Amides. Medical search

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.

Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.

Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.

Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.

Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.

Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.

The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.

Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.

A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.

NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.

The rate dynamics in chemical or physical systems.

The characteristic three-dimensional shape of a molecule.

A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

The process of cleaving a chemical compound by the addition of a molecule of water.

Peptides composed of between two and twelve amino acids.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.

Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).

A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Peptides composed of two amino acid units.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.

BENZOIC ACID amides.

A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.

Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.

Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

The addition of an organic acid radical into a molecule.

AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.

A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

A family of hexahydropyridines.

A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.

Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.

A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.

Enzymes that catalyze the transfer of nitrogenous groups, primarily amino groups, from a donor, generally an amino acid, to an acceptor, usually a 2-oxoacid. EC 2.6.

GLYCEROL esterified with FATTY ACIDS.

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.

Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)

Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.

The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.

A group of 16-carbon fatty acids that contain no double bonds.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Organic compounds containing the radical -CSNH2.

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

The NADP-specific glutamate dehydrogenase of Neurospora crassa was digested with trypsin, and peptides accounting for 441 out of the 452 residues of the polypeptide chain were isolated and substantially sequenced. Additional experimental detail has been deposited as Supplementary Publication SUP 50052 (11 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem J. (1975) 145, 5. (+info)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use. (+info)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Peptic and chymotryptic peptides were isolated form the NADP-specific glutamate dehydrogenase of Neurospora crassa and substantially sequenced. Out of 452 residues in the polypeptide chain, 265 were recovered in the peptic and 427 in the chymotryptic peptides. Together with the tryptic peptides [Wootton, J. C., Taylor, J. G., Jackson, A. A., Chambers, G. K. & Fincham, J. R. S. (1975) Biochem. J. 149, 749-755], these establish the complete sequence of the chain, including the acid and amide assignments, except for seven places where overlaps are inadequate. These remaining alignments are deduced from information on the CNBr fragments obtained in another laboratory [Blumenthal, K. M., Moon, K. & Smith, E. L. (1975), J. Biol. Chem. 250, 3644-3654]. Further information has been deposited as Supplementary Publication SUP 50054 (17 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem. J. (1975) 145, 5. (+info)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

An extensive loss of a selected population of neurons in Alzheimer's disease is closely related to the formation of paired helical filaments (PHFs). The most striking characteristic of PHFs upon Western blotting is their smearing. According to a previously described protocol (Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Titani, K., and Ihara, Y. (1993) Neuron 10, 1151-1160), smeared tau was purified, and its peptide map was compared with that of soluble (normal) tau. A CNBr fragment from soluble tau (CN5; residues 251-419 according to the 441-residue isoform) containing the microtubule-binding domain migrated at 15 and 18 kDa on SDS-polyacrylamide gel electrophoresis, whereas that from smeared tau exhibited two larger, unusually broad bands at approximately 30 and approximately 45 kDa, presumably representing dimers and trimers of CN5. In the peptide map of smeared tau-derived CN5, distinct peaks eluting at unusual locations were noted. Amino acid sequence and mass spectrometric analyses revealed that these distinct peptides bear isoaspartate at Asn-381 and Asp-387. Because no unusual peptides other than aspartyl or isoaspartyl peptide were found in the digests of smeared tau-derived CN5, it is likely that site-specific deamidation and isoaspartate formation are involved in its dimerization and trimerization and thus in PHF formation in vivo. (+info)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing 100 microM GTPgammaS. 4. Pretreatment of CPAE cells with the Clostridium C2IN-C3 fusion toxin, which inactivates Rho by ADP ribosylation, significantly impaired the activation of ICl,swell in response to the HTS. The current density at +100 mV was 49 +/- 13 pA pF-1 (n = 17) in pretreated cells compared with 172 +/- 17 pA pF-1 (n = 21) in control cells. 5. The volume-independent activation of ICl,swell by intracellular perfusion with GTPgammaS was also impaired in C2IN-C3-pretreated cells (31 +/- 7 pA pF-1, n = 11) compared with non-treated cells (132 +/- 21 pA pF-1, n = 15). 6. Activation of ICl,swell was pertussis toxin (PTX) insensitive. 7. Y-27632, a blocker of Rho kinase, inhibited ICl,swell and delayed its activation. 8. Inhibition of Rho and of Rho kinase by the above-described treatments did not affect the extent of cell swelling in response to HTS. 9. These experiments provide strong evidence that the Rho-Rho kinase pathway is involved in the VRAC activation cascade. (+info)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

The role of a Rho-associated coiled-coil forming kinase in migration of neutrophils has been investigated. Rho-associated coiled-coil forming kinase I was expressed in human neutrophils. Chemotactic peptide led to a Rho-associated coiled-coil forming kinase-dependent increase in phosphorylation of myosin light chain. This was determined with the help of an antibody directed against serine 19-phosphorylated myosin light chain and an inhibitor of Rho-associated coiled-coil forming kinase (Y-27632). Y-27632 suppressed myosin light chain phosphorylation and chemotactic peptide-induced development of cell polarity and locomotion with similar potency (ED50 0.5-1.1 microM). The data strongly suggest that a Rho-associated coiled-coil forming kinase isoform, activated in human neutrophils exposed to chemotactic peptide, is important for motile functions of these cells. (+info)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity. (+info)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

BACKGROUND: Ropivacaine, 0.2%, is a new local anesthetic approved for epidural analgesia. The addition of 4 microg/ml fentanyl improves analgesia from epidural ropivacaine. Use of a lower concentration of ropivacaine-fentanyl may further improve analgesia or decrease side effects. METHODS: Thirty patients undergoing lower abdominal surgery were randomized in a double-blinded manner to receive one of three solutions: 0.2% ropivacaine-4 microg fentanyl 0.1% ropivacaine-2 microg fentanyl, or 0.05% ropivacaine-1 microg fentanyl for patient-controlled epidural analgesia after standardized combined epidural and general anesthesia. Patient-controlled epidural analgesia settings and adjustments for the three solutions were standardized to deliver equivalent drug doses. Pain scores (rest, cough, and ambulation), side effects (nausea, pruritus, sedation, motor block, hypotension, and orthostasis), and patient-controlled epidural analgesia consumption were measured for 48 h. RESULTS: All three solutions produced equivalent analgesia. Motor block was significantly more common (30 vs. 0%) and more intense with the 0.2% ropivacaine-4 microg fentanyl solution. Other side effects were equivalent between solutions and mild in severity. A significantly smaller volume of 0.2% ropivacaine-4 microg fentanyl solution was used, whereas the 0.1% ropivacaine-2 microg fentanyl group used a significantly greater amount of ropivacaine and fentanyl. CONCLUSIONS: Lesser concentrations of ropivacaine and fentanyl provide comparable analgesia with less motor block despite the use of similar amounts of ropivacaine and fentanyl. This finding suggests that concentration of local anesthetic solution at low doses is a primary determinant of motor block with patient-controlled epidural analgesia after lower abdominal surgery. (+info)

Lysergic acid amides[edit]. Main article: Lysergamides. *Ergine (LSA, D-lysergic acid amide, LAA, LA-111) *IUPAC name: 9,10- ... There are 3 main classes of ergoline derivatives, the water-soluble amides of lysergic acid, the water-insoluble ergopeptines ( ... ergoline derivatives that contain a tripeptide structure attached to the basic ergoline ring in the same location as the amide ...

