Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.
Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.
Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.
Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.
Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.
Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.
Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.
A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
The rate dynamics in chemical or physical systems.
The characteristic three-dimensional shape of a molecule.
A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The process of cleaving a chemical compound by the addition of a molecule of water.
Peptides composed of between two and twelve amino acids.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Peptides composed of two amino acid units.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
The addition of an organic acid radical into a molecule.
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
A family of hexahydropyridines.
A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.
Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.
Enzymes that catalyze the transfer of nitrogenous groups, primarily amino groups, from a donor, generally an amino acid, to an acceptor, usually a 2-oxoacid. EC 2.6.
GLYCEROL esterified with FATTY ACIDS.
A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.
Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
A group of 16-carbon fatty acids that contain no double bonds.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Organic compounds containing the radical -CSNH2.

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

The NADP-specific glutamate dehydrogenase of Neurospora crassa was digested with trypsin, and peptides accounting for 441 out of the 452 residues of the polypeptide chain were isolated and substantially sequenced. Additional experimental detail has been deposited as Supplementary Publication SUP 50052 (11 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem J. (1975) 145, 5.  (+info)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use.  (+info)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Peptic and chymotryptic peptides were isolated form the NADP-specific glutamate dehydrogenase of Neurospora crassa and substantially sequenced. Out of 452 residues in the polypeptide chain, 265 were recovered in the peptic and 427 in the chymotryptic peptides. Together with the tryptic peptides [Wootton, J. C., Taylor, J. G., Jackson, A. A., Chambers, G. K. & Fincham, J. R. S. (1975) Biochem. J. 149, 749-755], these establish the complete sequence of the chain, including the acid and amide assignments, except for seven places where overlaps are inadequate. These remaining alignments are deduced from information on the CNBr fragments obtained in another laboratory [Blumenthal, K. M., Moon, K. & Smith, E. L. (1975), J. Biol. Chem. 250, 3644-3654]. Further information has been deposited as Supplementary Publication SUP 50054 (17 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem. J. (1975) 145, 5.  (+info)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

An extensive loss of a selected population of neurons in Alzheimer's disease is closely related to the formation of paired helical filaments (PHFs). The most striking characteristic of PHFs upon Western blotting is their smearing. According to a previously described protocol (Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Titani, K., and Ihara, Y. (1993) Neuron 10, 1151-1160), smeared tau was purified, and its peptide map was compared with that of soluble (normal) tau. A CNBr fragment from soluble tau (CN5; residues 251-419 according to the 441-residue isoform) containing the microtubule-binding domain migrated at 15 and 18 kDa on SDS-polyacrylamide gel electrophoresis, whereas that from smeared tau exhibited two larger, unusually broad bands at approximately 30 and approximately 45 kDa, presumably representing dimers and trimers of CN5. In the peptide map of smeared tau-derived CN5, distinct peaks eluting at unusual locations were noted. Amino acid sequence and mass spectrometric analyses revealed that these distinct peptides bear isoaspartate at Asn-381 and Asp-387. Because no unusual peptides other than aspartyl or isoaspartyl peptide were found in the digests of smeared tau-derived CN5, it is likely that site-specific deamidation and isoaspartate formation are involved in its dimerization and trimerization and thus in PHF formation in vivo.  (+info)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing 100 microM GTPgammaS. 4. Pretreatment of CPAE cells with the Clostridium C2IN-C3 fusion toxin, which inactivates Rho by ADP ribosylation, significantly impaired the activation of ICl,swell in response to the HTS. The current density at +100 mV was 49 +/- 13 pA pF-1 (n = 17) in pretreated cells compared with 172 +/- 17 pA pF-1 (n = 21) in control cells. 5. The volume-independent activation of ICl,swell by intracellular perfusion with GTPgammaS was also impaired in C2IN-C3-pretreated cells (31 +/- 7 pA pF-1, n = 11) compared with non-treated cells (132 +/- 21 pA pF-1, n = 15). 6. Activation of ICl,swell was pertussis toxin (PTX) insensitive. 7. Y-27632, a blocker of Rho kinase, inhibited ICl,swell and delayed its activation. 8. Inhibition of Rho and of Rho kinase by the above-described treatments did not affect the extent of cell swelling in response to HTS. 9. These experiments provide strong evidence that the Rho-Rho kinase pathway is involved in the VRAC activation cascade.  (+info)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

The role of a Rho-associated coiled-coil forming kinase in migration of neutrophils has been investigated. Rho-associated coiled-coil forming kinase I was expressed in human neutrophils. Chemotactic peptide led to a Rho-associated coiled-coil forming kinase-dependent increase in phosphorylation of myosin light chain. This was determined with the help of an antibody directed against serine 19-phosphorylated myosin light chain and an inhibitor of Rho-associated coiled-coil forming kinase (Y-27632). Y-27632 suppressed myosin light chain phosphorylation and chemotactic peptide-induced development of cell polarity and locomotion with similar potency (ED50 0.5-1.1 microM). The data strongly suggest that a Rho-associated coiled-coil forming kinase isoform, activated in human neutrophils exposed to chemotactic peptide, is important for motile functions of these cells.  (+info)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity.  (+info)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

BACKGROUND: Ropivacaine, 0.2%, is a new local anesthetic approved for epidural analgesia. The addition of 4 microg/ml fentanyl improves analgesia from epidural ropivacaine. Use of a lower concentration of ropivacaine-fentanyl may further improve analgesia or decrease side effects. METHODS: Thirty patients undergoing lower abdominal surgery were randomized in a double-blinded manner to receive one of three solutions: 0.2% ropivacaine-4 microg fentanyl 0.1% ropivacaine-2 microg fentanyl, or 0.05% ropivacaine-1 microg fentanyl for patient-controlled epidural analgesia after standardized combined epidural and general anesthesia. Patient-controlled epidural analgesia settings and adjustments for the three solutions were standardized to deliver equivalent drug doses. Pain scores (rest, cough, and ambulation), side effects (nausea, pruritus, sedation, motor block, hypotension, and orthostasis), and patient-controlled epidural analgesia consumption were measured for 48 h. RESULTS: All three solutions produced equivalent analgesia. Motor block was significantly more common (30 vs. 0%) and more intense with the 0.2% ropivacaine-4 microg fentanyl solution. Other side effects were equivalent between solutions and mild in severity. A significantly smaller volume of 0.2% ropivacaine-4 microg fentanyl solution was used, whereas the 0.1% ropivacaine-2 microg fentanyl group used a significantly greater amount of ropivacaine and fentanyl. CONCLUSIONS: Lesser concentrations of ropivacaine and fentanyl provide comparable analgesia with less motor block despite the use of similar amounts of ropivacaine and fentanyl. This finding suggests that concentration of local anesthetic solution at low doses is a primary determinant of motor block with patient-controlled epidural analgesia after lower abdominal surgery.  (+info)

This thesis deals with the development and application of new synthetic methodology in organic chemistry.. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. In addition, this methodology is implemented as a key-step in a formal total synthesis of the antibiotic (-)-anisomycin.. In the second part, a new methodology for the synthesis of arylglycines from Weinreb amides is described. In this procedure, a Grignard reagent is added to the iminium ion formed from the Weinreb amide upon treatment with a base. When a chiral amide is used, the nucleophilic addition proceeds with high diastereoselectivity.. Finally, an easy and straightforward synthesis of α-amino amides via a base-mediated rearrangement of modified Weinreb amides into N,O-acetals is presented. Subsequent arylation, alkylation, alkenylation or alkynylation of this intermediate affords the corresponding α-amino ...
The molecular mechanisms conferring high resistance of planar tertiary amide bonds to hydrolysis by most enzymes have remained elusive. To provide a chemical explanation to this unresolved puzzle, UB3LYP calculations were performed on an active site model of Xaa-Pro peptidases. The calculated reaction mechanism demonstrates that biocatalysts capable of tertiary amide bond hydrolysis capitalize on anti nucleophilic attack and protonation of the amide nitrogen, in contrast to the traditional syn displayed by amidases and proteases acting on secondary amide bonds.. ...
The development of versatile and sustainable catalytic strategies for amide bond formation is a major objective for the pharmaceutical sector and the wider chemical industry. Herein, we report a biocatalytic approach to amide synthesis which exploits the diversity of Natures amide bond forming enzymes, N-ac
TY - JOUR. T1 - Crystallization-induced amide bond formation creates a boron-centered spirocyclic system. AU - Levonis, Stephan M. AU - Pappin, Brighid B.. AU - Healy, Peter C.. AU - Kiefel, Milton J.. AU - Simone, Michela. AU - Houston, Todd A.. PY - 2017/6/27. Y1 - 2017/6/27. N2 - The 5-nitrosalicylate ester of 2-acetamidophenylboronic acid (C 15 H 10 BN 2 O 6) is formed under crystallization conditions from the 5-nitrosalicylate ester of 2-aminophenylboronic acid. The boron at the center of this structure exists as a tetrahedral complex produced by a dative bond with the amide carbonyl. The perpendicular shape produces an unusual packing structure including a bifurcated hydrogen bond between the amide hydrogen and carbonyl groups on two neighboring molecules. We propose that this reaction occurs due to increased Lewis acidity of the nitrosalicylate ester of 2-aminophenylboronic acid.. AB - The 5-nitrosalicylate ester of 2-acetamidophenylboronic acid (C 15 H 10 BN 2 O 6) is formed under ...
TY - CONF. T1 - Efficient amide synthesis from aldehydes and amines catalyzed by gold in aqueous medium. AU - Ko, H.M.. AU - Li, G.L.. AU - Kung, K.K.Y.. AU - Wong, Man Kin. PY - 2013. Y1 - 2013. M3 - Conference presentation (not published in journal/proceeding/book). T2 - Symposium on Chemistry Postgraduate Research in Hong Kong. Y2 - 1 January 2013. ER - ...
As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10-18 was determined against three cancer cell lines using the MTT colorimetric assay. The screening revealed that derivatives 16b and 17b exhibited significant cytotoxic activity against the gastric cancer cell line but was not active against a normal cell line, in contrast to doxorubicin, a standard chemotherapeutic drug in clinical use. Interestingly, no hemolytical activity was observed when the toxicity of 16b and 17b was tested against blood cells. The in silico and in vitro mechanistic evaluation indicated the potential of 16b as a lead for the development of novel anticancer agents against gastric cancer cells.
In this project we aim to use a biotechnology-based approach to deliver amides in a more efficient and environmentally sustainable manner. To achieve this, we will explore two complementary methods for producing amides. First, we aim to engineer natures catalysts (enzymes) to create new enzyme variants (mutants) that can couple a wide range of acid and amine substrates. In addition, we plan to combine enzymes with transition metal catalyst to create new integrated catalytic approaches to amides. By combining the best of enzymatic and chemocatalysis, we aim to open new transformations and routes to valuable amides that would be inaccessible using existing methods. Nature has created a number of ways to couple acids and amines to make amide bonds with the most common methods relying on a molecule called ATP to activate the carboxylic acid group facilitating attack of the amine substrate. Such enzymes are called amide ligases and they possess binding sites for both the carboxylic acid and amine ...
