OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceHealth CareGeographicals
AmdinocillinAmdinocillin PivoxilSulfamethizoleEnterobacteriaceaeAnti-Bacterial AgentsMicrobial Sensitivity TestsSalmonella typhimuriumMutationEscherichia coliMolecular Sequence DataEscherichia coli ProteinsCellular PhoneBaltimorePenicillanic AcidAmbroxolDrug Information ServicesPamphletsDrug LabelingPatient Education as TopicFormularies as TopicDrug IndustryMedical Records Systems, ComputerizedBoliviaEcuadorBiotechnologyMoraceaeBrazilCaliforniaGenomicsalpha-MacroglobulinsPatents as TopicInventionsIntellectual PropertyHistory, 18th CenturyHistory, 17th Century
Amdinocillin
An amidinopenicillanic acid derivative with broad spectrum antibacterial action.
Amdinocillin Pivoxil
Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
Sulfamethizole
A sulfathiazole antibacterial agent.
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Salmonella typhimurium
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Escherichia coli Proteins
Proteins obtained from ESCHERICHIA COLI.
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Baltimore
Penicillanic Acid
A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)
Ambroxol
A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Drug Information Services
Services providing pharmaceutic and therapeutic drug information and consultation.
Pamphlets
Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Patient Education as Topic
The teaching or training of patients concerning their own health needs.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Drug Industry
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Medical Records Systems, Computerized
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
Bolivia
Ecuador
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Moraceae
The mulberry plant family of the order Urticales, subclass Hamamelidae, class Magnoliopsida. They have milky latex and small, petalless male or female flowers.
Brazil
California
Genomics
The systematic study of the complete DNA sequences (GENOME) of organisms.
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Patents as Topic
Exclusive legal rights or privileges applied to inventions, plants, etc.
Inventions
A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.
Intellectual Property
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
History, 18th Century
Time period from 1701 through 1800 of the common era.
History, 17th Century
Time period from 1601 through 1700 of the common era.

tRNA synthetase mutants of Escherichia coli K-12 are resistant to the gyrase inhibitor novobiocin. (1/94)

In previous studies we demonstrated that mutations in the genes cysB, cysE, and cls (nov) affect resistance of Escherichia coli to novobiocin (J. Rakonjac, M. Milic, and D. J. Savic, Mol. Gen. Genet. 228:307-311, 1991; R. Ivanisevic, M. Milic, D. Ajdic, J. Rakonjac, and D. J. Savic, J. Bacteriol. 177:1766-1771, 1995). In this work we expand this list with mutations in rpoN (the gene for RNA polymerase subunit sigma54) and the tRNA synthetase genes alaS, argS, ileS, and leuS. Similarly to resistance to the penicillin antibiotic mecillinam, resistance to novobiocin of tRNA synthetase mutants appears to depend upon the RelA-mediated stringent response. However, at this point the overlapping pathways of mecillinam and novobiocin resistance diverge. Under conditions of stringent response induction, either by the presence of tRNA synthetase mutations or by constitutive production of RelA protein, inactivation of the cls gene diminishes resistance to novobiocin but not to mecillinam.  (+info)

A Canadian national surveillance study of urinary tract isolates from outpatients: comparison of the activities of trimethoprim-sulfamethoxazole, ampicillin, mecillinam, nitrofurantoin, and ciprofloxacin. The Canadian Urinary Isolate Study Group. (2/94)

Ampicillin, trimethoprim-sulfamethoxazole, mecillinam, nitrofurantoin, and ciprofloxacin mean resistance rates for 2,000 urinary tract isolates collected from outpatients across Canada in 1998 were 41.1, 19.2, 14.7, 5.0, and 1.8%, respectively. For Escherichia coli isolates alone (n = 1,681) comparable rates were 41. 0, 18.9, 7.4, 0.1, and 1.2%, respectively. The majority of E. coli isolates resistant to ampicillin, trimethoprim-sulfamethoxazole, or ciprofloxacin were susceptible (MIC, <16 microg/ml) to mecillinam.  (+info)

Selected amplification of the cell division genes ftsQ-ftsA-ftsZ in Escherichia coli. (3/94)

Rapidly growing Escherichia coli is unable to divide in the presence of the antibiotic mecillinam, whose direct target is penicillin-binding protein 2 (PBP2), responsible for the elongation of the cylindrical portion of the cell wall. Division can be restored in the absence of PBP2 activity by increasing the concentration of the cell division proteins FtsQ, FtsA, and FtsZ. We tried to identify regulators of the ftsQ-ftsA-ftsZ operon among mecillinam-resistant mutants, which include strains overexpressing these genes. By insertional mutagenesis with mini-Tn10 elements, we selected for insertions that conferred mecillinam resistance. Among 15 such mutants, 7 suppressed the thermosensitivity of the ftsZ84(Ts) mutant, strongly suggesting that they had increased FtsZ activity. In all 7 cases, however, the mutants resulted from a duplication of the ftsQAZ region. These duplications seemed to result from multiple events, suggesting that no simple insertional inactivation can result in a mutant with sufficiently amplified ftsQAZ expression to confer mecillinam resistance. The structure of the duplications suggests a general method for constructing directed duplications of precise sequences.  (+info)

Affinities of beta-lactams for penicillin binding proteins of Chlamydia trachomatis and their antichlamydial activities. (4/94)

Binding affinities of beta-lactam antibiotics for the three penicillin binding proteins (PBPs) from Chlamydia trachomatis were determined in vitro and compared with their antichlamydial activities. Mecillinam selectively inhibited PBP1, with a 50% inhibitory concentration for PBP1 binding (0.2 microg/ml) similar to the MIC (0.1 microg/ml) and minimum bactericidal concentration (0.25 microg/ml). Although the other beta-lactams inhibited a wider range of PBPs than mecillinam, their antichlamydial activities were inferior to that of mecillinam.  (+info)

Constitutive septal murein synthesis in Escherichia coli with impaired activity of the morphogenetic proteins RodA and penicillin-binding protein 2. (5/94)