https://en.wikipedia.org/wiki/Ergoline

... and does not result in cross-allergy to amides.[13][14] Therefore, amides can be used as alternatives in those patients. ... Esters are prone to producing allergic reactions, which may necessitate the use of an amide. The names of each locally clinical ... Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom) ... the half-life of amide local anaesthetic agents may be drastically increased thus increasing the risk of overdose. ...

https://en.wikipedia.org/wiki/Local_anesthetic

Thioamides are analogous to amides. Sulfonic, sulfinic and sulfenic acids, esters, amides, and related compounds[edit]. ... They are typically prepared by the reaction of amides with Lawesson's reagent. Isothiocyanates, with formula R−N=C=S, are found ... 1.10 Sulfonic, sulfinic and sulfenic acids, esters, amides, and related compounds. *1.11 Sulfonium, oxosulfonium and related ...

https://en.wikipedia.org/wiki/Organosulfur_compound

This reaction is observed for three unsaturated functional groups, namely thioesters, esters and amides.[15] ... This reaction is observed for three unsaturated functional groups, namely thioesters, esters and amides.[11] ...

https://en.wikipedia.org/wiki/Mass_spectrum_analysis

Esters and amidesEdit. Acid-base-catalysed hydrolyses are very common; one example is the hydrolysis of amides or esters. Their ... Upon hydrolysis, an amide converts into a carboxylic acid and an amine or ammonia (which in the presence of acid are ... attacks the carbon of the carbonyl group of the ester or amide. In an aqueous base, hydroxyl ions are better nucleophiles than ... Only proteins with a certain tertiary structure are targeted as some kind of orienting force is needed to place the amide group ...

https://en.m.wikipedia.org/wiki/Hydrolysation

3.5.2: Cyclic amides/. Amidohydrolases. *Barbiturase. *Beta-lactamase. 3.5.3: Linear amidines/. Ureohydrolases. *Arginase ...

https://en.wikipedia.org/wiki/GTP_cyclohydrolase_II

... specifically in linear amides. The systematic name of this enzyme class is N-succinyl-LL-2,6-diaminoheptanedioate ...

https://en.wikipedia.org/wiki/Succinyl-diaminopimelate_desuccinylase

Related amides. Valnoctamide Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 ° ...

https://en.wikipedia.org/wiki/Valpromide

3.5.2: Cyclic amides/. Amidohydrolases. *Barbiturase. *Beta-lactamase. *Dihydroorotase. 3.5.3: Linear amidines/. Ureohydrolases ...

https://en.wikipedia.org/wiki/HDAC4

Akiyama, Masayasu; Katoh, Akira; Ogawa, Takuya (1989). "N-hydroxy amides. Part 8. Synthesis and iron(III)-holding properties of ...

https://en.wikipedia.org/wiki/2-Bromoethyl_ether

Amides give thioamide. With 1,4-diketones the reagent forms thiophenes. It is also used to deoxygenate sulfoxides. The use of ...

https://en.wikipedia.org/wiki/Phosphorus_pentasulfide

Linda P, Stener A, Cipiciani A, Savelli G (January-February 1983). "Hydrolysis of amides. Kinetics and mechanism of the basic ...

https://en.wikipedia.org/wiki/1P-LSD

Dehydration of amides and oximesEdit. Nitriles can be prepared by the dehydration of primary amides. In the presence of ethyl ... Two intermediates in this reaction are amide tautomer A and its phosphate adduct B.. In a related dehydration, secondary amides ... Nitrile hydratases are metalloenzymes that hydrolyze nitriles to amides. RCN + H2O → RC(O)NH2. These enzymes are used ... which is slower than the hydrolysis of the amide to the carboxylate (7.4 × 10−5 M−1 s−1). Thus, the base hydrolysis route will ...

https://en.m.wikipedia.org/wiki/Nitrile

Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L. (2015). "Enzymatic Synthesis of Amides". In Faber, Kurt; ...

https://en.wikipedia.org/wiki/3-Methylpyridine

Schmidberger, J. W.; Hepworth, L. J.; Green, A. P.; Flitsch, S. L. (2015). "Enzymatic Synthesis of Amides". In Faber, Kurt; ... The enzyme allows for a more selective synthesis as further hydrolysis of the amide to nicotinic acid is avoided. Oxidation of ...

https://en.wikipedia.org/wiki/Nicotinonitrile

amphiphilic amide) → Na. 2[Zn(NH. 2). 4]. 2 NH. 4I. (acid) + Zn(NH. 2). 2. (amphiphilic amide) → [Zn(NH. 3). 4]I. 2. Nitric ... For example, water and ammonia undergo such dissociation into hydronium and hydroxide, and ammonium and amide, respectively: 2 ... Under this definition, pure H2SO4 and HCl dissolved in toluene are not acidic, and molten NaOH and solutions of calcium amide ...

https://en.wikipedia.org/wiki/Acid-base

If the bond rotates slowly enough compared to the NMR time scale (e.g., amide bond), two different species can be detected by ... Hindered Internal Rotation of Amides". The Journal of Chemical Physics. 25 (6): 1228-1234. Bibcode:1956JChPh..25.1228G. doi: ...

https://en.wikipedia.org/wiki/NMR_line_broadening_techniques

Delgado, Pierre (1946). Un grand ami des enfants. Le père Brottier (in French). Paris. Cristiani, Léon (1963). Le Serviteur de ...

https://en.wikipedia.org/wiki/Daniel_Brottier

... amides (R-C(O)-NR2). There are many important organic solvents that contain oxygen, among which: acetone, methanol, ethanol, ...

https://en.wikipedia.org/wiki/Compounds_of_oxygen

DeRuiter J (2005). "Amides and Related Functional Groups". Principles of Drug Action. p. 1. US Food and Drug Administration. " ... These are aromatic carboxylic acid derivatives consisting of an amide with a benzamide moiety and a triethylamine attached to ... procainamide contains an amide group. This substitution is the reason why procainamide exhibits a longer half-life time than ... the amide nitrogen. In certain lines, the para-amino group might become a target site to attach further paraphernalia, e.g. ref ...

https://en.wikipedia.org/wiki/Procainamide

Amides, primary and secondary amines. Carbamates typically do not tolerate the reaction conditions, but tert-butyl carbamates ( ... The methodology has been extended to intramolecular reactions With amides instead of esters the reaction product is an ... De Meijere reaction of disubstituted alkenes bearing carboxylic amide groups". Organic & Biomolecular Chemistry. 1 (17): 3007-9 ... Azaoligoheterocycles by Ti-Mediated Intramolecular Reductive Cyclopropanation of Cyclic Amino Acid Amides". Chemistry: A ...

https://en.wikipedia.org/wiki/Kulinkovich_reaction

They are typically prepared by the reaction of amides with Lawesson's reagent. Isothiocyanates, with formula R−N=C=S, are found ... Thioamides are analogous to amides. Sulfonic acids have functionality R−S(=O)2−OH. They are strong acids that are typically ...

