Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)AmidohydrolasesAmide Synthases: Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.Glucagon-Like Peptides: Peptides derived from proglucagon which is also the precursor of pancreatic GLUCAGON. Despite expression of proglucagon in multiple tissues, the major production site of glucagon-like peptides (GLPs) is the INTESTINAL L CELLS. GLPs include glucagon-like peptide 1, glucagon-like peptide 2, and the various truncated forms.Polyunsaturated Alkamides: Amides composed of unsaturated aliphatic FATTY ACIDS linked with AMINES by an amide bond. They are most prominent in ASTERACEAE; PIPERACEAE; and RUTACEAE; and also found in ARISTOLOCHIACEAE; BRASSICACEAE; CONVOLVULACEAE; EUPHORBIACEAE; MENISPERMACEAE; POACEAE; and SOLANACEAE. They are recognized by their pungent taste and for causing numbing and salivation.Endocannabinoids: Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Deuterium Exchange Measurement: A research technique to measure solvent exposed regions of molecules that is used to provide insight about PROTEIN CONFORMATION.Carbamates: Derivatives of carbamic acid, H2NC(=O)OH. Included under this heading are N-substituted and O-substituted carbamic acids. In general carbamate esters are referred to as urethanes, and polymers that include repeating units of carbamate are referred to as POLYURETHANES. Note however that polyurethanes are derived from the polymerization of ISOCYANATES and the singular term URETHANE refers to the ethyl ester of carbamic acid.Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Cannabinoid Receptor Modulators: Compounds that interact with and modulate the activity of CANNABINOID RECEPTORS.Deuterium: Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.Arachidonic AcidsGlucagon-Like Peptide 1: A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Monoacylglycerol Lipases: An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23.Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.Nitrogen Isotopes: Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Kinetics: The rate dynamics in chemical or physical systems.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Receptor, Cannabinoid, CB1: A subclass of cannabinoid receptor found primarily on central and peripheral NEURONS where it may play a role modulating NEUROTRANSMITTER release.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.EstersHydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Oligopeptides: Peptides composed of between two and twelve amino acids.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Receptors, Glucagon: Cell surface receptors that bind glucagon with high affinity and trigger intracellular changes which influence the behavior of cells. Activation of glucagon receptors causes a variety of effects; the best understood is the initiation of a complex enzymatic cascade in the liver which ultimately increases the availability of glucose to body organs.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Lanthanoid Series Elements: Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Dipeptides: Peptides composed of two amino acid units.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Receptors, Cannabinoid: A class of G-protein-coupled receptors that are specific for CANNABINOIDS such as those derived from CANNABIS. They also bind a structurally distinct class of endogenous factors referred to as ENDOCANNABINOIDS. The receptor class may play a role in modulating the release of signaling molecules such as NEUROTRANSMITTERS and CYTOKINES.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Peptoids: Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.Benzamides: BENZOIC ACID amides.Magainins: A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.Spectrum Analysis, Raman: Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.Spectrometry, Mass, Fast Atom Bombardment: A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Acylation: The addition of an organic acid radical into a molecule.Ethanolamines: AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.Oleic Acids: A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Piperidines: A family of hexahydropyridines.Receptor, Cannabinoid, CB2: A subclass of cannabinoid receptor found primarily on immune cells where it may play a role modulating release of CYTOKINES.Cannabinoids: Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Benzodioxoles: Compounds based on benzene fused to oxole. They can be formed from methylated CATECHOLS such as EUGENOL.Nitrogenous Group Transferases: Enzymes that catalyze the transfer of nitrogenous groups, primarily amino groups, from a donor, generally an amino acid, to an acceptor, usually a 2-oxoacid. EC 2.6.Glycerides: GLYCEROL esterified with FATTY ACIDS.Peptide PHI: A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.Coumarins: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Heterocyclic Compounds: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)Cannabinoid Receptor Antagonists: Compounds that inhibit or block the activity of CANNABINOID RECEPTORS.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Palmitic Acids: A group of 16-carbon fatty acids that contain no double bonds.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Thioamides: Organic compounds containing the radical -CSNH2.

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides. (1/3261)

The NADP-specific glutamate dehydrogenase of Neurospora crassa was digested with trypsin, and peptides accounting for 441 out of the 452 residues of the polypeptide chain were isolated and substantially sequenced. Additional experimental detail has been deposited as Supplementary Publication SUP 50052 (11 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem J. (1975) 145, 5.  (+info)

Transformation mediated by RhoA requires activity of ROCK kinases. (2/3261)

BACKGROUND: The Ras-related GTPase RhoA controls signalling processes required for cytoskeletal reorganisation, transcriptional regulation, and transformation. The ability of RhoA mutants to transform cells correlates not with transcription but with their ability to bind ROCK-I, an effector kinase involved in cytoskeletal reorganisation. We used a recently developed specific ROCK inhibitor, Y-27632, and ROCK truncation mutants to investigate the role of ROCK kinases in transcriptional activation and transformation. RESULTS: In NIH3T3 cells, Y-27632 did not prevent the activation of serum response factor, transcription of c-fos or cell cycle re-entry following serum stimulation. Repeated treatment of NIH3T3 cells with Y-27632, however, substantially disrupted their actin fibre network but did not affect their growth rate. Y-27632 blocked focus formation by RhoA and its guanine-nucleotide exchange factors Dbl and mNET1. It did not affect the growth rate of cells transformed by Dbl and mNET1, but restored normal growth control at confluence and prevented their growth in soft agar. Y-27632 also significantly inhibited focus formation by Ras, but had no effect on the establishment or maintenance of transformation by Src. Furthermore, it significantly inhibited anchorage-independent growth of two out of four colorectal tumour cell lines. Consistent with these data, a truncated ROCK derivative exhibited weak ability to cooperate with activated Raf in focus formation assays. CONCLUSIONS: ROCK signalling is required for both the establishment and maintenance of transformation by constitutive activation of RhoA, and contributes to the Ras-transformed phenotype. These observations provide a potential explanation for the requirement for Rho in Ras-mediated transformation. Moreover, the inhibition of ROCK kinases may be of therapeutic use.  (+info)

The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. Peptic and chymotryptic peptides and the complete sequence. (3/3261)

Peptic and chymotryptic peptides were isolated form the NADP-specific glutamate dehydrogenase of Neurospora crassa and substantially sequenced. Out of 452 residues in the polypeptide chain, 265 were recovered in the peptic and 427 in the chymotryptic peptides. Together with the tryptic peptides [Wootton, J. C., Taylor, J. G., Jackson, A. A., Chambers, G. K. & Fincham, J. R. S. (1975) Biochem. J. 149, 749-755], these establish the complete sequence of the chain, including the acid and amide assignments, except for seven places where overlaps are inadequate. These remaining alignments are deduced from information on the CNBr fragments obtained in another laboratory [Blumenthal, K. M., Moon, K. & Smith, E. L. (1975), J. Biol. Chem. 250, 3644-3654]. Further information has been deposited as Supplementary Publication SUP 50054 (17 pages) with the British Library (Lending Division), Boston Spa, Wetherby, W. Yorkshire LS23 7BQ, U.K., from whom copies may be obtained under the terms given in Biochem. J. (1975) 145, 5.  (+info)

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. (4/3261)

An extensive loss of a selected population of neurons in Alzheimer's disease is closely related to the formation of paired helical filaments (PHFs). The most striking characteristic of PHFs upon Western blotting is their smearing. According to a previously described protocol (Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Titani, K., and Ihara, Y. (1993) Neuron 10, 1151-1160), smeared tau was purified, and its peptide map was compared with that of soluble (normal) tau. A CNBr fragment from soluble tau (CN5; residues 251-419 according to the 441-residue isoform) containing the microtubule-binding domain migrated at 15 and 18 kDa on SDS-polyacrylamide gel electrophoresis, whereas that from smeared tau exhibited two larger, unusually broad bands at approximately 30 and approximately 45 kDa, presumably representing dimers and trimers of CN5. In the peptide map of smeared tau-derived CN5, distinct peaks eluting at unusual locations were noted. Amino acid sequence and mass spectrometric analyses revealed that these distinct peptides bear isoaspartate at Asn-381 and Asp-387. Because no unusual peptides other than aspartyl or isoaspartyl peptide were found in the digests of smeared tau-derived CN5, it is likely that site-specific deamidation and isoaspartate formation are involved in its dimerization and trimerization and thus in PHF formation in vivo.  (+info)

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. (5/3261)

1. We have studied the modulation of volume-regulated anion channels (VRACs) by the small GTPase Rho and by one of its targets, Rho kinase, in calf pulmonary artery endothelial (CPAE) cells. 2. RT-PCR and immunoblot analysis showed that both RhoA and Rho kinase are expressed in CPAE cells. 3. ICl,swell, the chloride current through VRACs, was activated by challenging CPAE cells with a 25 % hypotonic extracellular solution (HTS) or by intracellular perfusion with a pipette solution containing 100 microM GTPgammaS. 4. Pretreatment of CPAE cells with the Clostridium C2IN-C3 fusion toxin, which inactivates Rho by ADP ribosylation, significantly impaired the activation of ICl,swell in response to the HTS. The current density at +100 mV was 49 +/- 13 pA pF-1 (n = 17) in pretreated cells compared with 172 +/- 17 pA pF-1 (n = 21) in control cells. 5. The volume-independent activation of ICl,swell by intracellular perfusion with GTPgammaS was also impaired in C2IN-C3-pretreated cells (31 +/- 7 pA pF-1, n = 11) compared with non-treated cells (132 +/- 21 pA pF-1, n = 15). 6. Activation of ICl,swell was pertussis toxin (PTX) insensitive. 7. Y-27632, a blocker of Rho kinase, inhibited ICl,swell and delayed its activation. 8. Inhibition of Rho and of Rho kinase by the above-described treatments did not affect the extent of cell swelling in response to HTS. 9. These experiments provide strong evidence that the Rho-Rho kinase pathway is involved in the VRAC activation cascade.  (+info)

Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. (6/3261)

The role of a Rho-associated coiled-coil forming kinase in migration of neutrophils has been investigated. Rho-associated coiled-coil forming kinase I was expressed in human neutrophils. Chemotactic peptide led to a Rho-associated coiled-coil forming kinase-dependent increase in phosphorylation of myosin light chain. This was determined with the help of an antibody directed against serine 19-phosphorylated myosin light chain and an inhibitor of Rho-associated coiled-coil forming kinase (Y-27632). Y-27632 suppressed myosin light chain phosphorylation and chemotactic peptide-induced development of cell polarity and locomotion with similar potency (ED50 0.5-1.1 microM). The data strongly suggest that a Rho-associated coiled-coil forming kinase isoform, activated in human neutrophils exposed to chemotactic peptide, is important for motile functions of these cells.  (+info)

Determination of the lipophilicity of active anticonvulsant N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid. (7/3261)

The lipophilicities of fourteen anticonvulsant active N-substituted amides of alpha-arylalkylamine-gamma-hydroxybutyric acid [I-XIV] have been determined by reversed-phase thin-layer chromatography with a mixture of methanol, TRIS buffer, and acetic acid as the solvent system. The RM value of each compound decreased linearly with increasing concentration of methanol. The partition coefficients (log P) of the amides were calculated by use of the Prolog P module of the Pallas system. Comparison of RM and log P enabled clog P values to be calculated. It was found that the anticonvulsant activity of amides [I-XIV] can be explained on the basis of their lipophilicity.  (+info)

Comparison of three solutions of ropivacaine/fentanyl for postoperative patient-controlled epidural analgesia. (8/3261)

BACKGROUND: Ropivacaine, 0.2%, is a new local anesthetic approved for epidural analgesia. The addition of 4 microg/ml fentanyl improves analgesia from epidural ropivacaine. Use of a lower concentration of ropivacaine-fentanyl may further improve analgesia or decrease side effects. METHODS: Thirty patients undergoing lower abdominal surgery were randomized in a double-blinded manner to receive one of three solutions: 0.2% ropivacaine-4 microg fentanyl 0.1% ropivacaine-2 microg fentanyl, or 0.05% ropivacaine-1 microg fentanyl for patient-controlled epidural analgesia after standardized combined epidural and general anesthesia. Patient-controlled epidural analgesia settings and adjustments for the three solutions were standardized to deliver equivalent drug doses. Pain scores (rest, cough, and ambulation), side effects (nausea, pruritus, sedation, motor block, hypotension, and orthostasis), and patient-controlled epidural analgesia consumption were measured for 48 h. RESULTS: All three solutions produced equivalent analgesia. Motor block was significantly more common (30 vs. 0%) and more intense with the 0.2% ropivacaine-4 microg fentanyl solution. Other side effects were equivalent between solutions and mild in severity. A significantly smaller volume of 0.2% ropivacaine-4 microg fentanyl solution was used, whereas the 0.1% ropivacaine-2 microg fentanyl group used a significantly greater amount of ropivacaine and fentanyl. CONCLUSIONS: Lesser concentrations of ropivacaine and fentanyl provide comparable analgesia with less motor block despite the use of similar amounts of ropivacaine and fentanyl. This finding suggests that concentration of local anesthetic solution at low doses is a primary determinant of motor block with patient-controlled epidural analgesia after lower abdominal surgery.  (+info)

*Glucagon-like peptide 1 receptor

1994). "Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes". Digestion. ...

*Palmitoylethanolamide

PEA, as well as its analogue adelmidrol (di-amide derivative of azelaic acid), can both down-regulate mast cells. PEA reduces ... Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been ... Calignano a, L. R. G. (2001). "Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide". Eur J ... Costa, B.; Comelli, F.; Bettoni, I.; Colleoni, M.; Giagnoni, G. (2008). "The endogenous fatty acid amide, palmitoylethanolamide ...

*Protein primary structure

This intermediate tends to revert to the amide form, expelling the attacking group, since the amide form is usually favored by ... Sugar moieties can be attached to the sidechain hydroxyl groups of Ser/Thr or to the sidechain amide groups of Asn. Such ... It is attached to the polypeptide C-terminus through an amide linkage that then connects to ethanolamine, thence to sundry ... For completeness, the proposal that proteins contained amide linkages was made as early as 1882 by the French chemist E. ...

*Chiral auxiliary

One primary advantage of asymmetric alkylation with pseudoephedrine amides is that the amide enolates are typically ... Pseudoephedrine amides are typically prepared by acylation with an acid chloride or acid anhydride. Acylation of (S,S)- ... Pseudoephedrine amides undergo deprotonation by a strong base such as lithium diisopropylamide (LDA) to give the corresponding ... Transformation of pseudoephedrine amides into synthetically useful functional groups. After cleavage, the auxiliary can be ...

*Metal amides

... are a class of coordination compounds composed of a metal center with amide ligands of the form NR2. Amide ligands ... Lithium amides are the most important amides, as they are readily prepared from n-butyllithium and the appropriate amine, and ... The alkali metal amides, MNH2 (M = Li, Na, K) are commercially available. Sodium amide (also known as sodamide) is synthesized ... Potassium amides are prepared by transmetallation of lithium amides with potassium t-butoxide (see also Schlosser base) or by ...

*Metal bis(trimethylsilyl)amides

... amide ligands and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis( ... Cage Complexes of N-Heterocyclic Amide and Bis(trimethylsilyl)amide Ligands: Synthesis, Structure, and Magnetic Properties". ... Metal bis(trimethylsilyl)amides are strong bases. They are corrosive, and are incompatible with many chlorinated solvents. ... Bunge, Scott D.; Just, Oliver; Rees, William S. Jr (2000). "[{Au[μ-N(SiMe3)2]}4]: The First Base-Free Gold Amide". Angewandte ...

*Amide

In primary and secondary amides, the presence of N-H dipoles allows amides to function as H-bond donors as well. Thus amides ... see Alkali metal amides. The remainder of this article is about the carbonyl-nitrogen sense of amide. The simplest amides are ... An amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 ( ... Amides undergo many chemical reactions, although they are less reactive than esters. Amides hydrolyse in hot alkali as well as ...

*Amide reduction

... is a reaction in organic synthesis where an amide is reduced to either an amine or an aldehyde functional group ... Some amides can be reduced to aldehydes in the Sonn-Müller method. A well known method for amide reduction is hydrosilylation ... N-disubstituted amides can be reduced to aldehydes by using an excess of the amide:[citation needed] R(CO)NRR' + LiAlH4 → RCHO ... Zhou, S.; Junge, K.; Addis, D.; Das, S.; Beller, M. (2009). "A Convenient and General Iron-Catalyzed Reduction of Amides to ...

*Lithium amide

The anionic conjugate bases of amines are known as amides. Thus a lithium amide may also refer to any compound in the class of ... Lithium amide can be made by adding lithium metal to liquid ammonia: 2Li + 2NH3 → 2LiNH2 + H2 Lithium amides in general can be ... Lithium amide is an inorganic compound with the chemical formula Li+NH2−, i.e. it is composed of a lithium cation, and the ... Sodium amide Butyllithium M.F. Lappert; M.J. Slade; A. Singh; J.L. Atwood; R.D. Rogers; R. Shakir (1983). "Structure and ...

*Sodium amide

As such, sodium amide is to be stored in a tightly closed container, under an atmosphere of an inert gas. Sodium amide samples ... Sodium amide can be prepared by the reaction of sodium with ammonia gas, but it is usually prepared by the reaction in liquid ... Sodium amide is mainly used as a strong base in organic chemistry, often in liquid ammonia solution. It is the reagent of ... Sodium amide induces the loss of two equivalents of hydrogen bromide from a vicinal dibromoalkane to give a carbon-carbon ...

*Amide ring

... in such structures a 9-atom amide ring occurs between the amide side chain of the pentapeptide's asparagine and the main chain ... Amide Rings are small motifs in proteins and polypeptides. They consist of 9-atom or 11-atom rings formed by two CO...HN ... An amide ring is employed in the specificity of the adaptor protein GRB2 for a particular asparagine within proteins it binds. ... An 11-atom amide ring, involving a glutamine residue, occurs at the interior of the light chain variable domains of some ...

*Potassium amide

Alternatively, it can be produced by the reaction of potassium oxide with liquid ammonia at -50 °C. Sodium amide Lithium amide ... Potassium amide is an inorganic compound with the chemical formula KNH2, i.e. it is composed of a potassium cation, and the ... Potassium amide is produced by the reaction of gaseous ammonia with metallic potassium. ...

*Dansyl amide

... is a reactive fluorescent dye that is used in biochemistry and chemistry to label substances with the fluorescent ...

