A quaternary ammonium compound that is an inhibitor of cholinesterase activity with actions similar to those of NEOSTIGMINE, but of longer duration. Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112)
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.

The generation of nerve and muscle repetivie activity in the rat phrenic nerve-diaphragm preparation following inhibition of cholinesterase by ecothiopate. (1/3)

1 Simultaneous extracellular recordings were made from two end-plate zones of the isolated diaphragm and from the phrenic nerve of the rat in response to stimulation of the nerve. The contractions of the diaphragm were also recorded.2 In the curarized diaphragm, the introduction of ecothiopate, a non-competitive inhibitor of cholinesterase, caused a threefold increase in the amplitude of the end-plate current and an eightfold increase in the duration at half the peak amplitude.3 In the non-curarized diaphragm, the introduction of ecothiopate caused the generation of repetitive activity (RA) in first the phrenic nerve: this was then followed by RA in the diaphragm. At that stage, nerve RA possessed a shorter latency than muscle RA. The generation time for nerve RA was 1.6 ms and for mRA, it was 2.7 milliseconds.4 Nerve RA was more labile than muscle RA; it was readily abolished by increasing the frequency of stimulation, by magnesium, by tubocurarine or by high concentrations of ecothiopate, whereas muscle RA was still generated. Steady exposure to acetylcholine abolished both forms of RA.5 Two competitive inhibitors of cholinesterase, neostigmine and ambenonium, were also shown to evoke RA in nerve and muscle. The generation times for nerve RA and muscle RA were similar to those following ecothiopate.6 It was concluded that nerve RA and muscle RA were generated after the inhibition of cholinesterase by ecothiopate as a result of the prolonged action of acetylcholine upon cholinoceptive sites on the nerve terminal and motor endplate respectively. A direct excitatory action of ecothiopate upon the phrenic nerve terminals was excluded.  (+info)

Thymoma, myasthenia gravis, erythroblastopenic anemia and systemic lupus erythematosus in one patient. (2/3)

A 50-year-old woman who initially had myasthenia gravis subsequently presented with thymoma, erythroblastopenic anemia and systemic lupus erythematosus during 17 years of follow-up. In a review of the literature no similar documented cases were found, although 14 patients were reported with three of the above diseases, two also having positive LE cell tests. An association of several autoimmune disorders in one patient may be more frequent than was previously believed.  (+info)

The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion. (3/3)

1. Surplus acetylcholine (ACh) is the extra ACh that accumulates in cholinergic nerve endings when they are exposed to an anticholinesterase agent. The synthesis and turnover of this ACh was examined in the cat's superior cervical ganglion.2. Surplus ACh did not accumulate in chronically decentralized ganglia perfused with eserine-choline-Locke solution, and this shows that it is stored in presynaptic nerve terminals.3. Surplus ACh accumulated more rapidly in ganglia perfused with eserine than in ganglia perfused with neostigmine or with ambenonium; accumulation was delayed by 45-60 min when a quaternary anticholinesterase was used. However, the release of ACh upon preganglionic nerve stimulation was the same during perfusion with eserine, neostigmine or ambenonium. It is concluded that intracellular acetylcholinesterase normally destroys surplus ACh, whereas extracellular enzyme destroys released ACh.4. When ganglia were perfused with [(3)H]choline and eserine, the surplus ACh that accumulated was labelled but its specific radioactivity was only 38% of that of the choline added to the perfusion fluid.5. Surplus ACh was not released by nerve stimulation and was not mobilized for release during, or after, prolonged nerve stimulation. It is concluded that ACh released by nerve impulses is replaced by synthesis at the site of ACh storage and not by movement of ACh from the surplus pool.6. The accumulation of surplus ACh no more than doubled the total ACh content of ganglia, but turnover of ACh continued when the total amount was constant. Surplus ACh may contribute to spontaneous ACh output from eserinized preparations.7. When ganglia were perfused with a medium containing high K(+) (56 mM), surplus ACh was released.  (+info)

Ambenonium Chloride is a medication that belongs to the class of anticholinesterase agents. It works by blocking the breakdown of acetylcholine, a neurotransmitter in the brain that is important for memory and thinking. This results in an increase in the level of acetylcholine in the brain, which can help to improve symptoms of certain types of dementia, such as Alzheimer's disease.

