Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Expectorants: Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)Guaifenesin: An expectorant that also has some muscle relaxing action. It is used in many cough preparations.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Pleurodynia, Epidemic: An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.Irritable Bowel Syndrome: A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.Encephalomyelitis: A general term indicating inflammation of the BRAIN and SPINAL CORD, often used to indicate an infectious process, but also applicable to a variety of autoimmune and toxic-metabolic conditions. There is significant overlap regarding the usage of this term and ENCEPHALITIS in the literature.Bromine: A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Sodium Channels: Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.Complex Regional Pain Syndromes: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Respiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Positive-Pressure Respiration: A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.Syndrome: A characteristic symptom complex.Steroids: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)Infant, Newborn: An infant during the first month after birth.Chromatography, Reverse-Phase: A chromatography technique in which the stationary phase is composed of a non-polar substance with a polar mobile phase, in contrast to normal-phase chromatography in which the stationary phase is a polar substance with a non-polar mobile phase.Pseudoephedrine: A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Ephedrine: A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.Nasal Decongestants: Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Pharmacies: Facilities for the preparation and dispensing of drugs.Drug and Narcotic Control: Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.

Transferability of cephalothin to the alveolar cavity in thoroughbreds. (1/26)

Five Thoroughbreds were classified into 4 groups according to the administration method used for saline solution (saline), ambroxol, and cephalothin sodium (cephalothin). In group A, cephalothin was injected intravenously after oral administration of ambroxol. In group B, cephalothin was injected intravenously after oral administration of saline. Groups C and D were used as control groups. The dose of cephalothin or ambroxol was clinically administrated. Venous blood and bronchoalveolar lavage fluid (BALF) were sampled from each group. In groups A and B, cephalothin concentrations in plasma reached their maximum level 5 min after cephalothin administration and then declined over time. In plasma obtained from groups A and B, there were no significant differences in pharmacokinetic parameters (T1/2, Kel, Vd). By contrast, cephalothin concentrations in BALF reached their peak at 180 min after cephalothin administration in both groups A and B and maintained a relatively high level even after 300 min. These findings indicate that cephalothin requires a relatively long period of time to move from the blood stream to the alveolar cavity, but once transferred to the alveolar cavity, it is preserved for a long time. In groups A and B, cephalothin concentrations in BALF were approximately at the same level. However, in group A, total protein in BALF was lower at 60, 180, and 300 min than the other groups. Then, cephalothin concentration was adjusted to total protein in BALF. After adjustment to total protein in BALF, group A showed a concentration level of cephalothin approximately 1.5-fold higher than that of group B. This suggests that the transferability of cephalothin to the alveolar cavity improves as a result of the oral administration of ambroxol.  (+info)

Effect of early ambroxol treatment on lung functions in mechanically ventilated preterm newborns who subsequently developed a bronchopulmonary dysplasia (BPD). (2/26)

In a randomized trial in 102 preterm newborns with respiratory distress syndrome (RDS) it has been shown that early Ambroxol treatment (30 mg kg(-1) over the first 5 days) significantly reduces the incidence of RDS-associated complications [bronchopulmonary dysplasia (BPD), intraventricular haemorrhage, post-natal acquired pneumonia]. The aim of the present analysis was to investigate the effect of Ambroxol treatment on lung function in newborns who developed BPD. Respiratory function testing (RFT) was performed immediately after extubation and at day 28. Tidal volume (VT) and respiratory frequency (f) were measured during tidal breathing using the deadspace free flow-through technique. The lung mechanic parameter VT/maxPes was determined by measuring the maximal oesophageal pressure changes, maxPes, with a catheter tip pressure transducer. In the placebo group 36/50 infants were extubated within the first 28 days of life and 13/36 (36%) developed BPD. In the Ambroxol group 44/52 were extubated and 9/44 (20%) developed BPD. After extubation, RFT showed (i) no statistically significant difference in the ventilatory parameters of either treatment group, (ii) improved (P<0.05) lung mechanics (VT/maxPes) in Ambroxol group compared to controls (94+/-27 ml kPa(-1) vs. 8.1+/-2.6 ml kPa(-1)) and (iii) no statistically significant difference in lung function between infants with and without BPD. At day 28 we found (i) no effect of early Ambroxol treatment on lung functions, (ii) significantly (P < 0.05) higher f (58.5+/-11.7 min(-1) vs. 49.7+/-10.1 min(-1)) and significantly (P<0.01) lower V(T) (9.6+/-1.9 ml vs. 12.3+/-2.7 ml) and V(T)/maxPes (8.9+/-2.6 ml kPa(-1)] vs. 12.0+/-2.9 ml kPa(-1)) in infants with BPD compared to infants without and (iii) these differences are not influenced by early Ambroxol treatment. If the process of BPD development is induced, early Ambroxol treatment has no influence on impaired lung function at day 28.  (+info)

Effects of N-acetylcysteine and ambroxol on the production of IL-12 and IL-10 in human alveolar macrophages. (3/26)

