (koreascience.or.kr)
- Amikacin is an antibiotic used to treat a range of severe bacterial infections when other antibiotics have not been able to offer effective treatment. (healthery.com)
- Amikacin is an antibiotic typically used to treat very severe bacterial infections that have not responded to other antibiotics. (healthery.com)
- The most common side effects of amikacin are similar to other antibiotics: nausea and diarrhea, headache and lightheadedness, fatigue, sweating, and joint pain. (healthery.com)
- Serum concentrations of amikacin should be monitored when feasible to assure adequate levels and to avoid potentially toxic levels and prolonged peak concentrations above 35 micrograms per mL. (nih.gov)
- According to our definition of nephrotoxicity (an increase in serum creatinine levels to at least 50 percent and 0.5 mg/dl above the baseline value), nephrotoxicity occurred in eight (15 percent) of the patients who were treated with gentamicin and none of the patients who were treated with amikacin (p = 0.006). (nih.gov)
- Amikacin pharmacokinetic parameters were calculated from two or more concentrations in serum around a single dose by the method of Sawchuck and Zaske (J. Pharmacokinet. (asm.org)
- Administration of dosage regimens based on predicted pharmacokinetic parameters yielded subtherapeutic amikacin concentrations in serum in our patients. (asm.org)
- In healthy, ventilated piglets receiving either intravenous or nebulized amikacin, pulmonary concentrations were found to be about 10 times higher in the nebulization group than in the intravenous group, 10 whereas peak serum concentrations were 4 times lower. (asahq.org)
- The same day, urine and serum amikacin concentrations were determined at different time points. (youscribe.com)
- Results Median (range) ELF amikacin and maximum serum amikacin concentrations were 976.1 (135.7-16127.6) and 0.9 (0.62-1.73) μg/mL, respectively. (youscribe.com)
- Conclusions PDDS delivery of aerosolized amikacin achieved very high aminoglycoside concentrations in ELF from radiography-controlled infection-involved zones, while maintaining safe serum amikacin concentrations. (youscribe.com)
- Immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of amikacin, a semisynthetic aminoglycoside bactericidal agent present in the sample. (ophthalmologymanagement.com)
- Many patients taking amikacin experience high serum creatinine levels, but they virtually always return to normal after stopping treatment. (healthery.com)
- The in vitro activity of enoxacin was tested against 1000 clinical isolates of gram-positive and gram-negative microorganisms and compared with that of norfloxacin and amikacin. (springer.com)
- In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans. (nih.gov)
- MICs of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin were determined for 14 primary clinical isolates and three reference isolates of Mycobacterium ulcerans by modifying a standard agar dilution method for testing Mycobacterium tuberculosis sensitivity. (nih.gov)
- Doripenem sensitive combined with amikacin sensitive reduced MIC significantly in all bacterial isolates when compared to single MIC of each antibiotic. (hindawi.com)
- The rationale for amikacin use relates to the relatively high incidence of Gram negative isolates in endophthalmitis (6.4-26.2%) 3- 5 and the broad spectrum of action with low resistance offered by this agent. (bmj.com)
- The new GenoType Mycobacterium tuberculosis drug resistance second line (MTBDR sl ) assay (Hain Lifescience, Nehren, Germany) was tested on 106 clinical isolates and directly on 64 sputum specimens for the ability to detect resistance to fluoroquinolones, injectable drugs (amikacin or capreomycin), and ethambutol in Mycobacterium tuberculosis strains. (asm.org)
- Results: Two hundred and thirty-four Enterobacteriaceae isolates were found to be more susceptible to amikacin and isepamicin than to gentamicin. (thefreelibrary.com)
- The results revealed that amikacin and isepamicin exerted excellent antibacterial activity (94% vs. 93.6%) against all tested isolates. (thefreelibrary.com)
- sup], It is effective against Gram-negative bacilli, including drug-resistance bacterial isolates, with similar susceptibility to amikacin. (thefreelibrary.com)
