Amide synthases. Medical search

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.

A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.

An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. (1/66)

The gene thiI encodes a protein (ThiI) that plays a role in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine, but the reaction catalyzed by ThiI remains undetermined. Based upon sequence alignments, ThiI shares a unique "P-loop" motif with the PPi synthetase family, four enzymes that catalyze adenylation and subsequent substitution of carbonyl oxygens. To test whether or not this motif is critical for ThiI function, the Asp in the motif was converted to Ala (D189A), and a screen for in vivo 4-thiouridine production revealed the altered enzyme to be inactive. Further scrutiny of sequence data and the crystal structures of two members of the PPi synthetase family implicated Lys321 in the proposed adenylation function of ThiI, and the critical nature of Lys321 has been demonstrated by site-directed mutagenesis and genetic screening. Our results, then, indicate that ThiI catalyzes the adenylation of a substrate at the expense of ATP, a narrowing of possible reactions that provides a strong new basis for deducing the early steps in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine. (+info)

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (2/66)

The novobiocin biosynthetic gene cluster from Streptomyces spheroides NCIB 11891 was cloned by using homologous deoxynucleoside diphosphate (dNDP)-glucose 4,6-dehydratase gene fragments as probes. Double-stranded sequencing of 25.6 kb revealed the presence of 23 putative open reading frames (ORFs), including the gene for novobiocin resistance, gyrB(r), and at least 11 further ORFs to which a possible role in novobiocin biosynthesis could be assigned. An insertional inactivation experiment with a dNDP-glucose 4, 6-dehydratase fragment resulted in abolishment of novobiocin production, since biosynthesis of the deoxysugar moiety of novobiocin was blocked. Heterologous expression of a key enzyme of novobiocin biosynthesis, i.e., novobiocic acid synthetase, in Streptomyces lividans TK24 further confirmed the involvement of the analyzed genes in the biosynthesis of the antibiotic. (+info)

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. (3/66)

Novobiocic acid synthetase, a key enzyme in the biosynthesis of the antibiotic novobiocin, was cloned from the novobiocin producer Streptomyces spheroides NCIMB 11891. The enzyme is encoded by the gene novL, which codes for a protein of 527 amino acids with a calculated mass of 56,885 Da. The protein was overexpressed as a His(6) fusion protein in Escherichia coli and purified to apparent homogeneity by affinity chromatography and gel chromatography. The purified enzyme catalyzed the formation of an amide bond between 3-dimethylallyl-4-hydroxybenzoic acid (ring A of novobiocin) and 3-amino-4,7-dihydroxy-8-methyl coumarin (ring B of novobiocin) in an ATP-dependent reaction. NovL shows homology to the superfamily of adenylate-forming enzymes, and indeed the formation of an acyl adenylate from ring A and ATP was demonstrated by an ATP-PP(i) exchange assay. The purified enzyme exhibited both activation and transferase activity, i.e. it catalyzed both the activation of ring A as acyl adenylate and the subsequent transfer of the acyl group to the amino group of ring B. It is active as a monomer as determined by gel filtration chromatography. The reaction was specific for ATP as nucleotide triphosphate and dependent on the presence of Mg(2+) or Mn(2+). Apparent K(m) values for ring A and ring B were determined as 19 and 131 micrometer respectively. Of several analogues of ring A, only 3-geranyl-4-hydroxybenzoate and to a lesser extent 3-methyl-4-aminobenzoate were accepted as substrates. (+info)

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. (4/66)

Trypanothione [N1,N8-bis(glutathionyl)spermidine] is a unique metabolite found only in trypanosomatids, where it subsumes many of the functions of GSH in other organisms. In Crithidia fasciculata, two distinct ATP-dependent ligases, glutathionylspermidine synthetase (GspS; EC 6.3.1.8) and trypanothione synthetase (TryS; EC 6.3.1.9), are involved in the synthesis of trypanothione from GSH and spermidine. Both enzymes have been cloned previously, but expression in Escherichia coli produced insoluble and inactive protein. Here we report on the successful expression of soluble (His)6-tagged C. fasciculata GspS in E. coli. Following purification using nickel-chelating affinity chromatography, the tag sequence was removed and the enzyme purified to homogeneity by anion-exchange chromatography. The kinetic parameters of the recombinant enzyme have been determined using a coupled enzyme assay and also by HPLC analysis of end-product formation. Under optimal conditions (0.1 M K+-Hepes, pH 7.3) GspS has synthetase activity with apparent K(m) values for GSH, spermidine and MgATP of 242, 59 and 114 microM respectively, and a k(cat) of 15.5 s(-1). Glutathionylspermidine is formed as end product and the enzyme lacks TryS activity. Like E. coli GspS, the recombinant enzyme also possesses amidase activity (EC 3.5.1.78), hydrolysing glutathionylspermidine to GSH and spermidine with a k(cat) of 0.38 s(-1) and a K(m) of 500 microM. GspS can also hydrolyse trypanothione at about 1.5% of the rate with glutathionylspermidine. A single amino acid mutation (Cys-79-->Ala) is shown to ablate the amidase activity without affecting the synthetase activity. (+info)

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. (5/66)

Protozoa of the order Kinetoplastida differ from other organisms in their ability to conjugate glutathione (l-gamma-glutamyl-cysteinyl-glycine) and spermidine to form trypanothione [N(1),N(8)-bis(glutathionyl)spermidine], a metabolite involved in defense against chemical and oxidant stress and other biosynthetic functions. In Crithidia fasciculata, trypanothione is synthesized from GSH and spermidine via the intermediate glutathionylspermidine in two distinct ATP-dependent reactions catalyzed by glutathionylspermidine synthetase (GspS; EC ) and trypanothione synthetase (TryS; EC ), respectively. Here we have cloned a single copy gene (TcTryS) from Trypanosoma cruzi encoding a protein with 61% sequence identity with CfTryS but only 31% with CfGspS. Saccharomyces cerevisiae transformed with TcTryS were able to synthesize glutathionylspermidine and trypanothione, suggesting that this enzyme is able to catalyze both biosynthetic steps, unlike CfTryS. When cultures were supplemented with aminopropylcadaverine, yeast transformants contained glutathionylaminopropylcadaverine and homotrypanothione [N(1),N(9)-bis(glutathionyl)aminopropylcadaverine], metabolites that have been previously identified in T. cruzi, but not in C. fasciculata. Kinetic studies on recombinant TcTryS purified from Escherichia coli revealed that the enzyme displays high-substrate inhibition with glutathione (K(m) and K(i) of 0.57 and 1.2 mm, respectively, and k(cat) of 3.4 s(-1)), but obeys Michaelis-Menten kinetics with spermidine, aminopropylcadaverine, glutathionylspermidine, and MgATP as variable substrate. The recombinant enzyme possesses weak amidase activity and can hydrolyze trypanothione, homotrypanothione, or glutathionylspermidine to glutathione and the corresponding polyamine. (+info)

Stable ammonia-specific NAD synthetase from Bacillus stearothermophilus: purification, characterization, gene cloning, and applications. (6/66)

Bacillus stearothermophilus H-804 isolated from a hot spring in Beppu, Japan, produced an ammonia-specific NAD synthetase (EC 6.3.1.5). The enzyme specifically used NH3 as an amide donor for the synthesis of NAD as it formed AMP and pyrophosphate from deamide-NAD and ATP. None of the l-amino acids tested, such as l-asparagine or l-glutamine, or other amino compounds such as urea, uric acid, or creatinine was used instead of NH3. Mg2+ was needed for the activity, and the maximum enzyme activity was obtained with 3 mM MgCl2. The molecular mass of the native enzyme was 50 kDa by gel filtration, and SDS-PAGE showed a single protein band at the molecular mass of 25 kDa. The optimum pH and temperature for the activity were from 9.0 to 10.0 and 60 degrees C, respectively. The enzyme was stable at a pH range of 7.5 to 9.0 and up to 60 degrees C. The Km for NH3, ATP, and deamide-NAD were 0.91, 0.052, and 0.028 mM, respectively. The gene encoding the enzyme consisted of an open reading frame of 738 bp and encoded a protein of 246 amino acid residues. The deduced amino acid sequence of the gene had about 32% homology to those of Escherichia coli and Bacillus subtilis NAD synthetases. We caused the NAD synthetase gene to be expressed in E. coli at a high level; the enzyme activity (per liter of medium) produced by the recombinant E. coli was 180-fold that of B. stearothermophilus H-804. The specific assay of ammonia and ATP (up to 25 microM) with this stable NAD synthetase was possible. (+info)

Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. (7/66)

NAD synthetase catalyzes the final step in the biosynthesis of NAD. In the present study, we obtained cDNAs for two types of human NAD synthetase (referred as NADsyn1 and NADsyn2). Structural analysis revealed in both NADsyn1 and NADsyn2 a domain required for NAD synthesis from ammonia and in only NADsyn1 an additional carbon-nitrogen hydrolase domain shared with enzymes of the nitrilase family that cleave nitriles as well as amides to produce the corresponding acids and ammonia. Consistent with the domain structures, biochemical assays indicated (i) that both NADsyn1 and NADsyn2 have NAD synthetase activity, (ii) that NADsyn1 uses glutamine as well as ammonia as an amide donor, whereas NADsyn2 catalyzes only ammonia-dependent NAD synthesis, and (iii) that mutant NADsyn1 in which Cys-175 corresponding to the catalytic cysteine residue in nitrilases was replaced with Ser does not use glutamine. Kinetic studies suggested that glutamine and ammonia serve as physiological amide donors for NADsyn1 and NADsyn2, respectively. Both synthetases exerted catalytic activity in a multimeric form. In the mouse, NADsyn1 was seen to be abundantly expressed in the small intestine, liver, kidney, and testis but very weakly in the skeletal muscle and heart. In contrast, expression of NADsyn2 was observed in all tissues tested. Therefore, we conclude that humans have two types of NAD synthetase exhibiting different amide donor specificity and tissue distributions. The ammonia-dependent synthetase has not been found in eucaryotes until this study. Our results also indicate that the carbon-nitrogen hydrolase domain is the functional domain of NAD synthetase to make use of glutamine as an amide donor in NAD synthesis. Thus, glutamine-dependent NAD synthetase may be classified as a possible glutamine amidase in the nitrilase family. Our molecular identification of NAD synthetases may prove useful to learn more of mechanisms regulating cellular NAD metabolism. (+info)

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. (8/66)

NAD+ is an essential co-enzyme for redox reactions and is consumed in lysine deacetylation and poly(ADP-ribosyl)ation. NAD+ synthetase catalyzes the final step in NAD+ synthesis in the well characterized de novo, salvage, and import pathways. It has been long known that eukaryotic NAD+ synthetases use glutamine to amidate nicotinic acid adenine dinucleotide while many purified prokaryotic NAD+ synthetases are ammonia-dependent. Earlier, we discovered that glutamine-dependent NAD+ synthetases contain N-terminal domains that are members of the nitrilase superfamily and hypothesized that these domains function as glutamine amidotransferases for the associated synthetases. Here we show yeast glutamine-dependent NAD+ synthetase Qns1 requires both the nitrilase-related active-site residues and the NAD+ synthetase active-site residues for function in vivo. Despite failure to complement the lethal phenotype of qns1 disruption, the former mutants retain ammonia-dependent NAD+ synthetase activity in vitro, whereas the latter mutants retain basal glutaminase activity. Moreover, the two classes of mutants fail to trans-complement despite forming a stable heteromultimer in vivo. These data indicate that the nitrilase-related domain in Qns1 is the fourth independently evolved glutamine amidotransferase domain to have been identified in nature and that glutamine-dependence is an obligate phenomenon involving intramolecular transfer of ammonia over a predicted distance of 46 A from one active site to another within Qns1 monomers. (+info)

VibH Is an Amide Synthase Homologous to Nonribosomal Peptide Synthetase Condensation Domains". Biochemistry. 39 (50): 15514. ...

https://en.wikipedia.org/wiki/Vibriobactin

... amide synthases). The systematic name of this enzyme class is 4-methylene-L-glutamate:ammonia ligase (AMP-forming). This enzyme ... Winter HC, Su TZ, Dekker EE (1983). "4-methyleneglutamine synthetase: a new amide synthetase present in germinating peanuts" ( ...

https://en.wikipedia.org/wiki/4-methyleneglutamate—ammonia_ligase

... amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in common ...

https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase

... amide synthases). The systematic name of this enzyme class is glutathionylspermidine:glutathione ligase (ADP-forming). The ... Targeting trypanothione synthase could be a novel way of preventing and curing these diseases through disruption of the ... Evidence for this regulation is that the residues which allow the synthase domain to block the amidase active site are highly ... The main function of trypanothione synthase is to use the free energy generated from ATP hydrolysis to conjugate glutathione ...

https://en.wikipedia.org/wiki/Trypanothione_synthase

... amide synthases). The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP- ... In enzymology, a glutathionylspermidine synthase (EC 6.3.1.8) is an enzyme that catalyzes the chemical reaction glutathione + ...

https://en.wikipedia.org/wiki/Glutathionylspermidine_synthase

... amide synthases). The systematic name of this enzyme class is D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L- ...

https://en.wikipedia.org/wiki/D-aspartate_ligase

... amide synthases). The systematic name of this enzyme class is L-glutamate:putrescine ligase (ADP-forming). Other names in ...

https://en.wikipedia.org/wiki/Glutamate—putrescine_ligase

... amide synthases). The systematic name of this enzyme class is deamido-NAD+:ammonia ligase (AMP-forming). Other names in common ... In enzymology, a NAD+ synthase (EC 6.3.1.5) is an enzyme that catalyzes the chemical reaction ATP + deamido-NAD+ + NH3 ⇌ {\ ... use include NAD+ synthetase, NAD+ synthase, nicotinamide adenine dinucleotide synthetase, and diphosphopyridine nucleotide ...

https://en.wikipedia.org/wiki/NAD _synthase

... amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in common ...

https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase_(ADP-forming)

... amide synthases). The systematic name of this enzyme class is L-glutamate:ethylamine ligase (ADP-forming). Other names in ...

https://en.wikipedia.org/wiki/Glutamate—ethylamine_ligase

In all, rifA-E assemble a linear undecaketide and are followed by rifF, which encodes an amide synthase and causes the ... "RifH" encodes aminoDAHP synthase that catalyzes the condensation between 1-deoxy-1-imino-d-erythrose 4-phosphate and ... RifA through rifE encode a type I polyketide synthase module, with the loading module being a non-ribosomal peptide synthetase ... Other types of genes seem to perform post-synthase modifications of the original polyketide. Lepetit introduced Rifampicin, an ...

https://en.wikipedia.org/wiki/Rifamycin

Glutamate synthase (Fd-GOGAT and NADH-GOGAT) transfer the amide group onto a 2-oxoglutarate molecule producing two glutamates. ... Lea, P. J.; Miflin, B. J. (2003). "Glutamate synthase and the synthesis of glutamate in plants". Plant Physiology and ... In the chloroplasts, glutamine synthetase incorporates this ammonia as the amide group of glutamine using glutamate as a ... Ammonia (both absorbed and synthesized) is incorporated into amino acids via the glutamine synthetase-glutamate synthase (GS- ...

https://en.wikipedia.org/wiki/Nitrogen_assimilation

... peptide-alpha-amide synthetase, synthase, peptide alpha-amide, peptide alpha-amidating enzyme, peptide alpha-amide synthase, ... Bradbury AF, Finnie MD, Smyth DG (1982). "Mechanism of C-terminal amide formation by pituitary enzymes". Nature. 298 (5875): ...

https://en.wikipedia.org/wiki/Peptidylglycine_monooxygenase

... adenylosuccinate synthase MeSH D08.811.464.259.200 - amide synthases MeSH D08.811.464.259.200.200 - aspartate-ammonia ligase ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ... carbamoyl-phosphate synthase (ammonia) MeSH D08.811.464.259.400 - carbon-nitrogen ligases with glutamine as amide-n-donor MeSH ... nitric oxide synthase type i MeSH D08.811.682.664.500.772.500 - nitric oxide synthase type ii MeSH D08.811.682.664.500.772.750 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)