https://en.wikipedia.org/wiki/Organosulfur_compounds

The formation of amide is promoted by CDI. Although the reactivity of CDI is less than acid chlorides, it is more easily ... CDI is mainly employed to convert amines into amides, carbamates, ureas. It can also be used to convert alcohols into esters. ... "Syntheses Using Heterocyclic Amides (Azolides)". Angewandte Chemie International Edition in English. 1 (7): 351-367. doi: ...

https://en.wikipedia.org/wiki/Carbonyldiimidazole

Verley, A. (1893). "Sur la préparation des amides en général" [On the preparation of amides in general]. Bulletin de la Société ... As for most amides, the spectroscopic evidence indicates partial double bond character for the C-N and C-O bonds. Thus, the ... As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solvent ... Hindered Internal Rotation of Amides". J. Chem. Phys. 25 (6): 1228-1234. Bibcode:1956JChPh..25.1228G. doi:10.1063/1.1743184. ...

https://en.wikipedia.org/wiki/Dimethylformamide

... although usually referred to as alkali metal amides. Examples include lithium amide, sodium amide, and potassium amide. These ... 2 are almost invariably referred to as amides, despite the fact that amide also refers to the organic functional group -C(O)NR ... P. W. Schenk (1963). "Lithium amide". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry, 2nd Ed. 1. NY,NY: ... O. Glemser, H. Sauer (1963). "Silver Amide". In G. Brauer (ed.). Handbook of Preparative Inorganic Chemistry. 1 (2nd ed.). New ...

https://en.wikipedia.org/wiki/Azanide

Making an amide is one of the processes which require ammonia as a reactant. There are other processes of preparing an amide ... "Making Amide". Chemguide. n.d. Retrieved May 21, 2019. "Simple Reactions of Carboxylic Acids as Acids". Chemistry Libretexts. ... From this reaction, the products are symmetrical primary amides, asymmetrical primary/ secondary diamides, and symmetrical ... the reaction of a primary amine or secondary amine with a carboxylic acid or with a carboxylic acid derivative to form an amide ...

https://en.wikipedia.org/wiki/Aminolysis

doi:10.1038/368726a0.CS1 maint: multiple names: authors list (link). Greenlee, K. W.; Henne, A. L. (1946). Sodium Amide. ...

https://en.wikipedia.org/wiki/Electride

i. Meyers, A.; Ann Hanagan, M.; l. Mazzu, A. (1981). "2-Oxazolines from Amides via Imidates". Heterocycles. 15: 361. doi: ...

https://en.wikipedia.org/wiki/Oxazoline

I. Amides from Alkenes and Mononitriles". Journal of the American Chemical Society. 70 (12): 4045-8. doi:10.1021/ja01192a022. ... The Ritter reaction is a chemical reaction that transforms a nitrile into an N-alkyl amide using various electrophilic ... Otherwise, the Ritter reaction is most useful in the formation of amines and amides of pharmaceutical interest. Real world ... The resulting nitrilium ion is hydrolyzed by water to the desired amide. Primary, secondary, tertiary, and benzylic alcohols, ...

https://en.wikipedia.org/wiki/Ritter_reaction

Stevens, T. E. (1966). "Rearrangement of Amides with Iodine Pentafluoride". Journal of Organic Chemistry. 31 (6): 2025-2026. ...

https://en.wikipedia.org/wiki/Iodine_pentafluoride

... are nitrogen-containing organic compounds with the general formula. Amides are formed when carboxylic acids ... The amide linkage is found in many useful synthetic polymers such as nylon. Amides are formed when amino acids react to form ...

http://hyperphysics.phy-astr.gsu.edu/hbase/Organic/amide.html

English version of Chinese product page To read more in English about Huntsmans product range please return to the home page, select language "English" then navigate to "Products" in the header menu.. ...

https://www.huntsman.com/corporate/a/Products/Chinese%20Product%20pages/Amides

... glycolic amides having a strong herbicidal action, herbicides containing these active ingredients, a process for controlling ... The new O-(aminosulfonyl)-glycolic amides may be prepared from a glycolic amide and an aminosulfonyl halide in accordance with ... substituted alkylsulfonylglycolic amides and imides substituted alkylaminosulfonylglycolic amides and imides substituted ... The glycolic amides used as starting materials may be prepared analogously to the process described in J. Chem. Soc., 1357, ...

http://www.freepatentsonline.com/4009192.html

A method of producing an amide from the corresponding nitrile comprising the following steps, i) providing a microorganism ... 5. A method according to claim 1 in which the amide is an ethylenically unsaturated amide, preferably acrylamide or ... This process is of particular value when the nitrile is acrylonitrile and the amide is acrylamide. It is desirable to carry out ... iv) contacting the nitrile by the microorganism in an aqueous medium and thereby converting the nitrile to the amide, wherein ...

https://www.freepatentsonline.com/y2007/0077633.html

... is a lipid (CHEBI:18059) fatty amide (CHEBI:29348) is a monocarboxylic acid amide (CHEBI:29347) ... N-oleoyldopamine (CHEBI:31883) is a fatty amide (CHEBI:29348). N-oleoylglycine (CHEBI:73723) is a fatty amide (CHEBI:29348). N- ... fatty amide (CHEBI:29348) has functional parent fatty acid (CHEBI:35366) fatty amide (CHEBI:29348) is a fatty acid derivative ( ... Myxalamid D (CHEBI:31875) is a fatty amide (CHEBI:29348). Myxalamid S (CHEBI:31876) is a fatty amide (CHEBI:29348). N,N-bis(3- ...

http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A29348

Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and ... The alkali metal amides, MNH2 (M = Li, Na, K) are commercially available. Sodium amide (also known as sodamide) is synthesized ... Metal amides (systematic name metal azanides) are a class of coordination compounds composed of a metal center with amide ... Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by ...

https://en.wikipedia.org/wiki/Metal_amides

Sodium amide definition, a white, crystalline, water-insoluble, flammable powder, NaNH2, used chiefly in the manufacture of ... Words nearby sodium amide. sodger, sod house, sodic, sodio-, sodium, sodium amide, sodium ammonium phosphate, sodium amytal, ...

https://www.dictionary.com/browse/sodium-amide

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

https://webbook.nist.gov/cgi/cbook.cgi?ID=C32837631&Units=CAL

Other names: Docosanamide; Behenamide; Behenic acid amide; Docsoamide; Kemamide B; Uniwax 1747 ...

https://webbook.nist.gov/cgi/inchi/InChI%3D1S/C22H45NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22

... amide ligands and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis( ... amide. In line with the general method, bis(trimethylsilyl)amides of transition metals are prepared by a reaction between the ... Cage Complexes of N-Heterocyclic Amide and Bis(trimethylsilyl)amide Ligands: Synthesis, Structure, and Magnetic Properties". ... Metal bis(trimethylsilyl)amides are strong bases. They are corrosive, and are incompatible with many chlorinated solvents. ...

https://en.wikipedia.org/wiki/Metal_bis(trimethylsilyl)amides

Compute answers using Wolframs breakthrough technology & knowledgebase, relied on by millions of students & professionals. For math, science, nutrition, history, geography, engineering, mathematics, linguistics, sports, finance, music…

https://www.wolframalpha.com/input/?i=FMOC+amide+under+reducing+conditions&lk=3

Package amide. *jessie (oldoldstable) (graphics): software for Medical Imaging 1.0.5-2+b2: amd64 armel armhf i386 ... You have searched for packages that names contain amide in all suites, all sections, and all architectures. Found 4 matching ...

