Ameloblasts: Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)Amelogenesis: The elaboration of dental enamel by ameloblasts, beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (Jablonski, Dictionary of Dentistry, 1992).Enamel Organ: Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.Dental Enamel Proteins: The proteins that are part of the dental enamel matrix.Dental Enamel: A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)Incisor: Any of the eight frontal teeth (four maxillary and four mandibular) having a sharp incisal edge for cutting food and a single root, which occurs in man both as a deciduous and a permanent tooth. (Jablonski, Dictionary of Dentistry, 1992, p820)Amelogenin: A major dental enamel-forming protein found in mammals. In humans the protein is encoded by GENES found on both the X CHROMOSOME and the Y CHROMOSOME.Tooth Calcification: The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)Odontogenesis: The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).Tooth: One of a set of bone-like structures in the mouth used for biting and chewing.Tooth Germ: The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)OdontoblastsMolar: The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)Dental Enamel Hypoplasia: An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.Amelogenesis Imperfecta: A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.Matrix Metalloproteinase 20: A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.Fluorosis, Dental: A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)SLC4A Proteins: Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).Tooth Abnormalities: Congenital absence of or defects in structures of the teeth.Plastic Embedding: The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.Dentin: The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)Dentinogenesis: The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)Tooth Crown: The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)Dental Pulp: A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)Sodium Fluoride: A source of inorganic fluoride which is used topically to prevent dental caries.Claudin-1: An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.Fluorides: Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Anion Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.Proton Pumps: Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.Antiporters: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Sodium-Bicarbonate Symporters: Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.

Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)

Dry dissected rat incisor ameloblasts studied in the scanning electron microscope show remarkable specializations of their lateral surfaces. Four or five cycles of a change from a surface with longitudinal gutterlike folds associated with large intercellular spaces, to one with microvilli and reduced intercellular spaces, are found along the length of the lower incisor maturation zone. It is argued that these changes indicate cyclical activity in maturation ameloblasts.  (+info)

Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)

Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative ligand. Second, we identified a survival defect in mutant epithelial cells that could be rescued by exogenous laminin 5, collagen, or an antibody against integrin alpha6beta4, suggesting that signaling through beta1 or beta4 integrins is sufficient for survival. Third, we detected abnormalities in ameloblast differentiation in developing mutant incisors indicating that events downstream of adhesion are affected in mutant animals. These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium.  (+info)

Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)

About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Northern analysis of RNA from mouse embryos at embryonic days 7, 11, 15, and 17 showed a predominant 4.5 kb band in all stages. By in situ hybridization, Fanca transcripts were found in the whisker follicles, teeth, brain, retina, kidney, liver, and limbs. There was also stage-specific variation in Fanca expression, particularly within the developing whiskers and the brain. Some tissues known to express Fancc (eg, gut) failed to show Fanca expression. These observations show that (1) Fanca is under both tissue- and stage-specific regulation in several tissues; (2) the expression pattern of Fanca is consistent with the phenotype of the human disease; and (3) Fanca expression is not necessarily coupled to that of Fancc. The presence of distinct tissue targets for FA genes suggests that some of the variability in the clinical phenotype can be attributed to the complementation group assignment.  (+info)

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)

The continuously growing mouse incisor is an excellent model to analyze the mechanisms for stem cell lineage. We designed an organ culture method for the apical end of the incisor and analyzed the epithelial cell lineage by 5-bromo-2'-deoxyuridine and DiI labeling. Our results indicate that stem cells reside in the cervical loop epithelium consisting of a central core of stellate reticulum cells surrounded by a layer of basal epithelial cells, and that they give rise to transit-amplifying progeny differentiating into enamel forming ameloblasts. We identified slowly dividing cells among the Notch1-expressing stellate reticulum cells in specific locations near the basal epithelial cells expressing lunatic fringe, a secretory molecule modulating Notch signaling. It is known from tissue recombination studies that in the mouse incisor the mesenchyme regulates the continuous growth of epithelium. Expression of Fgf-3 and Fgf-10 were restricted to the mesenchyme underlying the basal epithelial cells and the transit-amplifying cells expressing their receptors Fgfr1b and Fgfr2b. When FGF-10 protein was applied with beads on the cultured cervical loop epithelium it stimulated cell proliferation as well as expression of lunatic fringe. We present a model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression and, thereby, has a central role in coupling the mitogenesis and fate decision of stem cells.  (+info)

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)

Dentin sialoprotein and dentin phosphoprotein are non-collagenous proteins that are cleavage products of dentin sialophosphoprotein (DSPP). Although these two protein products are believed to have a crucial role in the process of tooth mineralization, their precise biological functions and the molecular mechanisms of gene regulation are not clearly understood. To understand such functions, we have developed a transgenic mouse model expressing a reporter gene (lacZ) under the control of approximately 6 kb upstream sequences of Dspp. The transgenic fusion protein was designed to reside within the cells to facilitate the precise identification of cell type and developmental stages at which the Dspp-lacZ gene is expressed. The results presented in this report demonstrate: (a) the 6 kb upstream sequences of Dspp have the necessary regulatory elements to direct the tissue specific expression of the transgene similar to endogenous Dspp, (b) both odontoblasts and ameloblasts exhibit transgene expression in a differentiation dependent manner, and (c) a differential regulation of the transgene in odontoblasts and ameloblasts occurs during tooth development and mineralization.  (+info)

Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)

The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family, in the developing rat molar tooth was determined by in situ hybridization. At the initiation stage of tooth development, PACE4 mRNA was weakly expressed in the dental lamina, whereas the mesenchymal cells intensely expressed the PACE4 transcript. At the bud stage, high-level expression of PACE4 mRNA was found in the dental epithelium and condensed dental mesenchyme. Its expression became more localized in the differentiating ameloblasts during cap and early bell stages. In the newborn rats, PACE4 mRNA was localized in the ameloblasts and odontoblasts, but its expression became weaker with advancing development, showing apparent association with the differentiation and establishment of functional ameloblasts and odontoblasts. These expression patterns of PACE4 were very similar to those of several bone morphogenetic proteins (BMPs) reported previously. Because BMPs, which are primarily involved in the morphogenesis in tooth formation, are synthesized as inactive precursors and activated by limited proteolysis at the consensus Arg-X-X-Arg maturation site, the present observations suggest that PACE4 is possibly a candidate proBMP convertase that acts during tooth formation.  (+info)

Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)

Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histological examinations of individual organs in Sp3(-/-) mice show a pronounced defect in late tooth formation. In Sp3 null mice, the dentin/enamel layer of the developing teeth is impaired due to the lack of ameloblast-specific gene products. Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy.  (+info)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)

Previous studies have demonstrated the presence of calbindin D28k in the ameloblasts derived from the inner enamel epithelium. The occlusal surfaces of the rodent molars partly lack the enamel covering, which is referred to as enamel-free area (EFA). In the present study, we compared the immunohistochemical localization of calbindin D28k-like immunoreactivity (CB-LI) in the cells at the EFA (EFA cells) and ameloblasts of the rat molar teeth at the light microscopic level. CB-LI was strong in the ameloblasts of the presecretory through the protective stages, while it was faint at the late secretory to transitional stages. However, some mature ameloblasts lacked the immunoreactivity. On the other hand, the majority of EFA cells showed distinct polarization and elongation that were absent in few cells at the early stage of EFA formation. At all stages, the EFA cells adjacent to the ameloblasts showed CB-LI, however, some cells adjacent to the mature ameloblasts lacked the reaction. Intensive CB-LI was demonstrated in EFA cells at the reduced enamel epithelium. These immunohistochemical findings suggest EFA cells have cytochemical properties similar to those of ameloblasts.  (+info)

*Tooth

These teeth are also known as aradicular teeth, and unlike humans whose ameloblasts die after tooth development, rodents ...

*Ameloblast

Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the ... The ameloblasts will only become fully functional after the first layer of dentin (predentin) has been formed by odontoblasts. ... Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross ... Ameloblasts are cells which secrete the enamel proteins enamelin and amelogenin which will later mineralize to form enamel, the ...

*Index of oral health and dental articles

Ameloblast • Ameloblastic fibroma • Ameloblastin • Ameloblastoma • Amelogenesis • Amelogenesis imperfecta • Amelogenin • ...

*Linear enamel hypoplasia

If the ameloblast cells do not recover from a disturbance, these ameloblasts cells will stop forming further enamel and results ... A single cell layer of ameloblasts develop enamel composition. Ameloblasts have six stages in their life cycle, which are ... Ameloblast cells form hard outermost layers for enamel forming surface crowns. Any systematic disturbance that disrupts the ... "Reconstructing impairment of secretory ameloblast function in porcine teeth by analysis of morphological alterations in dental ...

*Amelogenesis

Although dentin must be present for enamel to be formed, ameloblasts must also be for dentinogenesis to continue. A message is ... It is at this stage that a signal is sent from the newly differentiated ameloblasts back across the dentinoenamel junction (DEJ ... When this first layer is formed, the ameloblasts move away from the interface with dentin, allowing for the development of ... Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, ...

*ODAM (gene)

Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ODAM odontogenic, ameloblast asssociated [sic]". Retrieved 2013-03-31. Moffatt P, Smith CE, Sooknanan R, et al. ( ...

