AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
AmeloblastsAmelogenesisEnamel OrganDental Enamel ProteinsDental EnamelIncisorAmelogeninTooth CalcificationOdontogenesisToothTooth GermOdontoblastsMolarDental Enamel HypoplasiaAmelogenesis ImperfectaMatrix Metalloproteinase 20Fluorosis, DentalSLC4A ProteinsTooth AbnormalitiesPlastic EmbeddingDentinDentinogenesisTooth CrownDental PulpSodium FluorideClaudin-1FluoridesMandibleAnion Transport ProteinsProton PumpsAntiportersSodium-Bicarbonate Symporters
Ameloblasts
Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)
Amelogenesis
The elaboration of dental enamel by ameloblasts, beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (Jablonski, Dictionary of Dentistry, 1992).
Enamel Organ
Epithelial cells surrounding the dental papilla and differentiated into three layers: the inner enamel epithelium, consisting of ameloblasts which eventually form the enamel, and the enamel pulp and external enamel epithelium, both of which atrophy and disappear before and upon eruption of the tooth, respectively.
Dental Enamel Proteins
The proteins that are part of the dental enamel matrix.
Dental Enamel
A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)
Incisor
Any of the eight frontal teeth (four maxillary and four mandibular) having a sharp incisal edge for cutting food and a single root, which occurs in man both as a deciduous and a permanent tooth. (Jablonski, Dictionary of Dentistry, 1992, p820)
Amelogenin
A major dental enamel-forming protein found in mammals. In humans the protein is encoded by GENES found on both the X CHROMOSOME and the Y CHROMOSOME.
Tooth Calcification
The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)
Odontogenesis
The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).
Tooth
One of a set of bone-like structures in the mouth used for biting and chewing.
Tooth Germ
The collective tissues from which an entire tooth is formed, including the DENTAL SAC; ENAMEL ORGAN; and DENTAL PAPILLA. (From Jablonski, Dictionary of Dentistry, 1992)
Odontoblasts
Molar
The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)
Dental Enamel Hypoplasia
An acquired or hereditary condition due to deficiency in the formation of tooth enamel (AMELOGENESIS). It is usually characterized by defective, thin, or malformed DENTAL ENAMEL. Risk factors for enamel hypoplasia include gene mutations, nutritional deficiencies, diseases, and environmental factors.
Amelogenesis Imperfecta
A clinically and genetically heterogeneous group of hereditary conditions characterized by malformed DENTAL ENAMEL, usually involving DENTAL ENAMEL HYPOPLASIA and/or TOOTH HYPOMINERALIZATION.
Matrix Metalloproteinase 20
A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matrix. The enzyme has a high specificity for dental enamel matrix protein AMELOGENIN.
Fluorosis, Dental
A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)
SLC4A Proteins
Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).
Tooth Abnormalities
Congenital absence of or defects in structures of the teeth.
Plastic Embedding
The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.
Dentin
The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)
Dentinogenesis
The formation of dentin. Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. Formation progresses from the tip of the papilla over its slope to form a calcified cap becoming thicker by the apposition of new layers pulpward. A layer of uncalcified dentin intervenes between the calcified tissue and the odontoblast and its processes. (From Jablonski, Dictionary of Dentistry, 1992)
Tooth Crown
The upper part of the tooth, which joins the lower part of the tooth (TOOTH ROOT) at the cervix (TOOTH CERVIX) at a line called the cementoenamel junction. The entire surface of the crown is covered with enamel which is thicker at the extremity and becomes progressively thinner toward the cervix. (From Jablonski, Dictionary of Dentistry, 1992, p216)
Dental Pulp
A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)
Sodium Fluoride
A source of inorganic fluoride which is used topically to prevent dental caries.
Claudin-1
An integral membrane protein that is localized to TIGHT JUNCTIONS, where it plays a role in controlling the paracellular permeability of polarized cells. Mutations in the gene for claudin-1 are associated with Neonatal Ichthyosis-Sclerosing Cholangitis (NISCH) Syndrome.
Fluorides
Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.
Mandible
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
Anion Transport Proteins
Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.
Proton Pumps
Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.
Antiporters
Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.
Sodium-Bicarbonate Symporters
Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.

Scanning electron microscopy of the lateral cell surfaces of rat incisor ameloblasts. (1/196)

Dry dissected rat incisor ameloblasts studied in the scanning electron microscope show remarkable specializations of their lateral surfaces. Four or five cycles of a change from a surface with longitudinal gutterlike folds associated with large intercellular spaces, to one with microvilli and reduced intercellular spaces, are found along the length of the lower incisor maturation zone. It is argued that these changes indicate cyclical activity in maturation ameloblasts.  (+info)

Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. (2/196)

Laminin 5 regulates anchorage and motility of epithelial cells through integrins alpha6beta4 and alpha3beta1, respectively. We used targeted disruption of the LAMA3 gene, which encodes the alpha3 subunit of laminin 5 and other isoforms, to examine developmental functions that are regulated by adhesion to the basement membrane (BM). In homozygous null animals, profound epithelial abnormalities were detected that resulted in neonatal lethality, consistent with removal of all alpha3-laminin isoforms from epithelial BMs. Alterations in three different cellular functions were identified. First, using a novel tissue adhesion assay, we found that the mutant BM could not induce stable adhesion by integrin alpha6beta4, consistent with the presence of junctional blisters and abnormal hemidesmosomes. In the absence of laminin 5 function, we were able to detect a new ligand for integrin alpha3beta1 in the epidermal BM, suggesting that basal keratinocytes can utilize integrin alpha3beta1 to interact with an alternative ligand. Second, we identified a survival defect in mutant epithelial cells that could be rescued by exogenous laminin 5, collagen, or an antibody against integrin alpha6beta4, suggesting that signaling through beta1 or beta4 integrins is sufficient for survival. Third, we detected abnormalities in ameloblast differentiation in developing mutant incisors indicating that events downstream of adhesion are affected in mutant animals. These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium.  (+info)

Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. (3/196)

About 80% of all cases of Fanconi anemia (FA) can be accounted for by complementation groups A and C. To understand the relationship between these groups, we analyzed the expression pattern of the mouse FA group-A gene (Fanca) during embryogenesis and compared it with the known pattern of the group-C gene (Fancc). Northern analysis of RNA from mouse embryos at embryonic days 7, 11, 15, and 17 showed a predominant 4.5 kb band in all stages. By in situ hybridization, Fanca transcripts were found in the whisker follicles, teeth, brain, retina, kidney, liver, and limbs. There was also stage-specific variation in Fanca expression, particularly within the developing whiskers and the brain. Some tissues known to express Fancc (eg, gut) failed to show Fanca expression. These observations show that (1) Fanca is under both tissue- and stage-specific regulation in several tissues; (2) the expression pattern of Fanca is consistent with the phenotype of the human disease; and (3) Fanca expression is not necessarily coupled to that of Fancc. The presence of distinct tissue targets for FA genes suggests that some of the variability in the clinical phenotype can be attributed to the complementation group assignment.  (+info)

Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. (4/196)

The continuously growing mouse incisor is an excellent model to analyze the mechanisms for stem cell lineage. We designed an organ culture method for the apical end of the incisor and analyzed the epithelial cell lineage by 5-bromo-2'-deoxyuridine and DiI labeling. Our results indicate that stem cells reside in the cervical loop epithelium consisting of a central core of stellate reticulum cells surrounded by a layer of basal epithelial cells, and that they give rise to transit-amplifying progeny differentiating into enamel forming ameloblasts. We identified slowly dividing cells among the Notch1-expressing stellate reticulum cells in specific locations near the basal epithelial cells expressing lunatic fringe, a secretory molecule modulating Notch signaling. It is known from tissue recombination studies that in the mouse incisor the mesenchyme regulates the continuous growth of epithelium. Expression of Fgf-3 and Fgf-10 were restricted to the mesenchyme underlying the basal epithelial cells and the transit-amplifying cells expressing their receptors Fgfr1b and Fgfr2b. When FGF-10 protein was applied with beads on the cultured cervical loop epithelium it stimulated cell proliferation as well as expression of lunatic fringe. We present a model in which FGF signaling from the mesenchyme regulates the Notch pathway in dental epithelial stem cells via stimulation of lunatic fringe expression and, thereby, has a central role in coupling the mitogenesis and fate decision of stem cells.  (+info)

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts. (5/196)

Dentin sialoprotein and dentin phosphoprotein are non-collagenous proteins that are cleavage products of dentin sialophosphoprotein (DSPP). Although these two protein products are believed to have a crucial role in the process of tooth mineralization, their precise biological functions and the molecular mechanisms of gene regulation are not clearly understood. To understand such functions, we have developed a transgenic mouse model expressing a reporter gene (lacZ) under the control of approximately 6 kb upstream sequences of Dspp. The transgenic fusion protein was designed to reside within the cells to facilitate the precise identification of cell type and developmental stages at which the Dspp-lacZ gene is expressed. The results presented in this report demonstrate: (a) the 6 kb upstream sequences of Dspp have the necessary regulatory elements to direct the tissue specific expression of the transgene similar to endogenous Dspp, (b) both odontoblasts and ameloblasts exhibit transgene expression in a differentiation dependent manner, and (c) a differential regulation of the transgene in odontoblasts and ameloblasts occurs during tooth development and mineralization.  (+info)