*Amide group

... may refer to: Amide, an organic functional group characterized by a carbonyl group linked to a nitrogen atom, or a ...

*Fatty acid amide

Fatty acid amides (FAAs) are amides formed from a fatty acid and an amine. In nature, many FAAs have ethanolamine as the amine ... Other fatty acid amides are fatty acid primary amides (FAPAs). They contain the functionality RC(O)NH2). Oleamide is an example ... The signalling is controlled in part by fatty acid amide hydrolases, which convert the amide to the parent fatty acid. One ... Aliphatic amides can be found in Zanthoxylum species found in Nigeria. Fatty acid ester McKinney, Michele K.; Cravatt, Benjamin ...

*Glutathione amide reductase

... (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD+ oxidoreductase. This ... glutathione amide disulfide + NADH + H+ Glutathione amide reductase is a dimeric flavoprotein (FAD). Vergauwen, B.; Pauwels, F ... Glutathione amide reductase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". J. Biol. Chem. 276: 20890- ...

*Lithium bis(trimethylsilyl)amide

MXx + x Li(hmds) → M(hmds)x + x LiX (X = Cl, Br, I and sometimes F) Metal bis(trimethylsilyl)amide complexes are lipophilic due ... Lithium bis(trimethylsilyl)amide is a lithiated organosilicon compound with the formula LiN(SiMe3)2. It is commonly abbreviated ... Lithium amide Lithium diisopropylamide Lithium tetramethylpiperidide Amonoo-Neizer, E. H.; Shaw, R. A.; Skovlin, D. O.; Smith, ... LiHMDS can react with a wide range of metal halides, via a salt metathesis reaction, to give metal bis(trimethylsilyl)amides. ...

*Sodium bis(trimethylsilyl)amide

Metal bis(trimethylsilyl)amides Watson, B. T.; Lebel, H. "Sodium bis(trimethylsilyl)amide" in Encyclopedia of Reagents for ... Sodium bis(trimethylsilyl)amide is the organosilicon compound with the formula ((CH3)3Si)2NNa. This species, usually called ... amide". Organometallics. 16 (23): 5108-5112. doi:10.1021/om970444c. Sergey A. Kozmin, Shuwen He, and Viresh H. Rawal. " ...

*Fatty acid amide hydrolase

Patricelli MP, Cravatt BF (October 1999). "Fatty acid amide hydrolase competitively degrades bioactive amides and esters ... Fatty acid amide hydrolase or FAAH (EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) is a member of the serine ... fatty-acid amide hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH) Proteopedia FAAH entry - ... In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of ...

*Potassium bis(trimethylsilyl)amide

Metal bis(trimethylsilyl)amides Potassium bis(trimethylsilyl)amide, Sigma-Aldrich Tesh, Kris F.; Hanusa, Timothy P.; Huffman, ... Potassium bis(trimethylsilyl)amide (commonly abbreviated as KHMDS, Potassium(K) HexaMethylDiSilazide) is the chemical compound ...

*Von Braun amide degradation

The von Braun amide degradation is the chemical reaction of a monosubstituted amide with phosphorus pentachloride or thionyl ... B. A. Phillips, G. Fodor, J. Gal, F. Letourneau and J. J. Ryan (1973). "Mechanism of the von Braun amide degradations with ...

*Glutathione amide-dependent peroxidase

... (EC 1.11.1.17) is an enzyme with systematic name glutathione amide:hydrogen-peroxide ... Glutathione amide-dependent peroxidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". J. Biol. Chem. 276 (24): 20890 ... This enzyme catalyses the following chemical reaction 2 glutathione amide + H2O2 ⇌ {\displaystyle \rightleftharpoons } ...

*L-proline amide hydrolase

... at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology ... L-proline amide hydrolase (EC 3.5.1.101, S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase, LaaA, L-amino acid ...

*N-acylethanolamine acid amide hydrolase

... (NAAA) is a member of the choloylglycine hydrolase family, a subset of the N-terminal ... While NAAA operates much like fatty acid amide hydrolase (FAAH), the two enzymes do not share a homology. It does have 30% ... NAAA cleaves C-N non-peptide bonds in linear amides, particularly ethanolamides. Its mechanism is quite similar to that of AC, ... and functional similarity to fatty acid amide hydrolase (FAAH) allow it to be studied extensively. The overall enzyme mechanism ...