The amidotransferase domain is responsible for removal of the amide nitrogen from the glutamine substrate. The class I ... GMP synthase forms a tetramer in an open box shape, which is a dimer of dimers. The R interfaces are held together with a ... GMP synthase is the second step in the generation of GMP from IMP; the first step occurs when IMP dehydrogenase generates XMP, ... GMP synthase is also involved in amino acid metabolism because it generates L-glutamate from L-glutamine. This enzyme is widely ...

https://en.wikipedia.org/wiki/GMP_synthase

It is composed of a nitrothiazole-ring and a salicylic acid moiety which are linked together by an amide bond ... NTZ is ... In enzymology, a pyruvate synthase (EC 1.2.7.1) is an enzyme that catalyzes the interconversion of pyruvate and acetyl-CoA. It ... Gehring U, Arnon DI (1972). "Purification and properties of -ketoglutarate synthase from a photosynthetic bacterium". J. Biol. ...

https://en.wikipedia.org/wiki/Pyruvate_synthase

... which is where the catalysis of amide bond formation takes place. This structure is positioned similarly to the aminoacyl ... Cyclodipeptide synthases (CDPSs) are a newly defined family of peptide-bond forming enzymes that are responsible for the ... "Cyclodipeptide synthases, a family of class-I aminoacyl-tRNA synthetase-like enzymes involved in non-ribosomal peptide ... "Cyclodipeptide synthases are a family of tRNA-dependent peptide bond-forming enzymes". Nature Chemical Biology. 5 (6): 414-420 ...

https://en.wikipedia.org/wiki/Cyclodipeptide_synthases

It is then converted with 8-methyl-6-nonenoic acid into capsaicin by the enzyme capsaicin synthase. Acylation of vanillylamine ... using Schotten-Baumann reactions can provide amide derivatives. Examples include nonivamide (a component of some pepper sprays ...

https://en.wikipedia.org/wiki/Vanillylamine

The hydroperoxy ligand deprotonates the amide which then closes the β-lactam ring by a nucleophilic attack at the thioaldehyde ... L-cysteinyl-D-valine synthase (ACV synthase). This allows for the binding of the substrate ACV to the deprotonated thiol group ... Isopenicillin N synthase (IPNS) is a non-heme iron protein belongig to the 2-oxoglutarate (2OG)-dependent dioxygenases ... The active sites of most isopenicillin N synthases contain an iron ion. This enzyme is also called isopenicillin N synthetase. ...

https://en.wikipedia.org/wiki/Isopenicillin_N_synthase

Nid is coordinated to two cysteine molecules and two backbone amide compounds, and is in a square-planar coordination. The ... Acetyl-CoA synthase (ACS), not to be confused with Acetyl-CoA synthetase or Acetate-CoA ligase (ADP forming), is a nickel- ... Acetyl-CoA Synthase (ACS) and carbon monoxide dehydrogenase (CODH) are integral enzymes in this one pathway and can perform ... The recommended name for this enzyme is CO-methylating acetyl-CoA synthase. In nature, there are six different pathways where ...

https://en.wikipedia.org/wiki/CO-methylating_acetyl-CoA_synthase

Intramolecular amide N-alkylation of alpha-haloacetamide amides 8 with ethanolic potassium hydroxide using ultrasonication gave ... In general, they arise by the action of a tRNA-dependent cyclodipeptide synthases, a type of enzyme responsible for creating a ... Commonly, an isonitrile is chosen to give a labile terminal amide to enable cyclization. For example, the direct 2,5-DKP ring ... 2,5-Diketopiperazines are typically prepared by one of three methods: amide bond formation, N-alkylation and C-acylation. Most ...

https://en.wikipedia.org/wiki/2,5-Diketopiperazine

... synthase, glutamate synthase (NADPH), glutamate synthetase (NADP), glutamine amide-2-oxoglutarate aminotransferase ( ... Glutamate synthase (NADH) Glutamate synthase (ferredoxin) Temple SJ, Vance CP, Gantt JS (1998). "Glutamate synthase and ... NADPH-dependent glutamate synthase, NADPH-glutamate synthase, and NADPH-linked glutamate synthase. As of late 2007, only one ... In enzymology, a glutamate synthase (NADPH) (EC 1.4.1.13) is an enzyme that catalyzes the chemical reaction L-glutamine + 2- ...

https://en.wikipedia.org/wiki/Glutamate_synthase_(NADPH)

It has no degrading action on amide, plasminogen and casein. In addition, hementerin inhibits platelet aggregation induced by ... Inhibition is probably achieved by enhanced nitric oxide synthase activity. Calcium is a cofactor (ligand) in this activity. ...

https://en.wikipedia.org/wiki/Hementerin

"Structure of an amide bond forming F(420):gamma-glutamyl ligase from Archaeoglobus fulgidus -- a member of a new family of non- ... ribosomal peptide synthases". Journal of Molecular Biology. 372 (2): 456-69. doi:10.1016/j.jmb.2007.06.063. PMC 2678844. PMID ...

https://en.wikipedia.org/wiki/Coenzyme_F420-0:L-glutamate_ligase

https://en.wikipedia.org/wiki/Coenzyme_F420-1:gamma-L-glutamate_ligase

... is an orally active thromboxane synthase inhibitor. It has shown a significant clinical improvement in patients with ... Hydrolysis of the amide function completes the synthesis of dazoxiben. Belch, J. J.; Cormie, J.; Newman, P.; McLaren, M.; ...

https://en.wikipedia.org/wiki/Dazoxiben

Nickel amide, Ni(NH2)2 is a deep red compound that contains Ni6 clusters surrounded by 12 NH2 groups. Nickel amide also forms a ... CO-methylating acetyl-CoA synthase contains two active nickel atoms, one is held in a square planar coordination by two ... Other homoleptic nickel amides derived by substituting the hydrogen atoms are Ni[N(C6H5)2]2 (diphenyl) and boryl amides Ni[ ... cysteine and two amide groups, and the other nickel is held by three sulfur atoms. It is used to catalyse the reduction of ...

https://en.wikipedia.org/wiki/Nickel_compounds

The gene ann1 encode for an ATP-dependent amide synthetase and is predicted to condense the amine of the C5N group with the ... The ann2 gene encode for a 5-aminolevulinate synthase which condenses glycine and succinyl-CoA in a Claisen-like reaction to ... Genes ann4 and ann5 are the polyketide synthase part of the biosynthesis. Gene ann4 is organized in four modules, including the ... Annimycin (4-(Z)-annimycin) is a polyenoic acid amide natural product produced by Streptomyces calvus. Annimycin inhibits the ...

https://en.wikipedia.org/wiki/Annimycin

This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase. Hersh LB (1970). "5-hydroxy-N-methylpyroglutamate ... specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. ...

https://en.wikipedia.org/wiki/N-methyl-2-oxoglutaramate_hydrolase

... lanosterol synthase and squalene-hopene cyclase microsomal prostaglandin E synthase carnitine O-palmitoyltransferase 2 There ... are also structures of integral monotopic domains of transmembrane proteins: monoamine oxidases A and B fatty acid amide ... "A Computational Protocol for the Integration of the Monotopic Protein Prostaglandin H2 Synthase into a Phospholipid Bilayer". ...

https://en.wikipedia.org/wiki/Integral_monotopic_protein

The enzyme phosphoribosylamine-glycine ligase catalyses the reaction forming an amide bond: PRA + glycine + ATP → GAR + ADP + ... Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase". Angewandte Chemie International Edition. 49 ...

https://en.wikipedia.org/wiki/Phosphoribosylamine

Attachment of sugars to the nitrogen atom in an amide group - such as the amide group of an asparagine - requires an enzyme, as ... The Haemophilus influenzae N-glycosyltransferase has domains with homologies to glutathione S-transferase and glycogen synthase ... Among these are a deprotonation of the amide, an interaction between a hydroxyl group in the substrate sequon with the amide (a ... and two interactions involving acidic amino acids in the enzyme with each hydrogen atom of the amide group. This mechanism is ...

