Ambenonium Chloride
The generation of nerve and muscle repetivie activity in the rat phrenic nerve-diaphragm preparation following inhibition of cholinesterase by ecothiopate. (1/3)
1 Simultaneous extracellular recordings were made from two end-plate zones of the isolated diaphragm and from the phrenic nerve of the rat in response to stimulation of the nerve. The contractions of the diaphragm were also recorded.2 In the curarized diaphragm, the introduction of ecothiopate, a non-competitive inhibitor of cholinesterase, caused a threefold increase in the amplitude of the end-plate current and an eightfold increase in the duration at half the peak amplitude.3 In the non-curarized diaphragm, the introduction of ecothiopate caused the generation of repetitive activity (RA) in first the phrenic nerve: this was then followed by RA in the diaphragm. At that stage, nerve RA possessed a shorter latency than muscle RA. The generation time for nerve RA was 1.6 ms and for mRA, it was 2.7 milliseconds.4 Nerve RA was more labile than muscle RA; it was readily abolished by increasing the frequency of stimulation, by magnesium, by tubocurarine or by high concentrations of ecothiopate, whereas muscle RA was still generated. Steady exposure to acetylcholine abolished both forms of RA.5 Two competitive inhibitors of cholinesterase, neostigmine and ambenonium, were also shown to evoke RA in nerve and muscle. The generation times for nerve RA and muscle RA were similar to those following ecothiopate.6 It was concluded that nerve RA and muscle RA were generated after the inhibition of cholinesterase by ecothiopate as a result of the prolonged action of acetylcholine upon cholinoceptive sites on the nerve terminal and motor endplate respectively. A direct excitatory action of ecothiopate upon the phrenic nerve terminals was excluded. (+info)Thymoma, myasthenia gravis, erythroblastopenic anemia and systemic lupus erythematosus in one patient. (2/3)
A 50-year-old woman who initially had myasthenia gravis subsequently presented with thymoma, erythroblastopenic anemia and systemic lupus erythematosus during 17 years of follow-up. In a review of the literature no similar documented cases were found, although 14 patients were reported with three of the above diseases, two also having positive LE cell tests. An association of several autoimmune disorders in one patient may be more frequent than was previously believed. (+info)The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion. (3/3)
1. Surplus acetylcholine (ACh) is the extra ACh that accumulates in cholinergic nerve endings when they are exposed to an anticholinesterase agent. The synthesis and turnover of this ACh was examined in the cat's superior cervical ganglion.2. Surplus ACh did not accumulate in chronically decentralized ganglia perfused with eserine-choline-Locke solution, and this shows that it is stored in presynaptic nerve terminals.3. Surplus ACh accumulated more rapidly in ganglia perfused with eserine than in ganglia perfused with neostigmine or with ambenonium; accumulation was delayed by 45-60 min when a quaternary anticholinesterase was used. However, the release of ACh upon preganglionic nerve stimulation was the same during perfusion with eserine, neostigmine or ambenonium. It is concluded that intracellular acetylcholinesterase normally destroys surplus ACh, whereas extracellular enzyme destroys released ACh.4. When ganglia were perfused with [(3)H]choline and eserine, the surplus ACh that accumulated was labelled but its specific radioactivity was only 38% of that of the choline added to the perfusion fluid.5. Surplus ACh was not released by nerve stimulation and was not mobilized for release during, or after, prolonged nerve stimulation. It is concluded that ACh released by nerve impulses is replaced by synthesis at the site of ACh storage and not by movement of ACh from the surplus pool.6. The accumulation of surplus ACh no more than doubled the total ACh content of ganglia, but turnover of ACh continued when the total amount was constant. Surplus ACh may contribute to spontaneous ACh output from eserinized preparations.7. When ganglia were perfused with a medium containing high K(+) (56 mM), surplus ACh was released. (+info)
Ambenonium Chloride oral tablets
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Ambenonium chloride
Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor used in the management of myasthenia ... Ambenonium is used to treat muscle weakness due to disease or defect of the neuromuscular junction (myasthenia gravis). ... "Ambenonium". St. Elizabeth Healthcare. Archived from the original on 2015-09-08. Retrieved 2016-02-10. v t e (Articles with ... Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn ...
