Ameloblasts. Medical search

Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)

The elaboration of dental enamel by ameloblasts, beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (Jablonski, Dictionary of Dentistry, 1992).

Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.

The proteins that are part of the dental enamel matrix.

A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)

Any of the eight frontal teeth (four maxillary and four mandibular) having a sharp incisal edge for cutting food and a single root, which occurs in man both as a deciduous and a permanent tooth. (Jablonski, Dictionary of Dentistry, 1992, p820)

A major dental enamel-forming protein found in mammals. In humans the protein is encoded by GENES found on both the X CHROMOSOME and the Y CHROMOSOME.

The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)

The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).

One of a set of bone-like structures in the mouth used for biting and chewing.

The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)

The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)

An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.

A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.

A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.

A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)

Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).

Congenital absence of or defects in structures of the teeth.

The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.

The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)

The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)

The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)

A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)

A source of inorganic fluoride which is used topically to prevent dental caries.

An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.

Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.

The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.

Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.

Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.

Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.

Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.

A wedge-shaped collar of epithelial cells which form the attachment of the gingiva to the tooth surface at the base of the gingival crevice.

Oral tissue surrounding and attached to TEETH.

Neoplasms produced from tooth-forming tissues.

Cysts found in the jaws and arising from epithelium involved in tooth formation. They include follicular cysts (e.g., primordial cyst, dentigerous cyst, multilocular cyst), lateral periodontal cysts, and radicular cysts. They may become keratinized (odontogenic keratocysts). Follicular cysts may give rise to ameloblastomas and, in rare cases, undergo malignant transformation.

The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.

Time period from 1901 through 2000 of the common era.

Societies whose membership is limited to pharmacists.

Activities performed to identify concepts and aspects of published information and research reports.

Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.

Tumors or cancer of the human BREAST.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

A cell line derived from cultured tumor cells.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)

Mesodermal tissue enclosed in the invaginated portion of the epithelial enamel organ and giving rise to the dentin and pulp.

Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)

Dry dissected rat incisor ameloblasts studied in the scanning electron microscope show remarkable specializations of their lateral surfaces. Four or five cycles of a change from a surface with longitudinal gutterlike folds associated with large intercellular spaces, to one with microvilli and reduced intercellular spaces, are found along the length of the lower incisor maturation zone. It is argued that these changes indicate cyclical activity in maturation ameloblasts. (+info)

Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)

Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative ligand. Second, we identified a survival defect in mutant epithelial cells that could be rescued by exogenous laminin 5, collagen, or an antibody against integrin alpha6beta4, suggesting that signaling through beta1 or beta4 integrins is sufficient for survival. Third, we detected abnormalities in ameloblast differentiation in developing mutant incisors indicating that events downstream of adhesion are affected in mutant animals. These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium. (+info)

Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)

About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Northern analysis of RNA from mouse embryos at embryonic days 7, 11, 15, and 17 showed a predominant 4.5 kb band in all stages. By in situ hybridization, Fanca transcripts were found in the whisker follicles, teeth, brain, retina, kidney, liver, and limbs. There was also stage-specific variation in Fanca expression, particularly within the developing whiskers and the brain. Some tissues known to express Fancc (eg, gut) failed to show Fanca expression. These observations show that (1) Fanca is under both tissue- and stage-specific regulation in several tissues; (2) the expression pattern of Fanca is consistent with the phenotype of the human disease; and (3) Fanca expression is not necessarily coupled to that of Fancc. The presence of distinct tissue targets for FA genes suggests that some of the variability in the clinical phenotype can be attributed to the complementation group assignment. (+info)

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)

The continuously growing mouse incisor is an excellent model to analyze the mechanisms for stem cell lineage. We designed an organ culture method for the apical end of the incisor and analyzed the epithelial cell lineage by 5-bromo-2'-deoxyuridine and DiI labeling. Our results indicate that stem cells reside in the cervical loop epithelium consisting of a central core of stellate reticulum cells surrounded by a layer of basal epithelial cells, and that they give rise to transit-amplifying progeny differentiating into enamel forming ameloblasts. We identified slowly dividing cells among the Notch1-expressing stellate reticulum cells in specific locations near the basal epithelial cells expressing lunatic fringe, a secretory molecule modulating Notch signaling. It is known from tissue recombination studies that in the mouse incisor the mesenchyme regulates the continuous growth of epithelium. Expression of Fgf-3 and Fgf-10 were restricted to the mesenchyme underlying the basal epithelial cells and the transit-amplifying cells expressing their receptors Fgfr1b and Fgfr2b. When FGF-10 protein was applied with beads on the cultured cervical loop epithelium it stimulated cell proliferation as well as expression of lunatic fringe. We present a model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression and, thereby, has a central role in coupling the mitogenesis and fate decision of stem cells. (+info)

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)

Dentin sialoprotein and dentin phosphoprotein are non-collagenous proteins that are cleavage products of dentin sialophosphoprotein (DSPP). Although these two protein products are believed to have a crucial role in the process of tooth mineralization, their precise biological functions and the molecular mechanisms of gene regulation are not clearly understood. To understand such functions, we have developed a transgenic mouse model expressing a reporter gene (lacZ) under the control of approximately 6 kb upstream sequences of Dspp. The transgenic fusion protein was designed to reside within the cells to facilitate the precise identification of cell type and developmental stages at which the Dspp-lacZ gene is expressed. The results presented in this report demonstrate: (a) the 6 kb upstream sequences of Dspp have the necessary regulatory elements to direct the tissue specific expression of the transgene similar to endogenous Dspp, (b) both odontoblasts and ameloblasts exhibit transgene expression in a differentiation dependent manner, and (c) a differential regulation of the transgene in odontoblasts and ameloblasts occurs during tooth development and mineralization. (+info)

Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)

The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family, in the developing rat molar tooth was determined by in situ hybridization. At the initiation stage of tooth development, PACE4 mRNA was weakly expressed in the dental lamina, whereas the mesenchymal cells intensely expressed the PACE4 transcript. At the bud stage, high-level expression of PACE4 mRNA was found in the dental epithelium and condensed dental mesenchyme. Its expression became more localized in the differentiating ameloblasts during cap and early bell stages. In the newborn rats, PACE4 mRNA was localized in the ameloblasts and odontoblasts, but its expression became weaker with advancing development, showing apparent association with the differentiation and establishment of functional ameloblasts and odontoblasts. These expression patterns of PACE4 were very similar to those of several bone morphogenetic proteins (BMPs) reported previously. Because BMPs, which are primarily involved in the morphogenesis in tooth formation, are synthesized as inactive precursors and activated by limited proteolysis at the consensus Arg-X-X-Arg maturation site, the present observations suggest that PACE4 is possibly a candidate proBMP convertase that acts during tooth formation. (+info)

Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)

Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histological examinations of individual organs in Sp3(-/-) mice show a pronounced defect in late tooth formation. In Sp3 null mice, the dentin/enamel layer of the developing teeth is impaired due to the lack of ameloblast-specific gene products. Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy. (+info)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)

Previous studies have demonstrated the presence of calbindin D28k in the ameloblasts derived from the inner enamel epithelium. The occlusal surfaces of the rodent molars partly lack the enamel covering, which is referred to as enamel-free area (EFA). In the present study, we compared the immunohistochemical localization of calbindin D28k-like immunoreactivity (CB-LI) in the cells at the EFA (EFA cells) and ameloblasts of the rat molar teeth at the light microscopic level. CB-LI was strong in the ameloblasts of the presecretory through the protective stages, while it was faint at the late secretory to transitional stages. However, some mature ameloblasts lacked the immunoreactivity. On the other hand, the majority of EFA cells showed distinct polarization and elongation that were absent in few cells at the early stage of EFA formation. At all stages, the EFA cells adjacent to the ameloblasts showed CB-LI, however, some cells adjacent to the mature ameloblasts lacked the reaction. Intensive CB-LI was demonstrated in EFA cells at the reduced enamel epithelium. These immunohistochemical findings suggest EFA cells have cytochemical properties similar to those of ameloblasts. (+info)

An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. It most often affects the posterior mandible. It most commonly presents in the third decade of life.[1]. In the WHO/IARC classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst; it was reclassified as keratocystic odontogenic tumour (KCOT) from 2005 to 2017.[2][3] In 2017 it reverted to the earlier name, as the new WHO/IARC classification reclassified OKC back into the cystic category.[4] The WHO/IARC classification no longer considers it a neoplasm, because the evidence supporting that hypothesis (for example, clonality) is considered insufficient. However, this is an area of hot debate within the head and neck pathology community, and some pathologists still regard OKC as a neoplasm despite the reclassification.. ...

https://en.wikipedia.org/wiki/Keratocystic_odontogenic_tumour

Ameloblast • Ameloblastic fibroma • Ameloblastin • Ameloblastoma • Amelogenesis • Amelogenesis imperfecta • Amelogenin • ...

https://en.wikipedia.org/wiki/Index_of_oral_health_and_dental_articles

The ameloblasts cells can be less prominent. Large cysts up to a few centimetres in diameter can be found. In follicular type, ... The most common follicular type has an outer arrangement of columnar or palisaded ameloblasts-like cells and inner zone of ... Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium (ameloblasts, or outside portion, of the teeth ... Resemble a fibro-osseous lesion with no obvious ameloblasts whilst dominated by dense collagenous tissue (desmoplastic). In one ...

https://en.wikipedia.org/wiki/Ameloblastoma

Thus, each band on the enamel rod demonstrates the work/rest pattern of the ameloblasts that generally occurs over a span of a ... Both ameloblasts (the cells which initiate enamel formation) and Tomes' processes affect the crystals' pattern. Enamel crystals ... When this first layer is formed, the ameloblasts move away from the dentin, allowing for the development of Tomes' processes at ... At some point before the tooth erupts into the mouth, but after the maturation stage, the ameloblasts are broken down. ...

https://en.wikipedia.org/wiki/Tooth_enamel

Ameloblasts must also be present for dentinogenesis to continue. A message is sent from the newly differentiated odontoblasts ... It is at this stage that a signal is sent from the newly differentiated ameloblasts back across the dentinoenamel junction (DEJ ... When this first layer is formed, the ameloblasts move away from the interface with dentin, allowing for the development of ... Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, ...

https://en.wikipedia.org/wiki/Amelogenesis

Ameloblasts make enamel at the location of where the cusps of the teeth are located. Enamel grows outwards, away from the ... As the ameloblasts degenerate, a gingival sulcus is created.[citation needed] Frequently, nerves and blood vessels run parallel ... In summary, the layers in order of innermost to outermost consist of dentin, enamel (formed by IEE, or 'ameloblasts', as they ... Outside the dentin are the newly formed ameloblasts in response to the formation of dentin, which are cells that continue the ...

https://en.wikipedia.org/wiki/Human_tooth_development

Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ODAM odontogenic, ameloblast asssociated [sic]". Retrieved 2013-03-31. Moffatt P, Smith CE, Sooknanan R, et al. ( ...

https://en.wikipedia.org/wiki/ODAM_(gene)

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly ... Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast ...

https://en.wikipedia.org/wiki/BCL11B

More than one ameloblast contributes to a single prism. Tomes's processes are distinctly different from Tomes's fibers, which ... During the synthesis of enamel, the ameloblast moves away from the enamel, forming a projection surrounded by the developing ... Tomes's processes (also called Tomes processes) are a histologic landmark identified on an ameloblast, cells involved in the ... Tomes's processes are those projections and give the ameloblast a "picket-fence" appearance under a microscope. They are ...

https://en.wikipedia.org/wiki/Tomes's_process

All tooth enamel, including interrod enamel and enamel rods, is made by ameloblasts. However, interrod enamel is formed ...

https://en.wikipedia.org/wiki/Interrod_enamel

... localizes to the apical secretory pole of mouse ameloblasts". J Biol Chem. 275 (29): 22284-92. doi:10.1074/jbc.M000118200. PMID ...

https://en.wikipedia.org/wiki/TFIP11

The bud-cap stage of normal development shows ameloblasts forming palisades of columnar cells adjacent to a starry-like, ... These proliferate and mature into ameloblasts and fibrous connective tissue (3), and ultimately teeth. Ameloblastic fibromas ...

https://en.wikipedia.org/wiki/Ameloblastic_fibroma

Ameloblast extension rate Duration of ameloblast extension Spreading rate of appositional termination. The appositional growth ... the secretory stage will end and they will transition into maturation stage ameloblasts. These ameloblasts will move down to ... A wave of ameloblasts will then differentiate from the cusp tip and move through the inner enamel epithelia down the slope of ... They are produced by the ameloblast in the bell stage of tooth development. As the crystals are long and closely packed, the ...