The pattern of peptidoglycan (murein) segregation in cells of Escherichia coli with impaired activity of the morphogenetic proteins penicillin-binding protein 2 and RodA has been investigated by the D-cysteine-biotin immunolabeling technique (M. A. de Pedro, J. C. Quintela, J.-V. Holtje, and H. Schwarz, J. Bacteriol. 179:2823-2834, 1997). Inactivation of these proteins either by amdinocillin treatment or by mutations in the corresponding genes, pbpA and rodA, respectively, leads to the generation of round, osmotically stable cells. In normal rod-shaped cells, new murein precursors are incorporated all over the lateral wall in a diffuse manner, being mixed up homogeneously with preexisting material, except during septation, when strictly localized murein synthesis occurs. In contrast, in rounded cells, incorporation of new precursors is apparently a zonal process, localized at positions at which division had previously taken place. Consequently, there is no mixing of new and old murein. Old murein is preserved for long periods of time in large, well-defined areas. We propose that the observed patterns are the result of a failure to switch off septal murein synthesis at the end of septation events. Furthermore, the segregation results confirm that round cells of rodA mutants do divide in alternate, perpendicular planes as previously proposed (K. J. Begg and W. D. Donachie, J. Bacteriol. 180:2564-2567, 1998).  (+info)

Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. (6/94)

Random screening for inhibitors of chromosome partitioning in Escherichia coli was done by the anucleate cell blue assay. A novel S-benzylisothiourea derivative, S-(3,4-dichlorobenzyl)isothiourea, tentatively named A22, was found to induce spherical cells and spherical anucleate cells in E. coli. Mecillinam, a specific inhibitor of penicillin-binding protein 2, which induces spherical cells in E. coli, also caused anucleate cell production. Spherical cells induced by treatment with either A22 or mecillinam varied in size, and anucleate cells seemed to be more frequent among the smaller cells. These results suggest that loss of the rod shape in E. coli leads to asymmetric cell division that results in production of anucleate cells. No competition was observed even in the presence of a 10-fold excess A22 in an in vitro assay of 14C-penicillin G binding, but mecillinam specifically inhibited binding of 14C-penicillin G to penicillin-binding protein 2. Simultaneous treatment with mecillinam and cephalexin, a specific inhibitor of penicillin-binding protein 3, induced lysis of E. coli cells, but a combination of A22 and cephalexin did not. These results suggest that the target molecule(s) of A22 was not penicillin-binding protein 2. A22 may act on a rod-shape-determining protein(s) other than penicillin-binding protein 2, such as RodA or MreB.  (+info)

Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. (7/94)

Resistance to antibiotics used for the treatment of urinary tract infections (UTIs) is increasing worldwide. The impact of in vitro resistance on clinical outcome in UTIs requires further study, since most studies of both humans and animals have evaluated only the efficacy of antibiotics toward bacteria susceptible in vitro. We were interested in evaluating the relationship between the in vitro antibacterial effect and the in vivo efficacy after antibiotic treatment. We simulated a natural ascending UTI by use of the ascending UTI mouse model and used Escherichia coli strains with various susceptibilities to amdinocillin (mecillinam) and sulfamethizole. Mice were treated for 3 days with antibiotic doses approximating human urinary tract concentrations after a standard oral dose. For a susceptible strain (MIC, 0.5 micro g/ml) and a resistant strain (MIC, 128 micro g/ml), respectively, there were significant reductions in bacterial counts in the urine, bladder, and kidneys after treatment with amdinocillin, whereas for a strain for which the MIC was 16 micro g/ml, there was a significant reduction in bacterial counts in the kidneys only (P < 0.05). Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys. For amdinocillin, there was no clear-cut relationship between the in vitro susceptibility and the in vivo outcome, while for sulfamethizole, we found a relationship between the MIC for the strain and the effect in the urinary tract.  (+info)

The pharmacokinetics of mecillinam and pivmecillinam in pregnant and non-pregnant women. (8/94)

1. The pharmacokinetics of parenteral mecillinam (n = 27) and oral pivmecillinam (n = 12) were studied in pregnant (n = 27) and non-pregnant (n = 12) subjects. 2. In early pregnancy (9-14 weeks of gestation) the mean peak plasma drug concentration (Cmax = 19 +/- 9 micrograms ml-1) after an intravenous injection of 200 mg mecillinam was significantly lower (P less than 0.05) and the volume of distribution (V = 49 +/- 20.1) significantly larger (P less than 0.05) than in non-pregnant subjects (Cmax = 35 +/- 18 micrograms ml-1, V = 29 +/- 12.1). In late pregnancy (39-40 weeks of gestation) the plasma mean peak concentration (Cmax = (29 +/- 14 micrograms ml-1) after parenteral administration of 200 mg mecillinam was slightly lower and the volume of distribution (V = 65 +/- 29.1, V = 0.9 +/- 0.4 l kg-1) significantly larger than that in non-pregnant subjects (V = 0.4 +/- 0.3 l kg-1). Also after oral administration of 200 mg pivmecillinam, equimolar to 136.5 mg mecillinam, the mean peak plasma concentration in pregnant subjects (Cmax = 1.8 +/- 1.2 micrograms ml-1) was slightly lower than that in non-pregnant subjects (Cmax = 1.7 +/- 1.2 micrograms ml-1). 3. The mean half-life of elimination after parenteral administration of mecillinam was significantly longer during both early (t1/2,Z = 133 +/- 38 min, P less than 0.05) and late pregnancy (t1/2,Z = 107 +/- 41 min, P less than 0.05) as compared with the non-pregnant state (t1/2,Z = 75 +/- 21 min).(ABSTRACT TRUNCATED AT 250 WORDS)  (+info)

Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...
Amd resistance is caused by cysB mutations that prevent production of cysteine.To confirm that the cysB mutations identified confer Amd resistance, several tests were performed. First, a cysB knockout mutation was constructed and introduced into laboratory strain MG1655. Inactivation of cysB conferred a Amdr phenotype where the cysB knockout mutant for which the MIC was 24 mg/liter (compared to 0.125 for the cysB+ strain), showing that inactivation of the CysB protein causes resistance. This had previously been shown in S. enterica serovar Typhimurium (31). Second, cysteine auxotrophy screening of some 40 Amdr E. coli strains originating from MG1655 in the initial selection of Amdr mutants was done with M9 glucose and M9 glucose-cysteine plates. One strain, DA24053, was a cysteine auxotroph. The cysB gene was PCR amplified and sequenced, showing that the strain had a deletion of bp 148 in cysB. The Amd MIC for this strain was 24 mg/liter, which is identical to that for the cysB knockout ...
https://aac.asm.org/content/59/3/1718?ijkey=fcb42f3aecaf2377ae7878b1eee978fdbacccb22&keytype2=tf_ipsecsha
Amdinocillin (Mecillinam) | Johns Hopkins ABX GuideAmdinocillin (Mecillinam) | Johns Hopkins ABX Guide
Amdinocillin (Mecillinam) answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540014/all/Amdinocillin__Mecillinam_?q=Amikacin
Penicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants. | Journal of BacteriologyPenicillin-binding protein 2 is essential in wild-type Escherichia coli but not in lov or cya mutants. | Journal of Bacteriology
Penicillin-binding protein 2 (PBP2), target of the beta-lactam mecillinam, is required for rod morphology and cell wall elongation in Escherichia coli. A new temperature-sensitive PBP2 allele and an in vitro-constructed insertion deletion allele were shown to be lethal in wild-type strains, establishing that the activity of this protein is essential. Mutations in the lov or cya genes, conferring mecillinam resistance, compensated for the deleterious effect of the absence of PBP2. The resulting double mutants grew as spheres. In a cya mutant lacking PBP2, the restoration of a Cya+ phenotype by addition of cyclic AMP caused lethality and a block in cell division. These results show that in wild-type cells, PBP2 is essential for growth and division. ...
https://jb.asm.org/content/171/6/3025
Mutations in Cell Elongation Genes mreB, mrdA and mrdB Suppress The Shape Defect of RodZ-Deficient Cells.Mutations in Cell Elongation Genes mreB, mrdA and mrdB Suppress The Shape Defect of RodZ-Deficient Cells.
RodZ interacts with MreB and both factors are required to maintain the rod shape of Escherichia coli. The assembly of MreB into filaments regulates the subcellular arrangement of a group of enzymes that synthesizes the peptidoglycan (PG) layer. Howev
http://www.biomedsearch.com/nih/Mutations-in-Cell-Elongation-Genes/23301723.html
Jual Kursi Roda MurahJual Kursi Roda Murah
Jual kursi roda lengkap dan resmi dengan harga yang terjangkau. Dapatkan harga kursi roda murah dan alat kesehatan lainnya di Medicalogy |✓ Pengiriman cepat ✓ Original
https://www.medicalogy.com/c/beli-kursi-roda?utm_source=homepage&utm_medium=category-box&utm_campaign=kursi_roda
Evolution of Antibiotic Resistance without Antibiotic Exposure | Antimicrobial Agents and ChemotherapyEvolution of Antibiotic Resistance without Antibiotic Exposure | Antimicrobial Agents and Chemotherapy
All of the 52 evolved populations (Fig. 1) were tested against 10 antibiotics from different classes, yielding 520 drug-population combinations. A substantial number of the lineages showed a significant increase (2 to ,32-fold) in their MIC of different antibiotic classes. Thus, decreased susceptibility was observed against three different antibiotics (erythromycin, rifampin, and streptomycin) in 10 E. coli populations and against three different antibiotics (erythromycin, fosfomycin, and amdinocillin) in 8 S. enterica populations (Fig. 2). In total, 3.5% (18/520) of all tested combinations showed decreased susceptibility, whereas only 0.6% (3/520) showed increased susceptibility (three E. coli populations had a 2.3-fold reduction in the MIC of erythromycin). In all populations with decreased susceptibility, the putative resistance mutations (see below) showed signatures of selection, as the mutations had either gone to near-fixation or reached high frequencies in the population.. In all ...
https://aac.asm.org/content/61/11/e01495-17
Positioning of chemosensory clusters in E. coli and its relation to cell division | The EMBO JournalPositioning of chemosensory clusters in E. coli and its relation to cell division | The EMBO Journal
Recent studies revealed a high degree of spatial organisation in bacterial cells, and positioning of the chemoreceptor clusters does not appear to be an exception. Lateral clusters are distributed along the cell body in a periodic manner, with the peak positions roughly corresponding to 1/8, 1/4, 3/8, 1/2, 5/8, 3/4, and 7/8 of the distance between polar regions. Such periodicity suggests an anchorage to some hypothetical structure, which is further supported by the apparent immobility of lateral clusters. Our results make it unlikely that this structure relies directly on either the Min septum positioning system or the MreB cytoskeleton, although cluster positioning was affected by a loss of the rod shape upon a long‐term treatment with the MreB inhibitor A22. At the current stage, we can only speculate about the nature of this structure. Many protein complexes in bacteria appear to localise along helical filaments, and it has been recently shown that receptors become inserted into the ...
http://emboj.embopress.org/content/26/6/1615
DNA: how to unravel the tangleDNA: how to unravel the tangle
A chromosome is rarely found in the shape we are used to seeing in biology books, that is to say the typical double rod shape. It is usually diluted in the nucleus and creates a bundle that under the microscope appears as a messy tangle. A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundles function.
https://www.nanowerk.com/news2/biotech/newsid=29791.php
Weblog OKU : Anything About Disabled People: Robot berkaki ganti kerusi roda (Berita Harian 26 April 2006)Weblog OKU : Anything About Disabled People: Robot berkaki ganti kerusi roda (Berita Harian 26 April 2006)