Ambenonium Chloride is available in tablet form and is typically taken two to three times a day. The medication may cause side effects such as nausea, vomiting, diarrhea, increased saliva production, and muscle cramps. It should be used with caution in people with certain medical conditions, such as asthma, heart disease, or seizure disorders, and should not be taken by people who are pregnant or breastfeeding.

It is important to note that Ambenonium Chloride is not a cure for dementia, but rather a treatment that can help to manage symptoms. It is usually used in combination with other therapies, such as cognitive stimulation and behavioral interventions, to provide the best possible outcomes for people with dementia.

Chlorides are simple inorganic ions consisting of a single chlorine atom bonded to a single charged hydrogen ion (H+). Chloride is the most abundant anion (negatively charged ion) in the extracellular fluid in the human body. The normal range for chloride concentration in the blood is typically between 96-106 milliequivalents per liter (mEq/L).

Chlorides play a crucial role in maintaining electrical neutrality, acid-base balance, and osmotic pressure in the body. They are also essential for various physiological processes such as nerve impulse transmission, maintenance of membrane potentials, and digestion (as hydrochloric acid in the stomach).

Chloride levels can be affected by several factors, including diet, hydration status, kidney function, and certain medical conditions. Increased or decreased chloride levels can indicate various disorders, such as dehydration, kidney disease, Addison's disease, or diabetes insipidus. Therefore, monitoring chloride levels is essential for assessing a person's overall health and diagnosing potential medical issues.

Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor used in the management of myasthenia ... Ambenonium is used to treat muscle weakness due to disease or defect of the neuromuscular junction (myasthenia gravis). ... "Ambenonium". St. Elizabeth Healthcare. Archived from the original on 2015-09-08. Retrieved 2016-02-10. v t e (Articles with ... Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn ...
... ambenonium chloride MeSH D02.092.877.096.040 - benzalkonium compounds MeSH D02.092.877.096.082 - benzethonium MeSH D02.092. ... ambenonium chloride MeSH D02.675.276.080 - benzalkonium compounds MeSH D02.675.276.090 - benzethonium MeSH D02.675.276.102 - ... methyl chloride MeSH D02.455.526.439.642 - methylene chloride MeSH D02.455.526.439.659 - mirex MeSH D02.455.526.439.681 - ... picryl chloride MeSH D02.640.529.880.900 - trinitrobenzenesulfonic acid MeSH D02.640.600.200 - 5-amino-3-((5-nitro-2-furyl) ...
... ambenonium chloride (INN) ambenoxan (INN) Ambenyl Ambi 10 ambicromil (INN) Ambien (Sanofi-Aventis), also known as zolpidem ...
Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor used in the management of myasthenia ... Ambenonium is used to treat muscle weakness due to disease or defect of the neuromuscular junction (myasthenia gravis). ... "Ambenonium". St. Elizabeth Healthcare. Archived from the original on 2015-09-08. Retrieved 2016-02-10. v t e (Articles with ... Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. This, in turn ...
Be sure to mention any of the following: ambenonium chloride (Mytelase); amitriptyline (Elavil); anticholinergic medications ...
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Acetylcholine chloride (JP18/USP/INN). D01000 Bethanechol chloride (JP18/USP). D01001 Ambenonium chloride (JP18/INN). ...
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4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride. *Ambenonium Chloride. *Benzalkonium Compounds. * ...
Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium chloride,. Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, ... Cholinesterase reactivator: Pralidoxime chloride.. *Cholinergic Blocking agents: SAR of cholinolytic agents. Solanaceous ...
Ambenonium Ambenonium chloride Amber Amber jewel Amber lily Amber oil Amber varnish ...
As an antagonist to such anticholinesterases as neostigmine, pyridostigmine, and ambenonium, which are used in the treatment of ... Available in the United States as PROTOPAM Chloride for Injection (PROTOPAM Chloride), pralidoxime chloride is frequently ... PROTOPAM (pralidoxime chloride) for Injection. DESCRIPTION. Chemical name: 2-formyl-1-methylpyridinium chloride oxime. ... Pralidoxime chloride is not bound to plasma protein.. Pralidoxime chloride is relatively short acting and repeated doses may be ...
Ambenonium Chloride [D02.675.276.046] * Benzalkonium Compounds [D02.675.276.080] * Benzethonium [D02.675.276.090] * Bephenium ... Tubocurarine Chloride Narrower Concept UI. M0022138. Registry Number. 900961Z8VR. Terms. Tubocurarine Chloride Preferred Term ... Tubocurarine Chloride d-Tubocurare d-Tubocurarine Pharm Action. Neuromuscular Nondepolarizing Agents. Nicotinic Antagonists. ...
BENZALKONIUM CHLORIDE 50516 BENZENE 50518 BENZESTROL 50520 BENZETHONIUM CHLORIDE 50525 BENZIN 50530 BENZOCAINE 50538 BENZOIC ... AMBENONIUM 50175 AMCINONIDE 50178 AMDINOCILLIN 50180 AMIKACIN 50182 AMILORIDE 50183 AMINACRINE 50185 AMINO ACIDS 50190 ... CHLORIDE ION 51066 CHLORMEZANONE 51068 CHLOROACETIC ACID 51070 CHLOROALLYHEXAMINIUM CHLORIDE 51075 CHLOROBUTANOL 51080 ... TUBOCURARINE CHLORIDE 32710 TUCKS 32735 TUMS 32770 TUSS-ORNADE 32800 TUSSAR DM 32825 TUSSEND 32840 TUSSI-ORGANIDIN DM 32845 ...
4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride. *Ambenonium Chloride. *Benzalkonium Compounds. * ...
4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride. *Ambenonium Chloride. *Benzalkonium Compounds. * ... Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity. Ocul Surf. 2022 ... The Effects of Latanoprost With Benzalkonium Chloride Versus Travoprost With SofZia on the Ocular Surface. Eye Contact Lens. ...
Betaine is a naturally occurring trimethyl ammonium compound
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Ambenonium Chloride [D02.675.276.046] * Benzalkonium Compounds [D02.675.276.080] * Benzethonium [D02.675.276.090] * Bephenium ...
Ambenonium Chloride (Rec.INN) * Amfetamine (Rec.INN) * Amifampridine (Rec.INN) *previous. *1 ...
Edrophonium Chloride (Tensilon) B. Irreversible blockers i. Pralidoxime Chloride ii. Echothiophate - Structure, Properties, ... or ambenonium. It is used as an antiarrhythmic drug in paroxymal atrial tachycardia. It is also used in the diagnosis of ... Properties and uses: It exists as a white crystalline powder, soluble in water and alcohol, insoluble in methylene chloride. On ...