https://en.wikipedia.org/wiki/N-glycosyltransferase

... amide - amine - amino - amino acid - amino acid receptor - amino acid sequence - amino acid sequence homology - aminobutyric ... ATP synthase - ATPase - atrial natriuretic factor - atrial natriuretic factor receptor - Avogadro constant - axon B cell - ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

It is found at very low levels (nM) in most tissues and is inactivated by the fatty acid amide hydrolase. Subsequently, another ... 1995). "Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals". Cell ... The first such lipid to be isolated was anandamide which is the arachidonoyl amide of ethanolamine. Anandamide is formed via ... GluCer is formed by the glycosylation of ceramide in an organelle called Golgi via enzymes called glucosylceramide synthase ( ...

https://en.wikipedia.org/wiki/Lipid_signaling

A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase. The specific reaction ... "Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid ... Nina M, Bernèche S, Roux B (2000). "Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to ... Liu J, Seibold SA, Rieke CJ, Song I, Cukier RI, Smith WL (June 2007). "Prostaglandin endoperoxide H synthases: peroxidase ...

https://en.wikipedia.org/wiki/Cyclooxygenase

Seco, EM; Cuesta, T; Fotso, S; Laatsch, H; Malpartida, F (May 2005). "Two polyene amides produced by genetically modified ... "Identification and characterization of a novel citrate synthase from No. 7 strain M1033". Biotechnology and Applied ...

https://en.wikipedia.org/wiki/Streptomyces_diastaticus

Enzyme SAICAR synthetase, along with amino group from aspartate forms an amide bond to create N-succinyl-5-aminoimidazale-4- ... closure of the second ring structure is carried out by IMP synthase to form IMP, where IMP fate would lead to the formation of ...

https://en.wikipedia.org/wiki/Ribonucleotide

FABP inhibitors attenuate the breakdown of anandamide by the enzyme fatty acid amide hydrolase (FAAH) in cell culture. One of ... Activation of CB1 enhances AMT activity through increased nitric oxide synthase (NOS) activity and subsequent increase of NO ... A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding ... "Anandamide Externally Added to Lipid Vesicles Containing-Trapped Fatty Acid Amide Hydrolase (FAAH) Is Readily Hydrolyzed in a ...

https://en.wikipedia.org/wiki/Endocannabinoid_transporter

The name is derived from the Sanskrit word for bliss and -amide. It has a pharmacology similar to THC, although its structure ... Next, CBGA is independently converted to either CBG, THCA, CBDA or CBCA by four separate synthase, FAD-dependent dehydrogenase ...

https://en.wikipedia.org/wiki/Cannabinoid

The unusual gamma amide linkage in glutathione protects it from hydrolysis by peptidases. Glutathione is the most abundant ... Ha SB, Smith AP, Howden R, Dietrich WM, Bugg S, O'Connell MJ, Goldsbrough PB, Cobbett CS (June 1999). "Phytochelatin synthase ... Ha SB, Smith AP, Howden R, Dietrich WM, Bugg S, O'Connell MJ, Goldsbrough PB, Cobbett CS (June 1999). "Phytochelatin synthase ... This conversion requires the enzyme glutamate-cysteine ligase (GCL, glutamate cysteine synthase). This reaction is the rate- ...

https://en.wikipedia.org/wiki/Glutathione

Mapracorat is one of a number of trifluoropropanolamines and -amides which are less obviously steroid-like in structure. Other ... These target genes encode proteins such as cyclooxygenase, NO synthase, phospholipase A2, tumor necrosis factor, transforming ...

https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator

A set of NRPS enzymes (peptide synthase VpsA, VpsB, and VpsC) are responsible for assembling the heptapeptide. (Figure 2). VpsA ... synthesis occurs through distinct modules that can load and extend the protein by one amino acid per module through the amide ...

https://en.wikipedia.org/wiki/Vancomycin

Synthesis of phenyl-[1-aminoalkyl-benzimidazolyl-(2)]-acetic acid esters and amides]. Helvetica Chimica Acta (in German). 43 (6 ... Novel Dual Action Neuronal Nitric Oxide Synthase Inhibitors with μ-Opioid Agonist Activity". ACS Medicinal Chemistry Letters. 3 ...

https://en.wikipedia.org/wiki/List_of_benzimidazole_opioids

Utani and his coworkers substituted 19 amino acids at Trp49 of the tryptophan synthase and he measured the free energy of ... this scale used normal phase liquid chromatography and showed the retention of 121 peptides on an amide-80 column. The absolute ... of the amino acid residue in a series of variant proteins substituted at a unique position of tryptophan synthase alpha subunit ...

https://en.wikipedia.org/wiki/Hydrophobicity_scales

These metabolites have been named EXA4 ethanol amide, EXC4 ethanol amide, EXD4 ethanol amide, and EXE4 ethanol amide. These ... EXC4 via LTC4 synthase aka "glutathione S-transferase II" EXC4 → EXD4 via unidentified gamma-glutamyltransferase class enzyme ... EXD4 ethanol amide, and EXE4 ethanol amide. The activity and function of these ethanol amide metabolites has not been reported ... by conjugation to glutathione through the action of leukotriene C4 synthase. EXC4 contains glutathione (i.e. γ-L-glutamyl-L- ...

https://en.wikipedia.org/wiki/Eoxin

McGeoch, J.E.M.; McGeoch, M.W. (11 September 2007). "Entrapment of water by subunit c of ATP synthase". Journal of the Royal ... W.; Samoril, Tomas; Zapotok, David; McGeoch, Julie E. M. (28 July 2017). "Polymer amide as a carrier of 15N in Allende and ... McGeoch, J.E.M.; McGeoch, M.W. (21 July 2014). "Polymer Amide as an Early Topology". PLOS One. 9 (7): e103036. Bibcode: ... McGeoch, J.E.M.; McGeoch, M.W. (2015). "Polymer amide in the Allende and Murchison meteorites". Meteoritics & Planetary Science ...

https://en.wikipedia.org/wiki/Hemolithin

Chemically, it is an amide formed between serotonin and ferulic acid. It has in vitro anti-atherogenic activity. Serotonin ... In plants, the enzyme anthranilate synthase (AS) is composed of two subunits that modulate the production or suppression of ...

https://en.wikipedia.org/wiki/N-Feruloylserotonin

Thiazole synthase EC 2.8.1.11: Molybdopterin synthase sulfurtransferase EC 2.8.1.12: Molybdopterin synthase EC 2.8.1.13: tRNA- ... In linear amides) Urease (EC 3.5.1.5) Category:EC 3.5.2 (In cyclic amides) Beta-lactamase (EC 3.5.2.6) Category:EC 3.5.3 (In ... Trans-feruloyl-CoA synthase EC 6.2.1.35: ACP-SH:acetate ligase EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase EC 6.2.1.37: 3- ... Biotin synthase EC 2.8.1.7: Cysteine desulfurase EC 2.8.1.8: Lipoyl synthase EC 2.8.1.9: Molybdenum cofactor sulfurtransferase ...

https://en.wikipedia.org/wiki/List_of_enzymes

The amide group transfer from glutamine is fueled by ATP hydrolysis. In humans, pyrimidine rings (C, T, U) can be degraded ... First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for ... by an amide nitrogen donated from either glutamine (N), glycine (N&C), aspartate (N), folic acid (C1), or CO2. This is the ...

https://en.wikipedia.org/wiki/Nucleotide

... , in addition, evokes endothelial nitric oxide synthase activation and stimulates, through a 5-HT1B receptor-mediated ... Zeiss DR, Piater LA, Dubery IA (2021). "Hydroxycinnamate Amides: Intriguing Conjugates of Plant Protective Metabolites". Trends ...

https://en.wikipedia.org/wiki/Serotonin

Selection of RNA amide synthases.. *T. Wiegand, R. Janssen, B. Eaton. *. Biology, Chemistry ...

https://www.semanticscholar.org/paper/Ribozyme-Catalysis-of-Metabolism-in-the-RNA-World-Chen-Li/ee7d58a32a921574eb9967fa2c8eb3cdbde97f39

