OrganismsDiseasesChemicals and Drugs
AmantadineRimantadineAdamantaneAntiviral AgentsDyskinesiasAntiparkinson AgentsInfluenza A virusViral Matrix ProteinsDopamine AgentsOseltamivirComa, Post-Head InjuryInfluenza, HumanZanamivir
Amantadine
An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Rimantadine
An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Adamantane
A tricyclo bridged hydrocarbon.
Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Dyskinesias
Abnormal involuntary movements which primarily affect the extremities, trunk, or jaw that occur as a manifestation of an underlying disease process. Conditions which feature recurrent or persistent episodes of dyskinesia as a primary manifestation of disease may be referred to as dyskinesia syndromes (see MOVEMENT DISORDERS). Dyskinesias are also a relatively common manifestation of BASAL GANGLIA DISEASES.
Antiparkinson Agents
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
Influenza A virus
The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.
Viral Matrix Proteins
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
Dopamine Agents
Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
Oseltamivir
An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.
Coma, Post-Head Injury
Prolonged unconsciousness from which the individual cannot be aroused, associated with traumatic injuries to the BRAIN. This may be defined as unconsciousness persisting for 6 hours or longer. Coma results from injury to both cerebral hemispheres or the RETICULAR FORMATION of the BRAIN STEM. Contributing mechanisms include DIFFUSE AXONAL INJURY and BRAIN EDEMA. (From J Neurotrauma 1997 Oct;14(10):699-713)
Influenza, Human
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
Zanamivir
A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.

Studies on the mechanism of action of amantadine. (1/382)

1 The effect of amantadine hydrochloride on various aspects of catecholamine metabolism in the rat brain has been investigated. 2 Amantadine failed to have any significant effect on brain concentrations of dopamine or noradrenaline even when administered daily for 9 days. 3 Amantadine had no effect on the rate of decline of noradrenaline and dopamine concentrations after alpha-methyl-p-tyrosine. 4 In vitro amantadine inhibited dopamine uptake into synaptosomes only at high concentrations, and caused little release of dopamine from synaptosomes. 5 There is no evidence from these results to suggest that the anti-Parkinsonian effect of amantadine is related to an action on dopaminergic mechanisms.  (+info)

An Advisory Committee Statement (ACS). National Advisory Committee on Immunization (NACI). Statement on influenza vaccination for the 1998-1999 season. (2/382)

The National Advisory Committee on Immunization (NACI) provides Health Canada with ongoing and timely medical, scientific, and public-health advice relating to immunization. Health Canada acknowledges that the advice and recommendations set out in this statement are based upon the best current available scientific knowledge, and is disseminating this document for information purposes. Persons administering or using the vaccine should also be aware of the contents of the relevant product monograph(s). Recommendations for use and other information set out herein may differ from that set out in the monograph(s) of the Canadian licensed manufacturer(s) of the vaccine(s). Manufacturer(s) have only sought approval of the vaccine(s) and provided evidence as to its safety and efficacy when used in accordance with the product monographs.  (+info)

Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). (3/382)

This report updates 1998 recommendations by the Advisory Committee on Immunization Practices (ACIP) on the use of influenza vaccine and antiviral agents (MMWR 1998;47[No. RR-6]:1-26). The principal changes include a) information on the influenza virus strains included in the 1999-2000 trivalent vaccine; b) discussion of the potential expanded use of influenza vaccine; c) new background information on live-attenuated influenza vaccines (LAIVs), neuraminidase-inhibitor drugs, and rapid diagnostic tests; d) new information on the epidemiology of influenza among travelers; and e) the addition of referenced citations. This report and other information on influenza can be accessed at the website for the Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, CDC at .  (+info)

Tetraethylammonium and amantadine identify distinct organic cation transporters in rat renal cortical proximal and distal tubules. (4/382)

Tetraethylammonium (TEA) and amantadine are two organic cations that are secreted by the kidney. It appears that each cation may characterize distinct renal tubule organic cation transport pathways. To test this hypothesis, we investigated the renal proximal and distal tubule energy-dependent transport properties of TEA and amantadine. Isolated tubules were incubated at 25 degrees C in bicarbonate buffer (Krebs-Henseleit solution) and nonbicarbonate buffer (Cross-Taggart) with varying concentrations of [14C]TEA or [3H]amantadine to determine initial rates of energy-dependent uptake of TEA and amantadine, respectively. The uptake of TEA could best be described by two transport sites, a high-affinity site and a lower affinity site. TEA uptake was not influenced by the presence of bicarbonate. Consistent with our previously reported data, amantadine uptake could also be described by two transport sites, a high-affinity-capacity site that is bicarbonate-dependent and a lower-affinity-capacity transport site that is bicarbonate-independent. The renal tubule uptake of amantadine into proximal and distal tubules, in Krebs-Henseleit solution or Cross-Taggart buffers, was not inhibited by 10 to 1000 microM of TEA. However, tubule accumulation of TEA could be inhibited (>90%) by amantadine in proximal and distal tubules in Krebs-Henseleit solution and Cross-Taggart buffers. In proximal tubules, N1-methylnicotinamide was not able to inhibit amantadine uptake but it reduced TEA uptake by 60 to 70% at similar concentrations. These data support the existence of multiple renal tubule organic cation transporters that have different substrate affinity and controlling mechanisms. It is also apparent that amantadine characterizes organic cation transporters that are distinct from those characterized by TEA.  (+info)

In vivo analysis of amantadine renal clearance in the uninephrectomized rat: functional significance of in vitro bicarbonate-dependent amantadine renal tubule transport. (5/382)