*BCL11B

Recent research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly ... "Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis". Proc. Natl. Acad. Sci. U.S.A. 106 (11): 4278-83. ...

*Tomes' process

More than one ameloblast contributes to a single prism. Tomes' processes are distinctly different from Tomes' fibers, which are ... During the synthesis of enamel, the ameloblast moves away from the enamel, forming a projection surrounded by the developing ... Tomes' processes are those projections and give the ameloblast a "picket-fence" appearance under a microscope. They are located ... Tomes' processes are a histologic landmark identified on an ameloblast, cells involved in the production of tooth enamel. ...

*Interrod enamel

All tooth enamel, including interrod enamel and enamel rods, is made by ameloblasts. However, interrod enamel is formed ...

*Enamel organ

Tooth enamel Ameloblast Tooth Tooth development Cate, A.R. Ten. Oral Histology: development, structure, and function. 5th ed. ...

*TFIP11

... localizes to the apical secretory pole of mouse ameloblasts". J Biol Chem. 275 (29): 22284-92. doi:10.1074/jbc.M000118200. PMID ...

*Human tooth

These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...

*Tuftelin

2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 ... localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284-92. doi:10.1074/jbc ...

*Inner enamel epithelium

This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. These ... will differentiate into Ameloblasts which are responsible for secretion of enamel during tooth development. The location of the ...

*AMBN

This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not ...

*Junctional epithelium

The ameloblasts also develop hemidesmosomes for the primary EA and become firmly attached to the enamel surface. However, the ... Before the eruption of the tooth and after enamel maturation, the ameloblasts secrete a basal lamina on the tooth surface that ...

*Molar Incisor Hypomineralisation

More recent evidence has suggested a relationship between respiratory diseases and oxygen shortage of the ameloblasts and MIH. ... due to interruption to the function of ameloblasts. Many factors have been suggested, such as genetics and medical problems ...

*FAM83H

MMP20 is responsible for the breakdown of extracellular matrix and plays a role in tissue remodeling in ameloblasts. mutations ...

*Enamel tufts

This is because they are formed by entrapment of odontoblast processes between ameloblasts prior to and during amelogenesis. ...

*Dentin dysplasia

... or differentiation are mainly due to atypical interaction between odontoblasts and ameloblasts. Histopathologically, deeper ...

*Enamel hypocalcification

Local trauma or abscess formation can adversely affect the ameloblasts overlying a developing crown, resulting in enamel ...

*Calcifying odontogenic cyst

3)Type 1C Ameloblast like proliferation in the connective tissue and lumen of the cyst may be seen. Unilocular radiolucency may ... Additionally, focal areas of stellate reticulum like cells are seen and near the basement membrane ameloblast-like cells may be ...

*Enamel pearl

... they may differentiate into fully functional ameloblasts and deposit enamel. Such droplets of enamel are called enamel pearls. ...

*Odontogenic tumor

Examples include: Adenomatoid odontogenic tumor Ameloblastoma, a type of odontogenic tumor involving ameloblasts Calcifying ...

