AmidinesBenzamidines: Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.Lyases: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Chondroitin Lyases: Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides containing 1,4-beta-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages thereby bringing about depolymerization. EC 4.2.2.4 acts on chondroitin sulfate A and C as well as on dermatan sulfate and slowly on hyaluronate. EC 4.2.2.5 acts on chondroitin sulfate A and C.Furans: Compounds with a 5-membered ring of four carbons and an oxygen. They are aromatic heterocycles. The reduced form is tetrahydrofuran.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Pectobacterium chrysanthemi: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that causes vascular wilts on a wide range of plant species. It was formerly named Erwinia chrysanthemi.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chondroitinases and Chondroitin Lyases: Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which catalyze the hydrolysis of sulfate groups of the 2-acetamido-2-deoxy-D-galactose 6-sulfate units of chondroitin sulfate. EC 4.2.2.-.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.Phycobiliproteins: Light harvesting proteins found in phycobilisomes.Chicory: A thick-rooted perennial (Cichorium intybus) native to Europe but widely grown for its young leaves used as salad greens and for its roots, dried and ground-roasted, used to flavor or adulterate coffee. (From Webster, 3d ed)Aldehyde-Lyases: Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Carbon-Oxygen Lyases: Enzymes that catalyze the cleavage of a carbon-oxygen bond by means other than hydrolysis or oxidation. EC 4.2.Erwinia: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms are associated with plants as pathogens, saprophytes, or as constituents of the epiphytic flora.Heparin Lyase: An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. (From Enzyme Nomenclature, 1992) EC 4.2.2.7.Oxo-Acid-Lyases: Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.Polygalacturonase: A cell wall-degrading enzyme found in microorganisms and higher plants. It catalyzes the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. EC 3.2.1.15.Alginates: Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.Hexuronic Acids: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.Isocitrate Lyase: A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and glyoxylate. EC 4.1.3.1.Rhodophyta: Plants of the division Rhodophyta, commonly known as red algae, in which the red pigment (PHYCOERYTHRIN) predominates. However, if this pigment is destroyed, the algae can appear purple, brown, green, or yellow. Two important substances found in the cell walls of red algae are AGAR and CARRAGEENAN. Some rhodophyta are notable SEAWEED (macroalgae).Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Phycobilins: Open chain tetrapyrroles that function as light harvesting chromophores in PHYCOBILIPROTEINS.Chondroitin ABC Lyase: An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. (Enzyme Nomenclature, 1992)Sphingomonas: A genus of gram-negative, aerobic, rod-shaped bacteria characterized by an outer membrane that contains glycosphingolipids but lacks lipopolysaccharide. They have the ability to degrade a broad range of substituted aromatic compounds.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cytochromes c1: The 30-kDa membrane-bound c-type cytochrome protein of mitochondria that functions as an electron donor to CYTOCHROME C GROUP in the mitochondrial and bacterial RESPIRATORY CHAIN. (From Enzyme Nomenclature, 1992, p545)Bacteroides: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.Flavobacterium: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in SOIL and WATER. Its organisms are also found in raw meats, MILK and other FOOD, hospital environments, and human clinical specimens. Some species are pathogenic in humans.Adenylosuccinate Lyase: An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.Streptococcus anginosus: A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is the most frequently seen isolate of that group, has a proclivity for abscess formation, and is most often isolated from the blood, gastrointestinal, and urogenital tract.Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.Hevea: A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. Commercial natural RUBBER is mainly obtained from Hevea brasiliensis but also from some other plants.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Proteus vulgaris: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in soil, fecal matter, and sewage. It is an opportunistic pathogen and causes cystitis and pyelonephritis.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Uronic Acids: Acids derived from monosaccharides by the oxidation of the terminal (-CH2OH) group farthest removed from the carbonyl group to a (-COOH) group. (From Stedmans, 26th ed)Chondroitin Sulfates: Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate.Sulfonium Compounds: Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.Glycoside HydrolasesDermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Bacterial Proteins: Proteins found in any species of bacterium.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Carbon-Nitrogen Lyases: Enzymes that catalyze the cleavage of a carbon-nitrogen bond by means other than hydrolysis or oxidation. Subclasses are the AMMONIA-LYASES, the AMIDINE-LYASES, the amine-lyases, and other carbon-nitrogen lyases. EC 4.3.Disaccharides: Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.Carbon-Carbon Lyases: Enzymes that catalyze the cleavage of a carbon-carbon bond by means other than hydrolysis or oxidation. This subclass contains the DECARBOXYLASES, the ALDEHYDE-LYASES, and the OXO-ACID-LYASES. EC 4.1.DNA-(Apurinic or Apyrimidinic Site) Lyase: A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.Kinetics: The rate dynamics in chemical or physical systems.Pseudomonas: A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.N-Glycosyl Hydrolases: A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Kinetic and inhibition studies on substrate channelling in the bifunctional enzyme catalysing C-terminal amidation. (1/31)

A series of experiments has been conducted to investigate the possibility that substrate channelling might occur in the bifunctional forms of enzymes carrying out C-terminal amidation, a post-translational modification essential to the biological activity of many neuropeptides. C-terminal amidation entails sequential action by peptidylglycine mono-oxygenase (PAM, EC 1.14.17.3) and peptidylamidoglycolate lyase (PGL, EC 4.3.2.5), with the mono-oxygenase catalysing conversion of a glycine-extended pro-peptide into the corresponding alpha-hydroxyglycine derivative, which is then converted by the lyase into amidated peptide plus glyoxylate. Since the mono-oxygenase and lyase reactions exhibit tandem reaction stereospecificities, channelling of the alpha-hydroxy intermediate might occur, as is the case for some other multifunctional enzymes. Selective inhibition of the mono-oxygenase domain by competitive ester inhibitors, as well as mechanism-based mono-oxygenase inactivation by the novel olefinic inhibitor 5-acetamido-4-oxo-6-phenylhex-2-enoate (N-acetylphenylalanyl acrylate), has little to no effect on the kinetic parameters of the lyase domain of the AE from Xenopus laevis. Similarly, inhibition of the lyase domain by the potent dioxo inhibitor 2,4-dioxo-5-acetamido-6-phenylhexanoate has little effect on the activity of the monooxygenase domain in the bifunctional enzyme. A series of experiments on intermediate accumulation and conversion were also carried out, along with kinetic investigations of the reactivities of the monofunctional and bifunctional forms of PAM and PGL towards substrates and inhibitors. Taken together, the results demonstrate the kinetic independence of the mono-oxygenase and lyase domains, and provide no evidence for substrate channelling between these domains in the bifunctional amidating enzyme.  (+info)

Kinetic and stereochemical studies on novel inactivators of C-terminal amidation. (2/31)

C-terminal amidation, a required post-translational modification for the bioactivation of many neuropeptides, entails sequential enzymic action by peptidylglycine alpha-mono-oxygenase (PAM, EC 1.14.17.3) and peptidylamidoglycolate lyase (PGL, EC 4.3.2.5). Here we introduce novel compounds in which an olefinic functionality is incorporated into peptide analogues as the most potent turnover-dependent inactivators of PAM. Kinetic parameters for PAM inactivation by 4-oxo-5-acetamido-6-phenyl-hex-2-enoic acid and 4-oxo-5-acetamido-6-(2-thienyl)-hex-2-enoic acid were obtained by using both the conventional dilution assay method and the more complex progress curve method. The results obtained from the progress curve method establish that these compounds exhibit the kinetic characteristics of pure competitive inactivators (i.e. no ESI complex forms during inactivation). On the basis of k(inact)/K(i) values, 4-oxo-5-acetamido-6-(2-thienyl)-hex-2-enoic acid is almost two orders of magnitude more potent than benzoylacrylate, a chemically analogous olefinic inactivator that lacks the peptide moiety. Stereochemical studies established that PAM inactivation by 4-oxo-5-acetamido-6-(2-thienyl)-hex-2-enoic acid is stereospecific with respect to the moiety at the P(2) position, which is consistent with previous results with substrates and reversible inhibitors. In contrast, 2, 4-dioxo-5-acetamido-6-phenylhexanoic acid, which is a competitive inhibitor with respect to ascorbate, exhibits a low degree of stereospecificity in binding to the ascorbate sites of both PAM and dopamine-beta-hydroxylase.  (+info)

Urea is a product of ureidoglycolate degradation in chickpea. Purification and characterization of the ureidoglycolate urea-lyase. (3/31)

A ureidoglycolate-degrading activity was analyzed in different organs of chickpea (Cicer arietinum). Activity was detected in all the tissues analyzed, but highest levels of specific activity were found in pods, from which it has been purified and characterized. This is the first ureidoglycolate-degrading activity that has been purified to homogeneity from any photosynthetic organism. Only one ureidoglycolate-degrading activity was found during the purification. The enzyme was purified 1,500-fold, and specific activity for the pure enzyme was 8.6 units mg(-1), which corresponds with a turnover number of 1,600 min(-1). The native enzyme has a molecular mass of 180 kD and consists of six identical or similar-sized subunits of 31 kD each. The enzyme exhibited hyperbolic, Michaelian kinetics for (-) ureidoglycolate with K(m) values of 6 and 10 microM in the presence or absence of Mn(2+), respectively. Optimum pH was between 7 and 8 and maximum activity was found at temperatures above 70 degrees C, the enzyme being extremely stable and resistant to heat denaturation. The activity was inhibited by EDTA and enhanced by several bivalent cations, thus suggesting that the enzyme is a metalloprotein. This enzyme has been characterized as a ureidoglycolate urea-lyase (EC 4.3.2.3), which catalyzes the degradation of (-) ureidoglycolate to glyoxylate and urea. This is the first time that such an activity is detected in plant tissues. A possible function for this activity and its implications in the context of nitrogen mobilization in legume plants is also discussed.  (+info)