https://packages.debian.org/search?keywords=amide&searchon=names&exact=1&suite=all§ion=all

... pyridine-4-carboxamide Pyridine-4-carboxylic acid amide pyridine-4-carboxylic acid amide 4- ... isonicotinic acid amide

https://scitoys.com/scichem/jqp065/15074.html

Local Anesthetics, Amides. Class Summary. Local anesthetics block the initiation and conduction of nerve impulses. Anesthetics ...

https://emedicine.medscape.com/article/1890801-medication

Local Anesthetics, Amides. Class Summary. Local anesthetics block the initiation and conduction of nerve impulses.Anesthetics ... Lidocaine is an amide local anesthetic used in 1-2% concentration. The 1% preparation contains 10 mg of lidocaine for each 1 mL ...

https://emedicine.medscape.com/article/1839735-medication

Angiotensin amide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ...

https://www.dictionary.com/browse/angiotensin-amide

AMIDE: (Amides a Medical Imaging Data Examiner) AMIDE is a tool for viewing and analyzing medical image data sets such as ...

https://directory.fsf.org/wiki/Amide

An amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/),[1][2][3] also known as an acid amide, is a compound with the functional group RnE( ... Amide synthesisEdit. Many methods exist in amide synthesis.[9] On paper, the simplest method for making amides is by coupling a ... In primary and secondary amides, the presence of N-H dipoles allows amides to function as H-bond donors as well. Thus amides ... "amide - Definition of amide in English by Oxford Dictionaries". Oxford Dictionaries - English. Retrieved 15 April 2018.. ...

https://en.m.wikipedia.org/wiki/Amide

Acylaminosalicylic acid amides and their uses as pesticides. DE2210861A1. Mar 7, 1972. Sep 13, 1973. Hans Wirth Automaten. ... Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof. US 6380386 B2 ... Halobenzyl substituted phenylaceto esters and amides and use thereof for prevention of harmful organisms. ... benz-amide, are already known (compare, for example, Biochim. Biophys. Acta (1993), 1142(3), 262-8, J. Med. Chem. (1990), 33(1 ...

http://www.google.com/patents/US6380386?dq=5,867,764

Fatty-acid amide hydrolase 1 (IPR030560). Short name: FAAH Family relationships *Amidase (IPR000120) *Fatty-acid amide ... Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of ... Structure and function of fatty acid amide hydrolase.. Annu. Rev. Biochem. 74 411-32 2005 ...

http://www.ebi.ac.uk/interpro/entry/IPR030560

DISTEARYL PHTHALIC ACID AMIDE. Click here for all products containing this ingredient ...

https://www.ewg.org/skindeep/ingredients/718798-DISTEARYL_PHTHALIC_ACID_AMIDE/

Amides, C16-C18 (even numbered) EC Number:. 931-695-7. Molecular formula:. not available UVCB IUPAC Name:. Amides, C16-C18 ( ...

https://echa.europa.eu/registration-dossier/-/registered-dossier/13244

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...

https://www.echa.europa.eu/web/guest/registration-dossier/-/registered-dossier/14427/4/15

Synthetic Anthranilic Acid Amides. Results of tests on selected, highly pure anthranilic acid amides with cinnamic acid partial ... 2. Extraction of Anthranilic Acid Amide Fractions from Plants. EXAMPLE 3. Extraction of an anthranilic acid amide-containing ... GS101100-A: Anthranilic acid amide fraction from cultivated oats extract. Anthranilic acid amide content (sum of ... this publication does not report which anthranilic acid amide or which anthranilic acid amides from the group of the so-called ...

http://www.google.com/patents/US8203016?dq=7,444,563

angiotensin amide synonyms, angiotensin amide pronunciation, angiotensin amide translation, English dictionary definition of ... angiotensin amide. n. Any of several polypeptide hormones, designated by Roman numerals, that are involved in the regulation of ... Angiotensin amide - definition of angiotensin amide by The Free Dictionary https://www.thefreedictionary.com/angiotensin+amide ... redirected from angiotensin amide). Also found in: Thesaurus, Medical, Encyclopedia. an·gi·o·ten·sin. (ăn′jē-ō-tĕn′sĭn). n.. ...

https://www.thefreedictionary.com/angiotensin+amide

Derivatives: Sodium Tallowate, Tallow Acid, Tallow Amide, Tallow Amine, Talloweth-6, Tallow Glycerides, Tallow Imidazoline. ...

http://www.ewg.org/skindeep/ingredient/718445/DIHYDROGENATED_TALLOW_PHTHALIC_ACID_AMIDE/

Identification of amide bioisosteres of triazole oxytocin antagonists.. Brown A1, Ellis D, Wallace O, Ralph M. ... A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. A range of ... The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left ...

https://www.ncbi.nlm.nih.gov/pubmed/20189387

polymeric amide synonyms, polymeric amide pronunciation, polymeric amide translation, English dictionary definition of ... Noun 1. polymeric amide - a polymer containing repeated amide groups polyamide nylon - a thermoplastic polyamide; a family of ... polymeric amide - a polymer containing repeated amide groups. polyamide. nylon - a thermoplastic polyamide; a family of strong ... polymeric amide. Also found in: Thesaurus.. Related to polymeric amide: polyimide, Polymide ...

https://www.thefreedictionary.com/polymeric+amide

... ester-amide) and the amide segment contributing the remainder. ... The particular class of poly(ester-amides) are those which ... ester-amide) polymers are disclosed which are particularly suitable as hot melt adhesive compositions particularly advantageous ... Blends Of Poly(Ester Amide) Polymers. US20080206306 *. 2 May 2008. 28 Aug 2008. Syed Faiyaz Ahmed Hossainy. Poly(ester amide) ... End-capped poly(ester amide) copolymers. US20060093842 *. 29 Oct 2004. 4 May 2006. Desnoyer Jessica R. Poly(ester amide) filler ...

http://www.google.com.au/patents/US4656242

MESSAGES/amide.mo /usr/share/man/man1/amide.1.gz /usr/share/menu/amide /usr/share/omf/amide/amide-C.omf /usr/share/omf/amide/ ... usr/share/doc/amide/todo.gz /usr/share/gnome/help/amide/C/amide.xml /usr/share/gnome/help/amide/C/figures/amide_main_window.png ... usr/share/gnome/help/amide/C/legal.xml /usr/share/gnome/help/amide/es/amide.xml /usr/share/gnome/help/amide/es/figures/amide_ ... usr/bin/amide /usr/share/applications/amide.desktop /usr/share/doc-base/amide /usr/share/doc/amide/README.Debian /usr/share/doc ...