*Lysergic acid 3-pentyl amide

Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. Journal of Medicinal ... Lysergic acid 3-pentyl amide (3-Pentyllysergamide, LSP) is an analogue of LSD originally researched by David E. Nichols and ... Lysergic acid 2-butyl amide Methylisopropyllysergamide David E. Nichols. LSD and Its Lysergamide Cousins. The Heffter Review of ...
An efficient amide bond formation through the rapid and strong activation of carboxylic acids in a micro-flow reactorAn efficient amide bond formation through the rapid and strong activation of carboxylic acids in a micro-flow reactor ...
This thesis deals with the development and application of new synthetic methodology in organic chemistry.. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. In addition, this methodology is implemented as a key-step in a formal total synthesis of the antibiotic (-)-anisomycin.. In the second part, a new methodology for the synthesis of arylglycines from Weinreb amides is described. In this procedure, a Grignard reagent is added to the iminium ion formed from the Weinreb amide upon treatment with a base. When a chiral amide is used, the nucleophilic addition proceeds with high diastereoselectivity.. Finally, an easy and straightforward synthesis of α-amino amides via a base-mediated rearrangement of modified Weinreb amides into N,O-acetals is presented. Subsequent arylation, alkylation, alkenylation or alkynylation of this intermediate affords the corresponding α-amino ...
The molecular mechanisms conferring high resistance of planar tertiary amide bonds to hydrolysis by most enzymes have remained elusive. To provide a chemical explanation to this unresolved puzzle, UB3LYP calculations were performed on an active site model of Xaa-Pro peptidases. The calculated reaction mechanism demonstrates that biocatalysts capable of tertiary amide bond hydrolysis capitalize on anti nucleophilic attack and protonation of the amide nitrogen, in contrast to the traditional syn displayed by amidases and proteases acting on secondary amide bonds.. ...
As part of a continuing search for new potential anticancer candidates, we describe the synthesis, cytotoxicity and mechanistic evaluation of a series of 4-oxoquinoline-3-carboxamide derivatives as novel anticancer agents. The inhibitory activity of compounds 10-18 was determined against three cancer cell lines using the MTT colorimetric assay. The screening revealed that derivatives 16b and 17b exhibited significant cytotoxic activity against the gastric cancer cell line but was not active against a normal cell line, in contrast to doxorubicin, a standard chemotherapeutic drug in clinical use. Interestingly, no hemolytical activity was observed when the toxicity of 16b and 17b was tested against blood cells. The in silico and in vitro mechanistic evaluation indicated the potential of 16b as a lead for the development of novel anticancer agents against gastric cancer cells.
In this application, Dr Claudio Battilocchio of the Ley group, University of Cambridge, has used Vapourtecs 20 ml Rapid Mixing Reactors to perform an amide synthesis under biphasic flow reaction conditions.
The resins contain 5-10% non cleavable covalently attached ligands, 40 - 45% linker for peptide amide release at low concentrated TFA (5%) and 40 - 45% linker for peptide amide release with 95% TFA. The peptide, liberated by 5% TFA treatment must be seperated from the resin and deprotected with 95% TFA in a follow up step. This resin type is designed for screening of peptide amide libraries by sequential release. ...
INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - diagram, schematic, and image 86 ...
Shop Chroma Atelier Interactive Artists Acrylics - Arylamide Yellow Light, 250 ml jar at Utrecht. Your source for quality, professional art supplies.
Khoo LPY, Corbett AR.Successful resuscitation of an ASA 3 patient following ropivacaine-induced cardiac arrest. Anaesthesia and Intensive Care 34: 804-807, No. 6, Dec 2006 - AustraliaGoogle Scholar ...
Amides are of fundamental interest in many fields of chemistry involving organic synthesis, chemical biology and biochemistry. Here, we report the first catalytic Buchwald-Hartwig coupling of both common esters and amides by highly selective C(acyl)-X (X = O, N) cleavage to rapidly access aryl amide function
The application of ropivacaine before HTV ventilation reduced Src-pTyr418/Src by 37% compared to HTV alone, however, this effect was not statistically significant (p = 0.678). Acta Anaesthesiol Scand. 2005, 49 (7): 913-918. 10.1111/j.1399-6576.2005.00774.x.View ArticlePubMedGoogle ScholarCostantini R, Affaitati G, Fabrizio A, Giamberardino MA: Controlling pain in the post-operative setting. For some experiments, cells were pretreated for 30minutes with the Src kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d] pyrimidine (PP2; 10μM) dissolved in dimethylsulfoxide (DMSO, Sigma-Aldrich) or with DMSO alone as the vehicle control (0.1%) Effect of ropivacaine on endotoxin-induced changes in expression/phosphorylation of Src, ICAM-1 and caveolin-1 in cultured human lung microvascular endothelial cells (HLMVECs) Ropivacaine blocks LPS-induced Src activation and expression in HLMVECs To Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit ...
Hexanamide. Molecular model of the organic compound and amide hexanamide (C6.H13.N.O), also known as capronamide. This chemical reacts with azo and diazo compounds to generate toxic gases. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), nitrogen (blue) and oxygen (red). Illustration. - Stock Image F016/9786
Provided are: a cyclic amide group-containing polymer having excellent hue, resistance to heat-induced yellowing, and moisture resistance; a cyclic amide acrylate suitable for use as a starting material for the polymer; and a method for producing same. The cyclic amide group-containing polymer is characterized by having a structural unit represented by general formula (1) below. In general formula (1) below, n represents an integer from 1-4, and R1 represents a hydrogen atom, a C1-30 organic group, a metal atom or an ammonium salt.
An amide bond is a peptide bond. It is formed when the amine group of one amino acid forms a bond with the carboxyl group of another amino acid, resulting in the loss of a single water molecule[1]. The peptide group (-CO-NH-) has partial double-bond characteristics due to the resonance of amides, where the nitrogen atom of the amide group is able to donate its lone pair of electrons to the carbon atom in the carboxyl group and push the electrons from the carbonyl C=O double bond towrds the oxygen atom, which forms an oxygen anion[2]. The resonance double bond increases the stability and decreases the rotation about the peptide bond[3]. ...
The structural study of simple amino amides derived from natural amino acids showed a unique conformational pattern for the aromatic residues, being clearly different from that for the aliphatic derivatives. The results from a detailed NMR analysis, supported by DFT calculations, indicate that the aromatic side chain tends to fold over the amino amide moiety, involving a stabilizing polar N-Hπ interaction. The implications of this folding in the establishing of non-covalent interactions is also discussed ...
Women with sonographic uterine artery flow abnormalities and either PE or IUGR (or both) were randomized to either ACET or non ACET control. Both groups were able to receive standard therapies (in-hospital monitoring, magnesium and anti-hypertensives as appropriate). The first five days of the therapeutic arm (ACET) consisted of a dose-finding trial, where epidural ropivacaine infusions (10ml/hr for 24 hours) of 0•04%, 0•06%, 0•08% and 0•1% and a saline placebo were each administered via tunneled epidural catheters in a randomized, double-blinded, cross-over design over five consecutive days; all three women received all doses. Doppler measurement of flow in the uterine artery was performed at baseline and at the end of each dose period. The ideal dose for an individual was determined to be lowest dose of drug giving maximal effect without side effects; in the second stage of the study, this dose was administered until delivery with the addition of a second placebo day to during this ...
Synonyms for acetic amide in Free Thesaurus. Antonyms for acetic amide. 1 synonym for acetamide: ethanamide. What are synonyms for acetic amide?
Here we report the use of a pillaring strategy for the design and synthesis of three novel amide-functionalized metal-organic frameworks (MOFs), TMUs-22/-23/-24, isoreticular to the recently reported imine-functionalized TMU-6 and TMU-21 MOFs. An extensive study of their CO2 sorption properties and selectivity for CO2 over N2, from single gas sorption isotherms to breakthrough measurements, revealed that not only the incorporation of amide groups but also their accessibility is crucial to obtain enhanced CO2 sorption and CO2/N2 selectivity. Therefore, the MOF with more accessible amide groups (TMU-24) shows a CO2/N2 selectivity value of ca. 10 (as revealed by breakthrough experiments), which is ca. 500% and 700% of the selectivity values observed for the other amide-containing (TMU-22 and TMU-23) and imine-containing (TMU-6 and TMU-21) MOFs ...
The amides are a class of organic compounds which can be regarded as having been derived from either acids or amines. For example, the simple aliphati...
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at the rate of 4 mL.hr-1 through two catheters inserted at the lateral edges of the sternum will be studied, versus a control group in which normal saline will be infused in the same conditions ...
3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one: a coupling reagent for mediating amide bond formation with little or no racemization; structure in first source
Valerio, V., Petkova, D., Madelaine, C. and Maulide, N. (2013), Direct Room-Temperature Lactonisation of Alcohols and Ethers onto Amides: An "Amide Strategy" for Synthesis. Chem. Eur. J., 19: 2606-2610. doi: 10.1002/chem.201203906 ...
Learn about Naropin (Ropivacaine Hcl) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
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Thirteen amide-substituted phenyl arsenoxides (-RCONH2, -RSO2NH2) were, per unit arsenic, only 4.5 to 13.5 per cent as toxic as the parent phenyl arsenoxide. Since the treponemicidal activity in vitro was not reduced to the same degree, the ratio of treponemicidal activity: toxicity was 1.9 to 6.1 times more favorable than that of phenyl arsenoxide. The favorable effect of amide groups was confirmed for ten of these compounds by assays of toxicity and therapeutic activity in syphilitic rabbits.. When one or both of the amide hydrogens were substituted (e.g., -SO2N(CH3), -CONH-pyridine), the effect of the entire group shifted toward that of the terminal substituent. In most cases, substitution in the amide therefore caused an increased toxicity, and impaired the favorable effect of the amide group as such. Only in the case of the compounds with terminal hydroxyl acetamido or nitrile groups was the favorable effect of the amide altogether preserved, perhaps because these groups in themselves ...
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69278-64-4 - Amides, castor-oil, N-(3-(dimethylamino)propyl) - Searchable synonyms, formulas, resource links, and other chemical information.
N,N-Dibutyl-12-hydroxyoctadecan-1-amide/ACM16169485 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
MolCore offers CAS No.128340-47-6, Lys-Ala-Arg-Val-Nle-p-nitro-Phe-Glu-Ala-Nle amide for your research needs.Find product specific information including MFCD00133510,128340-47-6 MSDS,Price,Custom Synthesis.
The attached manual describes the XBridge Glycan BEH Amide, 2.5 µm XP, 130Å, and 3.5 µm Columns and Standards and includes user recommendations.
Sigma-Aldrich offers Sigma-A2163, N-Acetyl-Phe-Nle-Arg-Phe amide for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Sanomenen canviant la terminaci -oic de l cid per amida, si s n la funci principal. Si el seu carboni no es pot incloure dins la cadena principal, es canvia carbox lic per carboxamida i ja inclou el carboni. Si el nitrogen t substituents, sanomenen amb N com a localitzador, igual que a les amines. Exemples ...
Z-AKR-AMC | Z-Ala-Lys-Arg-AMC 877-03 5 mg | 215.00 EURBenzyloxycarbonyl-L-alanyl-L-lysyl-L-arginine-4-methyl-coumaryl-7-amide (M.W.
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Sca-1 and VEGFR-2 positive pro-angiogenic cells (PAC) predict outcome of patients with vascular disease. Activation of the renin-angiotensin-aldosterone system impairs PAC function. The effects of the direct renin inhibitor aliskiren on PAC numbers a
The present study is the first to show that HRP counteracts the beneficial cardiac effects of the renin inhibitor aliskiren. The most likely explanation for this finding is that HRP annihilated the blood pressure-lowering effect of aliskiren, thereby preventing the improvement of coronary endothelial function and cardiomyocyte hypertrophy that depend, at least in part, on the decrease in blood pressure.. In agreement with a previous study in stroke-prone SHRs,11 HRP, when infused alone, did not affect blood pressure or plasma RAS components. In that study, a 4-week infusion of HRP (0.1 mg/kg per 28 days or 3.57 μg/kg per day) decreased the cardiac Ang levels. The proposed underlying mechanism is a blockade of the prorenin-dependent Ang I formation occurring after prorenins activation when bound to the (P)RR. However, given the affinity of the (P)RR for prorenin (nanomolar range)5,19 and the actual prorenin levels in the heart (picomolar range),20,21 such prorenin-dependent cardiac Ang I ...