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ambenonium chloride. 10 mg Dispense in tight, light-resistant. container as defined in theUSP/NF. ... MYTELASE, brand of ambenonium chloride, is [Oxalylbis (iminoethylene)] bis[(o-chlorobenzyl) diethylammonium] dichloride, a ... MYTELASE should also not be administered to patients with a known hypersensitivity to ambenonium chloride or any other ... Pralidoxime chloride may be used to alleviate these effects at the nicotinic receptors since pralidoxime has its most critical ...
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Ambenonium Chloride(Cholinesterase inhibitor.). *Amber. *Ambergris. *Amberlite®. *Amberlyst 15®. *Ambrisentan(Antihypertensive. ...
Ambenonium chloride (substance). Code System Preferred Concept Name. Ambenonium chloride (substance). Concept Status. Published ...
use AMBENONIUM CHLORIDE to search AMBESTIGMINUM 1977-94. History Note. 65; AMBESTIGMINUM was see AMBENONIUM CHLORIDE 1977-94. ... Ambenonium Chloride Preferred Term Term UI T001672. Date01/01/1999. LexicalTag NON. ThesaurusID ... Ambenonium Chloride Preferred Concept UI. M0000853. Registry Number. 51FOB87G3I. Related Numbers. 115-79-7. Scope Note. A ... Ambenonium Chloride. Tree Number(s). D02.092.877.096.019. D02.675.276.046. Unique ID. D000549. RDF Unique Identifier. http://id ...
use AMBENONIUM CHLORIDE to search AMBESTIGMINUM 1977-94. History Note. 65; AMBESTIGMINUM was see AMBENONIUM CHLORIDE 1977-94. ... Ambenonium Chloride Preferred Term Term UI T001672. Date01/01/1999. LexicalTag NON. ThesaurusID ... Ambenonium Chloride Preferred Concept UI. M0000853. Registry Number. 51FOB87G3I. Related Numbers. 115-79-7. Scope Note. A ... Ambenonium Chloride. Tree Number(s). D02.092.877.096.019. D02.675.276.046. Unique ID. D000549. RDF Unique Identifier. http://id ...
Ambenonium Chloride - Preferred Concept UI. M0000853. Scope note. A quaternary ammonium compound that is an inhibitor of ... Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) ... Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) ... 4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride [D02.675.276.210] (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl ...
Ambenonium chloride. *Methacholine. *Carbachol. Access More Pharmacology Resources Here. Cholinergic and anticholinergic drugs ...
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Abbreviations: AMBC, ambenonium chloride; CSR, complete stable remission; MGFA, Myasthenia Gravis Foundation of America; PB, ... Abbreviations: AMBC, ambenonium chloride; AZT, azathioprine; CT, chemotherapy; CT, computed tomography; F, female; IVIG, ...
Drugs to be Discontinued: Mytelase (Ambenonium Chloride) Tuesday, 26 June 2012 119 Current Drug Shortages: Epinephrine 1mg/mL ( ...
4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride. *Ambenonium Chloride. *Benzalkonium Compounds. * ...
Ambenonium chloride. *Ambucetamide. *AMG-1. *AMG-3. *AMG-36. *AMG-41. *Aminomethylbenzoic acid ...
AUTONOMIC AGENTS AMBENONIUM CHLORIDE AUTONOMIC AGENTS AMINOPHYLLINE AUTONOMIC AGENTS AMPHETAMINE AUTONOMIC AGENTS ANTIEMETICS ... CHOLINERGIC AGENTS AMBENONIUM CHLORIDE CHOLINERGIC AGENTS ARECOLINE CHOLINERGIC AGENTS ARMIN CHOLINERGIC AGENTS ATRACURIUM ... ENZYME INHIBITORS AMBENONIUM CHLORIDE ENZYME INHIBITORS AMINO ACID CHLOROMETHYL KETONES ENZYME INHIBITORS AMINOGLUTETHIMIDE ... NEUROTRANSMITTERS AND NEUROTRANSMITTER AMBENONIUM CHLORIDE NEUROTRANSMITTERS AND NEUROTRANSMITTER AMINO ACID NEUROTRANSMITTERS ...
In this study, a rapid, sensitive and selective method was developed for the fluorescence detection of ambenonium chloride (AC ...
Results: A group of known AChE inhibitors, such as donepezil, ambenonium dichloride, and tacrine hydrochloride, as well as many ... previously unreported AChE inhibitors, such as chelerythrine chloride and cilostazol, were identified in this study. Many of ...
As an antagonist to such anticholinesterases as neostigmine, pyridostigmine, and ambenonium, which are used in the treatment of ... Available in the United States as PROTOPAM Chloride for Injection (PROTOPAM Chloride), pralidoxime chloride is frequently ... PROTOPAM CHLORIDE- pralidoxime chloride injection, powder, lyophilized, for solution. To receive this label RSS feed. Copy the ... Pralidoxime chloride is not bound to plasma protein.. Pralidoxime chloride is relatively short acting and repeated doses may be ...
sodium sulfate/?magnesium sulfate/potassium chloride. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride ... such as ambenonium, pyridostigmine), quinidine. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out ... sodium sulfate/?magnesium sulfate/potassium chloride. sodium sulfate/?magnesium sulfate/potassium chloride increases effects of ...