WL-16RIII beroperasi menggunakan sepasang kayu bedik. Bagaimanapun, Takanishi juga berharap untuk membangunkan sebuah model lain yang boleh berfungsi lebih bebas tanpa peralatan itu bagi membolehkan ia dijadikan pengganti kerusi roda dan memberi peluang kepada warga tua atau orang kurang upaya yang sukar menggunakan tangan atau lengan untuk terus menggunakan robot ...
http://ogos1992.blogspot.com/2006/06/robot-berkaki-ganti-kerusi-roda-berita.html
Ibuprofen versus mecillinam for uncomplicated cystitis - a randomized controlled trial study protocol - PublicationlistAAMIbuprofen versus mecillinam for uncomplicated cystitis - a randomized controlled trial study protocol - PublicationlistAAM
BackgroundAlthough uncomplicated cystitis is often self-limiting, most such patients will be prescribed antibiotic treatment. We are investigating whether treatment of cystitis with an NSAID is as effective as an antibiotic in achieving symptomatic resolution.Methods/DesignThis is a randomized, controlled, double blind trial following the principles of Good Clinical Practice. Women between the ages of 18 to 60 presenting with symptoms of uncomplicated cystitis are screened for eligibility. 500 women from four sites in Norway, Sweden and Denmark are allocated to treatment with 600 mg ibuprofen three times a day or 200 mg mecillinam three times a day for three days. Allocation is conducted using block randomization. The primary outcome is the number of patients who feel cured by day four as recorded in a diary. Adverse events will be handled and reported in accordance with Good Clinical Practice.DiscussionIf treatment of uncomplicated cystitis with ibuprofen is as effective as mecillinam for ...
https://publichealth.ku.dk/about-the-department/general/publications/publicationlistaam/?pure=en%2Fpublications%2Fibuprofen-versus-mecillinam-for-uncomplicated-cystitis--a-randomized-controlled-trial-study-protocol
How and why cells grow as rods | BMC Biology | Full TextHow and why cells grow as rods | BMC Biology | Full Text
The rod is a ubiquitous shape adopted by walled cells from diverse organisms ranging from bacteria to fungi to plants. Although rod-like shapes are found in cells of vastly different sizes and are constructed by diverse mechanisms, the geometric similarities among these shapes across kingdoms suggest that there are common evolutionary advantages, which may result from simple physical principles in combination with chemical and physiological constraints. Here, we review mechanisms of constructing rod-shaped cells and the bases of different biophysical models of morphogenesis, comparing and contrasting model organisms in different kingdoms. We then speculate on possible advantages of the rod shape, and suggest strategies for elucidating the relative importance of each of these advantages.
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-014-0054-8
Roda J.C. B.V. Company Profile | Kerkrade, LIMBURG, Netherlands | Competitors, Financials & Contacts - Dun & BradstreetRoda J.C. B.V. Company Profile | Kerkrade, LIMBURG, Netherlands | Competitors, Financials & Contacts - Dun & Bradstreet
Find company research, competitor information, contact details & financial data for Roda J.C. B.V. of Kerkrade, LIMBURG. Get the latest business insights from Dun & Bradstreet.
https://www.dnb.com/business-directory/company-profiles.roda_jc_bv.941229fce83e74f40c57ed999388890d.html
Paris to La Roda - 10 ways to travel via train, plane, bus, and carParis to La Roda - 10 ways to travel via train, plane, bus, and car
The cheapest way to get from Paris to La Roda costs only €85, and the quickest way takes just 8¼ hours. Find the travel option that best suits you.
https://www.rome2rio.com/s/Paris/La-Roda
Ferrari 458 Italia com rodas aro 20Ferrari 458 Italia com rodas aro 20
Carro: Ferrari 458 Italia Marca da Roda: Ferrari Modelo da Roda: - Aro: 20 Modelo Pneu: - Método de Rebaixamento: Suspensão Original Demais acessórios: - Cidade/Estado: - Fotos enviadas por : -
https://www.carrosdub.com.br/2013/01/17/ferrari-458/ferrari-458-italia-com-rodas-aro-20/
Chrysler 300c DUB com rodas aro 22Chrysler 300c DUB com rodas aro 22
Carro: Chrysler 300c Cor: Prata Marca da Roda: Kartier Forged Modelo da Roda: Carrera Aro: 22 Modelo Pneu: 235/30/R22 Método de Rebaixamento: Suspensão Fixa Demais acessórios: Xenon Cidade/Estado: Créditos: Kartier Forged
https://www.carrosdub.com.br/2013/05/09/300c/chrysler-300c-dub-com-rodas-aro-22/
WFMU: Strength Through Failure with Fabio: Playlist from April 7, 2011WFMU: Strength Through Failure with Fabio: Playlist from April 7, 2011
A few years ago the mekons played 3 nights of shows in New York to celebrate their 30th anniversary as a band. The 3 shows sold out quickly, and so they added a 4th show at the Mercury Lounge that started at 6 pm. They looked out on the big crowd, and one of them said from the stage, I see weve found the perfect time for our fans. Start at 6:00, and all of our fans can be home safely, tucked up in bed, by 9:00 ...
http://wfmu.org/playlists/shows/39861
Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized...Pivmecillinam versus sulfamethizole for short-term treatment of uncomplicated acute cystitis in general practice: a randomized...
Adolescent, Adult, Amdinocillin Pivoxil, Anti-Bacterial Agents, Anti-Infective Agents, Urinary, Cystitis, Drug Administration Schedule, Female, Humans, Middle Aged, Sulfamethizole, Treatment Outcome, Urinary Tract Infections, Young ...
https://publichealth.ku.dk/staff/?pure=en%2Fpublications%2Fpivmecillinam-versus-sulfamethizole-for-shortterm-treatment-of-uncomplicated-acute-cystitis-in-general-practice-a-randomized-controlled-trial
UC Davis Mathematics :: SeminarsUC Davis Mathematics :: Seminars
Despite decades of study, an understanding of how the peptidoglycan network is assembled with a robustly maintained micron-scale shape and size has remained elusive. In this work, we introduce a model of rod-shaped cell growth that we use to investigate the roles of spatial regulation of peptidoglycan synthesis, biochemical properties of glycan strands, and mechanical stretching during insertion. Our studies reveal that rod shape maintenance requires insertion to be insensitive to fluctuations in cell-wall density and stress, and that a helical pattern of insertion is sufficient for elongation without significant loss of shape. In addition, we present evidence that left-handed chirality of the cytoskeleton in Escherichia coli gives rise to a global, right-handed chiral ordering of the cell wall. Local, MreB-guided insertion of material into the peptidoglycan network naturally orders the glycan strands and causes cells to twist left-handedly during elongational growth. Through comparison with the ...