*Mammal tooth

Unlike humans whose ameloblasts die after tooth development, rodents continually produce enamel and must wear down their teeth ...
The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development. Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell lineage. In Ctip2−/− mice, tooth morphogenesis appeared to proceed normally through the cap stage but developed multiple defects at the bell stage. Mutant incisors and molars were reduced in size and exhibited hypoplasticity of the stellate reticulum. An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. Perturbations of gene expression were also observed in the mandible of Ctip2−/− mice: expression of the ameloblast ...
Cells of the inner enamel epithelium located adjacent to the dental papilla mesenchymal cells, differentiate into early ameloblasts during the bell stage. Early ameloblasts differentiate into mature cells through pre-secretory and secretory stages. During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. In the secretory stage, the matrix proteins accumulate extracellularly and the tooth crown is formed ...
Objective: To observe the effect of fluoride overdose on the proliferation of the pure Wistar rats incisor ameloblasts. Material and Methods: Twenty healthy Wistar rats were randomly divided into 2 groups, Group I (the control) and Group II (receiving 50 mg/L F-). After 8 weeks treatment the AgNORs stain and TUNEL technique were used to analyze the effect of fluoride on the proliferation and apoptosis of ameloblasts. Results: Incremental lines in the incisors in Group II were clearly visible and eosinophilic granules had accumulated in the ameloblasts in the secretory stage. The number of AgNORs granules in the ameloblasts in the pre-secretory stage in Group II was lower than in Group I, and the difference was statistically relevant (p < 0.001); more ameloblasts experienced apoptosis or migrated in the secretory stage. Conclusion: Fluoride overdose can inhibit proliferation of the ameloblasts and accelerate their apoptosis, which is what is meant by fluorosis. ...
Sigma-Aldrich offers abstracts and full-text articles by [Juni Sarkar, Emil J Simanian, Sarah Y Tuggy, John D Bartlett, Malcolm L Snead, Toshihiro Sugiyama, Michael L Paine].
The bone matrix and tooth enamel are the hardest substances in the body, and both are formed through the mineralization of proteins secreted by osteoblasts and ameloblasts, respectively. One of the primary components of the bone matrix is collagen, which provides strength, as well as acts as a substrate for mineralization. Amelogenin is the main extracellular matrix protein secreted by ameloblasts and is important for both the inclusion of minerals and the proper structure of tooth enamel. Defects in the secretion or structure of these extracellular matrices compromise the strength and durability of the tissues. Two studies reveal distinct mechanisms of secretory dysregulation that affect proper mineralization of these tissues. Zhao et al. found that the trimeric intracellular cation channel Tric-b, which localizes to the endoplasmic reticulum (ER), was important to secretion of collagen by osteoblasts in mice. Mutations in TMEM38b, the human homolog of Tric-b, are associated with osteogenesis ...
The mineralized portions of teeth, the dentin and emel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts,…
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The effect of a 2 hour exposure to adriamycin (1 mg/litre) on alkaline phosphatase (ALPase) activity of the golden hamster 4-5 day old second maxillary molars (M2) was investigated in vitro. The molars were grown in BGJb medium containing 15% fetal bovine serum, glutamine (200 micrograms/ml), vitamin C (250 micrograms/ml), penicillin G (50 micrograms/ml), and streptomycin sulphate (30 micrograms/ml). The gas phase contained 50% O2 + 5% CO2 + 45% N2. The molars were supported on cellulosic membrane filters and grown for 3, 5, and 7 days at the medium-gas interface in a closed humidified chamber. Biochemical analysis indicated a steady increase in ALPase activity throughout this study in the control samples. However, after adriamycin treatment no increase in ALPase activity could be observed. The histochemical data showed that the increased activity in the control was confined to the peripheral pulp, sub-odontoblastic layer, stratum intermedium, ameloblasts and odontoblasts. Although these layers ...
For my french work, I drew a lot of books, here the entire list:. Glénat Editions:. -Raghnarok. Tome 1 : Dragon Junior. Tome 2 : Fées et Gestes. Tome 3 : Terreurs de la nature. Tome 4 : Légendes urbaines. Tome 5 : Tempus Fugit. Tome 6 : Casus Belli. -La Rubrique Scientifique. Tome 1. Tome 2. Tome 3. -Le Miya (with Reno, Julien Néel and Libon). -Womoks (only scenario, drawing by Reno). Tome 1 : Mutant, suspends ton vol…. Tome 2 : Le croiseur samuse. Tome 3 : Albon, les brutes et les truands. La boîte à bulles Edition:. -Le vœu de…. Tome 1 : Le vœu de Marc (coscenarist with Nicolas Wild, drawing by Lucie Albon). Tome 2 : Le vœu de Simon (coscenarist with Lucie Albon, drawing by Lucie Albon). -Amour et Désir (Collectif, seven pages under the alias Ella Forbin). -Delcourt Edition:. -Donjon (avec Lewis Trondheim et Joann Sfar au scénario, et Lucie Albon à la couleur). Tome 5 : Un mariage à part. Tome 6 : Retour en fanfare. -Notes (these are the compilations of all the entries of ...
For my french work, I drew a lot of books, here the entire list:. Glénat Editions:. -Raghnarok. Tome 1 : Dragon Junior. Tome 2 : Fées et Gestes. Tome 3 : Terreurs de la nature. Tome 4 : Légendes urbaines. Tome 5 : Tempus Fugit. Tome 6 : Casus Belli. -La Rubrique Scientifique. Tome 1. Tome 2. Tome 3. -Le Miya (with Reno, Julien Néel and Libon). -Womoks (only scenario, drawing by Reno). Tome 1 : Mutant, suspends ton vol…. Tome 2 : Le croiseur samuse. Tome 3 : Albon, les brutes et les truands. La boîte à bulles Edition:. -Le vœu de…. Tome 1 : Le vœu de Marc (coscenarist with Nicolas Wild, drawing by Lucie Albon). Tome 2 : Le vœu de Simon (coscenarist with Lucie Albon, drawing by Lucie Albon). -Amour et Désir (Collectif, seven pages under the alias Ella Forbin). -Delcourt Edition:. -Donjon (avec Lewis Trondheim et Joann Sfar au scénario, et Lucie Albon à la couleur). Tome 5 : Un mariage à part. Tome 6 : Retour en fanfare. -Notes (these are the compilations of all the entries of ...
Breast neoplasms are the second leading cause of cancer deaths of women in the United States. Recently, it has been shown by immunohistochemical staining of tumor biopsy tissue that nuclear localization of the odontogenic ameloblast associated protein (ODAM) correlated with staging and increased survival in patients, leading to the proposal of this protein as a novel biomarker in breast cancer. Further, ectopic expression of recombinant ODAM protein in the invasive breast carcinoma line MDA-MB-231 (231-ODAM) was shown to slow cell growth to 30-50% of that seen in control 231 cells, increase apoptosis, effect developmental change, and decrease the ability of cells to migrate or invade through extracellular matrix in transwell barrier assays. Further, this expression reduced the ability of these cells to form solid tumors by greater than 10-fold in immunodeficient mice, or establish tumor colonization of the lungs after tail vein injection. Herein, we show results of microarray and qRT-PCR data ...
A.F.I. - Weathered Tome Lyrics. Theyre coming round again Ive returned and theyve been waiting Their aged offererings received and returned Passed through wet eyes I t
Tooth enamel formation. Coloured scanning electron micrograph (SEM) of a freeze-fractured section through a tooth, showing the enamel-forming cell layer (green). This epithelium comprises a single layer of columnar cells called ameloblasts. The fracture plane passes up into the tooth from the enamel surface (orange, bottom left). The ameloblast layer has detached from the enamel in which it is normally embedded. Enamel is a hard ceramic layer that covers and protects the teeth. The other end of the ameloblasts originate in the internal tooth tissue (brown, across top). Magnification unknown. - Stock Image P486/0080
Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these proteins in the formation and regeneration of the junctional epithelium. ...
An opportunity exists for an Honors student to study the role of Platelet Derived Growth Factor Receptor (PDGFRa) cells during tooth development. The study will be a collaborative work with Profession Patrick Tam at Childrens Research Institute. PDGFRa is derived from neural crest and expressed in odontoblasts, ameloblasts of developing tooth, and mesenchymal cells of adult dental pulp. Characterisation of PDGFRa cells during embryonic development would help identify determinant factors that drive the cells towards dental fate, which may help to harness adult stem cells/progenitor cells into desired cell types that can be used for tissue repair. Genetic mouse models including conditional knockout mouse models will be used in this study.. Scholarship available. Contact Dr. Munira Xayamardan. Email: [email protected]; Phone 02 9351 8324; Mobile 0404345236. ...
Read Dampierre - Tome 03 Les Emissaires by Yves Swolfs with Rakuten Kobo. Alors que la Révolution triomphe à Paris, en Vendée le peuple résiste aux idéaux révolutionnaires qui bafouent coutume...
cdna chromosome:GRCm38:5:88456011:88468531:1 gene:ENSMUSG00000029288 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Ambn description:ameloblastin [Source:MGI Symbol;Acc:MGI:104655 ...
I dont! I have been lugging a copy of Anna Karenina around with me for ages (in fact, I have it here in my office with me now), and according to a dog-eared page, I am on p. 271. The problem? At this point I have not a damn clue what is going on. Who the heck is Sergey Ivanovich Koznyshev? I have no clue whatsoever. Do I start over? I started this book before law school, so I am averaging about 50 pages per year.. ReplyDelete ...
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Mice carrying a Y64H amelogenin mutation phenotypically mimic human amelogenesis imperfecta. Affected ameloblasts are characterised by the presence of abnormal cytoplasmic vesicles of retained amelogenin. Protein-protein binding studies using recombinant wild type and Y64H amelogenin revealed that the mutation increased amelogenin-amelogenin binding. This may drive intracellular aggregation of Y64H amelogenin, explaining the abnormal retention. Intracellular protein aggregation causes ER stress which triggers the UPR. The UPR attempts to restore proteostasis but as a last resort triggers apoptosis. SEM of affected enamel showed initially secreted enamel is normal; coincident with UPR in pro-survival mode. The final outer enamel is abnormal; indicative of UPR induced ameloblast apoptosis. Q-RT-PCR was used to measure ER stress related gene expression in affected ameloblasts. Expression levels of ER stress genes increased but not significantly (significance was reached in later studies by others ...
Dental enamel is the hardest mineralized tissue in the body and initially forms from a protein matrix. During enamel formation, ameloblasts secrete unique proteins into the extracellular space to direct mineralization of enamel crystallites. This specialized organic matrix contains the proteins amelogenin, ameloblastin, and enamelin. Amelogenin is the major enamel matrix protein secreted, comprising ~95% of the total matrix, yet after maturation and completion of amelogenesis, only ~1% of the initial organic matrix remains in mineralized enamel. Ameloblasts, being the only cells in close proximity to the organic matrix, most likely are responsible for the removal of proteinaceous matrix debris for proper enamel maturation. The rapid removal of enamel matrix proteins is poorly understood in the literature, principally because clathrin (the prototypical pathway for endocytosis) is expressed at very low levels in ameloblasts. Most of the historical record of endocytosis is focused on clathrin ...
