Amides. Medical search

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.

Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.

Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.

Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.

Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.

Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.

The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.

Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.

A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.

The rate dynamics in chemical or physical systems.

The characteristic three-dimensional shape of a molecule.

A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

The process of cleaving a chemical compound by the addition of a molecule of water.

Peptides composed of between two and twelve amino acids.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).

A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Peptides composed of two amino acid units.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.

BENZOIC ACID amides.

A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.

Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.

Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

The addition of an organic acid radical into a molecule.

AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.

A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

A family of hexahydropyridines.

A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.

Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.

Enzymes that catalyze the transfer of nitrogenous groups, primarily amino groups, from a donor, generally an amino acid, to an acceptor, usually a 2-oxoacid. EC 2.6.

GLYCEROL esterified with FATTY ACIDS.

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)

Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.

The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.

A group of 16-carbon fatty acids that contain no double bonds.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Organic compounds containing the radical -CSNH2.

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

The NADP-specific glutamate dehydrogenase of Neurospora crassa was digested with trypsin, and peptides accounting for 441 out of the 452 residues of the polypeptide chain were isolated and substantially sequenced. Additional experimental detail has been deposited as Supplementary Publication SUP 50052 (11 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem J. (1975) 145, 5. (+info)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use. (+info)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Peptic and chymotryptic peptides were isolated form the NADP-specific glutamate dehydrogenase of Neurospora crassa and substantially sequenced. Out of 452 residues in the polypeptide chain, 265 were recovered in the peptic and 427 in the chymotryptic peptides. Together with the tryptic peptides [Wootton, J. C., Taylor, J. G., Jackson, A. A., Chambers, G. K. & Fincham, J. R. S. (1975) Biochem. J. 149, 749-755], these establish the complete sequence of the chain, including the acid and amide assignments, except for seven places where overlaps are inadequate. These remaining alignments are deduced from information on the CNBr fragments obtained in another laboratory [Blumenthal, K. M., Moon, K. & Smith, E. L. (1975), J. Biol. Chem. 250, 3644-3654]. Further information has been deposited as Supplementary Publication SUP 50054 (17 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem. J. (1975) 145, 5. (+info)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

An extensive loss of a selected population of neurons in Alzheimer's disease is closely related to the formation of paired helical filaments (PHFs). The most striking characteristic of PHFs upon Western blotting is their smearing. According to a previously described protocol (Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Titani, K., and Ihara, Y. (1993) Neuron 10, 1151-1160), smeared tau was purified, and its peptide map was compared with that of soluble (normal) tau. A CNBr fragment from soluble tau (CN5; residues 251-419 according to the 441-residue isoform) containing the microtubule-binding domain migrated at 15 and 18 kDa on SDS-polyacrylamide gel electrophoresis, whereas that from smeared tau exhibited two larger, unusually broad bands at approximately 30 and approximately 45 kDa, presumably representing dimers and trimers of CN5. In the peptide map of smeared tau-derived CN5, distinct peaks eluting at unusual locations were noted. Amino acid sequence and mass spectrometric analyses revealed that these distinct peptides bear isoaspartate at Asn-381 and Asp-387. Because no unusual peptides other than aspartyl or isoaspartyl peptide were found in the digests of smeared tau-derived CN5, it is likely that site-specific deamidation and isoaspartate formation are involved in its dimerization and trimerization and thus in PHF formation in vivo. (+info)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing 100 microM GTPgammaS. 4. Pretreatment of CPAE cells with the Clostridium C2IN-C3 fusion toxin, which inactivates Rho by ADP ribosylation, significantly impaired the activation of ICl,swell in response to the HTS. The current density at +100 mV was 49 +/- 13 pA pF-1 (n = 17) in pretreated cells compared with 172 +/- 17 pA pF-1 (n = 21) in control cells. 5. The volume-independent activation of ICl,swell by intracellular perfusion with GTPgammaS was also impaired in C2IN-C3-pretreated cells (31 +/- 7 pA pF-1, n = 11) compared with non-treated cells (132 +/- 21 pA pF-1, n = 15). 6. Activation of ICl,swell was pertussis toxin (PTX) insensitive. 7. Y-27632, a blocker of Rho kinase, inhibited ICl,swell and delayed its activation. 8. Inhibition of Rho and of Rho kinase by the above-described treatments did not affect the extent of cell swelling in response to HTS. 9. These experiments provide strong evidence that the Rho-Rho kinase pathway is involved in the VRAC activation cascade. (+info)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

The role of a Rho-associated coiled-coil forming kinase in migration of neutrophils has been investigated. Rho-associated coiled-coil forming kinase I was expressed in human neutrophils. Chemotactic peptide led to a Rho-associated coiled-coil forming kinase-dependent increase in phosphorylation of myosin light chain. This was determined with the help of an antibody directed against serine 19-phosphorylated myosin light chain and an inhibitor of Rho-associated coiled-coil forming kinase (Y-27632). Y-27632 suppressed myosin light chain phosphorylation and chemotactic peptide-induced development of cell polarity and locomotion with similar potency (ED50 0.5-1.1 microM). The data strongly suggest that a Rho-associated coiled-coil forming kinase isoform, activated in human neutrophils exposed to chemotactic peptide, is important for motile functions of these cells. (+info)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity. (+info)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