https://www.math.ucdavis.edu/research/seminars/?talk_id=3454
emb net slideshareemb net slideshare
People who take notes do not catch everything and its best to watch the video so that you get everything in context. Emb +pasa 1. Once your presentation is published online, its time to get the embed code so you can embed it into your WordPress post or website. De groep kinderen en (jong) volwassenen met een ernstige meervoudige beperking is moeilijk te beschrijven. Slideshare presentations can be embedded in EHQ as a Custom Widget, or in any feedback tool (forums, surveys, introductions, news, guestbook introductions, Q&A tools and stories). Wim Vanderbauwhede. MORPHOLOGY OF ESCHERICHIA COLI (E. COLI) Shape - Escherichia coli is a straight, rod shape (bacillus) bacterium.. Newsletter Signup . This time, the agar can differentiate fecal and non-fecal types of coli aerogenes group as well as salmonellae and other types of non-lactose fermenting organisms. You cannot modify either the home node or the current node of a node-scoped management LIF. Content can then be viewed on the site itself, on ...
https://picasso-project.eu/exports-of-noao/0711fc-emb-net-slideshare
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Growth and Cellular Differentiation of Myxococcus xanthus in the Presence of β-Lactam Antibiotics | Microbiology SocietyGrowth and Cellular Differentiation of Myxococcus xanthus in the Presence of β-Lactam Antibiotics | Microbiology Society
Summary: The effect of different β-lactam antibiotics on the growth and morphology of Myxococcus xanthus has been examined. Exposure to penicillin and cephalexin resulted in spheroplast and filament formation, respectively. Mecillinam appeared to inhibit cell elongation and caused the formation of bent cells with central bulges. Myxospore formation was inhibited by cephalexin but not by mecillinam, although myxospores formed in the presence of mecillinam showed defects after germination. Germination of myxospores involves substantial cell-wall turnover as measured by uptake and loss of meso-diamino[14C]pimelic acid. Although turnover was observed when myxospores were germinated in the presence of mecillinam, the bacteria remained as spheres. Growth of these germinated myxospores following removal of mecillinam indicated that wall material laid down during the early stages of germination is stable and a rod shape could be re-established only by bipolar growth of new wall.
https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-124-2-281
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Pediatric Rhabdomyosarcoma Workup: Laboratory Studies, Imaging Studies, ProceduresPediatric Rhabdomyosarcoma Workup: Laboratory Studies, Imaging Studies, Procedures
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Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. The name is derived from the Greek words rhabdo, which means rod shape, and myo, which means muscle.
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Distinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12 | PNASDistinct penicillin binding proteins involved in the division, elongation, and shape of Escherichia coli K12 | PNAS
The varied effects of beta-lactam antibiotics on cell division, cell elongation, and cell shape in E. coli are shown to be due to the presence of three essential penicillin binding proteins with distinct roles in these three processes. (A) Cell shape: beta-Lactams that specifically result in the production of ovoid cells bind to penicillin binding protein 2 (molecular weight 66,000). A mutant has been isolated that fails to bind beta-lactams to protein 2, and that grows as round cells. (B) Cell division: beta-Lactams that specifically inhibit cell division bind preferentially to penicillin binding protein 3 (molecular weight 60,000). A temperature-sensitive cell division mutant has been shown to have a thermolabile protein 3. (C) Cell elongation: One beta-lactam that preferentially inhibits cell elongation and causes cell lysis binds preferentially to binding protein 1 (molecular weight 91,000). Evidence is presented that penicillin bulge formation is due to the inhibition of proteins 2 and 3 in ...
https://www.pnas.org/content/72/8/2999?ijkey=daa86ffd3bdc3cccd652d09ca8b4519b3d7d3a70&keytype2=tf_ipsecsha
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Penicillin Binding Protein Animation - BioSolutionsPenicillin Binding Protein Animation - BioSolutions
Penicillin-binding proteins (PBPs) are a group of proteins that are characterized by their affinity for and binding of penicillin. They are a normal constitutent of many bacteria;All beta-lactam antibiotics bind to PBP to have their effect of preventing cell wall construction by the bacterium.
https://bioisolutions.blogspot.com/2008/12/penicillin-binding-protein-animation.html
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ChlortetracyclineChlortetracycline
The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination ...
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Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...
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https://aac.asm.org/content/59/3/1718?ijkey=fcb42f3aecaf2377ae7878b1eee978fdbacccb22&keytype2=tf_ipsecsha
Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales | Antimicrobial...Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales | Antimicrobial...
Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales. Frieder Fuchs, ... The activity of mecillinam (amdinocillin) was assessed in Enterobacterales (n = 420) isolated from urine samples between 2016 ... Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales ... Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales ...
https://aac.asm.org/content/63/4/e02402-18
Amdinocillin (Mecillinam) | Johns Hopkins ABX GuideAmdinocillin (Mecillinam) | Johns Hopkins ABX Guide
Amdinocillin (Mecillinam) answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, ... Amdinocillin (Mecillinam) is a topic covered in the Johns Hopkins ABX Guide. To view the entire topic, please sign in or ... "Amdinocillin (Mecillinam)." Johns Hopkins ABX Guide, The Johns Hopkins University, 2016. Johns Hopkins Guide, www.hopkinsguides ... Amdinocillin (Mecillinam) [Internet]. In: Johns Hopkins ABX Guide. The Johns Hopkins University; 2016. [cited 2020 January 24 ...
