Ameloblasts
Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)
Amelogenesis
Enamel Organ
Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.
Dental Enamel
A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)
Incisor
Amelogenin
Tooth Calcification
Odontogenesis
Tooth Germ
Molar
The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)
Dental Enamel Hypoplasia
An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.
Amelogenesis Imperfecta
Matrix Metalloproteinase 20
Fluorosis, Dental
A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)
SLC4A Proteins
Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).
Plastic Embedding
Dentin
Dentinogenesis
The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)
Tooth Crown
The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)
Dental Pulp
Claudin-1
Fluorides
Mandible
Anion Transport Proteins
Proton Pumps
Antiporters
Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)
Dry dissected rat incisor ameloblasts studied in the scanning electron microscope show remarkable specializations of their lateral surfaces. Four or five cycles of a change from a surface with longitudinal gutterlike folds associated with large intercellular spaces, to one with microvilli and reduced intercellular spaces, are found along the length of the lower incisor maturation zone. It is argued that these changes indicate cyclical activity in maturation ameloblasts. (+info)Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)
Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative ligand. Second, we identified a survival defect in mutant epithelial cells that could be rescued by exogenous laminin 5, collagen, or an antibody against integrin alpha6beta4, suggesting that signaling through beta1 or beta4 integrins is sufficient for survival. Third, we detected abnormalities in ameloblast differentiation in developing mutant incisors indicating that events downstream of adhesion are affected in mutant animals. These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium. (+info)Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)
About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Northern analysis of RNA from mouse embryos at embryonic days 7, 11, 15, and 17 showed a predominant 4.5 kb band in all stages. By in situ hybridization, Fanca transcripts were found in the whisker follicles, teeth, brain, retina, kidney, liver, and limbs. There was also stage-specific variation in Fanca expression, particularly within the developing whiskers and the brain. Some tissues known to express Fancc (eg, gut) failed to show Fanca expression. These observations show that (1) Fanca is under both tissue- and stage-specific regulation in several tissues; (2) the expression pattern of Fanca is consistent with the phenotype of the human disease; and (3) Fanca expression is not necessarily coupled to that of Fancc. The presence of distinct tissue targets for FA genes suggests that some of the variability in the clinical phenotype can be attributed to the complementation group assignment. (+info)Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)
The continuously growing mouse incisor is an excellent model to analyze the mechanisms for stem cell lineage. We designed an organ culture method for the apical end of the incisor and analyzed the epithelial cell lineage by 5-bromo-2'-deoxyuridine and DiI labeling. Our results indicate that stem cells reside in the cervical loop epithelium consisting of a central core of stellate reticulum cells surrounded by a layer of basal epithelial cells, and that they give rise to transit-amplifying progeny differentiating into enamel forming ameloblasts. We identified slowly dividing cells among the Notch1-expressing stellate reticulum cells in specific locations near the basal epithelial cells expressing lunatic fringe, a secretory molecule modulating Notch signaling. It is known from tissue recombination studies that in the mouse incisor the mesenchyme regulates the continuous growth of epithelium. Expression of Fgf-3 and Fgf-10 were restricted to the mesenchyme underlying the basal epithelial cells and the transit-amplifying cells expressing their receptors Fgfr1b and Fgfr2b. When FGF-10 protein was applied with beads on the cultured cervical loop epithelium it stimulated cell proliferation as well as expression of lunatic fringe. We present a model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression and, thereby, has a central role in coupling the mitogenesis and fate decision of stem cells. (+info)Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)
Dentin sialoprotein and dentin phosphoprotein are non-collagenous proteins that are cleavage products of dentin sialophosphoprotein (DSPP). Although these two protein products are believed to have a crucial role in the process of tooth mineralization, their precise biological functions and the molecular mechanisms of gene regulation are not clearly understood. To understand such functions, we have developed a transgenic mouse model expressing a reporter gene (lacZ) under the control of approximately 6 kb upstream sequences of Dspp. The transgenic fusion protein was designed to reside within the cells to facilitate the precise identification of cell type and developmental stages at which the Dspp-lacZ gene is expressed. The results presented in this report demonstrate: (a) the 6 kb upstream sequences of Dspp have the necessary regulatory elements to direct the tissue specific expression of the transgene similar to endogenous Dspp, (b) both odontoblasts and ameloblasts exhibit transgene expression in a differentiation dependent manner, and (c) a differential regulation of the transgene in odontoblasts and ameloblasts occurs during tooth development and mineralization. (+info)Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)