Subtilisin-like proprotein convertase PACE4 (SPC4) is a candidate processing enzyme of bone morphogenetic proteins during tooth formation. (6/196)

The temporospatial expression of PACE4, a member of the mammalian subtilisin-like proprotein convertase family, in the developing rat molar tooth was determined by in situ hybridization. At the initiation stage of tooth development, PACE4 mRNA was weakly expressed in the dental lamina, whereas the mesenchymal cells intensely expressed the PACE4 transcript. At the bud stage, high-level expression of PACE4 mRNA was found in the dental epithelium and condensed dental mesenchyme. Its expression became more localized in the differentiating ameloblasts during cap and early bell stages. In the newborn rats, PACE4 mRNA was localized in the ameloblasts and odontoblasts, but its expression became weaker with advancing development, showing apparent association with the differentiation and establishment of functional ameloblasts and odontoblasts. These expression patterns of PACE4 were very similar to those of several bone morphogenetic proteins (BMPs) reported previously. Because BMPs, which are primarily involved in the morphogenesis in tooth formation, are synthesized as inactive precursors and activated by limited proteolysis at the consensus Arg-X-X-Arg maturation site, the present observations suggest that PACE4 is possibly a candidate proBMP convertase that acts during tooth formation.  (+info)

Transcription factor Sp3 is essential for post-natal survival and late tooth development. (7/196)

Sp3 is a ubiquitously expressed transcription factor closely related to Sp1 (specificity protein 1). We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histological examinations of individual organs in Sp3(-/-) mice show a pronounced defect in late tooth formation. In Sp3 null mice, the dentin/enamel layer of the developing teeth is impaired due to the lack of ameloblast-specific gene products. Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy.  (+info)

Calbindin D28k-like immunoreactivity during the formation of the enamel-free area in the rat molar teeth. (8/196)

Previous studies have demonstrated the presence of calbindin D28k in the ameloblasts derived from the inner enamel epithelium. The occlusal surfaces of the rodent molars partly lack the enamel covering, which is referred to as enamel-free area (EFA). In the present study, we compared the immunohistochemical localization of calbindin D28k-like immunoreactivity (CB-LI) in the cells at the EFA (EFA cells) and ameloblasts of the rat molar teeth at the light microscopic level. CB-LI was strong in the ameloblasts of the presecretory through the protective stages, while it was faint at the late secretory to transitional stages. However, some mature ameloblasts lacked the immunoreactivity. On the other hand, the majority of EFA cells showed distinct polarization and elongation that were absent in few cells at the early stage of EFA formation. At all stages, the EFA cells adjacent to the ameloblasts showed CB-LI, however, some cells adjacent to the mature ameloblasts lacked the reaction. Intensive CB-LI was demonstrated in EFA cells at the reduced enamel epithelium. These immunohistochemical findings suggest EFA cells have cytochemical properties similar to those of ameloblasts.  (+info)