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540014/all/Amdinocillin__Mecillinam_?q=Amikacin
Bupropion (Oral Route) Side Effects - Mayo ClinicBupropion (Oral Route) Side Effects - Mayo Clinic
Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS). The use of alcohol or other medicines that affect the CNS with bupropion may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset ...
https://www.mayoclinic.org/drugs-supplements/bupropion-oral-route/side-effects/drg-20062478?p=1
Aplenzin Advanced Patient Information - Drugs.comAplenzin Advanced Patient Information - Drugs.com
Detailed drug Information for Aplenzin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
https://www.drugs.com/cons/aplenzin.html
Bupropion (Oral Route) Before Using - Mayo ClinicBupropion (Oral Route) Before Using - Mayo Clinic
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
https://www.mayoclinic.org/es-es/drugs-supplements/bupropion-oral-route/before-using/drg-20062478
Mecillinam - WikipediaMecillinam - Wikipedia
Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds ... Neu HC (1985). "Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use". Pharmacotherapy. 5 (1 ... Pham P, Bartlett JG (August 28, 2008). "Amdinocillin (Mecillinam)". Point-of-Care Information Technology ABX Guide. Johns ...
https://en.wikipedia.org/wiki/Mecillinam
Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027 - Space Market ResearchGlobal Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027 - Space Market Research
Hospital pharmacy is spearheading the distribution channel segment for the amdinocillin market. Amdinocillin is penicillin ... Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027. [email protected] July 13, 2020. 0 ... Home/market research/Global Amdinocillin Market Is Expected To Grow At A CAGR Of 3.0% From 2020 To 2027. market research. ... Amdinocillin has broad-spectrum activity against infections caused due to gram-negative bacteria. The oral bioavailability of ...
https://spacemarketnow.com/2020/07/13/global-amdinocillin-market-is-expected-to-grow-at-a-cagr-of-3-0-from-2020-to-2027/
Role of the ftsA1p promoter in the resistance of mucoid mutants of Salmonella enterica to mecillinam: characterization of a new...Role of the ftsA1p promoter in the resistance of mucoid mutants of Salmonella enterica to mecillinam: characterization of a new...
Amdinocillin / pharmacology* * Bacterial Proteins / genetics* * Bacterial Proteins / physiology * Cytoskeletal Proteins* * Drug ...
https://pubmed.ncbi.nlm.nih.gov/11425476/?dopt=Abstract
Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of...Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of...
Amdinocillin Pivoxil / administration & dosage* * Amdinocillin Pivoxil / adverse effects * Anti-Bacterial Agents / ...
https://pubmed.ncbi.nlm.nih.gov/17354160/?dopt=Abstract
Metabolism Shapes the Cell | Journal of BacteriologyMetabolism Shapes the Cell | Journal of Bacteriology
... treatment with amdinocillin results in rounded cells that lyse (25, 26). Amdinocillin resistance can be conferred by mutations ... One amdinocillin-resistant E. coli mutant that depends on SpoT but not RelA for resistance possesses a mutation in aroK. aroK ... Amdinocillin resistance.The close relationship between metabolism and cell elongation is illustrated by studies with mutants ... Amdinocillin (mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli. ...
https://jb.asm.org/content/199/11/e00039-17
Biofilms and Device-Associated Infections - Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDCBiofilms and Device-Associated Infections - Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC
Amdinocillin treatment of catheter-associated bacteriuria in rabbits. J Infect Dis. 1989;159:1065-72. DOIPubMed ... In a rabbit model, biofilms on Foley catheter surfaces were highly resistant to high levels of amdinocillin, a beta-lactam ...
https://wwwnc.cdc.gov/eid/article/7/2/70-0277_article
Penicillin-binding protein 1A - DrugBankPenicillin-binding protein 1A - DrugBank
Amdinocillin. investigational, withdrawn. yes. inhibitor. Details. DB01603. Meticillin. approved, investigational. yes. ...
https://www.drugbank.ca/bio_entities/BE0004290
Find publikationer - Aalborg Universitets forskningsportalFind publikationer - Aalborg Universitets forskningsportal
Khosiawan, Y., Nielsen, I. E., Do, N. A. D. & Yahya, B. N., 24 feb. 2016, Information Systems Architecture and Technology: Proceedings of 36th International Conference on Information Systems Architecture and Technology - ISAT 2015 - Part I. Borzemski, L., Grzech, A., Swiatek, J. & Wilimowska, Z. (red.). Karpacz: Springer, Bind 429. s. 29-40 12 s. (Advances in Intelligent Systems and Computing, Bind 429).. Publikation: Bidrag til bog/antologi/rapport/konference proceeding › Konferenceartikel i proceeding › Forskning › peer review ...
https://vbn.aau.dk/da/publications/?ordering=startDate&descending=false&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=&format=&page=3079
Antiinfectives | SCBT - Santa Cruz BiotechnologyAntiinfectives | SCBT - Santa Cruz Biotechnology
Amdinocillin An antibacterial compound 32887-01-7. sc-207277 1 g. $124.00 0 ...
https://www.scbt.com/zh/browse/antiinfectives/_/N-1uw5a5x
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...
Amdinocillin; Amdinocillin Pivoxil; Amicycline; Amifloxacin; Amifloxacin Mesylate; Amikacin; Amikacin Sulfate; Aminosalicylic ... amdinocillin, amdinocillin pivoxil, amoxicillin, bacampicillin, benzylpenicillinic acid, benzylpenicillin sodium, epicillin., ...
http://patents.com/us-9566348.html
CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties - Google...CA2704853C - Immune stimulatory oligoribonucleotide analogs containing modified oligophosphate moieties - Google...
Alamecin; Alexidine; Amdinocillin; Amdinocillin Pivoxil; Amicycline; Amifloxacin; Amifloxacin Mesylate; Amikacin; Amikacin ...
https://patents.google.com/patent/CA2704853C/en
Yourassowsky E[au] - PubMed - NCBIYourassowsky E[au] - PubMed - NCBI
Protective effect of amdinocillin against emergence of resistance to ceftazidime in Enterobacter cloacae. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Yourassowsky+E%5Bau%5D&dispmax=50
Hoffmann La Roche Inc Product News and Research | CureHunterHoffmann La Roche Inc Product News and Research | CureHunter
Coactin - injectable, injection (500mg/vial) - Amdinocillin (Mecillinam) * Copegus - tablet, oral (400mg) Copegus Tablets - ...
http://www.curehunter.com/public/fdaFirmSearch000004-Hoffmann-La-Roche-Inc.do