A series of 6-endo-(methylthio)-bicyclo[2.2.1]heptane-2-endo-proline amides was synthesized to study the neighboring proline amide participation in electron transfer from thioethers. The thioether with endo-pyrrolidine amide formed a two-center three-electron SO bond after one electron oxidation and the oxidation potential of the thioether was lowered by 530 mV and 330 mV compared to the corresponding exo-pyrrolidine amide and the primary amide analogues, respectively. The thioether with a proline methyl ester showed the oxidation potential of 410 mV higher than that of the pyrrolidine amide. The basis for this surprising result was revealed by an X-ray crystallographic structure study of the diastereomerically pure proline methyl ester which showed amide carbonyl n → methyl ester π* interaction which removes electron density from the neighboring amide which results in less effective neighboring amide participation in thioether oxidation. This accounts for the electrochemical result. A potent ...
Background: Due to this increasing predicament of antibiotic confrontation, the lot of distinct antibiotics available is dwindling and there are only smatterings of new antibiotics in the drug development channel. Therefore, an intense necessitate for new antimicrobial drugs. In current study, we have synthesized the new derivatives with the help of molecular docking studies and investigated antimicrobial activities. Methods: By focusing the enzymes i.e. aminoacyl-tRNA synthetase (AaRS) and tyrosyl-tRNA synthetase, new amides of 2-(3-methylbenzo[b]thiophen-6-yl)-1-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylic acid were synthesized and inhibition by docking study precedence to antimicrobial action. Studies were accomplished on a designed library of amide derivatives with the help of docking softwares i.e. AutoDock Vina 4.2 and Schrodingers maestro package against crystal structure of enzymes (PDB ID: 1wny.PDBQT and1jil.PDBQT). Based upon their dock score, superlative 23 focused amide ...
In this application, Dr Claudio Battilocchio of the Ley group, University of Cambridge, has used Vapourtecs 20 ml Rapid Mixing Reactors to perform an amide synthesis under biphasic flow reaction conditions.
The resins contain 5-10% non cleavable covalently attached ligands, 40 - 45% linker for peptide amide release at low concentrated TFA (5%) and 40 - 45% linker for peptide amide release with 95% TFA. The peptide, liberated by 5% TFA treatment must be seperated from the resin and deprotected with 95% TFA in a follow up step. This resin type is designed for screening of peptide amide libraries by sequential release. ...
The resins contain 5-10% non cleavable covalently attached ligands, 40 - 45% linker for peptide amide release at low concentrated TFA (5%) and 40 - 45% linker for peptide amide release with 95% TFA. The peptide, liberated by 5% TFA treatment must be seperated from the resin and deprotected with 95% TFA in a follow up step. This resin type is designed for screening of peptide amide libraries by sequential release. ...
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Khoo LPY, Corbett AR.Successful resuscitation of an ASA 3 patient following ropivacaine-induced cardiac arrest. Anaesthesia and Intensive Care 34: 804-807, No. 6, Dec 2006 - AustraliaGoogle Scholar ...
Amides are of fundamental interest in many fields of chemistry involving organic synthesis, chemical biology and biochemistry. Here, we report the first catalytic Buchwald-Hartwig coupling of both common esters and amides by highly selective C(acyl)-X (X = O, N) cleavage to rapidly access aryl amide function
The application of ropivacaine before HTV ventilation reduced Src-pTyr418/Src by 37% compared to HTV alone, however, this effect was not statistically significant (p = 0.678). Acta Anaesthesiol Scand. 2005, 49 (7): 913-918. 10.1111/j.1399-6576.2005.00774.x.View ArticlePubMedGoogle ScholarCostantini R, Affaitati G, Fabrizio A, Giamberardino MA: Controlling pain in the post-operative setting. For some experiments, cells were pretreated for 30minutes with the Src kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d] pyrimidine (PP2; 10μM) dissolved in dimethylsulfoxide (DMSO, Sigma-Aldrich) or with DMSO alone as the vehicle control (0.1%) Effect of ropivacaine on endotoxin-induced changes in expression/phosphorylation of Src, ICAM-1 and caveolin-1 in cultured human lung microvascular endothelial cells (HLMVECs) Ropivacaine blocks LPS-induced Src activation and expression in HLMVECs To Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit ...
Hexanamide. Molecular model of the organic compound and amide hexanamide (C6.H13.N.O), also known as capronamide. This chemical reacts with azo and diazo compounds to generate toxic gases. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue) and oxygen (red). Illustration. - Stock Image F016/9786
Provided are: a cyclic amide group-containing polymer having excellent hue, resistance to heat-induced yellowing, and moisture resistance; a cyclic amide acrylate suitable for use as a starting material for the polymer; and a method for producing same. The cyclic amide group-containing polymer is characterized by having a structural unit represented by general formula (1) below. In general formula (1) below, n represents an integer from 1-4, and R1 represents a hydrogen atom, a C1-30 organic group, a metal atom or an ammonium salt.
Beller and co-workers recently published a superb new method for reducing tertiary amides into amines. The reaction is tolerant of a wide range of functionalities including ester, thiomethyl, nitrile, secondary amide, and hydroxyl groups. This post is timely from my perspective because we just had a group meeting discussion about what is new and what is…
An amide bond is a peptide bond. It is formed when the amine group of one amino acid forms a bond with the carboxyl group of another amino acid, resulting in the loss of a single water molecule[1]. The peptide group (-CO-NH-) has partial double-bond characteristics due to the resonance of amides, where the nitrogen atom of the amide group is able to donate its lone pair of electrons to the carbon atom in the carboxyl group and push the electrons from the carbonyl C=O double bond towrds the oxygen atom, which forms an oxygen anion[2]. The resonance double bond increases the stability and decreases the rotation about the peptide bond[3]. ...
The structural study of simple amino amides derived from natural amino acids showed a unique conformational pattern for the aromatic residues, being clearly different from that for the aliphatic derivatives. The results from a detailed NMR analysis, supported by DFT calculations, indicate that the aromatic side chain tends to fold over the amino amide moiety, involving a stabilizing polar N-Hπ interaction. The implications of this folding in the establishing of non-covalent interactions is also discussed ...
Women with sonographic uterine artery flow abnormalities and either PE or IUGR (or both) were randomized to either ACET or non ACET control. Both groups were able to receive standard therapies (in-hospital monitoring, magnesium and anti-hypertensives as appropriate). The first five days of the therapeutic arm (ACET) consisted of a dose-finding trial, where epidural ropivacaine infusions (10ml/hr for 24 hours) of 0•04%, 0•06%, 0•08% and 0•1% and a saline placebo were each administered via tunneled epidural catheters in a randomized, double-blinded, cross-over design over five consecutive days; all three women received all doses. Doppler measurement of flow in the uterine artery was performed at baseline and at the end of each dose period. The ideal dose for an individual was determined to be lowest dose of drug giving maximal effect without side effects; in the second stage of the study, this dose was administered until delivery with the addition of a second placebo day to during this ...
Synonyms for acetic amide in Free Thesaurus. Antonyms for acetic amide. 1 synonym for acetamide: ethanamide. What are synonyms for acetic amide?
Here we report the use of a pillaring strategy for the design and synthesis of three novel amide-functionalized metal-organic frameworks (MOFs), TMUs-22/-23/-24, isoreticular to the recently reported imine-functionalized TMU-6 and TMU-21 MOFs. An extensive study of their CO2 sorption properties and selectivity for CO2 over N2, from single gas sorption isotherms to breakthrough measurements, revealed that not only the incorporation of amide groups but also their accessibility is crucial to obtain enhanced CO2 sorption and CO2/N2 selectivity. Therefore, the MOF with more accessible amide groups (TMU-24) shows a CO2/N2 selectivity value of ca. 10 (as revealed by breakthrough experiments), which is ca. 500% and 700% of the selectivity values observed for the other amide-containing (TMU-22 and TMU-23) and imine-containing (TMU-6 and TMU-21) MOFs ...
The amides are a class of organic compounds which can be regarded as having been derived from either acids or amines. For example, the simple aliphati...
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at the rate of 4 through two catheters inserted at the lateral edges of the sternum will be studied, versus a control group in which normal saline will be infused in the same conditions ...
3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one: a coupling reagent for mediating amide bond formation with little or no racemization; structure in first source
Learn about Naropin (Ropivacaine Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
XBridge BEH Amide columns retain extremely polar compounds, including carbohydrates and sugars. XBridge Amide columns offer you a chemically stable, trifunctionally bonded amide phase that is stable from pH 2 to 11 to enable the separation of polar analytes spanning a wide range of polarity, structural moiety and pKa.
XBridge BEH Amide columns retain extremely polar compounds, including carbohydrates and sugars. XBridge Amide columns offer you a chemically stable, trifunctionally bonded amide phase that is stable from pH 2-11 to enable the separation of polar analytes spanning a wide range of polarity, structural moiety and pKa.
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You may also wish to search for items by Chambers, W. and Chambers. Only one matching reference was found. Hauser, C.R.; Chambers, W.J., The alkylation of tertiary esters of dialkylacetic acids by means of alkali amides synthesis of trialkylacdtic acids, J. Am. Chem. Soc., 1956, 78, 3837-41. [all data] ...
We described the synthesis of carboxamide derivatives designed as novel simplified imatinib analogues and their antiproliferative and anti-inflammatory ..
Thirteen amide-substituted phenyl arsenoxides (-RCONH2, -RSO2NH2) were, per unit arsenic, only 4.5 to 13.5 per cent as toxic as the parent phenyl arsenoxide. Since the treponemicidal activity in vitro was not reduced to the same degree, the ratio of treponemicidal activity: toxicity was 1.9 to 6.1 times more favorable than that of phenyl arsenoxide. The favorable effect of amide groups was confirmed for ten of these compounds by assays of toxicity and therapeutic activity in syphilitic rabbits.. When one or both of the amide hydrogens were substituted (e.g., -SO2N(CH3), -CONH-pyridine), the effect of the entire group shifted toward that of the terminal substituent. In most cases, substitution in the amide therefore caused an increased toxicity, and impaired the favorable effect of the amide group as such. Only in the case of the compounds with terminal hydroxyl acetamido or nitrile groups was the favorable effect of the amide altogether preserved, perhaps because these groups in themselves ...
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The recent study, Sodium Amide market forecasts the business performance of the Sodium Amide market for the forecast period, 2019 to 2026. The study considers the estimated period as the base… Read more » ...
69278-64-4 - Amides, castor-oil, N-(3-(dimethylamino)propyl) - Searchable synonyms, formulas, resource links, and other chemical information.