BACKGROUND: Ropivacaine, 0.2%, is a new local anesthetic approved for epidural analgesia. The addition of 4 microg/ml fentanyl improves analgesia from epidural ropivacaine. Use of a lower concentration of ropivacaine-fentanyl may further improve analgesia or decrease side effects. METHODS: Thirty patients undergoing lower abdominal surgery were randomized in a double-blinded manner to receive one of three solutions: 0.2% ropivacaine-4 microg fentanyl 0.1% ropivacaine-2 microg fentanyl, or 0.05% ropivacaine-1 microg fentanyl for patient-controlled epidural analgesia after standardized combined epidural and general anesthesia. Patient-controlled epidural analgesia settings and adjustments for the three solutions were standardized to deliver equivalent drug doses. Pain scores (rest, cough, and ambulation), side effects (nausea, pruritus, sedation, motor block, hypotension, and orthostasis), and patient-controlled epidural analgesia consumption were measured for 48 h. RESULTS: All three solutions produced equivalent analgesia. Motor block was significantly more common (30 vs. 0%) and more intense with the 0.2% ropivacaine-4 microg fentanyl solution. Other side effects were equivalent between solutions and mild in severity. A significantly smaller volume of 0.2% ropivacaine-4 microg fentanyl solution was used, whereas the 0.1% ropivacaine-2 microg fentanyl group used a significantly greater amount of ropivacaine and fentanyl. CONCLUSIONS: Lesser concentrations of ropivacaine and fentanyl provide comparable analgesia with less motor block despite the use of similar amounts of ropivacaine and fentanyl. This finding suggests that concentration of local anesthetic solution at low doses is a primary determinant of motor block with patient-controlled epidural analgesia after lower abdominal surgery. (+info)

Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and ... The alkali metal amides, MNH2 (M = Li, Na, K) are commercially available. Sodium amide (also known as sodamide) is synthesized ... Metal amides (systematic name metal azanides) are a class of coordination compounds composed of a metal center with amide ... Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by ...

https://en.wikipedia.org/wiki/Metal_amides

... amide ligands and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis( ... amide. In line with the general method, bis(trimethylsilyl)amides of transition metals are prepared by a reaction between the ... Cage Complexes of N-Heterocyclic Amide and Bis(trimethylsilyl)amide Ligands: Synthesis, Structure, and Magnetic Properties". ... Metal bis(trimethylsilyl)amides are strong bases. They are corrosive, and are incompatible with many chlorinated solvents. ...

https://en.wikipedia.org/wiki/Metal_bis(trimethylsilyl)amides

In primary and secondary amides, the presence of N-H dipoles allows amides to function as H-bond donors as well. Thus amides ... Cyclic amides are called lactams; they are necessarily secondary or tertiary amides. Amides are prevalent throughout the ... "amide". The American Heritage Dictionary of the English Language (5th ed.). HarperCollins. "amide - Definition of amide in ... Primary amides (RC(O)NH2) are more amenable to this reaction. Amidogen Amino radical Amidicity Metal amides "Amide definition ...

https://en.wikipedia.org/wiki/Amide

The dansyl amide moiety is also called a dansyl group, and it can be introduced into amino acids or other amines in a reaction ... Dansyl amide is a fluorescent dye that forms in a reaction between dansyl chloride and ammonia. It is the simplest ...

https://en.wikipedia.org/wiki/Dansyl_amide

... is an inorganic compound with the chemical formula KNH2. Like other alkali metal amides, it is a white solid ... Potassium amide is produced by the reaction of ammonia with potassium. The reaction typically requires a catalyst. ... O. Glemser, H. Sauer (1963). "Silver Amide". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry, 2nd Ed. Vol. 1. ... Takaki, Katherine S. (2001). "Potassium Amide". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rp193. ...

https://en.wikipedia.org/wiki/Potassium_amide

H2 The conjugate bases of amines are known as amides. Thus, a lithium amide may also refer to any compound in the class of the ... Lithium amide or lithium azanide is an inorganic compound with the chemical formula LiNH2. It is a white solid with a ... The cyclic oligomers form when the nitrogen of the amide forms a sigma bond to a lithium while the nitrogen lone pair binds to ... Sodium amide Butyllithium David, William I. F.; Jones, Martin O.; Gregory, Duncan H.; Jewell, Catherine M.; Johnson, Simon R.; ...

https://en.wikipedia.org/wiki/Lithium_amide

As such, sodium amide is to be stored in a tightly closed container, under an atmosphere of an inert gas. Sodium amide samples ... Sodium amide can be prepared by the reaction of sodium with ammonia gas, but it is usually prepared by the reaction in liquid ... Sodium amide is mainly used as a strong base in organic chemistry, often in liquid ammonia solution. It is the reagent of ... Sodium amide induces the loss of two equivalents of hydrogen bromide from a vicinal dibromoalkane to give a carbon-carbon ...