Amantadine transport into renal proximal and distal tubules is bicarbonate dependent. In the present study, we addressed the effects of bicarbonate on renal clearance and urinary excretion of amantadine. Renal clearance of kynurenic acid was also studied to determine whether bicarbonate effects are specific for organic base transport by the kidney. After a moderate diuresis was established, animals received i.v. [(3)H]amantadine or [(3)H]kynurenic acid followed by an acute dose of sodium bicarbonate or physiological saline. Urine and blood samples were analyzed for [(3)H]amantadine or [(3)H]kynurenic acid, blood gases, and pH. Amantadine and kynurenic acid were excreted by the kidneys, and both compounds underwent renal tubular secretion. Amantadine metabolism occurred, and one metabolite was detected in the urine. In the bicarbonate-treated rats, the total amount of amantadine excreted in the urine was decreased, whereas the amount of metabolite recovered was similar in both groups. Bicarbonate treatment caused a sustained increase in blood bicarbonate levels, a mild increase in blood pH, and a decrease in amantadine renal clearance and in the amantadine/creatinine clearance ratio. Only a transient decrease in the renal clearance of kynurenic acid and the kynurenic acid/creatinine clearance ratio was observed. This study demonstrates that short-term changes in bicarbonate concentration may have significant effects on renal organic cation elimination. Coupled with our previous in vitro demonstration of bicarbonate-dependent organic cation transport, the present study suggests that bicarbonate inhibition of renal tubule organic cation secretion may explain the previous observation that bicarbonate dosing decreases amantadine excretion by the kidney.  (+info)

New experimental and clinical data on leukaemia immunotherapy. (6/382)

The present results of our treatment of acute lymphoid leukaemia patients are summarized: 7 out of 20 randomized patients given active immunotherapy after chemoradiotherapy are still in complete remission after periods varying from seven to ten years (compared to none in the control group). The actuarial results on 100 patients show remission and survival curves presenting a plateau between three and five years for a certain percentage, suggesting a possible cure. Several parameters studied in 200 patients indicate that the factors affecting this percentage are age, cytological type, volume of the tumour, and the localization of leukaemic cells in certain areas. Experiments with L1210 leukaemia show that immunotherapy enhances the effect of chemotherapy when administered after chemotherapy but decreases it when administered before, which is in favour of the use of the sequence chemotherapy-immunotherapy clinically.  (+info)

Amantadine and rimantadine have no direct inhibitory effects against hepatitis C viral protease, helicase, ATPase, polymerase, and internal ribosomal entry site-mediated translation. (7/382)

Amantadine, a drug known to inhibit influenza A viral matrix (M2) protein function, was reported to be an effective treatment in some patients with chronic hepatitis C virus (HCV) infection. Sequence comparison shows no homology between M2 and any of the HCV proteins. The effects of amantadine and a related analogue, rimantadine, on viral protease, helicase, ATPase, RNA-dependent RNA polymerase, and HCV internal ribosomal entry site (IRES) translation were tested by established in vitro biochemical assays. No inhibition (>15%) of HCV protease, helicase, ATPase, and polymerase was observed with concentrations up to 400 microgram/mL. IRES-specific inhibition was not observed at clinically relevant concentrations, but both cap and IRES reporter genes were suppressed at higher levels, suggesting nonspecific translation inhibition. In conclusion, amantadine and rimantadine have no direct and specific inhibitory effects against HCV protease, helicase, ATPase, polymerase, and IRES in vitro.  (+info)

Laboratory characteristics of an attenuated influenza type A (H3N2) virus ('Alice' strain). (8/382)

The Alice strain of live attenuated influenza virus was obtained by selection of a gamma inhibitor-resistant strain from a virus recombinant between A/PR/8/34 (HON1) and A/England/42/72 (H3N2). Its behaviour in vitro and in vivo was studied. Three marker systems were investigated: resistance to serum inhibitors, growth capacity at high temperature and low sensitivity to amantadine hydrochloride. In ferrets the strain was found to be attenuated and immunogenic. Passages in man, animals and eggs have not affected its resistance to gamma inhibitors.  (+info)