The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family, in the developing rat molar tooth was determined by in situ hybridization. At the initiation stage of tooth development, PACE4 mRNA was weakly expressed in the dental lamina, whereas the mesenchymal cells intensely expressed the PACE4 transcript. At the bud stage, high-level expression of PACE4 mRNA was found in the dental epithelium and condensed dental mesenchyme. Its expression became more localized in the differentiating ameloblasts during cap and early bell stages. In the newborn rats, PACE4 mRNA was localized in the ameloblasts and odontoblasts, but its expression became weaker with advancing development, showing apparent association with the differentiation and establishment of functional ameloblasts and odontoblasts. These expression patterns of PACE4 were very similar to those of several bone morphogenetic proteins (BMPs) reported previously. Because BMPs, which are primarily involved in the morphogenesis in tooth formation, are synthesized as inactive precursors and activated by limited proteolysis at the consensus Arg-X-X-Arg maturation site, the present observations suggest that PACE4 is possibly a candidate proBMP convertase that acts during tooth formation. (+info)Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)
Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histological examinations of individual organs in Sp3(-/-) mice show a pronounced defect in late tooth formation. In Sp3 null mice, the dentin/enamel layer of the developing teeth is impaired due to the lack of ameloblast-specific gene products. Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy. (+info)Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)
Previous studies have demonstrated the presence of calbindin D28k in the ameloblasts derived from the inner enamel epithelium. The occlusal surfaces of the rodent molars partly lack the enamel covering, which is referred to as enamel-free area (EFA). In the present study, we compared the immunohistochemical localization of calbindin D28k-like immunoreactivity (CB-LI) in the cells at the EFA (EFA cells) and ameloblasts of the rat molar teeth at the light microscopic level. CB-LI was strong in the ameloblasts of the presecretory through the protective stages, while it was faint at the late secretory to transitional stages. However, some mature ameloblasts lacked the immunoreactivity. On the other hand, the majority of EFA cells showed distinct polarization and elongation that were absent in few cells at the early stage of EFA formation. At all stages, the EFA cells adjacent to the ameloblasts showed CB-LI, however, some cells adjacent to the mature ameloblasts lacked the reaction. Intensive CB-LI was demonstrated in EFA cells at the reduced enamel epithelium. These immunohistochemical findings suggest EFA cells have cytochemical properties similar to those of ameloblasts. (+info)
HKU Scholars Hub: Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS
Early Ameloblasts Development in the Dental Enamel - LifeMap Discovery
Quintessence Publishing
Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-Aldrich
Scientists uncover secret to sharp teeth | EurekAlert! Science News
New connections: Protein trafficking for strong bones and teeth | Science Signaling
Alan Brymer on How To Run a Successful Real Estate Business Monday, August 4, 2008
Incisor - wikidoc
Gene expression in tooth: references
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Gene expression in tooth: references
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Amphimoea
Ameloblast
Distal terminal bars are junctional complexes that separate the Tomes' processes from ameloblast proper. Ameloblasts are ... Initially the preameloblasts will differentiate into presecretory ameloblasts and then into secretory ameloblasts which lay ... Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the ... Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross ...
Index of oral health and dental articles
Ameloblast • Ameloblastic fibroma • Ameloblastin • Ameloblastoma • Amelogenesis • Amelogenesis imperfecta • Amelogenin • ...
Ameloblastoma
The ameloblasts cells can be less prominent. Large cysts up to a few centimetres in diameter can be found. In follicular type, ... The most common follicular type has an outer arrangement of columnar or palisaded ameloblasts-like cells and inner zone of ... Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium (ameloblasts, or outside portion, of the teeth ... Resemble a fibro-osseous lesion with no obvious ameloblasts whilst dominated by dense collagenous tissue (desmoplastic). In one ...