BACKGROUND: N-acetylcysteine (NAC) and ambroxol (AMB) have recently been proposed as possible therapeutic agents in the treatment of pulmonary disorders. IL-12 plays an important role in host resistance to infection and the development of Th-1 cells. In contrast, IL-10 is involved in anti-inflammatory and immunoregulatory mechanisms. OBJECTIVE: We investigated the effects of NAC and AMB on secretions of IL-12 and IL-10 from human alveolar macrophages. METHODS: Alveolar macrophages were obtained from 7 healthy nonsmokers by bronchoalveolar lavage. The cells were first incubated with either NAC or AMB for 2 h and then cultured in lipopolysaccharide (LPS) solution for 24 h. IL-12 and IL-10 secretions were measured by ELISA. RESULT: Both NAC and AMB enhanced LPS-induced secretion of IL-12. NAC also enhanced LPS-induced IL-10 secretion, while AMB did not. The ratio IL-12/IL-10 secretion was increased by AMB, but NAC did not affect it. CONCLUSIONS: The results suggest that NAC enhances inflammatory and immune responses and prevents excessive responses reciprocally, through keeping local balance of IL-12 and IL-10 production in alveolar macrophages at inflammatory sites of bacterial pneumonia. AMB appears to strengthen inflammatory responses and cell-mediated immunity, facilitating the development of Th-1 cells, through shifting the local balance to IL-12 dominance.  (+info)

Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro. (4/26)

The present study examined the effect of ambroxol on free radical production, granule enzyme release, and cell death in silica-activated rat alveolar macrophages. The action of ambroxol was assayed by measuring changes in the activities of protein kinase C (PKC) and tyrosine kinase (PTK) and in the intracellular calcium level. Ambroxol attenuated the production of superoxide, hydrogen peroxide, and nitric oxide and the release of acid phosphatase and lysozyme in macrophages activated by silica. Staurosporine, genistein, EGTA, and trifluoperazine inhibited the silica-induced free radical production and granule enzyme release. Silica induced the increase in PKC and PTK activities and the elevation of intracellular calcium level in macrophages, which was decreased by ambroxol. Silica induced a cell death and increased the caspase-3 activity in macrophages in a concentration-dependent manner. Ambroxol decreased the silica-induced cell viability loss in macrophages. The results show that ambroxol decreases the stimulated responses and cell death in rat alveolar macrophages exposed to silica, which may be accomplished by inhibition of activation processes, protein kinases, and calcium transport. The inhibitory effect of ambroxol on silica-induced cell death appears to provide the protective effect on pulmonary tissues against the toxic action of silica.  (+info)

Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. (5/26)

The protective effect of ambroxol, a mucolytic agent which has antioxidant properties and stimulates the release of pulmonary surfactant, against influenza-virus proliferation in the airway was investigated in mice. Ambroxol or the vehicle was administered intraperitoneally twice a day for 5-7 days to mice shortly after intranasal infection with a lethal dose of influenza A/Aichi/68 (H3N2) virus, and the survival rate, virus titre and levels of factors regulating virus proliferation in the airway fluid were analysed. Ambroxol significantly suppressed virus multiplication and improved the survival rate of mice. The effect of ambroxol reached a peak at 10 mg x kg(-1) x day(-1), higher doses being less effective. Ambroxol stimulated the release of suppressors of influenza-virus multiplication, such as pulmonary surfactant, mucus protease inhibitor, immunoglobulin (Ig)-A and IgG, although it stimulated the release of a trypsin-type protease that potentiates virus proliferation. In addition, ambroxol transiently suppressed release of the cytokines, tumour necrosis factor-alpha, interferon-gamma and interleukin-12, into airway fluid. Although ambroxol had several negative effects on the host defence system, overall it strikingly increased the concentrations of suppressors of influenza-virus multiplication in the airway.  (+info)

Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. (6/26)

Ambroxol has a long history for the treatment of airway diseases because of its beneficial effects on surfactant synthesis and mucus-modifying properties. Some findings, however, point to an additional effect on neuronal signal transduction: ambroxol can suppress reflexes such as the cough or the corneal reflex. The airways and the cornea are innervated by C-fibers, which express voltage-gated Na(+) channels with and without sensitivity to tetrodotoxin (TTX). In this study, we performed voltage-clamp experiments to investigate whether ambroxol affects these channel types. In rat dorsal root ganglia, TTX-resistant Na(+) currents were suppressed in a concentration-dependent manner with IC(50) values of 35.2 and 22.5 microM for tonic and phasic block, respectively. Depolarizing prepulses increased the potency of ambroxol, and steady-state inhibition curves were shifted to more negative values. The inhibition was not frequency-dependent. TTX-sensitive currents were inhibited with lower potency (approximately 50% inhibition with 100 microM). Recombinant rat brain IIA channels in Chinese hamster ovary cells were blocked with IC(50) values of 111.5 and 57.6 microM for tonic and phasic block, respectively; in contrast to TTX-resistant channels the block was frequency-dependent. Thus, ambroxol indeed blocks neuronal voltage-gated Na(+) channels, and TTX-resistant channels in sensory neurons were more sensitive than TTX-sensitive. Compared with known local anesthetics (e.g., lidocaine or benzocaine), the potency for Na(+) channel block was relatively high. A recent clinical trial has further confirmed that ambroxol relieved pain and was beneficial in patients who suffered from sore throat.  (+info)

Pulmonary alveolar proteinosis successfully treated with ambroxol. (7/26)

A 79-year-old woman was admitted to hospital due to a four-month history of a cough and dyspnea on exertion. Chest CT scans revealed ground glass opacity with thickened interlobular septa in both lungs. Bronchoalveolar lavage fluid (BALF) had milky appearance and revealed large acellular eosinophilic amorphous bodies positively stained with periodic acid-Schiff (PAS). Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) were present in sera and BALF from the patient. Ambroxol was started in a daily dose of 45 mg orally. Her oxygen saturation improved and abnormal shadows in CT scan disappeared 6 months after beginning the therapy.  (+info)