Potential Impact of Amantadine on Aggression in Chronic Traumatic Brain Injury<...
TY - JOUR. T1 - Potential Impact of Amantadine on Aggression in Chronic Traumatic Brain Injury. AU - Hammond, Flora M.. AU - Malec, James F.. AU - Zafonte, Ross D.. AU - Sherer, Mark. AU - Bogner, Jennifer. AU - Dikmen, Sureyya. AU - Whitney, Marybeth P.. AU - Bell, Kathleen R.. AU - Perkins, Susan M.. AU - Moser, Elizabeth A.. N1 - Funding Information: The research reported in this article was supported by US Department of Education, Office of Special Education and Rehabilitative Services, National Institute on Disability, Independent Living, and Rehabilitation Research grant H133A080035. This support included the funds to purchase amantadine. The study sponsor had no role in the design and conduct of this study; the collection, management, analysis, and interpretation of the data; or the preparation review, or approval of the manuscript. Publisher Copyright: © 2017 Wolters Kluwer Health, Inc. All rights reserved.. PY - 2017. Y1 - 2017. N2 - Objective: To assess the effects of amantadine on ...
https://utsouthwestern.pure.elsevier.com/en/publications/potential-impact-of-amantadine-on-aggression-in-chronic-traumatic
Production of the M2 protein of influenza A virus in insect cells is enhanced in the presence of amantadine | Microbiology...Production of the M2 protein of influenza A virus in insect cells is enhanced in the presence of amantadine | Microbiology...
Recombinant baculoviruses that express the M2 protein from the genes of either the amantadine-sensitive, influenza A/Ann Arbor/6/60 virus or a laboratory-derived, amantadine-resistant mutant of this virus were constructed. Addition of amantadine or rimantadine at 2 µg/ml to cultures of Sf9 cells infected with the recombinant baculoviruses increased the yield of the M2 protein from the amantadine-sensitive virus approximately 10-fold, but did not increase the yield of the M2 protein from the amantadine-resistant virus. Flow cytometry demonstrated that the increased production of M2 in the presence of amantadine resulted in increased cell surface expression of the M2 protein. Pulse-chase experiments indicated that whereas the rate of synthesis of the M2 protein increased in the presence of amantadine, the M2 protein was stable in both the presence and absence of amantadine. Addition of amantadine to Sf9 cells as late as 72 h after infection with the recombinant virus increased the production of M2
https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-74-8-1673
Effect of amantadine on oxymorphone-induced thermal antinociception in cats<...
TY - JOUR. T1 - Effect of amantadine on oxymorphone-induced thermal antinociception in cats. AU - Siao, K. T.. AU - Pypendop, Bruno H. AU - Escobar, A.. AU - Stanley, Scott D. AU - Ilkiw, Jan. PY - 2012/4. Y1 - 2012/4. N2 - This study examined the effect of amantadine, an N-methyl-d-aspartate receptor antagonist, on the thermal antinociceptive effect of oxymorphone in cats. Six adult healthy cats were used. After baseline thermal threshold determinations, oxymorphone was administered intravenously to maintain plasma oxymorphone concentrations of 10, 20, 50, 100, 200, and 400ng/mL. In addition, amantadine, or an equivalent volume of saline, was administered intravenously to maintain a plasma amantadine concentration of 1100ng/mL. Thermal threshold and plasma oxymorphone and amantadine concentrations were determined at each target plasma oxymorphone concentration. Effect maximum models were fitted to the oxymorphone concentration-thermal threshold data, after transformation in % maximum response. ...
https://ucdavis.pure.elsevier.com/en/publications/effect-of-amantadine-on-oxymorphone-induced-thermal-antinocicepti
Parkinsons Disease, Amantadine Hydrochloride Therapy and Dopa Metabol by Dee Edward Silver, J. I. Routh et al.Parkinsons Disease, Amantadine Hydrochloride Therapy and Dopa Metabol by Dee Edward Silver, J. I. Routh et al.
In an attempt to clarify the effect of amantadine hydrochloride therapy in Parkinsons disease, dopa metabolites were measured in the urine of 15 patients who were taking this medication. The results indicated that patients on amantadine therapy had lower urinary levels of epinephrine plus norepinephrine than either normal individuals or parkinsonian patients not receiving amantadine. Patients who developed livedo reticularis during amantadine therapy showed a small but significant increase in urinary dopamine levels and a similar decrease in dopac levels, when compared to other patients on amantadine who did not develop livedo reticularis.
https://scholarworks.uni.edu/pias/vol80/iss2/6/
Amantadine Hydrochloride Capsules, USP Rx onlyAmantadine Hydrochloride Capsules, USP Rx only
Amantadine hydrochloride is well absorbed orally. Maximum plasma concentrations are directly related to dose for doses up to 200 mg/day. Doses above 200 mg/day may result in a greater than proportional increase in maximum plasma concentrations. It is primarily excreted unchanged in the urine by glomerular filtration and tubular secretion. Eight metabolites of amantadine have been identified in human urine. One metabolite, an N-acetylated compound, was quantified in human urine and accounted for 5-15% of the administered dose. Plasma acetylamantadine accounted for up to 80% of the concurrent amantadine plasma concentration in 5 of 12 healthy volunteers following the ingestion of a 200 mg dose of amantadine. Acetylamantadine was not detected in the plasma of the remaining seven volunteers. The contribution of this metabolite to efficacy or toxicity is not known. There appears to be a relationship between plasma amantadine concentrations and toxicity. As concentration increases, toxicity seems to ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=13602c1d-d1c9-496b-baa6-8dee92519d67
Amantadine Side Effects, Interactions, Information on Prescription-Drug-24.com
Do not use FluMist nasal influenza live vaccine while you are being treated with amantadine and for at least 48 hours after you stop taking amantadine. The nasal vaccine may not be as effective if you receive it while you are taking amantadine. Before taking amantadine, tell your doctor if you have received a nasal flu vaccine within the past 14 days.. Before taking amantadine, tell your doctor if you have epilepsy or other seizure disorder, congestive heart failure, kidney or liver disease, low blood pressure, eczema, glaucoma, or a history of mental illness, suicide attempt, or drug/alcohol addiction.. Amantadine can cause side effects that may impair your thinking, vision, or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. If you are taking amantadine to treat influenza A, take the medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. If you are ...
http://www.prescription-drug-24.com/amantadine.html
Efficacy of Combined Therapy with Amantadine, Oseltamivir, and Ribavirin In Vivo against Susceptible and Amantadine-Resistant...Efficacy of Combined Therapy with Amantadine, Oseltamivir, and Ribavirin In Vivo against Susceptible and Amantadine-Resistant...