Tooth enamel
Thus, each band on the enamel rod demonstrates the work/rest pattern of the ameloblasts that generally occurs over a span of a ... Both ameloblasts (the cells which initiate enamel formation) and Tomes' processes affect the crystallites' pattern. Enamel ... When this first layer is formed, the ameloblasts move away from the dentin, allowing for the development of Tomes' processes at ... At some point before the tooth erupts into the mouth, but after the maturation stage, the ameloblasts are broken down. ...
Amelogenesis
Ameloblasts must also be present for dentinogenesis to continue. A message is sent from the newly differentiated odontoblasts ... It is at this stage that a signal is sent from the newly differentiated ameloblasts back across the dentinoenamel junction (DEJ ... When this first layer is formed, the ameloblasts move away from the interface with dentin, allowing for the development of ... Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, ...
Human tooth development
Ameloblasts make enamel at the location of where the cusps of the teeth are located. Enamel grows outwards, away from the ... As the ameloblasts degenerate, a gingival sulcus is created.[citation needed] Frequently, nerves and blood vessels run parallel ... In summary, the layers in order of innermost to outermost consist of dentin, enamel (formed by IEE, or 'ameloblasts', as they ... Outside the dentin are the newly formed ameloblasts in response to the formation of dentin, which are cells that continue the ...
Enamel prism
Such is the case in both permanent and primary dentitions; the enamel prisms following the path of the ameloblasts[5]. In ... Relationships between enamel prism decussation and organization of the ameloblast layer in rodent incisors. The Anatomical ...
ODAM (gene)
Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ODAM odontogenic, ameloblast asssociated [sic]". Retrieved 2013-03-31. Moffatt P, Smith CE, Sooknanan R, et al. ( ...
BCL11B
Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast ... Research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly. ...
Tomes's process
More than one ameloblast contributes to a single prism. Tomes's processes are distinctly different from Tomes's fibers, which ... During the synthesis of enamel, the ameloblast moves away from the enamel, forming a projection surrounded by the developing ... Tomes's processes (also called Tomes processes) are a histologic landmark identified on an ameloblast, cells involved in the ... Tomes's processes are those projections and give the ameloblast a "picket-fence" appearance under a microscope. They are ...
Interrod enamel
All tooth enamel, including interrod enamel and enamel rods, is made by ameloblasts. However, interrod enamel is formed ...
TFIP11
... localizes to the apical secretory pole of mouse ameloblasts". J Biol Chem. 275 (29): 22284-92. doi:10.1074/jbc.M000118200. PMID ...
Ameloblastic fibroma
The bud-cap stage of normal development shows ameloblasts forming palisades of columnar cells adjacent to a starry-like, ... These proliferate and mature into ameloblasts and fibrous connective tissue (3), and ultimately teeth. Ameloblastic fibromas ...
Enamel organ
Ameloblast extension rate Duration of ameloblast extension Spreading rate of appositional termination. The appositional growth ... the secretory stage will end and they will transition into maturation stage ameloblasts. These ameloblasts will move down to ... A wave of ameloblasts will then differentiate from the cusp tip and move through the inner enamel epithelia down the slope of ... They are produced by the ameloblast in the bell stage of tooth development. As the crystals are long and closely packed, the ...
Human tooth
These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...
Tuftelin
2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 ... localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284-92. doi:10.1074/jbc ...
Dental anatomy
These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...
Odontogenic keratocyst
The basal cells are an indication of the odontogenic origin as they resemble pre-ameloblasts. The epithelium can separate from ...
Inner enamel epithelium
This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. These ... will differentiate into Ameloblasts which are responsible for secretion of enamel during tooth development. The location of the ...
Ameloblastin
This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not ...
Enamel pearl
Intradental enamel pearls may form during tooth formation, when ameloblasts are invaginated inside the developing dentin. Inner ... these fragments have the potential to develop into functional ameloblasts, which then deposit enamel onto the root surface, ...
Pitting enamel hypoplasia
This does not occur in other forms of enamel hypoplasia, such as linear and plane-form, in which all ameloblast activity is ... Each pit is linked to the ceasing of ameloblasts at a particular point in enamel formation. Sometimes, only a couple of ... but all types are associated with a reduction of enamel formation due to disruption in ameloblast production. One of the most ... ameloblasts stop forming enamel, leading to small PEH defects, with large pits forming when hundreds of these enamel-forming ...