https://en.wikipedia.org/wiki/Enamel_organ

These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...

https://en.wikipedia.org/wiki/Human_tooth

2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 ... localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284-92. doi:10.1074/jbc ...

https://en.wikipedia.org/wiki/Tuftelin

The basal cells are an indication of the odontogenic origin as they resemble pre-ameloblasts. The epithelium can separate from ...

https://en.wikipedia.org/wiki/Odontogenic_keratocyst

This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. These ... will differentiate into Ameloblasts which are responsible for secretion of enamel during tooth development. The location of the ...

https://en.wikipedia.org/wiki/Inner_enamel_epithelium

This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not ...

https://en.wikipedia.org/wiki/Ameloblastin

This does not occur in other forms of enamel hypoplasia, such as linear and plane-form, in which all ameloblast activity is ... Each pit is linked to the ceasing of ameloblasts at a particular point in enamel formation. Sometimes, only a couple of ... but all types are associated with a reduction of enamel formation due to disruption in ameloblast production. One of the most ... ameloblasts stop forming enamel, leading to small PEH defects, with large pits forming when hundreds of these enamel-forming ...

https://en.wikipedia.org/wiki/Pitting_enamel_hypoplasia

The ameloblasts also develop hemidesmosomes for the primary EA and become firmly attached to the enamel surface. However, the ... Before the eruption of the tooth and after enamel maturation, the ameloblasts secrete a basal lamina on the tooth surface that ...

https://en.wikipedia.org/wiki/Junctional_epithelium

MMP20 is responsible for the breakdown of extracellular matrix and plays a role in tissue remodeling in ameloblasts. mutations ...

https://en.wikipedia.org/wiki/FAM83H

This is because they are formed by entrapment of odontoblast processes between ameloblasts prior to and during amelogenesis. ...

https://en.wikipedia.org/wiki/Enamel_tufts

More recent evidence has suggested a relationship between respiratory diseases and oxygen shortage of the ameloblasts and MIH. ... due to interruption to the function of ameloblasts. Many factors have been suggested, such as genetics and medical problems ...

https://en.wikipedia.org/wiki/Molar_incisor_hypomineralisation

Ameloblast-like proliferation in the connective tissue and lumen of the cyst may be seen. The standard treatment of calcifying ... Additionally, focal areas of stellate reticulum like cells are seen and near the basement membrane ameloblast-like cells may be ...

https://en.wikipedia.org/wiki/Calcifying_odontogenic_cyst

... or differentiation are mainly due to atypical interaction between odontoblasts and ameloblasts. Histopathologically, deeper ...

https://en.wikipedia.org/wiki/Dentin_dysplasia

Local trauma or abscess formation can adversely affect the ameloblasts overlying a developing crown, resulting in enamel ...

https://en.wikipedia.org/wiki/Enamel_hypocalcification

"Reconstructing impairment of secretory ameloblast function in porcine teeth by analysis of morphological alterations in dental ...

https://en.wikipedia.org/wiki/Linear_enamel_hypoplasia

The key activities of enamelin can be summarised: Necessary for the adhesion of ameloblasts to the surface of the enamel in the ... The formation of enamel's intricate architecture is thought to be rigorously controlled in ameloblasts through interactions of ... growth sites where it is the interface between the ameloblast plasma membrane and lengthening extremity of crystals. ...

https://en.wikipedia.org/wiki/Enamelin

... they may differentiate into fully functional ameloblasts and deposit enamel. Such droplets of enamel are called enamel pearls. ...

https://en.wikipedia.org/wiki/Enamel_pearl

Unlike humans whose ameloblasts die after tooth development, rodents continually produce enamel and must wear down their teeth ...

https://en.wikipedia.org/wiki/Mammal_tooth

Distal terminal bars are junctional complexes that separate the Tomes processes from ameloblast proper. Ameloblasts are ... Initially the preameloblasts will differentiate into presecretory ameloblasts and then into secretory ameloblasts which lay ... ameloblast like cell) cell line is of ameloblastic origin. Ameloblasts are cells which secrete the enamel proteins enamelin and ... Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the ...

https://en.wikipedia.org/wiki/Ameloblast

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis Message Subject (Your Name) has sent you a message ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ...

https://www.pnas.org/content/early/2009/02/25/0900568106.abstract

Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts ( ... Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts ( ... Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the ... Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the ...

https://www.frontiersin.org/articles/10.3389/fphys.2010.00150/full

Micromolar fluoride alters ameloblast lineage cells in vitro.. Author: Yan Q, Zhang Y, Li W, Denbesten PK. ... To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF ( ... The objective of this study was to determine whether epithelial ameloblast-lineage cells, derived from the human enamel organ, ... Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts. OBJECTIVE: The aim of the study was to ...

http://fluoridealert.org/studytracker/18338/

Effects of fluoride on the expression of beclin1 and mTOR in ameloblasts. Author: Lei S, Zhang Y, Zhang K, Li J, Liu L. ... We tested the hypothesis that the sensitivity of forming dental enamel to fluoride (F-) is ameloblast developmental stage- ... In enamel fluorosis model rats treated with sodium fluoride, secretory ameloblasts of incisor tooth germs exhibited disruption ... Short exposure to high levels of fluoride induces stage-dependent structural changes in ameloblasts and enamel mineralization. ...

https://fluoridealert.org/studytracker/23363/

Odontogenic ameloblast-associated proteinAdd BLAST. 264. Amino acid modifications. Feature key. Position(s). DescriptionActions ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ...

https://www.uniprot.org/uniprot/A1E959

Keywords: Ameloblasts, Amelogenesis Imperfecta, Gene expression and Teeth See more of: Genetics and Epigenetics of Craniofacial ... 1561 Expression of FAM20A, causative gene for Amelogenesis Imperfecta in ameloblasts Saturday, March 24, 2012: 9:45 a.m. - 11 a ... The expression was also confirmed in the LS8 ameloblast cell line. The IP-WB analysis was performed using cultured media and ... Conclusion: We demonstrated the intracellular expression of FAM20A in LS8 ameloblasts. Our data suggest that FAM20A is a novel ...

http://www-personal.umich.edu/~sbayne/DMG/DMG-Publications/IADR-AADR-Meeting-Program-Books/2012-AADR-Tampa/2012-AADR-Tampa-CD/AADR12/Paper158375.html