Salmonella typhi (Typhoid Fever) and S. paratyphi (Paratyphoid Fever)Salmonella typhi (Typhoid Fever) and S. paratyphi (Paratyphoid Fever)
Mecillinam (Amdinocillin) Mecillinam is available either as the parenteral formulation or as a pro-drug, pivmecillinam for oral ...
http://www.antimicrobe.org/b106.asp
Chlortetracycline - WikipediaChlortetracycline - Wikipedia
The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination ...
https://en.wikipedia.org/wiki/Chlortetracycline
Human-Associated Extended-Spectrum β-Lactamase in the Antarctic | Applied and Environmental MicrobiologyHuman-Associated Extended-Spectrum β-Lactamase in the Antarctic | Applied and Environmental Microbiology
... and amdinocillin, 10 μg/disk (all antibiotics from Oxoid Ltd., Cambridge, United Kingdom). The E. coli strain ATCC 25922 was ...
https://aem.asm.org/content/78/6/2056
Rod Shape Determination by the Bacillus subtilis Class B Penicillin-Binding Proteins Encoded by pbpA and pbpH | Journal of...Rod Shape Determination by the Bacillus subtilis Class B Penicillin-Binding Proteins Encoded by pbpA and pbpH | Journal of...
The pbpA mutant also showed increased sensitivity to cephalexin, amdinocillin, and piperacillin, while the pbpC mutant did not ...
https://jb.asm.org/content/185/16/4717?ijkey=a6423568aa35b4672f463f8fa235eb125af36044&keytype2=tf_ipsecsha
WikiGenes - Gram-Negative Bacterial InfectionsWikiGenes - Gram-Negative Bacterial Infections
Systemic infections treated with amdinocillin in combination with other beta-lactam antibiotics. King, J.W., Beam, T.R., Neu, H ... Amdinocillin was safe and well tolerated and, in combination with other beta-lactam antibiotics, was effective in the treatment ... We report the results of a multicenter study evaluating the safety and efficacy of amdinocillin in combination with other beta- ...
https://www.wikigenes.org/e/mesh/e/10955.html
Emil Lin | UCSF ProfilesEmil Lin | UCSF Profiles
Amdinocillin pharmacokinetics. Simultaneous administration with cephalothin and cerebrospinal fluid penetration. Am J Med. 1983 ... Multiple-dose pharmacokinetics of amdinocillin in healthy volunteers. Antimicrob Agents Chemother. 1982 Jan; 21(1):54-7. PMID: ...
http://profiles.ucsf.edu/emil.lin
WikiGenes - Mecillinam - (2R,5R,6S)-6-(azepan-1-ylmethylideneamino)...WikiGenes - Mecillinam - (2R,5R,6S)-6-(azepan-1-ylmethylideneamino)...
Study of the enhancement of beta-lactam activity by amdinocillin in a model of the human urinary bladder. Anderson, J.D., ... Amdinocillin: use alone or in combination with cefoxitin or carbenicillin-ticarcillin. Lawson, R.D., Estey, E.H., Bodey, G.P. ... Morphologic changes produced by amdinocillin alone and in combination with beta-lactam antibiotics: in vitro and in vivo. ... Amdinocillin plus cefoxitin versus cefoxitin alone in therapy of mixed soft tissue infections (including diabetic foot ...
https://www.wikigenes.org/e/chem/e/36273.html
Table of Contents | Journal of Clinical MicrobiologyTable of Contents | Journal of Clinical Microbiology
... study of a broth-disk test for determination of bacterial susceptibility to beta-lactams in combination with amdinocillin. H D ...
https://jcm.asm.org/content/25/7
MecillinamPivoxilPenicillinUrinaryEscherichiaResistancePharmacokineticsEfficacyGram-negativeSusceptibilityClinicalMeSHAgentPublicationActiveTarget
Mecillinam9
  • Amdinocillin (mecillinam) is a β-lactam antibiotic that is used mainly for the treatment of uncomplicated urinary tract infections. (asm.org)
  • The activity of mecillinam (amdinocillin) was assessed in Enterobacterales ( n = 420) isolated from urine samples between 2016 and 2017. (asm.org)
  • Amdinocillin (Mecillinam) is a topic covered in the Johns Hopkins ABX Guide . (hopkinsguides.com)
  • Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria. (wikipedia.org)
  • The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination with chlortetracycline. (wikipedia.org)
  • Recently, Dan Andersson and colleagues from Uppsala University Sweden, published a truly unique and important study on the many mechanisms of mecillinam (aka amdinocillin) resistance in Escherichia coli . (asmblog.org)
  • Mecillinam (amdinocillin) is a β-lactam antibiotic used to treat uncomplicated urinary tract infections (UTIs). (diva-portal.org)
  • In vitro studies have shown a clear majority of ESBL E. coli to be susceptible to the beta-lactam antibiotic mecillinam (amdinocillin), but with an increased MIC compared to non-ESBL E. coli . (dovepress.com)
  • Pivmecillinam is a mecillinam prodrug, a pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. (pcure.se)
Pivoxil1
  • 7 - 9 Several studies have shown oral prodrug pivmecillinam (pivoxil amdinocillin) to be a safe and effective agent in the treatment of UTI. (dovepress.com)
Penicillin4
  • Amdinocillin: a novel penicillin. (wikipedia.org)
  • Amdinocillin is penicillin antibiotic-associated with serious drug-related side effects such as skin rashes, nausea, vomiting, etc., hence hospital pharmacists adhere to accurate drug compounding in cognizance to physician's prescription. (spacemarketnow.com)
  • However, amdinocillin, an agent that preferentially binds to the altered penicillin binding protein responsible for diminished penicillin susceptibility, has potential utility as a surrogate screening reagent for ampicillin resistance. (uthscsa.edu)
  • We could alter the shape of Leptospira biflexa with the broad-spectrum β-lactam antibiotic penicillin G and with amdinocillin and aztreonam, which are β-lactams that preferentially target penicillin-binding protein 2 (PBP2) and PBP3, respectively, in some species. (pasteur.fr)
Urinary3
  • The oral bioavailability of amdinocillin is very low hence its prodrug pivmecillinam is prescribed for treatment of urinary tract infection, typhoid, pyelonephritis, etc. (spacemarketnow.com)
  • Urinary tract infections are leading the treatment segment for the amdinocillin market. (spacemarketnow.com)
  • North America is anticipated to register rapid market growth during the forecast period because recently the USFDA has granted Qualified Infectious Disease Product (QIDP) designation to amdinocillin for the treatment of complicated urinary tract infection prevalence in the region. (spacemarketnow.com)
Escherichia1
  • The objectives of this study were to identify mutations that confer amdinocillin resistance on laboratory-isolated mutants and clinical isolates of Escherichia coli and to determine why amdinocillin resistance remains rare clinically even though resistance is easily selected in the laboratory. (asm.org)