[117 Pages Report] Check for Discount on Global Polyether Block Amide (PEBA) Market by Manufacturers, Regions, Type and Application, Forecast to 2021 report by Global Info Research. ...
2017-2022 Sodium Amide Report on Global and United States Market, Status and Forecast, by Players, Types and Applications - Radiant Insights
N,N-Diethylhexadecan-1-amide/ACM57303216 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
FREE & DOWNLOADABLE Chemistry revision notes on Production of Amides. Designed by Save My Exams teachers for the CIE (9701) syllabus.
MolCore offers CAS No.128340-47-6, Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle amide for your research needs.Find product specific information including MFCD00133510,128340-47-6 MSDS,Price,Custom Synthesis.
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Sanomenen canviant la terminaci -oic de l cid per amida, si s n la funci principal. Si el seu carboni no es pot incloure dins la cadena principal, es canvia carbox lic per carboxamida i ja inclou el carboni. Si el nitrogen t substituents, sanomenen amb N com a localitzador, igual que a les amines. Exemples ...
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TY - JOUR. T1 - Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure.. AU - McMurray, John J V. AU - Pitt, Bertram. AU - Latini, Roberto. AU - Maggioni, Aldo P.. AU - Solomon, Scott D.. AU - Keefe, Deborah L.. AU - Ford, Jessica. AU - Verma, Anil. AU - Lewsey, Jim. AU - Aliskiren Observation of Heart Failure Treatment (ALOFT) Investigators, Observation of Heart Failure Treatment (ALOFT) Investigators. PY - 2008/5. Y1 - 2008/5. N2 - Loss of negative feedback inhibition of renin release during chronic treatment with an angiotensin-converting enzyme (ACE) inhibitor leads to a compensatory rise in renin secretion and downstream components of the renin-angiotensin-aldosterone (RAAS) cascade. This may overcome ACE inhibition but should be blocked by a direct renin inhibitor. We studied the effects of adding the direct renin inhibitor aliskiren to an ACE inhibitor in patients with heart failure. Patients with New York Heart Association class II to IV heart ...
TY - JOUR. T1 - Electromechanical effects of the direct renin inhibitor (aliskiren) on the pulmonary vein and atrium. AU - Tsai, Chin Feng. AU - Chen, Yao Chang. AU - Lin, Yung Kuo. AU - Chen, Shih Ann. AU - Chen, Yi Jen. PY - 2011/11. Y1 - 2011/11. N2 - Activation of the atrial renin-angiotensin system plays an important role in the pathophysiology of atrial fibrillation (AF). The pulmonary vein (PV) and left atrium (LA) are important trigger and substrate for the genesis of AF. We investigate the effects of a direct renin inhibitor, aliskiren, on the PV and LA arrhythmogenic activity and the underlying electromechanical mechanisms. Conventional microelectrodes were used to record action potentials and contractility in isolated rabbit PVs and LA tissues before and after the administration of aliskiren (0.1, 1, 3 and 10 μM). By the whole-cell patch clamp and indo-1 fluorimetric ratio techniques, ionic currents and intracellular calcium transient were studied in isolated single PV and LA ...
Combinations of the direct renin inhibitor aliskiren with angiotensin receptor blockers (ARBs) or diuretics are effective therapeutic regimens for the treatment of hypertension. A large database of safety information has become available during the past several years with aliskiren in combination trials. Data were pooled from 9 short-term (8-week) and 4 longer-term (26- to 52-week) randomized controlled trials of aliskiren in patients with hypertension. Adverse event (AE) rates were assessed for aliskiren combination therapy compared with component monotherapies. In short-term studies, overall AE rates were similar for patients receiving aliskiren/valsartan or aliskiren/diuretic combinations (32.2%-39.8%) and those receiving the component monotherapies (30.0%-39.6%). In longer-term studies, AE rates with aliskiren/losartan (55.5%) and aliskiren/diuretic (45.0%) combination therapy were similar to those with losartan (53.9%) and diuretic (48.9%) alone. Angioedema and hyperkalemia occurred in ...
Sca-1 and VEGFR-2 positive pro-angiogenic cells (PAC) predict outcome of patients with vascular disease. Activation of the renin-angiotensin-aldosterone system impairs PAC function. The effects of the direct renin inhibitor aliskiren on PAC numbers a
The RAAS is an important pharmacologic target as the system is involved in cardiovascular (CV) and renovascular disease. Ang II is the key component of RAAS. The interven..
TY - JOUR. T1 - A prospective, randomized, blinded study of continuous ropivacaine infusion in the median sternotomy incision following cardiac surgery. AU - Agarwal, Shvetank. AU - Nuttall, Gregory A.. AU - Johnson, Michael E.. AU - Hanson, Andrew C.. AU - Oliver, William C.. PY - 2013/3. Y1 - 2013/3. N2 - Objective: The aim of this prospective, randomized, double-blind, placebo controlled trial was to evaluate the safety and efficacy of continuous ropivacaine infusion of into the sternal wound. Methods: We planned to enroll 200 patients scheduled for various cardiac surgical procedures into the study. Patients, in a double-blind randomized fashion, were given either normal saline or 0.3% ropivacaine through 2 subcutaneous multiport catheters placed on either side of the sternal split at an infusion rate of 4 mL/h for 64 hours. The efficacy outcomes measured were time to extubation of the trachea, intensive care unit and hospital stay duration, pain scores, and narcotic usage. The safety ...
This study is the first to investigate the use of other antihypertensive therapies in combination with HCTZ in a population of obese patients with hypertension who have failed to achieve BP control with HCTZ monotherapy. The addition of aliskiren (150 mg) to treatment with HCTZ (25 mg) for 4 weeks provided a significant additional BP reduction (msSBP/DBP) of 4.4/2.5 mm Hg compared with continuing treatment with HCTZ alone, and increasing the dose of aliskiren to 300 mg for 4 weeks increased the treatment difference to 7.2/4.0 mm Hg. The additional BP reduction provided by combining aliskiren with HCTZ treatment almost doubled the rate of BP control in obese hypertensive patients at 12 weeks (58.4% versus 33.3% with HCTZ alone). The antihypertensive effects of aliskiren were similar to those observed with irbesartan and amlodipine.. Combination with aliskiren suppressed the increase in renin system activity (PRA) caused by HCTZ, whereas irbesartan and amlodipine increased PRA further. Our results ...
TY - JOUR. T1 - Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice. AU - Kang, Young Sun. AU - Lee, Mi Hwa. AU - Song, Hye Kyoung. AU - Hyun, Young Youl. AU - Cha, Jin Joo. AU - Ko, Gang Jee. AU - Kim, Sung Hwan. AU - Lee, Ji Eun. AU - Han, Jee Young. AU - Cha, Dae Ryong. N1 - Funding Information: Acknowledgements. We thank Novartis Pharmaceuticals, Basel, Switzerland for kindly providing aliskiren. This work was supported by a grant from the Brain Korea 21 project and a special grant from Korea University.. PY - 2011/4. Y1 - 2011/4. N2 - Background. Aliskiren is a direct renin inhibitor (DRI) and provides an organ-protective effect in human and animal experiments. However, there is no current evidence of the effect of DRI on insulin resistance and metabolic abnormalities in type 2 diabetic animals.Methods. We investigated the effects and molecular mechanism of aliskiren in db/db mice and cultured mesangial cells (MCs).Results. Aliskiren treatment ...
Among the GTP-binding proteins, Rho is known to function as a molecular switch in various cellular functions. Among the Rho effectors, the cellular function and signal transduction of Rho-kinase have been extensively studied. However, information about its in vivo functions is still limited. With the recent development of a specific Rho-kinase inhibitor such as Y-27632 and fasudil, the understanding of the role of the Rho/Rho-kinase pathway in vitro and in vivo has advanced. However, to date, there have been few studies investigating the role of Rho-kinase in renal disease. Recent studies have shown that Rho-kinase inhibitor significantly attenuated the tubulointerstitial fibrosis in kidney induced by unilateral ureteral obstruction. However, there have been few studies investigating the role of the Rho/Rho-kinase pathway in hypertensive glomerular sclerosis. In this review, we described the role of the Rho/Rho-kinase pathway in the progression of renal glomerulosclerosis in several forms of ...
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation transfer phenomenon that has potential for penumbra identification following stroke. The majority of the literature thus far has focused on generating pH-weighted contrast using magnetization transfer ratio asymmetry analysis instead of quantitative pH mapping. In this study, the widely used asymmetry analysis and a model-based analysis were both assessed on APT data collected from healthy subjects (n = 2) and hyperacute stroke patients (n = 6, median imaging time after onset = 2 hours 59 minutes). It was found that the model-based approach was able to quantify the APT effect with the lowest variation in grey and white matter (≤ 13.8 %) and the smallest average contrast between these two tissue types (3.48 %) in the healthy volunteers. The model-based approach also performed quantitatively better than the other measures in the hyperacute stroke patient APT data, where the quantified APT effect in the
Compared to amines, amides are very weak bases. While the conjugate acid of an amine has a pKa of about 9.5, the conjugate acid of an amide has a pKa around −0.5. Therefore, amides dont have as clearly noticeable acid-base properties in water. This relative lack of basicity is explained by the electron-withdrawing nature of the carbonyl group where the lone pair of electrons on the nitrogen is delocalized by resonance. On the other hand, amides are much stronger bases than carboxylic acids, esters, aldehydes, and ketones (their conjugate acids pKas are between −6 and −10). It is estimated in silico that acetamide is represented by resonance structure A for 62% and by B for 28%.[6] Resonance is largely prevented in the very strained quinuclidone. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N-C dipole. The presence of a C=O dipole and, to a lesser extent a N-C dipole, allows amides to act as H-bond acceptors. In primary and secondary ...
A molecular mechanics (MM) force field-based empirical electrostatic potential map (MM map) for amide-I vibrations is developed with the aim of seeking a quick and reasonable approach to computing local mode parameters and their distributions in solution phase. Using N-methylacetamide (NMA) as a model compound, the instantaneous amide-I normal-mode parameters (transition frequency and dipole) obtained at the level of MM force fields are converted to solution phase values by a four-site potential scheme, but without the need for quantum mechanical frequency computations of solute-solvent clusters as are required in constructing ab initio-based electrostatic potential or field maps. The linear IR line shape of the amide-I mode in NMA obtained from the frequency-time correlation function on the basis of the MM map are found to be comparable to those from the ab initio-based maps. Our results show that the amide-I local mode parameters are largely determined by the solvated peptide structure rather ...