... for the presence of the odontogenic ameloblast-associated protein (ODAM). Within these patient tissues we have observed a ... H. K. Lee, D. S. Lee, H. M. Ryoo, J. T. Park, S. J. Park, H. S. Bae, M. I. Cho and J. C. Park, "The Odontogenic Ameloblast- ... D. P. Kestler, J. S. Foster, S. D. Macy, C. L. Murphy, D. T. Weiss and A. Solomon, "Expression of Odontogenic Ameloblast- ... S. Siddiqui, C. T. Bruker, D. P. Kestler, J. S. Foster, K. D. Gray, A. Solomon and J. L. Bell, "Odontogenic Ameloblast ...

https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=37036

Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium. Authors. *. Clarice Nishio, ... Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ... the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these ... ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, ...

http://onlinelibrary.wiley.com/doi/10.1111/prd.12031/abstract

Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression.. [Juni Sarkar, Emil J Simanian, Sarah Y ... Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The ... In this study we compare the expression profiles of enamel-specific genes in two mouse derived ameloblast-like cell lines: LS8 ...

https://www.sigmaaldrich.com/catalog/papers/25120490

This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ...

http://dev.biologists.org/content/140/16/3348.short

... and the ameloblast (Am) region showing areas of presecretory, secretory and mature ameloblasts (red dashed line). En, enamel; ... For miRNA comparison between the labial CL cells and pre-ameloblast and ameloblast cells, these two regions from the P0 mouse ... Am, ameloblasts; En, enamel; SI, stratum intermedium; SR, stellate reticulum. Scale bars: 1 mm in A-B′; 50 μm in C-J; 20 μm in ... 5A-F), and miR-200c expression was initiated in the labial CL and highly expressed in pre-ameloblasts (Fig. 1B). Pitx2 is ...

https://dev.biologists.org/content/140/16/3348?ijkey=efb3223c2618448917ce8603285f4ad0f15a398a&keytype2=tf_ipsecsha

... - Ameloblasts are cells that deposit enamel, the hard outer most layer that forms the chewing surface.Ameloblasts ... ameloblast. noun Etymology: obsolete amel enamel (Middle English, ultimately from Old French esmail) + -o- + -blast - more at ... ameloblast - ameloblastic, adj. /am euh loh blast /, n. Anat. one of a layer of enamel secreting cells covering the dentin of a ... ameloblast - One of the columnar epithelial cells of the inner layer of the enamel organ of a developing tooth, concerned with ...

http://en.academic.ru/dic.nsf/mwc/1850/ameloblast

... ... resulting in a delay of both odontoblast and ameloblast differentiation. Consequently, enamel volume and thickness are ...

http://publica.fraunhofer.de/dokumente/N-301622.html

The morphology of SOCE-deficient ameloblasts was altered, showing loss of the typical ruffled border, resulting in mislocalized ... Global gene expression analysis of SOCE-deficient ameloblasts revealed strong dysregulation of several pathways. ER stress ... Store-operated Ca2+ entry controls ameloblast cell function and enamel development. ... Store-operated Ca2+ entry controls ameloblast cell function and enamel development. ...

https://insight.jci.org/articles/view/91166/pdf

Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ...

http://cancerres.aacrjournals.org/content/72/8_Supplement/92

... which supports the theory that ameloblasts and odontoblasts are target-cells for 1,25 is presented. As a perspective, a cross- ... Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review.. A Berdal, P Papagerakis, D Hotton, I ... which supports the theory that ameloblasts and odontoblasts are target-cells for 1,25 is presented. As a perspective, a cross- ...

http://www.ijdb.ehu.es/web/paper/7626415/ameloblasts-and-odontoblasts-target-cells-for-125-dihydroxyvitamin-d3-a-review

Journal Article] Characteristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts. *. Author(s ... Journal Article] Characteristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts2005. *. ... Journal Article] Characterristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts2005. *. ... Immunoreation became weak in the ameloblasts towards cervical regions. Furthermore, Shh-immunoreation was distributed in the ...

https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591927/

A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination ZORA ... Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with ... Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with ... Download PDF A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage ...

https://www.zora.uzh.ch/id/eprint/9217/

Presentation] Exploring the roles of core-binding factor β (CBFB) in tooth development and ameloblast physiology.2010. *. ... Presentation] Exploring the roles of core-binding factor β (CBFB) in tooth development and ameloblast physiology.2010. *. ... Presentation] Exploring the roles of core-binding factor β (CBFB) in tooth development and_ameloblast physiology2010. *. Author ... Presentation] Exploring the roles of core-binding factor β (CBFB) in tooth development and ameloblast physiology2010. *. Author ...

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792072/

This distinction was based primarily upon the configuration of the distal ends of the ameloblasts and the presence or absence ... compare calcium levels in various regions of tissue identified as constituting either ruffle-ended or smooth ended ameloblasts ... Scanning electron microscopy was used to distinguish the topographical characteristics of two maturation ameloblast types in ... This distinction was based primarily upon the configuration of the distal ends of the ameloblasts and the presence or absence ...

https://digitalcommons.usu.edu/microscopy/vol3/iss2/26/

p27 was expressed in P7 Ambn+/− ameloblasts but not P7 Ambn−/− ameloblasts, but p75 was expressed in P7 Ambn−/− ameloblasts but ... p27 was expressed in P7 Ambn+/− ameloblasts but not P7 Ambn−/− ameloblasts, but p75 was expressed in P7 Ambn−/− ameloblasts but ... ameloblasts Because Ambn−/− ameloblasts proliferate and accumulate in a multicell layer at the secretory stage, we hypothesized ... p27, a Cdk inhibitor, was strongly expressed in P7 ameloblasts compared with P3 ameloblasts in Ambn+/− tooth (Bloch-Zupan et al ...

https://rupress.org/jcb/article/167/5/973/34145/Ameloblastin-is-a-cell-adhesion-molecule-required

The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel ... The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel ... To investigate the role of β-catenin in ameloblasts, we established Amelx-Cre; β-catenin∆ex3fl/fl (CA-β-catenin) mice, which ... To investigate the role of β-catenin in ameloblasts, we established Amelx-Cre; β-catenin∆ex3fl/fl (CA-β-catenin) mice, which ...

https://hub.hku.hk/handle/10722/279122

... differentiate into early ameloblasts during the bell stage. Early ameloblasts differentiate into mature cells through pre- ... During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. In ...

https://discovery.lifemapsc.com/in-vivo-development/tooth/dental-enamel/early-ameloblasts