In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. (8/26)

Neutrophils are major culprits for the protease/antiprotease imbalance during various lung diseases, that is, chronic obstructive pulmonary disease, cystic fibrosis, idiopathic pulmonary fibrosis and adult respiratory distress syndrome. Thus, these cells are presently considered an ideal target for the pharmacologic control of tissue injury during these diseases. This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event. Ambroxol inhibited the production of superoxide anion by activated neutrophils, whereas bromhexine had no inhibitory effect. Ambroxol decreased the production of hypochlorous acid (HOCl) from activated neutrophils with high efficiency, whereas bromhexine had a modest activity. Ambroxol and bromhexine were capable of limiting the chlorination of monochlorodimedon by HOCl, displaying the capacity of directly scavenging the oxidant. Ambroxol decreased the release of elastase and myeloperoxidase from activated neutrophils, whereas bromhexine was ineffective. Ambroxol prevented the A1AT inactivation by neutrophils, whereas bromhexine was completely ineffective. Among drugs currently available for in vivo use in humans, ambroxol is unique by virtue of its ability to prevent neutrophil-mediated A1AT inactivation via inhibition of HOCl production as well as HOCl scavenging. Also taking into account its capacity for curbing elastase release, the drug displays the potential to lessen the burden of oxidants/proteases and to increase the antiprotease shield at the site of inflammation. Thus, ambroxol appears to be a good candidate for raising attempts to develop new therapeutic histoprotective approaches to inflammatory bronchopulmonary diseases.  (+info)

*Ambroxol

... is also anti-inflammatory, reducing redness in a sore throat. Ambroxol has recently been shown to increase activity of ... Ambroxol is often administered as an active ingredient in cough syrup. Ambroxol is indicated as "secretolytic therapy in ... Ambroxol also provides pain relief in acute sore throat. Pain in sore throat is the hallmark of acute pharyngitis. Sore throat ... Ambroxol is a potent inhibitor of the neuronal Na+ channels. This property led to the development of a lozenge containing 20 mg ...

*Lysosome

Ambroxol is a lysosomotropic drug of clinical use to treat conditions of productive cough for its mucolytic action. Ambroxol ... "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell ... Presumably for this reason, Ambroxol was also found to improve cellular function in some disease of lysosomal origin such as ... "Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells". Brain. 137 (5): 1481- ...

*Lysosomal storage disease

Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase, so it may be a useful ... Ambroxol triggers the secretion of lysosomes from cells by inducing a pH-dependent calcium release from acidic calcium stores. ... "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell ... "Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells". Brain. 137 (5): 1481- ...

*Van Andel Institute

LCT has supported trials in ambroxol, exenatide, simvastatin, liraglutide and others. A month later, in October, the Institute ...

*Bromhexine

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin. Broncholyte Elixir Bisolvon Paxirasol ...

*Aquaporin 3

2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells". Respiratory physiology & ...

*Myrtol standardized

Cefuroxime and ambroxol". Arzneimittel-Forschung. 50 (8): 700-11. doi:10.1055/s-0031-1300276. PMID 10994153. ...

*Calcium channel opener

In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal ... "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell ...

*Loratadine

... ambroxol, salbutamol, phenylephrine, and dexamethasone. The marketing of the Claritin brand is important in the history of ...

*Mucokinetics

... ambroxol, carbocisteine, erdosteine, mecysteine, and dornase alfa (some brand names are listed in the related articles). Adams ...

*List of MeSH codes (D02)

... ambroxol MeSH D02.092.146.290 --- benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide MeSH ... ambroxol MeSH D02.092.471.200 --- cystamine MeSH D02.092.471.245 --- dibenzylchlorethamine MeSH D02.092.471.302 --- ...

*ATC code R05

Cineole R05CB01 Acetylcysteine R05CB02 Bromhexine R05CB03 Carbocisteine R05CB04 Eprazinone R05CB05 Mesna R05CB06 Ambroxol ...

*Boehringer Ingelheim

... ambroxol) Pharmaton (standardized ginseng extract, vitamins, minerals, trace elements) Silomat(dextromethorphan) Thomapyrin ( ...

