A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.
Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.
A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
An expectorant that also has some muscle relaxing action. It is used in many cough preparations.
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
The giving of drugs, chemicals, or other substances by mouth.
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Method of making images on a sensitized surface by exposure to light or other radiant energy.

Transferability of cephalothin to the alveolar cavity in thoroughbreds. (1/26)

Five Thoroughbreds were classified into 4 groups according to the administration method used for saline solution (saline), ambroxol, and cephalothin sodium (cephalothin). In group A, cephalothin was injected intravenously after oral administration of ambroxol. In group B, cephalothin was injected intravenously after oral administration of saline. Groups C and D were used as control groups. The dose of cephalothin or ambroxol was clinically administrated. Venous blood and bronchoalveolar lavage fluid (BALF) were sampled from each group. In groups A and B, cephalothin concentrations in plasma reached their maximum level 5 min after cephalothin administration and then declined over time. In plasma obtained from groups A and B, there were no significant differences in pharmacokinetic parameters (T1/2, Kel, Vd). By contrast, cephalothin concentrations in BALF reached their peak at 180 min after cephalothin administration in both groups A and B and maintained a relatively high level even after 300 min. These findings indicate that cephalothin requires a relatively long period of time to move from the blood stream to the alveolar cavity, but once transferred to the alveolar cavity, it is preserved for a long time. In groups A and B, cephalothin concentrations in BALF were approximately at the same level. However, in group A, total protein in BALF was lower at 60, 180, and 300 min than the other groups. Then, cephalothin concentration was adjusted to total protein in BALF. After adjustment to total protein in BALF, group A showed a concentration level of cephalothin approximately 1.5-fold higher than that of group B. This suggests that the transferability of cephalothin to the alveolar cavity improves as a result of the oral administration of ambroxol.  (+info)

Effect of early ambroxol treatment on lung functions in mechanically ventilated preterm newborns who subsequently developed a bronchopulmonary dysplasia (BPD). (2/26)

In a randomized trial in 102 preterm newborns with respiratory distress syndrome (RDS) it has been shown that early Ambroxol treatment (30 mg kg(-1) over the first 5 days) significantly reduces the incidence of RDS-associated complications [bronchopulmonary dysplasia (BPD), intraventricular haemorrhage, post-natal acquired pneumonia]. The aim of the present analysis was to investigate the effect of Ambroxol treatment on lung function in newborns who developed BPD. Respiratory function testing (RFT) was performed immediately after extubation and at day 28. Tidal volume (VT) and respiratory frequency (f) were measured during tidal breathing using the deadspace free flow-through technique. The lung mechanic parameter VT/maxPes was determined by measuring the maximal oesophageal pressure changes, maxPes, with a catheter tip pressure transducer. In the placebo group 36/50 infants were extubated within the first 28 days of life and 13/36 (36%) developed BPD. In the Ambroxol group 44/52 were extubated and 9/44 (20%) developed BPD. After extubation, RFT showed (i) no statistically significant difference in the ventilatory parameters of either treatment group, (ii) improved (P<0.05) lung mechanics (VT/maxPes) in Ambroxol group compared to controls (94+/-27 ml kPa(-1) vs. 8.1+/-2.6 ml kPa(-1)) and (iii) no statistically significant difference in lung function between infants with and without BPD. At day 28 we found (i) no effect of early Ambroxol treatment on lung functions, (ii) significantly (P < 0.05) higher f (58.5+/-11.7 min(-1) vs. 49.7+/-10.1 min(-1)) and significantly (P<0.01) lower V(T) (9.6+/-1.9 ml vs. 12.3+/-2.7 ml) and V(T)/maxPes (8.9+/-2.6 ml kPa(-1)] vs. 12.0+/-2.9 ml kPa(-1)) in infants with BPD compared to infants without and (iii) these differences are not influenced by early Ambroxol treatment. If the process of BPD development is induced, early Ambroxol treatment has no influence on impaired lung function at day 28.  (+info)

Effects of N-acetylcysteine and ambroxol on the production of IL-12 and IL-10 in human alveolar macrophages. (3/26)

BACKGROUND: N-acetylcysteine (NAC) and ambroxol (AMB) have recently been proposed as possible therapeutic agents in the treatment of pulmonary disorders. IL-12 plays an important role in host resistance to infection and the development of Th-1 cells. In contrast, IL-10 is involved in anti-inflammatory and immunoregulatory mechanisms. OBJECTIVE: We investigated the effects of NAC and AMB on secretions of IL-12 and IL-10 from human alveolar macrophages. METHODS: Alveolar macrophages were obtained from 7 healthy nonsmokers by bronchoalveolar lavage. The cells were first incubated with either NAC or AMB for 2 h and then cultured in lipopolysaccharide (LPS) solution for 24 h. IL-12 and IL-10 secretions were measured by ELISA. RESULT: Both NAC and AMB enhanced LPS-induced secretion of IL-12. NAC also enhanced LPS-induced IL-10 secretion, while AMB did not. The ratio IL-12/IL-10 secretion was increased by AMB, but NAC did not affect it. CONCLUSIONS: The results suggest that NAC enhances inflammatory and immune responses and prevents excessive responses reciprocally, through keeping local balance of IL-12 and IL-10 production in alveolar macrophages at inflammatory sites of bacterial pneumonia. AMB appears to strengthen inflammatory responses and cell-mediated immunity, facilitating the development of Th-1 cells, through shifting the local balance to IL-12 dominance.  (+info)

Depressant effect of ambroxol on stimulated functional responses and cell death in rat alveolar macrophages exposed to silica in vitro. (4/26)

The present study examined the effect of ambroxol on free radical production, granule enzyme release, and cell death in silica-activated rat alveolar macrophages. The action of ambroxol was assayed by measuring changes in the activities of protein kinase C (PKC) and tyrosine kinase (PTK) and in the intracellular calcium level. Ambroxol attenuated the production of superoxide, hydrogen peroxide, and nitric oxide and the release of acid phosphatase and lysozyme in macrophages activated by silica. Staurosporine, genistein, EGTA, and trifluoperazine inhibited the silica-induced free radical production and granule enzyme release. Silica induced the increase in PKC and PTK activities and the elevation of intracellular calcium level in macrophages, which was decreased by ambroxol. Silica induced a cell death and increased the caspase-3 activity in macrophages in a concentration-dependent manner. Ambroxol decreased the silica-induced cell viability loss in macrophages. The results show that ambroxol decreases the stimulated responses and cell death in rat alveolar macrophages exposed to silica, which may be accomplished by inhibition of activation processes, protein kinases, and calcium transport. The inhibitory effect of ambroxol on silica-induced cell death appears to provide the protective effect on pulmonary tissues against the toxic action of silica.  (+info)

Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. (5/26)

The protective effect of ambroxol, a mucolytic agent which has antioxidant properties and stimulates the release of pulmonary surfactant, against influenza-virus proliferation in the airway was investigated in mice. Ambroxol or the vehicle was administered intraperitoneally twice a day for 5-7 days to mice shortly after intranasal infection with a lethal dose of influenza A/Aichi/68 (H3N2) virus, and the survival rate, virus titre and levels of factors regulating virus proliferation in the airway fluid were analysed. Ambroxol significantly suppressed virus multiplication and improved the survival rate of mice. The effect of ambroxol reached a peak at 10 mg x kg(-1) x day(-1), higher doses being less effective. Ambroxol stimulated the release of suppressors of influenza-virus multiplication, such as pulmonary surfactant, mucus protease inhibitor, immunoglobulin (Ig)-A and IgG, although it stimulated the release of a trypsin-type protease that potentiates virus proliferation. In addition, ambroxol transiently suppressed release of the cytokines, tumour necrosis factor-alpha, interferon-gamma and interleukin-12, into airway fluid. Although ambroxol had several negative effects on the host defence system, overall it strikingly increased the concentrations of suppressors of influenza-virus multiplication in the airway.  (+info)

Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. (6/26)

Ambroxol has a long history for the treatment of airway diseases because of its beneficial effects on surfactant synthesis and mucus-modifying properties. Some findings, however, point to an additional effect on neuronal signal transduction: ambroxol can suppress reflexes such as the cough or the corneal reflex. The airways and the cornea are innervated by C-fibers, which express voltage-gated Na(+) channels with and without sensitivity to tetrodotoxin (TTX). In this study, we performed voltage-clamp experiments to investigate whether ambroxol affects these channel types. In rat dorsal root ganglia, TTX-resistant Na(+) currents were suppressed in a concentration-dependent manner with IC(50) values of 35.2 and 22.5 microM for tonic and phasic block, respectively. Depolarizing prepulses increased the potency of ambroxol, and steady-state inhibition curves were shifted to more negative values. The inhibition was not frequency-dependent. TTX-sensitive currents were inhibited with lower potency (approximately 50% inhibition with 100 microM). Recombinant rat brain IIA channels in Chinese hamster ovary cells were blocked with IC(50) values of 111.5 and 57.6 microM for tonic and phasic block, respectively; in contrast to TTX-resistant channels the block was frequency-dependent. Thus, ambroxol indeed blocks neuronal voltage-gated Na(+) channels, and TTX-resistant channels in sensory neurons were more sensitive than TTX-sensitive. Compared with known local anesthetics (e.g., lidocaine or benzocaine), the potency for Na(+) channel block was relatively high. A recent clinical trial has further confirmed that ambroxol relieved pain and was beneficial in patients who suffered from sore throat.  (+info)

Pulmonary alveolar proteinosis successfully treated with ambroxol. (7/26)

A 79-year-old woman was admitted to hospital due to a four-month history of a cough and dyspnea on exertion. Chest CT scans revealed ground glass opacity with thickened interlobular septa in both lungs. Bronchoalveolar lavage fluid (BALF) had milky appearance and revealed large acellular eosinophilic amorphous bodies positively stained with periodic acid-Schiff (PAS). Autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF) were present in sera and BALF from the patient. Ambroxol was started in a daily dose of 45 mg orally. Her oxygen saturation improved and abnormal shadows in CT scan disappeared 6 months after beginning the therapy.  (+info)

In vitro inhibition of human neutrophil histotoxicity by ambroxol: evidence for a multistep mechanism. (8/26)

Neutrophils are major culprits for the protease/antiprotease imbalance during various lung diseases, that is, chronic obstructive pulmonary disease, cystic fibrosis, idiopathic pulmonary fibrosis and adult respiratory distress syndrome. Thus, these cells are presently considered an ideal target for the pharmacologic control of tissue injury during these diseases. This study was planned in order to investigate if ambroxol and its precursor bromhexine are actually capable of preventing alpha-1-antitrypsin (A1AT) inactivation by stimulated neutrophils and possibly to look into the mechanisms underlying this event. Ambroxol inhibited the production of superoxide anion by activated neutrophils, whereas bromhexine had no inhibitory effect. Ambroxol decreased the production of hypochlorous acid (HOCl) from activated neutrophils with high efficiency, whereas bromhexine had a modest activity. Ambroxol and bromhexine were capable of limiting the chlorination of monochlorodimedon by HOCl, displaying the capacity of directly scavenging the oxidant. Ambroxol decreased the release of elastase and myeloperoxidase from activated neutrophils, whereas bromhexine was ineffective. Ambroxol prevented the A1AT inactivation by neutrophils, whereas bromhexine was completely ineffective. Among drugs currently available for in vivo use in humans, ambroxol is unique by virtue of its ability to prevent neutrophil-mediated A1AT inactivation via inhibition of HOCl production as well as HOCl scavenging. Also taking into account its capacity for curbing elastase release, the drug displays the potential to lessen the burden of oxidants/proteases and to increase the antiprotease shield at the site of inflammation. Thus, ambroxol appears to be a good candidate for raising attempts to develop new therapeutic histoprotective approaches to inflammatory bronchopulmonary diseases.  (+info)