Evidence for Bicarbonate Secretion by Ameloblasts in a Novel Cellular Model. E. Bori, J. Guo, R. Rácz, B. Burghardt, A. Földes ... Fingerprint Dive into the research topics of Evidence for Bicarbonate Secretion by Ameloblasts in a Novel Cellular Model. ...

https://hungary.pure.elsevier.com/en/publications/evidence-for-bicarbonate-secretion-by-ameloblasts-in-a-novel-cell/fingerprints/

... odontogenic ameloblast-associated (ODAM) and amelotin (AMTN), have been identified in the JE. The objective of this study was ... Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional ... Localization and expression pattern of amelotin, odontogenic ameloblast-associated protein and follicular dendritic cell- ... article{Nishio2010ExpressionPO, title={Expression pattern of odontogenic ameloblast-associated and amelotin during formation ...

https://www.semanticscholar.org/paper/Expression-pattern-of-odontogenic-ameloblast-assoc-Nishio-Wazen/9c7ba667ee6388036971fafcd4eb5510c111c099

Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and ... and well-differentiated ameloblasts (am) at day 9 (E), respectively, after subrenal culture. F hKSC-derived ameloblasts began ... Induction of human keratinocytes into enamel-secreting ameloblasts. Dev Biol. 2010;344:795.View ArticlePubMedPubMed Central ... Bei M, Stowell S, Maas R. Msx2 controls ameloblast terminal differentiation. Dev Dyn. 2004;231(4):758-65.View ArticlePubMed ...

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0822-4

The life cycle of ameloblasts consists of six stages: Morphogenic stage; Organizing stage; Formative (secretory) stage (Tomes ... Disruption of the ameloblast Documents. From Wikipedia, the free encyclopedia. ,ife. Life Cycle of Ameloblast. Write in tabular ... In the ameloblast life cycle, Ameloblasts are cells present only during tooth development that deposit tooth enamelwhich is the ... LIFE CYCLE OF AMELOBLAST. Distal terminal bars are junctional complexes that separate the Tomes processes from ameloblast ...

https://meerschaum-pipes.eu/life-cycle-of-ameloblast-45/

Ameloblasts deposited a basal lamina on immature enamel. Conversely, in serumless conditions, ameloblasts formed enamel on ... Moreover, maturation-stage ameloblasts did not form basal lamina and directly absorbed mineralized enamel after 28 days of ... In serum-supplemented conditions, inner enamel epithelial cells differentiated into secretory-stage ameloblasts, which formed ... In the absence of a basal lamina, ameloblasts absorb enamel in a serumless and chemically defined organ culture system. ...

https://pesquisa.bvsalud.org/portal/resource/pt/mdl-33493674

Remarkably, Satb1−/− ameloblasts at the secretory stage lost many morphological characteristics found at the apical surface of ... Our data show that SATB1 is essential for establishing secretory ameloblast cell polarity and for EMP secretion. In line with ... Oral epithelial cell-derived ameloblasts at secretory stage (SABs) synthesize large amounts of enamel matrix proteins (EMPs), ... The Satb1−/− mice possessed deformed ameloblasts and a thin layer of hypomineralized and non-prismatic enamel. ...

https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0722-9/figures/3

ameloblast - One of the columnar epithelial cells of the inner layer of the enamel organ of a developing tooth, concerned with the formation of enamel matrix. (academic.ru)
Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with proliferative events. (uzh.ch)
The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel formation and mineralization. (hku.hk)
In serum -supplemented conditions, inner enamel epithelial cells differentiated into secretory-stage ameloblasts , which formed enamel and reached the maturation stage after 14 and 21 days of culture , respectively. (bvsalud.org)
The researchers found that follistatin was expressed at low levels in active ameloblasts and at much higher levels in the dental epithelial cells lining the enamel-free surface of the incisors. (eurekalert.org)
Mineralized tissues include enamel (produced by the epithelial cells called ameloblasts), dentin an. (bioportfolio.com)
Our results indicate that stem cells reside in the cervical loop epithelium consisting of a central core of stellate reticulum cells surrounded by a layer of basal epithelial cells, and that they give rise to transit-amplifying progeny differentiating into enamel forming ameloblasts. (nih.gov)

Ameloblasts are derived from oral epithelium tissue of ectodermal origin. (wikipedia.org)
When Follistatin, a BMP inhibitor, is over expressed in the epithelium of developing teeth, the ameloblasts do not differentiate and no enamel forms. (wikipedia.org)
Another example includes the conditional deletion of 'Dicer-1' in the epithelium of developing teeth may cause impaired differentiation of ameloblasts which results in deficient enamel formation. (wikipedia.org)
Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ameloblasts and in the junctional epithelium. (wiley.com)
This article reviews the structure and function of the junctional epithelium, the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these proteins in the formation and regeneration of the junctional epithelium. (wiley.com)
Cells of the inner enamel epithelium located adjacent to the dental papilla mesenchymal cells, differentiate into early ameloblasts during the bell stage. (lifemapsc.com)
Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional epithelium. (semanticscholar.org)
Cytodifferentiation of dental epithelia to enamel-producing ameloblasts or root epithelium cell lineage compartmentalizes teeth into crowns and roots. (umich.edu)
it was not expressed in the oral epithelium that gives rise to ameloblasts. (eurekalert.org)
This indicated that a disrupted cross-signaling between mesenchyme and epithelium was the reason for the failed maturation of ameloblasts. (eurekalert.org)
This epithelium comprises a single layer of columnar cells called ameloblasts. (sciencephoto.com)
While it is well established that cells called ameloblasts secrete enamel, the molecular signals regulating asymmetric ameloblast differentiation from the underlying dental epithelium are not well understood. (eurekalert.org)