Synthesis and antimelanoma activity of sterically congested tertiary amide analogues of N-acetyl-4-S-cysteaminylphenol Interference with the biosynthetic pathway to melanin may be a useful means for developing new chemotherapeutic drugs to combat malignant melanoma. N-Acetyl-4-S-cysteaminylphenol (1) is an analogue of tyrosine that is involved in the pathway to melanin. It is probably oxidized selectively in melanocytes to an o-quinone that can alkylate thiol groups on important cellular enzymes, resulting in interference with cell growth and proliferation. We previously synthesized a range of more lipophilic analogues of I by independently varying the acyl portion and introducing substitution a to the nitrogen. Most of the new compounds displayed greater cytotoxicity than the original lead compound 1. We also made a series of tertiary amides that again showed higher cytotoxicity than 1. In this work three new acetamides and two new cyclohexanecarboxamides containing 4-S-cysteaminylphenol were ...
This study is the first to investigate the use of other antihypertensive therapies in combination with HCTZ in a population of obese patients with hypertension who have failed to achieve BP control with HCTZ monotherapy. The addition of aliskiren (150 mg) to treatment with HCTZ (25 mg) for 4 weeks provided a significant additional BP reduction (msSBP/DBP) of 4.4/2.5 mm Hg compared with continuing treatment with HCTZ alone, and increasing the dose of aliskiren to 300 mg for 4 weeks increased the treatment difference to 7.2/4.0 mm Hg. The additional BP reduction provided by combining aliskiren with HCTZ treatment almost doubled the rate of BP control in obese hypertensive patients at 12 weeks (58.4% versus 33.3% with HCTZ alone). The antihypertensive effects of aliskiren were similar to those observed with irbesartan and amlodipine.. Combination with aliskiren suppressed the increase in renin system activity (PRA) caused by HCTZ, whereas irbesartan and amlodipine increased PRA further. Our results ...
SAN FRANCISCO -- The use of the direct renin inhibitor aliskiren (Tekturna) failed to improve outcomes for patients with stable heart failure at 6 months or at 12 months, researchers found.
Among the GTP-binding proteins, Rho is known to function as a molecular switch in various cellular functions. Among the Rho effectors, the cellular function and signal transduction of Rho-kinase have been extensively studied. However, information about its in vivo functions is still limited. With the recent development of a specific Rho-kinase inhibitor such as Y-27632 and fasudil, the understanding of the role of the Rho/Rho-kinase pathway in vitro and in vivo has advanced. However, to date, there have been few studies investigating the role of Rho-kinase in renal disease. Recent studies have shown that Rho-kinase inhibitor significantly attenuated the tubulointerstitial fibrosis in kidney induced by unilateral ureteral obstruction. However, there have been few studies investigating the role of the Rho/Rho-kinase pathway in hypertensive glomerular sclerosis. In this review, we described the role of the Rho/Rho-kinase pathway in the progression of renal glomerulosclerosis in several forms of ...
821.1 - Compounds containing one, two, or three acyl groups attached to nitrogen bear the generic name "amide". When only one acyl group is attached to a nitrogen atom, the generic name "primary amide" may be used; when two acyl groups are so attached, the generic name "secondary amide" may be used; and when three acyl groups are so attached, the generic name "tertiary amide" may be used. Amides derived from carbon acids may be termed "carboxamides", those from sulfonic acids "sulfonamides", etc.; N-substituted primary and secondary amides may also be described as acylamines or, more specifically as monoacylamines and diacylamines, respectively. Note: As the nomenclature of amides of sulfur acids is described (though less extensively) in Rule C-641.8, the present Subsection is illustrated mostly for carbon acids.. See Recommendations93 R-5.7.8. ...
Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation transfer phenomenon that has potential for penumbra identification following stroke. The majority of the literature thus far has focused on generating pH-weighted contrast using magnetization transfer ratio asymmetry analysis instead of quantitative pH mapping. In this study, the widely used asymmetry analysis and a model-based analysis were both assessed on APT data collected from healthy subjects (n = 2) and hyperacute stroke patients (n = 6, median imaging time after onset = 2 hours 59 minutes). It was found that the model-based approach was able to quantify the APT effect with the lowest variation in grey and white matter (≤ 13.8 %) and the smallest average contrast between these two tissue types (3.48 %) in the healthy volunteers. The model-based approach also performed quantitatively better than the other measures in the hyperacute stroke patient APT data, where the quantified APT effect in the
A molecular mechanics (MM) force field-based empirical electrostatic potential map (MM map) for amide-I vibrations is developed with the aim of seeking a quick and reasonable approach to computing local mode parameters and their distributions in solution phase. Using N-methylacetamide (NMA) as a model compound, the instantaneous amide-I normal-mode parameters (transition frequency and dipole) obtained at the level of MM force fields are converted to solution phase values by a four-site potential scheme, but without the need for quantum mechanical frequency computations of solute-solvent clusters as are required in constructing ab initio-based electrostatic potential or field maps. The linear IR line shape of the amide-I mode in NMA obtained from the frequency-time correlation function on the basis of the MM map are found to be comparable to those from the ab initio-based maps. Our results show that the amide-I local mode parameters are largely determined by the solvated peptide structure rather ...
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity
INTRODUCTION: We recently developed and validated in existing trials a novel algorithm (PRE score) to predict long-term drug efficacy based on short-term (month-6) drug-induced changes in multiple risk markers. To show the value of the PRE score for ongoing and planned clinical trials, we here report the predicted long-term cardio-renal efficacy of aliskiren in type 2 diabetes, which was investigated in the ALTITUDE trial, but unknown at the time this study was conducted. METHODS: We established the relation between multiple risk markers and cardio-renal endpoints (as defined in ALTITUDE) using a background database from past clinical trials. The short-term effect of aliskiren on multiple risk markers was taken from the AVOID trial. A PRE score was developed by multivariate Cox analysis in the background population and was then applied to the baseline and month-6 measurements of the aliskiren treatment arm of the AVOID trial to predict cardio-renal risk. The net risk difference at these ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
4GJA: A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
4GJD: A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
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TABLE-US-00002 TABLE 2 Ex Characterizations 01 1H NMR spectrum (d6-DMSO, δ in ppm): 1.48 to 1.70 (m, 6H), 3.62 (broad unresolved m, 2H), 4.08 (broad unresolved m, 2H), 4.59 (d, J = 5.5 Hz, 2H), 5.27 (t, J = 5.5 Hz, 1H), 7.37 (broad d, J = 7.5 Hz, 1H), 7.48 (t, J = 7.5 Hz, 1H), 7.58 (broad d, J = 7.5 Hz, 1H), from 7.62 to 7.73 (m, 3H), 8.30 (s, 1H), 8.91 (t, J = 1.5 Hz, 1H). Mass spectrum (LC-MS-DAD-ELSD): m/z 336 [M + H].sup.+. 02 1H NMR spectrum (d6-DMSO, δ in ppm): 4.31 (m, 2H), 4.44 (m, 2H), 4.60 (d, J = 5.7 Hz, 2H), 5.27 (t, J = 5.7, Hz, 1H), 6.85 (m, 1H), 6.92 (dd, J = 8.1, 1.6 Hz, 1H), 7.05 (m, 1H), 7.38 (dt, J = 7.6, 1.4 Hz, 1H), 7.48 (t, J = 7.6 Hz, 1H), 7.59 (dt, J = 7.6, 1.4 Hz, 1H), 7.65-7.77 (m, 4H), 8.46 (s, 1H), 8.96 (t, J = 1.6 Hz, 1H). Mass spectrum (LC-MS-DAD-ELSD): m/z 386 [M + H].sup.+. 03 1H NMR spectrum (d6-DMSO, δ in ppm): 3.67 (broad unresolved m, 6H), 4.27 (broad unresolved m, 2H), 4.59 (d, J = 5.5 Hz, 2H), 5.28 (t, J = 5.5 Hz, 1H), 7.37 (broad d, J = 7.5 Hz, 1H), 7.48 ...
Used for treating high blood pressure. It may be used alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. Aliskiren is a direct renin inhibitor. It works by relaxing blood vessels. This lowers blood pressure and helps the heart to pump blood more easily.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
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The pharmacokinetics, biotransformation, and urinary excretion of ropivacaine (Naropin), a new local anesthetic agent, have been studied in six healthy male volunteers after a 15-min iv infusion of 152 mumol (50 mg) of [14C]ropivacaine, with a specific radioactivity of 22.5 kBq/mumol (8.8 kBq/mg). Blood, urine, and feces were collected for up to 96 hr after administration. The plasma and urine samples were analyzed for unchanged ropivacaine and for four of its metabolites, i.e. 3-OH-2,6-pipecoloxylidide (3-OH-PPX), 4-OH-ropivacaine, 3-OH-ropivacaine, and the N-dealkylated metabolite PPX, using GC and HPLC methods. The presence of 2,6-xylidine in plasma was also analyzed. The metabolites were quantified after acidic hydrolysis. The radioactivity could be followed in plasma for up to 14 hr after administration, with ropivacaine being the predominant compound in the early samples. The concentrations of the aforementioned metabolites in plasma were below or just above the lower limit of ...
Get Details of Amidation Manufacturers,Amidation Suppliers,Amidation Dealers, Amidation Exporters, Amidation Traders, Amidation Producers, Amidation Wholesalers, Amidation Companies
As the Baran lab peptide synthesis aficionado, Lara came on board to test the alkyl-alkyl cross-coupling reaction in one final chemoselectivity challenge: the direct modification of native peptides on the solid-phase. After all, if one has a reaction that is supposedly as easy as amide-bond formation, it better work on solid-phase. She prepared a handful of model peptides on Rink amide resin, each bearing a free side-chain (aspartic acid or glutamic acid) or a free α-carboxylic acid. The acids were activated on-resin as redox-active esters and then subjected directly to solid-phase nickel couplings with various diaklylzinc reagents. Before cleavage of the peptides from the solid support, all excess reagents were simply washed away, identical to the way excess peptide coupling reagents are washed away after amide bond formation on the solid-phase. In this way, we were able to repurpose age-old solid-phase synthesis techniques for late-stage, nickel-catalyzed C-C bond formation. Accessing the ...
TY - JOUR. T1 - Exploratory synthetic studies of the α-methoxylation of amides via cuprous ion-promoted decomposition of o-diazobenzamides. AU - Han, Gyoonhee. AU - LaPorte, Matthew G.. AU - McIntosh, Mathias C.. AU - Weinreb, Steven M.. AU - Parvez, Masood. PY - 1996/12/27. Y1 - 1996/12/27. N2 - A convenient nonelectrochemical amide oxidation method has been developed. The process involves a cuprous ion-promoted decomposition of o-diazobenzamides like 4, generated in situ from the corresponding o-aminobenzamides, to give N-acyliminium ion intermediate 9 via a 1,5-H-atom transfer, followed by metal-catalyzed oxidation of the resulting α-amidyl radical. The transformation produces α-methoxybenzamides 15 in good yields. An attempt was made to apply this oxidation method to a total synthesis of the alkaloid (-)-anisomycin (16). Scalemic o-aminobenzamide pyrrolidine derivatives 18a/18b underwent oxidation to give α-methoxylated amide substrates 19a/19b, respectively, in good yields. However, ...
2-pyrrolidinone and Salts Thereof. US2013/109854 A1, 5 May, 2013. 21. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. Imidazo(4,5-b)pyridine-6-carboxamides as anti-inflammatory agents. WO2012/076674 A1, 14 June, 2012. 20. Priepke, H.; Kuelzer, R.; Mack, J.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna E. 2-Aminobenz imidazole derivatives useful in the treatment of inflammation WO2012/076672 A1, 14 June, 2012. 19. Priepke, H.; Doods, H.; Kuelzer, R.; Pfau, R.; Stenkamp, D.; Pelcman, B.; Rönn, R.; Lubriks, D.; Suna, E. 2-(Arylamino)-3H-imidazo-[4,5-b]-pyridine-6-carboxamide derivatives and their use as MPGES-1 inhibitors. WO2012/022792 A1, 23 February, 2012. 18. Nilsson, P.; Pelcman, B.; Katkevics, M.; Suna, E.; Popovs, I. Bis aromatic compounds for use as LTC4 synthase inhibitors. WO 2010/103283 A1, 16 September, 2010. 17. Pfau, R.; Arndt, K.; Doods, H.; Klinder, K.; Kuelzer, R.; Lubriks, D.; Mack, J.; Pelcman, B.; ...
The Scottish Medicines Consortium issued on 5th December 2008 an advice on aliskiren (Rasilez, Tekturna in the US): Aliskiren (Rasilez) is not recommended for
This paper describes a protocol for imidazo[1,2-a]pyridine-2-carboxylic acids synthesis directly from condensation of substituted 2-aminopyridines and bromopyruvic acid. The recipe is applicable to a wide range of aminopyridines and can be telescoped with an amide formation to obtain Imidazo[1,2-a]pyridine-2-carboxamides in one continuous process.. ...
This study investigated the efficacy of locally administered ropivacaine for the prevention of post-operative pain in patients undergoing hepatic surgery.