Junctional epithelium
The ameloblasts also develop hemidesmosomes for the primary EA and become firmly attached to the enamel surface. However, the ... Before the eruption of the tooth and after enamel maturation, the ameloblasts secrete a basal lamina on the tooth surface that ...
Pangolin
"Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales". BMC ...
FAM83H
MMP20 is responsible for the breakdown of extracellular matrix and plays a role in tissue remodeling in ameloblasts. mutations ...
Enamel tufts
This is because they are formed by entrapment of odontoblast processes between ameloblasts prior to and during amelogenesis. ...
Molar incisor hypomineralisation
More recent evidence has suggested a relationship between respiratory diseases and oxygen shortage of the ameloblasts and MIH. ... due to interruption to the function of ameloblasts. Many factors have been suggested, such as genetics and medical problems ...
Calcifying odontogenic cyst
Ameloblast-like proliferation in the connective tissue and lumen of the cyst may be seen. The standard treatment of calcifying ... Additionally, focal areas of stellate reticulum like cells are seen and near the basement membrane ameloblast-like cells may be ...
Dentin dysplasia
... or differentiation are mainly due to atypical interaction between odontoblasts and ameloblasts. Histopathologically, deeper ...
Enamel hypocalcification
Local trauma or abscess formation can adversely affect the ameloblasts overlying a developing crown, resulting in enamel ...
Fluoride Action Network | Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts
RESULT: High fluoride concentration was associated with decreased ameloblast proliferation, elevated ameloblast apoptosis, and ... Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts. Author: Zhang Y, Zhang K, Ma L, Gu H, Li J, ... Micromolar fluoride alters ameloblast lineage cells in vitro.. Fluorosed enamel is caused by exposure to fluoride during tooth ... To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF ( ...
Frontiers | Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel...
Ameloblasts secrete enamel matrix proteins and Ca2+, and also regulate extracellular pH as the formation of hydroxyapatite ... Aims: Our aims were to optimize the culture conditions for the three-dimensional growth of ameloblast-derived HAT-7 cells and ... The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport- ... The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport- ...
THE ULTRASTRUCTURE OF AMELOBLASTS DURING MATRIX FORMATION AND THE MATURATION OF ENAMEL | Journal of Cell Biology | Rockefeller...
Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. During matrix ... THE ULTRASTRUCTURE OF AMELOBLASTS DURING MATRIX FORMATION AND THE MATURATION OF ENAMEL Edward J. Reith Edward J. Reith ... Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. During matrix ... In the most incisal region, the ameloblasts are further reduced in height. Distal processes are no longer present and fibrils ...
Ameloblasts | Profiles RNS
"Ameloblasts" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Ameloblasts" by people in this website by year, and whether " ... Below are the most recent publications written about "Ameloblasts" by people in Profiles. ...
Developmental Biology
G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. Journal of Biological ... Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell ameloblast-secreted enamel matrices ... Enamel mineralization occurs in a strictly synchronized manner along with ameloblast maturation in association with ion ...
The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts<...
The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ...
FAM83H gene: MedlinePlus Genetics
Shh and fluoride - PFPC Fluoride Education Project
Results Shh secretory ameloblasts in, odontoblasts expression. Shh expression in the experimental group was significantly ... The results of the study, the results of immunohistochemistry for the control rats ameloblasts smad3, shh expression is ... Conclusion: In the late incisor development,Shh might participate in the ameloblast and odontoblast differentiation as a ... Immunostaining for shh was detected in dental epithelium , oral epithelium, and ameloblasts. Shh was weakly expressed in ...
Pathology and Laboratory Science - Research output - the UWA Profiles and Research Repository
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss | Scientific Reports
Odontogenic ameloblast-associated protein) and dentin dysplasia targets (Dentin matrix acidic phosphoprotein 1). We tested if ... Reduction of odontogenic ameloblast-associated protein (Odam), encoding a secreted protein guiding early enamel formation, ... Odontogenic ameloblast-associated protein) and dentin dysplasia targets (Dentin matrix acidic phosphoprotein 1). We tested if ...