Odontogenesis is governed by a complex network of intercellular signaling events between the dental epithelium and mesenchyme. This network leads to the progressive determination of tooth shape, and to the differentiation of these tissues into enamel-producing ameloblasts and dentin-producing odontoblasts respectively. Among the main signaling pathways involved in the regulation of tooth development, Bone Morphogenetic Protein (BMP), Sonic hedgehog (Shh) and Wingless-type MMTV integration site (Wnt) pathways have been reported to play significant roles. Recently, the phenotype of mice deficient in Epiprofin/Sp6 (Epfn) has been found to present striking dental abnormalities, including a complete lack of differentiated ameloblasts and consequently no enamel, highly altered molar cusp patterns and the formation of multiple supernumerary teeth. In this article, we review the interaction of Epfn with the BMP, Shh and Wnt pathways in the regulation of tooth development, based on the data obtained from the
We have studied the expression of transforming growth factor beta-1 (TGF-beta 1) RNA during mouse tooth development, using in situ hybridization and experimental tissue recombinations. Analysis of the serial sections revealed the appearance of local expression of TGF-beta 1 RNA in the dental epithelium at bud- staged teeth (13-day embryos). Just before transition to the cap stage, TGF-beta 1 RNA expression rapidly increased in the epithelial bud, and it also extended to the condensed dental mesenchyme. At cap stage (14- and 15-day embryos), there was an intense expression of TGF-beta 1 RNA in the morphologically active cervical loops of the dental epithelium. During early bell stage (16- and 17-day embryos), TGF-beta 1 RNA expression was detected in the inner enamel epithelium where it subsequently almost disappeared (18- day embryos). After birth TGF-beta 1 transcripts transiently appeared in these cells when they were differentiating into ameloblasts (1-day mice). The transcripts were lost ...
Waluyo, Soegeng (2016) Efek Sistemik Fluoride pada Pertumbuhan dan Perkembangan Jaringan Tubuh Anak. In: Pertemuan Ilmiah Nasional Ke 9 Ilmu Kedokteran Gigi Anak, Maret 2016, Yogyakarta. Waluyo, Soegeng (2013) Peran kalsium sebagai prevensi terjadinya hipoplasia enamel (The role of calcium on enamel hypoplasia prevention). Dental Journal, 46 (3). pp. 113-118. ISSN 1978-3728 Waluyo, Soegeng and ISMIYATIN, K and PURWANTO, B and MUKONO, I.S (2017) The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells. Folia Biologica Journal of Celluler and Molecular Biology, 63. pp. 31-34. Waluyo, Soegeng and Masyitah, Masyitah (2014) Management Children with multiple caries in variety treatment. In: Pertemuan Ilmiah Nasional Ilmu Kedokteran Gigi Anak VII., 8-9 February 2014, Surabaya. Waluyo, Soegeng and Nuraini, Prawati and Pudji Rahayu, Retno and Ismiyatin, Kun (2017) The Effect of NaF on the Existence of Ameloblasts and the Change of Tooth Dimension. Journal of ...
Medicine Journal in MJB authors are : Anas Falah Mahdee,Ahmed Ghanim Alhelal,John Whitworth,Jane Eastham,James Gillespie Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout Amelogenesis university of babylon journals in the repository for farther content please log to http://repository.uobabylon.edu.iq
The identification that amelogenin binds to CD63 [11] and LAMP1 [16] led us to hypothesize that amelogenin may be rapidly taken up by the ameloblast cell through receptor-mediated endocytosis [19]. The detailed characterization of the binding regions in amelogenin, CD63 and LAMP1 by the Y2H assay reveals that the region (P155LSPILPELPLEAW168) of amelogenin M180 is responsible for the interaction with CD63 through the domain specified by amino acids 165-205, LAMP1 through the domain specified by amino acids 226-251 and LAMP2 through the domain specified by amino acids 227-259. The binding region (residues 155-168) of amelogenin is hydrophobic, and is predicted to be largely disordered and accessible to the external environment. The region defined by amino acids 165-205 of CD63 is likely to be in a 7 shape within the mushroom-like structure of CD63 EC2.. All of the data presented in Table 2 were derived from the Y2H assays. No significant ambiguity clouded our interpretation, as smaller regions ...
Foetal tooth. Coloured light micrograph (LM) of a section through of an unerupted foetal tooth. The first set of teeth begin to develop around six weeks after conception. The permanent teeth begin to develop around a month after this. The foetal tooth is capped with a layer of enamel (orange), with a layer of dentine (cyan) beneath this. The larg pale region below these is the pulp. A layer of ameloblasts (purple) forming the enamel, and odontoblasts (brown) forming the dentine, are present. Bone of the jaw is seen at the left of the image. Magnification: x 40 when printed 10cm tall. - Stock Image C022/5093
SLC26A Gene Family Participate in pH Regulation during Enamel Maturation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
AMBN - AMBN (untagged)-Human ameloblastin (enamel matrix protein) (AMBN) available for purchase from OriGene - Your Gene Company.
Calcagno, C.; Evangelisti, F.; Zunin, P.; D.E.idio, M.G.; Nardi, S., 1995: Identification of the maturation stage of grain of some cereals characterized by a higher content of essential amino acids
original description Delle Chiaje, Stefano 1841 & 1844. [POLYCHAETA context] Descrizione e Notomia degli Animali Invertebrati della Sicilia Citeriore osservati vivi negli anni 1822-1830. [Tome 1, 98 pp.; Tome 2, 146 pp; Tome 3, 142 pp [Molluschi Acefali, Bracciopedi, Cirropedi, Crostacei, Anellosi]; Tome 4, 142 pp.; Tome 5, 165 pp. [1841, incl. Annelosi Afroditici]; Tome 6-7, pl. 1-173 [1841], pl. 174-181 [1844]; Tome 8 (Appendici, osservazioni critiche, indice generale), 48 pp. [1844] Napoli, Stabilimento Tipografico di C. Batelli e Co., available online at http://www.biodiversitylibrary.org/bibliography/10031 ...
abst, Adrast, agrest, agromiast, akatyst, Alcest, aleuroplast, alkahest, alkotest, ameloblast, ametyst, aminoplast, amnioblast, amyloplast, anapest, angioblast, angst, Antychryst, antychryst, antypast, antyrost, antyspast, aoryst, apost, Ast, asyst, atest, audiotekst, Augst, august, August, autopast, awanpost, azbest, Babimost, bakist, balast, balist, batyst, Belfast, berest, Best, biust, blastocyst, bombast, Brest, brzost, burst, canast, celest, chełst, chiroplast, chlast, chloroplast, chlust, chłodnorost, chłost, chondroblast, choroplast, chromoplast, chrust, chrząstkozrost, chrzest, chrzęst, chust, chwast, chwost, ciast, ciepłorost, cist, Coast, conquist, crust, cyst, cytoblast, czelest, czworolist, diatest, Dobrogost, dopust, dost, drapichrust, drzewipest, dst, dunst, duroplast, dygest, dyzgust, East, Economist, Egist, ektoblast, elajoplast, elastoplast, embrioblast, endoblast, enkaust, Enquist, entoblast, epiblast, Ernest, Ernst, erytroblast, est, Everest, Ewaryst, fagocytoblast, ...
abst, Adrast, agrest, agromiast, akatyst, Alcest, aleuroplast, alkahest, alkotest, ameloblast, ametyst, aminoplast, amnioblast, amyloplast, anapest, angioblast, angst, antychryst, Antychryst, antypast, antyrost, antyspast, aoryst, apost, Ast, asyst, atest, audiotekst, Augst, August, august, autopast, awanpost, azbest, Babimost, bakist, balast, balist, batyst, Belfast, berest, Best, biust, blastocyst, bombast, Brest, brzost, burst, canast, celest, chełst, chiroplast, chlast, chloroplast, chlust, chłodnorost, chłost, chondroblast, choroplast, chromoplast, chrust, chrząstkozrost, chrzest, chrzęst, chust, chwast, chwost, ciast, ciepłorost, cist, Coast, conquist, crust, cyst, cytoblast, czelest, czworolist, diatest, Dobrogost, dopust, dost, drapichrust, drzewipest, dst, dunst, duroplast, dygest, dyzgust, East, Economist, Egist, ektoblast, elajoplast, elastoplast, embrioblast, endoblast, enkaust, Enquist, entoblast, epiblast, Ernest, Ernst, erytroblast, est, Everest, Ewaryst, fagocytoblast, ...
Craft a Tome of Illusions: Secrets of the Shado-Pan. This is an Enchanting Ability. A spell from World of Warcraft: Legion. Always up to date.
H. Lesot, R. Peterkova, R. Schmitt, J. M Meyer, L. Viriot, J. L Vonesch, B. Senger, M. Peterka, and J. V Ruch (1999) Int J Dev Biol, 43(3):245-54.. ...
I had my last period on Aug 28th. Today I was in the gym after a long tome and I was doing some exercises for the lower abdomen. LAter on I noticed some
Chronic fluoride over-exposure during pre-eruptive enamel development can cause dental fluorosis. Severe dental fluorosis is characterized by porous, soft enamel that is vulnerable to erosion and decay. The prevalence of dental fluorosis among the population in the USA, India and China is increasing. Other than avoiding excessive intake, treatments to prevent dental fluorosis remain unknown. We previously reported that high-dose fluoride induces endoplasmic reticulum (ER) stress and oxidative stress in ameloblasts. Cell stress induces gene repression, mitochondrial damage and apoptosis. An aromatic fatty acid, 4-phenylbutyrate (4PBA) is a chemical chaperone that interacts with misfolded proteins to prevent ER stress. We hypothesized that 4PBA ameliorates fluoride-induced ER stress in ameloblasts. To determine whether 4PBA protects ameloblasts from fluoride toxicity, we analyzed gene expression of Tgf-β1, Bcl2/Bax ratio and cytochrome-c release in vitro. In vivo, we measured fluorosis levels, enamel
Looking for online definition of enamel epithelium in the Medical Dictionary? enamel epithelium explanation free. What is enamel epithelium? Meaning of enamel epithelium medical term. What does enamel epithelium mean?
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
The pulp space is almost totally obliterated in the incisal end of a mandibular rat incisor. Repeated shortening of the incisor has been shown to increase the pulp space below the alveolar bone level; however, little is known about that above the alveolar bone level. This study investigated the changes in the pulp space superior to the bone level after rendering the incisor unimpeded for a period of three weeks. A desktop micro-computed tomography scanning unit, which is non-invasive, non-destructive, accurate, less technique sensitive and less time consuming than conventional methods, was used to calculate the volume of the pulp space. The results showed that the pulp size increased 140% at a level 3 mm below the alveolar bone margin and more than 700% at a level 2.5 mm above the alveolar bone. Moreover, the bone level of the unimpeded incisor was found to move incisally 0.4-0.5 mm; while deposition of dentine on the mesial and distal aspects of the pulp space were affected differently to that ...
Learn how to call Sao Tome from Nigeria. Out complete resource guide gives you the Sao Tome country code & Nigerian dialing code to make your international calls.
Perform reliable qPCR with Bio-Rads pre-validated Odam primer pair, for the Mouse genome. Designed for SYBR Green-based detection.
Learn how to call Ethiopia from Sao Tome. Out complete resource guide gives you the Ethiopia country code & Sao Tomean dialing code to make your international calls.
Tome of Morytha is a key item in Xenoblade Chronicles 2, it is an ancient text on the land of Morytha and it is adenines special treasure, shes willing t...
Adult literacy rate is the percentage of people ages 15 and above who can, with understanding, read and write a short, simple statement on their everyday life.This page has the latest values, historical data, forecasts, charts, statistics, an economic calendar and news for Literacy rate - adult female (% of females ages 15 and above) in Sao Tome and Principe.
9044985( Plecoptera: Nemouridae) with a download Dans les villages. l\Anti jole, tome 2 1998 to the Zonation from Guizhou Province, China. 9044985 Baumann, 1975( Plecoptera: Nemouridae) from China. damage in the carbon of Plecoptera poems.
Just dont know how my brain works. Whatever I draft in there is as wispy as the wind and vamooses just as easily. So, cant think of what I wanted to say, especially after reading this. Oh, I think I wanted to say something about Borat ... movies best enjoyed knowing that the hapless folks…