Pathways for urea production during early life of an air-breathing teleost, the African catfish Clarias gariepinus Burchell. (4/31)

Embryos and larvae of the African catfish Clarias gariepinus excrete significant quantities of urea. The present study focused on the potential urea-generating pathways during early development of this teleost; uricolysis, argininolysis and the ornithine-urea cycle (OUC). Uricase, allantoinase, allantoicase and ureidoglycollate lyase of the uricolytic pathway were expressed in all early life stages and in adult liver of C. gariepinus. Uricase activity increased in starved larvae compared with yolk-sac larvae. The key regulatory enzyme of the teleost OUC, carbamoyl phosphate synthetase III (CPSase III), was expressed predominantly in muscle of developing C. gariepinus larvae and showed negligible activity in the absence of its allosteric effector N-acetyl-L-glutamate. CPSase III and ornithine carbamoyl transferase activities increased in fed larvae compared with starved larvae. In contrast to the early developmental stages, adult C. gariepinus expressed only low and variable levels of CPSase III, suggesting that, under the experimental conditions employed, OUC expression is influenced by developmental stage in this species. The data indicate that early C. gariepinus life stages express the enzymes necessary for urea production by uricolysis, argininolysis and the OUC, and this may explain why urea tissue levels and urea excretion rates are substantial during the early development of this air-breathing teleost.  (+info)

Catalysis, stereochemistry, and inhibition of ureidoglycolate lyase. (5/31)

Ureidoglycolate lyase (UGL, EC 4.3.2.3) catalyzes the breakdown of ureidoglycolate to glyoxylate and urea, which is the final step in the catabolic pathway leading from purines to urea. Although the sequence of enzymatic steps was worked out nearly 40 years ago, the stereochemistry of the uric acid degradation pathway and the catalytic properties of UGL have remained very poorly described. We now report the first direct investigation of the absolute stereochemistry of UGL catalysis. Using chiral chromatographic analyses with substrate enantiomers, we demonstrate that UGL catalysis is stereospecific for substrates with the (S)-hydroxyglycine configuration. The first potent competitive inhibitors for UGL are reported here. These inhibitors are compounds which contain a 2,4-dioxocarboxylate moiety, designed to mimic transient species produced during lyase catalysis. The most potent inhibitor, 2,4-dioxo-4-phenylbutanoic acid, exhibits a KI value of 2.2 nM and is therefore among the most potent competitive inhibitors ever reported for a lyase enzyme. New synthetic alternate substrates for UGL, which are acyl-alpha-hydroxyglycine compounds, are described. Based on these alternate substrates, we introduce the first assay method for monitoring UGL activity directly. Finally, we report the first putative primary nucleotide and derived peptide sequence for UGL. This sequence exhibits a high level of similarity to the fumarylacetoacetate hydrolase family of proteins. Close mechanistic similarities can be visualized between the chemistries of ureidoglycolate lyase and fumarylacetoacetate hydrolase catalysis.  (+info)

Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. (6/31)

We have isolated a second gene (MLS1), which in addition to DAL7, encodes malate synthase from S. cerevisiae. Expression of the two genes is specific for their physiological roles in carbon and nitrogen metabolism. Expression of MLS1, which participates in the utilization of non-fermentable carbon sources, is sensitive to carbon catabolite repression, but nearly insensitive to nitrogen catabolite repression. DAL7, which participates in catabolism of the nitrogenous compound allantoin, is insensitive to carbon catabolite repression, but highly sensitive to nitrogen catabolite repression. Results obtained with null mutations in these genes suggest that S. cerevisiae contains at least one and perhaps two additional malate synthase genes.  (+info)

The source of the oxygen atom in the alpha-hydroxyglycine intermediate of the peptidylglycine alpha-amidating reaction. (7/31)

Peptidylglycine alpha-amidating activity catalyses the oxidation of a C-terminally glycine-extended peptide to a desglycine alpha-amidated peptide at the expense of ascorbate and O2 in the presence of Cu2+. The reaction involves oxidative N-dealkylation within the terminal glycine residue, with retention of the glycine N atom and release of the remainder as glyoxylate. Recent studies by us and others have revealed that the reaction consists of two steps via a carbinolamide as an intermediate (peptidyl alpha-hydroxyglycine), and also that two separate enzymes derived from a common precursor protein catalyse these steps, formation of the carbinolamide and its conversion into alpha-amide and glyoxylate. As for the mechanism of carbinolamide formation, two distinct pathways can be considered: direct mono-oxygenation at the glycine alpha-C atom and dehydrogenation leading to an imine followed by hydration. To draw a distinction between them, we carried out the reaction with D-Tyr-Val-Gly as the substrate either in the H2(18)O-enriched medium or under an atmosphere of 18O2, and isolated the alpha-hydroxylglycine intermediate. The fast-atom-bombardment mass-spectral analysis demonstrated that the hydroxy O atom comes from O2, but not from H2O, indicating that the alpha-hydroxylation should be a monooxygenase reaction.  (+info)

Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing. (8/31)

 (+info)

*Peptidylamidoglycolate lyase

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is ... peptidyl-alpha-hydroxyglycine alpha-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase. Katopodis ... In enzymology, a peptidylamidoglycolate lyase (EC 4.3.2.5) is an enzyme that catalyzes the chemical reaction ... peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming). Other names in common use include alpha-hydroxyglycine ...

*Purine imidazole-ring cyclase

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6- ... 9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming). Chetsanga CJ, ... diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5- ...

*Ureidoglycolate lyase

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is (S)- ... In enzymology, an ureidoglycolate lyase (EC 4.3.2.3) is an enzyme that catalyzes the chemical reaction (S)-ureidoglycolate ⇌ {\ ... ureidoglycolate urea-lyase. This enzyme participates in purine metabolism. Trijbels F, Vogels GD (1967). "Allantoate and ... ureidoglycolate urea-lyase (glyoxylate-forming). Other names in common use include ureidoglycolatase, ureidoglycolase, ...

*List of MeSH codes (D08)

... tyrosine phenol-lyase MeSH D08.811.520.232.300 --- amidine-lyases MeSH D08.811.520.232.300.200 --- adenylosuccinate lyase MeSH ... oxo-acid-lyases MeSH D08.811.520.224.600.200 --- anthranilate synthase MeSH D08.811.520.224.600.700 --- isocitrate lyase MeSH ... ethanolamine ammonia-lyase MeSH D08.811.520.232.400.500 --- histidine ammonia-lyase MeSH D08.811.520.232.400.600 --- l-serine ... lyase MeSH D08.811.520.241.300 --- hydro-lyases MeSH D08.811.520.241.300.050 --- aconitate hydratase MeSH D08.811.520.241. ...