INTRODUCTION: We recently developed and validated in existing trials a novel algorithm (PRE score) to predict long-term drug efficacy based on short-term (month-6) drug-induced changes in multiple risk markers. To show the value of the PRE score for ongoing and planned clinical trials, we here report the predicted long-term cardio-renal efficacy of aliskiren in type 2 diabetes, which was investigated in the ALTITUDE trial, but unknown at the time this study was conducted. METHODS: We established the relation between multiple risk markers and cardio-renal endpoints (as defined in ALTITUDE) using a background database from past clinical trials. The short-term effect of aliskiren on multiple risk markers was taken from the AVOID trial. A PRE score was developed by multivariate Cox analysis in the background population and was then applied to the baseline and month-6 measurements of the aliskiren treatment arm of the AVOID trial to predict cardio-renal risk. The net risk difference at these ...
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Aliskiren is the first direct renin inhibitor approved for the treatment of hypertension. Blood pressure (BP) control in stage 2 hypertension with aliskiren monotherapy has not been reported. This was a post hoc analysis of the subgroup of patients with stage 2 systolic hypertension (baseline mean s …
4GJA: A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
4GJC: A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
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TY - JOUR. T1 - Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. AU - Feng, Yangbo. AU - Yin, Yan. AU - Weiser, Amiee. AU - Griffin, Evelyn. AU - Cameron, Michael D.. AU - Lin, Li. AU - Ruiz, Claudia. AU - Schürer, Stephan C.. AU - Inoue, Toshihiro. AU - Rao, P. Vasanth. AU - Schröter, Thomas. AU - LoGrasso, Philip. PY - 2008/11/13. Y1 - 2008/11/13. N2 - The identification of a new class of potent and selective ROCK-II inhibitors is presented. Compound 5 (SR-3677) had an IC50 of ∼3 nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 nonkinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation.. AB - The identification of a new class of potent and selective ROCK-II inhibitors is presented. ...
TABLE-US-00002 TABLE 2 Ex Characterizations 01 1H NMR spectrum (d6-DMSO, δ in ppm): 1.48 to 1.70 (m, 6H), 3.62 (broad unresolved m, 2H), 4.08 (broad unresolved m, 2H), 4.59 (d, J = 5.5 Hz, 2H), 5.27 (t, J = 5.5 Hz, 1H), 7.37 (broad d, J = 7.5 Hz, 1H), 7.48 (t, J = 7.5 Hz, 1H), 7.58 (broad d, J = 7.5 Hz, 1H), from 7.62 to 7.73 (m, 3H), 8.30 (s, 1H), 8.91 (t, J = 1.5 Hz, 1H). Mass spectrum (LC-MS-DAD-ELSD): m/z 336 [M + H].sup.+. 02 1H NMR spectrum (d6-DMSO, δ in ppm): 4.31 (m, 2H), 4.44 (m, 2H), 4.60 (d, J = 5.7 Hz, 2H), 5.27 (t, J = 5.7, Hz, 1H), 6.85 (m, 1H), 6.92 (dd, J = 8.1, 1.6 Hz, 1H), 7.05 (m, 1H), 7.38 (dt, J = 7.6, 1.4 Hz, 1H), 7.48 (t, J = 7.6 Hz, 1H), 7.59 (dt, J = 7.6, 1.4 Hz, 1H), 7.65-7.77 (m, 4H), 8.46 (s, 1H), 8.96 (t, J = 1.6 Hz, 1H). Mass spectrum (LC-MS-DAD-ELSD): m/z 386 [M + H].sup.+. 03 1H NMR spectrum (d6-DMSO, δ in ppm): 3.67 (broad unresolved m, 6H), 4.27 (broad unresolved m, 2H), 4.59 (d, J = 5.5 Hz, 2H), 5.28 (t, J = 5.5 Hz, 1H), 7.37 (broad d, J = 7.5 Hz, 1H), 7.48 ...
So basically Im at a loss as to how to proceed. I started with the idea of converting the primary alcohol into an aldehyde and that is where I stoped. I understand that each substituent of the Nitrogen is somehow made from B, C and D and that the cynaonitrile is supposed to help you make the amide and the Gringnard Reagent is for adding a methyl group somewhere, maybe to C. Im completely at a loss and Im just getting frustrated now :(. ...
Used for treating high blood pressure. It may be used alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. Aliskiren is a direct renin inhibitor. It works by relaxing blood vessels. This lowers blood pressure and helps the heart to pump blood more easily.
Indications: Aliskiren (Tekturna®), a direct renin inhibitor, was approved by the fda for the treatment of patients with hypertension (htn)
TY - JOUR. T1 - Remarkably high catalyst efficiency of a disilaruthenacyclic complex for hydrosilane reduction of carbonyl compounds. AU - Tahara, Atsushi. AU - Sunada, Yusuke. AU - Takeshita, Takashi. AU - Inoue, Ryoko. AU - Nagashima, Hideo. N1 - Publisher Copyright: © 2018 The Royal Society of Chemistry. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2018. Y1 - 2018. N2 - A disilaruthenacyclic complex (1) showed extremely high catalytic activity for hydrosilane reduction of aldehydes and ketones to silyl ethers and secondary and tertiary amides to the corresponding amines. An σ-CAM mechanism was proposed to explain the activity.. AB - A disilaruthenacyclic complex (1) showed extremely high catalytic activity for hydrosilane reduction of aldehydes and ketones to silyl ethers and secondary and tertiary amides to the corresponding amines. An σ-CAM mechanism was proposed to explain the activity.. UR - ...
This study will investigate the analgesic efficacy of intraperitoneal ropivacaine instillation + parietal ropivacaine infiltration for the prevention of
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Principal Investigator:KOKUBU Tatsuo, Project Period (FY):1986 - 1987, Research Category:Grant-in-Aid for Developmental Scientific Research, Research Field:Circulatory organs internal medicine
accumulated accuracy accurate acquisition acquisitions alter alternative alters amide analyses apparent appears applications applied approaches approximately around asymmetric asymmetry audience bearing biological bore brain called coefficient combining compartment compartments confounding contrast contrasts correct correction corrections correlated correlation correlations defined dependence dependent developed direct duration endogenous enhancement evaluated exchange exists explanation extracellular full gore gradient heterogeneity horizontal in vivo influenced influences injection injections institute integrated interestingly interleaved intracellular intravenous introduced invalidate inversely inversion john lifetime likely linear longitudinal magnetization male mapping measured medical metric mobile model monitor much namely necessary need nuclear offset offsets origins overall overlaid peptides physics pixel pool procedures proposed proteins protocol proton protons pulse pulses ...
academy according accurate advanced agent aims although amide among appearing approved asymmetric benefit biomedical bulk cancer capability central characteristic characteristics chemical china classification clinical committee compensated conducted consent contrast corrected criteria curve decisions defined dehydrogenase determination determined diagnoses diagnosis discrimination duration either enables enhanced equally ethics evaluate evaluation examination exchange exhibits experienced expression feasibility field focused frequency grade grades great healthcare histopathology identification importance inclusion informed injection institutes institutional intravenous lesion lesions local long males maps materials medical minutes mutant mutation nervous neurosurgery noninvasive normalized offsets operating patients peptide pioneer plot positioned predict prediction previously probe prognostic program promoter prompt protein proton protons pulses receiver recruited recruitment registered ...
In this report, Persistence Market Research (PMR) delivers an analysis of the global Fatty Amides market from 2014-2018 and forecast for 2019-2029. The main objective of the report is to recognize opportunities in the market and offer key insights pertaining to various segments of the global fatty amides market. This report offers a comprehensive analysis of the fatty amides market in terms of market volume (tons), value (US$ Mn), and growth on the basis of segmentation, which includes product type, form and region.. The report initiates with a summary of the global fatty amides market, considering market performance in terms of value and volume, followed by PMRs analysis of crucial drivers, trends and restraints observed in the global market. Key trends specific to different regions are also included in the report to provide the client with decision-making and crystal-clear insights. The fatty amides report considers 2018 as the base year, with the valuation of market values for 2019 and a ...
The pharmacokinetics, biotransformation, and urinary excretion of ropivacaine (Naropin), a new local anesthetic agent, have been studied in six healthy male volunteers after a 15-min iv infusion of 152 mumol (50 mg) of [14C]ropivacaine, with a specific radioactivity of 22.5 kBq/mumol (8.8 kBq/mg). Blood, urine, and feces were collected for up to 96 hr after administration. The plasma and urine samples were analyzed for unchanged ropivacaine and for four of its metabolites, i.e. 3-OH-2,6-pipecoloxylidide (3-OH-PPX), 4-OH-ropivacaine, 3-OH-ropivacaine, and the N-dealkylated metabolite PPX, using GC and HPLC methods. The presence of 2,6-xylidine in plasma was also analyzed. The metabolites were quantified after acidic hydrolysis. The radioactivity could be followed in plasma for up to 14 hr after administration, with ropivacaine being the predominant compound in the early samples. The concentrations of the aforementioned metabolites in plasma were below or just above the lower limit of ...
傳統製備聚醯亞胺是加成聚合二胺與二酸單體於高極性溶劑形成前驅物-聚醯胺酸,加熱使聚醯胺酸轉變為聚醯亞胺,其環化溫度需高於350 oC且環化時間長,此高溫製程可能會損害相關之電子元件及產生高熱應力等問題。本研究的目的即為開發新型低溫環化製程的聚醯亞胺,其環化溫度低於250 oC且具有優良機械性質、熱性質及電學性質。許多學者研究以添加酸性觸媒或鹼性觸媒來降低其環化溫度,觸媒的主要作用是促進Carboxylate ion對Amide carbonyl unit的親核性攻擊,產生Isoimide的中間物,降低聚醯胺酸變成聚醯亞胺的活化能,能有效降低環化溫度。在1966年 J. A. Kreuz 等人發現在聚醯胺酸內添加 Triethylamine 能有效增加環化速率,隨著溫度越高其環化速率越大且環化程度越高;在1966年 M. Oba 發現具有雙官能機團的觸媒才具有使聚醯胺酸在低溫完全環化的能力。在2004年 K.
Thus, our data indicate that treatment with aliskiren, given on top of valsartan therapy, improves altered vascular remodelling in hypertensive patients.
New Amides of Arachidonic-Acid as Potential Antiinflammatory Drugs: A Preliminary Study, Autore G, Marzocco S, Palladino C, Saturnino C, Sinicropi S, Spagnuolo A. Vivacqua E, A. Ca
5-(4-(4-Fluorobenzyl)piperazine-1-carbonyl)-N-(4-phenoxyphenyl) picolinamide | C30H27FN4O3 | CID 56652375 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Get Details of Amidation Manufacturers,Amidation Suppliers,Amidation Dealers, Amidation Exporters, Amidation Traders, Amidation Producers, Amidation Wholesalers, Amidation Companies
Rho-associated protein kinases (ROCK) are serine/threonine kinases involved in numerous cellular motility regulation processes from cell migration to cellular contractility and control of the amount of microfilaments.. ROCK1 and ROCK2 isoforms have been used as targets in virtual screening performed by Life Chemicals with Schrödinger software that has also been used for preparation of protein molecule conformations. Both ROCK kinase structures (PDB IDs: 2ESM and 4L6Q) were optimized with protein preparation tool. At the same time, a number of known ROCK1 and ROCK2 inhibitors with IC50 lower than 1.5 µM from ChEMBL were processed with LigPrep module to generate 3D conformers with different pH states (Epik). Further, all docking procedures were carried out with Glide (Fig. 1). Several H-bond constraints and hydrophobic regions were defined and were applied during the docking stage. Based on docking score values, the docked compounds from Life Chemicals Stock Collection were narrowed down ...