https://packages.debian.org/sk/wheezy/kfreebsd-i386/amide/filelist

Amides are formed when carboxylic acids react with amines . (gsu.edu)
Due to the dual use of the word 'amide', there is debate as to how to properly and unambiguously name the derived anions of amides in the first sense (i.e., deprotonated acylated amines), a few of which are commonly used as nonreactive counterions. (wikipedia.org)
Tertiary amides are commonly derived from secondary amines (R′R″NH) and have the general structure RC(O)NR′R″. Amides are usually regarded as derivatives of carboxylic acids in which the hydroxyl group has been replaced by an amine or ammonia. (wikipedia.org)
Compared to amines , amides are very weak bases . (wikipedia.org)
Nitrogen containing organic compounds are of two important types and they are amines, amides. (bartleby.com)
The reduction of nitriles and amides to the corresponding amines with tetra- n -butylammonium borohydride in dichloromethane has been reported, in which the other functional groups such as ester, nitro, and halogen attached to the aromatic ring are not affected. (erowid.org)
The reduction of nitriles and amides to the amines is a very important, but not so easy organic transformation. (erowid.org)
We wish herein to describe another convenient and efficient method for the reduction of nitriles and amides to the amines with tetra- n -butylammonium borohydride 3-6 in refluxing dichloromethane, in which the chemospecificity of tetra- n -butylammonium borohydride toward organic cyano and amide compounds was observed. (erowid.org)
The combination of amide activation by Tf 2 O with B(C 6 F 5 ) 3 -catalyzed hydrosilylation with TMDS enables a one-pot reduction of secondary amides to amines under mild conditions with broad applicability and excellent chemoselectivity for many sensitive functional groups. (organic-chemistry.org)
A series of amides containing different additional functional groups were reduced to their corresponding amines in very good yields. (organic-chemistry.org)
Reduction of secondary amides to imines and secondary amines has been achieved using low catalyst loadings of readily available iridium catalysts such as [Ir(COE) 2 Cl] 2 with diethylsilane as reductant. (organic-chemistry.org)
An expeditious and practical method for the reduction of various amides and lactams to amines in good to excellent yields is consisted of activation with Tf 2 O followed by reduction with sodium borohydride in THF at room temperature. (organic-chemistry.org)
A triruthenium cluster catalyzes the reaction of secondary amides with hydrosilanes, yielding a mixture of secondary amines, tertiary amines, and silyl enamines. (organic-chemistry.org)
This learning unit describes the reduction of amides to amines. (chemgapedia.de)
With hydroxylamine hydrochloride as an additive, both aliphatic and aromatic amines could be used as coupling partners for the present reaction, leading to production of branched amides in high yields with excellent regioselectivities. (rsc.org)
Here, we describe a method where p -H 2 hyperpolarizes a range of amines, amides, carboxylic acids, alcohols, phosphates, and carbonates without changing their chemical identity. (sciencemag.org)

The simplest amides are derivatives of ammonia wherein one hydrogen atom has been replaced by an acyl group. (wikipedia.org)
One of the carboxylic acid derivatives is amide. (bartleby.com)
An example of such compounds is hydroxycinnamic acids ( p -coumaric, caffeic, ferulic, and sinapic) and their derivatives (esters, amides, and glycosides) which possess a pool of biological activities, including and antidiabetic effects [ 28 - 32 ]. (hindawi.com)
Mass spectral analysis of compounds 4p-q , 5a-g , 6 , and 7 revealed the different cleavage pathway patterns that can help in identifying the structures of steviolbioside and its amide derivatives. (hindawi.com)
The mass spectrometry of these safe and sweet compounds such as steviol, isosteviol, and steviolbioside and their amides and amide dimer derivatives are an interesting current subject. (hindawi.com)
Síntese e atividade fitotóxica de amidas derivadas do ácido 6alfa,7beta-di-hidroxivouacapan-17beta-óico/ Synthesis and phytotoxic activity of new amide derivatives of 6alpha,7beta-Di-hydroxyvouacapan-17beta-oic acid. (worldwidescience.org)
Esters, amides, and nitriles are carboxylic acid derivatives that can be prepared starting from either carboxylic acids or other carboxylic acid derivatives. (coursehero.com)
The phenylthiocarbamyl (PTC)-amino acid amide derivatives were selectively taken up into the organic phase, while the other digestion products remained in the aqueous phase. (biomedsearch.com)

Sodium amide (also known as sodamide) is synthesized from sodium metal and ammonia with ferric nitrate catalyst. (wikipedia.org)
Sodium amide is an example. (wikipedia.org)

On the other hand, amides are much stronger bases than carboxylic acids , esters , aldehydes , and ketones (their conjugate acids' p K a s are between −6 and −10). (wikipedia.org)
Endocannabinoids are amides, esters and ethers of long chain polyunsaturated fatty acids, which act as new lipid mediators. (ingentaconnect.com)
Borane-tetrahydrofuran complex or borane-methyl sulfide complex is used to generate triacyloxyboranes, which can be effectively reacted with various nucleophiles (alkylamines, arylamines, hydrazides, alcohols, phenols) at reflux in toluene to provide the corresponding amides and esters in excellent yield. (organic-chemistry.org)

Metal bis(trimethylsilyl)amides form a significant subcategory of metal amide compounds. (wikipedia.org)
New, substituted O-(aminosulfonyl)-glycolic amides having a strong herbicidal action, herbicides containing these active ingredients, a process for controlling the growth of unwanted plants with these compounds, and a process for producing these compounds. (freepatentsonline.com)
The present invention relates to new and valuable substituted O-(aminosulfonyl)-glycolic amides, their manufacture, herbicides containing these compounds, and their use as herbicides. (freepatentsonline.com)
[4] The term amide refers both to classes of compounds and to the functional group (R n E(O) x NR′ 2 ) within those compounds. (wikipedia.org)
Amides are also chemical compounds . (wikipedia.org)
Amides are the members of a group of organic chemical compounds containing nitrogen . (wikidoc.org)
The mass spectra of a series of stevioside analogues including the amide and dimer compounds of steviol, isosteviol, and steviolbioside were examined. (hindawi.com)
In the typical synthesis of amide reactions, alkylamines (1.1 eq) or alkyldiamines (2.1 eq) were added to a solution of title compounds (1.0 eq) in dried DMF (6 mL) at room temperature. (hindawi.com)
RP-Amide is a new generation of ultra low-bleed, embedded polar group (EPG) phase that provides orthogonal selectivity and increased resolution for polar compounds. (sigmaaldrich.com)
Deprotonation of ammonia with n -butyllithium offers a facile synthetic route to produce pure lithium amide exhibiting fine granularity, which facilitates the complete thermal decomposition to lithium imide at a relatively low temperature of 600 K. Synthesised compounds were characterised by high-resolution synchrotron X-ray diffraction, and the particle morphology of lithium amide was studied by transmission electron microscopy. (wiley.com)

they are necessarily secondary or tertiary amides. (wikipedia.org)
Tertiary amides are also known as disubstituted amides. (bartleby.com)
A zinc-catalyzed reduction of tertiary amides shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents. (organic-chemistry.org)
Diethylzinc (Et 2 Zn) is an efficient and chemoselective catalyst for the reduction of tertiary amides under mild reaction conditions employing polymeric silane (PMHS) as a cost-effective hydride source. (organic-chemistry.org)
Conversions of nitriles to N-substituted secondary or tertiary amides are also quite practical, although they often require more than one chemical step. (perfumerflavorist.com)