HKU Scholars Hub: Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralizationHKU Scholars Hub: Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization
Enamel is the hardest tissue with the highest degree of mineralization protecting the dental pulp from injury in vertebrates. The ameloblasts differentiated from ectoderm-derived epithelial cells are a single cell layer and are important for the enamel formation and mineralization. Wnt/β-catenin signaling has been proven to exert an important role in the mineralization of bone, dentin and cementum. Little was known about the regulatory mechanism of Wnt/β-catenin signaling pathway in ameloblasts during amelogenesis, especially in the mineralization of enamel. To investigate the role of β-catenin in ameloblasts, we established Amelx-Cre; β-catenin∆ex3fl/fl (CA-β-catenin) mice, which could constitutive activate β-catenin in ameloblasts. It showed the delayed mineralization and eventual hypomineralization in the incisor enamel of CA-β-catenin mice. Meanwhile, the amelogenesis-related proteinases Mmp20 and Klk4 were decreased in the incisors of CA-β-catenin mice. These data indicated that ...
https://hub.hku.hk/handle/10722/279122
Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNASCtip2/Bcl11b controls ameloblast formation during mammalian odontogenesis | PNAS
The transcription factor Ctip2/Bcl11b plays essential roles in developmental processes of the immune and central nervous systems and skin. Here we show that Ctip2 also plays a key role in tooth development. Ctip2 is highly expressed in the ectodermal components of the developing tooth, including inner and outer enamel epithelia, stellate reticulum, stratum intermedium, and the ameloblast cell lineage. In Ctip2−/− mice, tooth morphogenesis appeared to proceed normally through the cap stage but developed multiple defects at the bell stage. Mutant incisors and molars were reduced in size and exhibited hypoplasticity of the stellate reticulum. An ameloblast-like cell population developed ectopically on the lingual aspect of mutant lower incisors, and the morphology, polarization, and adhesion properties of ameloblasts on the labial side of these teeth were severely disrupted. Perturbations of gene expression were also observed in the mandible of Ctip2−/− mice: expression of the ameloblast ...
https://www.pnas.org/content/early/2009/02/25/0900568106.abstract
Early Ameloblasts Development in the Dental Enamel - LifeMap DiscoveryEarly Ameloblasts Development in the Dental Enamel - LifeMap Discovery
Cells of the inner enamel epithelium located adjacent to the dental papilla mesenchymal cells, differentiate into early ameloblasts during the bell stage. Early ameloblasts differentiate into mature cells through pre-secretory and secretory stages. During the pre-secretory stage, the early ameloblasts differentiate and initiate synthesis of the enamel-related proteins. In the secretory stage, the matrix proteins accumulate extracellularly and the tooth crown is formed ...
https://discovery.lifemapsc.com/in-vivo-development/tooth/dental-enamel/early-ameloblasts
Quintessence PublishingQuintessence Publishing
Objective: To observe the effect of fluoride overdose on the proliferation of the pure Wistar rats incisor ameloblasts. Material and Methods: Twenty healthy Wistar rats were randomly divided into 2 groups, Group I (the control) and Group II (receiving 50 mg/L F-). After 8 weeks treatment the AgNORs stain and TUNEL technique were used to analyze the effect of fluoride on the proliferation and apoptosis of ameloblasts. Results: Incremental lines in the incisors in Group II were clearly visible and eosinophilic granules had accumulated in the ameloblasts in the secretory stage. The number of AgNORs granules in the ameloblasts in the pre-secretory stage in Group II was lower than in Group I, and the difference was statistically relevant (p < 0.001); more ameloblasts experienced apoptosis or migrated in the secretory stage. Conclusion: Fluoride overdose can inhibit proliferation of the ameloblasts and accelerate their apoptosis, which is what is meant by fluorosis. ...
http://www.quintpub.com/journals/cjdr/archive_display_abstract.php3?journalArt=6082
Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-AldrichComparison of two mouse ameloblast-like cell lines for enamel-specific gene expression. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Juni Sarkar, Emil J Simanian, Sarah Y Tuggy, John D Bartlett, Malcolm L Snead, Toshihiro Sugiyama, Michael L Paine].
https://www.sigmaaldrich.com/catalog/papers/25120490
Scientists uncover secret to sharp teeth | EurekAlert! Science NewsScientists uncover secret to sharp teeth | EurekAlert! Science News
Researchers identify a molecular mechanism that controls the precise patterning of enamel formation on incisor teeth. Mouse incisors are covered with enamel on the side closest to the lip while the other side remains enamel-free. This irregular distribution of enamel helps keep the cutting edges of the incisors very sharp. While it is well established that ameloblasts secrete enamel, the molecular signals regulating asymmetric ameloblast differentiation from the underlying dental epithelium are not well understood.
https://www.eurekalert.org/pub_releases/2004-11/cp-sus110204.php
New connections: Protein trafficking for strong bones and teeth | Science SignalingNew connections: Protein trafficking for strong bones and teeth | Science Signaling
The bone matrix and tooth enamel are the hardest substances in the body, and both are formed through the mineralization of proteins secreted by osteoblasts and ameloblasts, respectively. One of the primary components of the bone matrix is collagen, which provides strength, as well as acts as a substrate for mineralization. Amelogenin is the main extracellular matrix protein secreted by ameloblasts and is important for both the inclusion of minerals and the proper structure of tooth enamel. Defects in the secretion or structure of these extracellular matrices compromise the strength and durability of the tissues. Two studies reveal distinct mechanisms of secretory dysregulation that affect proper mineralization of these tissues. Zhao et al. found that the trimeric intracellular cation channel Tric-b, which localizes to the endoplasmic reticulum (ER), was important to secretion of collagen by osteoblasts in mice. Mutations in TMEM38b, the human homolog of Tric-b, are associated with osteogenesis ...
http://stke.sciencemag.org/content/10/465/eaam8579.full
Alan Brymer on How To Run a Successful Real Estate Business Monday, August 4, 2008Alan Brymer on How To Run a Successful Real Estate Business Monday, August 4, 2008
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https://www.voiceamerica.com/episode/31525/alan-brymer-on-how-to-run-a-successful-real-estate-business
Incisor - wikidocIncisor - wikidoc
The rodent incisor is one of the evolutionary adaptations that make rodents such a successful group. There are two incisors in the upper jaw and two in the lower jaw. The incisors are separated from the molars by a diastema region, an area without any teeth. The tissue of the incisor is regenerated from the apical end and constantly wears down at the distal tip. The ever-growing incisor can be subdivided into two areas, the crown analogue and the root analogue. The crown analogue is the labial half of the incisor. It is characterized by an enlarged cervical loop at the apical end. The cervical loop is the epithelial stem cell niche. The epithelial progeny of the crown analogues cervical loop differentiates into ameloblasts that produce enamel. The root analogue is the lingual half of the incisor. Its cervical loop is much smaller and the epithelium does not differentiate into ameloblasts, but instead forms a root sheath and fragments into epithelial cell rests of Malassez typical of root ...
https://wikidoc.org/index.php/Upper_incisors
Gene expression in tooth: references
The effect of a 2 hour exposure to adriamycin (1 mg/litre) on alkaline phosphatase (ALPase) activity of the golden hamster 4-5 day old second maxillary molars (M2) was investigated in vitro. The molars were grown in BGJb medium containing 15% fetal bovine serum, glutamine (200 micrograms/ml), vitamin C (250 micrograms/ml), penicillin G (50 micrograms/ml), and streptomycin sulphate (30 micrograms/ml). The gas phase contained 50% O2 + 5% CO2 + 45% N2. The molars were supported on cellulosic membrane filters and grown for 3, 5, and 7 days at the medium-gas interface in a closed humidified chamber. Biochemical analysis indicated a steady increase in ALPase activity throughout this study in the control samples. However, after adriamycin treatment no increase in ALPase activity could be observed. The histochemical data showed that the increased activity in the control was confined to the peripheral pulp, sub-odontoblastic layer, stratum intermedium, ameloblasts and odontoblasts. Although these layers ...
http://bite-it.helsinki.fi/REF179.HTM
The Bouletcorp » Rise of the GeeksThe Bouletcorp » Rise of the Geeks
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http://english.bouletcorp.com/2007/11/08/rise-of-the-geeks/
Fuck Peter PanFuck Peter Pan
For my french work, I drew a lot of books, here the entire list:. Glénat Editions:. -Raghnarok. Tome 1 : Dragon Junior. Tome 2 : Fées et Gestes. Tome 3 : Terreurs de la nature. Tome 4 : Légendes urbaines. Tome 5 : Tempus Fugit. Tome 6 : Casus Belli. -La Rubrique Scientifique. Tome 1. Tome 2. Tome 3. -Le Miya (with Reno, Julien Néel and Libon). -Womoks (only scenario, drawing by Reno). Tome 1 : Mutant, suspends ton vol…. Tome 2 : Le croiseur samuse. Tome 3 : Albon, les brutes et les truands. La boîte à bulles Edition:. -Le vœu de…. Tome 1 : Le vœu de Marc (coscenarist with Nicolas Wild, drawing by Lucie Albon). Tome 2 : Le vœu de Simon (coscenarist with Lucie Albon, drawing by Lucie Albon). -Amour et Désir (Collectif, seven pages under the alias Ella Forbin). -Delcourt Edition:. -Donjon (avec Lewis Trondheim et Joann Sfar au scénario, et Lucie Albon à la couleur). Tome 5 : Un mariage à part. Tome 6 : Retour en fanfare. -Notes (these are the compilations of all the entries of ...
http://english.bouletcorp.com/2007/12/11/fuck-peter-pan/
Plus itPlus it