Human Dentin Matrix Acidic phosphoprotein 1 (DMP1) Protein (His tag), Recombinant | ABIN1691401
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Fluoride: Double-Edged Sword Implicated in Caries Prevention and in Fluorosis
Secretory ameloblasts. These are relatively resistant to the effects of acute fluoride exposure in comparison with early- and ... Maturation ameloblasts. Although maturation-stage enamel seems to be most sensitive to fluoride, there are remarkably few ... A single higher dose of fluoride (9 mg F/kg body weight) induces cyst formation by early-secretory ameloblasts in the cervical ... Cellular changes in secretory ameloblasts in vivo are reported only after the injection of high levels of fluoride. One or ...
Pesquisa | BVS Odontologia
Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. - Ozgene
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The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma...
Maturation stage ameloblastsSecretoryOdontoblastCellsMineralizationEpithelial cellSecrete enamelDifferentiationToothEpitheliumVivoMeSHFluorideTransitionalDistalRatsConcentrationsDentinStageTeethDentalFormationOdontoblastsEpithelialAnalyzing ameloblast differentiationAmelogenesisMaturationEnamel hypoplasiaTooth enamelAmeloblastinIncisorDental enamelCellularSecretionTissueMiceIncisorsMouseLayerStudy
Maturation stage ameloblasts2
- Enamel mineralization in the absence of maturation stage ameloblasts. (bvsalud.org)
- Histochemical X-gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside) staining demonstrated expression of beta-galactosidase in maturation stage ameloblasts. (ozgene.com)
Secretory3
- No X-gal staining was observed in secretory stage ameloblasts or in odontoblasts. (ozgene.com)
- In the secretory stage, ameloblasts are polarized columnar cells. (regencydentalgroupblog.com)
- These signs demonstrate that the ameloblasts have changed their function from production, as in the secretory stage, to transportation. (regencydentalgroupblog.com)
Odontoblast1
- DMP-1 is expressed in teeth particularly in odontoblast, ameloblast, and cementoblast. (antikoerper-online.de)
Cells10
- METHODS: We cultured and exposed rat ameloblast HAT-7 cells to various concentrations of fluoride and measured apoptosis with flow cytometry and intracellular Ca2+ changes using confocal microscopy, investigated the protein levels of GRP78, calreticulin, XBP1 and CHOP by western blotting, and their transcriptional levels with RT-PCR. (fluoridealert.org)
- Our aims were to optimize the culture conditions for the three-dimensional growth of ameloblast-derived HAT-7 cells and to test the effects of fluoride exposure on HAT-7 spheroid formation. (frontiersin.org)
- The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport-specific marker genes. (frontiersin.org)
- However, these primary ameloblast-like cells can be passaged only 3 times, and so have limited use in studies of ameloblast function. (frontiersin.org)
- The protein is found in several types of cells, including specialized cells called ameloblasts. (medlineplus.gov)
- The results were clas- effects on the ameloblast cells during the sified according to age and severity. (who.int)
- 2011 ) Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. (academictree.org)
- This is the first transcription factor ever found to control the formation and maturation of ameloblasts, which are the cells that secrete enamel. (healthjockey.com)
- Circadian clock genes are present in the ameloblasts, odontoblasts, and dental pulp cells. (bvsalud.org)
- Amelogenesis, or enamel formation, occurs after the first establishment of dentin, via cells known as ameloblasts. (regencydentalgroupblog.com)
Mineralization1
- Enamel mineralization occurs in a strictly synchronized manner along with ameloblast maturation in association with ion transport and pH balance, and any disruption of these processes results in enamel hypomineralization. (jbc.org)
Epithelial cell1
- Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell ameloblast-secreted enamel matrices. (jbc.org)
Secrete enamel1
- Ameloblasts secrete enamel matrix proteins and Ca 2+ , and also regulate extracellular pH as the formation of hydroxyapatite crystals generates large quantities of protons. (frontiersin.org)
Differentiation1
- Ameloblast differentiation and ion transport activities have primarily been investigated by immunohistochemistry and characterization of the enamel phenotypes of knockout mouse models. (frontiersin.org)
Tooth4