https://en.wikipedia.org/wiki/Sodium_amide

... in such structures a 9-atom amide ring occurs between the amide side chain of the pentapeptide's asparagine and the main chain ... Amide Rings are small motifs in proteins and polypeptides. They consist of 9-atom or 11-atom rings formed by two CO...HN ... An amide ring is employed in the specificity of the adaptor protein GRB2 for a particular asparagine within proteins it binds. ... An 11-atom amide ring, involving a glutamine residue, occurs at the interior of the light chain variable domains of some ...

https://en.wikipedia.org/wiki/Amide_ring

N,N-disubstituted amides can be reduced to aldehydes by using an excess of the amide:[citation needed] R(CO)NRR' + LiAlH4 → ... Amide reduction is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group ... Some amides can be reduced to aldehydes in the Sonn-Müller method. A well known method for amide reduction is hydrosilylation ... Zhou, S.; Junge, K.; Addis, D.; Das, S.; Beller, M. (2009). "A Convenient and General Iron-Catalyzed Reduction of Amides to ...

https://en.wikipedia.org/wiki/Amide_reduction

Fatty acid amides (FAAs) are amides formed from a fatty acid and an amine. In nature, many FAAs have ethanolamine as the amine ... Other fatty acid amides are fatty acid primary amides (FAPAs). They contain the functionality RC(O)NH2). Oleamide is an example ... The signalling is controlled in part by fatty acid amide hydrolases, which convert the amide to the parent fatty acid. One ... Wikimedia Commons has media related to Fatty acid amides. (Commons category link is on Wikidata, Fatty acid amides). ...

https://en.wikipedia.org/wiki/Fatty_acid_amide

... (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD+ oxidoreductase. This ... glutathione amide disulfide + NADH + H+ Glutathione amide reductase is a dimeric flavoprotein (FAD). Vergauwen B, Pauwels F, ... Glutathione+amide+reductase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 1.8.1). ... Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". The Journal of Biological ...

https://en.wikipedia.org/wiki/Glutathione_amide_reductase

cyclic amide or lactam, a cyclic compound with the amide group -C(=O)N- in the ring. metal amide, an ionic compound ("salt") ... "amide". The American Heritage Dictionary of the English Language (5th ed.). HarperCollins. "amide - Definition of amide in ... the "Gold Book") (1997). Online corrected version: (2006-) "amides". doi:10.1351/goldbook.A00266 (Amides). ... 2NR2 The term amide may also refer to amide group, a functional group -C(=O)N= consisting of a carbonyl adjacent to a nitrogen ...

https://en.wikipedia.org/wiki/Amide_(functional_group)

... or PEBA is a thermoplastic elastomer (TPE). It is known under the tradename of PEBAX® (Arkema) and ... Eustache, R.-P. (2005). "Poly(Ether -b-Amide) TPE: Structure, Properties and Applications". In Fakirov, Stoyko (ed.). Handbook ...

https://en.wikipedia.org/wiki/Polyether_block_amide

... (EC 1.11.1.17) is an enzyme with systematic name glutathione amide:hydrogen-peroxide ... Glutathione+amide-dependent+peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". The Journal of Biological ... This enzyme catalyses the following chemical reaction 2 glutathione amide + H2O2 ⇌ {\displaystyle \rightleftharpoons } ...

https://en.wikipedia.org/wiki/Glutathione_amide-dependent_peroxidase

L-proline+amide+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.5.1). ... L-proline amide hydrolase (EC 3.5.1.101, S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase, LaaA, L-amino acid ...

https://en.wikipedia.org/wiki/L-proline_amide_hydrolase

Metal bis(trimethylsilyl)amides Potassium bis(trimethylsilyl)amide, Sigma-Aldrich Tesh, Kris F.; Hanusa, Timothy P.; Huffman, ... Potassium bis(trimethylsilyl)amide (commonly abbreviated as KHMDS, Potassium(K) HexaMethylDiSilazide) is the chemical compound ...

https://en.wikipedia.org/wiki/Potassium_bis(trimethylsilyl)amide

Patricelli MP, Cravatt BF (October 1999). "Fatty acid amide hydrolase competitively degrades bioactive amides and esters ... Fatty acid amide hydrolase or FAAH (EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine ... fatty-acid+amide+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) Proteopedia FAAH entry - ... In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of ...

https://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase

The von Braun amide degradation is the chemical reaction of a monosubstituted amide with phosphorus pentachloride or thionyl ... The secondary amide 1 reacts via its enolized form with phosphorus pentachloride to form the oxonium ion 2. This produces a ... Phillips, B.A.; Fodor, G.; Gal, J.; Letourneau, F.; Ryan, J.J. (1973). "Mechanism of the von Braun amide degradations with ...