Breast neoplasms are the second leading cause of cancer deaths of women in the United States. Recently, it has been shown by immunohistochemical staining of tumor biopsy tissue that nuclear localization of the odontogenic ameloblast associated protein (ODAM) correlated with staging and increased survival in patients, leading to the proposal of this protein as a novel biomarker in breast cancer. Further, ectopic expression of recombinant ODAM protein in the invasive breast carcinoma line MDA-MB-231 (231-ODAM) was shown to slow cell growth to 30-50% of that seen in control 231 cells, increase apoptosis, effect developmental change, and decrease the ability of cells to migrate or invade through extracellular matrix in transwell barrier assays. Further, this expression reduced the ability of these cells to form solid tumors by greater than 10-fold in immunodeficient mice, or establish tumor colonization of the lungs after tail vein injection. Herein, we show results of microarray and qRT-PCR data ...
http://cancerres.aacrjournals.org/content/72/8_Supplement/92
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NJEGA LICA : Hydratonic serumNJEGA LICA : Hydratonic serum
3u1 Krema za uklanjanje make-upa, čišćenje i njegu lica Bogata, prirodna, hidratantna formula omogućuje učinkovito uklanjanje makeupa te čšćenje lica bez iritacija i crvenila, a pri tome njeguje kožu i osigurava joj potrebnu vlagu. Nanosi se direktno na kožu ili na blazinicu. Ne treba se ispirati.
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Organic Eprints - Increased production and closer relationships between organic and inherent qualities of organic foodOrganic Eprints - Increased production and closer relationships between organic and inherent qualities of organic food
The remit of DARCOF II is to produce knowledge that can support increased production and a closer relationship between the inherent and organic qualities of organic foods. The objectives are to provide information on ...
https://orgprints.org/id/eprint/5345/
Tooth enamel formation, SEM - Stock Image P486/0080 - Science Photo LibraryTooth enamel formation, SEM - Stock Image P486/0080 - Science Photo Library
Tooth enamel formation. Coloured scanning electron micrograph (SEM) of a freeze-fractured section through a tooth, showing the enamel-forming cell layer (green). This epithelium comprises a single layer of columnar cells called ameloblasts. The fracture plane passes up into the tooth from the enamel surface (orange, bottom left). The ameloblast layer has detached from the enamel in which it is normally embedded. Enamel is a hard ceramic layer that covers and protects the teeth. The other end of the ameloblasts originate in the internal tooth tissue (brown, across top). Magnification unknown. - Stock Image P486/0080
http://www.sciencephoto.com/media/309535/view
Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium - Nishio - 2013 -...Expression of odontogenic ameloblast-associated and amelotin proteins in the junctional epithelium - Nishio - 2013 -...
Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these proteins in the formation and regeneration of the junctional epithelium. ...
http://onlinelibrary.wiley.com/doi/10.1111/prd.12031/abstract
Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFβ1 in mouse gingival...
TY - JOUR. T1 - Amelotin gene expression is temporarily being upregulated at the initiation of apoptosis induced by TGFβ1 in mouse gingival epithelial cells. AU - Nakayama, Yohei. AU - Matsui, Sari. AU - Noda, Keisuke. AU - Yamazaki, Mizuho. AU - Iwai, Yasunobu. AU - Matsumura, Hiroyoshi. AU - Izawa, Takashi. AU - Tanaka, Eiji. AU - Ganss, Bernhard. AU - Ogata, Yorimasa. PY - 2016/10/1. Y1 - 2016/10/1. N2 - Amelotin (AMTN) is expressed and secreted by ameloblasts in the maturation stage of amelogenesis and persist with low levels in the junctional epithelium (JE) of erupted teeth. The purpose of this study is to investigate the transcriptional regulation of the AMTN gene by transforming growth factor beta1 (TGFβ1) in gingival epithelial (GE1) cells in the apoptosis phase. Apoptosis was evaluated by the fragmentation of chromosomal DNA and TUNEL staining. A real-time PCR was carried out to examine the AMTN mRNA levels induced by TGFβ1 and Smad3 overexpression. Transient transfection analyses ...
https://okayama.pure.elsevier.com/en/publications/amelotin-gene-expression-is-temporarily-being-upregulated-at-the-
Sao Tome And Principe 30 Days Tourist VisaSao Tome And Principe 30 Days Tourist Visa
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Dampierre - Tome 03 eBook by Yves Swolfs - 9782331014192 | Rakuten KoboDampierre - Tome 03 eBook by Yves Swolfs - 9782331014192 | Rakuten Kobo
Read Dampierre - Tome 03 Les Emissaires by Yves Swolfs with Rakuten Kobo. Alors que la Révolution triomphe à Paris, en Vendée le peuple résiste aux idéaux révolutionnaires qui bafouent coutume...
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Sequence DetailSequence Detail
cdna chromosome:GRCm38:5:88456011:88468531:1 gene:ENSMUSG00000029288 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Ambn description:ameloblastin [Source:MGI Symbol;Acc:MGI:104655 ...
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Ahead of the Wave: TomesAhead of the Wave: Tomes
I dont! I have been lugging a copy of Anna Karenina around with me for ages (in fact, I have it here in my office with me now), and according to a dog-eared page, I am on p. 271. The problem? At this point I have not a damn clue what is going on. Who the heck is Sergey Ivanovich Koznyshev? I have no clue whatsoever. Do I start over? I started this book before law school, so I am averaging about 50 pages per year.. ReplyDelete ...
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Integrative analysis of gene expression and phenotype data :: University of Southern California Dissertations and Theses
Dental enamel is the hardest mineralized tissue in the body and initially forms from a protein matrix. During enamel formation, ameloblasts secrete unique proteins into the extracellular space to direct mineralization of enamel crystallites. This specialized organic matrix contains the proteins amelogenin, ameloblastin, and enamelin. Amelogenin is the major enamel matrix protein secreted, comprising ~95% of the total matrix, yet after maturation and completion of amelogenesis, only ~1% of the initial organic matrix remains in mineralized enamel. Ameloblasts, being the only cells in close proximity to the organic matrix, most likely are responsible for the removal of proteinaceous matrix debris for proper enamel maturation. The rapid removal of enamel matrix proteins is poorly understood in the literature, principally because clathrin (the prototypical pathway for endocytosis) is expressed at very low levels in ameloblasts. Most of the historical record of endocytosis is focused on clathrin ...
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/406502/rec/2
Epiprofin/Sp6: A new player in the regulation of tooth development - InfoscienceEpiprofin/Sp6: A new player in the regulation of tooth development - Infoscience
Odontogenesis is governed by a complex network of intercellular signaling events between the dental epithelium and mesenchyme. This network leads to the progressive determination of tooth shape, and to the differentiation of these tissues into enamel-producing ameloblasts and dentin-producing odontoblasts respectively. Among the main signaling pathways involved in the regulation of tooth development, Bone Morphogenetic Protein (BMP), Sonic hedgehog (Shh) and Wingless-type MMTV integration site (Wnt) pathways have been reported to play significant roles. Recently, the phenotype of mice deficient in Epiprofin/Sp6 (Epfn) has been found to present striking dental abnormalities, including a complete lack of differentiated ameloblasts and consequently no enamel, highly altered molar cusp patterns and the formation of multiple supernumerary teeth. In this article, we review the interaction of Epfn with the BMP, Shh and Wnt pathways in the regulation of tooth development, based on the data obtained from the
https://infoscience.epfl.ch/record/172330
Gene expression in tooth: references
We have studied the expression of transforming growth factor beta-1 (TGF-beta 1) RNA during mouse tooth development, using in situ hybridization and experimental tissue recombinations. Analysis of the serial sections revealed the appearance of local expression of TGF-beta 1 RNA in the dental epithelium at bud- staged teeth (13-day embryos). Just before transition to the cap stage, TGF-beta 1 RNA expression rapidly increased in the epithelial bud, and it also extended to the condensed dental mesenchyme. At cap stage (14- and 15-day embryos), there was an intense expression of TGF-beta 1 RNA in the morphologically active cervical loops of the dental epithelium. During early bell stage (16- and 17-day embryos), TGF-beta 1 RNA expression was detected in the inner enamel epithelium where it subsequently almost disappeared (18- day embryos). After birth TGF-beta 1 transcripts transiently appeared in these cells when they were differentiating into ameloblasts (1-day mice). The transcripts were lost ...
http://bite-it.helsinki.fi/REF6.HTM
BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor | Nature Cell BiologyBMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor | Nature Cell Biology
The polycomb protein BMI1 has been linked to maintenance of adult stem cells. Klein and colleagues find that BMI1 is also required for the maintenance of stem cells in the continuously growing mouse incisor, through repression of the Ink4a/Arf locus to modulate the proliferation of stem cells and repression of Hox genes to prevent inappropriate lineage decisions in stem cell progeny. The polycomb group gene Bmi1 is required for maintenance of adult stem cells in many organs1,2. Inactivation of Bmi1 leads to impaired stem cell self-renewal due to deregulated gene expression. One critical target of BMI1 is Ink4a/Arf, which encodes the cell-cycle inhibitors p16Ink4a and p19Arf (ref. 3). However, deletion of Ink4a/Arf only partially rescues Bmi1-null phenotypes4, indicating that other important targets of BMI1 exist. Here, using the continuously growing mouse incisor as a model system, we report that Bmi1 is expressed by incisor stem cells and that deletion of Bmi1 resulted in fewer stem cells, perturbed
https://www.nature.com/articles/ncb2766?error=cookies_not_supported&code=7dcf5a32-24a6-427f-9cdf-624e8504b8a6
Items where Subject is R Medicine | RJ Pediatrics Repository - UNAIR REPOSITORYItems where Subject is R Medicine | RJ Pediatrics Repository - UNAIR REPOSITORY