*List of enzymes

EC 4.3.1 Phenylalanine ammonia-lyase (EC 4.3.1.24) Category:EC 4.4.1 Cystathionine gamma-lyase Cystathionine beta-lyase ... In linear amidines) Arginase (EC 3.5.3.1) Category:EC 3.5.4 (In cyclic amidines) Adenosine deaminase (EC 3.5.4.4) GTP ...
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting.
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilization of allantoin as sole nitrogen source. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate.
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RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as steroid 17alpha-monooxygenase TAK-700, when used with other hormone therapy, may lessen the amount of androgens made by the body. Radiation therapy uses high energy x rays to kill tumor cells. This may be an effective treatment for prostate cancer when combined with hormone therapy. Studying quality-of-life in patients having cancer treatment may help identify the intermediate- and long-term effects of treatment on patients with prostate cancer.. PURPOSE: This randomized phase III trial is studying the use of hormone therapy, including TAK-700, together with radiation therapy in treating patients with prostate cancer. ...
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as steroid 17alpha-monooxygenase TAK-700, when used with other hormone therapy, may lessen the amount of androgens made by the body. Radiation therapy uses high energy x rays to kill tumor cells. This may be an effective treatment for prostate cancer when combined with hormone therapy. Studying quality-of-life in patients having cancer treatment may help identify the intermediate- and long-term effects of treatment on patients with prostate cancer.. PURPOSE: This randomized phase III trial is studying the use of hormone therapy, including TAK-700, together with radiation therapy in treating patients with prostate cancer. ...
Orteronel (racemic) is a mixture of S-Orteronel and R-Orteronel isomers. Orteronel, aslo known as TAK-700, is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.
Get Details of Amidation Manufacturers,Amidation Suppliers,Amidation Dealers, Amidation Exporters, Amidation Traders, Amidation Producers, Amidation Wholesalers, Amidation Companies
peptidylglycine monooxygenase: forms alpha-amide from C-terminal glycine precursor of peptide hormones by oxidation of hydrogen & spontaneous hydrolysis of resulting imino linkage; posseses both an alpha-hydroxylation domain (PHM) and an alpha-amidation domain (PAL); PAM refers to the bifunctional enzyme; may be the same as bovine Somatotropin; RefSeq NM_013626 (mouse), NM_013000 (rat), NM_138822 (human)
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
ID ALLD_ECO57 Reviewed; 349 AA. AC P58408; DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot. DT 16-NOV-2001, sequence version 1. DT 05-JUL-2017, entry version 95. DE RecName: Full=Ureidoglycolate dehydrogenase (NAD(+)) {ECO:0000250,UniProtKB:P77555}; DE EC=1.1.1.350 {ECO:0000250,UniProtKB:P77555}; GN Name=allD {ECO:0000250,UniProtKB:P77555}; Synonyms=glxB8; GN OrderedLocusNames=Z0672, ECs0579; OS Escherichia coli O157:H7. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=83334; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC; RX PubMed=11206551; DOI=10.1038/35054089; RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., RA Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., RA Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L., RA Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K., RA Apodaca J., Anantharaman T.S., Lin ...
Study Flashcards On PHM 350 Exam II at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
0141] The examples include 5,6-bis[4-(10-phenyl-9-anthryl)phenyl]-2,2-bipyridine (abbreviation: PAP2BPy), 5,6-bis[4-(10-phenyl-9-anthryl)biphenyl-4-yl]-2,2-bipyridine (abbreviation: PAPP2BPy), N,N-diphenyl-N,N-bis[4-(9-phenyl-9H-fluoren-9-yl)phenyl]pyrene-1,6-diam- ine (abbreviation: 1,6FLPAPrn), N,N-bis(3-methylphenyl)-N,N-bis[3-(9-phenyl-9H-fluoren-9-yl)phenyl]pyren- e-1,6-diamine (abbreviation: 1,6mMemFLPAPrn), N,N-bis[4-(9H-carbazol-9-yl)phenyl]-N,N-diphenylstilbene-4,4-diamine (abbreviation: YGA2S), 4-(9H-carbazol-9-yl)-4-(10-phenyl-9-anthryl)triphenylamine (abbreviation: YGAPA), 4-(9H-carbazol-9-yl)-4-(9,10-diphenyl-2-anthryl)triphenylamine (abbreviation: 2YGAPPA), N,9-diphenyl-N-[4-(10-phenyl-9-anthryl)phenyl]-9H-carbazol-3-amine (abbreviation: PCAPA), perylene, 2,5,8,11-tetra(tert-butyl)perylene (abbreviation: TBP), 4-(10-phenyl-9-anthryl)-4-(9-phenyl-9H-carbazol-3-yl)triphenylamine (abbreviation: PCBAPA), ...
Peptidylglycine alpha-Amidating Monooxygenase/PAM Overexpression Lysate (Native). Tested Reactivity: Hu. Validated: WB. Backed by our 100% Guarantee.
Vesicular transport within the secretory pathway can be arrested by incubating cells at 15 degrees C or 20 degrees C to block exit from the endoplasmic reticulum or trans-Golgi network, respectively. Using this powerful tool we have compared the intracellular sites of endoproteolytic processing of proopiomelanocortin and two prohormone processing enzymes in AtT-20 mouse pituitary corticotrope tumor cells. For comparison, proopiomelanocortin processing was also evaluated in primary neurointermediate pituitary cultures. AtT-20 cells synthesize and store endogenous proopiomelanocortin and prohormone convertase 1; AtT-20 cells expressing high levels of integral membrane or soluble peptidylglycine alpha-amidating monooxygenase were generated by stable transfection. Cells were incubated with [35S]methionine and chased at 4 degrees C, 15 degrees C, 20 degrees C or 37 degrees C. The endoproteolytic processing of peptidylglycine alpha-amidating mono-oxygenase, prohormone convertase 1, and ...
PAM - PAM (untagged)-Human peptidylglycine alpha-amidating monooxygenase (PAM) transcript variant 5 available for purchase from OriGene - Your Gene Company.
PAM - PAM (untagged)-Human peptidylglycine alpha-amidating monooxygenase (PAM), transcript variant 2 available for purchase from OriGene - Your Gene Company.
Katapodis, A.G., Ping, D. and May, S.W. (1990). „A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of α-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine α-amidating monooxygenase in peptide amidation". Biochemistry. 29: 6115-6120. PMID 2207061 ...
Antoniou, Josephina, Koukoutsidis, Ioannis, Jaho, Eva, Pitsillides, Andreas and Stavrakakis, Ioannis (2009) Access network synthesis game in next generation networks. Computer Networks, 53 (15). pp. 2716-2726. ISSN 13891286 Barstow, M. A., Burleigh, M. R., Bannister, N. J., Lapington, J. S., Kowalski, M. P., Cruddace, R. G., Wood, K. S., Auchere, F., Bode, M. F. et al (2009) Stellar and galactic environment survey (SAGE). Astrophysics and Space Science, 320 (1-3). pp. 231-238. ISSN 0004-640X Bhatti, S and Bateman, Martin (2009) Transport Protocol Throughput Fairness. Journal of Networks, 4 (9). pp. 881-894. ISSN 1796-2056 Burgaz, Engin, Lian, Huiqin, Alonso, Rafael Herrera, Estevez, Luis, Kelarakis, Antonios and Giannelis, Emmanuel P. (2009) Nafion-clay hybrids with a network structure. Polymer, 50 (11). pp. 2384-2392. ISSN 00323861 Dennison, Sarah Rachel, Harris, Frederick, Bhatt, Tailap, Singh, Jaipaul and Phoenix, David Andrew (2009) The effect of C-terminal amidation on the efficacy and ...
M-Sten is a product containg Methylstenbolone. Considered as the safer and more user-friendly alternative to Superdrol. Results after a couple of weeks. Lean muscle gains up to 25 pounds in 4 weeks have been logged for this compound. Chances of
Magma: Magma, molten or partially molten rock from which igneous rocks form. It usually consists of silicate liquid, although carbonate and sulfide melts occur as well. Magma
Carbamazepina Magma is a medicine available in a number of countries worldwide. A list of US medications equivalent to Carbamazepina Magma is available on the Drugs.com website.
Ratios of Ni to Fe in BIF changed at 2.7 by when the Earth changed from a mafic driven magma driven system(Fe Mg Si O (these magmas also would have Ni)) to one that was more felsic (Na Ca Al Si O). ...
Our recent research results on the novel catalyst for amidation were described in C&EN (Jan. 30th, 2017) , Mainichi Shimbun (Jan. 31st, 2017), and Nikkei Sangyo Shimbun (Jan. 31st, 2017).. Jun. 24. 2016 ...
kgkdg,pe yg kte rs,sukar bnar org nk phm... ni ler gunenyer coretan... cey.. wat madah2 sndiri nih..hee... sebait ayat da boley mggambarkn skeping hati yg tlus :-) ...
The posttranslational processing enzyme peptidylglycine alpha-amidating monooxygenase (PAM) occurs naturally in integral membrane and soluble forms. With the goal of understanding the targeting of these proteins to secretory granules, we have compared the maturation, processing, secretion, and storage of PAM proteins in stably transfected AtT-20 cells. Integral membrane and soluble PAM proteins exit the ER and reach the Golgi apparatus with similar kinetics. Biosynthetic labeling experiments demonstrated that soluble PAM proteins were endoproteolytically processed to a greater extent than integral membrane PAM; this processing occurred in the regulated secretory pathway and was blocked by incubation of cells at 20 degrees C. 16 h after a biosynthetic pulse, a larger proportion of soluble PAM proteins remained cell-associated compared with integral membrane PAM, suggesting that soluble PAM proteins were more efficiently targeted to storage granules. The nonstimulated secretion of soluble PAM ...
View Notes - GEOL101 - Slideshow 101.10 Magma from GEOL 101 at Central Washington University. Magma Magma Melting Crystallization Processes that impact composition Magma Creation of
One backgrounding field study was conducted at two locations to compare the health and performance of high-risk receiving steers given an ExpressTM 5-Pasteurella Haemolytica- Multocida (PHM) vaccine or a Titanium® 5-PHM Bac®-1 vaccine. At one location, calves given the Titanium 5-PHM vaccination had fewer first and second repulls (P,0.05). At the other location, calves given the Express 5-PHM vaccination had fewer initial pulls for respiratory disease and more hospital pen days at initial pull (P,0.05) than those given Titanium 5-PHM. No differences were measured at either location for mortality and average daily gain ...