TY - JOUR. T1 - Reactions of some halocetylenes with sodium amide. AU - Shavartsberg, M. S.. AU - Vasilevskii, S. F.. AU - Sinyakov, A. N.. PY - 1976/10/1. Y1 - 1976/10/1. N2 - 1. The action of sodium amide in ammonia on 4-chloroethynyl-N-alkylpyrazoles having a methyl group at position 5 leads to the formation of rearranged substitution products, i.e., the respective 5-(aminomethyl)-pyrazolylacetylenes. A suggestion is made about the mechanism of the reaction. 2. Under the same conditions 4-bromo- or 4-iodoethynyl-5-methylpyrazoles, like phenylchloroacetylene, exchange the halogen atom for sodium. At the same time a small amount of the aryl- or heteroarylacetonitrile is formed.. AB - 1. The action of sodium amide in ammonia on 4-chloroethynyl-N-alkylpyrazoles having a methyl group at position 5 leads to the formation of rearranged substitution products, i.e., the respective 5-(aminomethyl)-pyrazolylacetylenes. A suggestion is made about the mechanism of the reaction. 2. Under the same ...
ACQUITY BEH Amide columns retain extremely polar compounds, including carbohydrates and sugars. Based on BEH technology the ACQUITY Amide columns offer a chemically stable, trifunctionally bonded amide phase that is stable from pH 2 to 12 to enable the separation of polar analytes that span a wide range of polarity, structural moiety and pKa.
[65 Pages Report] Check for Discount on Ropivacaine mesylate Global Market and Forecast Research report by ChemReport. DescriptionWe provide independent and unbiased information on manufacturers, prices, production...
en] 5-HT1A receptors represent a major target for research and drug development due to their involvement in pathologies such as anxiety,1 depression,2 sleep and memory disorders,3,4 and schizophrenia.5 The main feature of many drugs having a 5-HT1A affinity is the presence of arylpiperazine moiety.6 Indeed, the protonated nitrogen and the aromatic ring of the arylpiperazine compounds are considered crucial for the interaction with the receptor.7 Interestingly, an in vitro binding study realized in our laboratory reveals the presence of the 1,2,3,6-tetrahydropyridine instead of the piperazine moiety in 4-arylpiperazine-ethyl carboxamide derivatives is highly favourable for 5-HT1A affinity. In order to better understand the favourable effect of this chemical modification, we have performed a conformational analysis of these compounds mainly based on the position of the phenyl ring relative to the piperazine and tetrahydropyridine ones. In the piperazine compounds, the phenyl ring is found in a ...
Carboxylic acids, acid halides, esters, and amides are easily reduced by strong reducing agents, such as lithium aluminum hydride (LiAlH 4). The carboxylic acid
Facile formation of allylzinc species from allylboronate and zinc amide was discovered. The boron-to-zinc exchange process occurred smoothly to afford the corresponding allylzinc amides, which were successfully employed in catalytic allylation reactions with electrophiles. Asymmetric catalysis using a chiral
Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymer supported equivalent of 1-hydroxybenzotriazole (HOBt) and is used to generate bound HOBt active esters. Treatment of bound HOBt esters with an amine leads to amide formation in generally high purity without the need for further purification and the supported reagent may also be used catalytically. ...
We are one of the leading manufacturers and suppliers of Maca Root Extract Powder 95% Maca amide, 4:1,10:1 in China, specialized in offering bulk customized products with low price. We warmly welcome you to wholesale or buy discount Maca Root Extract Powder 95% Maca amide, 4:1,10:1 in stock from our factory and check quotation with us.
Many different medications can cause problems when combined with aliskiren. This page of the eMedTV Web site covers ACE inhibitors, products that contain amiloride, and ARBs, and explains what you can do to help minimize the risk.
Trial assessed addition of aliskiren to help limit changes to the heart s shape and function in patients after heart attack (post-myocardial infarction)[1], , , , A small numerical reducti...
Adhesion strength has influence on ROCK activity and various cell activities in a dose dependent manner.A. To compare the relative levels of ROCK activation, de
MolPort offers (2E)-N-[4-({3-chloro-4-[(pyridin-2-yl)methoxy]phenyl}amino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide for your scientific research needs. It is also know by registry numbers ZINC000003916214, MFCD09752958. This compound is available from 10 suppliers, including AK Scientific, Inc., Axon Medchem.
The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
The invention relates to a process for producing a carboxamide of the formula ##STR1## which comprises reacting ##STR2## with an excess of urea in water, wherein the variables in the above formulae are as described herein.
Sigma-Aldrich offers abstracts and full-text articles by [Akbar Ali, G S Kiran Kumar Reddy, Hong Cao, Saima Ghafoor Anjum, Madhavi N L Nalam, Celia A Schiffer, Tariq M Rana].
92201-21-3 - Amides, C10-20 and C10-20-unsatd., N-(2-(2-(C9-19 and C9-19-unsatd. alkyl)-4,5-dihydro-1H-imidazol-1-yl)ethyl), hydrochlorides - Searchable synonyms, formulas, resource links, and other chemical information.
Hi All! I got 2-3 messages on ModelBuilder 3D and I do think it would be good to designate the package as deprecated as it fails in many cases. I would also like to share a bug : in many drug-size molecules the builder assigns bad MMFF94 atom types to the amide Ns, which results in bad 3D geometry, namely neglecting the amide plane. It works well in cases when the amide in like NC=OR, where R is alkyl group, but fails when the first R atom is not C. Therefore in cases like urea, hydroxyurea the result is bad. The problem was in MMFF94BasedAtomTypePattern where you have to change the N atom HOSECODE pattern N-[1-3];[CH]{1,3}.{1}+[A-Z]{0,3}+[,]?+=OC.*+ to N-[1-3];[CH]{1,3}.{1}+[A-Z]{0,3}+[,]?+=O[CNX].*+ to handle other types of amides. How can I report this bug ? Thanks, Daniel ...
Bachem offers H-4124 Propionyl-Amyloid β-Protein (31-34) amide for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
This pill with imprint 10 Amide 009 is White, Round and has been identified as Isoxsuprine hydrochloride 10 mg. It is supplied by Qualitest Pharmaceuticals Inc..
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
A lactam or cyclic amide is an amide in the molecule of which there are one or two carbon chains connecting the carbonyl carbon to the nitrogen atom.. eg:. ...
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus purus leo, consequat eu posuere eu, bibendum quis nulla. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Proin et dolor metus, iaculis molestie tellus. Nulla in purus leo, commodo vestibulum lorem ...
The compound formally obtained by the condensation reaction of two or more amino acid molecules, leading to an amide group, is called a peptide.. eg:. ...
Pill with imprint A185 is Purple, Capsule-shape and has been identified as Trimethobenzamide hydrochloride 300 mg. It is supplied by Amide Pharmaceutical Inc..
PetSmart in Round Rock, TX - Round Rock #0195 is conveniently located at 2601 S IH35 Pad E Round Rock, TX 78664. The stores phone number is (512) 218-1816.
Igneous rocks can be identified by the determination of the composition and texture of the rock. Once these two characteristics have been identified, the Igneous Rock Identification chart is used to identify the rock name.
Floating, freezing, and fizzing rocks! The Curious Crew goes digging into the makeup and science of igneous, sedimentary, and metamorphic rocks! STEM...
Anyone else looking forward to Stonedar and Rokkon? This time around, I think they should be full figures with snap-on rock plates.
Solomon SD, Appelbaum E, Manning WJ, et al; Aliskiren in Left Ventricular Hypertrophy (ALLAY) Trial Investigators. Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009; 119: 530-537 ...
The number of ambulatory surgical procedures is growing and local anesthesia represents the technique of choice for outpatients undergoing minor surgery. The aim of this study was to verify whether differences exist in postoperative pain relief using equipotent doses of two long-acting local anesthetics, ropivacaine and levobupivacaine, in patients who underwent minor breast surgery. A series of 86 consecutive women (median age=55, range=39-75 years) with small (,2 cm in size) breast masses requiring surgical excision were prospectively enrolled in the study. Patients were randomly selected to receive 75 mg/ml ropivacaine (group A, 42 patients) or 5 mg/ml levobupivacaine (group B, 44 patient). For post-surgical measurement of pain intensity a visual analog scale (VAS) was used. The age of the patients (56.4±9.6 vs. 56.7 ±9.5 years; p=0.88) and operative time (38.4 ± vs. 39.8 ±5.0 min; p=0.16), did not differ significantly between the groups (A vs. B). Transient adverse effects were observed ...
In fact, data from the only study of perineural infusion that varied both the infusion rate and concentration in a static ratio so that the total dose was comparable in each treatment group suggests that local anesthetic concentration and volume (rate) do not influence block effects as long as the total dose remains constant.13 These results, though, were based exclusively on continuous posterior lumbar plexus catheters, and therefore may not be applicable to femoral infusion because local anesthetic pharmacodynamics vary considerably among anatomic catheter sites. For example, increasing local anesthetic concentration has differing effects on the incidence of an insensate extremity depending upon catheter site location: increased for infraclavicular,14 decreased for popliteal,15 no difference for axillary,16 and variable for interscalene.8,17,18 Considering cFNB is often provided for analgesia following major surgical procedures of the knee in elderly patients, and a fall in this patient ...
No study has evaluated the efficacy of ropivacaine in peripheral nerve block of the lower extremity.The purpose of this prospective, randomized, double-blind study was to compare ropivacaine, bupivacaine, and mepivacaine during combined sciatic-femoral nerve block. Forty-five ASA physical status I o
Definition of cervical plexus block in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is cervical plexus block? Meaning of cervical plexus block as a finance term. What does cervical plexus block mean in finance?
Purpose: Vascular endothelial growth factor (VEGF) plays a central role in the development of retinal neovascularization and vascular leakage in diabetic retinopathy. Anti-VEGF therapy is widely used for these pathological conditions. However, frequent intravitreal injections are needed for maximum effect. In this study, we investigated the therapeutic potential of the topical ROCK (Rho-associated protein kinase) inhibitor K-115 in pathological retinal neovascularization and vascular leakage.. Methods: In vitro, human retinal microvascular endothelial cells (HRVECs) were pretreated with K-115 (3µM, 30µM), and then stimulated with human recombinant VEGF (25ng/ml). Migration and proliferation ability were assessed by cell migration and proliferation assay, respectively. The expression and localization of tight junction proteins (occludin/claudin) were evaluated by western blotting and immunohistochemistry, respectively. In vivo, normal saline vehicle, 0.4% or 0.8% K-115 eye drops were ...
BACKGROUND: The caudal block is the most commonly performed regional anesthesia technique in pediatric patients undergoing surgical procedures, but safety concerns raised by previous reports remain to be addressed. Our main objective in current investigation was to estimate the overall and specific incidence of complications associated with the performance of caudal block in children.. METHODS: This was an observational study using the Pediatric Regional Anesthesia Network database. A complication after a caudal block was defined by the presence of at least 1 of the following: block failure, vascular puncture, intravascular test dose, dural puncture, seizure, cardiac arrest, sacral pain, or neurologic symptoms. In addition, if a complication was also coded, the presence of temporary or permanent sequelae was evaluated. Additional exploratory analyses were performed to identify patterns of local anesthetic dosage.. RESULTS: Eighteen thousand six hundred-fifty children who received a caudal block ...
Local Anesthetics Toxicity and Management Gregory Pate, MD Department of Anesthesia Bremerton Naval Hospital Local Anesthetic Toxicity Topics Local Anesthetic Pharmacology Adverse Reactions to Local Anesthetics Types of Toxicity Acute Systemic Toxicity Management of Acute Systemic Toxicity Basics: Local Anesthetic Pharm Amino esters and Amino amides Metabolism Protein binding Lipophilichydrophilic balance Hydrogen Ion concentration Katzung, Basic & clinical pharm, 10th edition Basics: Local Anesthetic Mechanism Active form of the local anesthetic Modulated receptor theory Other possible mechanisms of action Millers Anesthesia, 6th edition Local Anesthetic Toxicity Topics Local Anesthetic Pharmacology Adverse Reactions to Local Anesthetics Types of Toxicity Acute Systemic Toxicity Management of Acute Systemic Toxicity Methemoglobinemia Prilocaine and Benzocaine Benzocaine sprays like Cetacaine EMLA cream which has prilocaine although this practice is still generally considered safe Seen with use ...