- Ameloblasts produce tooth enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth. (medlineplus.gov)
- Recently, eve1 has been shown to be associated with the primary tooth (4V1) and early ameloblast development, the enamel organ precursor (Laurenti et al. (escholarship.org)
- At some point before the tooth erupts into the mouth, but after the maturation stage, the ameloblasts are broken down. (regencydentalgroupblog.com)
- Recent studies have shown alterations during tooth morphogenesis in Jagged2-/- mutant mice, accompanied by defects in ameloblasts cytodifferentiation and poor enamel matrix deposition. (udea.edu.co)
Epithelium1
- Ameloblasts, derived from the oral epithelium, are known to secrete proteins and Ca 2+ into the enamel extracellular matrix. (frontiersin.org)
Vivo2
- CONCLUSIONS: These results indicate that exposure to high levels of fluoride led to endoplasmic reticulum stress which induced apoptosis in cultured ameloblasts and in vivo rat model, suggesting an important role of calcium overload and endoplasmic reticulum stress triggered by high concentrations of fluoride in the development of dental fluorosis. (fluoridealert.org)
- Trafficking and secretion of keratin 75 by ameloblasts in vivo . (bvsalud.org)
MeSH1
- Ameloblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Fluoride1
- RESULT: High fluoride concentration was associated with decreased ameloblast proliferation, elevated ameloblast apoptosis, and increased intracellular Ca2+ in vitro. (fluoridealert.org)
Transitional2
- The next incisal region is a transitional zone in which the ameloblasts separate easily from the enamel. (rupress.org)
- and transitional ameloblasts (Ruffle- to smooth-ended ameloblasts, R-SA). (nii.ac.jp)
Distal3
- Specimens were fixed by perfusion with 0.5% formaldehyde and 0.5% glutaraldehyde followed by decalcification, then freeze-cracked and treated with dilute osmium tetroxide to digest the dense lamina lining the distal surface of the ameloblasts. (nii.ac.jp)
- In these ameloblasts, small granules, presumably connecting the dense lamina to the distal surface of the ameloblasts, were also visible. (nii.ac.jp)
- The distal surface of rat incisor ameloblasts at the early stage of enamel maturation was investigated by high resolution scanning electron microscopy (SEM). (nii.ac.jp)
Rats1
- Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. (rupress.org)
Concentrations1
- A clear lead signal above the background was not detected in the ameloblasts and lead concentrations could only be reliably measured in the developing enamel. (mssm.edu)
Dentin2
- Whole-genome RNA-sequencing analysis of embryonic day (E) 14.5 cap stage molars revealed reductions in early expressed enamel matrix components ( Odontogenic ameloblast-associated protein ) and dentin dysplasia targets ( Dentin matrix acidic phosphoprotein 1 ). (nature.com)
- When this first layer is formed, the ameloblasts move away from the dentin, allowing for the development of Tomes' processes at the apical pole of the cell. (regencydentalgroupblog.com)
Stage1
- In the maturation stage, the ameloblasts transport substances used in the formation of enamel. (regencydentalgroupblog.com)
Teeth1
- The present study describes for the first time the application of synchrotron radiation induced X-ray emission (SRIXE) in measuring the distribution of zinc and lead in the ameloblasts of developing Wistar rat teeth. (mssm.edu)
Dental1
- Las futuras investigaciones abordadas desde la visión translacional ayudarán estética dental, a identificar nuevas mutaciones o nuevos genes, lo cual contribuirá a la evolución en la manera de clasificar, genes. (bvsalud.org)
Formation1
- Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, and also around the end of each Tomes' process, resulting in a deposition of enamel matrix inside of each pit. (regencydentalgroupblog.com)
Odontoblasts11
- Odontoblasts can also be affected, but ameloblasts appear to be more sensitive. (nih.gov)
- 12. GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts. (nih.gov)
- May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. (uniprot.org)
- We have found that MMP-20 transcripts are produced early in development in both the ameloblasts of the enamel organ and the odontoblasts of the pulp organ. (forsyth.org)
- Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. (lookformedical.com)
- Not even one sentence on how teeth were invented, how they evolved, how ameloblasts formed (cells that knit enamel), how odontoblasts formed (cells that knit dentin), how these cells placed themselves in the jaws, how they know exactly how and when to start and stop knitting so that a perfectly sculptured tooth will be the result……and on and on. (evoillusion.org)