... amide synthases). 6.3.1.15 8-demethylnovobiocic acid synthase. K12709 novL, cloL, couL; 8-demethylnovobiocic acid synthase. ... 8-demethylnovobiocic acid synthase;. novL (gene name);. novobiocin ligase;. novobiocic acid synthetase (misleading);. 8- ... An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. ... K12709 novL, cloL, couL; 8-demethylnovobiocic acid synthase. Enzymes [BR:ko01000]. 6. Ligases. 6.3 Forming carbon-nitrogen ...

https://www.genome.jp/entry/K12709+6.3.1.15+R10453

Amide Synthases Entry term(s). Acid Amide Ligases Acid Ammonia Ligases Acid-Amide Ligases Acid-Ammonia Ligases Ligases, Acid- ... Amide synthases Entry term(s):. Acid Amide Ligases. Acid Ammonia Ligases. Acid-Amide Ligases. Acid-Ammonia Ligases. Ligases, ... Amide Synthases - Preferred Concept UI. M0029294. Scope note. Enzymes that catalyze the joining of either ammonia or an amide ... Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a ...

https://decs.bvsalud.org/en/ths/resource/?id=33442

Deficiency of amide synthase Active Synonym false false 205052017 Deficiency of acid-ammonia ligase Active Synonym false false ...

https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=124721006

... amide; NM, nanomaterial; NOS, nitric oxide synthase; NEUT, neutrophilic granulocyte count; NP, nanoparticle; nSPs, nanosilica ...

https://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-fulltext-article-IJN

Acid Amide Ligases .. Acid Ammonia Ligases .. Ligases, Acid-Amide .. Ligases, Acid-Ammonia .. Synthases, Amide .. 0.50. ... Amide Synthases .. Acid-Amide Ligases .. Acid-Ammonia Ligases .. ... D08.811.464.259.200 Amide Synthases .. HP4 Materia Medica .. ...

http://trigramas.bireme.br/cgi-bin/mx/[email protected]?collection=DeCSi&lang=p&minsim=0.30&maxrel=10&text=Aqua%20Ammoniae

... nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS, EC ... of N-nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS ... cinnamic amides together were performed in this study. Twenty-four N-nitro acid amide derivatives compounds were synthesized, ... Although the N-nitro amides group and the adjacent aromatic ring are located in the entrance of channel leading to the active ...

https://www.hindawi.com/journals/jchem/2016/8583765/

alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on ...

https://www.cathdb.info/pdb/1csr

Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases. Biochemistry ... The structure of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound also ... The structure of Rat Nnos D597N/M336V Double Mutant with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound, PDB code: ... Amino-L-Proline Amide Bound, PDB code: 1zzr:. Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; ...

http://fluorine.atomistry.com/pdb1zzr.html

Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. Nat.Struct.Mol.Biol. V. 11 ... The structure of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound also ... The structure of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound, PDB code: ... Arsenic in PDB 1p6l: Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-2,4- L-Diaminobutyric Amide Bound. ...

http://arsenic.atomistry.com/pdb1p6l.html

... amide is a substrate source of NO synthase in the gastropod nervous system, Cell Tissue Res. 325:567-575., 2006. ... Rőszer T., Kappelmayer J., Basnakian, G.A., Bánfalvi, G.:: The neuropeptide FMRF amide can protect cells against cell death in ... Rőszer T., JeneiZs., Gáll T., Czimmerer Zs., Serfőző Z., Elekes K., Bánfalvi, G.: A possible stimulatory effect of FMRF amide ... Changes in the expression and distribution of the inducible and endothelial nitric oxide synthase in mucosal biopsy specimens ...

http://nyilvanos.otka-palyazat.hu/index.php?menuid=930&num=42762

6.3.1 Acid ammonia (or amine) ligases (amide synthases). 6.3.1.4 aspartate-ammonia ligase (ADP-forming) ...

https://brenda-enzymes.org/all_enzymes.php?ecno=6.3.1.4&table=Application

... coding for a novel multidomain polyketide synthase that is essential for the production of zeamine, a novel polyamino-amide ... Zhou, J.; Zhang, H.; Wu, J.; Liu, Q.; Xi, P.; Lee, J.; Liao, J.; Jiang, Z.; Zhang, L. A Novel Multidomain Polyketide Synthase ... Piel, J. Biosynthesis of Polyketides by Trans-AT Polyketide Synthases. Nat. Prod. Rep. 2010, 27, 996-1047. [Google Scholar] [ ... This area of the D s0432-1 chromosome contained 13 ORFs annotated as polyketide synthase modules and acyl carrier proteins and ...

https://www.mdpi.com/1424-2818/5/4/824

Carbamoyl-Phosphate Synthase (Ammonia) * Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor [D08.811.464.259.400] ... Peptide Synthases - Preferred Concept UI. M0016235. Scope note. Ligases that catalyze the joining of adjacent AMINO ACIDS by ... Peptide Synthases Entry term(s). Acid Amino Acid Ligases Acid-Amino-Acid Ligases Ligases, Acid-Amino-Acid Peptide Synthetases ...

https://decs.bvsalud.org/en/ths/resource/?id=10646&filter=ths_exact_term&q=PEPTIDE+SYNTHASES

Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/ ... Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Aggarwal, A., Parai, M. K., Shetty, N., Wallis ...

https://discovery.dundee.ac.uk/en/organisations/drug-discovery-unit/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle&ordering=type&descending=false&page=1

... along with possible inhibition of DNA synthesis through the inhibition of thymidylate synthase. It is concluded that the amide ... The aim of this study was to verify the antifungal activity and the mechanism of action of the synthetic amide 2-chloro-N- ... In this way, riparins, a class of alkaloids that contain an amide group, are promising antifungal compounds. In this study, we ... The aims of this study were to evaluate the effects of the synthetic amide 2-chloro-N-phenylacetamide (A1Cl) against strains of ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Barbosa-Filho,+Jos%C3%A9+Maria

Synthesis of chiral alpha-hydroxy amides by two sequential enzymatic catalyzed reactions. Applied Microbiology and ... De repression of valine sensitive aceto hydroxy acid synthase ec 4.1.3.18 by threonine alpha keto butyrate or iso leucine in ... Regulation of synthesis of the aceto hydroxy acid synthase i iso enzyme in escherichia coli k 12. Biochimica et Biophysica Acta ... Substrate Range of Acetohydroxy Acid Synthase I from Escherichia coli in the Stereoselective Synthesis of a-Hydroxy Ketones. ...

https://eurekamag.com/research/006/250/006250481.php

Research advances in carboxylic acid amide fungicides[J]. Chin J Pestic Sci, 2010, 12(1): 1-12. doi: 10.3969/j.issn.1008- ... Multiple mutations in the predicted transmembrane domains of the cellulose synthase 3 (CesA3) of Phytophthora capsici can ... Resistance mechanism to carboxylic acid amide fungicides in the cucurbit downy mildew pathogen Pseudoperonospora cubensis[J]. ... Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, ...

http://nyxxb.cn/cn/article/doi/10.16801/j.issn.1008-7303.2022.0109

Gene expression of asparagine synthases (AS) class I and II and aspartate amino transferases (AAT) enzymes is shown for the ... these two amino acids are indistinguishable due to acid-enabled hydrolysis of the amide group from asparagine during protein ... Gene expression of asparagine synthases (AS) class I and II and aspartate amino transferases (AAT) enzymes is shown for the ... Two key genes for ammonium assimilation in plants are asparagine synthases (AS) and aspartate amino transferases (AAT), both of ...

https://www.mdpi.com/2218-1989/9/6/114

H (Glutamine synthase inhibitors). *I (DHP synthase inhibitors). *K1 (Dinitroanilines and others) ... C2 (Ureas and amides). *C3 (Nitriles and others). *D (Bipyridiliums). *E (PPO inhibitors) ...

https://weedscience.com/summary/HRACPoster.aspx

Farnesyl Diphosphate Synthase *Farnesyltransferase *Fatty Acid Amide Hydrolase *Fatty Acid Synthase *Uncategorized ...