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AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
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Ambroxol secretolytic drug molecule. Also often used in treatment of soar throat. Atoms are represented as spheres with conventional colour coding: hydrogen (white), carbon (grey), oxygen (red), nitrogen (blue), bromine (brown). - Stock Image F011/3692
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This dose-escalation study was investigating ambroxol [Mucosolvon; ExSAR] in patients with type I Gauchers disease. The primary endpoint was safety, as
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Syrup Erespal helps with painful cough in children, relieves spasms with laryngitis and tracheitis. The composition contains fenspirida hydrochloride, licorice root extract and auxiliary substances, as well as flavors. Allergic reactions during admission occur frequently, but rarely are serious.. Sinekod is made in the form of drops and syrup. You can take the drug from an early age, but consultation with a doctor is mandatory. The composition includes butamirate, which inhibits dry cough, affecting certain areas of the brain. Take the drug can be no more than 7 days or until the sputum is away.. Expectant syrup Gerbion has anti-inflammatory and antimicrobial properties. The preparation is made from natural raw materials: extracts of mallow and plantain. Syrup is prescribed to children from the age of two, if there is no increased sensitivity to fructose.. Lazolvan is a reliable drug that contains ambroxol. Syrup without alcohol and sugar, so allergic reactions during its use are ...
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A calcium channel opener is a type of drug which facilitates ion transmission through calcium channels. An example is Bay K8644, which is an analogue of nifedipine that specifically and directly activates L-type voltage-dependent calcium channels. In contrast to Bay K8644, which is not for clinical use, Ambroxol is a frequently used mucolytic drug that triggers lysosomal secretion by mobilizing calcium from acidic calcium stores. This effect does most likely not occur by a direct interaction between the drug and a lysosomal calcium channel, but indirectly by neutralizing the acidic pH within lysosomes. Calcium permeable ion channels in lysosomal membranes that may be activated by a luminal pH increase include two pore channels (TPCs), mucolipin TRP channels (TRPMLs) and purinergic receptors of the P2X channel type. Calcium channel blocker Schramm M, Thomas G, Towart R, Franckowiak G (1983). Activation of calcium channels by novel 1,4-dihydropyridines. A new mechanism for positive inotropics or ...
Sinil Pharmaceutical Co Ltd (Sinil Pharm) is a pharmaceutical company that develops and distributes new natural drugs for the treatment of degenerative arthritis and rheumatoid arthritis. The company also develops incrementally modified drugs and new biologicals to treat incurable and rare diseases. Its products include acepin, acyclovir sinil, airromin, allbupen syrup, allestop-s, alogain, ambroxol hcl sinil, amivkacon sulfate sinil 250mg, anac tab, atenolol sinil, atenon, axcef, benzacol-c, benzacol-c, betamethasone sinil, biocodyl, biomicin, bisacodyl, bonne-e-jon soft capsule, bromhexine hci sinil, bystop, and others. Sinil Pharma also provides injections and oral medications. The company conducts research and development to develop new medicines. It markets its products through its network of sales teams. Sinil Pharm is headquartered in Seoul, South Korea.. This comprehensive SWOT profile of Sinil Pharmaceutical Co Ltd provides you an in-depth strategic analysis of the companys businesses ...
2016: A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies. Hobi, N., Giolai, M., Olmeda, B., Miklavc, P., Felder, E., Walther, P., Dietl, P., Frick, M., Perez-Gil, J., Haller, T. BBA-Molecular Cell Research. http://www.ncbi.nlm.nih.gov/pubmed/27155084. 2015: Pneumocytes assemble lung surfactant as highly packed/dehydrated states with optimal surface activity. Cerrada, A., Haller, T., Cruz, A., Perez-Gil, J. Biophy. J. 109: 2295-2306. https://www.ncbi.nlm.nih.gov/pubmed/26636941. 2015: A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+-release from acidic Ca2+-stores. Fois, G., Hobi, N., Felder, E., Ziegler, A., Miklavc, P., Walther P., Rademacher P., Haller, T., Dietl. P. Cell Calcium 58: 628-637. https://www.ncbi.nlm.nih.gov/pubmed/26560688. 2014: Human Decidua-Derived Mesenchymal Stem Cells Differentiate into Functional Alveolar Type II-Like ...
GONZALES, Ralph et al. Antibiotic knowledge and self-care for acute respiratory tract infections in Mexico. Salud pública Méx [online]. 2012, vol.54, n.2, pp.152-157. ISSN 0036-3634.. OBJECTIVE: To examine knowledge of and self-treatment with antibiotics among medically-insured adults in Mexico. MATERIALS AND METHODS: We conducted a cross-sectional, interviewer-administered survey among 101 adult patients seeking care for acute respiratory tract infections in a family medicine clinic in Mexico. Knowledge scores were calculated as a composite of correct, incorrect and dont know responses. Factors associated with antibiotic knowledge and antibiotic self-treatment were explored with bivariate analyses. RESULTS: 47% of participants were taking antibiotics prior to the visit, 20% were self-treating. Antibiotic knowledge was highly variable. Many participants believed common non-antibiotic treatments for colds and coughs were antibiotics, such as ambroxol (45%), Desenfriol (45%) and paracetamol ...
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We will document the presence of underlying associated conditions such as a. Variant cystic fibrosis, b. Primary ciliary dyskinesia, c. Common variable immunodeficiency, d. Allergic bronchopulmonary mycosis, e. Autoimmune disease, Autoimmune dis ...
Gene Information This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq Jul 2008]. ...
Skehel, J. J., Bayley, P. M., Brown, E. B., Martin, S. R., Waterfield, M. D., White, J. M., Wilson, I. A., Wiley, D. C. Changes in the conformation of influenza-virus hemagglutinin at the ph optimum of virus-mediated membrane-fusion Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1982 79:968-972 DOI:10.1073/pnas.79.4.968 PMID:6951181 ...
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I am also realizing why I may have been so sick. I feel like we, the doctors and I, were baffled at why I couldnt get better. I think there were some obvious issues like my immune system and body still recovering from the flu which resulted in continuous colds and illness. My body was repeatedly getting knocked down. However, I am almost positive I had an infection deep in a pocket of my lungs where mucus is completely trapped. The fevers were an obvious sign of infection, but oddly enough my mucus was thin and light in color so I never felt like I actually had a respiratory infection. I would feel better after abx (although my mucus already looked good so it never seemed to change much), but I would seem to fall sick again almost immediately with a cold that would result in a fever. I think I wasnt being treated long enough for how bad the hidden infection was, but since I had none of my usual obvious signs of respiratory infection we never thought to keep extending the abx. My increased ...
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i was dxd in 2001, since 2005 my life became agonizing painful ms ive tried it all abc drugs,ldn, abx and a few other things. some minor improvements over the last couple years but pain is still aweful. i have ...
yeah, probably. I also think it wont even go through do to strict laws. Well I hope my gp is with me on that. I truly believe that an abx treatment does it. At least to a point that I ...
I found out that my (?) LLD doesnt even do parenteral abx. Since I have not been able to tolerate oral meds, yesterday he basically said good bye. His referral was....
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R05CB06 Ambroxol. R05CB07 Sobrerol. R05CB08 Domiodol. R05CB09 Letosteine. R05CB10 Combinations. R05CB11 Stepronin. R05CB13 ...
Examples are carbocisteine, ambroxol, and bromhexine. Expectorants are substances claimed to make coughing easier while ... ambroxol, and guaifenesin, sometimes with analgesics, antipyretics, anti inflammatories, and anticholinergics; and for children ...
Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V (July 2018). "Ambroxol induces autophagy and potentiates ... and ambroxol (through host directed effects in autophagy and pharmacokinetics). Rifampicin inhibits bacterial DNA-dependent RNA ...
Ambroxol is a lysosomotropic drug of clinical use to treat conditions of productive cough for its mucolytic action. Ambroxol ... Presumably for this reason, Ambroxol was also found to improve cellular function in some disease of lysosomal origin such as ... Ambroxol triggers lysosomal exocytosis via pH-dependent Ca²⁺ release from acidic Ca²⁺ stores". Cell Calcium. 58 (6): 628-37. ... "Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells". Brain. 137 (Pt 5): ...
Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase, so it may be a useful ... Ambroxol triggers the secretion of lysosomes from cells by inducing a pH-dependent calcium release from acidic calcium stores. ... Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell Calcium. 58 (6): 628-637. ... "Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells". Brain. 137 (5): 1481- ...
LCT has supported trials in ambroxol, exenatide, simvastatin, liraglutide and others. A month later, in October, the Institute ...
Ambroxol is another drug that has beneficial effects in Vero E6 cells. The functional roles of galectins in cellular response ... Timmins, Graham S; Bradfute, Steven B; Deretic, Vojo; Kumar, Suresh; Clarke, Elizabeth C; Ye, Chunyan (2020-08-11). "Ambroxol ...
Mucolytic drugs available include acetylcysteine, ambroxol, bromhexine, carbocisteine, erdosteine, mecysteine, and dornase alfa ...
2008). "Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells". Respiratory Physiology & ...
R05CB06 Ambroxol. R05CB07 Sobrerol. R05CB08 Domiodol. R05CB09 Letosteine. R05CB10 Combinations. R05CB11 Stepronin. R05CB12 ...
Cefuroxime and ambroxol". Arzneimittel-Forschung. 50 (8): 700-11. doi:10.1055/s-0031-1300276. PMID 10994153.. ...
Acebrophylline, an airway mucoregulator and anti-inflammatory agent is a combination product of ambroxol and theophylline 7 ...
In contrast to Bay K8644, which is not for clinical use, ambroxol is a frequently used mucolytic drug that triggers lysosomal ... Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores". Cell Calcium. 58 (6): 628-637. ...
... sobrerol and ambroxol). Chronic Obstructive Pulmonary Disease Evidence obtained in patients with stable chronic bronchitis/COPD ...
Ambroxol is a lysosomotropic drug of clinical use to treat conditions of productive cough for its mucolytic action. Ambroxol ... Ambroxol was also found to improve cellular function in some disease of lysosomal origin such as Parkinson's or lysosomal ... "Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells". Brain. 137 (5): 1481- ... "A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores" ...
... ambroxol, salbutamol, phenylephrine, and dexamethasone. The marketing of the Claritin brand is important in the history of ...
Therapies under study as of 2019 aim to reduce brain levels of alpha-synuclein (with the pharmaceuticals ambroxol, NPT200-11, ...
... ambroxol) Pharmaton (standardized ginseng extract, vitamins, minerals, trace elements) Silomat / Bisoltussin / Bisolvon ...
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... combinations R03CC63 Clenbuterol and ambroxol QR03CC90 Clenbuterol, combinations R03DA01 Diprophylline R03DA02 Choline ...
As of 2017, in a combination drug with ambroxol, it was available as Aliviatos, Ambroclar, Antitusivo L Labsa, Bronar, ... and in a combination drug with ambroxol and salbutamol as Sibilex.[25] ...
Both ambroxol and its parent drug bromhexine have been shown to induce autophagy in several cell types, and ambroxol was shown ... Ambroxol also enhances lung levels of a wide range of antibiotics. Ambroxol also had activity against SARS CoV2 in Vero E6 ... Ambroxol is also anti-inflammatory, reducing redness in a sore throat. Ambroxol has recently been shown to increase activity of ... Ambroxol is often administered as an active ingredient in cough syrup. It was patented in 1966 and came into medical use in ...
Ipecac was used in cough mixtures as an expectorant or an emetic from the 18th until the early 20th century.[citation needed] For instance, Ipecac and opium were used to produce Dover's powder, which was used in syrup form.[citation needed] In 1965, the FDA approved the sale of up to one ounce of syrup of ipecac without a prescription. At the time it was approved, its use was recommended by the AAP, AAPCC, AMA, and the FDA's medical advisory board as a method to induce vomiting "for quick first-aid use in the home, under medical supervision", for use in cases of accidental poisoning.[2][3] Current guidelines from the American Academy of Pediatrics, however, strongly advise against this and in fact recommend the disposal of any syrup of ipecac present in the home.[4] Many toxicological associations have also issued position papers recommending against its use as a first-line treatment for most ingested poisons,[5] because of a lack of evidence that syrup of ipecac actually helps improve the ...
In the translation of messenger RNA molecules to produce polypeptides, cysteine is coded for by the UGU and UGC codons. Cysteine has traditionally been considered to be a hydrophilic amino acid, based largely on the chemical parallel between its sulfhydryl group and the hydroxyl groups in the side chains of other polar amino acids. However, the cysteine side chain has been shown to stabilize hydrophobic interactions in micelles to a greater degree than the side chain in the nonpolar amino acid glycine and the polar amino acid serine.[19] In a statistical analysis of the frequency with which amino acids appear in different chemical environments in the structures of proteins, free cysteine residues were found to associate with hydrophobic regions of proteins. Their hydrophobic tendency was equivalent to that of known nonpolar amino acids such as methionine and tyrosine (tyrosine is polar aromatic but also hydrophobic[20]), those of which were much greater than that of known polar amino acids such ...
Intravenous and oral formulations of acetylcysteine are available for the treatment of paracetamol (acetaminophen) overdose.[13] When paracetamol is taken in large quantities, a minor metabolite called N-acetyl-p-benzoquinone imine (NAPQI) accumulates within the body. It is normally conjugated by glutathione, but when taken in excess, the body's glutathione reserves are not sufficient to deactivate the toxic NAPQI. This metabolite is then free to react with key hepatic enzymes, thereby damaging liver cells. This may lead to severe liver damage and even death by acute liver failure. In the treatment of acetaminophen overdose, acetylcysteine acts to maintain or replenish depleted glutathione reserves in the liver and enhance non-toxic metabolism of acetaminophen.[14] These actions serve to protect liver cells from NAPQI toxicity. It is most effective in preventing or lessening hepatic injury when administered within 8-10 hours after overdose.[14] Research suggests that the rate of liver toxicity ...
Since mannitol is found in a wide variety of natural products, including almost all plants, it can be directly extracted from natural products, rather than chemical or biological syntheses. In fact, in China, isolation from seaweed is the most common form of mannitol production.[18] Mannitol concentrations of plant exudates can range from 20% in seaweeds to 90% in the plane tree. It is a constituent of saw palmetto (Serenoa).[25] Traditionally, mannitol is extracted by the Soxhlet extraction, using ethanol, water, and methanol to steam and then hydrolysis of the crude material. The mannitol is then recrystallized from the extract, generally resulting in yields of about 18% of the original natural product. Another method of extraction is using supercritical and subcritical fluids. These fluids are at such a stage that no difference exists between the liquid and gas stages, so are more diffusive than normal fluids. This is considered to make them much more effective mass transfer agents than ...