As the Baran lab peptide synthesis aficionado, Lara came on board to test the alkyl-alkyl cross-coupling reaction in one final chemoselectivity challenge: the direct modification of native peptides on the solid-phase. After all, if one has a reaction that is supposedly as easy as amide-bond formation, it better work on solid-phase. She prepared a handful of model peptides on Rink amide resin, each bearing a free side-chain (aspartic acid or glutamic acid) or a free α-carboxylic acid. The acids were activated on-resin as redox-active esters and then subjected directly to solid-phase nickel couplings with various diaklylzinc reagents. Before cleavage of the peptides from the solid support, all excess reagents were simply washed away, identical to the way excess peptide coupling reagents are washed away after amide bond formation on the solid-phase. In this way, we were able to repurpose age-old solid-phase synthesis techniques for late-stage, nickel-catalyzed C-C bond formation. Accessing the ...
DICOM images are created by sophisticated medical scan equipment. These images are special formats that cannot be read by normal graphics viewers. Therefore, to read DICOM images in Linux, you can use a software called AMIDE in Ubuntu. AMIDE is open source and is available at You can install AMIDE to your computer in…
N-N-Dicyclohexyl-2-benzothiazolsulfene amide, 4979-32-2. We, China N-N-Dicyclohexyl-2-benzothiazolsulfene amide supplier, provide quality of N-N-Dicyclohexyl-2-benzothiazolsulfene amide and related products from China.
TY - JOUR. T1 - Exploratory synthetic studies of the α-methoxylation of amides via cuprous ion-promoted decomposition of o-diazobenzamides. AU - Han, Gyoonhee. AU - LaPorte, Matthew G.. AU - McIntosh, Mathias C.. AU - Weinreb, Steven M.. AU - Parvez, Masood. PY - 1996/12/27. Y1 - 1996/12/27. N2 - A convenient nonelectrochemical amide oxidation method has been developed. The process involves a cuprous ion-promoted decomposition of o-diazobenzamides like 4, generated in situ from the corresponding o-aminobenzamides, to give N-acyliminium ion intermediate 9 via a 1,5-H-atom transfer, followed by metal-catalyzed oxidation of the resulting α-amidyl radical. The transformation produces α-methoxybenzamides 15 in good yields. An attempt was made to apply this oxidation method to a total synthesis of the alkaloid (-)-anisomycin (16). Scalemic o-aminobenzamide pyrrolidine derivatives 18a/18b underwent oxidation to give α-methoxylated amide substrates 19a/19b, respectively, in good yields. However, ...
Lysergic acid amides[edit]. Main article: Lysergamides. *Ergine (LSA, D-lysergic acid amide, LAA, LA-111) *IUPAC name: 9,10- ... There are 3 main classes of ergoline derivatives, the water-soluble amides of lysergic acid, the water-insoluble ergopeptines ( ... ergoline derivatives that contain a tripeptide structure attached to the basic ergoline ring in the same location as the amide ...
... and does not result in cross-allergy to amides.[13][14] Therefore, amides can be used as alternatives in those patients. ... Esters are prone to producing allergic reactions, which may necessitate the use of an amide. The names of each locally clinical ... Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom) ... the half-life of amide local anaesthetic agents may be drastically increased thus increasing the risk of overdose. ...
Thioamides are analogous to amides. Sulfonic, sulfinic and sulfenic acids, esters, amides, and related compounds[edit]. ... They are typically prepared by the reaction of amides with Lawesson's reagent. Isothiocyanates, with formula R−N=C=S, are found ... 1.10 Sulfonic, sulfinic and sulfenic acids, esters, amides, and related compounds. *1.11 Sulfonium, oxosulfonium and related ...
This reaction is observed for three unsaturated functional groups, namely thioesters, esters and amides.[15] ... This reaction is observed for three unsaturated functional groups, namely thioesters, esters and amides.[11] ...
Esters and amidesEdit. Acid-base-catalysed hydrolyses are very common; one example is the hydrolysis of amides or esters. Their ... Upon hydrolysis, an amide converts into a carboxylic acid and an amine or ammonia (which in the presence of acid are ... attacks the carbon of the carbonyl group of the ester or amide. In an aqueous base, hydroxyl ions are better nucleophiles than ... Only proteins with a certain tertiary structure are targeted as some kind of orienting force is needed to place the amide group ...
3.5.2: Cyclic amides/. Amidohydrolases. *Barbiturase. *Beta-lactamase. 3.5.3: Linear amidines/. Ureohydrolases. *Arginase ...
... specifically in linear amides. The systematic name of this enzyme class is N-succinyl-LL-2,6-diaminoheptanedioate ...
Related amides. Valnoctamide Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 ° ...
3.5.2: Cyclic amides/. Amidohydrolases. *Barbiturase. *Beta-lactamase. *Dihydroorotase. 3.5.3: Linear amidines/. Ureohydrolases ...
Akiyama, Masayasu; Katoh, Akira; Ogawa, Takuya (1989). "N-hydroxy amides. Part 8. Synthesis and iron(III)-holding properties of ...
Amides give thioamide. With 1,4-diketones the reagent forms thiophenes. It is also used to deoxygenate sulfoxides. The use of ...
Linda P, Stener A, Cipiciani A, Savelli G (January-February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic ...
Dehydration of amides and oximesEdit. Nitriles can be prepared by the dehydration of primary amides. In the presence of ethyl ... Two intermediates in this reaction are amide tautomer A and its phosphate adduct B.. In a related dehydration, secondary amides ... Nitrile hydratases are metalloenzymes that hydrolyze nitriles to amides. RCN + H2O → RC(O)NH2. These enzymes are used ... which is slower than the hydrolysis of the amide to the carboxylate (7.4 × 10−5 M−1 s−1). Thus, the base hydrolysis route will ...
Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L. (2015). "Enzymatic Synthesis of Amides". In Faber, Kurt; ...
Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L. (2015). "Enzymatic Synthesis of Amides". In Faber, Kurt; ... The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided. Oxidation of ...
amphiphilic amide) → Na. 2[Zn(NH. 2). 4]. 2 NH. 4I. (acid) + Zn(NH. 2). 2. (amphiphilic amide) → [Zn(NH. 3). 4]I. 2. Nitric ... For example, water and ammonia undergo such dissociation into hydronium and hydroxide, and ammonium and amide, respectively: 2 ... Under this definition, pure H2SO4 and HCl dissolved in toluene are not acidic, and molten NaOH and solutions of calcium amide ...
If the bond rotates slowly enough compared to the NMR time scale (e.g., amide bond), two different species can be detected by ... Hindered Internal Rotation of Amides". The Journal of Chemical Physics. 25 (6): 1228-1234. Bibcode:1956JChPh..25.1228G. doi: ...
Delgado, Pierre (1946). Un grand ami des enfants. Le père Brottier (in French). Paris. Cristiani, Léon (1963). Le Serviteur de ...
... amides (R-C(O)-NR2). There are many important organic solvents that contain oxygen, among which: acetone, methanol, ethanol, ...
DeRuiter J (2005). "Amides and Related Functional Groups". Principles of Drug Action. p. 1. US Food and Drug Administration. " ... These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to ... procainamide contains an amide group. This substitution is the reason why procainamide exhibits a longer half-life time than ... the amide nitrogen. In certain lines, the para-amino group might become a target site to attach further paraphernalia, e.g. ref ...
Amides, primary and secondary amines. Carbamates typically do not tolerate the reaction conditions, but tert-butyl carbamates ( ... The methodology has been extended to intramolecular reactions With amides instead of esters the reaction product is an ... De Meijere reaction of disubstituted alkenes bearing carboxylic amide groups". Organic & Biomolecular Chemistry. 1 (17): 3007-9 ... Azaoligoheterocycles by Ti-Mediated Intramolecular Reductive Cyclopropanation of Cyclic Amino Acid Amides". Chemistry: A ...
They are typically prepared by the reaction of amides with Lawesson's reagent. Isothiocyanates, with formula R−N=C=S, are found ... Thioamides are analogous to amides. Sulfonic acids have functionality R−S(=O)2−OH. They are strong acids that are typically ...
The formation of amide is promoted by CDI. Although the reactivity of CDI is less than acid chlorides, it is more easily ... CDI is mainly employed to convert amines into amides, carbamates, ureas. It can also be used to convert alcohols into esters. ... "Syntheses Using Heterocyclic Amides (Azolides)". Angewandte Chemie International Edition in English. 1 (7): 351-367. doi: ...
Verley, A. (1893). "Sur la préparation des amides en général" [On the preparation of amides in general]. Bulletin de la Société ... As for most amides, the spectroscopic evidence indicates partial double bond character for the C-N and C-O bonds. Thus, the ... As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solvent ... Hindered Internal Rotation of Amides". J. Chem. Phys. 25 (6): 1228-1234. Bibcode:1956JChPh..25.1228G. doi:10.1063/1.1743184. ...
... although usually referred to as alkali metal amides. Examples include lithium amide, sodium amide, and potassium amide. These ... 2 are almost invariably referred to as amides, despite the fact that amide also refers to the organic functional group -C(O)NR ... P. W. Schenk (1963). "Lithium amide". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry, 2nd Ed. 1. NY,NY: ... O. Glemser, H. Sauer (1963). "Silver Amide". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry. 1 (2nd ed.). New ...
Making an amide is one of the processes which require ammonia as a reactant. There are other processes of preparing an amide ... "Making Amide". Chemguide. n.d. Retrieved May 21, 2019. "Simple Reactions of Carboxylic Acids as Acids". Chemistry Libretexts. ... From this reaction, the products are symmetrical primary amides, asymmetrical primary/ secondary diamides, and symmetrical ... the reaction of a primary amine or secondary amine with a carboxylic acid or with a carboxylic acid derivative to form an amide ...
doi:10.1038/368726a0.CS1 maint: multiple names: authors list (link). Greenlee, K. W.; Henne, A. L. (1946). Sodium Amide. ...
i. Meyers, A.; Ann Hanagan, M.; l. Mazzu, A. (1981). "2-Oxazolines from Amides via Imidates". Heterocycles. 15: 361. doi: ...
I. Amides from Alkenes and Mononitriles". Journal of the American Chemical Society. 70 (12): 4045-8. doi:10.1021/ja01192a022. ... The Ritter reaction is a chemical reaction that transforms a nitrile into an N-alkyl amide using various electrophilic ... Otherwise, the Ritter reaction is most useful in the formation of amines and amides of pharmaceutical interest. Real world ... The resulting nitrilium ion is hydrolyzed by water to the desired amide. Primary, secondary, tertiary, and benzylic alcohols, ...