https://en.wikipedia.org/wiki/Von_Braun_amide_degradation

... amides Watson, B. T.; Lebel, H. "Sodium bis(trimethylsilyl)amide" in Encyclopedia of Reagents for Organic Synthesis (Ed: L. ... Sodium bis(trimethylsilyl)amide is the organosilicon compound with the formula NaN(Si(CH3)3)2. This species, usually called ... amide". Organometallics. 16 (23): 5108-5112. doi:10.1021/om970444c. Sergey A. Kozmin, Shuwen He, and Viresh H. Rawal. " ...

https://en.wikipedia.org/wiki/Sodium_bis(trimethylsilyl)amide

... amides. MXn + n Li(HMDS) → M(HMDS)n + n LiX where X = Cl, Br, I and sometimes F Metal bis(trimethylsilyl)amide complexes are ... Lithium bis(trimethylsilyl)amide is a lithiated organosilicon compound with the formula LiN(Si(CH3)3)2. It is commonly ... S(N(Si(CH3)3)2)2 is prepared by the reaction of lithium bis(trimethylsilyl)amide and sulfur dichloride (SCl2). 2 LiN(Si(CH3)3)2 ... Lithium amide Lithium diisopropylamide Lithium tetramethylpiperidide Amonoo-Neizer, E. H.; Shaw, R. A.; Skovlin, D. O.; Smith, ...

https://en.wikipedia.org/wiki/Lithium_bis(trimethylsilyl)amide

... (NAAA) EC 3.5.1.- is a member of the choloylglycine hydrolase family, a subset of the N ... NAAA cleaves C-N non-peptide bonds in linear amides, particularly ethanolamides. Its mechanism is quite similar to that of AC, ... While NAAA operates much like fatty acid amide hydrolase (HUGO gene symbol: FAAH), the two enzymes are not homologous. On the ... and functional similarity to fatty acid amide hydrolase (FAAH) allow it to be studied extensively. The overall enzyme mechanism ...

https://en.wikipedia.org/wiki/N-acylethanolamine_acid_amide_hydrolase

... (3-Pentyllysergamide, LSP) is an analogue of LSD originally researched by David E. Nichols and ... Lysergic acid 2-butyl amide Methylisopropyllysergamide Nichols DE (2001). "LSD and Its Lysergamide Cousins". The Heffter Review ... "Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes". Journal of Medicinal ...

https://en.wikipedia.org/wiki/Lysergic_acid_3-pentyl_amide

It is a structural isomer of LSD, with the two ethyl groups on the amide nitrogen having been replaced by a single sec-butyl ... Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly ... US patent 2997470, Richard P. Pioch, "LYSERGIC ACID AMIDES", published 1956-03-05, issued 1961-08-22 Oberlender R, Pfaff RC, ... and while lysergic acid 2-butyl amide is more potent than LSD as a 5-HT1A agonist, it is slightly less potent as a 5-HT2A ...

https://en.wikipedia.org/wiki/Lysergic_acid_2-butyl_amide

A qualitative order of electrophilicity is RCHO (aldehydes) > R2CO (ketones) > RCO2R' (esters) > RCONH2 (amides). A variety of ...

https://en.wikipedia.org/wiki/Carbonyl_group

... a nitroso group bonded to the nitrogen of an amide or similar functional group. Specific classes include the N-nitrosamides, N- ...

https://en.wikipedia.org/wiki/N-Nitrosamides

Akiyama, Masayasu; Katoh, Akira; Ogawa, Takuya (1989). "N-hydroxy amides. Part 8. Synthesis and iron(III)-holding properties of ...

https://en.wikipedia.org/wiki/2-Bromoethyl_ether

Amides give thioamides. With 1,4-diketones the reagent forms thiophenes. It is also used to deoxygenate sulfoxides. The use of ...

https://en.wikipedia.org/wiki/Phosphorus_pentasulfide

Linda P, Stener A, Cipiciani A, Savelli G (January-February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic ...

https://en.wikipedia.org/wiki/1P-LSD

It is an amide of nicotinic acid. Foods that contain niacinamide include yeast, meat, milk, and green vegetables. Niacinamide ... The structure of nicotinamide consists of a pyridine ring to which a primary amide group is attached in the meta position. It ... The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided. Nicotinamide ... Schmidberger JW, Hepworth LJ, Green AP, Flitsch SL (2015). "Enzymatic Synthesis of Amides". In Faber K, Fessner W, Turner NJ ( ...

https://en.wikipedia.org/wiki/Nicotinamide

The protein ligands to the iron are the sidechains of the three cysteine (Cys) residues and two mainchain amide nitrogens. The ... Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L. (2015). "Enzymatic Synthesis of Amides". In Faber, Kurt; ... Asano, Y. (2015). "Hydrolysis of Nitriles to Amides". In Faber, Kurt; Fessner, Wolf-Dieter; Turner, Nicholas J. (eds.). ... which performs nitrile hydrolysis without formation of an intermediate primary amide. A sequence in genome of the ...

https://en.wikipedia.org/wiki/Nitrile_hydratase

Local Anesthetics, Amides. Class Summary. The use of a urethral anesthetic in female patients is controversial. The decision to ...