1] Volcanic eruptions are often accompanied by spatiotemporal migration of ground deformation, a consequence of pressure changes within magma reservoirs and pathways. We modeled the propagation of pressure variations through the east rift zone (ERZ) of K̄lauea Volcano, Hawaii, caused by magma withdrawal during the early eruptive episodes (1983-1985) of the ongoing Puu Ōō-Kupaianaha eruption. Eruptive activity at the Puu Ōō vent was typically accompanied by abrupt deflation that lasted for several hours and was followed by a sudden onset of gradual inflation once the eruptive episode had ended. Similar patterns of deflation and inflation were recorded at K̄laueas summit, approximately 15 km to the northwest, albeit with time delays of hours. These delay times can be reproduced by modeling the spatiotemporal changes in magma pressure and flow rate within an elastic-walled dike that traverses K̄laueas ERZ. Key parameters that affect the behavior of the magma-dike system are the dike ...
VitaDigest offer Magma Plus Powder 11 oz , Product Review For Green Foods Formula and Information, Exclusive Reivews for Magma Plus Powder 11 oz Green Foods
Drugs that inhibit rate-limiting enzymes have important uses as experimental tools and therapeutic agents. The findings presented here demonstrate that PBA inhibits circulating and tissue PHM and thus offers a pharmacological approach for investigating the regulation and function of this rate-limiting enzyme. Although significant advances have been made in our understanding of PHM in neural and endocrine tissues, virtually nothing is known about the physiology of blood-borne PHM, the form most profoundly inhibited by PBA treatment. Thus, PBA may prove to be especially useful in defining the functions of circulating PHM, in addition to increasing our understanding of PHM in peptidergic tissues.. Although the functions of blood-borne PHM remain to be determined, levels of circulating PHM are significant (Eipper et al., 1985; Wand et al., 1985; Ogonowski et al., 1997), and, as shown here, its turnover appears to be rapid. Several α-amidated peptides have been implicated in the control of ...
Im neat and tidy, a well housebroken Australian male who has just got a new job as a full time electrical technician with UGL in Sydney. I surf to keep fit and love to chat to and meet new people. ...
به منظور بررسی قابلیت آزمون جوانه زنیاستاندارد برای پیش بینی ظاهر شدن و استقرار گیاهچه بذر نخود در مزرعه، آزمایشی در دو مرحله بر روی 13 توده بذر نخود در آزمایشگاه و مزرعه تحقیقاتی پردیس کشاورزی و منابع طبیعی دانشگاه رازی کرمانشاه در سال زراعی 1391 انجام شد. در آزمایشگاه سیزده توده بذر نخود متعلق به هفت رقم در قالب طرح کامل تصادفی در 4 تکرار به از روش انجمن بین المللی آزمون بذر (ISTA) تحت آزمون جوانه زنی استاندارد قرار گرفتند. در این آزمون‌ شاخص‌های مرتبط با بنیه بذر و گیاهچه اندازه‌گیری شدند. در مزرعه با استفاده از طرح بلوک های کامل تصادفی با چهار تکرار فاکتورهای
K00498 CYP11A; cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6] K00512 CYP17A; steroid 17alpha-monooxygenase / 17alpha-hydroxyprogesterone deacetylase [EC:1.14.14.19 1.14.14.32] K01131 STS; steryl-sulfatase [EC:3.1.6.2] K01015 SULT2B1; alcohol sulfotransferase [EC:2.8.2.2] K00513 CYP21A; steroid 21-monooxygenase [EC:1.14.14.16] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K00070 HSD3B; 3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1] K12343 SRD5A1; ...
O Magma Crawler é provavelmente uma forma de vida produzida artificialmente. A sua agressividade puramente irracional comparada à óbvia estratégia de desenvolvimento do Magma Crawler leva à única conclusão, que eles são uma arma biológica muito difícil de controlar. É correto presumir que eles têm origem nas baias de reprodução do que os gnomos chamam de "aqueles embaixo". Se esse for o caso, eles foram criados para guerra e destruição. Eles foram provavelmente criados para causar o máximo de danos aos ambientes subterrâneos. Depois que um Magma Crawler é solto, eles são geralmente abandonados. Isso explica porque espécies errantes podem ser encontradas em quase todos os lugares subterrâneos, geralmente no fim de um caminho de destruição. Como até agora só foram encontrados Magma Crawlers machos, supõe-se que as criaturas fêmeas são retidas somente para reprodução e também para prevenir que a raça se espalhe excessivamente. Devido a longevidade dos Magma ...
1 a Mm ,avV 4k aw .A. .VOLUME XXVI. COLUMBUS, OHIO, WEDNESDAY, MARCH 25, ;:lfl.W. NUMBER 52 (O)i0.StflteonriiaL M sttsububb DAILr. TRI-WEEKLY AND WEEKLY Wt BOHOUIiBn oo. WM- NCIIOIILEh. Kditor. . Tirmi Uvtriably ii ailvanee. tUuT-- MOO paryset. j Iba Carat, pifMk. ... WJi eU Thi K.IXL1 , tw porjoot Wiutt 100 aibKllnwIotN 1 M " TKHMH OF ADVKftT1-lNG BY TUB BQ0AM. fna urns na km aacuss.) Of anly..lie 00; oMiquntb,..l Oot 9 months 12 00 ; ou " I wasU.. . 1 00 Oua " 0 mnnlbi 10 00; uM " 1 k,. 1 Ms ns " Smontli I 00 ; oat " I -Hys 100 On Imoothi SaO;ae M IdiTi..., 76 Una 1 mubUi 4 to om " 1 lassrttM 10 ra-.pteyaq s-lTrUsa-aau bl( won tfcu akova ram. -wtissmsota. ImM mad pv& le tee eolaeia t al Noticas, timsMt (A r4Mry ralss. All doUcm required to be pubbshsd by M, Ugl rates. Iforilsrtd on ths la-Ms iclasWelj atta Ik tnt wtfc. CO r sent, mors thm ths ahov ntfi ; but mil mod will tpjiNM- in tUa Tri-Waskiy wlthoat chanra. HutioMw Osrfs, set eaiof Bve Uaea, sat yeas, la ad-, par Una ; aataida ...
I am using MAGMA to do QR factorization on multiple GPUs. the problem I am facing is that the time it took to factorize on 4 gpus is the same as the time to factorize on 1 gpu. I am using a systme with 4 Tesla gpus. any hints about what I may be doing ...
Free Online Library: Magma and UMC Complete 65-nm Library Characterization Effort. by Business Wire; Business, international Semiconductor industry
George R. McCormick, Michael J. Le Bas; Phlogopite crystallization in carbonatitic magmas from Uganda. The Canadian Mineralogist ; 34 (2): 469-478. doi: Download citation file:. ...
85736-43-2 - Amines, N-C12-18-alkylhexamethylenedi-, acetates - Searchable synonyms, formulas, resource links, and other chemical information.
garsejades precisessen esbardissesses aixaragallà gallofejàssiu coacerven acugulà acensaran aulari sobrealimento deslliguéssiu cercaran desclassaríem ...
Supereruptions violently transfer huge amounts (100 s-1000 s km3) of magma to the surface in a matter of days and testify to the existence of giant pools of magma at depth. The longevity of these giant magma bodies is of significant scientific and societal interest. Radiometric data on whole rocks, glasses, feldspar and zircon crystals have been used to suggest that the Bishop Tuff giant magma body, which erupted ∼760,000 years ago and created the Long Valley caldera (California), was long-lived (|100,000 years) and evolved rather slowly. In this work, we present four lines of evidence to constrain the timescales of crystallization of the Bishop magma body: (1) quartz residence times based on diffusional relaxation of Ti profiles, (2) quartz residence times based on the kinetics of faceting of melt inclusions, (3) quartz and feldspar crystallization times derived using quartz+feldspar crystal size distributions, and (4) timescales of cooling and crystallization based on thermodynamic and heat flow
Over the last forty years, research has revealed the importance of magma mixing as a trigger for volcanic eruptions, as well as its role in creating the diversity of magma compositions in arcs. Sensitive isotopic and microchemical techniques can reveal subtle evidence of magma mixing in igneous rocks, but more robust statistical techniques for bulk chemical data can help evaluate complex mixing relationships. Polytopic vector analysis (PVA) is a multivariate technique that can be used to evaluate suites of samples that are produced by mixing of two or more magma batches. The Papagayo Tuff of the Miocene-Pleistocene Bagaces Formation in northern Costa Rica is associated with a segment of the Central American Volcanic Arc. While this segment of the arc is located on oceanic plateau, recent (<8 Ma) ignimbrites bear the chemical signatures of upper continental crust, marking the transition from oceanic to continental crust. The Papagayo Tuff contains banded pumice fragments consistent with one or more
3UGL: Structural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cdelta
Sharma, P. C. ; Gupta, P. K. (1987) Colchicine induced autotetraploidy in chickpea (Cicer arietinum L.) Journal of Cytology and Genetics, 22 . pp. 58-66. ISSN 0095-4527 Full text not available from this repository. ...
Lamani, M. and Prabhu, K. R. (2012), NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of Propiophenones. Chem. Eur. J., 18: 14638-14642. doi: 10.1002/chem.201202703 ...
Este item pode ser comercializado pelo Mercado. Faz parte do Paladin Set e Magma Set. Esse item também pode ser obtido em concursos feitos pelos Promoteds e Supporteds Fansites ...
(KudoZ) Spanish to English translation of Magma fibrótica retroperitoneal: retroperitoneal fibrotic mass [Medical (general) (Medical)].
Contact metamorphism is the name given to the changes that take place when magma is injected into the surrounding solid rock (country rock). The changes that occur are greatest wherever the magma comes into contact with the rock because the temperatures are highest at this boundary and decrease with distance from it. Around the igneous rock that forms from the cooling magma is a metamorphosed zone called a contact metamorphism aureole. Aureoles may show all degrees of metamorphism from the contact area to unmetamorphosed (unchanged) country rock some distance away. The formation of important ore minerals may occur by the process of metasomatism at or near the contact zone.. When a rock is contact altered by an igneous intrusion it very frequently becomes more indurated, and more coarsely crystalline. Many altered rocks of this type were formerly called hornstones, and the term hornfels is often used by geologists to signify those fine grained, compact, non-foliated products of contact ...
Free flashcards to help memorize facts about phm 315 ch 5. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.
Animators : David Jousselin, Laurie Reisberg Permanent investigators : Pierre Barbey, [Pierre Bouilhol], [Camille Cartier], Françoise (...)
The device boasts 2,000 Mbps data transfer rates and attaches to the MacBook Pro via an ExpressCard/34 connection and PCI Express cable. This allows the MacBook Pro to access higher-end video cards than the one that currently ships with it. Magmas unit accommodates both 6.6″ half-length cards as well as 12.283″ full-length cards, the units selling for US$730 and US$750, respectively. According to MacNN, Magma has stated that the company will support "double-wide" GPU cards in a future generation of the ExpressBox1 to be released later this year ...