Reports of recreational use of glaucine have recently been published, and effects include dissociative-type symptoms; feeling detached and 'in another world', as well as nausea, vomiting and dilated pupils. These reports mirror those about the effects of clinical use, which state dissociative-type symptoms as well as lethargy, fatigue, hallucinations.[8][9] Investigation of side effects in a clinical setting also reports that the hallucinatory effects manifest as bright and colorful visualizations. They also report that patients perceive their environments clearly yet feel detached from it; "the patient sees and understands everything and is oriented well enough, but cannot take a clear and adequate action".[8]. One particular report of recreational use gone awry described the form of distribution as tablets being marketed as a 1-benzylpiperazine (BZP)-free "herbal high" which the patient referred to as "head candy".[9]. ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
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Both ambroxol and its parent drug bromhexine have been shown to induce autophagy in several cell types, and ambroxol was shown ... Ambroxol also enhances lung levels of a wide range of antibiotics. Ambroxol also had activity against SARS CoV2 in Vero E6 ... Ambroxol is also anti-inflammatory, reducing redness in a sore throat. Ambroxol has recently been shown to increase activity of ... Ambroxol is often administered as an active ingredient in cough syrup. It was patented in 1966 and came into medical use in ...
A list of US medications equivalent to Ambroxol Teva is available on the Drugs.com website. ... Ambroxol Teva is a medicine available in a number of countries worldwide. ... Ambroxol Teva may be available in the countries listed below.. Ingredient matches for Ambroxol Teva. Ambroxol. Ambroxol ...
A list of US medications equivalent to Ambroxol RUP Borisov is available on the Drugs.com website. ... Ambroxol RUP Borisov is a medicine available in a number of countries worldwide. ... Ingredient matches for Ambroxol RUP Borisov. Ambroxol. Ambroxol is reported as an ingredient of Ambroxol RUP Borisov in the ... Ambroxol RUP Borisov. Ambroxol RUP Borisov may be available in the countries listed below. ...
Find treatment reviews for ambroxol-amoxicillin from other patients. Learn from their experiences about effectiveness, side ...
Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include ... Ambroxol hydrochloride is not currently marketed in the United States but is used in other parts of the world. Patients should ... Treatment with ambroxol hydrochloride can lead to bowel movement changes in patients. This side effect can cause certain ... Rarely, patients taking ambroxol hydrochloride can experience an allergic reaction to this medication upon initial use. ...
Find the most comprehensive real-world treatment information on Ambroxol at PatientsLikeMe. 2 patients with fibromyalgia, ... bipolar I disorder or psoriasis currently take Ambroxol. ... Stopped taking Ambroxol Duration. Patients. This item is ... Why patients stopped taking Ambroxol. Multiple reasons could be selected. Reason. Patients. This item is relevant to you: ... What is Ambroxol?. Category: Prescription Drugs Most popular types: Frubizin Akut Mucoangin Mucopect Mucosal Mucosolvan Retard ...
The recently published report titled United States Ambroxol Industry 2017 Market Research Report is an in depth study providing ... United States Ambroxol Market 2018 1 Ambroxol Overview. 1.1 Product Overview and Scope of Ambroxol. 1.2 Classification of ... 4.2 United States Ambroxol Revenue and Market Share by Type (2012-2017). 4.3 United States Ambroxol Price by Type (2012-2017). ... 6.1.2 Ambroxol Product Category, Application and Specification. 6.1.2.1 Product A. 6.1.2.2 Product B. 6.1.3 Teva Ambroxol Sales ...
Find out how to take Ambroxol (drug) and its dose. Describes the best time to take the drug and precautions if any that should ... How to Take Ambroxol and Dose of Ambroxol Written & Compiled by Madhumathi Palaniappan , Medically Reviewed by The Medindia ... Ambroxol - Information. Ambroxol is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with ... Find out how to take Ambroxol (drug) and its dose. Describes the best time to take the drug and precautions if any that should ...
... ambroxol hydrochloride manufacturers, ambroxol hydrochloride suppliers, ambroxol hcl exporters and manufacturing companies from ... Here you will find listings of ambroxol hcl, ... Ambroxol is a mucolytic agent which reduces the thickness of ... Ambroxol Hydrochloride Syrup Erlotinib Hydrochloride Thiamine Hydrochloride Glucosamine Hydrochloride L Cysteine Hydrochloride ... Ambroxol Hydrochloride is a clinically proven systemically active mucolytic agent. When administered orally onset of action ...
Effect of ambroxol on blood and CSF biomarkers [ Time Frame: Day 1-186 ]. Quantify the effects of ambroxol on biomarkers of ... Glucocerebrosidase and ambroxol levels in blood and cerebrospinal fluid [ Time Frame: Day 1-186 ]. Assess ambroxols central ... Ambroxol in Disease Modification in Parkinson Disease (AiM-PD). The safety and scientific validity of this study is the ... Tolerability and Pharmacodynamic Effects of Ambroxol in Patients With Parkinson Disease: Ambroxol in Disease Modification in ...
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Ambroxol(Aeroflux) generic is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with bronchitis ... Ambroxol +Pharma, Ambroxol Abz, Ambroxol Acis, Ambroxol Al Comp, Ambroxol Al, Ambroxol Aphar, Ambroxol Aristo, Ambroxol Arrow, ... Ambroxol Cinfa, Ambroxol Domesco, Ambroxol Genfar, Ambroxol Germed, Ambroxol Jaba, Ambroxol Jarabe, Ambroxol LCh, Ambroxol La ... Ambroxol Stada, Ambroxol Temmler, Ambroxol Teva Conseil, Ambroxol Vramed, Ambroxol, Ambroxol-1a Pharma, Ambroxol-Ct, Ambroxol- ...
Ambroxol. Drug Summary. 2015 Full text (in our servers) *DGF. Dirección General de Farmacia. Servicio Canario de la Salud. ... Ambroxol. Ficha técnica. 2016 Full text (in our servers) *MRI-CTS. ... Celltius™. Contains other elements than Ambroxol in its composition *Coricidin Expec (Mexico)™. Contains other elements than ... The pharmacokinetics and bioequivalence of various dosage forms of ambroxol]. Arzneimittelforschung. 1985;35(10):1591-5. German ...
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We evaluated the add-on effect of ambroxol to the treatment of fibromyalgia. We studied 25 patients with fibromyalgia. Ambroxol ... Ambroxol is a secretolytic agent used in the treatment of various airway disorders. Recently, it was discovered that this ... Chenot JF, Weber P, Friede T (2014) Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis. BMC Fam Pract 15:45. doi: ... In this pilot study, the use of ambroxol was associated to decreased fibromyalgia pain and improved fibromyalgia symptoms. The ...
Ambroxol is sold over the counter in much of the world as an expectorant at doses of 75-120 mg/day. Furthermore, Ambroxol is ... The best response was in the lightest patient (who received 3 mg/kg/day), suggesting that Ambroxol was under dosed. Ambroxol ... Patients will be randomized to receive placebo or Ambroxol (1050mg). Participants randomized to Ambroxol group will begin with ... Ambroxol as a Treatment for Parkinsons Disease Dementia. The safety and scientific validity of this study is the ...
Ambroxol secretolytic drug molecule. Also often used in treatment of soar throat. Atoms are represented as spheres with ... Caption: Ambroxol secretolytic drug molecule. Also often used in treatment of soar throat. Atoms are represented as spheres ... Keywords: 3 dimensional, 3d, ambroxol, ambroxole, anaesthetic, antitussive, artwork, atomic structure, atoms, biological, ...
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The Investigation Report on Chinas Ambroxol Market, 2018-2022 report has been added to ResearchAndMarkets.coms offering. ... The chemical constituent of Ambroxol is ambroxol hydrochloride, an active metabolite of Bromhexine. In 1981, Ambroxol (trade ... Ambroxol is sold in China in the dosage forms of injections, solutions, syrups, granules, tablets and capsules. Injections ... After years of development, third-generation expectorant Ambroxol has become the most common drug in the clinical treatment of ...
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Generic Ambroxol tablets are mucolytic agents used for treating asthma. It costs $0.40 per tablet. Order more than a months ... How will Ambroxol work in my body?. How should Ambroxol be taken?. How to reduce the risk of Ambroxol drug interactions and ... What are the questions to ask your doctor before taking Ambroxol? Is it possible for me to take Ambroxol with other drugs?. ... Ambroxol should be taken with food. What if you miss a dose of Ambroxol?. If your physician has instructed or directed you to ...
