Amdinocillin Pivoxil
Enterobacteriaceae
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alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
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tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin. (1/94)
In previous studies we demonstrated that mutations in the genes cysB, cysE, and cls (nov) affect resistance of Escherichia coli to novobiocin (J. Rakonjac, M. Milic, and D. J. Savic, Mol. Gen. Genet. 228:307-311, 1991; R. Ivanisevic, M. Milic, D. Ajdic, J. Rakonjac, and D. J. Savic, J. Bacteriol. 177:1766-1771, 1995). In this work we expand this list with mutations in rpoN (the gene for RNA polymerase subunit sigma54) and the tRNA synthetase genes alaS, argS, ileS, and leuS. Similarly to resistance to the penicillin antibiotic mecillinam, resistance to novobiocin of tRNA synthetase mutants appears to depend upon the RelA-mediated stringent response. However, at this point the overlapping pathways of mecillinam and novobiocin resistance diverge. Under conditions of stringent response induction, either by the presence of tRNA synthetase mutations or by constitutive production of RelA protein, inactivation of the cls gene diminishes resistance to novobiocin but not to mecillinam. (+info)A Canadian national surveillance study of urinary tract isolates from outpatients: comparison of the activities of trimethoprim-sulfamethoxazole, ampicillin, mecillinam, nitrofurantoin, and ciprofloxacin. The Canadian Urinary Isolate Study Group. (2/94)
Ampicillin, trimethoprim-sulfamethoxazole, mecillinam, nitrofurantoin, and ciprofloxacin mean resistance rates for 2,000 urinary tract isolates collected from outpatients across Canada in 1998 were 41.1, 19.2, 14.7, 5.0, and 1.8%, respectively. For Escherichia coli isolates alone (n = 1,681) comparable rates were 41. 0, 18.9, 7.4, 0.1, and 1.2%, respectively. The majority of E. coli isolates resistant to ampicillin, trimethoprim-sulfamethoxazole, or ciprofloxacin were susceptible (MIC, <16 microg/ml) to mecillinam. (+info)Selected amplification of the cell division genes ftsQ-ftsA-ftsZ in Escherichia coli. (3/94)
Rapidly growing Escherichia coli is unable to divide in the presence of the antibiotic mecillinam, whose direct target is penicillin-binding protein 2 (PBP2), responsible for the elongation of the cylindrical portion of the cell wall. Division can be restored in the absence of PBP2 activity by increasing the concentration of the cell division proteins FtsQ, FtsA, and FtsZ. We tried to identify regulators of the ftsQ-ftsA-ftsZ operon among mecillinam-resistant mutants, which include strains overexpressing these genes. By insertional mutagenesis with mini-Tn10 elements, we selected for insertions that conferred mecillinam resistance. Among 15 such mutants, 7 suppressed the thermosensitivity of the ftsZ84(Ts) mutant, strongly suggesting that they had increased FtsZ activity. In all 7 cases, however, the mutants resulted from a duplication of the ftsQAZ region. These duplications seemed to result from multiple events, suggesting that no simple insertional inactivation can result in a mutant with sufficiently amplified ftsQAZ expression to confer mecillinam resistance. The structure of the duplications suggests a general method for constructing directed duplications of precise sequences. (+info)Affinities of beta-lactams for penicillin binding proteins of Chlamydia trachomatis and their antichlamydial activities. (4/94)
Binding affinities of beta-lactam antibiotics for the three penicillin binding proteins (PBPs) from Chlamydia trachomatis were determined in vitro and compared with their antichlamydial activities. Mecillinam selectively inhibited PBP1, with a 50% inhibitory concentration for PBP1 binding (0.2 microg/ml) similar to the MIC (0.1 microg/ml) and minimum bactericidal concentration (0.25 microg/ml). Although the other beta-lactams inhibited a wider range of PBPs than mecillinam, their antichlamydial activities were inferior to that of mecillinam. (+info)Constitutive septal murein synthesis in Escherichia coli with impaired activity of the morphogenetic proteins RodA and penicillin-binding protein 2. (5/94)