Stevens, T. E. (1966). "Rearrangement of Amides with Iodine Pentafluoride". Journal of Organic Chemistry. 31 (6): 2025-2026. ...
... are nitrogen-containing organic compounds with the general formula. Amides are formed when carboxylic acids ... The amide linkage is found in many useful synthetic polymers such as nylon. Amides are formed when amino acids react to form ...
English version of Chinese product page To read more in English about Huntsmans product range please return to the home page, select language "English" then navigate to "Products" in the header menu.. ...
... glycolic amides having a strong herbicidal action, herbicides containing these active ingredients, a process for controlling ... The new O-(aminosulfonyl)-glycolic amides may be prepared from a glycolic amide and an aminosulfonyl halide in accordance with ... substituted alkylsulfonylglycolic amides and imides substituted alkylaminosulfonylglycolic amides and imides substituted ... The glycolic amides used as starting materials may be prepared analogously to the process described in J. Chem. Soc., 1357, ...
A method of producing an amide from the corresponding nitrile comprising the following steps, i) providing a microorganism ... 5. A method according to claim 1 in which the amide is an ethylenically unsaturated amide, preferably acrylamide or ... This process is of particular value when the nitrile is acrylonitrile and the amide is acrylamide. It is desirable to carry out ... iv) contacting the nitrile by the microorganism in an aqueous medium and thereby converting the nitrile to the amide, wherein ...
... is a lipid (CHEBI:18059) fatty amide (CHEBI:29348) is a monocarboxylic acid amide (CHEBI:29347) ... N-oleoyldopamine (CHEBI:31883) is a fatty amide (CHEBI:29348). N-oleoylglycine (CHEBI:73723) is a fatty amide (CHEBI:29348). N- ... fatty amide (CHEBI:29348) has functional parent fatty acid (CHEBI:35366) fatty amide (CHEBI:29348) is a fatty acid derivative ( ... Myxalamid D (CHEBI:31875) is a fatty amide (CHEBI:29348). Myxalamid S (CHEBI:31876) is a fatty amide (CHEBI:29348). N,N-bis(3- ...
Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and ... The alkali metal amides, MNH2 (M = Li, Na, K) are commercially available. Sodium amide (also known as sodamide) is synthesized ... Metal amides (systematic name metal azanides) are a class of coordination compounds composed of a metal center with amide ... Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by ...
Sodium amide definition, a white, crystalline, water-insoluble, flammable powder, NaNH2, used chiefly in the manufacture of ... Words nearby sodium amide. sodger, sod house, sodic, sodio-, sodium, sodium amide, sodium ammonium phosphate, sodium amytal, ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Other names: Docosanamide; Behenamide; Behenic acid amide; Docsoamide; Kemamide B; Uniwax 1747 ...
... amide ligands and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis( ... amide. In line with the general method, bis(trimethylsilyl)amides of transition metals are prepared by a reaction between the ... Cage Complexes of N-Heterocyclic Amide and Bis(trimethylsilyl)amide Ligands: Synthesis, Structure, and Magnetic Properties". ... Metal bis(trimethylsilyl)amides are strong bases. They are corrosive, and are incompatible with many chlorinated solvents. ...
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Package amide. *jessie (oldoldstable) (graphics): software for Medical Imaging 1.0.5-2+b2: amd64 armel armhf i386 ... You have searched for packages that names contain amide in all suites, all sections, and all architectures. Found 4 matching ...
... pyridine-4-carboxamide Pyridine-4-carboxylic acid amide pyridine-4-carboxylic acid amide 4- ... isonicotinic acid amide
Local Anesthetics, Amides. Class Summary. Local anesthetics block the initiation and conduction of nerve impulses. Anesthetics ...
Local Anesthetics, Amides. Class Summary. Local anesthetics block the initiation and conduction of nerve impulses.Anesthetics ... Lidocaine is an amide local anesthetic used in 1-2% concentration. The 1% preparation contains 10 mg of lidocaine for each 1 mL ...
Angiotensin amide definition at, a free online dictionary with pronunciation, synonyms and translation. Look it ...
AMIDE: (Amides a Medical Imaging Data Examiner) AMIDE is a tool for viewing and analyzing medical image data sets such as ...
An amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/),[1][2][3] also known as an acid amide, is a compound with the functional group RnE( ... Amide synthesisEdit. Many methods exist in amide synthesis.[9] On paper, the simplest method for making amides is by coupling a ... In primary and secondary amides, the presence of N-H dipoles allows amides to function as H-bond donors as well. Thus amides ... "amide - Definition of amide in English by Oxford Dictionaries". Oxford Dictionaries - English. Retrieved 15 April 2018.. ...
Acylaminosalicylic acid amides and their uses as pesticides. DE2210861A1. Mar 7, 1972. Sep 13, 1973. Hans Wirth Automaten. ... Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof. US 6380386 B2 ... Halobenzyl substituted phenylaceto esters and amides and use thereof for prevention of harmful organisms. ... benz-amide, are already known (compare, for example, Biochim. Biophys. Acta (1993), 1142(3), 262-8, J. Med. Chem. (1990), 33(1 ...
Fatty-acid amide hydrolase 1 (IPR030560). Short name: FAAH Family relationships *Amidase (IPR000120) *Fatty-acid amide ... Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of ... Structure and function of fatty acid amide hydrolase.. Annu. Rev. Biochem. 74 411-32 2005 ...
DISTEARYL PHTHALIC ACID AMIDE. Click here for all products containing this ingredient ...
Amides, C16-C18 (even numbered) EC Number:. 931-695-7. Molecular formula:. not available UVCB IUPAC Name:. Amides, C16-C18 ( ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Synthetic Anthranilic Acid Amides. Results of tests on selected, highly pure anthranilic acid amides with cinnamic acid partial ... 2. Extraction of Anthranilic Acid Amide Fractions from Plants. EXAMPLE 3. Extraction of an anthranilic acid amide-containing ... GS101100-A: Anthranilic acid amide fraction from cultivated oats extract. Anthranilic acid amide content (sum of ... this publication does not report which anthranilic acid amide or which anthranilic acid amides from the group of the so-called ...
angiotensin amide synonyms, angiotensin amide pronunciation, angiotensin amide translation, English dictionary definition of ... angiotensin amide. n. Any of several polypeptide hormones, designated by Roman numerals, that are involved in the regulation of ... Angiotensin amide - definition of angiotensin amide by The Free Dictionary ... redirected from angiotensin amide). Also found in: Thesaurus, Medical, Encyclopedia. an·gi·o·ten·sin. (ăn′jē-ō-tĕn′sĭn). n.. ...
Derivatives: Sodium Tallowate, Tallow Acid, Tallow Amide, Tallow Amine, Talloweth-6, Tallow Glycerides, Tallow Imidazoline. ...
Identification of amide bioisosteres of triazole oxytocin antagonists.. Brown A1, Ellis D, Wallace O, Ralph M. ... A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. A range of ... The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left ...
polymeric amide synonyms, polymeric amide pronunciation, polymeric amide translation, English dictionary definition of ... Noun 1. polymeric amide - a polymer containing repeated amide groups polyamide nylon - a thermoplastic polyamide; a family of ... polymeric amide - a polymer containing repeated amide groups. polyamide. nylon - a thermoplastic polyamide; a family of strong ... polymeric amide. Also found in: Thesaurus.. Related to polymeric amide: polyimide, Polymide ...
... ester-amide) and the amide segment contributing the remainder. ... The particular class of poly(ester-amides) are those which ... ester-amide) polymers are disclosed which are particularly suitable as hot melt adhesive compositions particularly advantageous ... Blends Of Poly(Ester Amide) Polymers. US20080206306 *. 2 May 2008. 28 Aug 2008. Syed Faiyaz Ahmed Hossainy. Poly(ester amide) ... End-capped poly(ester amide) copolymers. US20060093842 *. 29 Oct 2004. 4 May 2006. Desnoyer Jessica R. Poly(ester amide) filler ...
MESSAGES/ /usr/share/man/man1/amide.1.gz /usr/share/menu/amide /usr/share/omf/amide/amide-C.omf /usr/share/omf/amide/ ... usr/share/doc/amide/todo.gz /usr/share/gnome/help/amide/C/amide.xml /usr/share/gnome/help/amide/C/figures/amide_main_window.png ... usr/share/gnome/help/amide/C/legal.xml /usr/share/gnome/help/amide/es/amide.xml /usr/share/gnome/help/amide/es/figures/amide_ ... usr/bin/amide /usr/share/applications/amide.desktop /usr/share/doc-base/amide /usr/share/doc/amide/README.Debian /usr/share/doc ...