Resistance3
  • Under laboratory selection, frequencies of mutation to amdinocillin resistance varied from 8 × 10 −8 to 2 × 10 −5 per cell, depending on the concentration of amdinocillin used during selection. (asm.org)
  • Several genes have been demonstrated to give amdinocillin resistance, but here eight novel genes previously unknown to be involved in amdinocillin resistance were identified. (asm.org)
  • Our results suggest that the frequency of mutation to amdinocillin resistance is high because of the large mutational target (at least 38 genes). (asm.org)
Pharmacokinetics1
  • Pharmacokinetics of intravenous amdinocillin in healthy subjects and patients with renal insufficiency. (harvard.edu)
Efficacy1
  • The other treatment segment is anticipated to be the fastest-growing segment in the near future on account of promising clinical trial studies pertaining to the therapeutic efficacy and safety of amdinocillin in the treatment of pyelonephritis. (spacemarketnow.com)
Gram-negative1
  • Amdinocillin has broad-spectrum activity against infections caused due to gram-negative bacteria. (spacemarketnow.com)
Susceptibility1
  • Collaborative clinical laboratory study of a broth-disk test for determination of bacterial susceptibility to beta-lactams in combination with amdinocillin. (asm.org)
Clinical1
  • Furthermore, an affordable reimbursement scenario and proactive role adopted by the European Medical Agency (EMA) to evaluate the clinical trial investigation of amdinocillin prodrug in the treatment of pyelonephritis will accentuate the market growth in the region. (spacemarketnow.com)
MeSH1
  • Amdinocillin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Agent1
  • In in vitro and in vivo studies were used films to determine the interaction model of amdinocillin, an antiinflammatory agent, and sp1049c, a new hypocholesterolemic substance. (e-healthdiary.com)
Publication1
  • This graph shows the total number of publications written about "Amdinocillin" by people in Harvard Catalyst Profiles by year, and whether "Amdinocillin" was a major or minor topic of these publication. (harvard.edu)
Active1
  • It is active against gram-negative organisms and used as for amdinocillin. (pcure.se)
Target1
  • Low levels indicative of streptomycin and amdinocillin may indicate that the patient relationship has not reached your target concentrations and stomata that there is insufficient drug present to be likewise effective. (e-healthdiary.com)
Bupropion (Oral Route) Before Using - Mayo Clinic
Bupropion (Oral Route) Before Using - Mayo Clinic (mayoclinic.org)
Aricept Advanced Patient Information - Drugs.com
Aricept Advanced Patient Information - Drugs.com (drugs.com)
Metabolism Shapes the Cell | Journal of Bacteriology
Metabolism Shapes the Cell | Journal of Bacteriology (jb.asm.org)
Biofilms and Device-Associated Infections - Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC
Biofilms and Device-Associated Infections - Volume 7, Number 2-April 2001 - Emerging Infectious Diseases journal - CDC (wwwnc.cdc.gov)
Amdinocillin | Harvard Catalyst Profiles | Harvard Catalyst
Amdinocillin | Harvard Catalyst Profiles | Harvard Catalyst (connects.catalyst.harvard.edu)
Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |...
Amdinocillin (Mecillinam) Resistance Mutations in Clinical Isolates and Laboratory-Selected Mutants of Escherichia coli |... (aac.asm.org)
Human-Associated Extended-Spectrum β-Lactamase in the Antarctic | Applied and Environmental Microbiology
Human-Associated Extended-Spectrum β-Lactamase in the Antarctic | Applied and Environmental Microbiology (aem.asm.org)
WikiGenes - Gram-Negative Bacterial Infections
WikiGenes - Gram-Negative Bacterial Infections (wikigenes.org)
Table of Contents | Journal of Clinical Microbiology
Table of Contents | Journal of Clinical Microbiology (jcm.asm.org)
In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against...
In Vitro and In Vivo Activities of β-Lactams in Combination with the Novel β-Lactam Enhancers Zidebactam and WCK 5153 against... (aac.asm.org)
Small Things Considered: When Antibiotic Resistance in vitro Does Not Tell You What You Need To Know
Small Things Considered: When Antibiotic Resistance in vitro Does Not Tell You What You Need To Know (schaechter.asmblog.org)
Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine.
Reversion of High-level Mecillinam Resistance to Susceptibility in Escherichia coli During Growth in Urine. (uu.diva-portal.org)
Use of Thymine Limitation and Thymine Starvation To Study Bacterial Physiology and Cytology | Journal of Bacteriology
Use of Thymine Limitation and Thymine Starvation To Study Bacterial Physiology and Cytology | Journal of Bacteriology (jb.asm.org)
Robert E Black - Research Output - Johns Hopkins University
Robert E Black - Research Output - Johns Hopkins University (jhu.pure.elsevier.com)
Setting and Revising Antibacterial Susceptibility Breakpoints | Clinical Microbiology Reviews
Setting and Revising Antibacterial Susceptibility Breakpoints | Clinical Microbiology Reviews (cmr.asm.org)
Amdinocillin (Mecillinam) | Johns Hopkins ABX Guide
Amdinocillin (Mecillinam) | Johns Hopkins ABX Guide (hopkinsguides.com)
WHO EMRO | Shigella dysentery and shigella infections | Volume 2, issue 1 | EMHJ volume 2, 1996
WHO EMRO | Shigella dysentery and shigella infections | Volume 2, issue 1 | EMHJ volume 2, 1996 (emro.who.int)
Bacterial Cell Wall Synthesis: New Insights from Localization Studies | Microbiology and Molecular Biology Reviews
Bacterial Cell Wall Synthesis: New Insights from Localization Studies | Microbiology and Molecular Biology Reviews (mmbr.asm.org)
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com
Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.com (patents.com)
Pivmecillinam for infection - Selexid. Antibiotics, information | Patient - high-kick.ru
Pivmecillinam for infection - Selexid. Antibiotics, information | Patient - high-kick.ru (high-kick.ru)
Permanent Magnets Market Outlook - Curious Market Reports
Permanent Magnets Market Outlook - Curious Market Reports (curiousdesk.com)
Market Outlook - Space Market Research
Market Outlook - Space Market Research (spacemarketnow.com)
Code of Federal Regulations: Containing a Codification of Documents of ... - Google gr matas
Code of Federal Regulations: Containing a Codification of Documents of ... - Google gr matas (books.google.lv)