Mineral Complexities as Evidence for Open-system Processes in Formation of Intermediate Magmas of the Mount Baker Volcanic Field, Northern Cascade Arc, Ricardo D. (Ricardo Daniel) Escobar-Burciaga. ...
Viewing this board: Raymondviller, agathan, realmey, hizzyairtel(m), eazboi143, abdulbaba200(m), geloorrrrdd(m), alkalidauda1, LadunaI(m), Splendid007, Chuksgeo, RichardKajola(m), Tolarneey, razmub(m), kinglover(m), Modelling(f), jameslojohn(m), bolkay47(m), Soji123(m), 4rty(f), Marioabell, Francizgold, Luizd(m), vickobon(m), DOCKY2020, DAVIES27(m), SwayG, Tmex(m), jerryaji(m), Iyosy, repent4christ, arowz56(m), Emokatic, Getrich47(m), lato2(m), DabLord, Magma012, samkef(m), 247TechBlog(m), DeeMarh(f), rovher(m), anytexy, lummexD(m), sammie92, GeoSilYe(f), Kennydave12(m), cooltony09, YomiTee123, Hasmos(m), abujub(m), Adebunmiemmy(m), Mrphilia and 97 guest(s). (Go Up) ...
The present study demonstrates that all three pathways for urea production, argininolysis, uricolysis and the OUC, are expressed during early development of C. gariepinus. Furthermore, the present finding (Fig.2) that urea accumulates in C. gariepinus larvae also suggests that the relatively high rates of urea excretion observed previously (Terjesen et al., 1997) represent metabolically produced urea. When the excretion data of Terjesen et al. (Terjesen et al., 1997) are employed, it can be estimated that urea accumulation accounts for less than 10% of total urea production (urea-N accumulation + excretion). Nevertheless, urea-N concentrations in fed C. gariepinus larvae are higher than in adult C. gariepinus tissues (Fig.2B), and two- to 10-fold higher than in rainbow trout and Atlantic cod larvae at first-feeding (Wright et al., 1995; Chadwick and Wright, 1999).. This is the first study to report expression of the uricolytic enzymes in early life stages of a teleost. Recently, Vigetti et al. ...
Magnetic Resonance Materials in Physics, Biology and Medicine Editor-in-Chief: David Norris MAGMA is the Official Journal of the European Society for MagneticResonance in Medicine and Biology (ESMRMB). Join ESMRMB now and get free access to MAGMA! MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. The subject areas covered by MAGMA include advances in materials, hardware and software in magnetic resonance technology; new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine; study of animal models and intact cells and reports of clinical trials on humans and clinical validation of magnetic resonance protocols ...
Members of the Australian Workers Union have set up a protest outside the Longford gas plant in Victoria because of changes to the maintenance contracts for hundreds of workers in the oil and gas industry. UGL holds the maintenance contract for Essos onshore facilities and offshore platforms but about 200 workers were told they had to sign up with UGL subsidiary MTCT Services at between 15% and 30% lower wages or lose their jobs. Likening the dispute to the Carlton and United Breweries struggle last year, workers say they will stay until they are offered a better pay deal.
Magma Coleus is from the Giant Exhibition series, a reselected Victorian series. Magma has pink to burgundy leaves, neatly pinked and edged in pure white.
Green Magma Organic USA 11 oz PowderProduct DescriptionPowdered Barley Grass Juice Dietary Supplement Containing Active Enzymes, Antioxidants, Vitamins, Minerals, Amino Acids, Protein, and Chlorophyll. Dr. Hagiwaras GREEN MAGMA is a very nutritious, mildly alkaline powder made from organic young barley grass juice. Young barley grass contains perhaps the most balanced nutrient profile of all green plants with an abundance of vitamins, minerals, antioxidants, amino acids, proteins, active enzymes, and chlorophyll. Daily consumption of Green Magma will help provide your body with essential nutrients that promote the health and vitality of the entire body. After taking Green Magma daily for as little as 1 week, many people have reported feeling a dramatic increase in energy, better looking hair, skin, and nails, and increased regularity all signs of good nutrition. General InformationThe barley grass in Green Magma is grown in some of the worlds most fertile soil on rolling hillsides in Japan and ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
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... : Synopsys, Inc. (Nasdaq: SNPS), a world leader in software and IP used in the design, verification and manufacture of electronic components and systems, has completed its acquisition of Magma® Design Automation Inc. (Nasdaq:LAVA), a provider of chip design software headquartered in San Jose, California. The combination of Synopsys and Magma will enable the company to more rapidly meet the needs of leading-edge …
Volcanic eruptions occur when magma rises from depth to the surface. On land, eruptions are explosive when magma rises fast enough for the dissolved gases to form bubbles within the magma, and then expand violently to erupt a mixture of gas (from the bubbles) and magma (which cools to form solid fragments). A common analogy for this process is the explosive opening of a pressurized bottle of champagne. In contrast, when magma rises slowly, the bubbles can escape freely and magma erupts passively to form lava flows and domes. Underwater, conditions that produce explosive eruptions are probably similar to those that operate in terrestrial environments, as evidenced by the presence of large, submarine, pumice-filled calderas, such as those south of Japan. However, when magma ascent is slow, as is the case at Brimstone Pit, the seawater alters volcanic activity in important ways, particularly because of the capacity of cold seawater to absorb heat. This has the dual effect of causing rapid ...
Her previous experimental work examines the range of magma compositions that can be generated by melting of a carbonated mantle, which provides a means to assist petrological understanding of the highly economic clan of carbonatite-related rocks that are sampled at the Earth surface. Her work on magma mingling and mixing of carbonated magmas challenges the perception that carbonatites are inherently immiscible with silicate magmas, and provides a new perspective with which to approach carbonatite petrogenesis. Recent PhD supervision includes projects on the role of carbonate in diatremic magmatism, magma-sediment-water interaction and associated mineralization, fluid-carbonatite interaction and geochemical and numerical modeling of carbonate-silicate magma mingling ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
My research into crystallization processes in magma chambers has involved investigation of both natural and artificial magmatic systems. Artifical magmas, such as those produced by In-Situ Vitrification allow a unique window into the crystallization processes of magma, as does investigation of crystals forming in the active lava lake of Mount Erebus, Antarctica REFERENCES:. DUNBAR, N.W., CASHMAN, K.V., AND DUPRE, R., 1994. Crystallization processes of anorthoclase phenocrysts in the Mt. Erebus magmatic system: Evidence from crystal composition, crystal size distributions and volatile contents of melt inclusions. In: Volcanological Studies of Mount Erebus. Antarctic Research Series, 66, 129-146. ABSTRACT. DUNBAR, N.W., JACOBS, G.K. AND NANEY, M.T., 1995. Crystallization processes in an artificial magma: variations in crystal shape, growth rate and composition with melt cooling history. Contrib. Mineral. Petrol. 120, 412-425. ABSTRACT. JACOBS, G.K., DUNBAR, N.W., NANEY, M.T., and WILLIAMS, R.T., ...
Volume 35: Physical and Chemical Induced Mutagenesis Study for Identifying Lethality Dose in Chick Pea (|i|Cicer|/i| a|i|rietinum|/i| L.) Var. Co - 4
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Why a new 3v3? TT is a good map for 3s. And just so you guys know they are already making a new 5v5 map. Magma Chamber. MC. But I dont want a new 3s map. I want a new NUMBER like 4vr would be fun. Or a small 2v2v2 3v3v3.Would be better. But a new 3s map I dont need. Sure it would be cool. But than it would spilt the que time way bad. Unless they gave the new map draft mode to if the new 3v3 map. Than people would only play on that map but really all I want is draft or a new map. idc what map what number just a new map. :P. ...
The timescales over which moderate to large bodies of silicic magma are generated and stored are addressed here by studies of two geographically adjacent, successive eruption deposits in the Taupo Volcanic Zone, New Zealand. The earlier, caldera-forming Rotoiti eruption (,100 km3 magma) at Okataina volcano was followed, within months at most, by the Earthquake Flat eruption (10 km3 magma) from nearby Kapenga volcano; both generated non-welded ignimbrite and coeval widespread fall deposits. The Rotoiti and Earthquake Flat deposits are both crystal-rich high-silica rhyolites, with sparse glass-bearing granitoid fragments also occurring in Rotoiti lag breccias generated during caldera collapse. Here we report 238U-230Th disequilibrium data on whole rocks and mineral separates from representative Rotoiti and Earthquake Flat pumices and the co-eruptive Rotoiti granitoid fragments using TIMS and in situ zircon analyses by SIMS. Multiple-grain zircon-controlled crystallisation ages measured by TIMS ...
To determine the association between genetic parameters and traits in chickpea (Cicer arietinum L.) genotypes, a field experiment was conducted with 17 chickpea genotypes using a randomized complete block design with four replications at the Ilam Agricultural and Natural Resources Research Center in the 2004 growing season. Genetic parameters including genetic, environmental and phenotypic variances; coefficients of variation; heritability; genetic advances; correlation coefficients and path coefficients were estimated, and cluster analysis was performed. Heritability values were greater for number of days to 50% maturity (98.43%), number of days to 50% flowering (98.19%), plant height (58.87%), number of secondary branches (45.81%), number of primary branches (42.03%) and number of seeds per plant (35.42%), indicating that these traits are controlled mainly by additive genes and that selection of such traits may be effective for improving seed yield. Number of seeds per plant and 100-seed weight had a