The pattern of peptidoglycan (murein) segregation in cells of Escherichia coli with impaired activity of the morphogenetic proteins penicillin-binding protein 2 and RodA has been investigated by the D-cysteine-biotin immunolabeling technique (M. A. de Pedro, J. C. Quintela, J.-V. Holtje, and H. Schwarz, J. Bacteriol. 179:2823-2834, 1997). Inactivation of these proteins either by amdinocillin treatment or by mutations in the corresponding genes, pbpA and rodA, respectively, leads to the generation of round, osmotically stable cells. In normal rod-shaped cells, new murein precursors are incorporated all over the lateral wall in a diffuse manner, being mixed up homogeneously with preexisting material, except during septation, when strictly localized murein synthesis occurs. In contrast, in rounded cells, incorporation of new precursors is apparently a zonal process, localized at positions at which division had previously taken place. Consequently, there is no mixing of new and old murein. Old murein is preserved for long periods of time in large, well-defined areas. We propose that the observed patterns are the result of a failure to switch off septal murein synthesis at the end of septation events. Furthermore, the segregation results confirm that round cells of rodA mutants do divide in alternate, perpendicular planes as previously proposed (K. J. Begg and W. D. Donachie, J. Bacteriol. 180:2564-2567, 1998). (+info)Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. (6/94)
Random screening for inhibitors of chromosome partitioning in Escherichia coli was done by the anucleate cell blue assay. A novel S-benzylisothiourea derivative, S-(3,4-dichlorobenzyl)isothiourea, tentatively named A22, was found to induce spherical cells and spherical anucleate cells in E. coli. Mecillinam, a specific inhibitor of penicillin-binding protein 2, which induces spherical cells in E. coli, also caused anucleate cell production. Spherical cells induced by treatment with either A22 or mecillinam varied in size, and anucleate cells seemed to be more frequent among the smaller cells. These results suggest that loss of the rod shape in E. coli leads to asymmetric cell division that results in production of anucleate cells. No competition was observed even in the presence of a 10-fold excess A22 in an in vitro assay of 14C-penicillin G binding, but mecillinam specifically inhibited binding of 14C-penicillin G to penicillin-binding protein 2. Simultaneous treatment with mecillinam and cephalexin, a specific inhibitor of penicillin-binding protein 3, induced lysis of E. coli cells, but a combination of A22 and cephalexin did not. These results suggest that the target molecule(s) of A22 was not penicillin-binding protein 2. A22 may act on a rod-shape-determining protein(s) other than penicillin-binding protein 2, such as RodA or MreB. (+info)Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. (7/94)
Resistance to antibiotics used for the treatment of urinary tract infections (UTIs) is increasing worldwide. The impact of in vitro resistance on clinical outcome in UTIs requires further study, since most studies of both humans and animals have evaluated only the efficacy of antibiotics toward bacteria susceptible in vitro. We were interested in evaluating the relationship between the in vitro antibacterial effect and the in vivo efficacy after antibiotic treatment. We simulated a natural ascending UTI by use of the ascending UTI mouse model and used Escherichia coli strains with various susceptibilities to amdinocillin (mecillinam) and sulfamethizole. Mice were treated for 3 days with antibiotic doses approximating human urinary tract concentrations after a standard oral dose. For a susceptible strain (MIC, 0.5 micro g/ml) and a resistant strain (MIC, 128 micro g/ml), respectively, there were significant reductions in bacterial counts in the urine, bladder, and kidneys after treatment with amdinocillin, whereas for a strain for which the MIC was 16 micro g/ml, there was a significant reduction in bacterial counts in the kidneys only (P < 0.05). Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys. For amdinocillin, there was no clear-cut relationship between the in vitro susceptibility and the in vivo outcome, while for sulfamethizole, we found a relationship between the MIC for the strain and the effect in the urinary tract. (+info)The pharmacokinetics of mecillinam and pivmecillinam in pregnant and non-pregnant women. (8/94)