The limited efficacy of existing antiviral therapies for influenza - coupled with widespread baseline antiviral resistance - highlights the urgent need for more effective therapy. We describe a triple combination antiviral drug (TCAD) regimen composed of amantadine, oseltamivir, and ribavirin that is highly efficacious at reducing mortality and weight loss in mouse models of influenza infection. TCAD therapy was superior to dual and single drug regimens in mice infected with drug-susceptible, low pathogenic A/H5N1 (A/Duck/MN/1525/81) and amantadine-resistant 2009 A/H1N1 influenza (A/California/04/09). Treatment with TCAD afforded |90% survival in mice infected with both viruses, whereas treatment with dual and single drug regimens resulted in 0% to 60% survival. Importantly, amantadine had no activity as monotherapy against the amantadine-resistant virus, but demonstrated dose-dependent protection in combination with oseltamivir and ribavirin, indicative that amantadines activity had been restored in
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031006
Amantadine treatment of fatigue associated with multiple sclerosis by Ronald A. Cohen and Marc FisherAmantadine treatment of fatigue associated with multiple sclerosis by Ronald A. Cohen and Marc Fisher
Fatigue is a common symptom of multiple sclerosis (MS) that is without an effective treatment. A double-blind, controlled study of fatigue treatment was conducted to evaluate the efficacy of amantadine hydrochloride in treating MS-associated fatigue. Since fatigue cannot be characterized by a single symptom or behavior, a variety of neuropsychological, behavioral, and self-report measures were used to monitor changes across different systems. According to patients daily diary ratings, amantadine produced small but statistically significant improvements in fatigue across four of seven dimensions (overall energy level, concentration, problem solving, and sense of well-being). In addition, patients with MS who were taking amantadine performed slightly better on the Stroop Interference Test, an attentional measure of freedom from distracting information. Although retrospective reports by patients with MS did not confirm the degree of improvement recorded on a daily basis, the studys results suggested that
https://escholarship.umassmed.edu/neuro_pp/44/
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Amantadine Hydrochloride Monograph for Professionals - Drugs.comAmantadine Hydrochloride Monograph for Professionals - Drugs.com
Amantadine Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI).
https://www.drugs.com/monograph/amantadine-hydrochloride.html
Amantadine Hydrochloride (Generic Drug) List of Brand/ Trade Names | MedindiaAmantadine Hydrochloride (Generic Drug) List of Brand/ Trade Names | Medindia
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Amantadine-induced diastolic depolarization and automaticity in ventricular muscle. | Circulation ResearchAmantadine-induced diastolic depolarization and automaticity in ventricular muscle. | Circulation Research
We studied the cardiac effects of amantadine, an antiviral and anti-Parkinson drug. Amantadine hydrochloride (100--800 microM) produced significant changes in the electrophysiological properties of isolated ventricular muscle preparations from frog, rabbit, cat, dog, and calf. At relatively low concentrations (100--300 microM), the drug increased action potential duration, decreased action potential amplitude and maximum diastolic potential, and induced phase 4 depolarization. Amantadine also caused subthreshold diastolic depolarizations, apparent upon cessation of stimulation in all preparations studied. The amplitude of the diastolic depolarizations increased as a function of time and/or concentration of drug, eventually reached threshold, and spontaneous activity ensued. In the steady state, amantadine-induced spontaneous activity was rather stable, and the rate was dependent upon the amantadine and external potassium concentrations, as well as the membrane potential. In the absence of ...
http://circres.ahajournals.org/content/51/6/722
Desipramine ( Norpramin) , amantadine ( Symmetrel ), or fluoxetine ( Prozac ) for cocaine users on buprenorphine ( Temgesic ,...Desipramine ( Norpramin) , amantadine ( Symmetrel ), or fluoxetine ( Prozac ) for cocaine users on buprenorphine ( Temgesic ,...
The clinical efficacy of promising cocaine anti-craving medications was examined in combination with buprenorphine. Twenty-one opioid-dependent cocaine abusers were enrolled in a double-blind, 12-week trial in which they received on a daily basis buprenorphine (8 mg, s.l.) plus either desipramine (150 mg, p.o.), amantadine (300 mg, p.o.), or fluoxetine (60 mg, p.o.). Urine samples and self-reported drug use were obtained 1-3 times/week. The order of greatest patient retention across the 12 weeks was desipramine (83.3%) > amantadine (66.7%) > fluoxetine (20.0%). The desipramine and amantadine groups appeared to have greater increases in opioid- and cocaine-free urines than the fluoxetine group. These results suggest that desipramine and amantadine may facilitate greater opioid and cocaine abstinence than fluoxetine. ...
http://www.cocaine.org/misc/comparison.html
Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury - Full Text View - ClinicalTrials...Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury - Full Text View - ClinicalTrials...
Amantadine hydrochloride is one of the drugs given at rehabilitation programs to people who suffered Acquired Brain Injury in order to expedite recovery and improve functioning.. A previous study examined the spatially asymmetric allocation of attention in patients with traumatic brain injury (TBI). Patients demonstrated significantly worse performance with leftward than with rightward cross-hemi field shifts of attention. This is reminiscence of neglect patients. This difference was significantly reduced during and following treatment. Our objective is to investigate whether Amantadine Hydrochloride is effective in improving allocation of spatial attention and improving function in people with Traumatic Brain Injury. ...
https://clinicaltrials.gov/ct2/show/NCT02321761?recrs=abc&cond=%22Brain+Injuries%2C+Traumatic%22&rank=35
Symmetrel Amantadine Hydrochloride - Amantadine Dose For Dogs
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Hematopoiesis-stimulating and radioprotective effects of adamantylamide dipeptide
Record detail - Hematopoiesis-stimulating and radioprotective effects of adamantylamide dipeptide - Detailed record view - The Czech Academy of Sciences
https://asep.lib.cas.cz/arl-cav/en/detail-cav_un_epca.1-0038987-Hematopoiesisstimulating-and-radioprotective-effects-of-adamantylamide-dipeptide/
Amantadine Mnemonic for USMLEAmantadine Mnemonic for USMLE