Hello again GitP. Long time, no post. A while back I started working on a skills rewrite. D&D 3.x placed a high value on skills but never actually delivered anything with them. You could use them for cool things with epic rules, but no one ever did because 1) epic had its own problems and 2) people already had items to do the things for them anyway. Later classes suffer from this less than early classes, but theyre also more narrow than I prefer. So I was annoyed at the state of things,
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Vieillot, L.J.P. 1817. Nouveau Dictionnaire dHistoire naturelle, appliquée aux arts, à lagriculture, à léconomie rurale et domestique, à la médecine, etc. Par une société de naturalistes et dagriculteurs. Avec des figures tirées des trois règnes de la nature. Tome 8. 610 pp. +10 tt. Déterville, Paris. P.271 BHL Reference page. ...
Amelotin is an enamel-specific gene product, and its expression under normal circumstances is limited to maturation-stage (or late-stage) amelogenesis. The altered pattern of amelotin gene expression is achieved by creating transgenic animals in which the amelogenin gene promoter is used to drive amelotin. This study sets out to analyze transgenic animals in which amelotin is expressed throughout all stages of enamel formation (amelogenesis). This thesis will include an introduction and background in tooth development (including amelogenesis), and present results demonstrating animal genotype confirmation, transgene expression profiles by immunohistochemical and Western analysis and enamel phenotype using electron microscopy. We hypothesized that "The transgene will be functional, and that the amelotin transgene will be expressed throughout all stages of amelogenesis, resulting in an abnormal enamel structure." Data from immunohistochemical studies showed amelotin to be expressed throughout all ...
When you are building an oral health treatment plan, one of the best things that you can do is to take steps to preserve as much of your existing health dental structure as possible. Because dental enamel is designed to be strong and resistant to damage, the more that you can do to preserve dental enamel the better it is for your smile.. Today our OFallon dentists are sharing some more information about enamel; we hope that this empowers you to care for your teeth!. Dental enamel is the outermost layer of your smile. Every tooth is actually comprised of multiple layers: the dental enamel, the dentin, and then finally the dental pulp. Of these three layers the dental enamel is the least porous and the most durable.. Additionally, dental enamel does not have nerves in it. This is what allows you to chew and drink your favorite beverages without experiencing pain and sensitivity.. In order to maintain strong and healthy dental enamel, you want to make sure that you are drinking plenty of water, ...
Loss-of-function mutations in the Ca(2+) release-activated Ca(2+) channel genes ORAI1 and STIM1 abolish store-operated Ca(2+) entry (SOCE) and result in ectodermal dysplasia with amelogenesis imperfecta. However, because of the limited availability of patient tissue, analyses of enamel mineralization or possible changes in ameloblast function or morphology have not been possible. Here, we generated mice with ectodermal tissue-specific deletion of Stim1 ( Stim1 cKO [conditional knockout]), Stim2 ( Stim2 cKO), and Stim1 and Stim2 ( Stim1/2 cKO) and analyzed their enamel phenotypes as compared with those of control ( Stim1/2(fl/fl)) animals. Read More ...
Our results suggest that some coding exons present in the coelacanth AMTN and in most of the tetrapods analyzed here derive from those of an ancestral SCPP, from which AMTN and EMPs originated after duplication. Indeed, AMTN exons 2a and 2b are homologous to exons 2 and 3 (exon 4 and 5 in ENAM) of all SCPPs, respectively. In addition, AMTN shares several other characteristics with all EMPs, i.e. the signal peptide encoded by exon 2a, the conserved Ser-X-Glu motif (putative phosphorylation site) encoded by exon 2b, and the presence of a variable region encoded by a large exon, as previously observed by Kawasaki and Weiss [6].. The presence of AMTN exon 2b in salamander cDNA and its absence in clawed frog, for which gDNA and cDNA sequences are available, indicates that this exon has been lost either early in the anuran lineage (no AMTN sequences available in other frog lineages), or later in the lineage leading to Pipidae (Figure 7). Exon 2b also lacks in mammalian AMTN, a finding indicating that ...
THE ANATOMICAL RECORD 222:191-200 (1988) Radioautographic Demonstration of Receptors for Epidermal Growth Factor in Various Cells of the Oral Cavity MOON-IL CHO, YU LIN LEE, AND PHILIAS R. GARANT Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, New York 11794-8700 ABSTRACT Mouse iodinated epidermal growth factor (EGF)was localizedby light and electron microscopic radioautography in basal cells of oral epithelium, papillary cells of the enamel organ, periodontal ligament fibroblasts, preodontoblast precursor cells, and preosteoblasts of the alveolar bone of 13-day-old Sprague-Dawleyrats. The specificity of binding in these cells was suggested by an observed reduction of about 90% in the labeling when excess unlabeled EGF was injected along with the 125I-EGF. In contrast, fully differentiated cells, such as ameloblasts. odontoblasts, and osteoblasts, were only poorly labeled. Quantitative analysis of the light microscopic ...
The experiments reported here were undertaken primarily to investigate further the histological changes occurring in the enamel organ of the rats incisor tooth during vitamin E deficiency. These changes were originally described by Irving (1942) and have been confirmed in general by Granados, Mason & Dam (1945, 1946) and by Pindborg (7950, 1952). It was, however, found by the present writers, usinga diet based on that of Gillman, Gilbert, Gillman & Spence (1952), that extreme changes in the enamel organ, avertable by vitamin E, could be produced in 21 days or less, whereas the changes described by the other authors took much longer to develop and were less extensive. In an attempt to determine further the effects of other dietary factors upon the enamel organ, certain additional findings seemed to be of significance. The present paper is concerned chiefly with these, and an account of the histological aspect is being prepared for publication. In particular it was found that the vitamin content ...
Though the major protein players have been identified and the high-resolution structure of enamel has been obtained, the process of its formation remains difficult to piece together because of its complexity, and is compounded by results from different laboratories that do not always reconcile well with each other. Multiple attempts to engineer artificial enamel have failed to reproduce the macromolecular interweaving structure of enamel rods or recapitulate the unique mechanical properties of natural enamel. A static in vitro method involving organic and inorganic molecular components lacks the dynamic variables that cells provide.. In order to produce enamel biomimetically, knowledge of the detailed mechanisms of amelogenesis are needed and would require cell lines with reproducible, predictable and physiologically-relevant properties. Addressing the lack of appropriate cell lines from presecretory to maturation stages would allow examination of essential molecular processes- such as ion and ...
MicroRNAs (miRNAs) are an abundant class of noncoding RNAs that are believed to be important in many biological processes through regulation of gene expression. Little is known of their function in tooth morphogenesis and differentiation. MicroRNA-214 (miR-214), encoded by the polycistronic Dnm30os gene, is highly expressed during development of molar tooth germ and was selected as a target for silencing with anti-miR-214. Mandibular injection of 1-100 pmol of anti-miR-214 close to the developing first molar in newborn mice resulted in significant decrease in expression of miR-214, miR-466h, and miR-574-5p in the tooth germ. Furthermore, levels of miR-199a-3p, miR-199a-5p, miR-690, miR-720, and miR-1224 were significantly increased. Additionally, the expression of 863 genes was significantly increased and the expression of 305 genes was significantly decreased. Among the genes with increased expression was Twist-1 and Ezh2, suggested to regulate expression of miR-214. Microarray results were ...
This small, poor island economy has become increasingly dependent on cocoa since independence in 1975. Cocoa production has substantially declined in recent years because of drought and mismanagement, but strengthening prices helped boost export earnings in 2003. Sao Tome has to import all fuels, most manufactured goods, consumer goods, and a substantial amount of food. Over the years, it has had difficulty servicing its external debt and has relied heavily on concessional aid and debt rescheduling. Sao Tome benefited from $200 million in debt relief in December 2000 under the Highly Indebted Poor Countries (HIPC) program, and is expected to benefit from an additional round of HIPC debt relief in early 2006, to help bring down the country´s $300 million debt burden. In August 2005, Sao Tome signed on to a new 3-year IMF Poverty Reduction and Growth Facility (PRGF) program worth $4.3 million. Considerable potential exists for development of a tourist industry, and the government has taken steps ...
Hello My (almost) 3yo son is missing baby lower incisor tooth. Is this something I should be looking to take action on now or wait and see if a permanent
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Perform reliable qPCR with Bio-Rads pre-validated ODAM primer pair, for the Rhesus Monkey genome. Designed for SYBR Green-based detection.
Coucou, je viens de tomber sur votre blog. ma fille de 10 ans adore les carnets de Cerise. elle a déjà les 2ers tomes et je vois que le 3ème sera bientôt dispo. joli cadeau de Noël que jai hâte de lui faire. Je suis enseignante en maternelle, jai des élèves de 6 ans et ils sont tombés sous le charme de Cerise. Jai hâte aussi de leur raconter la 3ème histoire. Vos dessins sont magnifiques et on pénètre dans un univers fabuleux! Jespère quil y aura encore beaucoup dhistoires de Cerise. ...
Coucou, je viens de tomber sur votre blog. ma fille de 10 ans adore les carnets de Cerise. elle a déjà les 2ers tomes et je vois que le 3ème sera bientôt dispo. joli cadeau de Noël que jai hâte de lui faire. Je suis enseignante en maternelle, jai des élèves de 6 ans et ils sont tombés sous le charme de Cerise. Jai hâte aussi de leur raconter la 3ème histoire. Vos dessins sont magnifiques et on pénètre dans un univers fabuleux! Jespère quil y aura encore beaucoup dhistoires de Cerise. ...
China on Thursday dismissed accusations from Taiwan that it engaged in dollar diplomacy to get Sao Tome and Principe to ditch ties with the self-ruled island, saying a petty Taiwan was besmirching Chinas good name.
Tooth development or odontogenesis is the complex process by which teeth form from embryonic cells, grow, and erupt into the mouth. For human teeth to have a healthy oral environment, all parts of the tooth must develop during appropriate stages of fetal development. Primary (baby) teeth start to form between the sixth and eighth week … Read more ...
At my first appointment with Dr Check, he did a "smear" of my cervical cells to see if the progesterone in my body had converted the cells. My cells were so highly estrogenized, and not at all progesteronized, that he suspected I had not ovulated yet. I KNEW my period was coming the next day. He said, "If thats so, then your body is WAY off." Sure enough, my period came the next day. Additionally, an ultrasound at this same appointment revealed that my uterine lining (endometrium) was still a triple-stripe proliferative stage lining. It had not converted to the secretory stage lining. I saw it myself, and was very confused. I thought, well, maybe because its the first cycle after surgery and my body is just off ...