- Once the cells that form dentin (odontoblasts) and enamel (ameloblasts) finish forming teeth, they die. (smilesbypayet.com)
- Localization was observed in osteoblasts, ameloblasts and odontoblasts from the developing incisor in day time 1 and 3. (bmn-673.com)
- Odontomas are developmental anomalies due to complete differentiation of epithelial and mesenchymal cells resulting in fully functional ameloblasts and odontoblasts. (kidznteenz.in)
- Dental pulp and enamel biology including cellular, molecular and structural aspects of dentin-pulp complex, cementoblasts, odontoblasts, ameloblasts in both normal and pathological conditions. (nih.gov)
- Primarily pre-ameloblasts which abutted on the dental papilla differentiate the condensed mesenchymal cells into odontoblasts, and secondarily matured odontoblasts which bulged into enamel epithelium produced dentin matrix and differentiated the shrunken pre-ameloblasts into ameloblasts. (jpatholtm.org)
Epithelial2
- The present study was designed to investigate whether a three dimensional (3D) culture of the rat incisor-derived dental epithelial cell line SF2 enhances its differentiation into ameloblast-like cells. (elsevier.com)
- 21. Lourenço SQC, Consolaro A. Apoptosis in odontogenesis: dental lamina, Hertwig's epithelial sheath and reduced ameloblasts. (bvsalud.org)
Analyzing ameloblast differentiation1
- Overall our results suggest that the spheroid culture could be a useful model for analyzing ameloblast differentiation. (elsevier.com)
Amelogenesis1
- In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harbors bovine amelogenin promoter-driven Cre recombinase, and bred this line with TGF-ß receptor II floxed mice to generate ameloblast-specific TGF-ß receptor II conditional knockout (cKO) mice. (harvard.edu)
Maturation2
- We have demonstrated that acid raises fluoride toxicity which the acidity environment from the maturation stage makes ameloblasts even more vunerable to the poisonous ramifications of fluoride publicity [13]. (chk1inhibitors.com)
- Thus, our study indicates that TGF-ß signaling plays an important role in ameloblast functions and enamel maturation. (harvard.edu)
Enamel hypoplasia1
- 17. Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice. (nih.gov)
Tooth enamel2
- Ameloblasts produce tooth enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth. (medlineplus.gov)
- The ectodermal portion forms the enamel organ ( ameloblasts ) that forms the hard tooth enamel layer. (embryology.ch)
Ameloblastin2
- 7. Essential roles of ameloblastin in maintaining ameloblast differentiation and enamel formation. (nih.gov)
- Co-immunoprecipitation assay of mouse ameloblast cell lysates with either ameloblastin or Psma3 antibody identified each reciprocal protein partner. (divbiolchem.org)
Incisor1
- We used microarray technology to compare the expression of miRNAs in three regions of the adult mouse incisor: the laCL, liCL, and ameloblasts. (escholarship.org)
Dental enamel3
- 5. Ameloblasts require active RhoA to generate normal dental enamel. (nih.gov)
- The elaboration of dental enamel by ameloblasts , beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (lookformedical.com)
- 2015-5-26 · Dental enamel is produced by ameloblasts. (actioncams.club)
Cellular2
- Whenever present, ameloblast atrophy should be diagnosed and graded based on the degree of cellular atrophy and the number of ameloblasts affected. (nih.gov)
- At this cellular level, it becomes incorporated into the enamel-forming ameloblasts. (fluoridealert.org)
Secretion2
- 1. The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation. (nih.gov)
- Trafficking and secretion of keratin 75 by ameloblasts in vivo . (bvsalud.org)
Tissue1
- Enamel is a bioceramic tissue composed of thousands of hydroxyapatite crystallites aligned in parallel within boundaries fabricated by a single ameloblast cell. (divbiolchem.org)
Mice1
- In mice, a late-stage ameloblast enhancer has been recognized for the gene (Feng et al. (desfiledelasmilpolleras.com)
Incisors1
- 19. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. (nih.gov)
Mouse1
- Figure Legend: Figure 1 Normal ameloblasts (arrow) in a male B6C3F1 mouse from a chronic study. (nih.gov)
Layer1
- The ameloblast layer is thin (compare with Figure 1), due to the decreased size of the ameloblasts (arrow). (nih.gov)
Study1
- Figure 2 Tooth, Ameloblast - Atrophy in a male F344/N rat from a chronic study. (nih.gov)