1. The pharmacokinetics of parenteral mecillinam (n = 27) and oral pivmecillinam (n = 12) were studied in pregnant (n = 27) and non-pregnant (n = 12) subjects. 2. In early pregnancy (9-14 weeks of gestation) the mean peak plasma drug concentration (Cmax = 19 +/- 9 micrograms ml-1) after an intravenous injection of 200 mg mecillinam was significantly lower (P less than 0.05) and the volume of distribution (V = 49 +/- 20.1) significantly larger (P less than 0.05) than in non-pregnant subjects (Cmax = 35 +/- 18 micrograms ml-1, V = 29 +/- 12.1). In late pregnancy (39-40 weeks of gestation) the plasma mean peak concentration (Cmax = (29 +/- 14 micrograms ml-1) after parenteral administration of 200 mg mecillinam was slightly lower and the volume of distribution (V = 65 +/- 29.1, V = 0.9 +/- 0.4 l kg-1) significantly larger than that in non-pregnant subjects (V = 0.4 +/- 0.3 l kg-1). Also after oral administration of 200 mg pivmecillinam, equimolar to 136.5 mg mecillinam, the mean peak plasma concentration in pregnant subjects (Cmax = 1.8 +/- 1.2 micrograms ml-1) was slightly lower than that in non-pregnant subjects (Cmax = 1.7 +/- 1.2 micrograms ml-1). 3. The mean half-life of elimination after parenteral administration of mecillinam was significantly longer during both early (t1/2,Z = 133 +/- 38 min, P less than 0.05) and late pregnancy (t1/2,Z = 107 +/- 41 min, P less than 0.05) as compared with the non-pregnant state (t1/2,Z = 75 +/- 21 min).(ABSTRACT TRUNCATED AT 250 WORDS) (+info)
Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...
Amdinocillin (Mecillinam) | Johns Hopkins ABX Guide
Penicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants. | Journal of Bacteriology
Mutations in Cell Elongation Genes mreB, mrdA and mrdB Suppress The Shape Defect of RodZ-Deficient Cells.
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Mecillinam
... (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds ... Neu HC (1985). "Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use". Pharmacotherapy. 5 (1 ... Pham P, Bartlett JG (August 28, 2008). "Amdinocillin (Mecillinam)". Point-of-Care Information Technology ABX Guide. Johns ...
Chlortetracycline
The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination ...
Sulfamethizole
Kerrn M, Frimodt-Møller N, Espersen F (2003). "Effects of Sulfamethizole and Amdinocillin against Escherichia coli Strains ( ...
Pivmecillinam
... (INN) or amdinocillin pivoxil (USAN, trade names Selexid, Penomax and Coactabs) is an orally active prodrug of ...
List of MeSH codes (D03)
... amdinocillin MeSH D03.438.260.825.124.036 - amdinocillin pivoxil MeSH D03.438.260.825.249 - cyclacillin MeSH D03.438.260.825. ... amdinocillin MeSH D03.605.084.737.124.036 - amdinocillin pivoxil MeSH D03.605.084.737.249 - cyclacillin MeSH D03.605.084.737. ...
Amdinocillin | definition of amdinocillin by Medical dictionary
... amdinocillin explanation free. What is amdinocillin? Meaning of amdinocillin medical term. What does amdinocillin mean? ... Looking for online definition of amdinocillin in the Medical Dictionary? ... Amdinocillin , definition of amdinocillin by Medical dictionary https://medical-dictionary.thefreedictionary.com/amdinocillin ... amdinocillin. Also found in: Dictionary, Thesaurus, Encyclopedia. penicillin. [pen″ĭ-sil´in] any of a large group of natural or ...
Amdinocillin | Harvard Catalyst Profiles | Harvard Catalyst
"Amdinocillin" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Amdinocillin" by people in Harvard Catalyst Profiles by year, ... Pharmacokinetics of intravenous amdinocillin in healthy subjects and patients with renal insufficiency. Antimicrob Agents ... Below are the most recent publications written about "Amdinocillin" by people in Profiles. ...
Amdinocillin | Article about amdinocillin by The Free Dictionary
Find out information about amdinocillin. any of a group of chemically similar substances obtained from molds of the genus ... Penicillium that were the first antibiotic antibiotic, any of a variety of... Explanation of amdinocillin ... Amdinocillin , Article about amdinocillin by The Free Dictionary https://encyclopedia2.thefreedictionary.com/amdinocillin ... redirected from amdinocillin). Also found in: Dictionary, Thesaurus, Medical. penicillin,. any of a group of chemically similar ...
Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...