List of MeSH codes (D02)
... ambenonium chloride MeSH D02.092.877.096.040 - benzalkonium compounds MeSH D02.092.877.096.082 - benzethonium MeSH D02.092. ... ambenonium chloride MeSH D02.675.276.080 - benzalkonium compounds MeSH D02.675.276.090 - benzethonium MeSH D02.675.276.102 - ... methyl chloride MeSH D02.455.526.439.642 - methylene chloride MeSH D02.455.526.439.659 - mirex MeSH D02.455.526.439.681 - ... picryl chloride MeSH D02.640.529.880.900 - trinitrobenzenesulfonic acid MeSH D02.640.600.200 - 5-amino-3-((5-nitro-2-furyl) ...
List of drugs: Am
... ambenonium chloride (INN) ambenoxan (INN) Ambenyl Ambi 10 ambicromil (INN) Ambien (Sanofi-Aventis), also known as zolpidem ...
Ambenonium Chloride - MedsChat
Featuring active ingredients, dosages, related medications, and Ambenonium Chloride forums. ... Home › Drugs: A › Ambenonium Chloride Ambenonium Chloride. Category: Myasthenic Syndrome. Ambenonium (as ambenonium dichloride ... 2-PAM Chloride (Protopam Chloride OR pralidoxime chloride) for injection for RSD. Can anyone tell me if this has been used for ... Pot Chloride 10 Meq Ercap Pad White. I think I have a pot chloride 10meq ercap pad which is yellow and am wondering if it is ...
Galantamine: MedlinePlus Drug Information
Pediapred (prednisolone sodium phosphate) dose, indications, adverse effects, interactions... from PDR.net
Annexes nationales de médicaments - ANORP
Myasthenia Gravis Medication: Anticholinesterase Inhibitors, Corticosteroids, Immunomodulators, Immune Globulins, Monoclonal...
DeCS
Ambenonium Chloride - Preferred Concept UI. M0000853. Scope note. A quaternary ammonium compound that is an inhibitor of ... Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) ... Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) ... 4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride [D02.675.276.210] (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl ...
Code System Concept
Nalfon (fenoprofen calcium) dose, indications, adverse effects, interactions... from PDR.net
Ambenonium Chloride: (Moderate) NSAIDs may cause additive pharmacodynamic GI effects with cholinesterase inhibitors, leading to ... strontium-89 chloride, and thrombolytic agents. In addition, large doses of salicylates (>= 3-4 g/day) can cause ... strontium-89 chloride, and thrombolytic agents. In addition, large doses of salicylates (>= 3-4 g/day) can cause ... strontium-89 chloride, and thrombolytic agents. In addition, large doses of salicylates (>= 3-4 g/day) can cause ...
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Ambenonium Chloride: (Major) The muscarinic actions of ambenonium chloride can antagonize the antimuscarinic actions of ... Potassium Chloride: (Moderate) Use anticholinergics, such as scopolamine, and concomitant solid oral dosage forms of potassium ... Anticholinergics may decrease gastric motility and increase the transit time of solid oral dosage forms of potassium chloride ... Anticholinergics may decrease gastric motility and increase the transit time of solid oral dosage forms of potassium chloride ...
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MeSH Browser
Ambenonium Chloride [D02.675.276.046] * Benzalkonium Compounds [D02.675.276.080] * Benzethonium [D02.675.276.090] * Bephenium ... Benzalkonium Chloride Narrower Concept UI. M0002322. Registry Number. 8001-54-5. Terms. Benzalkonium Chloride Preferred Term ... Alkyldimethylbenzylammonium Chloride Asepsol BTC-2125 Benzalkonium Benzalkonium Chloride Drapolene Germex Osvan Zephiran Pharm ... 84; was BENZALKONIUM 1981-83, was BENZALKONIUM CHLORIDE 1968-80, was BENZALKONIUM CHLORIDE see under ANTI-INFECTIVE AGENTS, ...