*List of drugs: Am

... ambroxol (INN) ambruticin (INN) ambucaine (INN) ambucetamide (INN) ambuside (INN) Amcill amcinafal (INN) amcinafide (INN) ...
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Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis Mostafa Yakoot1, Amel Salem2, Abdel-Mohsen Omar31Green Clinics and Research Center, Alexandria, Egypt; 2Al-Mabarah Hospital, 3Faculty of Pharmacy, Alexandria University, Alexandria, EgyptBackground: Acute exacerbations of chronic bronchitis (AECB) are defined as recurrent attacks of worsening bronchial inflammation that are marked by an increase in the volume of daily sputum produced, a change in color of the expectorated sputum, and worsening dyspnea. Farcosolvin® (Pharco Pharmaceuticals, Alexandria, Egypt) is a mixture of ambroxol (15 mg); theophylline (50 mg); and guaiphenesin (30 mg), per 5 mL syrup.Objective: To test the clinical efficacy of Farcosolvin in the treatment of AECB in a randomized, single-blinded, controlled study design.Patients and methods: One hundred patients with AECB were randomized to either Farcosolvin or guaiphenesin treatment groups
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Ambrogen-S from Sterling Lab (Medi-Genix), Ambroxol - 1-Al Ax to Alernyl-B Plus | Ambroxol is a clinically proven systemically active mucolytic agent. Use of Ambrogen-S from Sterling Lab (Medi-Genix), Pregnancy, lactation in childrens and special precautions for Ambrogen-S from Sterling Lab (Medi-Genix), prices of Ambrogen-S from Sterling Lab (Medi-Genix) . When administered orally onset of action occurs after about 30 minutes. The breakdown of acid mucopolysaccharide fibers makes the sputum thinner and less viscous and therefore more easily removed by coughing. Although sputum volume eventually decreases, its viscosity remains low for as long as treatment is maintained., drugsupdate.com - Indias leading online platform for Doctors and health care professionals. Updates on Drugs, news, journals, 1000s of videos, national and international events, product-launches and much more...Latest drugs in India, drugs, drugs update, drugs update
​Ambroxol hydrochloride can promote the exclusion of mucous secretions within the respiratory tract and reduce mucus retention, which significantly promote the expectoration. Applicable to accompanied by abnormal secretion of sputum and sputum dysfunction
Answers from trusted physicians on histiacil dextrometorfano ambroxol. First: Mucinex (guaifenesin) does not need to be taken as often as Robitussin both contain guaifinesen. If you have a cough, make sure to get a DM formulation that has a cough suppressant in it, dextromethorphan. Beware that some formulations have a decongestant, good if you have a stuffy nose, but can keep you up at night. Try to take a cough suppressant/guaifenesen to loosen secretions at night. See MD for Rx option
Ambroxol secretolytic drug molecule. Also often used in treatment of soar throat. Atoms are represented as spheres with conventional colour coding: hydrogen (white), carbon (grey), oxygen (red), nitrogen (blue), bromine (brown). - Stock Image F011/3692
All medicines may cause side effects, but many people have no, or minor, side effects.. Check with your doctor if any of these most common side effects persist or become bothersome:. Loss of appetite; nausea; sensitivity to sunlight; vomiting.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. ...
All medicines may cause side effects, but many people have no, or minor, side effects.. Check with your doctor if any of these most common side effects persist or become bothersome:. Loss of appetite; nausea; sensitivity to sunlight; vomiting.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. ...
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neo-bronchol® dissolves and loosens mucus in respiratory illnesses. It makes it easier to cough it up and clears the bronchi.
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Generics: Ambroxol, Form: SYRUP, Pack Size: 1, Brand name: COFCEL 100ML SYRUP, Manufacturer: ACEL PHARMA PVT LTD, Contains: Ambroxol 15 MG+Terbutaline 1.25 MG+Guaifenesin 50 MG+Menthol 2.5 MG, Drug ...
Specific respiratory drugs, Mucolytics, , All forms of tracheobronchitis, emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, bronchitis with bronchospasm asthma. During acute exacerbations of bronchitis it should be given with the appropriate antibiotic.
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Active ingredient: Ambroxolhydrochlorid 15 mg/5 ml Drug class: Atemwegstherapeutika Indication: Atemwegstherapeutika Originator: Mucosolvan® ► View product page. ...
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Journal of Science and Pharmacy, Jan-Mar, 2004. "Analgesic activity of stem bark of Helicteresisora Linn." "HPTLC method for determination of Carvedilol from tablet formulation" "Validated HPTLC method for estimation of Desloratadine from tablet formulation" Journal of Science and Pharmacy, Jul. - Sept. 2005 "Analgesic activity of stem bark of Kigeliapinnata Linn." Journal of Science and Pharmacy, Jan. - Mar. 2006 "CNS depressant activity of stem bark of Kigeliapinnata Linn." Indian Journal of Natural Products, 22 (2) , 2006 "Antimicrobial activity of stem bark of Helicteresisora" Indian Journal of Natural Products, 22 (3), 2006 "Antimicrobial activity of stem bark of Kigeliapinnata" Journal of Pharmacy Research, 2009, 2(8), 1311-1312. Spectrophotometric determination of Ambroxol hydrochloride from bulk and Journal of Pharmacy Research, 2009, 2 (9), 1370-1372 Quantitative determination of β - sitosterol from stem bark of Helicteresisoralinn. Asian Journal of Pharmaceutical and Clinical Research ...
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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROSCOPIC METHOD FOR ESTIMATION OF OLOPATADINE HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE IN THEIR SYNTHETIC MIXTURE ...
Ambroxol hydrochloride and glucose infusions are used in the treatment of respiratory diseases which include tracheobronchitis, emphysema and others.
Mucoslovan, also known by its generic name of ambroxol hydrochloride, can cause mild gastrointestinal problems occasionally in some people, according to Drugs.com. Known as a mucolytic agent, this...
We measured clearance of 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and
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Most Pharmacological chaperones (PCs) described until now are substrate analogues which bind to the active site of the target protein. C ons e- quently, such PCs also inhibit the target protein at higher concentrations thus rendering a narrow therapeutic window and have poor drug-like properties. Through our proprietary technology platform SEE-Tx™, we identify a new generation of non-substrate competitive pharmacological chaperones which p o- tentially offer a much broader therapeutic window. Whats more, such co m- pounds are not substrate analogues, thus presenting much better drug-like pro p- erties, particularly for indications with CNS involvement. Here we present our methodology to identify non-competitive pharmacological chaperones applied to the enzyme beta-galactosidase, whose deficiency is related with GM1 Gangliosidosis and Morquio B ...