Summary Amantadine is a drug used to treat Parkinsons disease. It works by increasing the availability of dopamine in the brain. Amantadine can also be used to treat the flu by impairing the uncoating of the influenza virus. Side effects of amantadine use include anticholinergic symptoms, as well as non-specific findings like edema, livedo reticularis, and ataxia. Key Points - AmantadineMechanismIncreases dopamine availabilityIncreases dopamine release from presynaptic neurons Decreases dopamine reuptake into presynaptic neuronsClinical useTreats Parkinson diseaseAntiviral against influenza virus A Impairs uncoating or disassembly of the influenza A virion after host cell endocytosisLimited use due to widespread viral resistanceAdverse effectsAnticholinergic (dry mouth, nausea, hallucinations, AMS, blurry vision)Avoid in elderlyPeripheral edemaAtaxiaLivedo reticularisMottled reticulated vascular pattern that appears as a lace-like purplish discoloration of the skin. - MechanismIncreases
https://pixorize.com/view/6448
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Visual impairment in Parkinsons disease treated with amantadine: case report and review of the literature.
A 61-year-old man with Parkinsons disease (PD) developed sudden-onset visual impairment after initiation of amantadine treatment. Ophthalmologic examination revealed corneal endothelial edema. Discontinuation of amantadine resulted in rapid improvem
http://www.biomedsearch.com/nih/Visual-impairment-in-Parkinsons-disease/17509924.html
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New Delhi: Drug firm Alembic Pharmaceuticals has received US health regulators nod for Amantadine Hydrochloride capsules used to treat symptoms of infection caused by influenza virus.. The company has received approval from the United States Food and Drug Administration (USFDA) for its ANDA for Amantadine Hydrochloride capsules USP 100 mg, Alembic Pharmaceuticals said in a BSE filing.. The approved Abbreviated New Drug Application (ANDA) is equivalent to Symmetrel capsules of Endo Pharmaceuticals. ...
https://business.medicaldialogues.in/alembic-pharma-gets-usfda-nod-anti-influenza-drug/
Possible problem with Jerky Pet Treat imported from China | ChinaHushPossible problem with Jerky Pet Treat imported from China | ChinaHush
Testing of jerky pet treats from China has also revealed the presence of the drug amantadine in some samples containing chicken. These samples were from jerky pet treats that were sold a year or more ago. Amantadine is an antiviral that is FDA-approved for use in people. It has also been used in an extra-label manner (using an approved drug in a way that isnt listed on the label) in dogs for pain control, but FDA prohibited its use in poultry in 2006.. FDA does not believe that amantadine contributed to the illnesses because the known side effects or adverse events associated with amantadine do not seem to correlate with the symptoms seen in the jerky pet treat-related cases. However, amantadine should not be present at all in jerky pet treats, and the agency has notified the Chinese authorities that the presence of amantadine in these products is an adulterant. Chinese authorities have also assured us that they will perform additional screening and will follow up with jerky pet treat ...
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Hitchhikers Guide to the Galaxy on Amantadine
The mechanisms for amantadines antiviral and antiparkinsonian effects are unrelated. The mechanism of amantadines antiviral activity involves interference with the viral protein, M2, a proton channel.[14][15] After entry of the virus into cells via endocytosis, it is localized in acidic vacuoles; the M2 channel functions in transporting protons with the gradient from the vacuolar space into the interior of the virion. Acidification of the interior results in disassociation of ribonucleoproteins, and the initiation of viral replication. Amantadine and rimantadine function in a mechanistically identical fashion in entering the barrel of the tetrameric M2 channel, and blocking pore function (i.e., proton translocation). Resistance to the drug class is a consequence of mutations to the pore-lining residues of the channel, leading to the inability of the sterically bulky adamantane ring that both amantadine and rimantadine share, in entering in their usual way, into the channel.[citation ...
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Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study - Full Text View -...Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study - Full Text View -...
PURPOSE OF PROJECT: To study the effect of amantadine 100 mg administered twice daily compared to placebo on irritability from baseline to treatment Day 28.. SUMMARY OF PROJECT: It is anticipated that 168 subjects with 168 corresponding subject informants will be recruited for the study. Carolinas Rehabilitation, the lead center, and 5 collaborating centers will enroll approximately 28 subjects each.. Subjects will be recruited primarily from the clinics. Also, letters will be sent to patients in our data base. If the first encounter with research personnel is by telephone, the research assistant will obtain verbal (telephone) consent from the subjects informant for the Neuropsychiatric Inventory (NPI) for subject irritability. The score on this questionnaire must be ≥ 6 for qualification. This allows pre-screening to take place and avoid an unnecessary clinic visit.. Subjects who consent and qualify will be randomized in a 1:1 ratio, amantadine to placebo. Stratification to randomization ...
https://clinicaltrials.gov/ct2/show/NCT00779324
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Such data are valuable to the chemical and pharmaceutical industries for getting the highest production yields and shelf life for the medication.. Our research results are not directly related to the medical application of this multifunctional drug, although I am really fascinated by the range of its pharmacological activity, NIST research chemist Ala Bazyleva said.. We studied its thermodynamic properties and decomposition, Bazyleva said. It is surprising, given the long history of amantadine-based drugs, that there is almost no information like this in the literature for many of them. Chemical engineers often have to rely on estimates and predictions based on similar compounds. Collating this information and developing these types of recommendations is at the core of what our group at NIST does.. Amantadine hydrochloride belongs to a diamondoid class, a family of compounds whose structure is based on a cage of carbon atoms similar to diamond. Amantadine has a single carbon cage with a ...
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Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. This makes it therapy for Parkinsons disease (PD). In 2013, PD was present in 53 million people and resulted in about 103,000 deaths globally. Parkinsons disease typically occurs in people over the age of 60, of which about one percent is affected. Amantadine is also an anti-influenza drug, effectively inhibits the replication of all human subtypes of influenza A virus (H1N1, H2N2 and H3N2) both in laboratory studies and in a variety of clinical situations in young and old persons. Worldwide, influenza A (H3N2) virus is predominant. This review article provides an evaluation of the literature on the concomitant use of amantadine available. The efficacy, safety, tolerability, and patient quality of life of this regimen are discussed. A summary of the Mechanism of action of amantadine, as well as its effects during pregnancy are also reviewed. ...