Experimental: Ambroxol Ambroxol therapy will be dosed up to 600 mg/day divided to twice a day starting 150 mg for the first ... Drug: Ambroxol Ambroxol Hydrochloride therapy will be dosed up to 600 mg/day divided to twice a day starting 150 mg for the ... In addition to a mucolytic action, ambroxol has antioxidant and anti-inflammatory properties. Importantly, ambroxol therapy was ... Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy. The safety and ...
of Ambroxol Hydrochloride and Cetirizine Hydrochloride in pH 6.8 phosphate buffer. Both of these drugs obeyed Beer-Lamberts ... Ambroxol Hydrochloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. A simple, ... Simultaneous Estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in Pharmaceutical Tablet Dosage Form by ... Hence, the proposed method can be employed for quantitative estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride ...
Exporters of Ambroxol cough syrup in Hyderabad India. Shrion Pharmaceuticals offering fine quality Ambroxol cough syrup at ... Ambroxol guaiphenesin terbutaline syrup. Ambroxol: ambroxol is used to treat certain diseases of the respiratory tract and to ...
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Global Ambroxol Hydrochloride Market Research Report 2016 is a market research report available at US $2900 for a Single User ... 1 Ambroxol Hydrochloride Market Overview. 1.1 Product Overview and Scope of Ambroxol Hydrochloride. 1.2 Ambroxol Hydrochloride ... 5.2 Global Ambroxol Hydrochloride Revenue and Market Share by Type (2011-2016). 5.3 Global Ambroxol Hydrochloride Price by Type ... 2.5.1 Ambroxol Hydrochloride Market Concentration Rate. 2.5.2 Ambroxol Hydrochloride Market Share of Top 3 and Top 5 ...
  • Ambroxol is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. (wikipedia.org)
  • Ambroxol is an expectorant that has been available over the counter in more than 50 countries for over 30 years. (clinicaltrials.gov)
  • Ambroxol is sold over the counter in much of the world as an expectorant at doses of 75-120 mg/day. (clinicaltrials.gov)
  • After years of development, third-generation expectorant Ambroxol has become the most common drug in the clinical treatment of respiratory diseases. (pharmiweb.com)
  • Through years of development, ambroxol, the third generation of expectorant, has been widely applied in the clinic. (researchmoz.us)
  • Compared with the former two generations of expectorant, ambroxol can provide strong dissolution of mucus. (researchmoz.us)
  • Characterized by promoting alveolar cell's intake of phosphatidylcholine and synthesis of pulmonary surfactant, reducing airway resistance, stimulating mucous gland secretion and diluting mucus so as to improve its transport and release, ambroxol is now a main species of oral expectorant in the clinic. (researchmoz.us)
  • Ambroxol (NA-872), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. (medchemexpress.com)
  • Ambroxol Hydrochloride is an effective expectorant administered for various respiratory problems. (knoji.com)
  • Ambroxol is not an expectorant. (knoji.com)
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  • Ambroxol stimulates the synthesis and release of surfactant in the respiratory tract and acts as a mucoactive/expectorant drug. (guidetopharmacology.org)
  • Earlier research had indicated that the expectorant ambroxol is beneficial for Gaucher disease patients , as it acts to boost the activity of the faulty glucocerebrosidase enzyme. (gaucherdiseasenews.com)
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  • Both ambroxol and its parent drug bromhexine have been shown to induce autophagy in several cell types, and ambroxol was shown to potentiate rifampicin therapy in a model of tuberculosis through host directed effects. (wikipedia.org)
  • The chemical constituent of Ambroxol is ambroxol hydrochloride, an active metabolite of Bromhexine. (pharmiweb.com)
  • There is concern over the number of allergic reactions, including anaphylaxis, with the use of ambroxol (to which bromhexine is metabolised). (thewavebroadbeach.com)
  • Ambroxol- and bromhexine-containing medicines are marketed as single products or as fixed combination products bromuexina various other active ingredients. (thewavebroadbeach.com)
  • Ambroxol and bromhexine are mainly used by mouth as expectorants to help make the mucus thinner and therefore easier to be cleared away in patients with short- or long-term diseases of the lungs or airways. (thewavebroadbeach.com)
  • Information to patients There is a small risk of allergy and skin reactions with ambroxol and bromhexine used as expectorants to clear mucus in the airways. (thewavebroadbeach.com)
  • The risk of anaphylactic reactions and SCARs with ambroxol or bromhexine is low. (thewavebroadbeach.com)
  • The chemical composition of ambroxol is ambroxol hydrochloride which is the active metabolite of bromhexine. (researchmoz.us)
  • Enhancement of lung levels of antibiotics by ambroxol and bromhexine. (medchemexpress.com)
  • Ambroxol is an active N-desmethyl metabolite of the mucolytic, bromhexine. (pharmabizconnect.com)
  • Examples are carbocisteine, ambroxol, and bromhexine. (wikipedia.org)
  • AdvaCare Ambroxol Hydrochloride + Glucose Infusions are manufactured in our facilities located in China, India and USA. (advacarepharma.com)
  • Trumac Healthcare is one of the leading Dextromethorphan Cetirizine Phenylephrine Ambroxol Tablets Manufacturers Suppliers all over India. (trumachealthcare.net)
  • Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion. (fishersci.ca)
  • In 1981, Ambroxol (trade name: Mucosolvan) developed by German company Boehringer Ingelheim was launched. (pharmiweb.com)
  • Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin. (thewavebroadbeach.com)
  • First developed and registered by German scholars in the late 1970s, ambroxol was marketed by Boehringer Ingelheim (Germany) under the trade name of Mucosolvan in Germany in 1981. (researchmoz.us)
  • In 1994, ambroxol made by Boehringer Ingelheim (Germany) entered China under the trade name of Mucosolvan, followed by Ambrohexal of HEXAL. (researchmoz.us)
  • Ambroxol is reported as an ingredient of Mucosolvan Pediatrico in the. (thedojo.mobi)
  • Ingredient matches for Mucosolvan Pediatrico Ambroxol Ambroxol is reported as an ingredient of Mucosolvan Pediatrico in the following countries: It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. (thedojo.mobi)
  • In case of pregnancy or breast-feeding consult with your doctor before using Ambroxol (mucosolvan) syrup. (knoji.com)
  • Ambroxol is the active agent in Mucosolvan. (decadurabolinsteroids.com)
  • 4. As the active ingredient in Mucosolvan, Ambroxol has offered proven safety and effectiveness for many years. (decadurabolinsteroids.com)
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  • Krontec Healthcare offers Kronof-L which contains Ambroxol HCL 15mg + Levocetirizine HCL 2.5mg. (pharmabizconnect.com)
  • Following oral administration of ambroxol hydrochloride tablets or syrup, certain patients can develop stomach upset side effects. (livestrong.com)
  • Wholesaler of a wide range of products which include mucolite ambroxol hydrochloride tablets, deriphyllin od tablets, pirfenex 400 mg tablets pirfenidone (400mg), pirfenex tablet, pirfeheal 200mg tablet and pirfenex pirfenidone tablets. (vishakhaimpex.in)
  • Apart from Dextromethorphan Cetirizine Phenylephrine Ambroxol Tablets Manufacturers Suppliers, we at Trumac Healthcare provide range of other products across several divisions. (trumachealthcare.net)
  • However, with therapeutic effect of a composition containing Ambroxol or its salt as the act is its substance and intended for local use by direct application to the skin, accordingly, the mucous membrane and to treat them in the level technique is not described. (russianpatents.com)
  • Detailed information related to Ambroxol Levosalbutamol & Guaiphenesin Syrups uses, composition, dosage, side effects and reviews is listed below. (medzeellifescience.com)
  • 100ml Terbutaline Sulphate Ambroxol Hydrochloride Guaiphenesin And Menthol Syrup offered by us has accurate chemical composition and assures long term effects. (kolazpcdpharma.com)