ALVES, N. & LIBERTI, E. A. Morphoquantitative study of aging of the guinea pigs myenteric plexum collum.Rev. Chil. Anat., 20(2):125-130, 2002. SUMMARY: Applying the NADH technique in the myenteric plexus collum of young and aged guinea pigs, we have studied the morphology of ganglions and neurons, the number and arrangment of neurons and the profile area of neuronal bodies. Ganglions preferentialy elongated or without a defined morphology were observed in five collum segments (proximal, intermediate proximal, medial, intermediate distal and distal). There were no important differences in this aspect from one segment to another, whether in the same age group or between the two studied groups. It has also been observed the presence of relatively small ganglions containing a reduced number of neurons and big ganglions containing a high number of these cells. The neurons were more compacted in the ganglions of the individuals from the younger group, while the majority of ganglions from the ...
Dr. Mark Wurth is a pediatric pulmonologist at the UK Kentucky Clinic Pediatric Specialty Clinic. He is a native of Henderson, Ky. and completed his undergraduate work, a PhD and medical school at UK.. Dr. Wurths clinical interests include severe asthma and phenotype driven therapeutics for asthma management, and he is currently section head of pediatric allergy and immunology. His research interests include understanding the immune response that drives mold allergy in severe asthma and allergic bronchopulmonary mycosis. In addition to his clinical work and research, Dr. Wurth teaches first year medical students about primary immunodeficiency diseases.. ...
We appreciate the interest shown by Dr. Ginsburg in our recent conference proceedings (EHP 102, supplement 10). As stated in the preface of those proceedings, The Oxygen Radicals and Lung Injury Conference was the first of its kind dedicated to pulmonary science. Therefore, in this conference, the primary attempt was to focus on oxygen radicals and their involvement in toxic insults and the ensuin
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A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels. An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels. In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores. This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type. Calcium channel blocker Schramm M, Thomas G, Towart R, Franckowiak G (1983). "Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or ...
Sinil Pharmaceutical Co Ltd (Sinil Pharm) is a pharmaceutical company that develops and distributes new natural drugs for the treatment of degenerative arthritis and rheumatoid arthritis. The company also develops incrementally modified drugs and new biologicals to treat incurable and rare diseases. Its products include acepin, acyclovir sinil, airromin, allbupen syrup, allestop-s, alogain, ambroxol hcl sinil, amivkacon sulfate sinil 250mg, anac tab, atenolol sinil, atenon, axcef, benzacol-c, benzacol-c, betamethasone sinil, biocodyl, biomicin, bisacodyl, bonne-e-jon soft capsule, bromhexine hci sinil, bystop, and others. Sinil Pharma also provides injections and oral medications. The company conducts research and development to develop new medicines. It markets its products through its network of sales teams. Sinil Pharm is headquartered in Seoul, South Korea.. This comprehensive SWOT profile of Sinil Pharmaceutical Co Ltd provides you an in-depth strategic analysis of the companys businesses ...
2016: A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies. Hobi, N., Giolai, M., Olmeda, B., Miklavc, P., Felder, E., Walther, P., Dietl, P., Frick, M., Perez-Gil, J., Haller, T. BBA-Molecular Cell Research. http://www.ncbi.nlm.nih.gov/pubmed/27155084. 2015: Pneumocytes assemble lung surfactant as highly packed/dehydrated states with optimal surface activity. Cerrada, A., Haller, T., Cruz, A., Perez-Gil, J. Biophy. J. 109: 2295-2306. https://www.ncbi.nlm.nih.gov/pubmed/26636941. 2015: A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+-release from acidic Ca2+-stores. Fois, G., Hobi, N., Felder, E., Ziegler, A., Miklavc, P., Walther P., Rademacher P., Haller, T., Dietl. P. Cell Calcium 58: 628-637. https://www.ncbi.nlm.nih.gov/pubmed/26560688. 2014: Human Decidua-Derived Mesenchymal Stem Cells Differentiate into Functional Alveolar Type II-Like ...
GONZALES, Ralph et al. Antibiotic knowledge and self-care for acute respiratory tract infections in Mexico. Salud pública Méx [online]. 2012, vol.54, n.2, pp.152-157. ISSN 0036-3634.. OBJECTIVE: To examine knowledge of and self-treatment with antibiotics among medically-insured adults in Mexico. MATERIALS AND METHODS: We conducted a cross-sectional, interviewer-administered survey among 101 adult patients seeking care for acute respiratory tract infections in a family medicine clinic in Mexico. Knowledge scores were calculated as a composite of correct, incorrect and dont know responses. Factors associated with antibiotic knowledge and antibiotic self-treatment were explored with bivariate analyses. RESULTS: 47% of participants were taking antibiotics prior to the visit, 20% were self-treating. Antibiotic knowledge was highly variable. Many participants believed common non-antibiotic treatments for colds and coughs were antibiotics, such as ambroxol (45%), Desenfriol (45%) and paracetamol ...
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We will document the presence of underlying associated conditions such as a. Variant cystic fibrosis, b. Primary ciliary dyskinesia, c. Common variable immunodeficiency, d. Allergic bronchopulmonary mycosis, e. Autoimmune disease, Autoimmune dis ...
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Gene Information This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jul 2008]. ...
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I am also realizing why I may have been so sick. I feel like we, the doctors and I, were baffled at why I couldnt get better. I think there were some obvious issues like my immune system and body still recovering from the flu which resulted in continuous colds and illness. My body was repeatedly getting knocked down. However, I am almost positive I had an infection deep in a pocket of my lungs where mucus is completely trapped. The fevers were an obvious sign of infection, but oddly enough my mucus was thin and light in color so I never felt like I actually had a respiratory infection. I would feel better after abx (although my mucus already looked "good" so it never seemed to change much), but I would seem to fall sick again almost immediately with a cold that would result in a fever. I think I wasnt being treated long enough for how bad the hidden infection was, but since I had none of my usual obvious signs of respiratory infection we never thought to keep extending the abx. My increased ...
i was dxd in 2001, since 2005 my life became agonizing painful ms ive tried it all abc drugs,ldn, abx and a few other things. some minor improvements over the last couple years but pain is still aweful. i have ...
It seems to me that most of the people here who really believe they are getting better are taking antibiotics. Am I correct on this? Robbie, you started abx, right? I am waiting and hoping that youll soon say you ...
I found out that my (?) LLD doesnt even do parenteral abx. Since I have not been able to tolerate oral meds, yesterday he basically said good bye. His referral was....
Howard Hughes Medical Institute. Molecular Mechanisms of Membrane Penetration When Viruses Enter Cells. Recommended Readings. Empirical Articles. Abdelhakim, A. H., Salgado, E. N., Fu, X., Pasham, M., Nicastro, D., Kirchhausen, T., & Harrison, S. C. (2014). Structural correlates of rotavirus cell entry. PLoS Pathogens, 10(9), e1004355. doi:10.1371/journal.ppat.1004355. Ivanovic, T., Choi, J. L., Whelan, S. P., van Oijen, A. M., & Harrison, S. C. (2013). Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife, 2(1), e00333. doi:10.7554/eLife.00333. Schmidt, A. G., Xu, H., Khan, A. R., ODonnell, T., Khurana, S., King, L. R., … Harrison, S. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264-269. doi:10.1073/pnas.1218256109. Review Article. Harrison, S. C. (2008). Viral membrane fusion. Nature ...