Crystallization of the Lunar Magma Ocean has been empirically modeled and its products inferred from sample observations, but it has never been fully tested experimentally. Presented in this study is the first experimental simulation of lunar differentiation. Two end-member bulk Moon compositions are considered: one enriched in refractory lithophile elements relative to Earth and one with no such enrichment. A two-stage model of magma ocean crystallization based on geophysical models is simulated and features early crystal suspension and equilibrium crystallization followed by fractional crystallization of the residual liquid. An initially entirely molten Moon is assumed. The study presented below focuses on the early cumulates formed by equilibrium crystallization, differences in mantle mineralogy resulting from different bulk Moon compositions and the implications for the source regions for secondary lunar magmatism. There are significant differences in the crystallization sequence between the two
The commonest eruption styles of basaltic volcanoes involve Hawaiian lava fountaining or intermittent Strombolian explosions. We investigate the ways in which magma rise speed at depth, magma volatile content and magma viscosity control which of these eruption styles takes place. We develop a model of the degree of coalescence between gas bubbles in the magma which allows us to simulate the transition between the two extreme styles of activity. We find that magma rise speed is the most important factor causing the transition, with gas content and viscosity also influencing the rise speed at which the transition occurs. Counter to intuitive expectations, a decrease in gas content does not cause a transition from Hawaiian to Strombolian activity, but instead causes a transition to passive effusion of vesicular lava. Rather, a change from Hawaiian to Strombolian style requires a significant reduction in magma rise speed.. ...
PENGARUH PEMBERIAN TOPIKAL EKSTRAK KOLAGEN KULIT IKAN LELE SANGKURIANG (Clarias Gariepinus var) TERHADAP TNF-α DAN JUMLAH FIBROBLAST PADA LUKA BAKAR DERAJAT DUA TIKUS WISTAR
Thermal evolution of cooling magma chambers. E. A. Gorbyliova and V. P. Trubitsyn. Abstract. We calculate the variations of temperature fields in magma chambers and the surrounding material. In a suggested two-dimensional model, a viscous hot melt occupies a horizontal layer (a magma chamber) within a thicker solid layer. The geometry of this system and a temperature gradient in its solid part are initial conditions. Thermal convection starts in the melt and the magma chamber begins to cool, owing to heat loss through conduction in the surrounding solid medium. Melting occurs at liquid/solid interfaces, followed by solidification of the melt. We solve equations of thermal convection and heat conduction in liquid and solid regions, respectively. Numerical solutions are obtained by the single-region method where equations are applied to the whole region and the moving phase boundary results from calculations. The problem so formulated reduces to generalized equations of thermal convection with the ...
Extrusive rock: Extrusive rock, any rock derived from magma (molten silicate material) that was poured out or ejected at Earths surface. By contrast, intrusive rocks are formed from magma
TheInfoList.com - (Igneous) IGNEOUS ROCK (derived from the LATIN Latin word ignis meaning fire), or MAGMATIC ROCK, is one of the three main rock types , the others being sedimentary and metamorphic . IGNEOUS ROCK Igneous rock is formed through the cooling and solidification of magma or lava . The magma can be derived from partial melts of existing rocks in either a planet s mantle or crust
Видеокамера предназначена для преобразования оптического изображения, создаваемого эндоскопом при всех видах эндоскопических исследований и операций, в полный телевизионный сигнал цветного изображения в системе PAL. Камерная головка видеокамеры снабжена объективом с переменным фокусным расстоянием. Видеокамера оснащена встроенным блоком питания, предназначенным для подключения светодиодного осветителя в вариантах его исполнения ...
Textures in an exceptionally preserved effusive rhyolite conduit at Torfajokull, Iceland, indicate that rising magma repeatedly fractured and healed at shallow levels in the conduit (RFH process). Anastomosing tuffisite veins filled by fine-grained juvenile clasts were generated by shear fracture of highly viscous magma in the glass transition interval. Welding of the particulate material during subsequent deformation led to thorough healing of veins, allowing repeated fracture of the same body of magma. We propose that the RFH process is a rechargeable trigger mechanism for hybrid seismicity and show that the time scale of the process and the fractures formed by it are consistent with the repeat time and magnitude of hybrid earthquakes during silicic eruptions. The RFH process may also form the flow banding that is nearly ubiquitous in obsidian.. ...
The researchers geospeedometer is based on millimeter-sized quartz crystals that grew within the magma bodies that produced these giant eruptions. Quartz crystals are typically found in magmas that have a high percentage of silica. This type of magma is very viscous and commonly produces extremely violent eruptions. Mount St. Helens was a recent example.. When the crystals form, they often capture small blobs of molten magma - known as blebs or melt inclusions. Blebs are initially round. While the crystal is floating in hot magma, diffusion causes them to gradually acquire the polygonal shape of the crystal void that they occupy. But this faceting process can be halted if eruption occurs before complete faceting is achieved.. Using advanced 3-D X-ray tomography, the researchers were able to measure the size and shape of the melt inclusions with exquisite precision. In cases where the inclusions had not become completely faceted, the researchers could determine how much time had elapsed since ...
Download disaster, eruption, lava, magma, volcanic, volcano, volcanology icon in .PNG or .ICO format. Icon designed by Milan Kohut found in the icon set ProGlyphs - Science and Medicine
In the previous installment, we said that there were two main sources of volcanism, tectonic driven or hotspot driven. In order to simplify things, we will examine the life cycle of an Arc Volcano, one where the deep source of magma is the re-melting of a subducted continental slab. Some tens of millions of years ago, two continental plates collided and one, usually the "heavier" one, was subducted. A few million years ago, the edge of the slab had reached a depth of at least 50 km where it began to melt, dissolving the minerals into their constituent molecules and forming a glob of magma that began to rise through the semi-crystalline Upper Mantle or Astenosphere.. When it encountered the lower edge of the overlying continental plate, two things happened. The first was that it began to lift the overlying plate, inducing stresses in it that made it fracture. These small and very deep earthquakes as the plate began to fracture, together with the uplift were the first signs of a new area of ...
The Paizo Pathfinder Roleplaying Game rules. This site is an SRD (System Reference Document) for the Paizo Pathfinder Roleplaying Game.
Effects of rhizobium strains isolated from wild chickpeas on the growth and symbiotic performance of chickpeas (Cicer arietinum L.) under salt stress ...
View Notes - volcan_magma from EENS 2040 at Tulane. Volcanoes, Magma, and Volcanic Eruptions EENS 2040 Natural Disasters Tulane University Prof. Stephen A. Nelson Volcanoes, Magma, and Volcanic
Phosphate is the essential macronutrient required for the growth of all organisms. In Saccharomyces cerevisiae, phosphatases are up-regulated, and the level of lysophosphatidic acid (LPA) is drastically decreased under phosphate-starved conditions. The reduction in the LPA level is attributed to PHM8, a gene of unknown function. phm8 \Delta yeast showed a decreased LPA-hydrolyzing activity under phosphate-limiting conditions. Overexpression of PHM8 in yeast resulted in an increase in the LPA phosphatase activity in vivo. In vitro assays of the purified recombinant Phm8p revealed magnesium-dependent LPA phosphatase activity, with maximal activity at pH 6.5. The purified Phm8p did not hydrolyze any lipid phosphates other than LPA. In silico analysis suggest that Phm8p is a soluble protein with no transmembrane domain. Site-directed mutational studies revealed that aspartate residues in a DXDXT motif are important for the catalysis. These findings indicated that LPA plays a direct role in phosphate ...
Magma Nestable 10 Piece Teflon Stainless Steel Cookware - Cobalt Blue price as low as $232 shop stores & buy Marine Electronics and find best deals
SAN FRANCISCO, CALIFORNIA--(Marketwire - Feb. 5, 2013) - Patient Home Monitoring (PHM) (TSX VENTURE:PHM), a company focused on in-home cardiology healthcare services, today has released a Letter to Shareholders from its Chairman of the Board, Michael Dalsin. To view the letter, please visit PHMs investor website at: www.phmhometesting.com/investor/ChairmansLetter2013 In the...
Make no contact with the spilled material. Fully encapsulating, vapor protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources and ground all equipment. Stop leak if you can do it without risk. A vapor suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean non-sparking tools to collect absorbed material ...
Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008 ...
Project Magma has announced a new update and demo of Bungies classic addictive real-time tactical game, Myth II: Soulblighter. The update, version 1.5.1,
Afters months of waiting, I have finally been able to get my act together enough to post the answers to questions you posed to |a href=http://www.science.oregonstate.edu/~kentad/|Dr. Adam Kent|/a|. If you remember back to |a href=http://bigthink.com/ideas/24029|the beginning of the fall|/a|, Dr. Kent and his colleagues published a paper in |em|Nature Geosciences|/em| about the |a href=http://www.nature.com/ngeo/journal/v3/n9/abs/ngeo924.html|nature of magma mixing|/a| and ...
Supervolcanoes, massive eruptions with potential global consequences, appear not to follow the conventional volcano mechanics of internal pressure building until the volcano blows. Instead, a new study finds, such massive magma chambers might erupt when the roof above them cracks or collapses.