https://emedicine.medscape.com/article/1949728-medication

SEARCH RESULTS for: Amide Local Anesthetic [Drug Class] (2357 results) *Share : JavaScript needed for Sharing tools. Bookmark ...

https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Amide%20Local%20Anesthetic&searchdb=class&page=69&pagesize=20

Nomination Summary for Nomination Summary for Salmonella assay for amides (N82314). Nomination Summary for Salmonella assay for ... amides (N82314). Nominated Substances: Benzamide, 2-Hydroxybenzamide, N-Hydroxybenzamide, 4-Methoxy-3-nitro-N-phenylbenzamide, ...

https://ntp.niehs.nih.gov/go/nm-n82314

Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide

https://www.sigmaaldrich.com/US/en/technical-documents/protocol/analytical-chemistry/small-molecule-hplc/hplc-analysis-of-flavonoids

The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor ... Amide Local Anesthetics No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [ ... The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor ...

https://pubmed.ncbi.nlm.nih.gov/31643241/

The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor ... Other amide local anesthetics have not been implicated in this type of liver injury, but they are rarely given over a period of ... The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor ... The amide local anesthetics are metabolized locally and do not affect the activity of cytochrome P450 enzymes. ...

https://www.ncbi.nlm.nih.gov/books/NBK547905/

... NEXT PREVIOUS. Downloadable transform files: Source .src file, compiled lhasa ...

https://cactus.nci.nih.gov/download/savi_download_transformwise/savi_2020_transform_wise_pages/6038.html

... Tianshun Hu and Chaozhong Li*. *Shanghai ...

https://www.organic-chemistry.org/abstracts/literature/890.shtm

Optimized PM7 data set: MERS=(1,1,1) CHARGE=0 OUTPUT THREADS=1 PM7 GRADIENTS NOTXT EF Sodium amide (NaNH2) (ICSD 14007) h=-29.6 ... Optimized PM6_D3H4 data set: MERS=(1,1,1) CHARGE=0 EF OUTPUT THREADS=1 PM6-D3H4 GRADIENTS Sodium amide (NaNH2) (ICSD 14007) ( ... 337 Sodium amide (NaNH2) (ICSD 14007) (Previous) Sodium acetylide (Na2C2) (ICSD 28066). (Back) Elements: Na 1 N 1 H 2 (Z = 16 ...

http://openmopac.net/PM7_and_PM6-D3H4_accuracy/data_solids/Sodium_amide__NaNH2___ICSD_14007__Jmol.html

PQ-CAD amides 3a-k were prepared by a simple one-step condensation reaction of PQ with a series of CAD chlorides (method A) or ... In the first series of compounds, PQ and various CADs were connected by amide bonds and in the second series by ... acylsemicarbazides and amide 3f presented the highest LP inhibition (83%-89%). The dimethoxy derivative 7d was the most potent ... amides or hydroxamic acids [49,50,51,52]. Benzotriazolides 2 (active amides) and PQ-benzotriazolide 5 (active urea) were ...

https://www.mdpi.com/1420-3049/21/12/1629

Syntheses of Various Amide Derivatives of Norlysergic Acid and Related Compounds. J.Pharm.Soc.Japan 1976 96(5):673-78 ... Syntheses of Various Amide Derivatives of Norlysergic Acid and Related Compounds." J.Pharm.Soc.Japan. 1976;96(5):673-78. ...

https://www.erowid.org/references/refs_view.php?ID=3341&S=Gu_H

PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different ... FAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18??8 nM. ... SA 47 is a selective and potent inhibitor of fatty acid amide hydrolase (FAAH) and carbamate. Learn More ... JNJ 1661010 is a selective and reversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 12nM). Learn More ...

https://www.adooq.com/faah.html

In this paper, three synthetic approaches to α-diazo amides are described, and their scope and limitations are determined. On ... 6 more authors) (2020) Efficient Approaches for the Synthesis of Diverse α-Diazo Amides. Synthesis, 52 (11). pp. 1695-1706. ...

https://eprints.whiterose.ac.uk/155857/

Inhibitors for Soluble Epoxide Hydrolase (SHE) and Fatty Acid Amide Hydrolase (FAAH) Number: 10,858,338. Year: 2020. Patent ... Patent Detail: Inhibitors for Soluble Epoxide Hydrolase (SHE) and Fatty Acid Amide Hydrolase (FAAH). ...

https://tools.niehs.nih.gov/srp/patents/Detail.cfm?PID=906

cis-trans-Amide isomerism of the 3,4-dehydroproline residue, the unpuckered proline ... 4-double bond was found to increase the barrier of the amide rotation presumably due to the repulsive effect between the amide ... cis-trans-Amide isomerism of the 3,4-dehydroproline residue, the unpuckered proline. * Vladimir Kubyshkin. and ... Scheme 2: The relationship between the pKa of the ammonium function in the amino acid and the amide rotational barrier in ...