  • 100ml Terbutaline Sulphate Ambroxol Hydrochloride Guaiphenesin And Menthol Syrup is indicated to be used for providing relief from cough associated with various conditions including bronchitis, bronchopulmonary disorders, and bronchial asthma. (kolazpcdpharma.com)
  • Ambroxol is a mucolytic agent, prescribed for various respiratory diseases such as emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, tracheobronchitis (respiratory tract inflammation), bronchiectasis, bronchitis with bronchospasm asthma. (medindia.net)
  • In addition to a mucolytic action, ambroxol has antioxidant and anti-inflammatory properties. (clinicaltrials.gov)
  • Ambroxol is a clinically proven systemically active mucolytic agent. (drugsupdate.com)
  • Ambroxol hydrochloride acts as an expectoration improver and mucolytic agent. (soinsvie.in)
  • Ambroxol is a mucolytic agent. (drugbank.com)
  • Inhalex 15 mg Respules (Ambroxol) belongs to a class of drugs called expectorants (aid expulsion of mucus as cough) or mucolytic (liquefy and loosen mucus). (alldaygeneric.com)
  • Like other medicines, Ambroxol can cause some side effects. (internationaldrugmart.com)
  • This is a combination of four medicines: Ambroxol, cetirizine, dextromethorphan and phenylephrine which relieve dry cough. (trumachealthcare.net)
  • Ambroxol is a secretolytic agent used in the treatment of various airway disorders. (springer.com)
  • Ambroxol is indicated for secretolytic therapy in bronchoplmonary disease with abnormal mucus secretion and transport. (drugbank.com)
  • Ambroxol is often administered as an active ingredient in cough syrup. (wikipedia.org)
  • Offering you a complete choice of products which include ambroxol cough syrup, dextromethrophan phenylpherin cpm cough syrup, levosalbutamol ambroxol cough syrup, terbuxol a syrup, ambroxol guaiphenesin & terbutaline cough syrup and cefpodoxime 100mg dry syrup. (vibdrugsbiosciences.com)
  • We are one of the most acclaimed suppliers and trader of Ambroxol Guaiphenesin & Terbutaline Cough Syrup . (vibdrugsbiosciences.com)
  • Wholesale Trader of a wide range of products which include ambroxol hydrochloride syrup, lycopene multivitamin syrup and dextromethorphan cough syrup. (ssnutracare.in)
  • Surfactant acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.Ambroxol is often administered as an active ingredient in cough syrup. (decadurabolinsteroids.com)
  • Rarely, patients taking ambroxol hydrochloride can experience an allergic reaction to this medication upon initial use. (livestrong.com)
  • Always consult your doctor or pharmacist before taking ambroxol hydrochloride and glucose infusions. (advacarepharma.com)
  • Ambroxol is also anti-inflammatory, reducing redness in a sore throat. (wikipedia.org)
  • Retrieved from " https: Ambroxol is also anti-inflammatoryreducing redness in a sore throat. (thewavebroadbeach.com)
  • Assess ambroxol's central nervous system and cerebrospinal fluid penetration, and its binding to GCase by examining GCase activity & ambroxol levels at 5 intra-participant dose escalations from day 1 to day 186. (clinicaltrials.gov)
  • Recently, the Mahuran Lab identified Ambroxol by screening a library of compounds as an agent that stabilizes wild-type (normal) GCase. (clinicaltrials.gov)
  • By stabilizing GCase, Ambroxol is able to markedly increase GCase protein and activity in normal and Gaucher disease fibroblasts at doses of 10 micromolar. (clinicaltrials.gov)
  • Ambroxol can also increase GCase in normal mouse neuronal cultures to more than 150% of normal at a dose of 30 micromolar. (clinicaltrials.gov)
  • Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. (medchemexpress.com)
  • Malerba M, Ragnoli B (August 2008), "Ambroxol in the 21st century: pharmacological and clinical update", Expert Opin Drug Metab Toxicol, 4 (8): 1119-29, doi:10.1517/17425255.4.8.1119, PMID 18680446, S2CID 72361856 de Mey C, et al. (wikipedia.org)
  • 2008), "Efficacy and safety of ambroxol lozenges in the treatment of acute uncomplicated sore throat", Arzneimittelforschung, 58 (11): 557-68, doi:10.1055/s-0031-1296557, PMID 19137906 Püschmann S, Engelhorn R (1978). (wikipedia.org)
  • It was also recently shown that ambroxol triggers exocytosis of lysosomes by releasing calcium from acidic cellular calcium stores. (wikipedia.org)
  • Previous studies have shown that ambroxol can penetrate the brain in rodent and non-human primate models, and may have an effect in slowing PD. (clinicaltrials.gov)
  • It was recently shown that Ambroxol triggers exocytosis of lysosomes ( Source ). (scienceofparkinsons.com)
  • Compared with the first and second generations of expectorants, Ambroxol excels in dissolving mucus. (pharmiweb.com)
  • SUBSTANCE: present invention refers to application of antiinflammatory and local anaesthetic pharmaceutical compositions containing ambroxol or one of its pharmacologically acceptable salts for local application for skin diseases chosen from the group including anaesthesia, burning, itching, inflammation, mosquito stings and skin redness of allergic, immunologic or idiopathic origin, applied directly on the skin. (russianpatents.com)
  • The present invention relates to possess anti-inflammatory and mestnoanesteziruushim properties, pharmaceutical compositions containing Ambroxol or one of its pharmacologically acceptable salts, preferably Ambroxol in the form of its hydrochloride, and intended for local use by direct application or applying to the skin and/or mucous membrane. (russianpatents.com)
  • With the invention it has been unexpectedly found that pharmaceutical compositions for topical application containing Ambroxol or one of its pharmacologically acceptable salts and intended for direct application or applying to the skin and/or mucous membranes, anti-inflammatory and mestnoanesteziruushim properties. (russianpatents.com)
  • Preferred pharmaceutical compositions for topical application containing Ambroxol in the form of its hydrochloride. (russianpatents.com)
  • Especially preferred pharmaceutical compositions for topical application in the form of a dosage form selected from the group including gels, hydrophilic paste, mash and solutions containing Ambroxol from 0.1 to 20 wt. (russianpatents.com)
  • In another preferred embodiment, the invention provides pharmaceutical compositions for topical application in the form mucoadhesive patches containing Ambroxol from 1 to 50 wt. (russianpatents.com)
  • De asemenea, AMBROXOL EGIS comprimate este indicat pre- si postoperator. (egis.ro)
  • Acordati atentie utilizarii AMBROXOL EGIS comprimate In cazul in care suferiti de ulcer gastroduodenal. (egis.ro)
  • Deoarece, foarte rar, au fost descrise cefalee si vertij in timpul tratamentului cu AMBROXOL EGIS comprimate, se recomanda prudenta la pacientii care conduc vehicule sau folosesc utilaje. (egis.ro)
  • Datorita continutului in lactoza al AMBROXOL EGIS comprimate pacientii cu afectiuni ereditare de intoleranta la galactoza, deficit de lactaza (Lapp), sau sindrom de malabsorbtie la glucoza-galactoza nu trebuie sa utilizeze acest medicament. (egis.ro)
  • Administrarea concomitenta de AMBROXOL EGIS comprimate si antibiotice (amoxicilina, cefuroxima, eritromicina, doxiciclina) duce la cresterea concentratiei de antibiotice la nivelul pulmonar. (egis.ro)
  • AMBROXOL EGIS comprimate nu se administreaza concomitent cu antitusive si/sau cu substante care scad secretia bronsica (de exemplu, de tip atropinic), aceste asocieri fiind nejustificate. (egis.ro)
  • Daca aveti impresia ca efectul AMBROXOL EGIS comprimate este prea puternic sau prea slab intrebati medicul dumneavoastra sau farmacistul. (egis.ro)
  • Daca ati utilizat mai mult AMBROXOL EGIS comprimate decat trebuie, anuntati imediat medicul dumneavoastra sau farmacistul. (egis.ro)
  • AMBROXOL EGIS comprimate este in general bine tolerat dar, ca toate medicamentele poate determina reactii adverse. (egis.ro)
  • AMBROXOL EGIS comprimate este indicat in afectiuni bronhopulmonare cronice, in afectiuni bronsice acute si episoade acute ale bronhopneumopatiei cronice. (eprospect.ro)
  • 1. Ce este AMBROXOL EGIS comprimate si pentru ce este utilizat? (eprospect.ro)
  • 3. Cum se utilizeaza AMBROXOL EGIS comprimate? (eprospect.ro)
  • 5. Cum se pastreaza AMBROXOL EGIS comprimate? (eprospect.ro)