- This study assessed the in vitro activity of gentamicin and amikacin against 464 S. enterica serovar Typhi isolates obtained from blood of patients clinically suspected of enteric fever who attended the Calcutta School of Tropical Medicine from 1991 to 2003. (who.int)
- The isolates were sensitive to gentamicin and amikacin, showing minimum inhibitory concentrations 0.01-4 μg/mL and 0.005-3.5 μg/mL respectively. (who.int)
- Amikacin liposome inhalation suspension was approved for the treatment of lung disease caused by a group of bacteria, Mycobacterium avium complex (MAC) in a limited population of patients with the disease who do not respond to conventional treatment (refractory disease). (drugbank.ca)
- Amikacin Inhale is a drug-device combination product that combines a specially formulated version of the antibiotic amikacin with an inhalation system developed by Nektar Therapeutics (NKTR) to deliver the drug to the patient's lungs. (foxbusiness.com)
- Amikacin should be used in smaller doses in the elderly, who often have age-related decreases in kidney function, and children, whose kidneys are not fully developed yet. (wikipedia.org)
- The risk of these problems may be higher if you already have kidney or hearing problems, if you get high doses of amikacin (systemic), or if you get amikacin (systemic) for a long time. (drugs.com)
- Clinical Relevance- Co-elution of amikacin and cefazolin from PMMA at the selected doses cannot be recommended for sustained treatment of infection. (wiley.com)
- The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses to the lungs. (youscribe.com)
- To reduce the development of drug-resistant bacteria and maintain the effectiveness of the amikacin and other antibacterial drugs, amikacin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
- Amikacin is an aminoglycoside antibiotic that exhibits antibacterial efficacy against gram negative bacteria. (lktlabs.com)
- The concurrent use of amikacin with potent diuretics (ethacrynic acid, or furosemide) should be avoided since diuretics by themselves may cause ototoxicity. (nih.gov)
- Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. (nih.gov)
- Fifty-four patients treated with gentamicin and 52 patients treated with amikacin were evaluated for nephrotoxicity and ototoxicity in a prospective, randomized, blinded comparative trail. (nih.gov)
- The Incidence of Amikacin Ototoxicity in Multidrug-Resistant Tuberculosis Patients', Iranian Journal of Pharmaceutical Research , Volume 10(4), pp. 905-911. (ac.ir)
- Amikacin has been shown to irreversibly suppressCochlear activity.The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB) were included.All patients received fixed dose of intravenous amikacin(500 mg/day) and anti-TB medications for six months. (ac.ir)
- However, risk factors' determination and monitoring of audiometric result variations could haveinfluenced the incidence of the amikacin ototoxicity. (ac.ir)
- Hearing loss can happen even after amikacin (systemic) is stopped. (drugs.com)
- Do not use amikacin (systemic) if you are taking or have recently taken any drugs that can cause nerve, kidney, or hearing problems. (drugs.com)
- Very bad muscle problems and very bad breathing problems have happened with amikacin (systemic). (drugs.com)
- You must check to make sure that it is safe for you to take amikacin (systemic) with all of your drugs and health problems. (drugs.com)
- Tell all of your health care providers that you take amikacin (systemic). (drugs.com)
- If you are 65 or older, use amikacin (systemic) with care. (drugs.com)
- If you are pregnant or you get pregnant while taking amikacin (systemic), call your doctor right away. (drugs.com)
- Use amikacin (systemic) as ordered by your doctor. (drugs.com)
- Culture proved bacterial meningitis where the prescribed therapy includes the use of systemic and intraventricular amikacin therapy. (clinicaltrials.gov)
- Here, we investigated the efficacy of exogenously administered synthetic KAMP-10 against amikacin-resistant P. aeruginosa keratitis in a mouse model. (arvojournals.org)
- Corneas of anesthetized C57BL/6 mice were scratched and allowed to heal for 4 h before inoculation of 10 4 CFU (in 5 μl saline) amikacin-resistant P. aeruginosa clinical isolate. (arvojournals.org)