Proteaasid - Vikipeedia, vaba entsüklopeediaProteaasid - Vikipeedia, vaba entsüklopeedia

Amidine-lyases Kasutatud 23.10.2016 (inglise) *↑ 11,0 11,1 Craik, C. S. et al., (2011). Proteases as therapeutics. Biochem J., ... 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 Rawlings, N. D., et al., (2011) Asparagine Peptide Lyases: A ...
more infohttps://et.wikipedia.org/wiki/Proteaas

Peptidylamidoglycolate lyase - WikipediaPeptidylamidoglycolate lyase - Wikipedia

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is ... peptidyl-alpha-hydroxyglycine alpha-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase. Katopodis ... In enzymology, a peptidylamidoglycolate lyase (EC 4.3.2.5) is an enzyme that catalyzes the chemical reaction ... peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming). Other names in common use include alpha-hydroxyglycine ...
more infohttps://en.wikipedia.org/wiki/Peptidylamidoglycolate_lyase

Purine imidazole-ring cyclase - WikipediaPurine imidazole-ring cyclase - Wikipedia

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is DNA-4,6- ... 9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming). Chetsanga CJ, ... diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing DNA-adenine-forming). Other names in common use include DNA-4,6-diamino-5- ...
more infohttps://en.wikipedia.org/wiki/Purine_imidazole-ring_cyclase

CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations 
      -...CA2426774A1 - Method for generating a library of oligonucleotides comprising a controlled distribution of mutations -...

102000009575 Amidine-Lyases Human genes 0 description 1 * 108010034488 Amidine-Lyases Proteins 0 description 1 ... 108090000489 Carboxy-Lyases Proteins 0 description 1 * 102000007132 Carboxyl and Carbamoyl Transferases Human genes 0 ... 108090000673 Ammonia-Lyases Proteins 0 description 1 * AVKUERGKIZMTKX-NJBDSQKTSA-N Ampicillin Chemical compound data:image/svg+ ... 108090000453 Intramolecular Lyases Proteins 0 description 1 * 108010084764 Intramolecular Oxidoreductases Proteins 0 ...
more infohttps://patents.google.com/patent/CA2426774A1/en

Serine dehydratase - wikidocSerine dehydratase - wikidoc

Serine dehydratase or L-serine ammonia lyase (SDH) is in the β-family of pyridoxal phosphate-dependent (PLP) enzymes. SDH is ... L-serine hydro-lyase. Enzyme structure. HoloEnzyme: The holoenzyme SDH contains 319 residues, 1 PLP cofactor molecule, and 131 ... The β enzymes are all lyases and catalyze reactions where Cα and Cβ participate. Overall, in the PLP-dependent enzymes, the PLP ...
more infohttp://es.wikidoc.org/index.php/Serine_dehydratase

Argininosuccinate lyase (P04076) - Yeast Metabolome DatabaseArgininosuccinate lyase (P04076) - Yeast Metabolome Database

carbon-nitrogen lyase activity. amidine-lyase activity. catalytic activity. argininosuccinate lyase activity. ...
more infohttp://www.ymdb.ca/proteins/P04076

Argininosuccinate | definition of argininosuccinate by Medical dictionaryArgininosuccinate | definition of argininosuccinate by Medical dictionary

M2 PHARMA-September 21, 2017-FDA Grants Orphan Drug Designation to PhaseRx for PRX-ASL for Treatment of Argininosuccinate Lyase ... Additional galU genes were found adjacent to the gene argH encoding argininosuccinate lyase in the sequenced genomes from ... M2 EQUITYBITES-September 21, 2017-PhaseRx wins US FDAs orphan drug designation for PRX-ASL for argininosuccinate lyase ... FDA Grants Orphan Drug Designation to PhaseRx for PRX-ASL for Treatment of Argininosuccinate Lyase Deficiency ...
more infohttp://medical-dictionary.thefreedictionary.com/argininosuccinate

E367 | definition of E367 by Medical dictionaryE367 | definition of E367 by Medical dictionary

amidine-lyase. *aminopromazine. *antianemic. *antihistamines. *Antispasmodic Drugs. *argininosuccinate lyase. *aspartate ...
more infohttp://medical-dictionary.thefreedictionary.com/E367

US Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.comUS Patent # 4,299,916. Preferential signal production on a surface in immunoassays - Patents.com

... lyases 4.3 Carbon-nitrogen lyases 4.3.1 Ammonia-lyases 4.3.2 Amidine-lyases 4.4 Carbon-sulfur lyases 4.5 Carbon-halide lyases ... Lyases 4.1 Carbon-carbon lyases 4.1.1 Carboxy-lyases 4.1.2 Aldehyde-lyases 4.1.3 Ketoacid-lyases 4.2 Carbon-oxygen lyases 4.2.1 ... Lyases 4.1 Carbon-carbon lyases 4.1.2 Aldehyde lyases 13. aldolyase 4.2.1 Hydro-lyases 1. carbonic anhydrase 5. Isomerase 5.4 ... bonds other than peptide bonds 3.5.1 In linear amides 3.5.2 In cyclic amides 3.5.3 In linear amidines 3.5.4 In cyclic amidines ...
more infohttp://patents.com/us-4299916.html

EC 4 IntroductionEC 4 Introduction

... lyases acting on amides, amidines, etc. (EC 4.3.2), the amine-lyases (EC 4.3.3), and other carbon-nitrogen lyases (EC 4.3.99). ... EC 4. Lyases. Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation. They ... EC 4.2 Carbon-Oxygen Lyases. These enzymes catalyse the breakage of a carbon-oxygen bond. In the case of hydro-lyases (EC 4.2.1 ... EC 4.1 Carbon-Carbon Lyases. This subclass contains the decarboxylases (EC 4.1.1), the aldehyde-lyases catalysing the reversal ...
more infohttp://www.sbcs.qmul.ac.uk/iubmb/enzyme/EC4/intro.html

ENZYME search by enzyme classENZYME search by enzyme class

4. 3. 1.- Ammonia-lyases. 4. 3. 2.- Lyases acting on amides, amidines, etc. 4. 3. 3.- Amine-lyases. 4. 3.99.- Other carbon- ... 4. -. -.- Lyases. 4. 1. -.- Carbon-carbon lyases. 4. 1. 1.- Carboxy-lyases. 4. 1. 2.- Aldehyde-lyases. 4. 1. 3.- Oxo-acid- ... 4. 7. -.- Carbon-phosphorus lyases. 4. 7. 1.- Carbon-phosphorus lyases. 4.99. -.- Other lyases. 4.99. 1.- Other lyases. 5 ... 4. 4. -.- Carbon-sulfur lyases. 4. 4. 1.- Carbon-sulfur lyases. 4. 5. -.- Carbon-halide lyases. 4. 5. 1.- Carbon-halide lyases ...
more infohttps://enzyme.expasy.org/enzyme-byclass.html

AMIDEAST - What does AMIDEAST stand for? The Free DictionaryAMIDEAST - What does AMIDEAST stand for? The Free Dictionary

amidine-lyase. *Amidines. *Amidines. *Amidines. *Amidino. *Amidino. *Amidino. *amidinohydrolases. *Amidinopropane Hydrochloride ...
more infohttps://acronyms.thefreedictionary.com/AMIDEAST

AMIDE - What does AMIDE stand for? The Free DictionaryAMIDE - What does AMIDE stand for? The Free Dictionary