http://www.exposed-skin-care.net/2018/11/20/background-prokineticin-2-pk2-manifestation-is-upregulated-in-mice-with-collagen-induced/

We tested the hypothesis that inducible isoform of nitric oxide synthase (iNOS)-derived nitric oxide (NO) inhibits oxygen ... Suzuki Y, Deitch EA, Mishima S, Lu Q, Xu D 2000 Inducible nitric oxide synthase gene knockout mice have increased resistance to ... lysine-5-tetrazole-amide, a selective iNOS inhibitor, in rats. J Pharm Sci 93: 1229-1240 ... Deitch EA, Shorshtein A, Houghton J, Lu Q, Xu D 2002 Inducible nitric oxide synthase knockout mice are resistant to diet- ...

https://www.nature.com/articles/pr200697?error=cookies_not_supported&code=5030ac1d-a012-4308-9a6c-dd12a21a9885

endothelial nitric oxide synthase,"Proceedings of the National. Academy of Sciences of the United States of America, vol. 104, ... amide mononucleotide supplementation reverses vascular. dysfunction and oxidative stress with aging in mice,"Aging ... inducible nitric oxide synthase (iNOS), and ciclooxigenase-2 (COX-2) at mRNA, protein and activity levels. Although ROS, NO and ... regulates the expression of endothelial nitric oxide synthase (eNOS) and manganese superoxide dismutase (MnSOD) and activates ...

https://www.researchgate.net/publication/316726908_Sirt1_Inhibits_Oxidative_Stress_in_Vascular_Endothelial_Cells

prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. ... prostamide F2α = (5Z,9α,11α,13E,15S)-9,11,15-trihydroxy-N-(2-hydroxyethyl)prosta-5,13-dien-1-amide. prostaglandin H2 = (5Z,9α, ... prostamide/prostaglandin F2α synthase. Reaction:. thioredoxin + (5Z,9α,11α,13E,15S)-9,11-epidioxy-15-hydroxy-prosta-5,13- ... Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Brain Res. ...

https://www.enzyme-database.org/query.php?ec=1.11.1.20

Nitrile hydratasees for synthesis of amides from nitriles. Grill, B., Schwab, H., Pogorevcnik, U., Glänzer, M., Reicher, K., ... Sucrose synthase: a unique glycosyltransferase enroute to biocatalytic process development. Schmoelzer, K., Gutmann, A., Lepak ... Sialic acid aldolase and synthase compared in optimized multi-enzyme cascade production of 3-sialyllactose. Schelch, S., Gross ... Complex oxidoreductive transformations in glycobiology: Characterization of human UDP-xylose synthase 1. Eixelsberger, T. & ...

https://graz.pure.elsevier.com/en/organisations/institute-of-biotechnology-and-biochemical-engineering-6510/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontoconference%2Fposter

FAAH (Fatty acid amide hydrolase) Ca2+/calmodulin-dependent kinase (CaMK) Acetylcholinesterase (AChE or acetylhydrolase) ... NO Synthase Cyclooxygenase (COX) Aryl Hydrocarbon Receptor Interleukin-1 receptor-associated kinase (IRAK) PD-1/PD-L1 ... ATP Synthase Chloride Channel BCRP(breast cancer resistant protein) Protein Tyrosine Kinase/RTK FGFR (Fibroblast growth factor ... Glycogen synthase kinase 3 (GSK-3) PI3K (Phosphoinositide 3-kinase) Akt/PKB (Protein kinase B) PDK-1 (phosphoinositide ...

https://www.anjiechem.com/search/cid/250.html

1992) 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem, ... 2003) Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B ...

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1298

Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. (atomistry.com)

Changes in the expression and distribution of the inducible and endothelial nitric oxide synthase in mucosal biopsy specimens of inflammatory bowel disease , Scand. (otka-palyazat.hu)
A possible stimulatory effect of FMRF amide on neuronal nitric oxide (NO) production in the central nervous system Helix lucorum L. , Brain Behav. (otka-palyazat.hu)
We tested the hypothesis that inducible isoform of nitric oxide synthase (iNOS)-derived nitric oxide (NO) inhibits oxygen consumption (Vo 2 ) in human intestine resected for necrotizing enterocolitis (NEC). (nature.com)
The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. (testosteroneanabolicsteroid.com)

One CAA member mandipropamid was proven to focus on the pathway of cell wall structure synthesis by inhibiting the CesA3 cellulose synthases [19]. (gasyblog.com)
Synthesis of nikkomycin analogue library by combinatorial synthesis on solid support and evaluation of their enzyme inhibitory activity against Candida albicans chitin synthases are described. (heterocycles.jp)

alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length. (cathdb.info)
2003) Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors. (guidetopharmacology.org)
1992) 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. (guidetopharmacology.org)

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. (bvsalud.org)
It consists of three components-ligands, including 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamide (AEA or anandamide), receptors, such as cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), and the metabolizing enzymes-fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). (encyclopedia.pub)

Restoring the production of molecules such as endothelialnitric oxide synthase and prostaglandin or inhibiting in?ammatory reactions byusing AAV-mediated gene transfer may help restore normal vascular function andprevent vein graft disease [ 40 buy generic Misoprostol online 41]. (williampeak.com)

An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489. (genome.jp)

A series of N -nitro acid amide derivatives compounds were synthesized based on the active site of target acetohydroxyacid synthase (AHAS, EC: 2.2.1.6) enzyme. (hindawi.com)
Twenty-four N -nitro acid amide derivatives compounds were synthesized, and all the target compounds were subject to biological activity tests against AHAS enzyme and herbicidal activity tests against Amaranthus mangostanus L. and Sorghum sudanense . (hindawi.com)

A radioenzymatic assay for the activity of acetohydroxy acid synthase [from Salmonella typhimurium] on 1 of its substrates, .alpha. (eurekamag.com)
Salmonella typhimurium mutants with altered glutamate dehydrogenase and glutamate synthase activities. (microbiologyresearch.org)

Pyrimorph (Z)-3-[(2-chloropyridine-4-yl)-3-(4-tert-butylphenyl)-acryloyl] morpholine is a novel systemic antifungal agent that belongs to the family of carboxylic acid amide (CAA) fungicides [14] whose members include mandipropamid dimethomorph flumorph and valinine derivatives. (gasyblog.com)

In vitro investigations using the highly-reducing fungal polyketide synthase CazF revealed that its methyltransferase domain accepts the nonnatural cofactor propargylic Se -adenosyl-L-methionine and can transfer the propargyl moiety onto its growing polyketide chain. (cdc.gov)

Unlike M2, PT-141 lacks C-terminal amide molecules. (testosteroneanabolicsteroid.com)

Radical SAM superfamily, N-terminal domain of lipoyl synthase of Radical_SAM family [Interproscan]. (ntu.edu.sg)

To further explore a series of novel structural potential compounds as excellent herbicides, an idea that joined the different trisubstituted N -nitro aniline and benzamides, cinnamic amides together were performed in this study. (hindawi.com)
In this way, riparins, a class of alkaloids that contain an amide group, are promising antifungal compounds. (bvsalud.org)

The aim of this study was to verify the antifungal activity and the mechanism of action of the synthetic amide 2-chloro-N-phenylacetamide against Aspergillus niger strains and toxicity. (bvsalud.org)
Mutant strains lacking NADP-GDH and glutamate synthase (Gdh − Glt − ) required glutamate for growth. (microbiologyresearch.org)

In addition to freestanding methyltransferases, methyltranserase (MT) domains can also be found within polyketide synthases (PKS) where they catalyze the α-methylation of a growing β-keto polyketide chain using 1 as the methyl-donating cofactor. (cdc.gov)

Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. (justia.com)
Growth of Pseudomonas aeruginosa mutants lacking glutamate synthase activity. (microbiologyresearch.org)

9. Scorziello A, Meucci O, Calvani M, Schettini G. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells. (lifeextensionvitamins.com)

A strategy for introducing structural diversity into polyketides by exploiting the promiscuity of an in-line methyltransferase domain in a multidomain polyketide synthase in reported. (cdc.gov)