We have examined primary tumor sections from melanoma patients by immunohistochmistry (IHC) for the presence of the odontogenic ameloblast-associated protein (ODAM). (scirp.org)
Recently, it has been shown by immunohistochemical staining of tumor biopsy tissue that nuclear localization of the odontogenic ameloblast associated protein (ODAM) correlated with staging and increased survival in patients, leading to the proposal of this protein as a novel biomarker in breast cancer. (aacrjournals.org)
The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. (biomedcentral.com)
To elucidate the function of the odontogenic ameloblast-associated protein (ODAM) in ameloblasts, we identified more than 74 proteins that interact with ODAM using protoarray. (yonsei.ac.kr)
ODAM and BMPR-IB exhibited similar patterns of expression in vitro, during ameloblast differentiation. (yonsei.ac.kr)
ODAM phosphorylation was detected in ameloblasts during ameloblast differentiation and enamel mineralization in vitro and involved in the activation of downstream factors of MAPKs. (yonsei.ac.kr)
Therefore, the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization. (yonsei.ac.kr)
The gene for odontogenic ameloblast-associated ( ODAM ) is a member of the secretory calcium-binding phosphoprotein gene family. (biomedcentral.com)
Early in tooth development, ODAM is highly expressed in the enamel organ that gives rise to ameloblasts that produce enamel. (biomedcentral.com)

The differentiation from preameloblasts to ameloblasts occurs during the first stage of amelogenesis, called the pre-secretory (or inductive) phase. (wikipedia.org)
Little was known about the regulatory mechanism of Wnt/β-catenin signaling pathway in ameloblasts during amelogenesis, especially in the mineralization of enamel. (hku.hk)
These data indicated that β-catenin plays an essential role in differentiation and function of ameloblasts during amelogenesis. (hku.hk)
Background: Ameloblast differentiation is the most critical stepwise process in amelogenesis and controlled by a precisely molecules synergistically. (omicsdi.org)
To better understand the molecular events defining cell differentiation between preameloblasts and secretory ameloblasts during amelogenesis, a more precise identification of molecules and signaling networks would shed light on the mechanisms governing enamel formation and help lay a foundation for enamel regeneration. (omicsdi.org)
Enamel formation occurs through the process of amelogenesis, during which ameloblast cells form and secrete the extracellular matrix which eventually matures into the outer hydroxyapatite layer of the tooth. (nih.gov)
Interestingly, Dmp1 expression became evident in ameloblasts during the maturative phase of amelogenesis. (unboundmedicine.com)
NCKX4 is highly expressed and regulates Ca 2+ transport in ameloblasts during amelogenesis (the formation of tooth enamel). (tcdb.org)
Amelogenin and ameloblastin have an impaired secretion in ameloblasts of phenocopies human X-linked amelogenesis imperfect mice, which results in severe enamel bio-mineralization defects, loss of ameloblast phenotype, increased ameloblast apoptosis, and formation of multi-cellular masses (Barron et al. (atlasgeneticsoncology.org)

This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of microRNAs in this process. (biologists.org)

The ameloblasts will only become fully functional after the first layer of dentin (predentin) has been formed by odontoblasts. (wikipedia.org)
Conversely, in serumless conditions, ameloblasts formed enamel on mineralized dentin after 21 days. (bvsalud.org)
These results indicate that several differences were detected compared to the development in serum -supplemented conditions, such as delayed enamel and dentin formation and the failure of maturation-stage ameloblasts to form basal laminae. (bvsalud.org)
Wild-type secretory ameloblasts (SAB) ( f ), enamel ( e ), and dentin ( d ) are illustrated in the enlarged image. (biomedcentral.com)
Coincident with this process, adjacent epithelial and mesenchymal cells differentiate into enamel-secreting ameloblasts and dentin-secreting odontoblasts, respectively. (nih.gov)
AMTN is no longer detected in the ameloblasts around the crown, but is identified in the cells at the surface of the dentin shaft, in a region lacking enamel. (biomedcentral.com)
A number of cell types, including the ameloblasts and odontoblasts that secrete the mineralized enamel and dentin, respectively, are constantly generated by progenitors located at the proximal end of the tooth ( Figure 1A,B ). These cells replenish the tissues that are lost from the distal end of the tooth due to abrasion during gnawing. (elifesciences.org)

Insufficient basement membrane degradation is evidenced by a persistent laminin immunostaining, resulting in a delay of both odontoblast and ameloblast differentiation. (fraunhofer.de)
Exploring the way to make a correct induction from stem cells to odontoblast and ameloblasts. (nii.ac.jp)
In total, 4 odontoblast, 4 pre-secretory ameloblast and 4 secretory ameloblast pooled samples were used for RNA extraction and microarray analysis. (omicsdi.org)
At birth, the size and the shape of the teeth are severely affected and the polarity and organization of the ameloblast and odontoblast layers is disrupted. (nih.gov)
Without Sp7, the animals had small, misshapen teeth, and the odontoblasts and ameloblasts failed to mature beyond the pre-odontoblast and pre-ameloblast stage, as measured by absence of mature cell markers for those two types of cells. (eurekalert.org)

Ameloblasts are cells which secrete the enamel proteins enamelin and amelogenin which will later mineralize to form enamel, the hardest substance in the human body. (wikipedia.org)
During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. (lifemapsc.com)
Bcl9, Bcl9l, and Pygo2 were present in the cytoplasm of ameloblasts, the cells that secrete enamel proteins, and colocalized in these cells with amelogenin, the main component of enamel. (sciencemag.org)
In ameloblasts, Bcl9 interacted with proteins involved in enamel formation and proteins involved in exocytosis and vesicular trafficking. (sciencemag.org)
Of the identified proteins, bone morphogenetic protein receptor type-IB (BMPR-IB) was physiologically relevant in differentiating ameloblasts. (yonsei.ac.kr)

Perturbations of gene expression were also observed in the mandible of Ctip2 −/− mice: expression of the ameloblast markers amelogenin , ameloblastin , and enamelin was down-regulated, as was expression of Msx2 and epiprofin , transcription factors implicated in the tooth development and ameloblast differentiation. (pnas.org)

Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses odontogenic potential, the induction rate is relatively low. (biomedcentral.com)