Waluyo, Soegeng (2016) Efek Sistemik Fluoride pada Pertumbuhan dan Perkembangan Jaringan Tubuh Anak. In: Pertemuan Ilmiah Nasional Ke 9 Ilmu Kedokteran Gigi Anak, Maret 2016, Yogyakarta. Waluyo, Soegeng (2013) Peran kalsium sebagai prevensi terjadinya hipoplasia enamel (The role of calcium on enamel hypoplasia prevention). Dental Journal, 46 (3). pp. 113-118. ISSN 1978-3728 Waluyo, Soegeng and ISMIYATIN, K and PURWANTO, B and MUKONO, I.S (2017) The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells. Folia Biologica Journal of Celluler and Molecular Biology, 63. pp. 31-34. Waluyo, Soegeng and Masyitah, Masyitah (2014) Management Children with multiple caries in variety treatment. In: Pertemuan Ilmiah Nasional Ilmu Kedokteran Gigi Anak VII., 8-9 February 2014, Surabaya. Waluyo, Soegeng and Nuraini, Prawati and Pudji Rahayu, Retno and Ismiyatin, Kun (2017) The Effect of NaF on the Existence of Ameloblasts and the Change of Tooth Dimension. Journal of ...
http://repository.unair.ac.id/view/subjects/RJ.html
MJB Journal : Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout...MJB Journal : Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout...
Medicine Journal in MJB authors are : Anas Falah Mahdee,Ahmed Ghanim Alhelal,John Whitworth,Jane Eastham,James Gillespie Evidence For Complex Physiological Processes In The Enamel Organ of The Rodent Mandibular Incisor Throughout Amelogenesis university of babylon journals in the repository for farther content please log to http://repository.uobabylon.edu.iq
http://www.medicaljb.com/article.aspx?jrid=1280
Pitx2, Wnt/-catenin signaling, and microRNAs (miRs) play a critical part in | CDK-II inhibitor KN-62 increase T-cell...Pitx2, Wnt/-catenin signaling, and microRNAs (miRs) play a critical part in | CDK-II inhibitor KN-62 increase T-cell...
Pitx2, Wnt/-catenin signaling, and microRNAs (miRs) play a critical part in the control of teeth control cells during embryonic advancement. well mainly because ameloblast particular elements. The mixture of Pitx2, a regulator of dental care come cells and changes mesenchymal cells to a completely differentiated dental care epithelial cell type. This path and reprogramming can become utilized to reprogram mesenchymal or dental epithelial cells to dental care epithelial (ameloblast) cells, which can become utilized in cells restoration and regeneration research. development of locks follicles, feather pals, mammary placodes, flavor pals, and tooth (4, 11,C17). Wnt/-catenin signaling is definitely needed for multiple phases of teeth advancement and dental care epithelial cell expansion and difference (14). The Lef-1 transcription element manages genetics included in cell expansion and Dihydromyricetin supplier difference. insufficiency causes caught teeth advancement at the bud stage in rodents, ...
http://kn-62.com/pitx2-wnt-catenin-signaling-and-micrornas-mirs-play-a-critical-part-in/
SLC26A Gene Family Participate in pH Regulation during Enamel Maturation - pdf descargar
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abst, Adrast, agrest, agromiast, akatyst, Alcest, aleuroplast, alkahest, alkotest, ameloblast, ametyst, aminoplast, amnioblast, amyloplast, anapest, angioblast, angst, antychryst, Antychryst, antypast, antyrost, antyspast, aoryst, apost, Ast, asyst, atest, audiotekst, Augst, August, august, autopast, awanpost, azbest, Babimost, bakist, balast, balist, batyst, Belfast, berest, Best, biust, blastocyst, bombast, Brest, brzost, burst, canast, celest, chełst, chiroplast, chlast, chloroplast, chlust, chłodnorost, chłost, chondroblast, choroplast, chromoplast, chrust, chrząstkozrost, chrzest, chrzęst, chust, chwast, chwost, ciast, ciepłorost, cist, Coast, conquist, crust, cyst, cytoblast, czelest, czworolist, diatest, Dobrogost, dopust, dost, drapichrust, drzewipest, dst, dunst, duroplast, dygest, dyzgust, East, Economist, Egist, ektoblast, elajoplast, elastoplast, embrioblast, endoblast, enkaust, Enquist, entoblast, epiblast, Ernest, Ernst, erytroblast, est, Everest, Ewaryst, fagocytoblast, ...
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Initial features of the inner dental epithelium histo-morphogenesis in the first lower molar in mouse - Institut de Génomique...Initial features of the inner dental epithelium histo-morphogenesis in the first lower molar in mouse - Institut de Génomique...
H. Lesot, R. Peterkova, R. Schmitt, J. M Meyer, L. Viriot, J. L Vonesch, B. Senger, M. Peterka, and J. V Ruch (1999) Int J Dev Biol, 43(3):245-54.. ...
http://igfl.ens-lyon.fr/publications-avant-igfl/viriot/RN540
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AmphimoeaAmphimoea
Histoire Naturelle des Insectes. Species Général des Lépidoptéres Hétérocéres. Tome Premier. Sphingides, Sésiides, Castnides Hist. nat. Ins., Spec. gén. Lépid. Hétérocères, 1 : 1-568, pl. 1-11 ...
https://ftp.funet.fi/index/Tree_of_life/insecta/lepidoptera/ditrysia/bombycoidea/sphingidae/sphinginae/amphimoea/
AmeloblastAmeloblast
Distal terminal bars are junctional complexes that separate the Tomes' processes from ameloblast proper. Ameloblasts are ... Initially the preameloblasts will differentiate into presecretory ameloblasts and then into secretory ameloblasts which lay ... Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the ... Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross ...
https://en.wikipedia.org/wiki/Ameloblast
Index of oral health and dental articlesIndex of oral health and dental articles
Ameloblast • Ameloblastic fibroma • Ameloblastin • Ameloblastoma • Amelogenesis • Amelogenesis imperfecta • Amelogenin • ...
https://en.wikipedia.org/wiki/Index_of_oral_health_and_dental_articles
AmeloblastomaAmeloblastoma
The ameloblasts cells can be less prominent. Large cysts up to a few centimetres in diameter can be found. In follicular type, ... The most common follicular type has an outer arrangement of columnar or palisaded ameloblasts-like cells and inner zone of ... Ameloblastoma is a rare, benign or cancerous tumor of odontogenic epithelium (ameloblasts, or outside portion, of the teeth ... Resemble a fibro-osseous lesion with no obvious ameloblasts whilst dominated by dense collagenous tissue (desmoplastic). In one ...
https://en.wikipedia.org/wiki/Ameloblastoma
Tooth enamelTooth enamel
Thus, each band on the enamel rod demonstrates the work/rest pattern of the ameloblasts that generally occurs over a span of a ... Both ameloblasts (the cells which initiate enamel formation) and Tomes' processes affect the crystallites' pattern. Enamel ... When this first layer is formed, the ameloblasts move away from the dentin, allowing for the development of Tomes' processes at ... At some point before the tooth erupts into the mouth, but after the maturation stage, the ameloblasts are broken down. ...
https://en.wikipedia.org/wiki/Tooth_enamel
AmelogenesisAmelogenesis
Ameloblasts must also be present for dentinogenesis to continue. A message is sent from the newly differentiated odontoblasts ... It is at this stage that a signal is sent from the newly differentiated ameloblasts back across the dentinoenamel junction (DEJ ... When this first layer is formed, the ameloblasts move away from the interface with dentin, allowing for the development of ... Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, ...
https://en.wikipedia.org/wiki/Amelogenesis
Human tooth developmentHuman tooth development
Ameloblasts make enamel at the location of where the cusps of the teeth are located. Enamel grows outwards, away from the ... As the ameloblasts degenerate, a gingival sulcus is created.[citation needed] Frequently, nerves and blood vessels run parallel ... In summary, the layers in order of innermost to outermost consist of dentin, enamel (formed by IEE, or 'ameloblasts', as they ... Outside the dentin are the newly formed ameloblasts in response to the formation of dentin, which are cells that continue the ...
https://en.wikipedia.org/wiki/Human_tooth_development
Enamel prismEnamel prism
Such is the case in both permanent and primary dentitions; the enamel prisms following the path of the ameloblasts[5]. In ... Relationships between enamel prism decussation and organization of the ameloblast layer in rodent incisors. The Anatomical ...
https://en.wikipedia.org/wiki/Enamel_prism
ODAM (gene)ODAM (gene)
Odontogenic ameloblast-associated protein is a protein that in humans is encoded by the ODAM gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ODAM odontogenic, ameloblast asssociated [sic]". Retrieved 2013-03-31. Moffatt P, Smith CE, Sooknanan R, et al. ( ...
https://en.wikipedia.org/wiki/ODAM_(gene)
BCL11BBCL11B
Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M (March 2009). "Ctip2/Bcl11b controls ameloblast ... Research suggests that BCL11B is crucial for ameloblasts (the cells that produce tooth enamel) to form and work properly. ...
https://en.wikipedia.org/wiki/BCL11B
Tomess processTomes's process
More than one ameloblast contributes to a single prism. Tomes's processes are distinctly different from Tomes's fibers, which ... During the synthesis of enamel, the ameloblast moves away from the enamel, forming a projection surrounded by the developing ... Tomes's processes (also called Tomes processes) are a histologic landmark identified on an ameloblast, cells involved in the ... Tomes's processes are those projections and give the ameloblast a "picket-fence" appearance under a microscope. They are ...
https://en.wikipedia.org/wiki/Tomes's_process
Interrod enamelInterrod enamel
All tooth enamel, including interrod enamel and enamel rods, is made by ameloblasts. However, interrod enamel is formed ...
https://en.wikipedia.org/wiki/Interrod_enamel
TFIP11TFIP11
... localizes to the apical secretory pole of mouse ameloblasts". J Biol Chem. 275 (29): 22284-92. doi:10.1074/jbc.M000118200. PMID ...
https://en.wikipedia.org/wiki/TFIP11
Ameloblastic fibromaAmeloblastic fibroma
The bud-cap stage of normal development shows ameloblasts forming palisades of columnar cells adjacent to a starry-like, ... These proliferate and mature into ameloblasts and fibrous connective tissue (3), and ultimately teeth. Ameloblastic fibromas ...
https://en.wikipedia.org/wiki/Ameloblastic_fibroma
Enamel organEnamel organ
Ameloblast extension rate Duration of ameloblast extension Spreading rate of appositional termination. The appositional growth ... the secretory stage will end and they will transition into maturation stage ameloblasts. These ameloblasts will move down to ... A wave of ameloblasts will then differentiate from the cusp tip and move through the inner enamel epithelia down the slope of ... They are produced by the ameloblast in the bell stage of tooth development. As the crystals are long and closely packed, the ...
https://en.wikipedia.org/wiki/Enamel_organ
Human toothHuman tooth
These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...
https://en.wikipedia.org/wiki/Human_tooth
TuftelinTuftelin