  • Amides are formed when carboxylic acids react with amines . (
  • Due to the dual use of the word 'amide', there is debate as to how to properly and unambiguously name the derived anions of amides in the first sense (i.e., deprotonated acylated amines), a few of which are commonly used as nonreactive counterions. (
  • Tertiary amides are commonly derived from secondary amines (R′R″NH) and have the general structure RC(O)NR′R″. Amides are usually regarded as derivatives of carboxylic acids in which the hydroxyl group has been replaced by an amine or ammonia. (
  • Compared to amines , amides are very weak bases . (
  • Nitrogen containing organic compounds are of two important types and they are amines, amides. (
  • The reduction of nitriles and amides to the corresponding amines with tetra- n -butylammonium borohydride in dichloromethane has been reported, in which the other functional groups such as ester, nitro, and halogen attached to the aromatic ring are not affected. (
  • The reduction of nitriles and amides to the amines is a very important, but not so easy organic transformation. (
  • We wish herein to describe another convenient and efficient method for the reduction of nitriles and amides to the amines with tetra- n -butylammonium borohydride 3-6 in refluxing dichloromethane, in which the chemospecificity of tetra- n -butylammonium borohydride toward organic cyano and amide compounds was observed. (
  • The combination of amide activation by Tf 2 O with B(C 6 F 5 ) 3 -catalyzed hydrosilylation with TMDS enables a one-pot reduction of secondary amides to amines under mild conditions with broad applicability and excellent chemoselectivity for many sensitive functional groups. (
  • A series of amides containing different additional functional groups were reduced to their corresponding amines in very good yields. (
  • Reduction of secondary amides to imines and secondary amines has been achieved using low catalyst loadings of readily available iridium catalysts such as [Ir(COE) 2 Cl] 2 with diethylsilane as reductant. (
  • An expeditious and practical method for the reduction of various amides and lactams to amines in good to excellent yields is consisted of activation with Tf 2 O followed by reduction with sodium borohydride in THF at room temperature. (
  • A triruthenium cluster catalyzes the reaction of secondary amides with hydrosilanes, yielding a mixture of secondary amines, tertiary amines, and silyl enamines. (
  • This learning unit describes the reduction of amides to amines. (
  • With hydroxylamine hydrochloride as an additive, both aliphatic and aromatic amines could be used as coupling partners for the present reaction, leading to production of branched amides in high yields with excellent regioselectivities. (
  • Here, we describe a method where p -H 2 hyperpolarizes a range of amines, amides, carboxylic acids, alcohols, phosphates, and carbonates without changing their chemical identity. (
  • The simplest amides are derivatives of ammonia wherein one hydrogen atom has been replaced by an acyl group. (
  • One of the carboxylic acid derivatives is amide. (
  • An example of such compounds is hydroxycinnamic acids ( p -coumaric, caffeic, ferulic, and sinapic) and their derivatives (esters, amides, and glycosides) which possess a pool of biological activities, including and antidiabetic effects [ 28 - 32 ]. (
  • Mass spectral analysis of compounds 4p-q , 5a-g , 6 , and 7 revealed the different cleavage pathway patterns that can help in identifying the structures of steviolbioside and its amide derivatives. (
  • The mass spectrometry of these safe and sweet compounds such as steviol, isosteviol, and steviolbioside and their amides and amide dimer derivatives are an interesting current subject. (
  • Síntese e atividade fitotóxica de amidas derivadas do ácido 6alfa,7beta-di-hidroxivouacapan-17beta-óico/ Synthesis and phytotoxic activity of new amide derivatives of 6alpha,7beta-Di-hydroxyvouacapan-17beta-oic acid. (
  • Esters, amides, and nitriles are carboxylic acid derivatives that can be prepared starting from either carboxylic acids or other carboxylic acid derivatives. (
  • The phenylthiocarbamyl (PTC)-amino acid amide derivatives were selectively taken up into the organic phase, while the other digestion products remained in the aqueous phase. (
  • Sodium amide (also known as sodamide) is synthesized from sodium metal and ammonia with ferric nitrate catalyst. (
  • Sodium amide is an example. (
  • On the other hand, amides are much stronger bases than carboxylic acids , esters , aldehydes , and ketones (their conjugate acids' p K a s are between −6 and −10). (
  • Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids, which act as new lipid mediators. (
  • Borane-tetrahydrofuran complex or borane-methyl sulfide complex is used to generate triacyloxyboranes, which can be effectively reacted with various nucleophiles (alkylamines, arylamines, hydrazides, alcohols, phenols) at reflux in toluene to provide the corresponding amides and esters in excellent yield. (
  • Metal bis(trimethylsilyl)amides form a significant subcategory of metal amide compounds. (
  • New, substituted O-(aminosulfonyl)-glycolic amides having a strong herbicidal action, herbicides containing these active ingredients, a process for controlling the growth of unwanted plants with these compounds, and a process for producing these compounds. (
  • The present invention relates to new and valuable substituted O-(aminosulfonyl)-glycolic amides, their manufacture, herbicides containing these compounds, and their use as herbicides. (
  • [4] The term amide refers both to classes of compounds and to the functional group (R n E(O) x NR′ 2 ) within those compounds. (
  • Amides are also chemical compounds . (
  • Amides are the members of a group of organic chemical compounds containing nitrogen . (
  • The mass spectra of a series of stevioside analogues including the amide and dimer compounds of steviol, isosteviol, and steviolbioside were examined. (
  • In the typical synthesis of amide reactions, alkylamines (1.1 eq) or alkyldiamines (2.1 eq) were added to a solution of title compounds (1.0 eq) in dried DMF (6 mL) at room temperature. (
  • RP-Amide is a new generation of ultra low-bleed, embedded polar group (EPG) phase that provides orthogonal selectivity and increased resolution for polar compounds. (
  • Deprotonation of ammonia with n -butyllithium offers a facile synthetic route to produce pure lithium amide exhibiting fine granularity, which facilitates the complete thermal decomposition to lithium imide at a relatively low temperature of 600 K. Synthesised compounds were characterised by high-resolution synchrotron X-ray diffraction, and the particle morphology of lithium amide was studied by transmission electron microscopy. (
  • they are necessarily secondary or tertiary amides. (
  • Tertiary amides are also known as disubstituted amides. (
  • A zinc-catalyzed reduction of tertiary amides shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents. (
  • Diethylzinc (Et 2 Zn) is an efficient and chemoselective catalyst for the reduction of tertiary amides under mild reaction conditions employing polymeric silane (PMHS) as a cost-effective hydride source. (
  • Conversions of nitriles to N-substituted secondary or tertiary amides are also quite practical, although they often require more than one chemical step. (
  • A monocarboxylic acid amide derived from a fatty acid. (
  • For instance, the amide derived from acetic acid is named acetamide (CH 3 CONH 2 ). (
  • Thus, the amide formed from dimethylamine and acetic acid is N , N -dimethylacetamide (CH 3 CONMe 2 , where Me = CH 3 ). (
  • While the conjugate acid of an amine has a p K a of about 9.5, the conjugate acid of an amide has a p K a around −0.5. (
  • Therefore, amides don't have as clearly noticeable acid-base properties in water . (
  • Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signalling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide [ PMID: 15952893 ]. (
  • Structure and function of fatty acid amide hydrolase. (
  • The particular class of poly(ester-amides) are those which include a polymeric fat acid, and more specifically a dimeric fat acid component, in which the ester segments will contribute from about 20, preferably 35 to about 60 weight percent of the poly(ester-amide) and the amide segment contributing the remainder. (
  • The palmitoylethanolamide and oleamide enigmas : are these two fatty acid amides cannabimimetic? (
  • Palmitoylethanolamide (PEA) and oleamide are two fatty acid amides which 1) share some cannabimimetic actions with delta9-tetrahydrocannabinol, anandamide and 2-arachidonoylglycerol, and 2) may interact with proteins involved in the biosynthesis, action and inactivation of endocannabinoids. (
  • Specifically, an amide results from an acid , in which a carbon atom is double bonded to oxygen and also to an hydroxyl group, when the hydroxyl group is replaced by an amine . (
  • In this context, the aim of the current study is the evaluation of -glucosidase inhibitory potential of cinnamic and hydroxycinnamic acid amides with amino acid. (
  • The acid 17 can then be subjected to standard amide-bond forming techniques. (
  • Fatty Acid Amide Hydrolase: A Potential Target for Next Generatio. (
  • The activity of AEA at its receptors is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase (FAAH). (
  • Fatty acid amide hydrolase (FAAH) terminates the endocannabinoid signaling pathway that regulates numerous neurobehavioral processes in animals by hydrolyzing a class of lipid mediators, N-acylethanolamines (NAEs). (
  • The present study demonstrates the antiproliferative effect of retinoic acid amide in vitro and in vivo against human lung cancer cells. (
  • Retinoic acid amide also leads to G2/M-phase cell cycle arrest and apoptosis of lung cancer cells. (
  • Retinoic acid amide exhibited a synergistic effect on antiproliferative effects of methotrexate in lung cancer cells. (
  • The retinoic acid amide-treated tumors showed inhibition of JAK2/STAT3 activation and Bcl-XL expression. (
  • There was also increase in expression of caspase-3 and caspase-9 in tumors on treatment with retinoic acid amide. (
  • Thus, retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate. (
  • Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH −/− ) are severely impaired in their ability to degrade anandamide and when treated with this compound, exhibit an array of intense CB 1 -dependent behavioral responses, including hypomotility, analgesia, catalepsy, and hypothermia. (
  • One candidate enzyme responsible for regulating anandamide function is fatty acid amide hydrolase (FAAH), a membrane-associated serine hydrolase enriched in brain and liver ( 22 , 25 - 27 ). (
  • FAAH hydrolyzes anandamide and several other bioactive fatty acid amides in vitro ( 22 , 28 - 31 ), including N -palmitoyl ethanolamine ( 32 ), a postulated endogenous ligand for CB-like receptors, and the sleep-inducing lipid oleamide ( 33 ). (
  • Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. (
  • Amides are prepared by adding N , N ′-dicyclohexylcarbodiimide (DCC) and an amine (ammonia derivative in which one or more hydrogen atoms are replaced by alkyl or aryl units) to a carboxylic acid. (
  • investigated whether inhibition of fatty acid amide hydrolase (FAAH) alters responses of dorsal horn neurons in neuropathic pain ( Fig. 1 ). (
  • An amide , an aa kent as an acid amide , is a compoond wi the functional group R n E(O) x NR' 2 (R and R' refer tae H or organic groups). (
  • The structurally even simpler amino acid amide is also evaluated as a ligand, and selectivities up to 90% ee are obtained in the reduction of a number of aryl alkyl ketones. (
  • The Hull site is one of three fatty acid amide manufacturing plants in the Croda group with the others located in Gouda, Netherlands and Mianyang, China. (
  • Acetic Acid Amide, 42 Products Found. (
  • How do you find Acetic Acid Amide factory in china that can manufacture items? (
  • Type the keywords you're interested in such as Acetic Acid Amide and make direct contact with any desirable suppliers / manufacturers / wholesalers for more important details or find similar choices that are lidocaine, cheap oxalic acid, discount stearic acid. (
  • The synthetic amides of L-glutamic acid also exhibited activity against Ehrlich ascites carcinoma [ 6 ]. (
  • PTC-amino acid amides were identified and quantitated by comparing their elution positions and peak areas, respectively, with those of standards. (
  • They are also extensively used as precursors for the synthesis other bis(trimethylsilyl)amide complexes (see below). (
  • the aluminium complex may also be prepared by treating strongly basic lithium aluminium hydride with the parent amine: LiAlH4 + 4 HN(SiMe3)2 → Li(hmds) + Al(hmds)3 + 4 H2 An alternative synthesis of tetrasulfur tetranitride entails the use of a metal bis(trimethylsilyl)amide [(Me3Si)2N]2S as a precursor with pre-formed S-N bonds. (