... depending on the concentration of amdinocillin used during selection. Several genes have been demonstrated to give amdinocillin ... Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli. ... Amdinocillin (mecillinam) is a β-lactam antibiotic that is used mainly for the treatment of uncomplicated urinary tract ... Inactivation of the cysB gene and a resulting loss of cysteine biosynthesis are the major mechanism of amdinocillin resistance ...
Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales | Antimicrobial...
Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales. Frieder Fuchs, ... The activity of mecillinam (amdinocillin) was assessed in Enterobacterales (n = 420) isolated from urine samples between 2016 ... Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales ... Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales ...
Amdinocillin (Mecillinam) | Johns Hopkins ABX Guide
Amdinocillin (Mecillinam) answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, ... Amdinocillin (Mecillinam) is a topic covered in the Johns Hopkins ABX Guide. To view the entire topic, please sign in or ... "Amdinocillin (Mecillinam)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides ... Amdinocillin (Mecillinam) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2020 January 24 ...
Bupropion (Oral Route) Side Effects - Mayo Clinic
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset ...
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Bupropion (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Mecillinam - Wikipedia
Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds ... Neu HC (1985). "Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use". Pharmacotherapy. 5 (1 ... Pham P, Bartlett JG (August 28, 2008). "Amdinocillin (Mecillinam)". Point-of-Care Information Technology ABX Guide. Johns ...
Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027 - Space Market Research
Hospital pharmacy is spearheading the distribution channel segment for the amdinocillin market. Amdinocillin is penicillin ... Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027. [email protected] July 13, 2020. 0 ... Home/market research/Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027. market research. ... Amdinocillin has broad-spectrum activity against infections caused due to gram-negative bacteria. The oral bioavailability of ...
Role of the ftsA1p promoter in the resistance of mucoid mutants of Salmonella enterica to mecillinam: characterization of a new...
Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of...
Metabolism Shapes the Cell | Journal of Bacteriology
... treatment with amdinocillin results in rounded cells that lyse (25, 26). Amdinocillin resistance can be conferred by mutations ... One amdinocillin-resistant E. coli mutant that depends on SpoT but not RelA for resistance possesses a mutation in aroK. aroK ... Amdinocillin resistance.The close relationship between metabolism and cell elongation is illustrated by studies with mutants ... Amdinocillin (mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli. ...
Biofilms and Device-Associated Infections - Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC
Penicillin-binding protein 1A - DrugBank
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Systemic infections treated with amdinocillin in combination with other beta-lactam antibiotics. King, J.W., Beam, T.R., Neu, H ... Amdinocillin was safe and well tolerated and, in combination with other beta-lactam antibiotics, was effective in the treatment ... We report the results of a multicenter study evaluating the safety and efficacy of amdinocillin in combination with other beta- ...
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WikiGenes - Mecillinam - (2R,5R,6S)-6-(azepan-1-ylmethylideneamino)...
Study of the enhancement of beta-lactam activity by amdinocillin in a model of the human urinary bladder. Anderson, J.D., ... Amdinocillin: use alone or in combination with cefoxitin or carbenicillin-ticarcillin. Lawson, R.D., Estey, E.H., Bodey, G.P. ... Morphologic changes produced by amdinocillin alone and in combination with beta-lactam antibiotics: in vitro and in vivo. ... Amdinocillin plus cefoxitin versus cefoxitin alone in therapy of mixed soft tissue infections (including diabetic foot ...