2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 ... localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. UNITED STATES. 275 (29): 22284-92. doi:10.1074/jbc ...
https://en.wikipedia.org/wiki/Tuftelin
Dental anatomyDental anatomy
These cells give rise to ameloblasts, which produce enamel and the reduced enamel epithelium. The growth of cervical loop cells ...
https://en.wikipedia.org/wiki/Dental_anatomy
Odontogenic keratocystOdontogenic keratocyst
The basal cells are an indication of the odontogenic origin as they resemble pre-ameloblasts. The epithelium can separate from ...
https://en.wikipedia.org/wiki/Odontogenic_keratocyst
Inner enamel epitheliumInner enamel epithelium
This layer is first seen during the cap stage, in which these inner enamel epithelium cells are pre-ameloblast cells. These ... will differentiate into Ameloblasts which are responsible for secretion of enamel during tooth development. The location of the ...
https://en.wikipedia.org/wiki/Inner_enamel_epithelium
AmeloblastinAmeloblastin
This protein is formed by ameloblasts during the early secretory to late maturation stages of amelogenesis. Although not ...
https://en.wikipedia.org/wiki/Ameloblastin
Enamel pearlEnamel pearl
Intradental enamel pearls may form during tooth formation, when ameloblasts are invaginated inside the developing dentin. Inner ... these fragments have the potential to develop into functional ameloblasts, which then deposit enamel onto the root surface, ...
https://en.wikipedia.org/wiki/Enamel_pearl
Pitting enamel hypoplasiaPitting enamel hypoplasia
This does not occur in other forms of enamel hypoplasia, such as linear and plane-form, in which all ameloblast activity is ... Each pit is linked to the ceasing of ameloblasts at a particular point in enamel formation. Sometimes, only a couple of ... but all types are associated with a reduction of enamel formation due to disruption in ameloblast production. One of the most ... ameloblasts stop forming enamel, leading to small PEH defects, with large pits forming when hundreds of these enamel-forming ...
https://en.wikipedia.org/wiki/Pitting_enamel_hypoplasia
Junctional epitheliumJunctional epithelium
The ameloblasts also develop hemidesmosomes for the primary EA and become firmly attached to the enamel surface. However, the ... Before the eruption of the tooth and after enamel maturation, the ameloblasts secrete a basal lamina on the tooth surface that ...
https://en.wikipedia.org/wiki/Junctional_epithelium
PangolinPangolin
"Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales". BMC ...
https://en.wikipedia.org/wiki/Pangolin
FAM83HFAM83H
MMP20 is responsible for the breakdown of extracellular matrix and plays a role in tissue remodeling in ameloblasts. mutations ...
https://en.wikipedia.org/wiki/FAM83H
Enamel tuftsEnamel tufts
This is because they are formed by entrapment of odontoblast processes between ameloblasts prior to and during amelogenesis. ...
https://en.wikipedia.org/wiki/Enamel_tufts
Molar incisor hypomineralisationMolar incisor hypomineralisation
More recent evidence has suggested a relationship between respiratory diseases and oxygen shortage of the ameloblasts and MIH. ... due to interruption to the function of ameloblasts. Many factors have been suggested, such as genetics and medical problems ...
https://en.wikipedia.org/wiki/Molar_incisor_hypomineralisation
Calcifying odontogenic cystCalcifying odontogenic cyst
Ameloblast-like proliferation in the connective tissue and lumen of the cyst may be seen. The standard treatment of calcifying ... Additionally, focal areas of stellate reticulum like cells are seen and near the basement membrane ameloblast-like cells may be ...
https://en.wikipedia.org/wiki/Calcifying_odontogenic_cyst
Dentin dysplasiaDentin dysplasia
... or differentiation are mainly due to atypical interaction between odontoblasts and ameloblasts. Histopathologically, deeper ...
https://en.wikipedia.org/wiki/Dentin_dysplasia
Enamel hypocalcificationEnamel hypocalcification
Local trauma or abscess formation can adversely affect the ameloblasts overlying a developing crown, resulting in enamel ...
https://en.wikipedia.org/wiki/Enamel_hypocalcification
Fluoride Action Network | Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblastsFluoride Action Network | Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts
RESULT: High fluoride concentration was associated with decreased ameloblast proliferation, elevated ameloblast apoptosis, and ... Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts. Author: Zhang Y, Zhang K, Ma L, Gu H, Li J, ... Micromolar fluoride alters ameloblast lineage cells in vitro.. Fluorosed enamel is caused by exposure to fluoride during tooth ... To determine the effects of LYC on sodium fluoride (NaF) -induced teeth and ameloblasts toxicity, rats were treated with NaF ( ...
https://fluoridealert.org/studytracker/26689/
Frontiers | Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel...Frontiers | Three-Dimensional Culture of Ameloblast-Originated HAT-7 Cells for Functional Modeling of Defective Tooth Enamel...
Ameloblasts secrete enamel matrix proteins and Ca2+, and also regulate extracellular pH as the formation of hydroxyapatite ... Aims: Our aims were to optimize the culture conditions for the three-dimensional growth of ameloblast-derived HAT-7 cells and ... The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport- ... The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport- ...
https://www.frontiersin.org/articles/10.3389/fphar.2021.682654/full
THE ULTRASTRUCTURE OF AMELOBLASTS DURING MATRIX FORMATION AND THE MATURATION OF ENAMEL | Journal of Cell Biology | Rockefeller...THE ULTRASTRUCTURE OF AMELOBLASTS DURING MATRIX FORMATION AND THE MATURATION OF ENAMEL | Journal of Cell Biology | Rockefeller...
Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. During matrix ... THE ULTRASTRUCTURE OF AMELOBLASTS DURING MATRIX FORMATION AND THE MATURATION OF ENAMEL Edward J. Reith Edward J. Reith ... Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. During matrix ... In the most incisal region, the ameloblasts are further reduced in height. Distal processes are no longer present and fibrils ...
https://rupress.org/jcb/article/9/4/825/19544/THE-ULTRASTRUCTURE-OF-AMELOBLASTS-DURING-MATRIX
Ameloblasts | Profiles RNS
"Ameloblasts" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Ameloblasts" by people in this website by year, and whether " ... Below are the most recent publications written about "Ameloblasts" by people in Profiles. ...
https://profiles.jefferson.edu/display/6317
Developmental BiologyDevelopmental Biology
G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. Journal of Biological ... Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell ameloblast-secreted enamel matrices ... Enamel mineralization occurs in a strictly synchronized manner along with ameloblast maturation in association with ion ...
https://www.jbc.org/Developmental-Biology?startPage=&ContribAuthorRaw=Saito%2C%20Kan
The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts<...
The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ... The application of synchrotron radiation induced X-ray emission in the measurement of zinc and lead in Wistar rat ameloblasts. ...
https://scholars.mssm.edu/en/publications/the-application-of-synchrotron-radiation-induced-x-ray-emission-i-2
FAM83H gene: MedlinePlus GeneticsFAM83H gene: MedlinePlus Genetics
The protein is found in several types of cells, including specialized cells called ameloblasts. Ameloblasts produce tooth ...
https://medlineplus.gov/genetics/gene/fam83h/
Shh and fluoride - PFPC Fluoride Education Project
Results Shh secretory ameloblasts in, odontoblasts expression. Shh expression in the experimental group was significantly ... The results of the study, the results of immunohistochemistry for the control rats ameloblasts smad3, shh expression is ... Conclusion: In the late incisor development,Shh might participate in the ameloblast and odontoblast differentiation as a ... Immunostaining for shh was detected in dental epithelium , oral epithelium, and ameloblasts. Shh was weakly expressed in ...
https://poisonfluoride.com/phpBB3/viewtopic.php?f=12&p=4697
Pathology and Laboratory Science - Research output - the UWA Profiles and Research Repository
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss | Scientific ReportsDeficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss | Scientific Reports
Odontogenic ameloblast-associated protein) and dentin dysplasia targets (Dentin matrix acidic phosphoprotein 1). We tested if ... Reduction of odontogenic ameloblast-associated protein (Odam), encoding a secreted protein guiding early enamel formation, ... Odontogenic ameloblast-associated protein) and dentin dysplasia targets (Dentin matrix acidic phosphoprotein 1). We tested if ...
https://www.nature.com/articles/s41598-020-71749-6?error=cookies_not_supported&code=55be3a3e-d4cc-4483-bef6-a9d2ebbf48af
Human Dentin Matrix Acidic phosphoprotein 1 (DMP1) Protein (His tag), Recombinant | ABIN1691401Human Dentin Matrix Acidic phosphoprotein 1 (DMP1) Protein (His tag), Recombinant | ABIN1691401
DMP-1 is expressed in teeth particularly in odontoblast, ameloblast, and cementoblast. DMP-1 is critical for proper ...
https://www.antikoerper-online.de/protein/1691401/Dentin+Matrix+Acidic+phosphoprotein+1+DMP1+AA+17-513+protein+His+tag/
DailyMed - ALECENSA- alectinib hydrochloride capsuleDailyMed - ALECENSA- alectinib hydrochloride capsule
... in teeth included discoloration and changes in tooth size along with histopathological disarrangement of the ameloblast and ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=42c49deb-713b-427a-9670-08af08adcffb
Microtree - Ejvis LamaniMicrotree - Ejvis Lamani
2011) Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. Plos One. 6: e24281. ...
https://academictree.org/microbiology/peopleinfo.php?pid=402573
Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injuryRoles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury
Zhang Y, Zhang K, Ma L, Gu H, Li J, Lei S. Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts. ...
https://www.wjgnet.com/1948-9358/full/v13/i4/338.htm
1 - Ig index trading signals
Correlarion of 45Ca incorporation with maturation ameloblast morphology in the rat incisor. The effect is used in insex Effect ...
http://forextrading-madeeasy.com/ig-index-trading-signals.html
Supporting Oral Health in Patients With Cystic Fibrosis - Dimensions of Dental Hygiene | MagazineSupporting Oral Health in Patients With Cystic Fibrosis - Dimensions of Dental Hygiene | Magazine
The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and ...