Plus itPlus it

This study was initiated to characterize PHI (peptide histidine isoleucine amide)-27-like peptides (PLPs) in rat and porcine ... The distribution and chromatographic characterization of PHI (peptide histidine isoleucine amide)-27-like peptides in rat and ... The distribution and chromatographic characterization of PHI (peptide histidine isoleucine amide)-27-like peptides in rat and ... The distribution and chromatographic characterization of PHI (peptide histidine isoleucine amide)-27-like peptides in rat and ...
more infohttp://www.jneurosci.org/content/4/11/2681

AmidesAmides

... are nitrogen-containing organic compounds with the general formula. Amides are formed when carboxylic acids ... The amide linkage is found in many useful synthetic polymers such as nylon. Amides are formed when amino acids react to form ...
more infohttp://hyperphysics.phy-astr.gsu.edu/hbase/Organic/amide.html

AmidesAmides

English version of Chinese product page To read more in English about Huntsmans product range please return to the home page, select language "English" then navigate to "Products" in the header menu.. ...
more infohttps://www.huntsman.com/corporate/a/Products/Chinese%20Product%20pages/Amides

O-aminosulfonylglycolic amides - BASF AktiengesellschaftO-aminosulfonylglycolic amides - BASF Aktiengesellschaft

... glycolic amides having a strong herbicidal action, herbicides containing these active ingredients, a process for controlling ... The new O-(aminosulfonyl)-glycolic amides may be prepared from a glycolic amide and an aminosulfonyl halide in accordance with ... substituted alkylsulfonylglycolic amides and imides substituted alkylaminosulfonylglycolic amides and imides substituted ... The glycolic amides used as starting materials may be prepared analogously to the process described in J. Chem. Soc., 1357, ...
more infohttp://www.freepatentsonline.com/4009192.html

fatty amide (CHEBI:29348)fatty amide (CHEBI:29348)

... is a lipid (CHEBI:18059) fatty amide (CHEBI:29348) is a monocarboxylic acid amide (CHEBI:29347) ... N-oleoyldopamine (CHEBI:31883) is a fatty amide (CHEBI:29348). N-oleoylglycine (CHEBI:73723) is a fatty amide (CHEBI:29348). N- ... fatty amide (CHEBI:29348) has functional parent fatty acid (CHEBI:35366) fatty amide (CHEBI:29348) is a fatty acid derivative ( ... Myxalamid D (CHEBI:31875) is a fatty amide (CHEBI:29348). Myxalamid S (CHEBI:31876) is a fatty amide (CHEBI:29348). N,N-bis(3- ...
more infohttp://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI%3A29348

Difluorocarboncyamidic amideDifluorocarboncyamidic amide

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=C32837631&Units=CAL

isonicotinic acid amideisonicotinic acid amide

... pyridine-4-carboxamide Pyridine-4-carboxylic acid amide pyridine-4-carboxylic acid amide 4- ... isonicotinic acid amide more infohttps://scitoys.com/scichem/jqp065/15074.html

Amide - WikipediaAmide - Wikipedia

An amide (/ˈæmaɪd/ or /ˈæmɪd/ or /ˈeɪmaɪd/),[1][2][3] also known as an acid amide, is a compound with the functional group RnE( ... Amide synthesisEdit. Many methods exist in amide synthesis.[9] On paper, the simplest method for making amides is by coupling a ... In primary and secondary amides, the presence of N-H dipoles allows amides to function as H-bond donors as well. Thus amides ... "amide - Definition of amide in English by Oxford Dictionaries". Oxford Dictionaries - English. Retrieved 15 April 2018.. ...
more infohttps://en.m.wikipedia.org/wiki/Amide

GRGDS, amideGRGDS, amide

... amide; This peptide inhibits the adhesion of human ovarian carcinoma OVCAR-3 cells to fibronectin, but not to laminin.; GRGDS- ...
more infohttps://anaspec.com/products/product.asp?id=32376

Flexible Rhinoscopy Medication: Local Anesthetics, Amides, Topical Vasoconstrictors, AntibioticsFlexible Rhinoscopy Medication: Local Anesthetics, Amides, Topical Vasoconstrictors, Antibiotics

Local Anesthetics, Amides. Class Summary. Local anesthetics block the initiation and conduction of nerve impulses. Anesthetics ...
more infohttps://emedicine.medscape.com/article/1890801-medication