- To solve this problem, pharmacy staff studied the stability of three 5% solutions of vancomycin, amikacin, and ceftazidime prepared in aseptic conditions from parenteral antibiotic solutions. (unboundmedicine.com)
- Ceftazidime and amikacin were diluted in 0.9% sodium chloride and vancomycin in 5% dextrose. (unboundmedicine.com)
- The pH of amikacin (6.51), ceftazidime (6.47), and vancomycin (3.77) remained stable during the 75-day period. (unboundmedicine.com)
- Fortified Antibiotic (vancomycin, Amikacin and Ceftazidime) Eye Drop Stability Assessment at -20 Degrees C]." Journal Francais D'ophtalmologie, vol. 30, no. 8, 2007, pp. 807-13. (unboundmedicine.com)
- 3- 5, 9 It appears that in most studies 2 mg (0.1 ml of 20 mg/ml solution) of ceftazidime has in vitro effectiveness equipotent to or greater than 0.4 mg amikacin. (bmj.com)
- Sikander A. K. Lodhi, G. Ashok Kumar Reddy, and C. Aruna Sunder, "Postoperative Nocardia Endophthalmitis and the Challenge of Managing with Intravitreal Amikacin," Case Reports in Ophthalmological Medicine , vol. 2016, Article ID 2365945, 6 pages, 2016. (hindawi.com)
- We report a case of macular toxicity following the use of intravitreal amikacin for postoperative endophthalmitis, outline mechanisms of retinal toxicity, and offer alternatives to amikacin. (bmj.com)
- Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection. (wikipedia.org)
- Clinical studies have shown amikacin also to be effective in serious, complicated, and recurrent urinary tract infections due to the above organisms. (drugbank.ca)
- Amikacin may be used as initial therapy in suspected gram-negative infections and therapy may be initiated before obtaining the results of susceptibility testing. (drugbank.ca)
- Amikacin in the treatment of hospital infections of the urinary tract caused by gram-negative bacilli resistant to gentamicin. (eurekamag.com)
- Amikacin is used in the treatment of a wide variety of aerobic gram-negative bacteria and also for some gram-positive bacteria. (ophthalmologymanagement.com)
- Amikacin is only particularly effective against two non gram-negative bacteria, staphylococcus and nocardia (which can cause pneumonia and encephalitis). (healthery.com)
- AMIKACIN (CAS 37517-28-5) Market Research Report 2018 aims at providing comprehensive data on amikacin market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
- AMIKACIN (CAS 37517-28-5) Market Research Report 2018 contents were worked out and placed on the website in February, 2018. (marketpublishers.com)
- Please note that AMIKACIN (CAS 37517-28-5) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
- Bayer AG (BAYN.XE) said on Friday that Amikacin Inhale, an integrated drug-device combination being tested in patients with a type of pneumonia, failed to meet the primary objective in a phase 3 trial. (foxbusiness.com)
- The trial was studying Amikacin Inhale in intubated and mechanically ventilated patients with Gram-negative pneumonia. (foxbusiness.com)
- The limited available data precludes establishing an antibiotic regimen in patients suffering from bacterial meningitis after head trauma, or spontaneous bleeding Understanding the disposition of Amikacin administered intrathecally will enable to propose rational treatment of these patients. (clinicaltrials.gov)
- Since amikacin sulfate is show in high focuses in the renal framework, patients ought to be decently hydrated to minimize substance aggravation of the renal tubule. (medicinesmexico.com)
- A multicenter open randomized trial was conducted to compare cefepime monotherapy with cefepime/amikacin combination (dual) therapy in treating febrile neutropenic patients with hematologic disorders. (ebscohost.com)
- Methods Nebulized amikacin (400 mg bid) was delivered to the lungs of 28 mechanically ventilated patients with Gram-negative VAP for 7-14 days, adjunctive to intravenous therapy. (youscribe.com)
- On treatment day 3, 30 minutes after completing aerosol delivery, all the patients underwent bronchoalveolar lavage in the infection-involved area and the ELF amikacin concentration was determined. (youscribe.com)
- The incidence of hearing loss was remarkable in MDR-TB patients treating with amikacin. (ac.ir)
- Patients will be treated three consecutive days with inhaled amikacin or placebo. (ichgcp.net)