A monocarboxylic acid amide derived from a fatty acid. (ebi.ac.uk)
For instance, the amide derived from acetic acid is named acetamide (CH 3 CONH 2 ). (wikipedia.org)
Thus, the amide formed from dimethylamine and acetic acid is N , N -dimethylacetamide (CH 3 CONMe 2 , where Me = CH 3 ). (wikipedia.org)
While the conjugate acid of an amine has a p K a of about 9.5, the conjugate acid of an amide has a p K a around −0.5. (wikipedia.org)
Therefore, amides don't have as clearly noticeable acid-base properties in water . (wikipedia.org)
Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signalling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide [ PMID: 15952893 ]. (ebi.ac.uk)
Structure and function of fatty acid amide hydrolase. (ebi.ac.uk)
The particular class of poly(ester-amides) are those which include a polymeric fat acid, and more specifically a dimeric fat acid component, in which the ester segments will contribute from about 20, preferably 35 to about 60 weight percent of the poly(ester-amide) and the amide segment contributing the remainder. (google.com.au)
The palmitoylethanolamide and oleamide enigmas : are these two fatty acid amides cannabimimetic? (nih.gov)
Palmitoylethanolamide (PEA) and oleamide are two fatty acid amides which 1) share some cannabimimetic actions with delta9-tetrahydrocannabinol, anandamide and 2-arachidonoylglycerol, and 2) may interact with proteins involved in the biosynthesis, action and inactivation of endocannabinoids. (nih.gov)
Specifically, an amide results from an acid , in which a carbon atom is double bonded to oxygen and also to an hydroxyl group, when the hydroxyl group is replaced by an amine . (wikidoc.org)
In this context, the aim of the current study is the evaluation of -glucosidase inhibitory potential of cinnamic and hydroxycinnamic acid amides with amino acid. (hindawi.com)
The acid 17 can then be subjected to standard amide-bond forming techniques. (github.com)
Fatty Acid Amide Hydrolase: A Potential Target for Next Generatio. (ingentaconnect.com)
The activity of AEA at its receptors is limited by cellular uptake through a specific membrane transporter, followed by intracellular degradation by a fatty acid amide hydrolase (FAAH). (ingentaconnect.com)
Fatty acid amide hydrolase (FAAH) terminates the endocannabinoid signaling pathway that regulates numerous neurobehavioral processes in animals by hydrolyzing a class of lipid mediators, N-acylethanolamines (NAEs). (unt.edu)
The present study demonstrates the antiproliferative effect of retinoic acid amide in vitro and in vivo against human lung cancer cells. (springer.com)
Retinoic acid amide also leads to G2/M-phase cell cycle arrest and apoptosis of lung cancer cells. (springer.com)
Retinoic acid amide exhibited a synergistic effect on antiproliferative effects of methotrexate in lung cancer cells. (springer.com)
The retinoic acid amide-treated tumors showed inhibition of JAK2/STAT3 activation and Bcl-XL expression. (springer.com)
There was also increase in expression of caspase-3 and caspase-9 in tumors on treatment with retinoic acid amide. (springer.com)
Thus, retinoic acid amide exhibits promising antiproliferative effects against human lung cancer cells in vitro and in vivo and enhances the antiproliferative effect of methotrexate. (springer.com)
Here we show that mice lacking the enzyme fatty acid amide hydrolase (FAAH −/− ) are severely impaired in their ability to degrade anandamide and when treated with this compound, exhibit an array of intense CB 1 -dependent behavioral responses, including hypomotility, analgesia, catalepsy, and hypothermia. (pnas.org)
One candidate enzyme responsible for regulating anandamide function is fatty acid amide hydrolase (FAAH), a membrane-associated serine hydrolase enriched in brain and liver ( 22 , 25 - 27 ). (pnas.org)
FAAH hydrolyzes anandamide and several other bioactive fatty acid amides in vitro ( 22 , 28 - 31 ), including N -palmitoyl ethanolamine ( 32 ), a postulated endogenous ligand for CB-like receptors, and the sleep-inducing lipid oleamide ( 33 ). (pnas.org)
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. (uniprot.org)
Amides are prepared by adding N , N ′-dicyclohexylcarbodiimide (DCC) and an amine (ammonia derivative in which one or more hydrogen atoms are replaced by alkyl or aryl units) to a carboxylic acid. (coursehero.com)
investigated whether inhibition of fatty acid amide hydrolase (FAAH) alters responses of dorsal horn neurons in neuropathic pain ( Fig. 1 ). (jneurosci.org)
An amide , an aa kent as an acid amide , is a compoond wi the functional group R n E(O) x NR' 2 (R and R' refer tae H or organic groups). (wikipedia.org)
The structurally even simpler amino acid amide is also evaluated as a ligand, and selectivities up to 90% ee are obtained in the reduction of a number of aryl alkyl ketones. (diva-portal.org)
The Hull site is one of three fatty acid amide manufacturing plants in the Croda group with the others located in Gouda, Netherlands and Mianyang, China. (croda.com)
Acetic Acid Amide, 42 Products Found. (made-in-china.com)
How do you find Acetic Acid Amide factory in china that can manufacture items? (made-in-china.com)
Type the keywords you're interested in such as Acetic Acid Amide and make direct contact with any desirable suppliers / manufacturers / wholesalers for more important details or find similar choices that are lidocaine, cheap oxalic acid, discount stearic acid. (made-in-china.com)
The synthetic amides of L-glutamic acid also exhibited activity against Ehrlich ascites carcinoma [ 6 ]. (ijpsonline.com)
PTC-amino acid amides were identified and quantitated by comparing their elution positions and peak areas, respectively, with those of standards. (biomedsearch.com)

They are also extensively used as precursors for the synthesis other bis(trimethylsilyl)amide complexes (see below). (wikipedia.org)
the aluminium complex may also be prepared by treating strongly basic lithium aluminium hydride with the parent amine: LiAlH4 + 4 HN(SiMe3)2 → Li(hmds) + Al(hmds)3 + 4 H2 An alternative synthesis of tetrasulfur tetranitride entails the use of a metal bis(trimethylsilyl)amide [(Me3Si)2N]2S as a precursor with pre-formed S-N bonds. (wikipedia.org)
Amide Technologies has developed groundbreaking peptide synthesis by building instruments capable of delivering high-purity peptides quickly. (massbio.org)
Synthesis and Study of Regular Poly(ester amide)s Based on Bis(.alpha. (patentgenius.com)
Various synthesis and rehydrogenation processes of lithium hydride (LiH) and magnesium amide (Mg(NH 2 ) 2 ) system with 8:3 molar ratio are investigated to understand the kinetic factors and effectively utilize the essential hydrogen desorption properties. (mdpi.com)

Apart from linear amides, there are also cyclic amides. (bartleby.com)
Cyclic amides are also known as lactams. (bartleby.com)