Chemical Database: Alkali metal amides (EnvironmentalChemistry.com)Chemical Database: Alkali metal amides (EnvironmentalChemistry.com)

This page contains information on the chemical Alkali metal amides including: 1 synonyms/identifiers; U.S. Code of Federal ... Alkali metal amides. Identifications. *Synonyms/Related:*Alkali metal amides. 49 CFR 172.101 - Hazardous Materials Table. ... Alkali metal amides (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Alkali metal amides ... Alkali metal amides. 4.3. UN1390. II. 4.3. A6, A7, A8, A19, A20, IB7, IP2, T3, TP33. 151. 212. 241. Forbid. Forbid. E. 40, 52. ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/Alkali%A0metal%A0amides.html

Amides, C18-20-unsatd.,... - Substance Information - ECHAAmides, C18-20-unsatd.,... - Substance Information - ECHA

Amides, C18-20-unsatd., N,N-(3,3-dimethyl[1,1-biphenyl]-4,4-diyl)bis[α-(C14-16-unsatd. alkyl)-β-oxo- Regulatory process ... Amides, C18-20-unsatd., N,N-(3,3-dimethyl[1,1-biphenyl]-4,4-diyl)bis[α-(C14-16-unsatd. alkyl)-β-oxo- ...
more infohttps://echa.europa.eu/substance-information/-/substanceinfo/100.084.065

Angiotensin amide | Define Angiotensin amide at Dictionary.comAngiotensin amide | Define Angiotensin amide at Dictionary.com

Angiotensin amide definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ...
more infohttps://www.dictionary.com/browse/angiotensin-amide

Temporin A, amideTemporin A, amide

Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. This antimicrobial ... Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. This antimicrobial ...
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Thioctic acid amide | C8H15NOS2 - PubChemThioctic acid amide | C8H15NOS2 - PubChem

Thioctic acid amide , C8H15NOS2 , CID 863 - structure, chemical names, physical and chemical properties, classification, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/863

amides: Topics by WorldWideScience.orgamides: Topics by WorldWideScience.org

Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos/ Synthesis of new fatty acids amides from aminolysis ... Sample records for amides. from WorldWideScience.org. Sample records 1 - 9 shown. ... Toxicity of piperine amide analogs to larvae of Ascia monuste orseis Godart (Lepidoptera: Pieridae) and Spodoptera frugiperda ( ... Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their ...
more infohttps://worldwidescience.org/topicpages/multi/PT/a/amides.html

Rule C-821 Amides (Groups Containing One Nitrogen Atom)Rule C-821 Amides (Groups Containing One Nitrogen Atom)

... "secondary amide" may be used; and when three acyl groups are so attached, the generic name "tertiary amide" may be used. Amides ... Amides and Imides C-822, C-823, C-824, C-825, C-826, C-827. Nitriles, Isocyanides, and Their Derivatives C-831, C-832, C-833, C ... Amides and Imides. Rule C-821 821.1 - Compounds containing one, two, or three acyl groups attached to nitrogen bear the generic ... Note: As the nomenclature of amides of sulfur acids is described (though less extensively) in Rule C-641.8, the present ...
more infohttps://www.acdlabs.com/iupac/nomenclature/79/r79_540.htm

Lysergic amide | C16H17N3O - PubChemLysergic amide | C16H17N3O - PubChem

Lysergic amide , C16H17N3O , CID 10173 - structure, chemical names, physical and chemical properties, classification, patents, ...
more infohttps://pubchem.ncbi.nlm.nih.gov/compound/10173

Amide Technologies - Massachusetts Biotechnology CouncilAmide Technologies - Massachusetts Biotechnology Council

Amide Technologies. Life Sciences Contract Research & Manufacturing Cambridge, MA Amide Technologies has developed ...
more infohttps://www.massbio.org/member/amide-technologies-145207

Amide - Simple English Wikipedia, the free encyclopediaAmide - Simple English Wikipedia, the free encyclopedia

Amides in inorganic chemistry[change , change source]. An amide ion is different from an amide in organic chemistry. The amide ... Sodium amide is an example. Amides in organic chemistry[change , change source]. This section needs more information. ( ... Amides are also chemical compounds. They are made by reacting carboxylic acids like acetic acid with amines. There are many ... Amides made by deprotonating ammonia are very strong bases. ... Amide can refer to two different things. ...
more infohttps://simple.wikipedia.org/wiki/Amide

Debian -- Zoznam súborov balíka amide/wheezy/kfreebsd-i386Debian -- Zoznam súborov balíka amide/wheezy/kfreebsd-i386

MESSAGES/amide.mo /usr/share/man/man1/amide.1.gz /usr/share/menu/amide /usr/share/omf/amide/amide-C.omf /usr/share/omf/amide/ ... usr/share/doc/amide/todo.gz /usr/share/gnome/help/amide/C/amide.xml /usr/share/gnome/help/amide/C/figures/amide_main_window.png ... usr/share/gnome/help/amide/C/legal.xml /usr/share/gnome/help/amide/es/amide.xml /usr/share/gnome/help/amide/es/figures/amide_ ... usr/bin/amide /usr/share/applications/amide.desktop /usr/share/doc-base/amide /usr/share/doc/amide/README.Debian /usr/share/doc ...
more infohttps://packages.debian.org/sk/wheezy/kfreebsd-i386/amide/filelist

Fatty-acid amide hydrolase 1 (IPR030560) | InterPro | EMBL-EBIFatty-acid amide hydrolase 1 (IPR030560) | InterPro | EMBL-EBI

Fatty-acid amide hydrolase 1 (IPR030560). Short name: FAAH Family relationships *Amidase (IPR000120) *Fatty-acid amide ... Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of ... Structure and function of fatty acid amide hydrolase.. Annu. Rev. Biochem. 74 411-32 2005 ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR030560

Patent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google PatentsPatent US6380386 - Substituted aminosalicylic acid amides with fungicidal effect and ... - Google Patents

Acylaminosalicylic acid amides and their uses as pesticides. DE2210861A1. Mar 7, 1972. Sep 13, 1973. Hans Wirth Automaten. ... Substituted aminosalicylic acid amides with fungicidal effect and intermediate products for production thereof. US 6380386 B2 ... Halobenzyl substituted phenylaceto esters and amides and use thereof for prevention of harmful organisms. ... benz-amide, are already known (compare, for example, Biochim. Biophys. Acta (1993), 1142(3), 262-8, J. Med. Chem. (1990), 33(1 ...
more infohttp://www.google.com/patents/US6380386?dq=5,867,764

Patent US6710040 - Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors - Google PatentsPatent US6710040 - Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors - Google Patents

Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors. ... Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors ...
more infohttp://www.google.co.uk/patents/US6710040

DailyMed - Search Results for Amide Local AnestheticDailyMed - Search Results for Amide Local Anesthetic

SEARCH RESULTS for: Amide Local Anesthetic [Drug Class] (2214 results) * Share : JavaScript needed for Sharing tools. Bookmark ...
more infohttps://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Amide%20Local%20Anesthetic&searchdb=class
  • The particular class of poly(ester-amides) are those which include a polymeric fat. (google.com.au)
  • Co-owned and co-pending U.S. Patent Publication 2005-007461 describes polymeric compositions containing amide acetal groups, which are crosslinked by hydrolyzing the amide acetal groups, and subsequently reacting the hydroxyl groups and/or the amine functions that are formed to crosslink the composition. (freepatentsonline.com)
  • Amide Technologies has developed groundbreaking peptide synthesis by building instruments capable of delivering high-purity peptides quickly. (massbio.org)
  • They are also extensively used as precursors for the synthesis other bis(trimethylsilyl)amide complexes (see below). (wikipedia.org)
  • Temporin A is a highly hydrophobic antimicrobial peptide amide derived from the frog Rana temporaria. (anaspec.com)
  • This invention relates to a certain class of poly(ester-amide) polymers which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (google.com.au)
  • A certain class of poly(ester-amide) polymers are disclosed which are particularly suitable as hot melt adhesive compositions particularly advantageous for bonding plastics, such as polyester or polycarbonate polymers. (google.com.au)
  • Poly(ester-amide) adhesive compositions have been known for some time in the art, including the use as hot melt adhesives for various substrates such as metals, wood and plastics. (google.com.au)
  • Included in this background of poly(ester-amide) compositions are U.S. Pats. (google.com.au)
  • No. 3,650,999, related to poly(ester-amide) compositions, is generally useful as adhesives to a variety of substrates such as steel, aluminum, wood and plastic substrates. (google.com.au)
  • By the proper selection of reactants and using special polymerization techniques, a block copolymer poly(ester-amide) composition was prepared having certain advantages in high temperature properties over earlier adhesive compositions. (google.com.au)
  • Cross-linked amide acetal based coating compositions dry and cure rapidly without the potential problems created by VOC emissions. (freepatentsonline.com)
  • The remainder of this article is about the carbonyl - nitrogen sense of amide . (wikipedia.org)
  • Consequently, the nitrogen in amides is not pyramidal. (wikipedia.org)
  • One final thing to note when looking at the bonds of an amide is that there is also a hydrogen bond present between the active groups hydrogen and nitrogen atoms. (wikipedia.org)
  • Antimicrobial and allelopathic potential of the amides isolated from the roots of Ottonia martiana miq. (worldwidescience.org)
  • The amide linkage is found in many useful synthetic polymers such as nylon. (gsu.edu)