At my first appointment with Dr Check, he did a "smear" of my cervical cells to see if the progesterone in my body had converted the cells. My cells were so highly estrogenized, and not at all progesteronized, that he suspected I had not ovulated yet. I KNEW my period was coming the next day. He said, "If thats so, then your body is WAY off." Sure enough, my period came the next day. Additionally, an ultrasound at this same appointment revealed that my uterine lining (endometrium) was still a triple-stripe proliferative stage lining. It had not converted to the secretory stage lining. I saw it myself, and was very confused. I thought, well, maybe because its the first cycle after surgery and my body is just off ...
A friend sent me an obituary today. Its the usual kind of viral e-mail thing that gets forwarded and forwarded to e-mail inboxes around the world. This particular one was entitled London Times Obituary of the late Mr. Common Sense. While I appreciate the opinion regarding the apparent loss of common sense in our modern…
This item is purchased during Noblegarden with 75 Noblegarden Chocolates. You must be a mage to purchase the book and although you can purchase it at low level, you cannot learn it until level 60. The book is BoP. ...
This item is purchased during Noblegarden with 75 Noblegarden Chocolates. You must be a mage to purchase the book and although you can purchase it at low level, you cannot learn it until level 60. The book is BoP. ...
Journal Dune Peste - Tome 4 Y A Pas De Hasard... Ledda: Récits De Mythologie Nordique Star Wars : Docteur Aphra T1 Moi Quand Je Me Réincarne En Slime Tome 2 : Révolutionner Sa Vie Affective
Use them as prompts, not as an overload of information. People will be caught up trying to read everything and not listening to you, or they just wont bother. The more pictures, diagrams and tables you use the better! Tables can also be a handy way of including information if you have a word limit. ...
That tome of doom was followed up with the imaginatively titled "Terminal and scared-UPDATE" Why this thread has survived is beyond me. One thing that cannot be argued, Kman has defied all known medical science. To survive two years with total organ failure is a first, and I sincerely hope he has donated his carcass to medical science, much can be learned. Maybe we will be informed when he checks out, but dont be at all surprised if we continue to hear from him. ...
Brian cracks open the massive Tezuka tome by Harvey-award-winning author and pleasant lady Helen McCarthy to challenge the eternal question: Why dont I like Tezuka as much as I should?
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Definition of Dental enamel permeability with photos and pictures, translations, sample usage, and additional links for more information.
Dana Branzeis is a PI at the Institute of Molecular Oncology Foundation (IFOM) in Milan, Italy, where her lab investigate mechanistic interplay of DNA damage response and regulatory pathways of chromosome structure during replication. In an interview, she shares why hard work and humility are key to a successful career.. Look out for First Person, our new interview series with early-career researchers. In this issue, we hear from Brandy Hyndman and Mathieu Crupi, Jinhang Hu and Yi-Wen Xu.. ...
The actions of alpha-tocopherol and protein upon the incisor tooth of the rat, and the influence of vitamin A upon alpha-tocopherol ...
Looking for Amyloblast? Find out information about Amyloblast. One of the columnar cells of the enamel organ that form dental enamel in developing teeth Explanation of Amyloblast
Enamel is the first and main line of defense against dental decay, and its proper formation is a prerequisite for strong, healthy teeth. Abnormalities in the mo...
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Have you ever wondered about tooth enamel? What is it? How important is it? How can you protect it? Here are the answers to all… Read more at Colgate.com
Tome este medicamento por vía oral con un vaso lleno de agua. Siga las instrucciones de la etiqueta del medicamento. Si toma una dosis de 400 mg a la vez o si el medicamento le produce malestar estomacal, tómelo con alimentos. Trate de no acostarse por lo menos 10 minutos después de tomar este medicamento. Tome su medicamento a la misma hora todos los días. No tome más medicamento que lo indicado. La utilización prolongada puede aumentar el riesgo de sufrir un ataque cardiaco o un derrame cerebral.. Su farmacéutico le dará una Guía del medicamento especial con cada receta y relleno. Asegúrese de leer esta información cada vez cuidadosamente.. Hable con su pediatra para informarse acerca del uso de este medicamento en niños. Puede requerir atención especial.. Sobredosis: Póngase en contacto inmediatamente con un centro toxicológico o una sala de urgencia si usted cree que haya tomado demasiado medicamento.. ATENCIÓN: Este medicamento es solo para usted. No comparta este ...
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Amelogenesis imperfecta (AI) is a group of inherited defects of dental enamel formation that show both clinical and genetic heterogeneity [1]. In its mildest form, AI causes discoloration, while in the most severe presentation the enamel is hypocalcified causing it to be abraded from the teeth shortly after their emergence into the mouth [2]. Both the primary and permanent dentitions may be affected. Enamel findings in AI are highly variable, ranging from deficient enamel formation to defects in the mineral and protein content [3]. Four main types of AI have been described: hypoplastic, hypocalcified, hypomaturation and hypomaturation-hypoplastic with taurodontism [4].. The AI phenotypes vary widely depending on the specific gene involved, the location and type of mutation, and the corresponding putative change at the protein level [5]. Different inheritance patterns such as X-linked, autosomal dominant and autosomal recessive types have been reported and 14 subtypes of AI are recognized ...
Amelogenesis imperfecta is an inherited defect of dental enamel formation that shows both clinical and genetic heterogeneity. In the hypoplastic type of AI, the enamel is of normal hardness but does not develop to normal thickness. The thinness of the enamel makes the teeth appear small. Radiographically, enamel contrasts normally from dentin. The surface of the enamel can vary, showing smooth, rough, pitted, or local forms (Witkop, 1988).
We have used synchrotron x-ray diffraction to study the crystal orientation in human dental enamel as a function of position within intact tooth sections. Keeping tooth sections intact has allowed us to construct 2D and 3D spatial distribution maps of the magnitude and orientation of texture in dental enamel. We have found that the enamel crystallites are most highly aligned at the expected occlusal points for a maxillary first premolar, and that the texture direction varies spatially in a three dimensional curling arrangement. Our results provide a model for texture in enamel which can aid researchers in developing dental composite materials for fillings and crowns with optimal characteristics for longevity, and will guide clinicians to the best method for drilling into enamel, in order to minimize weakening of remaining tooth structure, during dental restoration procedures. ...
Detail of the period when the root sheath cells (blue) secrete enamel matrix proteins. Following formation of the protein matrix on the surface of the mineralizing dentin, cementoblasts (Red) start producing cementum (Light blue) which anchors collagen fibers.. The Next Generation. In the mid 1980s, a revolutionary breakthrough in the basic biology of tooth development took place at the Karolinska Institutes department of Oral Pathology in Stockholm. The discovery revealed a native complex of enamel matrix proteins and the key if not crucial , role they play in the development of tooth-supporting tissues. These enamel related proteins mediate the formation of acellular cementum on the root of the developing tooth, providing a foundation for all of the necessary tissues associated with a functional periodontal attachment.. This groundbreaking discovery has fueled the development of a new generation in periodontal therapy, and makes the recreation of lost tooth support an attainable goal in the ...
The bell stage is known for the histodifferentiation and morphodifferentiation that takes place. The dental organ is bell-shaped during this stage, and the majority of its cells are called stellate reticulum because of their star-shaped appearance.. THE BELL STAGE IS DIVIDED INTO EARLY BELL STAGE & LATE BELL STAGES. Continue reading →. ...
Looking for online definition of tooth germ in the Medical Dictionary? tooth germ explanation free. What is tooth germ? Meaning of tooth germ medical term. What does tooth germ mean?
Tooth enamel is the hardest substance of our body, composed entirely of the mineral apatite deposited on a substrate of three unique enamel matrix proteins.
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Hi Green_Dragon! I am currently in the process of splitting material like prestige classes out of four very long articles (Tome of Necromancy (3.5e Sourcebook), Tome of Fiends (3.5e Sourcebook), Dungeonomicon (3.5e Sourcebook), Races of War (3.5e Sourcebook)) into their own articles, for easier digestion and use/reference by people. Unfortunately, while doing so, Ive run into a couple of namespace conflicts. Im worried about more namespace conflicts and namespace pollution in the future; so I was wondering if instead of, say, (DnD Prestige Class) appended onto prestige classes, I could use something like (Tome Prestige Class) as people often call those four works "The Tomes". I am given to understand that there are scripts that automagically add prestige classes to the list of homebrew prestige classes when new prestige classes are made. I am also given to understand that this only works with the (DnD Prestige Class) namespace. Is my understanding correct? If I can use the new namespace, is it ...
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Enamel shaping is like a subtle "makeover" for your teeth. Enamel shaping is the process of shaping your natural teeth to improve their overall appearance.. Enamel shaping works best when teeth are only slightly crowded or uneven.. Enamel shaping is usually quick and painless. Anesthesia is not necessary and the results can be seen immediately.. ...
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Abnormal environmental or physical conditions can interfere with the development of tooth enamel, causing it to take on a discolored, pitted or otherwise unusual appearance.
Mutations in the AMELX, ENAM, MMP20, KLK-4, FAM83H, WDR72, C4orf26, SLC24A4 LAMB3 and ITGB6 genes have been found to cause amelogenesis imperfecta (non-syndromic form). AMELX and ENAM encode extracellular matrix proteins of the developing tooth enamel and KLK-4 and MMP20 encode proteases that help degrade organic matter from the enamel matrix during the maturation stage of amelogenesis. SLC24A4 encodes a calcium transporter that mediates calcium transport to developing enamel during tooth development. Less is known about the function of other genes implicated in amelogenesis imperfecta.. Researchers expect that mutations in further genes are likely to be identified as causes of amelogenesis imperfecta.. Types include:. Amelogenesis imperfecta can have different inheritance patterns depending on the gene that is altered. Mutations in the ENAM gene are the most frequent known cause and are most commonly inherited in an autosomal dominant pattern. This type of inheritance means one copy of the ...
So, how do babys teeth grow ? The baby teeth actually starts growing during the 6th week in the mothers uterus. These baby teeth growth starts with the Bell shape tooth germ. This Bell shape structure seen is actually the enamel organ, which will eventually grow into a baby teeth. As you can see the enamel organ or tooth germ contains numerous cells. These cells will continue to grow and differentiate into different and more advance cells to form the tooth. The outer and inner enamel organ eventually forms the outer casing of the tooth called the enamel layer. Where else the dental papilla cells will form the inner section of the tooth known as the pulp chamber. The permanent tooth bud will continue to grow into the permanent teeth after the baby tooth eruption is completed in the mouth.. ...