Metal bis(trimethylsilyl)amides (often abbreviated as metal silylamides) are coordination complexes composed of a cationic metal with anionic bis(trimethylsilyl)amide ligands and are part of a broader category of metal amides. (wikipedia.org)
Apart from group 1 and 2 complexes, a general method for preparing metal bis(trimethylsilyl)amides entails reactions of anhydrous metal chloride with an alkali metal bis(trimethylsilyl)amides via a salt metathesis reaction: MCln + n Na(hmds) → M(hmds)n + n NaCl Alkali metal chloride formed as a by-product typically precipitates as a solid, allowing for its removal by filtration. (wikipedia.org)
The remaining metal bis(trimethylsilyl)amide is then often purified by distillation or sublimation. (wikipedia.org)
Lithium, sodium, and potassium bis(trimethylsilyl)amides are commercially available. (wikipedia.org)
The calcium and barium complexes may be prepared via the general method, by treating calcium iodide or barium chloride with potassium or sodium bis(trimethylsilyl)amide. (wikipedia.org)
It deprotonates the free amine to yield the magnesium bis(trimethylsilyl)amide, itself commercially available. (wikipedia.org)
Tin(II) bis(trimethylsilyl)amide is prepared from anhydrous tin(II) chloride and is commercially available. (wikipedia.org)
Me3Si)2N]2S is prepared by the reaction of lithium bis(trimethylsilyl)amide and sulfur dichloride (SCl2). (wikipedia.org)
The latter compound is a metal bis(trimethylsilyl)amide and can be synthesized by the reaction of selenium tetrachloride (SeCl4), selenium monochloride (Se 2Cl 2) and lithium bis(trimethylsilyl)amide. (wikipedia.org)
American Elements manufactures potassium bis(trimethylsilyl)amide solution in various concentrations and organic solvents such as THF, toulene, 2-methyltetrahydrofuran, and tert-butyl ether. (americanelements.com)

Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and they are more stable and soluble than the other alkali metal analogs. (wikipedia.org)
Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by reaction of the amine with potassium, potassium hydride, n-butylpotassium, or benzylpotassium. (wikipedia.org)
Amide can also refer to azanide (the anion H 2 N − , conjugate base of ammonia ) or to an organic amine (an anion R 2 N − ). For discussion of these " anionic amides", see Alkali metal amides . (wikipedia.org)
When the amide is derived from a primary or secondary amine, the substituents on nitrogen are indicated first in the name. (wikipedia.org)

Metal Amide Chemistry. (wikipedia.org)
An amide ion is different from an amide in organic chemistry. (wikipedia.org)

Amide ligands have two electron pairs available for bonding. (wikipedia.org)
In these two examples, the dimethylamido ligands are both bridging and terminal: Tris(dimethylamino)aluminium dimer Tris(dimethylamino)gallium dimer In practice, bulky amide ligands have a lesser tendency to bridge. (wikipedia.org)
Amide ligands may participate in metal-ligand π-bonding giving a complex with the metal center being co-planar with the nitrogen and substituents. (wikipedia.org)
The methyleneamino and hydroxyethylene replacements, which have been used elsewhere as transition-state inhibitors of enzymes, are poor mimics of the amide in these CCK-B receptor ligands. (nih.gov)
Amides and hydroxamic acids derived from α-amino acids were evaluated as ligands in combination with rhodium and iridium half-sandwich complexes in asymmetric transfer hydrogenation (ATH) of ketones. (diva-portal.org)

article{369f354d-3b18-4890-a9c0-a314ba490cb6, abstract = {Let's do the twist: The first twisted bis-amide is obtained by the benzylic oxidation of Tröger's base (TB). (lu.se)

A series of amides were investigated as potential bioisosteres of previously reported triazole oxytocin antagonists. (nih.gov)

Note: As the nomenclature of amides of sulfur acids is described (though less extensively) in Rule C-641.8 , the present Subsection is illustrated mostly for carbon acids. (acdlabs.com)

Sterically hindered substrates can be converted with s -BuLi/TMEDA at -90 C. The amides can be efficiently reduced with lithium aluminum hydride to the corresponding Mannich bases. (organic-chemistry.org)
The proposed methodology readily affords the production of pure lithium amide nanoparticles at both bench-top and commercial scale. (wiley.com)
Miyaoka H, Wang Y, Hino S, Isobe S, Tokoyoda K, Ichikawa T, Kojima Y. Kinetic Modification on Hydrogen Desorption of Lithium Hydride and Magnesium Amide System. (mdpi.com)
This report is a professional and in-depth study on the current state of the Lithium Amide industry. (prsync.com)
The Lithium Amide market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. (prsync.com)
Lithium Amide industry import/export consumption, supply and demand figures and cost price and production value gross margins are also provided. (prsync.com)
The Lithium Amide industry development trends and marketing channels are analyzed. (prsync.com)
1] in 2002 found that lithium-nitride reversibly absorbs a large amount of hydrogen and form a mixture of lithium-hydride and lithium-amide. (uio.no)

2. An absorbable stent formed of a material comprising a copolymer, wherein the copolymer comprises a poly(ester amide) block and a tyrosine di-peptide block. (google.com.au)
Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. (anaspec.com)
The first member of the RF-amide peptide superfamily to be characterized, in 1977, was the cardioexcitatory peptide, FMRFamide, isolated from the ganglia of the clam Macrocallista nimbosa ( 1 ). (frontiersin.org)
The discovery, 12 years ago, that the RF-amide peptide kisspeptin, acting via GPR54, was essential for the onset of puberty and reproduction, has been a major breakthrough in reproductive physiology ( 2 - 4 ). (frontiersin.org)
Comparative studies on non-mammalian vertebrates and invertebrates allow major advances in the knowledge of the evolutionary history of the RF-amide peptide superfamily. (frontiersin.org)
They thus report that kisspeptin should be classified in the galanin/spexin family rather than in the RF-amide peptide family. (frontiersin.org)
As indicated above, the characterization of the first RF-amide peptide was carried out in a mollusk. (frontiersin.org)
Spectroscopic and chemical evidence reveals that the drug interacts noncovalently with its receptor, suggesting that the alpha-keto amid of FK506 serves as a surrogate for the twisted amide of a bound peptide substrate. (sciencemag.org)

The ensemble is generally represented as RC(O)NH 2 and is described as a primary amide. (wikipedia.org)
Primary amide is the one that has a nitrogen atom that is bonded to two hydrogen atoms. (bartleby.com)

This thesis presents density functional theory calculations performed on Mg(NH2)2 (magnesium-amide). (uio.no)

Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. (google.com.au)
This invention generally relates to poly(ester amide) block copolymers useful for forming a bioabsorbable device such as a stent or for coating an implantable device such as a drug-delivery stent. (google.com.au)

N- substituted primary and secondary amides may also be described as acylamines or, more specifically as monoacylamines and diacylamines, respectively. (acdlabs.com)
Classify each of the amides in Problem 17-101 as a primary, secondary, or tertiary amide. (bartleby.com)
Given amide has to be classified as primary, secondary, or tertiary amide. (bartleby.com)
Amides are also classified as primary, secondary, and tertiary amide. (bartleby.com)
Secondary amide is the one that has a nitrogen atom that is bonded to one hydrogen atom and one alkyl (or aryl) group. (bartleby.com)
Secondary amides are also known as monosubstituted amides. (bartleby.com)
Tris(pentafluorophenyl)boron B(C 6 F 5 ) 3 is an effective catalyst for the reduction of tertiary and N -phenyl secondary amides in the presence of a silane. (organic-chemistry.org)
A chemoselective activation of a secondary amide with triflic anhydride in the presence of 2-fluoropyridine enables a mild reduction using triethylsilane, a cheap and rather inert reagent. (organic-chemistry.org)