https://dimensionsofdentalhygiene.com/article/supporting-oral-health-in-patients-with-cystic-fibrosis/
Newly discovered gene could aid in enhanced dental treatment - Health JockeyNewly discovered gene could aid in enhanced dental treatment - Health Jockey
This is the first transcription factor ever found to control the formation and maturation of ameloblasts, which are the cells ...
https://www.healthjockey.com/2009/02/25/newly-discovered-gene-could-aid-in-enhanced-dental-treatment/
Role of Some Natural Antioxidants in the Modulation of Some Proteins Expressions against Sodium Fluoride-Induced Renal InjuryRole of Some Natural Antioxidants in the Modulation of Some Proteins Expressions against Sodium Fluoride-Induced Renal Injury
A. Bronckers, D. Lyaruu, and P. DenBesten, "The Impact of Fluoride on Ameloblasts and the Mechanisms of Enamel Fluorosis," ...
https://www.hindawi.com/journals/bmri/2018/5614803/
Fluorine and fluorides (EHC 36, 1984)Fluorine and fluorides (EHC 36, 1984)
Several concepts may be relevant to the etiological mechanism of dental fluorosis: the enamel-forming cells, the ameloblasts, ...
https://inchem.org/documents/ehc/ehc/ehc36.htm
Cyclopamine Decreased the Expression of Sonic Hedgehog and its Downstream Genes in Colon Cancer Stem Cells | Anticancer ResearchCyclopamine Decreased the Expression of Sonic Hedgehog and its Downstream Genes in Colon Cancer Stem Cells | Anticancer Research
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development ...
https://ar.iiarjournals.org/content/34/11/6339.full
SciELO RevOdonto - revodonto.bvsalud.orgSciELO RevOdonto - revodonto.bvsalud.org
Enamel mineralization in the absence of maturation stage ameloblasts. Arch Oral Biol. 2009;54(4):313-21. * Google ...
http://revodonto.bvsalud.org/scielo.php?script=sci_nlinks&ref=490278&pid=S1519-4442201300010000200023&lng=pt
Fluoride: Double-Edged Sword Implicated in Caries Prevention and in FluorosisFluoride: Double-Edged Sword Implicated in Caries Prevention and in Fluorosis
Secretory ameloblasts. These are relatively resistant to the effects of acute fluoride exposure in comparison with early- and ... Maturation ameloblasts. Although maturation-stage enamel seems to be most sensitive to fluoride, there are remarkably few ... A single higher dose of fluoride (9 mg F/kg body weight) induces cyst formation by early-secretory ameloblasts in the cervical ... Cellular changes in secretory ameloblasts in vivo are reported only after the injection of high levels of fluoride. One or ...
https://scholars.direct/Articles/cell-and-developmental-biology/jcdb-1-002.php?jid=cell-and-developmental-biology
Pesquisa | BVS OdontologiaPesquisa | BVS Odontologia
Trafficking and secretion of keratin 75 by ameloblasts in vivo. Yang, Xu; Yamazaki, Hajime; Yamakoshi, Yasuo; Duverger, Olivier ...
https://pesquisa.bvsalud.org/odontologia/?lang=pt&q=au:Morasso,+Maria
Hypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. - OzgeneHypomaturation enamel defects in Klk4 knockout/LacZ knockin mice. - Ozgene
No X-gal staining was observed in secretory stage ameloblasts or in odontoblasts. Retained enamel proteins were observed in the ... staining demonstrated expression of beta-galactosidase in maturation stage ameloblasts. ...
https://www.ozgene.com/publications/hypomaturation-enamel-defects-in-klk4-knockoutlacz-knockin-mice/
cell | Tabers Medical Dictionarycell | Taber's Medical Dictionary
SEE: ameloblast. amine precursor uptake and decarboxylation cell. ABBR: APUD cell Any of the constituent cells of a diffuse ...
https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/734233/all/multi_potential_progenitor_cell
DeCSDeCS
Ameloblasts - Preferred Concept UI. M0000884. Scope note. Cylindrical epithelial cells in the innermost layer of the ENAMEL ...
https://decs.bvsalud.org/en/ths/resource/?id=566
The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma...The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma...
... and early ameloblast development, the enamel organ precursor (Laurenti et al., Dev Dyn 230:727, 2004). dax1 is initially ... and early ameloblast development, the enamel organ precursor (Laurenti et al., Dev Dyn 230:727, 2004). dax1 is initially ...
https://escholarship.org/uc/item/6mm0d9jk
Restriction of sonic hedgehog signalling during early tooth development | Development | The Company of BiologistsRestriction of sonic hedgehog signalling during early tooth development | Development | The Company of Biologists
... and the epithelium differentiates into enamel-secreting ameloblasts. ...
https://journals.biologists.com/dev/article/131/12/2875/42222/Restriction-of-sonic-hedgehog-signalling-during
Maturation stage ameloblastsSecretoryOdontoblastCellsMineralizationEpithelial cellSecrete enamelDifferentiationToothEpitheliumVivoMeSHFluorideTransitionalDistalRatsConcentrationsDentinStageTeethDentalFormationOdontoblastsEpithelialAnalyzing ameloblast differentiationAmelogenesisMaturationEnamel hypoplasiaTooth enamelAmeloblastinIncisorDental enamelCellularSecretionTissueMiceIncisorsMouseLayerStudy
Maturation stage ameloblasts2
  • Enamel mineralization in the absence of maturation stage ameloblasts. (bvsalud.org)
  • Histochemical X-gal (5-bromo-4-chloro-3-indolyl-beta-d-galactopyranoside) staining demonstrated expression of beta-galactosidase in maturation stage ameloblasts. (ozgene.com)
Secretory3
  • No X-gal staining was observed in secretory stage ameloblasts or in odontoblasts. (ozgene.com)
  • In the secretory stage, ameloblasts are polarized columnar cells. (regencydentalgroupblog.com)
  • These signs demonstrate that the ameloblasts have changed their function from production, as in the secretory stage, to transportation. (regencydentalgroupblog.com)
Odontoblast1
  • DMP-1 is expressed in teeth particularly in odontoblast, ameloblast, and cementoblast. (antikoerper-online.de)
Cells10
  • METHODS: We cultured and exposed rat ameloblast HAT-7 cells to various concentrations of fluoride and measured apoptosis with flow cytometry and intracellular Ca2+ changes using confocal microscopy, investigated the protein levels of GRP78, calreticulin, XBP1 and CHOP by western blotting, and their transcriptional levels with RT-PCR. (fluoridealert.org)
  • Our aims were to optimize the culture conditions for the three-dimensional growth of ameloblast-derived HAT-7 cells and to test the effects of fluoride exposure on HAT-7 spheroid formation. (frontiersin.org)
  • The cells retained their epithelial cell morphology and continued to express both ameloblast-specific and ion transport-specific marker genes. (frontiersin.org)
  • However, these primary ameloblast-like cells can be passaged only 3 times, and so have limited use in studies of ameloblast function. (frontiersin.org)
  • The protein is found in several types of cells, including specialized cells called ameloblasts. (medlineplus.gov)
  • The results were clas- effects on the ameloblast cells during the sified according to age and severity. (who.int)
  • 2011 ) Adenovirus gene transfer to amelogenesis imperfecta ameloblast-like cells. (academictree.org)
  • This is the first transcription factor ever found to control the formation and maturation of ameloblasts, which are the cells that secrete enamel. (healthjockey.com)
  • Circadian clock genes are present in the ameloblasts, odontoblasts, and dental pulp cells. (bvsalud.org)
  • Amelogenesis, or enamel formation, occurs after the first establishment of dentin, via cells known as ameloblasts. (regencydentalgroupblog.com)
Mineralization1
  • Enamel mineralization occurs in a strictly synchronized manner along with ameloblast maturation in association with ion transport and pH balance, and any disruption of these processes results in enamel hypomineralization. (jbc.org)
Epithelial cell1
  • Dental enamel, the hardest tissue in the human body, is derived from dental epithelial cell ameloblast-secreted enamel matrices. (jbc.org)
Secrete enamel1
  • Ameloblasts secrete enamel matrix proteins and Ca 2+ , and also regulate extracellular pH as the formation of hydroxyapatite crystals generates large quantities of protons. (frontiersin.org)
Differentiation1
  • Ameloblast differentiation and ion transport activities have primarily been investigated by immunohistochemistry and characterization of the enamel phenotypes of knockout mouse models. (frontiersin.org)
Tooth4
  • Ameloblasts produce tooth enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth. (medlineplus.gov)
  • Recently, eve1 has been shown to be associated with the primary tooth (4V1) and early ameloblast development, the enamel organ precursor (Laurenti et al. (escholarship.org)
  • At some point before the tooth erupts into the mouth, but after the maturation stage, the ameloblasts are broken down. (regencydentalgroupblog.com)
  • Recent studies have shown alterations during tooth morphogenesis in Jagged2-/- mutant mice, accompanied by defects in ameloblasts cytodifferentiation and poor enamel matrix deposition. (udea.edu.co)
Epithelium1
  • Ameloblasts, derived from the oral epithelium, are known to secrete proteins and Ca 2+ into the enamel extracellular matrix. (frontiersin.org)
Vivo2
  • CONCLUSIONS: These results indicate that exposure to high levels of fluoride led to endoplasmic reticulum stress which induced apoptosis in cultured ameloblasts and in vivo rat model, suggesting an important role of calcium overload and endoplasmic reticulum stress triggered by high concentrations of fluoride in the development of dental fluorosis. (fluoridealert.org)
  • Trafficking and secretion of keratin 75 by ameloblasts in vivo . (bvsalud.org)
MeSH1
  • Ameloblasts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
Fluoride1
  • RESULT: High fluoride concentration was associated with decreased ameloblast proliferation, elevated ameloblast apoptosis, and increased intracellular Ca2+ in vitro. (fluoridealert.org)
Transitional2
  • The next incisal region is a transitional zone in which the ameloblasts separate easily from the enamel. (rupress.org)
  • and transitional ameloblasts (Ruffle- to smooth-ended ameloblasts, R-SA). (nii.ac.jp)
Distal3
  • Specimens were fixed by perfusion with 0.5% formaldehyde and 0.5% glutaraldehyde followed by decalcification, then freeze-cracked and treated with dilute osmium tetroxide to digest the dense lamina lining the distal surface of the ameloblasts. (nii.ac.jp)
  • In these ameloblasts, small granules, presumably connecting the dense lamina to the distal surface of the ameloblasts, were also visible. (nii.ac.jp)
  • The distal surface of rat incisor ameloblasts at the early stage of enamel maturation was investigated by high resolution scanning electron microscopy (SEM). (nii.ac.jp)