Howard Hughes Medical Institute. Molecular Mechanisms of Membrane Penetration When Viruses Enter Cells. Recommended Readings. Empirical Articles. Abdelhakim, A. H., Salgado, E. N., Fu, X., Pasham, M., Nicastro, D., Kirchhausen, T., & Harrison, S. C. (2014). Structural correlates of rotavirus cell entry. PLoS Pathogens, 10(9), e1004355. doi:10.1371/journal.ppat.1004355. Ivanovic, T., Choi, J. L., Whelan, S. P., van Oijen, A. M., & Harrison, S. C. (2013). Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. eLife, 2(1), e00333. doi:10.7554/eLife.00333. Schmidt, A. G., Xu, H., Khan, A. R., ODonnell, T., Khurana, S., King, L. R., … Harrison, S. C. (2013). Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences, 110(1), 264-269. doi:10.1073/pnas.1218256109. Review Article. Harrison, S. C. (2008). Viral membrane fusion. Nature ...
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The results of this comparative study show that paraquat added in vitro inhibited lipid and protein biosynthesis by lung slices from rats and rabbits during the first 2 hours of incubation.
Hence an AB test is usually flawed. And unfortunately when people go others place to compare a product or borrow it home, we usually end up doing an AB because there is usually little time or condition for a proper ABX test, less to say use the "test of time" to be more objective hence accurate. The way I see ABX tests carried out sometimes is so bad it defeats its purpose - Listen to A, listen to B, guess. Theres like a 50% chance of getting it correct. And after you get it wrong, you shrug your shoulders. Thats it. Then you continue going on thinking that the one you like is better. Wrong. People who do that do not understand what an ABX test is, and hence full of bullshit when they say they believe in ABX testing. And worse, this boosts their ego and placebo effect, because theyd be thinking "I did an ABX test, so there must be no placebo effect." Do you know that placebo effect can also affect an ABX test also btw? Remember that hearing something different does not always mean that its ...
Folliculitis answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
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Aim of this study was to assess the effects of extrafine beclomethasone⁄formoterol treatment on lung hyperinflation and airway geometry in COPD. Data of lobar volume (%pred) and specific lobar airway volumes (siVaw) at FRC and TLC were obtained with functional imaging in 25 COPD patients (GOLD II 14, III 7, IV 4) pre- and 4h post-bronchodilator (post BD) both at baseline and after 6 months of treatment. A post BD drop was observed for both functional residual capacity (FRC) and total lung capacity (TLC) lobar volumes at baseline (FRC:-10%,p,0.01;TLC:-2%,p,0.01) and after 6 months (FRC:-12%,p,0.01;TLC:-2%,p,0.01) as index of reduced hyperinflation. siVaw did increase 4 hours after administration at both time points (+10%,p,0.01, and +8%,p,0.01). ...
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... Systematic (IUPAC) name 3-(2-methoxyphenoxy)propane-1,2-diol Identifiers CAS number 93-14-1 ATC code R05CA03 PubChem 3516 DrugBank
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After dealing with this for many, many, many years with numerous people in my family affected/treated, I no longer see things black or white. Abx definitely have worked for some people, whereas herbals have worked for others. I definitely, in our situation, do not want to pursue abx treatment at this time, but who knows what the future will bring. (Abx definitely have their time and place!) Abx has severe limitations and some pretty serious side effects, so I speak up about that. Having said that, herbals have their share of concerns to me, as well, but I am very drawn to how they help the body heal and function better (which is a limitation of abx ...
Various factors will affect the guaifenesin dosage a person should take, which this eMedTV segment lists. This article also provides detailed dosing guidelines for adults and children and offers helpful tips to ensure a safe, effective treatment process.
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Good morning everyone! Quick question. My son, who is not officially diagnosed with CF, but after speaking to the CF doctor twice, believe he at minimum has CRMS, has been sick for weeks! It started with bronchitis, he was put on abx for the bacteria found in my sons culture, finished 14 days of that. Two days later sick again, went to pediatrician who found an ear infection, after a few days on that abx (different one) he was still too sick to go to school, waking up throughout the night
I was doing pretty well on herbs since March when Levaquin gave me tendonitis and then everything I tried to take had bad side effects. I was so dizzy from the drugs I could not walk. So I started the HH capsules and increased the dose up to 16 a day. I was so mentally out of it sometimes I forgot to take it. I forgot to reorder and was out of it for 5 days during which time I took Cumanda. Anyway I dont know if it is my fault or just the BLO being so powerful, but I began to get symptoms again about 3 weeks ago. I contacted Zhang about the new HH-2 capsules and he said it might be a herx - wait and see for 1-2 weeks. I was taking ten of those a day which is the equivilent of 20 of the regular HH capsuels. It is getting worse, not better. I have headaches every night, night hot flashes, insomnia and burning in my shins - and have to get up to go to the bathroom every two hours ...
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Guaifenesin. Guaifenesin protocol is an unapproved treatment for fibromyalgia suggested in the 1990s by R. Paul St. Amand. The protocol involves three parts: titrating the guaifenesin dosage, avoiding salicylates, and following a low-carbohydrate diet if the patient is hypoglycemic. Guaifenesin has not been approved by the FDA for the treatment of fibromyalgia, and the protocol has not been shown to be effective in clinical trials. Despite the demonstrated lack of clinical efficacy, the protocol has been adopted by many due to anecdotal evidence of success.. Contents 1 Treatment details 1.1 Guaifenesin dosage 1.2 Avoiding salicylates 2 Hypothesis 3 Lack of Efficacy 4 History 5 References. Treatment details Guaifenesin dosage. The dosage is individually determined by slowly titrating the dosage up until a worsening of symptoms is noticed and there is a decrease of the lesions that can be palpated in the muscles. Patients begin with 300 mg twice a day and increase from there. The guaifenesin ...
1 Answer - Posted in: robitussin, guaifenesin - Answer: Guaifenesin aids in fertility because it improves the quality of your ...
The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.. After you begin taking theophylline and guaifenesin combination, it is very important that your doctor check your blood level of theophylline at regular intervals to find out if your dose of theophylline and guaifenesin combination needs to be changed. Do not change your dose of theophylline and guaifenesin combination unless your doctor tells you to do so.. ...
Woschnagg, C.; Rak, S.; Venge, P., 1996: Oxygen radical production by blood eosinophils is reduced during birch pollen season in allergic patients
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Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth. Dextromethorphan and guaifenesin is a combination medicine used to treat cough and...