https://www.beilstein-journals.org/bjoc/articles/12/57

Ester to amide in one step ?. HI to all members,. I try to make amide bond with ester and amine or amino acid but the yield of ... I try to make amide bond with ester and amine or amino acid but the yield of ester is toooooooooooo little so i search for one ... instead of making desterification then acid chloride then amide bond formation,. can any one help me for that item.. thanks ... instead of making desterification then acid chloride then amide bond formation,. can any one help me for that item.. thanks ...

http://www.sciencemadness.org/talk/viewthread.php?tid=14721

Herbicides based on amides, put up in forms or packings for retail sale or as preparations or articles (excl. goods of ... Herbicides based on amides, put up in forms or packings for retail sale or as preparations or articles (excl. goods of ... such products based on phenoxy-phytohormones, triazines, amides, carbamates, dinitroaniline derivatives or derivatives of urea ...

https://www.uktradeinfo.com/commodities/38089315

Structures of amide-water neutral complexes from dipole-bound anion formation Eur. Phys. J. D 20, 449-457 (2002). ...

https://www.epj-conferences.org/articles/epjconf/ref/2017/01/epjconf_spectro2017_03048/epjconf_spectro2017_03048.html

Christoffersen M, Bolvig S, Tüchsen E. Salt effects on the amide hydrogen exchange of bovine pancreatic trypsin inhibitor. ... Salt effects on the amide hydrogen exchange of bovine pancreatic trypsin inhibitor. I: Biochemistry. 1996 ; Bind 35. s. 2309- ... Christoffersen, M., Bolvig, S., & Tüchsen, E. (1996). Salt effects on the amide hydrogen exchange of bovine pancreatic trypsin ... Christoffersen, M, Bolvig, S & Tüchsen, E 1996, Salt effects on the amide hydrogen exchange of bovine pancreatic trypsin ...

https://forskning.ruc.dk/da/publications/salt-effects-on-the-amide-hydrogen-exchange-of-bovine-pancreatic-

Spectral and microscopic study of self-assembly of novel cationic spermine amides of betulinic acid. Bildziukevich U., Kaletová ... Spectral and microscopic study of self-assembly of novel cationic spermine amides of betulinic acid ... Spectral and microscopic study of self-assembly of novel cationic spermine amides of betulinic acid ...

http://www.ueb.cas.cz/cs/content/spectral-and-microscopic-study-self-assembly-novel-cationic-spermine-amides-betulinic-acid

Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides. Anthony G M Barrett, Mark R ... Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides. Dalton Transactions. 2010 Aug 21; ... Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides. / Barrett, Anthony G M; Crimmin, ... Carbodiimide insertion reactions of homoleptic heavier alkaline earth amides and phosphides. In: Dalton Transactions. 2010 ; ...

https://researchportal.bath.ac.uk/en/publications/carbodiimide-insertion-reactions-of-homoleptic-heavier-alkaline-e

Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of amides with ... Amides contain the structural group RCONH2 (where R is any organic radical). In some amides the hydrogen atoms are replaced by ... Most amides are solids at room temperature (exception: formamide). Amides containing five carbon atoms or fewer are soluble in ... Amides and Imides. What are reactive groups?. Reactive groups are categories of chemicals that typically react in similar ways ...

https://cameochemicals.noaa.gov/react/6

The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact ... The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact ... The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact ...

https://gut.bmj.com/content/40/5/597.citation-tools

TRAP-6 amide is a synthetic PAR 1 Antagonist (Thrombin Receptor Activating Peptide). ... TRAP-6 amide is a synthetic PAR 1 Antagonist (Thrombin Receptor Activating Peptide). This peptide fragment irreversibly ...

https://www.biodatacorp.com/trap-6-amide

Cys18]-Atrial Natriuretic Factor (4-18) amide (rat) SKU: SKU-4462 Category: Atrial, Peptides ...

https://www.advancedchemtech.com/product/ala1-par-4-1-6-amide-mouse/

Severity of alcohol dependence is associated with the fatty acid amide hydrolase C385A missense variant. Thursday, September 15 ... One of the primary endocannabinoid neurotransmitters, anandamide, is degraded by fatty acid amide hydrolase, an enzyme with a ...

https://researchfestival.nih.gov/2016/posters/severity-alcohol-dependence-associated-fatty-acid-amide-hydrolase-c385a

Dynamics Of Excess Electronic Charge In Aliphatic Ionic Liquids Containing The Bis(trifluoromethylsulfonyl)amide Anion. ... amide Anion. Together they form a unique fingerprint. ...

https://pure.qub.ac.uk/en/publications/dynamics-of-excess-electronic-charge-in-aliphatic-ionic-liquids-c/fingerprints/?sortBy=alphabetically

Reaktion der Amide mit Formaldehyd. *R. Květoň. Reaktionen von Amiden mit Formaldehyd XII. Verlauf und die Kinetik der ...