National Ambulatory Medical Care Survey, 1994
BENZALKONIUM CHLORIDE 50516 BENZENE 50518 BENZESTROL 50520 BENZETHONIUM CHLORIDE 50525 BENZIN 50530 BENZOCAINE 50538 BENZOIC ... AMBENONIUM 50175 AMCINONIDE 50178 AMDINOCILLIN 50180 AMIKACIN 50182 AMILORIDE 50183 AMINACRINE 50185 AMINO ACIDS 50190 ... CHLORIDE ION 51066 CHLORMEZANONE 51068 CHLOROACETIC ACID 51070 CHLOROALLYHEXAMINIUM CHLORIDE 51075 CHLOROBUTANOL 51080 ... TUBOCURARINE CHLORIDE 32710 TUCKS 32735 TUMS 32770 TUSS-ORNADE 32800 TUSSAR DM 32825 TUSSEND 32840 TUSSI-ORGANIDIN DM 32845 ...
Hemicholinium 3 | Profiles RNS
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RESULTS: A group of known AChE inhibitors, such as donepezil, ambenonium dichloride, and tacrine hydrochloride, as well as many ... potassium chloride). Moreover, the distributions of altered metabolomic features were largely comparable with those observed ... previously unreported AChE inhibitors, such as chelerythrine chloride and cilostazol, were identified in this study. Many of ...
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R&D 货号: 0756/50 50 mg SIN-1 chloride (50 MG) SIN-1 chloride (50 mg) 1204 Tocris Small Molecules PG777 Tocris ¥2,072.14 ... R&D 货号: 0388/10 10 mg Ambenonium dichloride (10 MG) Ambenonium dichlorid (10 mg) 1204 Tocris Small Molecules PG777 Tocris ¥ ... R&D 货号: 0388/50 50 mg Ambenonium dichloride (50 MG) Ambenonium dichlorid (50 mg) 1204 Tocris Small Molecules PG777 Tocris ¥ ... R&D 货号: 0504/10 10 mg Diphenyleneiodonium chloride (10 MG) Diphenyleneiodonium (10 mg) 1204 Tocris Small Molecules PG777 Tocris ...
Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione: Uses, Interactions, Mechanism...
Ambenonium. The therapeutic efficacy of Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)- ... mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. Gene ... pyrimidinedione can be decreased when used in combination with Ambenonium.. Amitriptyline. The risk or severity of adverse ... mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.. Gene ...
Neostigmine
... is made by first reacting 3-dimethylaminophenol with N-dimethylcarbamoyl chloride, which forms a dimethylcarbamate ... Ambenonium • Donepezil • Edrophonium • Galantamine • Huperzine A • Minaprine • Tacrine • Zanapezil. Irreversible: ... is made by reacting 3-dimethylaminophenol with N-dimethylcarbamoyl chloride, which forms the dimethylcarbamate, and its ...
Myobloc (rimabotulinumtoxinB) dosing, indications, interactions, adverse effects, and more
sodium sulfate/?magnesium sulfate/potassium chloride. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride ... such as ambenonium, pyridostigmine), quinidine. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out ... sodium sulfate/?magnesium sulfate/potassium chloride. sodium sulfate/?magnesium sulfate/potassium chloride increases effects of ...