- Reagents for measuring amikacin levels are used monitor the therapeutic drug levels in patients undergoing treatment, either to determine the adequacy of drug treatment or to diagnose a drug overdose or antibiotic-related toxicity. (ophthalmologymanagement.com)
- However, amikacin can cause very serious side effects in some patients. (healthery.com)
- Hearing loss from amikacin is very uncommon and typically negligible, but patients who lose their hearing from the drug typically never recover it. (healthery.com)
- In addition to threatening hearing, amikacin can also, in rare cases, damage patients' nerves. (healthery.com)
- Patients taking amikacin should contact their doctor immediately if they experience numbness, muscle twitching, or vertigo. (healthery.com)
- One trial suggested that nearly a quarter of patients using amikacin experienced a temporarily reduction in kidney function. (healthery.com)
- A total of 63 strains harboring fluoroquinolone, amikacin/capreomycin, or ethambutol resistance and 43 fully susceptible strains were comparatively analyzed with the new MTBDR sl assay, by DNA sequencing, and by conventional drug susceptibility testing in liquid and solid media. (asm.org)
- Comparison of susceptibility of Enterobacteriaceae causing community-onset urinary tract infection to isepamicin and amikacin by the disc diffusion method. (thefreelibrary.com)
- The aim of this study was to evaluate the susceptibility of clinically isolated Enterobacteriaceae to isepamicin and amikacin using disc diffusion method. (thefreelibrary.com)
- The susceptibility of tested isolated to isepamicin measured by disc diffusion method is comparable to that of amikacin. (thefreelibrary.com)
- To investigate the susceptibility to gentamicin, amikacin and ciprofloxacin and the presence of some aminogloycoside modifying enzyme (AMEs) among nosocomial strains of K pneumoniae subspecie pneumoniae producing ESBL. (eurekamag.com)
- Call your doctor for instructions if you miss a dose of amikacin. (rexhealth.com)
- Amikacin group demonstrated the low level of Glutathione Peroxidase (GPx) and the treatment with piceatannol significantly increase the level of GPx at dose dependent manner. (alliedacademies.org)
- The level of the insulin like growth factor-1 was higher in the Amikacin control group rats, which was significantly reduced by the piceatannol at the dose-dependent manner, but the level of insulin like growth factor-1 was not reached near the normal control. (alliedacademies.org)
- The current study was concluded to examine the possible potential effect of piceatannol on nephrotoxicity induced by Amikacin in neonatal rats. (alliedacademies.org)
- Amikacin-induced nephrotoxicity is associated with oxidative stress and is confirmed by histopathological and biochemical findings. (alliedacademies.org)
- Piceatannol can be beneficial renal protective agents for modulating the amikacin-induced nephrotoxicity in neonates. (alliedacademies.org)
- During the study period, daily through amikacin measurements were below the level of nephrotoxicity. (youscribe.com)
- Results- Amikacin and cefazolin eluted at concentrations greater than 8 and 4 times, respectively, above the minimum inhibitory concentration (MIC) for susceptible bacteria over 30 days. (wiley.com)
- documented infection of mycobacterial organisms susceptible to amikacin. (pediatriconcall.com)
- While amikacin is less susceptible to this effect, it is usually recommended to avoid mixing these compounds together in the same syringe or IV bag, unless administration occurs promptly. (elephantcare.org)
- OBJECTIVE : To determine the effects of regional or general anaesthesia on the clinical and synovial pharmacokinetic parameters of amikacin administered by IV-RLP to horses. (up.ac.za)
- Synovial fluid amikacin concentrations were measured over 24 h and regional pharmacokinetic parameters calculated. (up.ac.za)
- RESULTS : Amikacin concentrations and regional pharmacokinetic parameters did not differ significantly among treatments. (up.ac.za)
- CONCLUSIONS : Perineural regional anaesthesia before IV-RLP was most effective in providing comfort to standing, sedated horses without significantly affecting the regional pharmacokinetic parameters of amikacin. (up.ac.za)