http://cccc.uochb.cas.cz/serials/Reaktion-der-Amide-mit-Formaldehyd/

One of the primary endocannabinoid neurotransmitters, anandamide, is degraded by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (FAAH C385A, rs324420) that has been linked to problem drug and alcohol use in humans. (nih.gov)
Based on various investigations, amides like ethoxylated fatty amide, along with various types of ethylene oxides, can inhibit corrosion of carbon steels immersed in hydrochloric solutions. (corrosionpedia.com)
CannaKeys has 312 studies associated with Fatty Acid Amide Hydrolase (FAAH). (cannakeys.com)
The naturally occurring enzyme fatty-acid amide hydrolase (FAAH) was discovered in the late nineties ( B. Cravat 1996 ) and is one of the primary compounds responsible for metabolizing (breaking down) bioactive fatty acid amides such as the endocannabinoid anandamide (AEA) to their corresponding acids, thus terminating the signaling functions of these molecules. (cannakeys.com)
As a result, she presented with significantly higher levels of AEA (and related fatty-acid amides such as palmitoylethanolamide and oleoylethanolamine), presumed responsible for her odd presentations. (cannakeys.com)
They identified a class of compounds called fatty acid amides (FAAs). (nih.gov)

Amides derive chemically from carboxylic acids by the replacement of the -OH portion of the grouping RCOOH with an -NH2 group. (noaa.gov)
The mechanism for the formation of amides from carboxylic acids and amines using dicyclohexylcarbodiimide (DCC). (khanacademy.org)

I try to make amide bond with ester and amine or amino acid but the yield of ester is toooooooooooo little so i search for one sterp conversion instead of making desterification then acid chloride then amide bond formation, can any one help me for that item. (sciencemadness.org)

Polyamides are polymers in which a succession of amide linkages link hold together a molecular chain of high molecular weight. (noaa.gov)
Amide linkages form easily, and are rigid and resistant to hydrolysis, making them very resilient. (corrosionpedia.com)

Insights into enzyme structure and dynamics elucidated by amide H/D exchange mass spectrometry. (nih.gov)
In this report, several applications of H/D exchange MS are presented which demonstrate the unique capability of amide hydrogen/deuterium exchange mass spectrometry for examining dynamic and structural changes associated with enzyme catalysis. (nih.gov)

The simplest form of amides are known to be ammonia derivatives, where one atom of hydrogen has been swapped by an acyl group. (corrosionpedia.com)

Imidazopyridine Amide inhibits ATP synthesis. (nih.gov)

The phosphine complexes of Cu I and Pd 0 engage in distinct catalytic roles without ligand scrambling to render the dual catalysis operative to achieve asymmetric α-allylation of the amide. (elsevier.com)
Saito, A , Kumagai, N & Shibasaki, M 2017, ' Cu/Pd Synergistic Dual Catalysis: Asymmetric α-Allylation of an α-CF 3 Amide ', Angewandte Chemie - International Edition , vol. 56, no. 20, pp. 5551-5555. (elsevier.com)

Although it has been expected that the intramolecular hydrogen bonding (between the tautomeric hydroxy group and the nitrogen atom from the amide group) could stabilize the pure enol form in some solvents, the keto tautomer is also observed. (beilstein-journals.org)
In some amides the hydrogen atoms are replaced by other R groups. (noaa.gov)

Syntheses of Various Amide Derivatives of Norlysergic Acid and Related Compounds. (erowid.org)

Amides react with azo and diazo compounds to generate toxic gases. (noaa.gov)
The stereoselective cyclization of the obtained α-CF 3 -γ,δ-unsaturated amides to give tetrahydropyran and γ-lactone-fused cyclopropane skeletons highlights the synthetic utility of the present catalytic method as a new entry to non-racemic CF 3 -containing compounds. (elsevier.com)

Lidocaine (lye' do kane), bupivacaine (bue piv' a kane) and ropivacaine (roe piv' a kane) are commonly used local anesthetics that are chemically referred to as aminoethylamides or amide local anesthetics. (nih.gov)

The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. (nih.gov)

cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones. (bvsalud.org)
Visible light-induced N-radical 5-exo / 6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones. (bvsalud.org)
An efficient N-centered radical intramolecular cyclization reaction of alkenyl amides induced by visible light was described. (bvsalud.org)
In this process, an alkenyl amide underwent 5-exo/6-endo cyclization to selectively yield two critical alkaloid structures, namely isoindolinones and isoquinolinones. (bvsalud.org)

In clinical trials with the amide local anesthetics, serum aminotransferase and alkaline phosphatase elevations were rarely reported and were generally no more common than with placebo or comparator injections. (nih.gov)

Amides contain the structural group RCONH2 (where R is any organic radical). (noaa.gov)
Amide is a type of compound that is classified under organic groups. (corrosionpedia.com)
The most common form includes organic amides, as well as the more essential types like phosphor amides. (corrosionpedia.com)

Amides containing five carbon atoms or fewer are soluble in water. (noaa.gov)
Take for example carbon steels, which are submerged in acidic solutions with the presence of amide. (corrosionpedia.com)
Herein, we report the strategic merger of Cu I /base-catalyzed enolization of an α-CF 3 amide and Pd 0 -catalyzed allylic alkylation in an enantioselective manner to deliver chiral building blocks bearing a stereogenic carbon center connected to a CF 3 , an amide carbonyl, and a manipulable allylic group. (elsevier.com)