We identify the responsible enzyme as fatty acid amide hydrolase (FAAH) and establish how PM20D1 and FAAH engage in extensive non-additive interactions in vivo to regulate the levels of N-acyl amino acids cooperatively. (elifesciences.org)
Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT). (semanticscholar.org)
Early kinetic studies utilizing mutants and transgenic plants that over-accumulate lysine have indicated that the major step for the regulation of lysine biosynthesis is at the enzyme dihydrodipicolinate synthase. (scielo.br)
The enzyme, characterized from the bacterium Staphylococcus aureus , catalyses the last step in the biosynthesis of the siderophore staphyloferrin A . It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). (enzyme-database.org)
Nitric oxide is produced by the following NO synthase (NOS) enzymes: neuronal NOS (nNOS) and endothelial NOS (eNOS,) which are constitutive enzyme isoforms, [ 76 , 77 ] and inducible NOS (iNOS), which is overexpressed in airway epithelial and inflammatory cells of patients with asthma. (medscape.com)
The amide of Gln undergoes nucleophilic assault by the side chain thiolate of Cys1 to generate a hemithioaminal which decomposes to a γ-glutamyl-S-enzyme varieties and nascent NH3. (colinsbraincancer.com)
Fatty-acid amide hydrolase (FAAH) may be the main enzyme in charge of degradation of anandamide, an endocannabinoid. (paccon2016.com)
Nitric oxide is synthesized in biological tissues by an enzyme called nitric oxide synthase (NOS) which uses NADPH and molecular oxygen to oxidize L-arginine to citrulline and nitric oxide. (allindianpatents.com)
We previously discovered that the mitochondrial AAA+ protein unfoldase ClpX (mtClpX) activates the initiating enzyme for heme biosynthesis, 5-aminolevulinic acid synthase (ALAS), by promoting cofactor incorporation. (elifesciences.org)
Hence, it appears another anti-inflammatory therapy ought to be targeted through a particular prostanoid receptor or a prostanoid synthase enzyme downstream of COX-2, than universal stop of whole COX-2 cascade3 rather, 4, 17C19. (clarkfrancis.com)
Hydrogen sulfide (H 2 S) is another "gas transmitter": it is generated from cyst(e)ine by the enzyme cystathionine β-synthase. (mhmedical.com)

Four new conformationally restricted analogues of a potent and selective neuronal nitric oxide synthase inhibitor, L-nitroargininyl-L-2,4- diaminobutyramide (1), have been synthesized. (uthscsa.edu)
Analogue 4 has only one-third the potency and one-half to one-third the selectivity of 2 against iNOS (inducible nitric oxide synthase) and eNOS (endothelial nitric oxide synthase), respectively. (uthscsa.edu)
The overproduction of nitric oxide during the biological response to inflammation by the nitric oxide synthase (NOS) enzymes have been implicated in the pathology of many diseases. (infona.pl)
They have shown that chronic oral administration of 1 mg/kg of MH in mice strongly ameliorates LPS-induced memory impairment via inhibition of nuclear factor kappa B (NF-κB) and the gene expression of inducible nitric oxide synthase and cyclooxygenase-2. (biomedcentral.com)
The invention relates to a series of N-heterocyclic compounds and derivatives useful as inhibitors of nitric oxide synthase (NOS) and to methods of therapy for various diseases employing those compounds. (allindianpatents.com)
Nitric oxide synthase (NOS) exists in at least three isoforms, which fall into two primary, categories: constitutive and inducible. (allindianpatents.com)
The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. (peptide-hormone.com)
Gene expression and functional studies showed that IL-10, inducible nitric oxide synthase, and CCR2 in monocytes are essential buy RSL3 buy RSL3 for neuroprotection. (og-l002.com)
Nitric oxide (NO) is generated from arginine by NO synthase, which is stimulated by activation of postsynaptic NMDA receptors and increases in cellular Ca 2+ levels. (mhmedical.com)

Anticandidal activity of mbti personality tested amides has correlated with their inhibitory activity of glucosamine-6-phosphate synthase in cell free sensory issues from Candida albicans. (filmywap2017.xyz)

Analytical size columns (2.1 to 4.6 mm diameter) traditionally utilized for HPLC separation of native oligosaccharides include porous graphitized carbon (PGC), amine/amide-based, and anion-exchange press as stationary phases[22C27]. (rectalcancersite.com)

The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). (semanticscholar.org)
The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). (semanticscholar.org)
Antiproliferative potential of the obtained conjugates was investigated in xiapex and MPA amides with threonine methyl. (filmywap2017.xyz)
Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. (ebi.ac.uk)
The cell may genetically modified to express methyl formate synthase, methanol dehydrogenase and/or hydrolytic dehalogenase at levels higher than a cell of the same species that is not genetically modified. (justia.com)
Nicotinamide had gene-specific effects on the methylation of CpG sites within the promoters and the expression of hepatic genes tested that are responsible for methyl transfer reactions (nicotinamide N -methyltransferase and DNA methyltransferase 1), for homocysteine metabolism (betaine-homocysteine S -methyltransferase, methionine synthase and cystathionine β-synthase) and for oxidative defence (catalase and tumour protein p53). (cambridge.org)

In vitro, recombinant PM20D1 functions as a bidirectional N-acyl amino acid synthase/hydrolase, catalyzing the biosynthesis of N-acyl amino acids from free fatty acids and free amino acids, as well as the reverse hydrolysis reaction. (elifesciences.org)
In vivo reconstitution using Streptomyces coelicolor (CH999) revealed that the asparagine synthase homolog OxyD is necessary and sufficient for the biosynthesis and incorporation of the malonamate starter unit. (confex.com)
Resumen en inglés From 1960 to the end of the XX century, efforts from different laboratories were done to understand the regulation of eicosanoids biosynthesis and metabolism. (worldwidescience.org)
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis. (kegg.jp)

Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 (peptidase M20 domain containing 1). (elifesciences.org)
The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. (nih.gov)
When central sensitization was set up, FAAH KO mice shown elevated degrees of anandamide, various other fatty-acid JWS amides, and endogenous TRPV1 agonists in both paw epidermis and lumbar spinal-cord in accordance with wild-type mice. (paccon2016.com)

As a result we synthesized and screened a little collection of tertiary amide derivatives of indomethacin, that have a reduced capability to ion-pair and hydrogen connection with Arg-120 and Tyr-355. (cylch.org)

Cellular functions affected by the sphingomyelin synthase (D'Angelo et al . (creative-proteomics.com)

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. (nih.gov)
Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. (nih.gov)
Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. (nih.gov)

The amide synthases are predicted to catalyse intramolecular amide bond formation and creation of cyclic molecules, e.g. geldanamycin. (nih.gov)

Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. (filmywap2017.xyz)

Lack of conservation of the CoA binding cleft residues of M. marinum NAT suggests the amide synthase reaction mechanism does not involve a soluble CoA intermediate during amide formation and ring closure. (nih.gov)
The present invention relates to variants with improved activity in an amide-bond reaction. (justia.com)
The second hydrogen abstraction was related with the chemistry reaction between amide group and hydroxyl radical to give N-acetyl-p-benzoquinone imine (NAPQI). (ufpa.br)

Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. (semanticscholar.org)

Using an activity-guided biochemical approach, we report the molecular identification of fatty acid amide hydrolase (FAAH) as a second intracellular N-acyl amino acid synthase/hydrolase. (elifesciences.org)
Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. (vanderbilt.edu)
Fatty acid amide hydrolase deficiency limits early pregnancy events. (vanderbilt.edu)
In the sphingomyelin molecule, the amino group of sphingosine forms an amide bond with the fatty acid, and the hydroxyl group of sphingosine is attached to phosphatidylcholine . (creative-proteomics.com)
Nicotinic acid was discovered to be straight tethered to the buy Wortmannin ion (assumed to end up being Zn2+ in the survey), its carboxylate group getting hydrogen-bounded to the main-chain amides of cis-Ala155 and Cys159 forming the oxyanion hole in AbPncA (corresponding to Ala134 and Cys138 in MtPncA). (stemcellethics.net)
N-Acetyl-D-Glucosamine is the N-acetyl derivative of glucosamine.Chemically it is an amide between glucosamine and acetic acid. (chemicalbook.com)