To characterize the biological function of FAM20A, as a preliminary step, the present study is sought to investigate the expression and localization of endogenous Fam20a in an ameloblast cell line, LS8. (umich.edu)
The expression was also confirmed in the LS8 ameloblast cell line. (umich.edu)
Conclusion: We demonstrated the intracellular expression of FAM20A in LS8 ameloblasts. (umich.edu)
Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. (sigmaaldrich.com)
In this study we compare the expression profiles of enamel-specific genes in two mouse derived ameloblast-like cell lines: LS8 and ALC cells. (sigmaaldrich.com)
Global gene expression analysis of SOCE-deficient ameloblasts revealed strong dysregulation of several pathways. (jci.org)
Furthermore, in situ hybridization histochemistry and immunocytochemistry confirmed the region-specific expression of Alpha-and Gamma-ENac in the ameloblasts layer. (nii.ac.jp)
These results indicate that Tbx1 expression in developing teeth is under control of FGF signaling and correlates with determination of the ameloblast lineage. (uzh.ch)
Results: Gene expression profiles of human preameloblast and secretory ameloblast cells were obtained using human genome microarrays. (omicsdi.org)
Two co-expression modules were further identified significantly associated with the ameloblast differentiation process by weighted gene co-expression network analysis (WGCNA).These gene networks seem to contribute to cell adhesion, tissue development, cell signaling and division. (omicsdi.org)
Specifically, expression of genes associated with cell cycle control, DNA damage repair, and apoptosis pathways regulates pre-ameloblast maturation during tooth development. (omicsdi.org)
A strong AMTN expression is observed in the ameloblasts both facing the mineralized enamel and the recently deposited enamel matrix along the tooth shaft. (biomedcentral.com)
Decreased expression and increased phosphorylation of Forkhead box o1 (Foxo1) in ameloblasts were observed both in vivo and in vitro when treated by fluoride. (springer.com)
Le MH, Nakano Y, Abduweli Uyghurturk D, Zhu L, Den Besten PK (2017) Fluoride alters Klk4 expression in maturation ameloblasts through androgen and progesterone receptor signaling. (springer.com)
Zhang Y, Yan Q, Li W, DenBesten PK (2006) Fluoride down-regulates the expression of matrix metalloproteinase-20 in human fetal tooth ameloblast-lineage cells in vitro. (springer.com)
In early secretory ameloblasts, DSPP expression was transient and down-regulated with the appearance ofdentin matrix. (unboundmedicine.com)
In this study, we investigated the regulation of MMP-20 and possible effects of fluoride on MMP-20 expression in human ameloblast lineage cells. (biomedsearch.com)
While the mechanism that dampens follistatin expression in unknown, it is clear that the lack of follistatin allows BMP signals to stimulate ameloblast differentiation on the labial side of the incisor. (eurekalert.org)

It is theorized that a circadian clock (24-hour) probably regulates enamel production on a daily cycle by the ameloblasts (similar to osteoblasts in production of bone tissue). (wikipedia.org)
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. (ucsf.edu)

The life cycle of ameloblasts consists of six stages: Morphogenic stage Organizing stage Formative (secretory) stage (Tomes' processes appear) Maturative stages Protective stage Desmolytic stage The murine ALC (ameloblast like cell) cell line is of ameloblastic origin. (wikipedia.org)
Life Cycle of Ameloblasts. (meerschaum-pipes.eu)
The life cycle of ameloblasts [3]: Life Cycle of Ameloblast Download Report. (meerschaum-pipes.eu)

Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts (SA) and RAs stained positive with anti-claudin-1 antibodies. (frontiersin.org)
These two types of ameloblasts are referred to as ruffle-ended ameloblasts (RA) and smooth-ended ameloblasts (SA), respectively. (frontiersin.org)
Energy dispersive x-ray spectrometry was applied to compare calcium levels in various regions of tissue identified as constituting either ruffle-ended or smooth ended ameloblasts. (usu.edu)

Moreover, maturation-stage ameloblasts did not form basal lamina and directly absorbed mineralized enamel after 28 days of culture . (bvsalud.org)
Exposure of enamel surfaces underlying maturation-stage ameloblasts to pH indicator dyes suggested the presence of diffusion barriers in fluorotic enamel. (nih.gov)

Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell lineage. (pnas.org)

The secretory end of the ameloblast ends in a six-sided pyramid-like projection known as the Tomes' process. (wikipedia.org)
Distal terminal bars are junctional complexes that separate the Tomes' processes from ameloblast proper. (wikipedia.org)
Both ameloblasts (the cells which initiate enamel formation) and Tomes' processes affect the crystals' pattern. (bionity.com)
Tomes processes of secretory ameloblasts (Krebsbach et al. (atlasgeneticsoncology.org)

These sections were used for laser capture microdissection (LCM) to isolate the human odontoblasts and ameloblasts in different stages of enamel formation, using static image settings. (omicsdi.org)
This was due to reduced proliferation, maturation and polarization of the tooth-forming cells called odontoblasts and ameloblasts. (eurekalert.org)
The odontoblasts and ameloblasts were fewer in number and showed disorganized alignments. (eurekalert.org)

An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. (pnas.org)
These findings will aid in the design of new strategies to promote ameloblast functional differentiation in the regeneration and tissue engineering of teeth. (omicsdi.org)

Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. (sigmaaldrich.com)
We tested this concept by analyzing fluorotic enamel defects in wild-type mice and mice deficient in anion exchanger-2a,b (Ae2a,b), a transmembrane protein in maturation ameloblasts that exchanges extracellular Cl(-) for bicarbonate. (nih.gov)
1997). Interactions between the ameloblasts and the enamel extracellular matrix (Fukumoto et al. (atlasgeneticsoncology.org)

Initially the preameloblasts will differentiate into presecretory ameloblasts and then into secretory ameloblasts which lay down the tooth enamel. (wikipedia.org)
Early ameloblasts differentiate into mature cells through pre-secretory and secretory stages. (lifemapsc.com)

ameloblast - ameloblastic, adj. (academic.ru)
The murine ALC ameloblast like cell cell line is of ameloblastic origin. (meerschaum-pipes.eu)

Micromolar fluoride alters ameloblast lineage cells in vitro. (fluoridealert.org)
The objective of this study was to determine whether epithelial ameloblast-lineage cells, derived from the human enamel organ, are directly affected by micromolar concentrations of fluoride. (fluoridealert.org)
Fluoride had a biphasic effect on cell proliferation, with enhanced proliferation at 16 microM, and reduced proliferation at greater than 1 mM F. Flow cytometry showed that both 10 microM and 20 microM NaF significantly increased the apoptotic index of ameloblast-lineage cells. (fluoridealert.org)
These results indicate multiple effects of micromolar fluoride on ameloblast-lineage cells. (fluoridealert.org)

2009). The absence of ameloblastin in epithelial odontogenic tumors has been considered a useful marker for the functional differentiation of secretory ameloblast (Takata et al. (atlasgeneticsoncology.org)

Bmpr1a knockout during cytodifferentiation stage switched the direction of dental epithelial differentiation from ameloblasts to cementoblasts at both molar crowns and labial side of incisors, which was mediated by promotion of epithelial-mesenchymal transition (EMT) via upregulation of EMT associated transcription factors and downregulation of miR-200 family. (umich.edu)