trospium chloride. Monitor Closely (1)onabotulinumtoxinA and trospium chloride both decrease cholinergic effects/transmission. ... such as ambenonium, pyridostigmine), quinidine. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out ... trospium chloride. onabotulinumtoxinA and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor ... sodium sulfate/?magnesium sulfate/potassium chloride. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride ...
... consisting primarily of water as well as a smaller amount of sodium chloride (the main constituent of table salt), that is ...
N04AB02: orfenadrina (cloruro) - orphenadrine (chloride) *N04AC: Ésteres de tropina o derivados de la tropina - Ethers of ... N07AA30: ambenonio - ambenonium *N07AA51: neostigmina, combinaciones con - neostigmine, combinations *N07AB: Ésteres de la ...
  • Ambenonium (as ambenonium dichloride, trade name Mytelase) is a cholinesterase inhibitor used in the management of myasthenia gravis. (wikipedia.org)
  • MYTELASE, brand of ambenonium chloride, is [Oxalylbis (iminoethylene)] bis[( o -chlorobenzyl) diethylammonium] dichloride, a white crystalline powder, soluble in water to 20 percent (w/v). (nih.gov)
  • MYTELASE should also not be administered to patients with a known hypersensitivity to ambenonium chloride or any other ingredients of MYTELASE. (nih.gov)
  • Ambenonium exerts its actions against myasthenia gravis by competitive reversible inhibition of acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine. (wikipedia.org)
  • Ambenonium is used to treat muscle weakness due to disease or defect of the neuromuscular junction (myasthenia gravis). (wikipedia.org)
  • Ambenonium is given by mouth in the treatment of myasthenia gravis. (nih.gov)
  • Pralidoxime chloride is a cholinesterase reactivator. (nih.gov)
  • The principal action of pralidoxime chloride is to reactivate cholinesterase (mainly outside of the central nervous system) which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound. (nih.gov)
  • Pralidoxime chloride also slows the process of "aging" of phosphorylated cholinesterase to a nonreactivatable form, and detoxifies certain organophosphates by direct chemical reaction. (nih.gov)
  • Each vial contains 1000 mg of sterile pralidoxime chloride, and sodium hydroxide to adjust pH, to be reconstituted with 20 mL of Sterile Water for Injection, USP. (nih.gov)
  • Perspiration (also called sweating or sometimes transpiration) is the production and evaporation of a fluid, consisting primarily of water as well as a smaller amount of sodium chloride (the main constituent of table salt ), that is excreted by the sweat glands in the skin of mammals . (wikidoc.org)
  • Because pralidoxime chloride is less effective in relieving depression of the respiratory center, atropine is always required concomitantly to block the effect of accumulated acetylcholine at this site. (nih.gov)
  • Pralidoxime chloride relieves muscarinic signs and symptoms, salivation, bronchospasm, etc., but this action is relatively unimportant since atropine is adequate for this purpose. (nih.gov)
  • PROTOPAM Chloride has been studied in animals as an antidote against numerous organophosphate pesticides, chemicals, and drugs (see Animal Pharmacology and Toxicology ). (nih.gov)
  • Regardless of whether or not animal studies suggest that the organophosphate poison to which a particular patient has been exposed is amenable to treatment with pralidoxime chloride, the use of pralidoxime chloride should, nevertheless, be considered in any life-threatening situation resulting from poisoning by these compounds, since the limited and arbitrary conditions of pharmacologic screening do not always accurately reflect the usefulness of pralidoxime chloride in the clinical situation. (nih.gov)
  • There are no adequate and well controlled clinical studies that establish the effectiveness of pralidoxime chloride as a treatment for poisoning with organophosphates having anticholinesterase activity. (nih.gov)
  • In one study of healthy adult volunteers and patients self-poisoned with organophosphate compounds, a single intramuscular injection of 1000 mg of pralidoxime chloride resulted in mean peak plasma levels of 7.5 ± 1.7 µg/mL and 9.9 ± 2.4 µg/mL, respectively. (nih.gov)
  • Ambenonium reversibly binds acetylcholinesterase, inactivates it and therefore increases levels of acetylcholine. (wikipedia.org)
  • Pralidoxime chloride occurs as an odorless, white, nonhygroscopic, crystalline powder which is soluble in water. (nih.gov)
  • The chloride is preferred because of physiologic compatibility, excellent water solubility at all temperatures, and high potency per gram, due to its low molecular weight. (nih.gov)