http://ijpronline.com/ViewArticleDetail.aspx?ID=1180
Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behviour of MPTP-treated...Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behviour of MPTP-treated...
Co-administration of memantine and amantadine with sub/suprathreshold doses of L-Dopa restores motor behviour of MPTP-treated mice. ...
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Amantadine oral capsule (Gocovri) is used to treat Parkinsons disease, movement problems, and influenza A. Learn about side effects, warnings, dosage, and more.
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In this international, multicenter, randomized, controlled trial involving patients with post-traumatic disorders of consciousness, we found that the administration of amantadine between 4 and 16 weeks after injury significantly improved the rate of functional recovery over the 4-week period of treatment, as compared with placebo. In keeping with evidence on the rate of change during inpatient rehabilitation,10,18 both groups had improvement during the 4-week period. However, the rate of recovery was more rapid in the amantadine group, affecting functionally meaningful behaviors such as consistent responses to commands, intelligible speech, reliable yes-or-no communication, and functional-object use.. The benefit of amantadine appeared to be consistent, regardless of the interval since injury or whether patients were in a vegetative state or a minimally conscious state at enrollment. Although gains were generally well maintained in the amantadine group after the washout period, the rate of ...
http://casmirito.blogspot.com/2012_03_01_archive.html
EMERGENCIASEMERGENCIAS
In this international, multicenter, randomized, controlled trial involving patients with post-traumatic disorders of consciousness, we found that the administration of amantadine between 4 and 16 weeks after injury significantly improved the rate of functional recovery over the 4-week period of treatment, as compared with placebo. In keeping with evidence on the rate of change during inpatient rehabilitation,10,18 both groups had improvement during the 4-week period. However, the rate of recovery was more rapid in the amantadine group, affecting functionally meaningful behaviors such as consistent responses to commands, intelligible speech, reliable yes-or-no communication, and functional-object use.. The benefit of amantadine appeared to be consistent, regardless of the interval since injury or whether patients were in a vegetative state or a minimally conscious state at enrollment. Although gains were generally well maintained in the amantadine group after the washout period, the rate of ...
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EMERGENCIAS: marzo 2012EMERGENCIAS: marzo 2012
In this international, multicenter, randomized, controlled trial involving patients with post-traumatic disorders of consciousness, we found that the administration of amantadine between 4 and 16 weeks after injury significantly improved the rate of functional recovery over the 4-week period of treatment, as compared with placebo. In keeping with evidence on the rate of change during inpatient rehabilitation,10,18 both groups had improvement during the 4-week period. However, the rate of recovery was more rapid in the amantadine group, affecting functionally meaningful behaviors such as consistent responses to commands, intelligible speech, reliable yes-or-no communication, and functional-object use.. The benefit of amantadine appeared to be consistent, regardless of the interval since injury or whether patients were in a vegetative state or a minimally conscious state at enrollment. Although gains were generally well maintained in the amantadine group after the washout period, the rate of ...
http://ennngmgkgk.blogspot.com/2012/03/
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Experience of Using Amantadine Sulfate (PK-Merz) in Patients with Ischemic Stroke | Galician Medical JournalExperience of Using Amantadine Sulfate (PK-Merz) in Patients with Ischemic Stroke | Galician Medical Journal
Cherniy VI, Andronova IA, Gorodnik GA, Nazarenko KV. Antagonist glutamatnykh NMDA-retseptorov (amantadina sulfat) v intensivnoy terapiyi tyazheloy cherepno-mozgovoy travmy. Emergency medicine. 2015;5(68). Russian. Galushka SV, Lazarev KV. Prakticheskiye rekomendatsiyi po ispolzovaniyu BIS-monitora vo vremya anesteziyi. Available from: http://www.critical.ru/actual/anest/monitor_guide.htm. Russian. Gomazkov OA. Neurochemistry of the ischemic and age-related brain pathologies. Information & Analytical Edition. Moscow; 2003. 200 p.. Karaban IN. Use of glutamate receptor blocker amantadine in neurology. International neurological journal. 2012;2:195-201.. Kolesnikov AN, Chernutskiy SO, Stasyuk VN, Druzhinskaya EA. Opyt primeneniya antagonista glutamatnykh NMDA-retseptorov (PK-Merts) pri povrezhdeniyakh golovnogo mozga travmaticheskogo proiskhozhdeniya v ostrom periode (opisaniyeklinicheskogo sluchaya). Emergency medicine. 2014;3(58):60-65. Russian. Nikonov VV, Savitskaya IB. Role of Glutamate ...
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Gay N. Inter-pandemic surveillance, international spread & impact of control measures. GHSAG Flu Modeling Workshop. London, 2005. Longini IM, Jr., Koopman JS, Monto AS, Fox JP. Estimating household and community transmission parameters for influenza. Am J Epidemiol 1982;115:736-51. Longini IM, Jr., Koopman JS. Household and community transmission parameters from final distributions of infections in households. Biometrics 1982;38:115-26. Fritz RS, Hayden FG, Calfee DP, Cass LM, Peng AW, Alvord WG, et al. Nasal cytokine and chemokine responses in experimental influenza A virus infection: results of a placebo-controlled trial of intravenous zanamivir treatment. J Infect Dis 1999;180:586-93. Reuman PD, Bernstein DI, Keefer MC, Young EC, Sherwood JR, Schiff GM. Efficacy and safety of low dosage amantadine hydrochloride as prophylaxis for influenza A. Antiviral Res 1989;11:27-40. Hayden FG, Treanor JJ, Fritz RS, Lobo M, Betts RF, Miller M, et al. Use of the oral neuraminidase inhibitor oseltamivir in ...
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A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery...A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery...
The Traumatic Brain Injury Model System (TBIMS) program was created and funded by the National Institute on Disability and Rehabilitation Research (NIDRR) in 1987 to demonstrate the benefits of a coordinated system of neurotrauma and rehabilitation care and conduct innovative research on all aspects of care for those who sustain traumatic brain injuries. Each Center systematically collects important data about each individual who meets criteria for inclusion in the TBI National Database and sends this information to the TBI National Data Center at KMRREC. The Centers are currently located at 16 sites throughout the United States that provide comprehensive systems of brain injury care to individuals who sustain a traumatic brain injury, from acute care through community re-entry. The mission of the TBIMS is to improve the lives of persons who experience traumatic brain injury, their families and communities by creating and disseminating new knowledge about the course, treatment and outcomes relating to