Thesleff I, Aberg T. Tooth morphogenesis and differentiation of ameloblasts. (uptodate.com)
Altogether, the UAB researchers concluded that Sp7 is obligatory for differentiation of ameloblasts and odontoblasts, but not for the initial tooth morphogenesis. (eurekalert.org)

Life cycle of ameloblastLife cycle of ameloblasts Morphogenic stage: Organising stage: Formative stage: Maturative stage: Protective stage. (meerschaum-pipes.eu)
The cervical loop area: Life cycle of ameloblastLife cycle of ameloblasts Morphogenic stage: Life cycle of ameloblast. (meerschaum-pipes.eu)

Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the presence of claudin-1 in the Golgi cisterns may indicate the presence of tight junction precursors before transportation to the junctional area. (frontiersin.org)

Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the tooth forming the surface of the crown. (wikipedia.org)
Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review. (ehu.es)
Finally, the data obtained with calbindin-D9k, calbindin-D28k, osteocalcin and VDR, which supports the theory that ameloblasts and odontoblasts are target-cells for 1,25 is presented. (ehu.es)
Bcl9, Bcl9l, and Pygo2 localized mainly to the cytoplasm of the epithelial-derived ameloblasts, the cells responsible for enamel production. (sciencemag.org)
These efforts may include establishing cells in the ameloblast lineage that retain their properties in culture or 3-dimensional co-cultures of various cell types that incorporate multiple biological signals necessary for the differentiation, growth, and function of ameloblast cells. (nih.gov)
The ameloblasts are no longer labelled at the top of the tooth, where enamel is mature (empty space after demineralization), but are labelled in the cells facing the tooth matrix along the tooth shaft. (biomedcentral.com)
The protein is found in several types of cells, including specialized cells called ameloblasts. (medlineplus.gov)
Ameloblast-like cells (LS8 cells) were exposed to NaF at selected concentration (0/2 mM) for 24 h. (springer.com)
Wahluyo S, Ismiyatin K, Purwanto B, Mukono IS (2017) The influence of sodium fluoride on the growth of ameloblasts and kidney proximal tubular cells. (springer.com)
In contrast, fully differentiated cells, such as ameloblasts. (docme.ru)

In the absence of a basal lamina, ameloblasts absorb enamel in a serumless and chemically defined organ culture system. (bvsalud.org)
Ameloblasts deposited a basal lamina on immature enamel . (bvsalud.org)

Consistent with increased oxidative stress, we found increased ROS production, decreased mitochondrial function, and abnormal mitochondrial morphology in ameloblasts of Stim1/2 K14cre mice. (jci.org)
β-catenin∆ex3fl/fl (CA-β-catenin) mice, which could constitutive activate β-catenin in ameloblasts. (hku.hk)
Mice engineered to lack follistatin had functional ameloblasts on the normally enamel-free surface adjacent to the tongue. (eurekalert.org)

Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross section. (wikipedia.org)
Maturation ameloblasts undergo several modulation cycles, involving two different types of cell morphology, during enamel maturation ( Josephsen and Fejerskov, 1977 ). (frontiersin.org)
Bcl9 and Pygo2 are present in differentiated, secretory ameloblasts but not in the stem cell niche. (sciencemag.org)

The polarity of ameloblasts and odontoblasts is crucial for their differentiation and function. (bvsalud.org)
This review summarizes the process of polarity formation of ameloblasts and odontoblasts and their related regulators. (bvsalud.org)

Multiple mechanisms, including direct fluoride-related effects on ameloblasts (secretory and maturation phases), indirect fluoride-related effects on the forming matrix (nucleation and crystal growth in all stages of enamel formation), and calcium homeostasis, can result in dental fluorosis depending on the dose and duration of fluoride exposure [ 4 , 5 ]. (mdpi.com)

The goal of the study was to characterize the whole genome transcriptome profiles of human ameloblasts and odontoblasts, evaluate molecular pathways and advance our knowledge of the human tooth development. (omicsdi.org)
Conclusions: In this study, we uncovered that the differentiation from PAB to SAB may rely on a highly regulated network of interactions between conserved signal transduction pathways, including members of BMP/TGF-β, Notch, MAPK pathways to coordinate all aspects of ameloblast in intracellular processes and their social contexts. (omicsdi.org)

Further investigation revealed that follistatin prevents enamel formation by inhibiting BMP signaling molecules that are potent stimulators of ameloblast differentiation. (eurekalert.org)

The ameloblasts surrounding the enameloid cap express AMTN . (biomedcentral.com)

Anatomy17

Diseases9

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Analytical, Diagnostic and Therapeutic Techniques and Equipment1

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Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)

Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)

Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)

Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)

Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)

Ameloblasts

Amelogenesis

Enamel Organ

Dental Enamel Proteins

Dental Enamel

Incisor

Amelogenin

Tooth Calcification

Odontogenesis

Tooth

Tooth Germ

Odontoblasts

Molar

Dental Enamel Hypoplasia

Amelogenesis Imperfecta

Matrix Metalloproteinase 20

Fluorosis, Dental

SLC4A Proteins

Tooth Abnormalities

Plastic Embedding

Dentin

Dentinogenesis

Tooth Crown

Dental Pulp

Sodium Fluoride

Claudin-1

Fluorides

Mandible

Anion Transport Proteins

Proton Pumps

Antiporters

Sodium-Bicarbonate Symporters

Epithelial Attachment

Gingiva

Odontogenic Tumors

Odontogenic Cysts

Bacteriology

History, 20th Century

Societies, Pharmaceutical

Abstracting and Indexing as Topic

Data Mining

Breast Neoplasms

Extracellular Matrix

Cell Line, Tumor

Neoplasm Invasiveness

Hypophosphatasia

Dental Papilla

Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)

Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)

Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)

Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)

Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)

HKU Scholars Hub: Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS

Early Ameloblasts Development in the Dental Enamel - LifeMap Discovery

Quintessence Publishing

Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-Aldrich

Scientists uncover secret to sharp teeth | EurekAlert! Science News

New connections: Protein trafficking for strong bones and teeth | Science Signaling

Alan Brymer on How To Run a Successful Real Estate Business Monday, August 4, 2008

Incisor - wikidoc

Gene expression in tooth: references

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Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium - Nishio - 2013 -...

Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFβ1 in mouse gingival...

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