Rats1
  • Ameloblasts from different regions of upper incisors of rats were examined with the electron microscope. (rupress.org)
Concentrations1
  • A clear lead signal above the background was not detected in the ameloblasts and lead concentrations could only be reliably measured in the developing enamel. (mssm.edu)
Dentin2
  • Whole-genome RNA-sequencing analysis of embryonic day (E) 14.5 cap stage molars revealed reductions in early expressed enamel matrix components ( Odontogenic ameloblast-associated protein ) and dentin dysplasia targets ( Dentin matrix acidic phosphoprotein 1 ). (nature.com)
  • When this first layer is formed, the ameloblasts move away from the dentin, allowing for the development of Tomes' processes at the apical pole of the cell. (regencydentalgroupblog.com)
Stage1
Teeth1
  • The present study describes for the first time the application of synchrotron radiation induced X-ray emission (SRIXE) in measuring the distribution of zinc and lead in the ameloblasts of developing Wistar rat teeth. (mssm.edu)
Dental1
  • Las futuras investigaciones abordadas desde la visión translacional ayudarán estética dental, a identificar nuevas mutaciones o nuevos genes, lo cual contribuirá a la evolución en la manera de clasificar, genes. (bvsalud.org)
Formation1
  • Enamel formation continues around the adjoining ameloblasts, resulting in a walled area, or pit, that houses a Tomes' process, and also around the end of each Tomes' process, resulting in a deposition of enamel matrix inside of each pit. (regencydentalgroupblog.com)
Odontoblasts11
  • Odontoblasts can also be affected, but ameloblasts appear to be more sensitive. (nih.gov)
  • 12. GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts. (nih.gov)
  • May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. (uniprot.org)
  • We have found that MMP-20 transcripts are produced early in development in both the ameloblasts of the enamel organ and the odontoblasts of the pulp organ. (forsyth.org)
  • Dentin first appears in the layer between the ameloblasts and odontoblasts and becomes calcified immediately. (lookformedical.com)
  • Not even one sentence on how teeth were invented, how they evolved, how ameloblasts formed (cells that knit enamel), how odontoblasts formed (cells that knit dentin), how these cells placed themselves in the jaws, how they know exactly how and when to start and stop knitting so that a perfectly sculptured tooth will be the result……and on and on. (evoillusion.org)
  • Once the cells that form dentin (odontoblasts) and enamel (ameloblasts) finish forming teeth, they die. (smilesbypayet.com)
  • Localization was observed in osteoblasts, ameloblasts and odontoblasts from the developing incisor in day time 1 and 3. (bmn-673.com)
  • Odontomas are developmental anomalies due to complete differentiation of epithelial and mesenchymal cells resulting in fully functional ameloblasts and odontoblasts. (kidznteenz.in)
  • Dental pulp and enamel biology including cellular, molecular and structural aspects of dentin-pulp complex, cementoblasts, odontoblasts, ameloblasts in both normal and pathological conditions. (nih.gov)
  • Primarily pre-ameloblasts which abutted on the dental papilla differentiate the condensed mesenchymal cells into odontoblasts, and secondarily matured odontoblasts which bulged into enamel epithelium produced dentin matrix and differentiated the shrunken pre-ameloblasts into ameloblasts. (jpatholtm.org)
Epithelial2
  • The present study was designed to investigate whether a three dimensional (3D) culture of the rat incisor-derived dental epithelial cell line SF2 enhances its differentiation into ameloblast-like cells. (elsevier.com)
  • 21. Lourenço SQC, Consolaro A. Apoptosis in odontogenesis: dental lamina, Hertwig's epithelial sheath and reduced ameloblasts. (bvsalud.org)
Analyzing ameloblast differentiation1
  • Overall our results suggest that the spheroid culture could be a useful model for analyzing ameloblast differentiation. (elsevier.com)
Amelogenesis1
  • In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harbors bovine amelogenin promoter-driven Cre recombinase, and bred this line with TGF-ß receptor II floxed mice to generate ameloblast-specific TGF-ß receptor II conditional knockout (cKO) mice. (harvard.edu)
Maturation2
  • We have demonstrated that acid raises fluoride toxicity which the acidity environment from the maturation stage makes ameloblasts even more vunerable to the poisonous ramifications of fluoride publicity [13]. (chk1inhibitors.com)
  • Thus, our study indicates that TGF-ß signaling plays an important role in ameloblast functions and enamel maturation. (harvard.edu)
Enamel hypoplasia1
  • 17. Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice. (nih.gov)
Tooth enamel2
  • Ameloblasts produce tooth enamel, which is the hard, calcium-rich material that forms the protective outer layer of each tooth. (medlineplus.gov)
  • The ectodermal portion forms the enamel organ ( ameloblasts ) that forms the hard tooth enamel layer. (embryology.ch)
Ameloblastin2
  • 7. Essential roles of ameloblastin in maintaining ameloblast differentiation and enamel formation. (nih.gov)
  • Co-immunoprecipitation assay of mouse ameloblast cell lysates with either ameloblastin or Psma3 antibody identified each reciprocal protein partner. (divbiolchem.org)
Incisor1
  • We used microarray technology to compare the expression of miRNAs in three regions of the adult mouse incisor: the laCL, liCL, and ameloblasts. (escholarship.org)
Dental enamel3
  • 5. Ameloblasts require active RhoA to generate normal dental enamel. (nih.gov)
  • The elaboration of dental enamel by ameloblasts , beginning with its participation in the formation of the dentino-enamel junction to the production of the matrix for the enamel prisms and interprismatic substance. (lookformedical.com)
  • 2015-5-26 · Dental enamel is produced by ameloblasts. (actioncams.club)
Cellular2
  • Whenever present, ameloblast atrophy should be diagnosed and graded based on the degree of cellular atrophy and the number of ameloblasts affected. (nih.gov)
  • At this cellular level, it becomes incorporated into the enamel-forming ameloblasts. (fluoridealert.org)
Secretion2
  • 1. The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation. (nih.gov)
  • Trafficking and secretion of keratin 75 by ameloblasts in vivo . (bvsalud.org)
Tissue1
  • Enamel is a bioceramic tissue composed of thousands of hydroxyapatite crystallites aligned in parallel within boundaries fabricated by a single ameloblast cell. (divbiolchem.org)
Mice1
Incisors1
  • 19. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. (nih.gov)
Mouse1
  • Figure Legend: Figure 1 Normal ameloblasts (arrow) in a male B6C3F1 mouse from a chronic study. (nih.gov)
Layer1
  • The ameloblast layer is thin (compare with Figure 1), due to the decreased size of the ameloblasts (arrow). (nih.gov)
Study1
  • Figure 2 Tooth, Ameloblast - Atrophy in a male F344/N rat from a chronic study. (nih.gov)
FAM83H gene: MedlinePlus Genetics
FAM83H gene: MedlinePlus Genetics (medlineplus.gov)
Begriffe mit A | Medizin-Lexikon | gesundheit.de
Begriffe mit A | Medizin-Lexikon | gesundheit.de (gesundheit.de)
The_pivot_of_civilization [Brian Carnell's Wiki]
The_pivot_of_civilization [Brian Carnell's Wiki] (brian.carnell.com)
Pathology and Laboratory Science - Research output - the UWA Profiles and Research Repository
Pathology and Laboratory Science - Research output - the UWA Profiles and Research Repository (research-repository.uwa.edu.au)
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss | Scientific Reports
Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss | Scientific Reports (nature.com)
DailyMed - ALECENSA- alectinib hydrochloride capsule
DailyMed - ALECENSA- alectinib hydrochloride capsule (dailymed.nlm.nih.gov)
Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury
Roles of transient receptor potential channel 6 in glucose-induced cardiomyocyte injury (wjgnet.com)
Supporting Oral Health in Patients With Cystic Fibrosis - Dimensions of Dental Hygiene | Magazine
Supporting Oral Health in Patients With Cystic Fibrosis - Dimensions of Dental Hygiene | Magazine (dimensionsofdentalhygiene.com)
Role of Some Natural Antioxidants in the Modulation of Some Proteins Expressions against Sodium Fluoride-Induced Renal Injury
Role of Some Natural Antioxidants in the Modulation of Some Proteins Expressions against Sodium Fluoride-Induced Renal Injury (hindawi.com)
Cyclopamine Decreased the Expression of Sonic Hedgehog and its Downstream Genes in Colon Cancer Stem Cells | Anticancer Research
Cyclopamine Decreased the Expression of Sonic Hedgehog and its Downstream Genes in Colon Cancer Stem Cells | Anticancer Research (ar.iiarjournals.org)
Fluoride: Double-Edged Sword Implicated in Caries Prevention and in Fluorosis
Fluoride: Double-Edged Sword Implicated in Caries Prevention and in Fluorosis (scholars.direct)
SciELO RevOdonto - revodonto.bvsalud.org
SciELO RevOdonto - revodonto.bvsalud.org (revodonto.bvsalud.org)
Cell | Taber's Medical Dictionary
Cell | Taber's Medical Dictionary (nursing.unboundmedicine.com)
The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma...
The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma... (escholarship.org)
Find Research outputs - Augusta University Research Profiles
Find Research outputs - Augusta University Research Profiles (augusta.pure.elsevier.com)
Proceedings of the 2018 National Toxicology Program Satellite Symposium<...
Proceedings of the 2018 National Toxicology Program Satellite Symposium<... (ohsu.pure.elsevier.com)
Search | Page 2 | The Embryo Project Encyclopedia
Search | Page 2 | The Embryo Project Encyclopedia (embryo.asu.edu)
Laboratory of Skin Biology | NIAMS
Laboratory of Skin Biology | NIAMS (niams.nih.gov)
Mandibular Cysts and Odontogenic Tumors: Overview, Odontogenic Mandibular Cysts, Nonodontogenic Mandibular Cysts
Mandibular Cysts and Odontogenic Tumors: Overview, Odontogenic Mandibular Cysts, Nonodontogenic Mandibular Cysts (emedicine.medscape.com)
Mandibular Cysts and Odontogenic Tumors: Overview, Odontogenic Mandibular Cysts, Nonodontogenic Mandibular Cysts
Mandibular Cysts and Odontogenic Tumors: Overview, Odontogenic Mandibular Cysts, Nonodontogenic Mandibular Cysts (emedicine.medscape.com)
These highlights do not include all the information needed to use DAURISMO safely and effectively. See full prescribing...
These highlights do not include all the information needed to use DAURISMO safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)