Looking for online definition of AMIDE or what AMIDE stands for? AMIDE is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
more infohttps://acronyms.thefreedictionary.com/AMIDE

Amide anesthetic | Article about amide anesthetic by The Free DictionaryAmide anesthetic | Article about amide anesthetic by The Free Dictionary

Looking for amide anesthetic? Find out information about amide anesthetic. anesthetic a substance that causes anaesthesia a substance that acts selectively on the central nervous system and induces a state of anesthesia.The meaning... Explanation of amide anesthetic
more infohttps://encyclopedia2.thefreedictionary.com/amide+anesthetic

KEGG BRITE: Enzymes - Equus caballus (horse)KEGG BRITE: Enzymes - Equus caballus (horse)

3.5.3 In linear amidines 3.5.4 In cyclic amidines 3.5.5 In nitriles ... 4. Lyases 5. Isomerases 6. Ligases [ BRITE , KEGG2 , KEGG ]. Last updated: March 17, 2018. EC number data are obtained from ...
more infohttp://www.genome.jp/kegg-bin/get_htext?ecb01000+100070281

GTP cyclohydrolase II - WikipediaGTP cyclohydrolase II - Wikipedia

... specifically in cyclic amidines. The systematic name of this enzyme class is GTP 7,8-8,9-dihydrolase (diphosphate-forming). ...
more infohttps://en.wikipedia.org/wiki/GTP_cyclohydrolase_II

Succinyl-diaminopimelate desuccinylase - WikipediaSuccinyl-diaminopimelate desuccinylase - Wikipedia

3.5.4: Cyclic amidines/. Aminohydrolases. *Guanine deaminase. *Adenosine deaminase. *AMP deaminase. *Inosine monophosphate ... EC4 Lyases (list). *EC5 Isomerases (list). *EC6 Ligases (list). *EC7 Translocases (list) ...
more infohttps://en.wikipedia.org/wiki/Succinyl-diaminopimelate_desuccinylase

Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs, European Journal of Medicinal...Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs, European Journal of Medicinal...

Novel steroidal inhibitors of human cytochrome P45017α, (l7α-hydroxylase-Cl7,20-lyase): potential agents for the treatment of ... Unprecedented spiro-annelated sugar isoureas, guanidines and amidines as new families of glycosidase inhibitors ... 17α-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of ... Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17α-hydroxylase-C17,20-lyase ...
more infohttps://www.deepdyve.com/lp/elsevier/synthesis-of-unprecedented-steroidal-spiro-heterocycles-as-potential-ChPTRbSFlA

New Delhi metallo-beta-lactamase 1New Delhi metallo-beta-lactamase 1

354: Cyclic amidines/. Aminohydrolases. *Guanine deaminase. *Adenosine deaminase. *AMP deaminase. *Inosine monophosphate ... EC4 Lyases list. *EC5 Isomerases list. *EC6 Ligases list. *Molecular and Cellular Biology portal ...
more infohttps://www.turkaramamotoru.com/en/new-delhi-metallo-beta-lactamase-1-1053257.html

Aminoacid dehydrogenase-like, N-terminal domain superfamilyAminoacid dehydrogenase-like, N-terminal domain superfamily

carbon-oxygen lyase activity. 0.4756. 1.35. --. INHERITED FROM: hydro-lyase activity ,, 3-dehydroquinate dehydratase activity. ... In cyclic amidines. 0. Informative. Direct. Enzyme Commission (EC). With NAD(+) or NADP(+) as acceptor. 0. Informative. Direct ... lyase activity. 0.2019. 1.116. Moderately Informative. INHERITED FROM: hydro-lyase activity ,, 3-dehydroquinate dehydratase ... carbon-carbon lyase activity. 0.05568. 1.442. Informative. INHERITED FROM: carboxy-lyase activity. ...
more infohttp://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF53223

Galactose-binding domain-like superfamilyGalactose-binding domain-like superfamily

In linear amidines. 0. Highly Informative. Direct. Enzyme Commission (EC). Acting on polysaccharides. 0. Highly Informative. ... Lyases. 1. Least Informative. Inherited. Enzyme Commission (EC). Acting on peptide bonds (peptide hydrolases). 0.0161. Least ... In linear amidines. 0. 1.951. Highly Informative. DIRECT. Enzyme Commission (EC). Acting on polysaccharides. 0. 1.951. Highly ... In linear amidines. 0. Highly Informative. Direct. Enzyme Commission (EC). Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagin. ...
more infohttp://supfam.org/SUPERFAMILY/cgi-bin/scop.cgi?ipid=SSF49785

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules | Cancer ResearchSphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules | Cancer Research

Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human ... by cleavage of S1P catalyzed by S1P lyase or dephosphorylation catalyzed by S1P phosphatase; ref. 1). S1P binds to S1P-specific ... Structural formulas of FTY720 (fingolimod), (S)-FTY720 vinylphosphonate, SKi, BML-258, (R)-FTY720-OMe, ABC294640, and 6 amidine ... For example, Kennedy and colleagues have recently synthesized amidine-based SK1 inhibitors with nanomolar potency that reduce ...
more infohttp://cancerres.aacrjournals.org/content/71/21/6576.full

ECMDB: Ammonium (ECMDB21186) (M2MDB001595)ECMDB: Ammonium (ECMDB21186) (M2MDB001595)

Aspartate ammonia-lyase. General function:. Involved in aspartate ammonia-lyase activity. Specific function:. L-aspartate = ... Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines. Specific function:. ... Ethanolamine ammonia-lyase light chain. General function:. Involved in ethanolamine ammonia-lyase activity. Specific function: ... Putative diaminopropionate ammonia-lyase. General function:. Involved in diaminopropionate ammonia-lyase activity. Specific ...
more infohttp://ecmdb.ca/compounds/ECMDB21186

US Patent Application for TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE IMMUNE RESPONSES TO THERAPEUTIC PROTEINS Patent...US Patent Application for TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE IMMUNE RESPONSES TO THERAPEUTIC PROTEINS Patent...

An amidine linker is prepared by the reaction of an amine group on one component with an imidoester group on the second ... In another embodiment, the enzyme comprises an oxidoreductase, transferase, hydrolase, lyase, isomerase or ligase. In another ... In another embodiment, the enzyme comprises an oxidoreductase, transferase, hydrolase, lyase, isomerase or ligase. In another ... In another embodiment, the enzyme comprises an oxidoreductase, transferase, hydrolase, lyase, isomerase or ligase. In another ...
more infohttps://patents.justia.com/patent/20120276109

Read eBooks online | World Heritage Encyclopedia | GlutaminaseRead eBooks online | World Heritage Encyclopedia | Glutaminase

3.5.4: Cyclic amidines/. Aminohydrolases * Guanine deaminase * Adenosine deaminase * AMP deaminase * Inosine monophosphate ... 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ * Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase ...
more infohttp://worldheritage.org/articles/eng/Glutaminase
  • These enzymes are carbamoyl phosphate synthetase 1 (CPS1), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL), arginase and N-acetylglutamate synthetase. (thefreedictionary.com)
  • Additional galU genes were found adjacent to the gene argH encoding argininosuccinate lyase in the sequenced genomes from isolates a275, 29031, H-ASH/87, and H-ZANE/83, and although the genes were conserved, they were not identical to the galU genes found within the cps locus. (thefreedictionary.com)
  • Serine dehydratase or L -serine ammonia lyase (SDH) is in the β-family of pyridoxal phosphate-dependent (PLP) enzymes. (wikidoc.org)
  • CYP17A1 mutations are associated with steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia type V (AH-V). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (healthmatics.info)
  • This subclass contains the decarboxylases ( EC 4.1.1 ), the aldehyde-lyases catalysing the reversal of an aldol condensation ( EC 4.1.2 ), and the oxo-acid-lyases, catalysing the cleavage of a 3-hydroxy acid ( EC 4.1.3 ), or the reverse reactions. (qmul.ac.uk)
  • In enzymology, a peptidylamidoglycolate lyase (EC 4.3.2.5) is an enzyme that catalyzes the chemical reaction peptidylamidoglycolate ⇌ {\displaystyle \rightleftharpoons } peptidyl amide + glyoxylate Hence, this enzyme has one substrate, peptidylamidoglycolate, and two products, peptidyl amide and glyoxylate. (wikipedia.org)
  • Abiraterone acetate [17-(3-pyridyl)-5,16-androstadien-33-acetate] is a steroid compound which inhibits selectively and efficiently the enzyme 17-ohydroxylase-C17- 20-lyase, which catalyzes the conversion of dehydroepiandrosterone and androstenedione to testosterone. (google.com)
  • Encoded by human CYP17A1 Gene (Cytochrome P450 Family), 508-aa 57-kDa Cytochrome P450 XVIIA1 is a cAMP-regulated endoplasmic reticulum P450 heme-thiolate monooxygenase with 17alpha-hydroxylase and 17,20-lyase activity and a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. (healthmatics.info)
  • Other names in common use include alpha-hydroxyglycine amidating dealkylase, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase. (wikipedia.org)
  • Other names in common use include DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing), DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing, and DNA-adenine-forming). (wikipedia.org)