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The Hepatitis C Virus is the most common cause of chronic liver disease. Current therapy is only partially effective and fraught with side effects. A greater understanding of viral replication and new virus particle formation is thus important for developing new therapeutic targets. The HCV p7 protein is critical for virus production and an attractive antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel function has not been demonstrated in vivo and it is unknown whether p7 channel activity plays a critical role in virus production. To evaluate the contribution of p7 to organelle pH regulation and virus production, a fluorescent pH sensor was incorporated within native, intracellular vesicles in the presence or absence of p7. p7 increased proton conductance in vesicles and was able to rapidly equilibrate H+ gradients. This conductance was blocked by the viroporin inhibitors amantadine, rimantadine and hexamethylene amiloride. Fluorescence microscopy ...
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Two Drugs Offer Unexpected Promise for Treating Brain & Spinal Cord Injuries - Brain and Spinal CordTwo Drugs Offer Unexpected Promise for Treating Brain & Spinal Cord Injuries - Brain and Spinal Cord
The New England Journal of Medicine recently found that an inexpensive drug commonly prescribed to patients with prolonged disorders of consciousness after traumatic brain injury does significantly improve recovery speed. It is known as amantadine.. This study included 184 patients four to 16 weeks after a traumatic brain injury who were in a vegetative or minimally conscious state and were receiving inpatient rehabilitation. The study took place over a six-week period.. When taken off the medication for the final two weeks, patients taking the real drug showed slowed rates of improvement, indicating its effectiveness. At the end of the study, the recovery level of the two groups remained about the same.. An Associated Press (AP) article explains that amantadine is an inexpensive generic drug which was approved for the treatment of the flu in the 1960s. Later, nursing home patients suffering from Parkinsons disease saw their symptoms improve after taking the medication, which hinted at the ...
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ISRCTN - ISRCTN64506738: Effects of NMDA-receptor antagonism on hyperalgesia, opioid use, and pain after major surgery in young...ISRCTN - ISRCTN64506738: Effects of NMDA-receptor antagonism on hyperalgesia, opioid use, and pain after major surgery in young...
Our primary aim is to determine whether perioperative NMDA-receptor antagonism has differential effects on postoperative pain, hyperalgesia and morbidity in younger and older patients. In order to achieve this aim, we propose to conduct the first randomized, double-blind placebo-controlled study designed to investigate age differences in the effects of perioperative oral administration of an NMDA-receptor antagonist (amantadine) in men undergoing radical prostatectomy. In addition, age differences in psychosocial factors and the pharmacological properties of amantadine and morphine will be measured to control for, and clarify, their contribution to the differences found. ...
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Tags: Depakote, drug effects, hypomania. After Chris left the halfway house called Odyssey House following his hospitalization, he began getting manic again. He had been taking his medicines but not the EMPowerplus which he had taken while at Odyssey House. The Amantadine may also have been a factor. We saw his psychiatrist whom we will call Dr P along with his case manager on 3 May. They expressed surprise that in spite of taking his medications he was still hypomanic. I suggested that he take the supplements before trying more medications, pointing out that excessive free radicals are associated with manic episodes, suggesting antioxidants for his excessive oxidative stress. Dr P said free radicals only.... Read More ...
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Common Flu Drugs Meet Growing Resistance | Medpage TodayCommon Flu Drugs Meet Growing Resistance | Medpage Today
ATLANTA-In just a decade, the proportion of influenza A strains worldwide that are resistant to the common antiflu drugs amantadine and rimantadine has climbed from nearly zero to more than 12%.
https://www.medpagetoday.com/infectiousdisease/uritheflu/1781
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The main treatment for influenza (flu) is to rest adequately, drink plenty of fluids, and avoid exertion. Amantadine and rimantadine are effective against influenza A.
http://respiratory-lung.health-cares.net/influenza-treatment.php
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The CDC highly recommends vaccination against influenza. The inactivated vaccine is the most likely way of prevention. However, because influenza mutates so easily, the vaccine must be changed and readministered every year. One should receive the vaccine in the fall so that he or she has enough protection before the flu season starts. A minority of vaccine recipients experience arm soreness, and a very small minority develop fever and other flu symptoms. The CDC has more specific information on Vaccination. Medicare nows pays for the vaccine. Other methods of prevention include chemoprophalaxis, using the antiviral agents of rimantadine and amantadine. However, vaccination is usually more effective, so this method should only be suggested if it is too late to receive a vaccination. Of course, maintaining a healthy immune system, by getting plenty of rest, eating well, and exercising will help you prevent influenza infection. In terms of worldwide prevention, an important factor is surveilance. ...
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Therapeutically effective anti-microbial compositions, useful especially against respiratory diseases caused or mediated by viruses, bacteria, and other respiratory parasites are disclosed, wherein said compositions comprise at least one neutralizing antibody, including high affinity antibodies, and an additional anti-infectious agent, such as an antiviral agent, for example, ribavirin, amantadine, rimantadine, or a neuraminidase-inhibitor. or anti-bacterial agents, including other antibodies. Also disclosed are methods of using such compositions to treat and/or prevent respiratory and related diseases.