[ 12 ] [ 13 ] The octanoate is transferred from a thioester of acyl carrier protein to a amide of the lipoyl domain by an octanoyltransferase. (zubiaga.org)

Amide-modified farnesyl cysteine analogs (AMFCs)15,16 had been synthesized and analyzed inside our laboratories to research tolerances and particular requirements upstream from the prenylcysteine. (thetechnoant.info)
Cinnamic amides might become Michael acceptors and create a potential risk NSC 87877 for medication advancement, researchers also developed several amide analogs seeing Rabbit Polyclonal to Cytochrome P450 1B1 NSC 87877 that EP2 antagonists so. (clarkfrancis.com)

Permetrexed is easily converted polyglutamates which inhibit thymidylate synthase, dihydrofolate reductase, and lysine amide ribonucleotide transformylase. (pharmacology2000.com)
As a cofactor it is covalently bound via and amide bond to a specific lysine residue of lipoyl domains. (zubiaga.org)

In vitro folding studies of several proteins revealed the formation, within 2-4 msec, of transient intermediates with a large far-UV ellipticity but no amide proton protection. (pasteur.fr)

glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase. (expasy.org)
L-glutamate synthase. (expasy.org)

To solve the contradiction between the secondary structure contents estimated by these two methods, we characterized the isolated C-terminal fragment F2 of the tryptophan synthase beta 2 subunit. (pasteur.fr)
vacuolar ATP synthase subunit C (VATC) / V-ATPase C. (ntu.edu.sg)

With assignment of methods is the ability to measure couplings without scaling the backbone amide signals being a prerequisite for any peak positions or altering the narrow line widths character- detailed analysis of protein structure and dynamics, the istic of TROSY spectra. (nih.gov)

The sulfur centers are inserted into the 6th and 8th carbons of octanoate via the a radical s-adenosyl methionine mechanism, by lipoyl synthase. (zubiaga.org)

Amide synthase genes in the streptomyces are also nat homologues. (nih.gov)

Yuliya Birman: "Investigation of Charged Residues in the Active Site of Isopropylmalate Synthase in Mycobacterium Tuberculosis. (ua.edu)

Tetracyclines are aromatic polyketides that are biosynthesized by bacterial type II polyketide synthases (PKS). (confex.com)
One of the distinguishing features of tetracyclines is the presence of an amide unit at one terminus of the polyketide backbone. (confex.com)

glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP). (expasy.org)

These two substances participate in a cinnamic amide chemical substance class, where among amide (CONH2) proton is normally substituted with a two carbon linker with an indole band by the end. (clarkfrancis.com)

Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. (springeropen.com)

tumbling proteins measurements are often restricted to the The primary advantage of the ARTSY method over other backbone amide 1H-15N RDC, 1DNH. (nih.gov)

The mechanism is similar to that of argininosucccinate synthase. (libretexts.org)

Amide Bond Formation in Nonrib. (uni-marburg.de)

Chemicals and Drugs6

Phenomena and Processes1

Information Science2

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. (1/66)

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (2/66)

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. (3/66)

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. (4/66)

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. (5/66)

Stable ammonia-specific NAD synthetase from Bacillus stearothermophilus: purification, characterization, gene cloning, and applications. (6/66)

Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. (7/66)

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. (8/66)

Amide Synthases

Amides

Polyketide Synthases

Alkyl and Aryl Transferases

Chitin Synthase

Molecular Sequence Data

Amino Acid Sequence

Amidohydrolases

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. (1/66)

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891. (2/66)

Cloning, overexpression, and purification of novobiocic acid synthetase from Streptomyces spheroides NCIMB 11891. (3/66)

Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata. (4/66)

A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi. (5/66)

Stable ammonia-specific NAD synthetase from Bacillus stearothermophilus: purification, characterization, gene cloning, and applications. (6/66)

Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. (7/66)

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. (8/66)

Properties of trypanothione synthetase from Trypanosoma brucei<...

trypanothione synthetase Summary Report | CureHunter

What does nads mean? nads Definition. Meaning of nads. OnlineSlangDictionary.com

Ancestry Refines New Ancestor Discoveries (NADs) | DNAeXplained - Genetic Genealogy

Domain Architecture in a Homodimeric Multi-substrate Enzyme

NAD Synthetase from B. subtilis, Recombinant - Creative Enzymes

nards/nads

Krauth-Siegel, Luise Heidelberg - SPP 1710 Home

NYC infant mortality rate Archives - QNS.com

Leukemia & Lymphoma Society Archives - QNS.com

Thursday Smackdown

Nigro lactating milk - hq clips

Test Injection and SERM - T Replacement - Forums - T Nation

ONLINE FORM FOUR NECTA BIOLOGY YEAR 2008 REVIEW (QNS. & ANS.)

DVDizzy.com • View topic - Hotmail problems?

HighSpots.com: ECW Hardcore TV Complete Set Volume 2 DVD-R

HighSpots.com: ECW Hardcore TV 75-78 DVD-R

SMART: Pfam domain NAD synthase

Glutathionylspermidine Disulfide - DrugBank

Gene Expression: Genome-wide association studies in the UK

Nads Mens Hair Removal Strip 20 NZ Prices - PriceMe

Q747Q5 | nadD | Probable nicotinate-nucleotide adenylyltransferase | Druggability | Cancer

What does QNS stand for?

Retinoid at Pharmacy Direct - Buy Direct & Save! SHOP NOW!

Magnesium Phosphinate - Drugs.com

Plus it

Commerce Commission ends K-Y and Durex trys - Lexology

2021 NADE AWARDS CRITERIA | NADE

Watch Hd Shay fox cum in me not on my couch - quality movies

testicular atrophy? - AnabolicMinds.com

What it takes for forced induction and much more... - Page 19 - Mustang Evolution

ReCreate QNS - Neighborhood News - New York - DNAinfo

Korngold Sérénade Symphonique Op 39 - Sextuor Op 10 Rohde - Cpo555138 - Low Price - by

Help Us Make FDA Live Up to Its Compassionate Use Rule! | The Alliance for Natural Health

MY STORY OF FRACKNG FECES UP (probably) | GBAtemp.net - The Independent Video Game Community

Dog cant pee after being hit by a car. | Ask A Vet

Games: SpiderMan and Venom: Maximum Carnage | MegaGames

Games: SpiderMan and Venom: Maximum Carnage | MegaGames

Sodium phosphinate - Manufacturer - Producer - PSL176311YH

Benefits of Shabad Guru | 3HO Foundation

3O35 | Genus

JACKET WITH STUDS - Ánade

Driving simulator seeks participants for contact lens study

nads urban dictionary

At A Glance

Nads Natural Brazilian & Bikini Kit | Ulta Beauty

Nads - Bikini & Underarm Wax Strips Reviews | beautyheaven

Smiling sombrero Sandoval trys passing resolution to silence commentator! | No Compromise When Youre...

National Association for Down Syndrome | Self-Advocates In Action Zoom party!

MENINGITIS FEAR OVER SICK QNS. SCHOOLKID | New York Post

2 Tikes Under 2 & the Caboose!: What day is it???

Sodium Phosphinate | Solvay

Sequence Similarity - 1HOS: INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2-SYMMETRIC PHOSPHINATE...

Calcium phosphinate - Registration Dossier - ECHA

State My Name by Nadd Wellgreen | PDF, EPUB, FB2, DjVu, audiobook, MP3, TXT, ZIP | liyou.newbkdlthere.online

Boston kinderpet - wit

Lac operon

Weather History for Hamilton Island, Australia | Weather Underground

Weather History for Oakey, Australia | Weather Underground

FSSweden Moddtävling 2016 - Nyheter - FSSweden

Z-Ala-Lys-Arg-AMC › PeptaNova

Charlie Sheen: Im still alive, which is pretty cool - Piers Morgan - CNN.com Blogs

Vibriobactin

4-methyleneglutamate-ammonia ligase