Most common are carboxamides (organic amides) ( n = 1, E = C, x = 1), but many other important types of amides are known, including phosphoramides ( n = 2, E = P, x = 1 and many related formulas) and sulfonamides (E = S, x = 2). (wikipedia.org)

Phenol carbamates undergo an anionic ortho -Fries rearrangement to their corresponding amides in the presence of LDA. (organic-chemistry.org)

The angle between the two Gly 79 amide-I transition dipoles, estimated at 103° from linear IR spectroscopy and 110° from 2D IR spectroscopy, combined with the coupling led to a structural picture of the hydrophobic interface that is remarkably consistent with results from NMR on helix dimers. (pnas.org)

A certain class of poly(ester-amide) polymers are disclosed which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (google.com.au)
The particular class of poly(ester-amides) are those which include a polymeric fat. (google.com.au)
This invention relates to a certain class of poly(ester-amide) polymers which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (google.com.au)
Poly(ester-amide) adhesive compositions have been known for some time in the art, including the use as hot melt adhesives for various substrates such as metals, wood and plastics. (google.com.au)
Included in this background of poly(ester-amide) compositions are U.S. Pats. (google.com.au)
No. 3,650,999, related to poly(ester-amide) compositions, is generally useful as adhesives to a variety of substrates such as steel, aluminum, wood and plastic substrates. (google.com.au)
By the proper selection of reactants and using special polymerization techniques, a block copolymer poly(ester-amide) composition was prepared having certain advantages in high temperature properties over earlier adhesive compositions. (google.com.au)
Once the ester is in hand than the amides are straight forward to prepare. (github.com)

The remainder of this article is about the carbonyl - nitrogen sense of amide . (wikipedia.org)
Consequently, the nitrogen in amides is not pyramidal. (wikipedia.org)
One final thing to note when looking at the bonds of an amide is that there is also a hydrogen bond present between the active groups hydrogen and nitrogen atoms. (wikipedia.org)

The amide linkage is found in many useful synthetic polymers such as nylon. (gsu.edu)
The high synthetic accessibility of this new amide series also facilitated the identification of a range of alternative left hand side (biaryl replacement) substituents which gave good levels of oxytocin antagonism. (nih.gov)
I've come up with a synthetic route to amide-substituted triazolopyrazines - what do you think? (github.com)

The study revealed that the itaconyl m-phenylene amide polymer was a weak antioxidant, while itaconyl bisaniline- and itaconyl-o-tolidine amide polymers showed good anti-oxidation property. (ingentaconnect.com)
Croda Polymer Additives has announced plans to invest in the expansion of its amide capacity at their manufacturing site in Hull, United Kingdom. (croda.com)

Transition metal amides are intermediates in the base-induced substitution of transition metal ammine complexes. (wikipedia.org)
Thus, the desired bisheterocyclo methanide and amide complexes should achieve the best from two worlds: the stabilisation abilities for future low-valent metal complexes and the reactivity of group 13 metals. (weltbild.de)

This application demonstrates the suitability of the Ascentis RP-Amide for the analysis of the pesticides carbaryl, diuron, and propachlor, utilizing isocratic conditions and UV detection. (environmental-expert.com)
No comments were found for Ascentis™ RP-Amide for the Analysis of Pesticides . (environmental-expert.com)

Twisted Amide Analogues of Tröger's Base. (lu.se)

The present invention relates to a method for the manufacture of amides from the corresponding nitrile using a biocatalyst that is a microorganism capable of producing a nitrile hydratase enzyme. (freepatentsonline.com)

The improved methods for the reduction of nitriles 1 and amides 2 with complex metal hydrides have been so far reported. (erowid.org)

These peptides increase tension of the pedal retractor muscle and, in conjunction with FMRF-amide, increase peak tension of the anterior byssus retractor muscle (ABRM). (uniprot.org)
It has also put in front of the spotlights RF-amide peptides and has invigorated research on this superfamily of regulatory neuropeptides. (frontiersin.org)
The present Research Topic aims at illustrating major advances achieved, through comparative studies in (mammalian and non-mammalian) vertebrates and invertebrates, in the knowledge of RF-amide peptides in terms of evolutionary history and physiological significance. (frontiersin.org)
Use of Pico-Tag methodology in the chemical analysis of peptides with carboxyl-terminal amides. (biomedsearch.com)

Identification of amide bioisosteres of triazole oxytocin antagonists. (nih.gov)
Vasopressin (-Leu-Gly-amide), oxytocin (-Gly-amide), Lys1 gamma 1-melanotropin (-Phe-amide), and various acetylated and non-acetylated forms of alpha-melanotropin (-Val-amide) were identified in the posterior pituitary extract. (biomedsearch.com)

SABRE is used to hyperpolarize the transfer agent NH 2 R, where R is H or CH 2 Ph or CH 2 CH 2 Ph (etc.), which relays polarization to the analyte (HR″, route A), and R″ is amide, carboxyl, phosphate, or alkoxide (etc. (sciencemag.org)

Amides are formed when amino acids react to form proteins . (gsu.edu)

Organisms1

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes23

Disciplines and Occupations2

Information Science2

Health Care1

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

Amides

Amidohydrolases

Amide Synthases

Glucagon-Like Peptides

Polyunsaturated Alkamides

Endocannabinoids

Magnetic Resonance Spectroscopy

Molecular Structure

Deuterium Exchange Measurement

Carbamates

Spectrophotometry, Infrared

Spectroscopy, Fourier Transform Infrared

Hydrogen

Models, Molecular

Cannabinoid Receptor Modulators

Deuterium

Arachidonic Acids

Glucagon-Like Peptide 1

Protein Conformation

Hydrogen Bonding

Structure-Activity Relationship

Stereoisomerism

Amino Acid Sequence

Peptides

Protein Structure, Secondary

Molecular Sequence Data

Monoacylglycerol Lipases

Protons

Nitrogen Isotopes

Nuclear Magnetic Resonance, Biomolecular

Kinetics

Molecular Conformation

Receptor, Cannabinoid, CB1

Peptide Fragments

Esters

Hydrolysis

Oligopeptides

Substrate Specificity

Mass Spectrometry

Receptors, Glucagon

Hydrogen-Ion Concentration

Catalysis

Lanthanoid Series Elements

Glucagon

Models, Chemical

Binding Sites

Dipeptides

Water

Carboxylic Acids

Circular Dichroism

Receptors, Cannabinoid

Thermodynamics

Crystallography, X-Ray

Amines

Deuterium Oxide

Solvents

Chromatography, High Pressure Liquid

Peptoids

Benzamides

Magainins

Spectrum Analysis, Raman

Protein Folding

Solutions

Pyrrolidonecarboxylic Acid

Glutamine

Spectrometry, Mass, Fast Atom Bombardment

Drug Design

Asparagine

Acylation

Ethanolamines

Oleic Acids

Protein Binding

Cyclization

Enzyme Inhibitors

Temperature

Piperidines

Receptor, Cannabinoid, CB2

Cannabinoids

Spectrometry, Mass, Electrospray Ionization

Benzodioxoles