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Find out how to take Ambroxol (drug) and its dose. Describes the best time to take the drug and precautions if any that should ... How to Take Ambroxol and Dose of Ambroxol Written & Compiled by Madhumathi Palaniappan , Medically Reviewed by The Medindia ... Ambroxol - Information. Ambroxol is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with ... Find out how to take Ambroxol (drug) and its dose. Describes the best time to take the drug and precautions if any that should ...
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Ambroxol is also anti-inflammatory, reducing redness in a sore throat. Ambroxol has recently been shown to increase activity of ... Ambroxol is often administered as an active ingredient in cough syrup. Ambroxol is indicated as "secretolytic therapy in ... Ambroxol also provides pain relief in acute sore throat. Pain in sore throat is the hallmark of acute pharyngitis. Sore throat ... Ambroxol is a potent inhibitor of the neuronal Na+ channels. This property led to the development of a lozenge containing 20 mg ...
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Ambroxol for fibromyalgia: one group pretest-posttest open-label pilot study | SpringerLinkAmbroxol for fibromyalgia: one group pretest-posttest open-label pilot study | SpringerLink

We evaluated the add-on effect of ambroxol to the treatment of fibromyalgia. We studied 25 patients with fibromyalgia. Ambroxol ... Ambroxol is a secretolytic agent used in the treatment of various airway disorders. Recently, it was discovered that this ... Chenot JF, Weber P, Friede T (2014) Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis. BMC Fam Pract 15:45. doi: ... In this pilot study, the use of ambroxol was associated to decreased fibromyalgia pain and improved fibromyalgia symptoms. The ...
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of Ambroxol Hydrochloride and Cetirizine Hydrochloride in pH 6.8 phosphate buffer. Both of these drugs obeyed Beer-Lamberts ... Ambroxol Hydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. A simple, ... Simultaneous Estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in Pharmaceutical Tablet Dosage Form by ... Hence, the proposed method can be employed for quantitative estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride ...
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Development and Validation of Stability-indicating RP-HPLC Method for The Estimation of Pseudoephedrine, Ambroxol and...Development and Validation of Stability-indicating RP-HPLC Method for The Estimation of Pseudoephedrine, Ambroxol and...