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNASCtip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS

Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis Message Subject (Your Name) has sent you a message ... Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Olga Golonzhka, Daniel Metzger, Jean-Marc Bornert, ...
more infohttps://www.pnas.org/content/early/2009/02/25/0900568106.abstract

Early Ameloblasts Development in the Dental Enamel - LifeMap DiscoveryEarly Ameloblasts Development in the Dental Enamel - LifeMap Discovery

... differentiate into early ameloblasts during the bell stage. Early ameloblasts differentiate into mature cells through pre- ... During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. In ...
more infohttps://discovery.lifemapsc.com/in-vivo-development/tooth/dental-enamel/early-ameloblasts

IJERPH  | Free Full-Text | Fluoride Consumption and Its Impact on Oral Health | HTMLIJERPH | Free Full-Text | Fluoride Consumption and Its Impact on Oral Health | HTML

The impact of fluoride on ameloblasts and the mechanisms of enamel fluorosis. J. Dent. Res 2009, 88, 877-893. [Google Scholar] ... Multiple mechanisms, including direct fluoride-related effects on ameloblasts (secretory and maturation phases), indirect ...
more infohttp://www.mdpi.com/1660-4601/8/1/148/htm

From pulpal stem cells to tooth repair: an emerging field for dental tissue engineering | Evidence-Based Endodontics | Full TextFrom pulpal stem cells to tooth repair: an emerging field for dental tissue engineering | Evidence-Based Endodontics | Full Text

Differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned ... Then, dental mesenchyme generates signals promoting the maturation of developing ameloblasts. Conceptually, tooth regeneration ... were shown to be capable in vitro to express ameloblast-specific proteins such as ameloblastin, amelogenin (Ning et al. 2010), ... Epithelial cells are at the root of enamel-forming ameloblasts. Ectomesenchymal cells give rise to (i) odontoblasts, which ...
more infohttps://evidencebasedendodontics.springeropen.com/articles/10.1186/s41121-016-0002-x

MJB Journal : Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout...MJB Journal : Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout...

Note that the boundary of the ameloblast and enamel is indentified by the dotted lines, as the ameloblasts, in this region, do ... in the ameloblasts and papillary layer. Note that NOS-IR is concentrated in the basal region of the ameloblasts in the late ... Ameloblasts, throughout the enamel-genesis, have been found to express NOS-IR which provide a clue that ameloblasts may have a ... The ameloblasts, particularly in their apical region, also showed NOS-IR. The nuclei of the ameloblasts were located in the ...
more infohttp://www.medicaljb.com/article.aspx?jrid=1280

Exclusion of known gene for enamel development in two Brazilian families with amelogenesis imperfecta | Head & Face Medicine |...Exclusion of known gene for enamel development in two Brazilian families with amelogenesis imperfecta | Head & Face Medicine |...

Some of the cleavage products accumulate in the enamel layer, while others are either degraded or reabsorbed by ameloblasts [9 ... Recently a novel gene coding for an ameloblast-specific protein, amelotin, was mapped close to the amelobastin and enamelin ... Our results indicate that additional locus coding for genes involved in ameloblast cytodifferentiation and function remain ... Ameloblast-specific Protein. J Dent Res. 2005, 84 (12): 1127-1132.View ArticlePubMedGoogle Scholar. ...
more infohttps://head-face-med.biomedcentral.com/articles/10.1186/1746-160X-3-8

ameloblastameloblast

... - Ameloblasts are cells that deposit enamel, the hard outer most layer that forms the chewing surface.Ameloblasts ... ameloblast. noun Etymology: obsolete amel enamel (Middle English, ultimately from Old French esmail) + -o- + -blast - more at ... ameloblast - ameloblastic, adj. /am euh loh blast /, n. Anat. one of a layer of enamel secreting cells covering the dentin of a ... ameloblast - One of the columnar epithelial cells of the inner layer of the enamel organ of a developing tooth, concerned with ...
more infohttp://en.academic.ru/dic.nsf/mwc/1850/ameloblast

Frontiers | Immunocytochemical Localization of Claudin-1 in the Maturation Ameloblasts of Rat Incisors | PhysiologyFrontiers | Immunocytochemical Localization of Claudin-1 in the Maturation Ameloblasts of Rat Incisors | Physiology

Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts ( ... Distal junction area of ruffle-ended ameloblasts (RA) and the Golgi apparatus of a sub-population of smooth-ended ameloblasts ( ... Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the ... Since it has been shown that ameloblasts repeatedly alternate between an SA and an RA morphology during enamel maturation, the ...
more infohttps://www.frontiersin.org/articles/10.3389/fphys.2010.00150/full

ODAM - Odontogenic ameloblast-associated protein precursor - Homo sapiens (Human) - ODAM gene & proteinODAM - Odontogenic ameloblast-associated protein precursor - Homo sapiens (Human) - ODAM gene & protein

Odontogenic ameloblast-associated proteinAdd BLAST. 264. Amino acid modifications. Feature key. Position(s). DescriptionActions ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ... "Odontogenic ameloblast-associated protein (ODAM) Mediates Junctional Epithelium Attachment to Tooth via Integrin-ODAM-Rho ...
more infohttps://www.uniprot.org/uniprot/A1E959

Ameloblast - WikipediaAmeloblast - Wikipedia

Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the ... The ameloblasts will only become fully functional after the first layer of dentin (predentin) has been formed by odontoblasts. ... Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross ... Ameloblasts are cells which secrete the enamel proteins enamelin and amelogenin which will later mineralize to form enamel, the ...
more infohttps://en.wikipedia.org/wiki/Ameloblast

Nuclear Odontogenic Ameloblast-Associated Protein (ODAM) Correlates with Melanoma Sentinel  Lymph Node MetastasisNuclear Odontogenic Ameloblast-Associated Protein (ODAM) Correlates with Melanoma Sentinel Lymph Node Metastasis

... for the presence of the odontogenic ameloblast-associated protein (ODAM). Within these patient tissues we have observed a ... H. K. Lee, D. S. Lee, H. M. Ryoo, J. T. Park, S. J. Park, H. S. Bae, M. I. Cho and J. C. Park, "The Odontogenic Ameloblast- ... D. P. Kestler, J. S. Foster, S. D. Macy, C. L. Murphy, D. T. Weiss and A. Solomon, "Expression of Odontogenic Ameloblast- ... S. Siddiqui, C. T. Bruker, D. P. Kestler, J. S. Foster, K. D. Gray, A. Solomon and J. L. Bell, "Odontogenic Ameloblast ...
more infohttps://www.scirp.org/Journal/PaperInformation.aspx?PaperID=37036

Paper: Expression of FAM20A, causative gene for Amelogenesis Imperfecta in ameloblasts (AADR Annual Meeting (March 21-24, 2012))Paper: Expression of FAM20A, causative gene for Amelogenesis Imperfecta in ameloblasts (AADR Annual Meeting (March 21-24, 2012))

Keywords: Ameloblasts, Amelogenesis Imperfecta, Gene expression and Teeth See more of: Genetics and Epigenetics of Craniofacial ... 1561 Expression of FAM20A, causative gene for Amelogenesis Imperfecta in ameloblasts Saturday, March 24, 2012: 9:45 a.m. - 11 a ... The expression was also confirmed in the LS8 ameloblast cell line. The IP-WB analysis was performed using cultured media and ... Conclusion: We demonstrated the intracellular expression of FAM20A in LS8 ameloblasts. Our data suggest that FAM20A is a novel ...
more infohttp://www-personal.umich.edu/~sbayne/DMG/DMG-Publications/IADR-AADR-Meeting-Program-Books/2012-AADR-Tampa/2012-AADR-Tampa-CD/AADR12/Paper158375.html

Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-AldrichComparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-Aldrich

Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression.. [Juni Sarkar, Emil J Simanian, Sarah Y ... Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The ... In this study we compare the expression profiles of enamel-specific genes in two mouse derived ameloblast-like cell lines: LS8 ...
more infohttps://www.sigmaaldrich.com/catalog/papers/25120490

Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium - Nishio - 2013 -...Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium - Nishio - 2013 -...

Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium. Authors. *. Clarice Nishio, ... Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ... the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these ... ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, ...
more infohttp://onlinelibrary.wiley.com/doi/10.1111/prd.12031/abstract

The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation | DevelopmentThe Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation | Development

This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ... The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation ...
more infohttp://dev.biologists.org/content/140/16/3348.short

JCI Insight -
Store-operated Ca2+ entry controls ameloblast cell function and enamel developmentJCI Insight - Store-operated Ca2+ entry controls ameloblast cell function and enamel development

The morphology of SOCE-deficient ameloblasts was altered, showing loss of the typical ruffled border, resulting in mislocalized ... Global gene expression analysis of SOCE-deficient ameloblasts revealed strong dysregulation of several pathways. ER stress ... Store-operated Ca2+ entry controls ameloblast cell function and enamel development. ... Store-operated Ca2+ entry controls ameloblast cell function and enamel development. ...
more infohttps://insight.jci.org/articles/view/91166/pdf

Int J Dev Biol - Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review.Int J Dev Biol - Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review.

... which supports the theory that ameloblasts and odontoblasts are target-cells for 1,25 is presented. As a perspective, a cross- ... Ameloblasts and odontoblasts, target-cells for 1,25-dihydroxyvitamin D3: a review.. A Berdal, P Papagerakis, D Hotton, I ... which supports the theory that ameloblasts and odontoblasts are target-cells for 1,25 is presented. As a perspective, a cross- ...
more infohttp://www.ijdb.ehu.es/web/paper/7626415/ameloblasts-and-odontoblasts-target-cells-for-125-dihydroxyvitamin-d3-a-review

KAKEN - Research Projects | Possible Roles of Shh in Ameloblast differentiation (KAKENHI-PROJECT-15591927)KAKEN - Research Projects | Possible Roles of Shh in Ameloblast differentiation (KAKENHI-PROJECT-15591927)

Journal Article] Characteristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts. *. Author(s ... Journal Article] Characteristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts2005. *. ... Journal Article] Characterristic distribution of immunoreaction for estrogen receptor alpha(ERα) in rat ameloblasts2005. *. ... Immunoreation became weak in the ameloblasts towards cervical regions. Furthermore, Shh-immunoreation was distributed in the ...
more infohttps://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591927/

Plus itPlus it

Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ... Abstract 92: Odonogenic Ameloblast Associated Protein (ODAM) moderates cell growth and invasion in the human breast cancer line ...
more infohttp://cancerres.aacrjournals.org/content/72/8_Supplement/92

A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination  -...A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination -...

A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination ZORA ... Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with ... Tbx1 expression is restricted to epithelial cells that give rise to the enamel producing ameloblasts and correlates with ... Download PDF A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage ...
more infohttps://www.zora.uzh.ch/id/eprint/9217/

Efficient induction of functional ameloblasts from human keratinocyte stem cells | Stem Cell Research & Therapy | Full TextEfficient induction of functional ameloblasts from human keratinocyte stem cells | Stem Cell Research & Therapy | Full Text

Although adult human tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and ... and well-differentiated ameloblasts (am) at day 9 (E), respectively, after subrenal culture. F hKSC-derived ameloblasts began ... Induction of human keratinocytes into enamel-secreting ameloblasts. Dev Biol. 2010;344:795.View ArticlePubMedPubMed Central ... Bei M, Stowell S, Maas R. Msx2 controls ameloblast terminal differentiation. Dev Dyn. 2004;231(4):758-65.View ArticlePubMed ...
more infohttps://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0822-4

Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional...Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional...

... odontogenic ameloblast-associated (ODAM) and amelotin (AMTN), have been identified in the JE. The objective of this study was ... Expression pattern of odontogenic ameloblast-associated and amelotin during formation and regeneration of the junctional ... Localization and expression pattern of amelotin, odontogenic ameloblast-associated protein and follicular dendritic cell- ... article{Nishio2010ExpressionPO, title={Expression pattern of odontogenic ameloblast-associated and amelotin during formation ...
more infohttps://www.semanticscholar.org/paper/Expression-pattern-of-odontogenic-ameloblast-assoc-Nishio-Wazen/9c7ba667ee6388036971fafcd4eb5510c111c099

E-GEOD-63289 - Transcriptome of human odontoblast, pre-secretory ameloblast and secretory ameloblast - OmicsDIE-GEOD-63289 - Transcriptome of human odontoblast, pre-secretory ameloblast and secretory ameloblast - OmicsDI

In total, 4 odontoblast, 4 pre-secretory ameloblast and 4 secretory ameloblast pooled samples were used for RNA extraction and ... presecretory ameloblasts 15,179 genes and secretory ameloblasts 14,526 genes. Four human fetuses were obtained at ages 15-20 ... These sections were used for laser capture microdissection (LCM) to isolate the human odontoblasts and ameloblasts in different ... The goal of the study was to characterize the whole genome transcriptome profiles of human ameloblasts and odontoblasts, ...
more infohttps://www.omicsdi.org/dataset/arrayexpress-repository/E-GEOD-63289

BDPI USP - Detalhe do registro: Expression of connexin 43 and ZO-1 differentiating ameloblasts and odontoblasts from rat molar...BDPI USP - Detalhe do registro: Expression of connexin 43 and ZO-1 differentiating ameloblasts and odontoblasts from rat molar...

Ultrastructure of ameloblasts and immunolocatization of amelogenin in the enamel-free area of rat molars ... Ultrastructure of ameloblasts and immunolocalization of amelogenin in the enamel-free area of rat molars ... Expression of connexin 43 and ZO-1 differentiating ameloblasts and odontoblasts from rat molar tooth germs (2003). *Authors: * ... João, S. M. A., & Arana Chavez, V. E. (2003). Expression of connexin 43 and ZO-1 differentiating ameloblasts and odontoblasts ...
more infohttps://bdpi.usp.br/item/001307814

YUHSpace: Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB...YUHSpace: Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB...

... is implicated in ameloblast differentiation, doi: 10.1002/jcb.24047, category: Article ... Odontogenic ameloblasts-associated protein (ODAM), via phosphorylation by bone morphogenetic protein receptor type IB (BMPR-IB ... To elucidate the function of the odontogenic ameloblast-associated protein (ODAM) in ameloblasts, we identified more than 74 ... ODAM phosphorylation was detected in ameloblasts during ameloblast differentiation and enamel mineralization in vitro and ...
more infohttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90668
  • An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. (pnas.org)
  • 45 Ca autoradiography studies have shown that at least calcium ions can pass through the intercellular space of secretory ameloblasts and SAs in a short time, but that these ions pass through the RA layer more slowly ( Kawamoto and Shimizu, 1997 ). (frontiersin.org)
  • In total of 3 pre-ameloblasts and 3 secretory ameloblasts pooled samples were used for RNA extraction and hybridization on Affymetrix microarray. (omicsdi.org)
  • It is theorized that a circadian clock (24-hour) probably regulates enamel production on a daily cycle by the ameloblasts (similar to osteoblasts in production of bone tissue). (wikipedia.org)
  • An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. (pnas.org)
  • Maturation ameloblasts undergo several modulation cycles, involving two different types of cell morphology, during enamel maturation ( Josephsen and Fejerskov, 1977 ). (frontiersin.org)
  • The morphology of SOCE-deficient ameloblasts was altered, showing loss of the typical ruffled border, resulting in mislocalized mitochondria. (jci.org)
  • Consistent with increased oxidative stress, we found increased ROS production, decreased mitochondrial function, and abnormal mitochondrial morphology in ameloblasts of Stim1/2 K14cre mice. (jci.org)
  • Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the tooth forming the surface of the crown. (wikipedia.org)
  • Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross section. (wikipedia.org)
  • Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy. (frontiersin.org)
  • In this study, the localization of claudin-1 in maturation ameloblasts was examined using immunofluorescence microscopy. (frontiersin.org)
  • Immunoreation became weak in the ameloblasts towards cervical regions. (nii.ac.jp)
  • Moreover, modulation cycles involve the rapid movement of wave-like bands of RA and SA over the ameloblast layer, that are a result of extensive RA-to-SA or SA-to-RA changes during maturation. (frontiersin.org)
  • These two types of ameloblasts are referred to as ruffle-ended ameloblasts (RA) and smooth-ended ameloblasts (SA), respectively. (frontiersin.org)