  • Ambroxol Levosalbutamol & Guaiphenesin Syrup is a medicine that is used for the treatment of Bronchitis, Back Pain, Cough, Congestion, Common Cold, Breathing Illnesses and other conditions. (medzeellifescience.com)
  • The following is a list of possible side-effects that may occur from all constituting ingredients of Ambroxol Levosalbutamol & Guaiphenesin Syrup. (medzeellifescience.com)
  • The present study will test the hypothesis that the medication Ambroxol is safe and well tolerated and will improve cognitive and motor symptoms of Parkinson's Disease Dementia (PDD). (clinicaltrials.gov)
  • Importantly, this new data provides further justification for the ongoing Ambroxol clinical trial programme which Cure Parkinson's, Van Andel Institute and John Black Charitable Foundation are supporting. (cureparkinsons.org.uk)
  • This is important data given that there is currently a clinical trial being conducted for Ambroxol in Parkinson's disease. (scienceofparkinsons.com)
  • We have previously discussed the potential use of Ambroxol in the treatment of Parkinson's disease ( Click here to read that post). (scienceofparkinsons.com)
  • What is the connection between Ambroxol and Parkinson's disease? (scienceofparkinsons.com)
  • Ambroxol has recently been shown to increase activity of the lysosomal enzyme glucocerebrosidase. (wikipedia.org)
  • In these samples the Investigators will measure ambroxol drug levels, assess whether the glucocerebrosidase enzyme has been stimulated and the levels of other substances thought to be associated with the development of PD and confirm whether the study drug has penetrated the cerebrospinal fluid and CNS. (clinicaltrials.gov)
  • Ambroxol has been shown to raise the levels of the enzyme beta-glucocerebrosidase resulting in lower the levels of the protein alpha-synuclein, both of which have been shown to improve cognition in mouse models. (clinicaltrials.gov)
  • Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. (medchemexpress.com)
  • In this study, the researchers treated mice with Ambroxol for 12 days and then measured the level of glucocerebrosidase activity in the brain. (scienceofparkinsons.com)
  • When they looked at the level of glucocerebrosidase enzyme activity in normal mice, they found an increase of approximately 20% (in mice treated with 4mM Ambroxol). (scienceofparkinsons.com)
  • One curious finding was that this dose was the only dose that increase glucocerebrosidase activity (1, 3, and 5mM of Ambroxol had no effect). (scienceofparkinsons.com)
  • Ambroxol was prescribed at the usual clinical dose of 30 mg PO 3 times a day × 1 month. (springer.com)
  • It should already be mentioned that, towards the occurrence of his observation in marseilles, he got roseola, which not disappeared back not, leaving behind a where to buy generic ambroxol online to frequent cells. (therefinedfeline.com)
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  • It captures ambroxol hydrochloride market trends, pays close attention to ambroxol hydrochloride manufacturers and names suppliers. (marketpublishers.com)
  • Many state-of-the-art clinical studies have demonstrated the efficacy of ambroxol in relieving pain in acute sore throat, with a rapid onset of action, with its effect lasting at least three hours. (wikipedia.org)
  • Participants will administer ambroxol at five dose levels and will undergo clinical assessments, lumbar punctures, venepuncture, biomarker blood analysis and cognitive assessment throughout the course of the study. (clinicaltrials.gov)
  • Thus, ambroxol, an oral available drug on the market, may be a safe option for GD patients with potential disease-specific efficacy and should be expanded into a clinical trial using higher doses and placebo-controlled design. (clinicaltrials.gov)
  • A Phase II clinical trial of Ambroxol has recently been completed and the results of this study should be published very shortly. (cureparkinsons.org.uk)
  • This week pre-clinical data was published demonstrating that the Ambroxol is active in the brain. (scienceofparkinsons.com)
  • Ambroxol also had activity against SARS CoV2 in Vero E6 cells, although the mechanism of action is not yet known. (wikipedia.org)
  • Since researchers know that the protein is transferred out of cells with the help of a process called exocytosis, researchers also examined whether ambroxol impacted the transportation mechanism. (gaucherdiseasenews.com)
  • Our organization, Shreeji Pharma International, is noted amongst the pioneer manufacturers, exporters and suppliers of high quality Ambroxol Hydrochloride . (shreejiexports.net)
  • What is the dosage of Ambroxol? (medindia.net)
  • What is the recommended dosage of Ambroxol? (internationaldrugmart.com)
  • The dosage of Ambroxol prescribed to each patient will vary. (internationaldrugmart.com)
  • A simple, economical, accurate, and precise method for simultaneous estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in tablet dosage form has been developed. (hindawi.com)
  • Hence, the proposed method can be employed for quantitative estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride from their tablet dosage form. (hindawi.com)
  • In WO 00/38653 described improved dosage form intended for transdermal administration of corticosteroids, and along with many other antioxidants also mentioned Ambroxol as excipients, suitable for protection against oxidative decomposition. (russianpatents.com)
  • Over dosage, application frequency, and treatment duration of ambroxol hydrochloride and glucose infusions should not be exceeded. (advacarepharma.com)
  • Ambroxol also enhances lung levels of a wide range of antibiotics. (wikipedia.org)
  • In case of acute bronchitis, Ambroxol should be paired with necessary antibiotics. (alldaygeneric.com)
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  • This occurs by diffusion of ambroxol into lysosomes and lysosomal pH neutralization. (wikipedia.org)
  • The acidic lysosomal environment provokes ambroxol dissassociation, leaving the enzyme free to function normally. (guidetopharmacology.org)
  • Thus by encouraging lysosomes to undergo exocytosis and spit their contents out of the cell - digested or not - Ambroxol allows the cell to remove waste effectively and therefore function in a more normal fashion. (scienceofparkinsons.com)
  • Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research. (medchemexpress.com)
  • Ambroxol hydrochloride is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia and bronchospasm asthma. (livestrong.com)
  • Whether a congestion generated in this best place to buy ambroxol uk has the warmth of affecting the hood in any great round i cannot presume not to determine. (therefinedfeline.com)
  • Ambroxol - a chest congestion and cough medicine that's being investigated for the treatment of Gaucher disease - has several molecular mechanisms in addition to acting as an enhancer of the enzyme that's lacking in Gaucher patients. (gaucherdiseasenews.com)
  • Rare reports of allergic reactions to Ambroxol have been reported. (knoji.com)
  • Avoid Ambroxol in case any allergic reactions occur. (knoji.com)
  • Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. (wikipedia.org)
  • As environmental pollution and population aging intensify, the incidence of respiratory diseases will keep rising, it is expected that Ambroxol will still have some growth potential in China in the next few years. (pharmiweb.com)
  • Ambroxol is used to treat respiratory diseases associated with thick mucus production (including emphysema with bronchitis, tracheobronchitis, bronchiectasis, bronchitis with bronchospasm, asthma) and other lung diseases such as pneumoconiosis and chronic inflammatory pulmonary conditions. (internationaldrugmart.com)
  • With the degradation of environmental pollution, the incidence of respiratory diseases is expected to keep increasing, so does the market size of ambroxol in China in the next few years. (researchmoz.us)
  • Ambroxol hydrochloride and glucose infusions are used in the treatment of respiratory diseases which include all forms of tracheobronchitis, emphysema with bronchitis pneumoconiosis, chronic inflammatory pulmonary conditions, bronchiectasis, and bronchitis with bronchospasm asthma. (advacarepharma.com)
  • Ambroxol is a commonly used treatment for respiratory diseases (the respiratory system being the lungs and related components required for breathing). (scienceofparkinsons.com)