Botulinum toxin
While botulinum toxin is generally considered safe in a clinical setting, there can be serious side effects from its use. Most commonly, botulinum toxin can be injected into the wrong muscle group or spread from the injection site, causing paralysis of unintended muscles.. Side effects from cosmetic use generally result from unintended paralysis of facial muscles. These include partial facial paralysis, muscle weakness, and trouble swallowing. Side effects are not limited to direct paralysis however, and can also include headaches, flu-like symptoms, and allergic reactions.[33] Just as cosmetic treatments only last a number of months, paralysis side-effects can have the same durations. At least in some cases, these effects are reported to dissipate in the weeks after treatment. Bruising at the site of injection is not a side effect of the toxin but rather of the mode of administration, and is reported as preventable if the clinician applies pressure to the injection site; when it occurs, it is ...
Código ATC: N05 (PSICOLÉPTICOS) « PR Vademécum España
rede semántica multilingue : MA4974077 (inglês-inglês)
... chloride - chloruria - choana - object choice - chol-, chole-, cholo- - cholagogue - cholemia - choluria - cholangiectasis - ... ambenonium - ambi- - ambidexter - ambivalence - ambiversion - ambly- - amblyacousia - amblychromasia - Amblyomma - amblyoscope ... low-chloride diet - decibel - decidual - deciduosarcoma - decigram, deciliter, decimeter - decimolar - decinormal - infectious ...
Dictionnaire analogique multilingue : MA4974077 (français-anglais)
... ambenonium - ambi- - ambi- - ambidexter - ambidextre - ambivalence - ambivalence - ambiversion - ambiversion - ambly- - ambly- ... chloride - chlorure - chloruria - chlorurie - choana - choanes - object choice - choix dobjet - chol-, chole-, cholo- - chol ... low-chloride diet - déchloruré - decibel - décibel - decidual - décidual - deciduosarcoma - déciduosarcome - decigram, ...
Mytelase1
- Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor[1] used in the management of myasthenia gravis. (medschat.com)
Myasthenia gravis2
- 2] Mechanism of action Ambenonium exerts its actions against myasthenia gravis by competitive reversible inhibition of acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine. (medschat.com)
- Ambenonium is given by mouth in the treatment of myasthenia gravis. (bvsalud.org)
Neostigmine2
- An intermediate-acting agent, it is preferred in clinical use to the shorter-acting neostigmine bromide and the longer-acting ambenonium chloride. (medscape.com)
- Neostigmine is made by first reacting 3-dimethylaminophenol with N-dimethylcarbamoyl chloride, which forms a dimethylcarbamate. (en-academic.com)
MYTELASE2
- MYTELASE, brand of ambenonium chloride, is [Oxalylbis (iminoethylene)] bis[( o -chlorobenzyl) diethylammonium] dichloride, a white crystalline powder, soluble in water to 20 percent (w/v). (nih.gov)
- MYTELASE should also not be administered to patients with a known hypersensitivity to ambenonium chloride or any other ingredients of MYTELASE. (nih.gov)
Atropine2
- Because pralidoxime chloride is less effective in relieving depression of the respiratory center, atropine is always required concomitantly to block the effect of accumulated acetylcholine at this site. (nih.gov)
- Pralidoxime chloride relieves muscarinic signs and symptoms, salivation, bronchospasm, etc., but this action is relatively unimportant since atropine is adequate for this purpose. (nih.gov)
Treatment2
- Regardless of whether or not animal studies suggest that the organophosphate poison to which a particular patient has been exposed is amenable to treatment with pralidoxime chloride, the use of pralidoxime chloride should, nevertheless, be considered in any life-threatening situation resulting from poisoning by these compounds, since the limited and arbitrary conditions of pharmacologic screening do not always accurately reflect the usefulness of pralidoxime chloride in the clinical situation. (nih.gov)
- There are no adequate and well controlled clinical studies that establish the effectiveness of pralidoxime chloride as a treatment for poisoning with organophosphates having anticholinesterase activity. (nih.gov)
Patients1
- In one study of healthy adult volunteers and patients self-poisoned with organophosphate compounds, a single intramuscular injection of 1000 mg of pralidoxime chloride resulted in mean peak plasma levels of 7.5 ± 1.7 µg/mL and 9.9 ± 2.4 µg/mL, respectively. (nih.gov)