Mecillinam9
- Amdinocillin (mecillinam) is a β-lactam antibiotic that is used mainly for the treatment of uncomplicated urinary tract infections. (asm.org)
- The activity of mecillinam (amdinocillin) was assessed in Enterobacterales ( n = 420) isolated from urine samples between 2016 and 2017. (asm.org)
- Amdinocillin (Mecillinam) is a topic covered in the Johns Hopkins ABX Guide . (hopkinsguides.com)
- Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria. (wikipedia.org)
- The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination with chlortetracycline. (wikipedia.org)
- Recently, Dan Andersson and colleagues from Uppsala University Sweden, published a truly unique and important study on the many mechanisms of mecillinam (aka amdinocillin) resistance in Escherichia coli . (asmblog.org)
- Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). (diva-portal.org)
- In vitro studies have shown a clear majority of ESBL E. coli to be susceptible to the beta-lactam antibiotic mecillinam (amdinocillin), but with an increased MIC compared to non-ESBL E. coli . (dovepress.com)
- Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. (pcure.se)
Pivoxil1
- 7 - 9 Several studies have shown oral prodrug pivmecillinam (pivoxil amdinocillin) to be a safe and effective agent in the treatment of UTI. (dovepress.com)
Penicillin4
- Amdinocillin: a novel penicillin. (wikipedia.org)
- Amdinocillin is penicillin antibiotic-associated with serious drug-related side effects such as skin rashes, nausea, vomiting, etc., hence hospital pharmacists adhere to accurate drug compounding in cognizance to physician's prescription. (spacemarketnow.com)
- However, amdinocillin, an agent that preferentially binds to the altered penicillin binding protein responsible for diminished penicillin susceptibility, has potential utility as a surrogate screening reagent for ampicillin resistance. (uthscsa.edu)
- We could alter the shape of Leptospira biflexa with the broad-spectrum β-lactam antibiotic penicillin G and with amdinocillin and aztreonam, which are β-lactams that preferentially target penicillin-binding protein 2 (PBP2) and PBP3, respectively, in some species. (pasteur.fr)
Urinary3
- The oral bioavailability of amdinocillin is very low hence its prodrug pivmecillinam is prescribed for treatment of urinary tract infection, typhoid, pyelonephritis, etc. (spacemarketnow.com)
- Urinary tract infections are leading the treatment segment for the amdinocillin market. (spacemarketnow.com)
- North America is anticipated to register rapid market growth during the forecast period because recently the USFDA has granted Qualified Infectious Disease Product (QIDP) designation to amdinocillin for the treatment of complicated urinary tract infection prevalence in the region. (spacemarketnow.com)
Escherichia1
- The objectives of this study were to identify mutations that confer amdinocillin resistance on laboratory-isolated mutants and clinical isolates of Escherichia coli and to determine why amdinocillin resistance remains rare clinically even though resistance is easily selected in the laboratory. (asm.org)
Resistance3
- Under laboratory selection, frequencies of mutation to amdinocillin resistance varied from 8 × 10 −8 to 2 × 10 −5 per cell, depending on the concentration of amdinocillin used during selection. (asm.org)
- Several genes have been demonstrated to give amdinocillin resistance, but here eight novel genes previously unknown to be involved in amdinocillin resistance were identified. (asm.org)
- Our results suggest that the frequency of mutation to amdinocillin resistance is high because of the large mutational target (at least 38 genes). (asm.org)
Pharmacokinetics1
- Pharmacokinetics of intravenous amdinocillin in healthy subjects and patients with renal insufficiency. (harvard.edu)
Efficacy1
- The other treatment segment is anticipated to be the fastest-growing segment in the near future on account of promising clinical trial studies pertaining to the therapeutic efficacy and safety of amdinocillin in the treatment of pyelonephritis. (spacemarketnow.com)
Gram-negative1
- Amdinocillin has broad-spectrum activity against infections caused due to gram-negative bacteria. (spacemarketnow.com)
Susceptibility1
- Collaborative clinical laboratory study of a broth-disk test for determination of bacterial susceptibility to beta-lactams in combination with amdinocillin. (asm.org)
Clinical1
- Furthermore, an affordable reimbursement scenario and proactive role adopted by the European Medical Agency (EMA) to evaluate the clinical trial investigation of amdinocillin prodrug in the treatment of pyelonephritis will accentuate the market growth in the region. (spacemarketnow.com)
MeSH1
- Amdinocillin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Agent1
- In in vitro and in vivo studies were used films to determine the interaction model of amdinocillin, an antiinflammatory agent, and sp1049c, a new hypocholesterolemic substance. (e-healthdiary.com)
Publication1
- This graph shows the total number of publications written about "Amdinocillin" by people in Harvard Catalyst Profiles by year, and whether "Amdinocillin" was a major or minor topic of these publication. (harvard.edu)
Active1
- It is active against gram-negative organisms and used as for amdinocillin. (pcure.se)
Target1
- Low levels indicative of streptomycin and amdinocillin may indicate that the patient relationship has not reached your target concentrations and stomata that there is insufficient drug present to be likewise effective. (e-healthdiary.com)