  • Amide Technologies has developed groundbreaking peptide synthesis by building instruments capable of delivering high-purity peptides quickly. (
  • Synthesis and Study of Regular Poly(ester amide)s Based on Bis(.alpha. (
  • Various synthesis and rehydrogenation processes of lithium hydride (LiH) and magnesium amide (Mg(NH 2 ) 2 ) system with 8:3 molar ratio are investigated to understand the kinetic factors and effectively utilize the essential hydrogen desorption properties. (
  • Apart from linear amides, there are also cyclic amides. (
  • Cyclic amides are also known as lactams. (
  • Metal bis(trimethylsilyl)amides (often abbreviated as metal silylamides) are coordination complexes composed of a cationic metal with anionic bis(trimethylsilyl)amide ligands and are part of a broader category of metal amides. (
  • Apart from group 1 and 2 complexes, a general method for preparing metal bis(trimethylsilyl)amides entails reactions of anhydrous metal chloride with an alkali metal bis(trimethylsilyl)amides via a salt metathesis reaction: MCln + n Na(hmds) → M(hmds)n + n NaCl Alkali metal chloride formed as a by-product typically precipitates as a solid, allowing for its removal by filtration. (
  • The remaining metal bis(trimethylsilyl)amide is then often purified by distillation or sublimation. (
  • Lithium, sodium, and potassium bis(trimethylsilyl)amides are commercially available. (
  • The calcium and barium complexes may be prepared via the general method, by treating calcium iodide or barium chloride with potassium or sodium bis(trimethylsilyl)amide. (
  • It deprotonates the free amine to yield the magnesium bis(trimethylsilyl)amide, itself commercially available. (
  • Tin(II) bis(trimethylsilyl)amide is prepared from anhydrous tin(II) chloride and is commercially available. (
  • Me3Si)2N]2S is prepared by the reaction of lithium bis(trimethylsilyl)amide and sulfur dichloride (SCl2). (
  • The latter compound is a metal bis(trimethylsilyl)amide and can be synthesized by the reaction of selenium tetrachloride (SeCl4), selenium monochloride (Se 2Cl 2) and lithium bis(trimethylsilyl)amide. (
  • American Elements manufactures potassium bis(trimethylsilyl)amide solution in various concentrations and organic solvents such as THF, toulene, 2-methyltetrahydrofuran, and tert-butyl ether. (
  • Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and they are more stable and soluble than the other alkali metal analogs. (
  • Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by reaction of the amine with potassium, potassium hydride, n-butylpotassium, or benzylpotassium. (
  • Amide can also refer to azanide (the anion H 2 N − , conjugate base of ammonia ) or to an organic amine (an anion R 2 N − ). For discussion of these " anionic amides", see Alkali metal amides . (
  • When the amide is derived from a primary or secondary amine, the substituents on nitrogen are indicated first in the name. (
  • Amide ligands have two electron pairs available for bonding. (
  • In these two examples, the dimethylamido ligands are both bridging and terminal: Tris(dimethylamino)aluminium dimer Tris(dimethylamino)gallium dimer In practice, bulky amide ligands have a lesser tendency to bridge. (
  • Amide ligands may participate in metal-ligand π-bonding giving a complex with the metal center being co-planar with the nitrogen and substituents. (
  • The methyleneamino and hydroxyethylene replacements, which have been used elsewhere as transition-state inhibitors of enzymes, are poor mimics of the amide in these CCK-B receptor ligands. (
  • Amides and hydroxamic acids derived from α-amino acids were evaluated as ligands in combination with rhodium and iridium half-sandwich complexes in asymmetric transfer hydrogenation (ATH) of ketones. (
  • article{369f354d-3b18-4890-a9c0-a314ba490cb6, abstract = {Let's do the twist: The first twisted bis-amide is obtained by the benzylic oxidation of Tröger's base (TB). (
  • A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. (
  • Note: As the nomenclature of amides of sulfur acids is described (though less extensively) in Rule C-641.8 , the present Subsection is illustrated mostly for carbon acids. (
  • Sterically hindered substrates can be converted with s -BuLi/TMEDA at -90 C. The amides can be efficiently reduced with lithium aluminum hydride to the corresponding Mannich bases. (
  • The proposed methodology readily affords the production of pure lithium amide nanoparticles at both bench-top and commercial scale. (
  • Miyaoka H, Wang Y, Hino S, Isobe S, Tokoyoda K, Ichikawa T, Kojima Y. Kinetic Modification on Hydrogen Desorption of Lithium Hydride and Magnesium Amide System. (
  • This report is a professional and in-depth study on the current state of the Lithium Amide industry. (
  • The Lithium Amide market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. (
  • Lithium Amide industry import/export consumption, supply and demand figures and cost price and production value gross margins are also provided. (
  • The Lithium Amide industry development trends and marketing channels are analyzed. (
  • 1] in 2002 found that lithium-nitride reversibly absorbs a large amount of hydrogen and form a mixture of lithium-hydride and lithium-amide. (
  • 2. An absorbable stent formed of a material comprising a copolymer, wherein the copolymer comprises a poly(ester amide) block and a tyrosine di-peptide block. (
  • Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. (
  • The first member of the RF-amide peptide superfamily to be characterized, in 1977, was the cardioexcitatory peptide, FMRFamide, isolated from the ganglia of the clam Macrocallista nimbosa ( 1 ). (
  • The discovery, 12 years ago, that the RF-amide peptide kisspeptin, acting via GPR54, was essential for the onset of puberty and reproduction, has been a major breakthrough in reproductive physiology ( 2 - 4 ). (
  • Comparative studies on non-mammalian vertebrates and invertebrates allow major advances in the knowledge of the evolutionary history of the RF-amide peptide superfamily. (
  • They thus report that kisspeptin should be classified in the galanin/spexin family rather than in the RF-amide peptide family. (
  • As indicated above, the characterization of the first RF-amide peptide was carried out in a mollusk. (
  • Spectroscopic and chemical evidence reveals that the drug interacts noncovalently with its receptor, suggesting that the alpha-keto amid of FK506 serves as a surrogate for the twisted amide of a bound peptide substrate. (
  • The ensemble is generally represented as RC(O)NH 2 and is described as a primary amide. (
  • Primary amide is the one that has a nitrogen atom that is bonded to two hydrogen atoms. (
  • This thesis presents density functional theory calculations performed on Mg(NH2)2 (magnesium-amide). (
  • Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. (
  • This invention generally relates to poly(ester amide) block copolymers useful for forming a bioabsorbable device such as a stent or for coating an implantable device such as a drug-delivery stent. (
  • N- substituted primary and secondary amides may also be described as acylamines or, more specifically as monoacylamines and diacylamines, respectively. (
  • Classify each of the amides in Problem 17-101 as a primary, secondary, or tertiary amide. (
  • Given amide has to be classified as primary, secondary, or tertiary amide. (
  • Amides are also classified as primary, secondary, and tertiary amide. (
  • Secondary amide is the one that has a nitrogen atom that is bonded to one hydrogen atom and one alkyl (or aryl) group. (
  • Secondary amides are also known as monosubstituted amides. (
  • Tris(pentafluorophenyl)boron B(C 6 F 5 ) 3 is an effective catalyst for the reduction of tertiary and N -phenyl secondary amides in the presence of a silane. (
  • A chemoselective activation of a secondary amide with triflic anhydride in the presence of 2-fluoropyridine enables a mild reduction using triethylsilane, a cheap and rather inert reagent. (
  • Most common are carboxamides (organic amides) ( n = 1, E = C, x = 1), but many other important types of amides are known, including phosphoramides ( n = 2, E = P, x = 1 and many related formulas) and sulfonamides (E = S, x = 2). (
  • Phenol carbamates undergo an anionic ortho -Fries rearrangement to their corresponding amides in the presence of LDA. (
  • The angle between the two Gly 79 amide-I transition dipoles, estimated at 103° from linear IR spectroscopy and 110° from 2D IR spectroscopy, combined with the coupling led to a structural picture of the hydrophobic interface that is remarkably consistent with results from NMR on helix dimers. (
  • A certain class of poly(ester-amide) polymers are disclosed which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (
  • The particular class of poly(ester-amides) are those which include a polymeric fat. (
  • This invention relates to a certain class of poly(ester-amide) polymers which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (
  • Poly(ester-amide) adhesive compositions have been known for some time in the art, including the use as hot melt adhesives for various substrates such as metals, wood and plastics. (
  • Included in this background of poly(ester-amide) compositions are U.S. Pats. (
  • No. 3,650,999, related to poly(ester-amide) compositions, is generally useful as adhesives to a variety of substrates such as steel, aluminum, wood and plastic substrates. (
  • By the proper selection of reactants and using special polymerization techniques, a block copolymer poly(ester-amide) composition was prepared having certain advantages in high temperature properties over earlier adhesive compositions. (
  • Once the ester is in hand than the amides are straight forward to prepare. (
  • The remainder of this article is about the carbonyl - nitrogen sense of amide . (
  • Consequently, the nitrogen in amides is not pyramidal. (
  • One final thing to note when looking at the bonds of an amide is that there is also a hydrogen bond present between the active groups hydrogen and nitrogen atoms. (
  • The amide linkage is found in many useful synthetic polymers such as nylon. (
  • The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left hand side (biaryl replacement) substituents which gave good levels of oxytocin antagonism. (
  • I've come up with a synthetic route to amide-substituted triazolopyrazines - what do you think? (
  • The study revealed that the itaconyl m-phenylene amide polymer was a weak antioxidant, while itaconyl bisaniline- and itaconyl-o-tolidine amide polymers showed good anti-oxidation property. (
  • Croda Polymer Additives has announced plans to invest in the expansion of its amide capacity at their manufacturing site in Hull, United Kingdom. (
  • Transition metal amides are intermediates in the base-induced substitution of transition metal ammine complexes. (
  • Thus, the desired bisheterocyclo methanide and amide complexes should achieve the best from two worlds: the stabilisation abilities for future low-valent metal complexes and the reactivity of group 13 metals. (
  • This application demonstrates the suitability of the Ascentis RP-Amide for the analysis of the pesticides carbaryl, diuron, and propachlor, utilizing isocratic conditions and UV detection. (
  • No comments were found for Ascentis™ RP-Amide for the Analysis of Pesticides . (
  • Twisted Amide Analogues of Tröger's Base. (
  • The present invention relates to a method for the manufacture of amides from the corresponding nitrile using a biocatalyst that is a microorganism capable of producing a nitrile hydratase enzyme. (
  • The improved methods for the reduction of nitriles 1 and amides 2 with complex metal hydrides have been so far reported. (
  • These peptides increase tension of the pedal retractor muscle and, in conjunction with FMRF-amide, increase peak tension of the anterior byssus retractor muscle (ABRM). (
  • It has also put in front of the spotlights RF-amide peptides and has invigorated research on this superfamily of regulatory neuropeptides. (
  • The present Research Topic aims at illustrating major advances achieved, through comparative studies in (mammalian and non-mammalian) vertebrates and invertebrates, in the knowledge of RF-amide peptides in terms of evolutionary history and physiological significance. (
  • Use of Pico-Tag methodology in the chemical analysis of peptides with carboxyl-terminal amides. (
  • Identification of amide bioisosteres of triazole oxytocin antagonists. (
  • Vasopressin (-Leu-Gly-amide), oxytocin (-Gly-amide), Lys1 gamma 1-melanotropin (-Phe-amide), and various acetylated and non-acetylated forms of alpha-melanotropin (-Val-amide) were identified in the posterior pituitary extract. (
  • SABRE is used to hyperpolarize the transfer agent NH 2 R, where R is H or CH 2 Ph or CH 2 CH 2 Ph (etc.), which relays polarization to the analyte (HR″, route A), and R″ is amide, carboxyl, phosphate, or alkoxide (etc. (
  • Amides are formed when amino acids react to form proteins . (