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  • De asemenea, AMBROXOL EGIS comprimate este indicat pre- si postoperator. (egis.ro)
  • Acordati atentie utilizarii AMBROXOL EGIS comprimate In cazul in care suferiti de ulcer gastroduodenal. (egis.ro)
  • Deoarece, foarte rar, au fost descrise cefalee si vertij in timpul tratamentului cu AMBROXOL EGIS comprimate, se recomanda prudenta la pacientii care conduc vehicule sau folosesc utilaje. (egis.ro)
  • Datorita continutului in lactoza al AMBROXOL EGIS comprimate pacientii cu afectiuni ereditare de intoleranta la galactoza, deficit de lactaza (Lapp), sau sindrom de malabsorbtie la glucoza-galactoza nu trebuie sa utilizeze acest medicament. (egis.ro)
  • Administrarea concomitenta de AMBROXOL EGIS comprimate si antibiotice (amoxicilina, cefuroxima, eritromicina, doxiciclina) duce la cresterea concentratiei de antibiotice la nivelul pulmonar. (egis.ro)
  • AMBROXOL EGIS comprimate nu se administreaza concomitent cu antitusive si/sau cu substante care scad secretia bronsica (de exemplu, de tip atropinic), aceste asocieri fiind nejustificate. (egis.ro)
  • Daca aveti impresia ca efectul AMBROXOL EGIS comprimate este prea puternic sau prea slab intrebati medicul dumneavoastra sau farmacistul. (egis.ro)
  • Daca ati utilizat mai mult AMBROXOL EGIS comprimate decat trebuie, anuntati imediat medicul dumneavoastra sau farmacistul. (egis.ro)
  • AMBROXOL EGIS comprimate este in general bine tolerat dar, ca toate medicamentele poate determina reactii adverse. (egis.ro)
  • Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. (wikipedia.org)
  • Compared with the former two generations of expectorant, ambroxol can provide strong dissolution of mucus. (researchmoz.us)
  • Characterized by promoting alveolar cell's intake of phosphatidylcholine and synthesis of pulmonary surfactant, reducing airway resistance, stimulating mucous gland secretion and diluting mucus so as to improve its transport and release, ambroxol is now a main species of oral expectorant in the clinic. (researchmoz.us)
  • The recently published report titled United States Ambroxol Industry 2017 Market Research Report is an in depth study providing complete analysis of the industry for the period 2017 - 2022. (mynewsdesk.com)
  • The United States Ambroxol Industry Report 2017 is an in depth study analyzing the current state of the United States Ambroxol market. (mynewsdesk.com)
  • Numan M (2017) Ambroxol hydrochloride, a chaperone therapy for Paget's disease of bone and other common autophagy-mediated aging diseases? (wikipedia.org)
  • Ambroxol is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, tracheobronchitis (respiratory tract inflammation), bronchiectasis, bronchitis with bronchospasm asthma. (medindia.net)
  • Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. (fishersci.ca)
  • Paleari D, Rossi GA, Nicolini G, Olivieri D (2011) Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood. (springer.com)
  • With the degradation of environmental pollution, the incidence of respiratory diseases is expected to keep increasing, so does the market size of ambroxol in China in the next few years. (researchmoz.us)
  • First developed and registered by German scholars in the late 1970s, ambroxol was marketed by Boehringer Ingelheim (Germany) under the trade name of Mucosolvan in Germany in 1981. (researchmoz.us)
  • In 1994, ambroxol made by Boehringer Ingelheim (Germany) entered China under the trade name of Mucosolvan, followed by Ambrohexal of HEXAL. (researchmoz.us)
  • Thus, ambroxol, an oral available drug on the market, may be a safe option for GD patients with potential disease-specific efficacy and should be expanded into a clinical trial using higher doses and placebo-controlled design. (clinicaltrials.gov)
  • The aim of this single arm, phase II study is to evaluate the efficacy and safety of adding ambroxol to patients with type 1 GD and suboptimal response to ERT. (clinicaltrials.gov)
  • It provides complete overview of United States Ambroxol market considering all the major industry trends, market dynamics and competitive scenario. (mynewsdesk.com)
  • The study on United States Ambroxol market provides analysis of China market covering the industry trends, recent developments in the market and competitive landscape. (mynewsdesk.com)
  • The linearity ranges for pseudoephedrine, ambroxol and desloratadine were 15 to 90 μg/ml, 30 to 180 μg/ml and 2.5 to 15 μg/ml, respectively with correlation coefficient 0.999. (ijpsonline.com)
  • Through years of development, ambroxol, the third generation of expectorant, has been widely applied in the clinic. (researchmoz.us)
  • Dobie, although never cured, continues taking pink pills recently and is ambroxol cheapest prices fourth in his conditions of what the diseases have done for him. (therefinedfeline.com)
  • In addition the investigators plan to open an international registry of patients with GD currently receiving ambroxol (off study). (clinicaltrials.gov)
  • HYPOTHESIS The addition of ambroxol will improve the disease related symptoms and disease impact of patients with GD with suboptimal response to ERT. (clinicaltrials.gov)
  • For this he administered deviation or endless fever about four hundred and fifty confreres not, taking an ointment of ten vicissitudes preceding his ambroxol price comparison. (therefinedfeline.com)
  • Whether a congestion generated in this best place to buy ambroxol uk has the warmth of affecting the hood in any great round i cannot presume not to determine. (therefinedfeline.com)
  • What are the storage conditions for Ambroxol? (medindia.net)