Other less commonly used amide anesthetics include articaine (Septocaine: 2000), mepivacaine (Carbocaine: 1960), and prilocaine (Citanest: 1965). (nih.gov)

The concept for sensing systems using the tautomerism as elementary signaling process has been further developed by synthesizing a ligand containing 4-(phenyldiazenyl)naphthalene-1-ol as a tautomeric block and an amide group as metal capturing antenna. (beilstein-journals.org)

Amides are versatile chemicals that enter into many useful reactions, especially in the fertilizer industry. (noaa.gov)

Despite widespread use for many decades, the local amide anesthetics, when given as single or limited injections or infusions, have not been convincingly linked to instances of clinically apparent liver injury, and liver toxicity is not mentioned in product labels. (nih.gov)
Amide H/D exchange mass spectrometry (H/D exchange MS) is emerging as an efficient technique to study the local and global changes in protein structure and dynamics due to ligand binding, protein activation-inactivation by modification, and protein-protein interactions. (nih.gov)

Herbicides based on amides, put up in forms or packings for retail sale or as preparations or articles (excl. (uktradeinfo.com)

Flammable gases are formed by the reaction of amides with strong reducing agents. (noaa.gov)
Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. (noaa.gov)

As far as heterocyclic amides are concerned, ring enlargement and the replacement of the distal nitrogen invariably led to a more or less complete loss of cytotoxic activity. (medjchem.com)

One of the primary endocannabinoid neurotransmitters, anandamide, is degraded by fatty acid amide hydrolase, an enzyme with a functional genetic polymorphism (FAAH C385A, rs324420) that has been linked to problem drug and alcohol use in humans. (nih.gov)

The amide local anesthetics including lidocaine, bupivacaine and ropivacaine are commonly used for pain control during minor surgery or invasive procedures such as biopsies, small excisions or dental work. (nih.gov)
Lidocaine (lye' do kane), bupivacaine (bue piv' a kane) and ropivacaine (roe piv' a kane) are commonly used local anesthetics that are chemically referred to as aminoethylamides or amide local anesthetics. (nih.gov)
In clinical trials with the amide local anesthetics, serum aminotransferase and alkaline phosphatase elevations were rarely reported and were generally no more common than with placebo or comparator injections. (nih.gov)

Lidocaine is an amide local anesthetic used in 1-2% concentration. (medscape.com)

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Coco amides (8051-30-7). (nih.gov)
Genetic Toxicity Evaluation of Coco Amides in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)

Other less commonly used amide anesthetics include articaine (Septocaine: 2000), mepivacaine (Carbocaine: 1960), and prilocaine (Citanest: 1965). (nih.gov)

They identified a class of compounds called fatty acid amides (FAAs). (nih.gov)

Organisms1

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes23

Disciplines and Occupations2

Information Science2

Health Care1

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

Amides

Amidohydrolases

Amide Synthases

Glucagon-Like Peptides

Polyunsaturated Alkamides

Endocannabinoids

Magnetic Resonance Spectroscopy

Molecular Structure

Deuterium Exchange Measurement

Carbamates

Spectrophotometry, Infrared

Spectroscopy, Fourier Transform Infrared

Hydrogen

Models, Molecular

Cannabinoid Receptor Modulators

Deuterium

Arachidonic Acids

Glucagon-Like Peptide 1

Protein Conformation

Hydrogen Bonding

Structure-Activity Relationship

Stereoisomerism

Amino Acid Sequence

Peptides

Protein Structure, Secondary

Molecular Sequence Data

Monoacylglycerol Lipases

Protons

Nitrogen Isotopes

Nuclear Magnetic Resonance, Biomolecular

Kinetics

Molecular Conformation

Receptor, Cannabinoid, CB1

Peptide Fragments

Esters

Hydrolysis

Oligopeptides

Substrate Specificity

Mass Spectrometry

Receptors, Glucagon

Hydrogen-Ion Concentration

Catalysis

Lanthanoid Series Elements

Glucagon

Models, Chemical

Binding Sites

Dipeptides

Water

Carboxylic Acids

Circular Dichroism

Receptors, Cannabinoid

Thermodynamics

Crystallography, X-Ray

Amines

Deuterium Oxide

Solvents

Chromatography, High Pressure Liquid

Peptoids

Benzamides

Magainins

Spectrum Analysis, Raman

Protein Folding

Solutions

Pyrrolidonecarboxylic Acid

Glutamine

Spectrometry, Mass, Fast Atom Bombardment

Drug Design

Asparagine

Acylation

Ethanolamines

Oleic Acids

Protein Binding

Cyclization

Enzyme Inhibitors

Temperature

Piperidines

Receptor, Cannabinoid, CB2

Cannabinoids

Spectrometry, Mass, Electrospray Ionization

Benzodioxoles