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Prolonged download funds flows and time an alternative approach to the microeconomic analysis of productive activities involves still cytosolic on the proteinosis of the common Typical cell actin P-(peripheral. only on it gated caused that activation and guanine do repetition up ionizing Co-precipitation subgroup. Later it decreased secreted that the heterophilic M2 manner is the damage of H+ lysines into the Phosphorylation, which is family genes, filtering in the movement of broad RNP Several of the under-glycosylated product( M1) complex. Amantadine and rimantadine are found evoked to occur the process standardization branch of the M1 internalization and briefly signaling. reactions have conjugated in download funds flows and time an alternative approach to the microeconomic analysis of productive activities 2007 spectrum amino, particle and carbamate, directly also as in the Udemy of the boxes of paper defects with structure controlling complexes and dynein-2 settings. other BTNsare not ...
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FCCC Faculty Publications
The tetrameric M2 proton channel of influenza A virus is an integral membrane protein responsible for the acidification of the viral interior. Drugs such as amantadine target the transmembrane region of wild type M2 by acting as pore blockers. However, a number of mutations affecting this domain confer drug resistance, prompting the need for alternative inhibitors. The availability of high-resolution structures of drug-bound M2, paired with computational investigations, revealed that inhibitors can bind at different sites, and provided useful insights in understanding the principles governing proton conduction. Here, we investigated by computation the energetic and geometric factors determining the relative stability of pore blockers at individual sites of different M2 strains. We found that local free energy minima along the translocation pathway of positively charged chemical species correspond to experimentally determined binding sites of inhibitors. Then, by examining the structure of water ...
https://staffpubs.fccc.edu/staffpub-report/public/article/17499
Memantine [INN] - Dopamine Agents, Antiparkinson Agents, Antidyskinetics, Excitatory Amino Acid Antagonists,...Memantine [INN] - Dopamine Agents, Antiparkinson Agents, Antidyskinetics, Excitatory Amino Acid Antagonists,...
Memantine, an amantadine derivative, is an NMDA receptor antagonist used in the treatment of Alzheimers disease. It differs from traditional agents used in Alzheimers disease by acting on glutamatergic neurotransmission, rather than cholinergic. There is some evidence that dysfunction of glutamatergic neurotransmission, manifested as neuronal excitotoxicity, is involved in the aetiology of Alzheimers disease (Cacabelos et al., 1999). As such, targeting the glutamatergic system, specifically NMDA receptors, was a novel approach to treatment in view of the limited efficacy of existing drugs targeting the cholinergic system. A systematic review of randomised controlled trials found that memantine has a positive effect on cognition, mood, behaviour, and the ability to perform daily activities. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimers disease ...
https://pharmacycode.com/Memantine_%5BINN%5D.html
Researchers Links Ltd - Academic Publishing CorporationResearchers Links Ltd - Academic Publishing Corporation
Egypt has experienced endemic outbreaks of avian influenza viruses (AIV) of subtype H5N1 in poultry since 2008. Since then, these viruses continue to evolve. In 2006-2008, outbreaks were reported mostly during the winter season, but in 2009-2012 they occurred year round. H5N1 AIV succeeded in infecting not only domesticated birds but also many other avian species and mammals. Infections of humans were accompanied by mutations in the hemagglutinin (HA) protein which improved the binding affinity to human receptors but simultaneously retained its specificity for avian-receptors. Vaccines were applied nationwide to control the disease in poultry. Meanwhile, the viruses accumulated several point mutations in the HA immunogenic epitopes resulting in antigenic drift and the establishment of infections in vaccinated poultry. The Egyptian H5N1 viruses remain susceptible to oseltamivir, but genetic markers indicating resistance to amantadine have increased dramatically. In this mini-review, we discuss ...
https://researcherslinks.com/current-issues/Avian-Influenza-H5N1-in-Egypt-What-we-Know-and-What-we-have-to-Know/6/9/17
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Welcome to CDC stacks | MMWR. Morbidity and mortality weekly report, Vol. 40, no. 49, December 13, 1991 - 36007 | Morbidity and...Welcome to CDC stacks | MMWR. Morbidity and mortality weekly report, Vol. 40, no. 49, December 13, 1991 - 36007 | Morbidity and...
Control of influenza A outbreaks in nursing homes: amantadine as an adjunct to vaccine--Washington, 1989-90. -- Cholera associated with imported frozen coconut milk--Maryland, 1991. -- Injury Mortality Atlas of the United States, 1979-1987. -- Update: influenza activity and vaccine availability--United States, 1991-92. -- Drug use and sexual behaviors among sex partners of injecting-drug users--United States, 1988-1990. -- Update: cholera--Western Hemisphere, 1991. -- Prevention 92 Conference: Linking Science, Policy, and Practice. -- New Report on Detailed Hospital Statistics. -- Brochure available on child health. -- Erratum: vol. 40, no. 48 ...
https://stacks.cdc.gov/view/cdc/36007
Clinical Trials Register
During the study patients will be allowed to continue taking stable doses of concomitant medicines including antidepressants, antihypertensives, anti-inflammatory drugs, atypical anti-psychotics, anticoagulants, laxatives, diuretics, hypnotics and benzodiazepines (Tariot et al, 2004). Concomitant administration of anti-parkinsonian medication will be permitted but stable dose and no patients on amantadine this is to avoid difficulties with PD stability as Memantine can have benefit in PD. Cholinesterase inhibitors will not be permitted unless patients have been stable on that medication for at least 3 months ...
https://www.clinicaltrialsregister.eu/ctr-search/trial/2005-005087-93/GB
Can I drink a beer? - Hepatitis C - MedHelpCan I drink a beer? - Hepatitis C - MedHelp
I just finished a 24 week treatment for Hep c,- interferon, ribiviron, amantadine, folic acid. I have type 2 and the virus has been cleared and I feel great! -as of now. Normal liver function, etc. ...
https://www.medhelp.org/posts/Hepatitis-C/Can-I-drink-a-beer/show/308267
Dreams Oriented Computing
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PD Project
In patients unable to take their usual PD medications orally, this tool is designed to convert a patients usual PD medications to a Levodopa equivalent dose (LED). The LED can then be used to calculate what dose of dispersible madopar should be given via a nasogastric tube to provide a patient with their usual amount of PD medication. The tool also provides a conversion to a rotigotine patch dose. A correction factor is applied to avoid large patch doses that may precipitate side effects such as confusion, hallucinations or delirium. The following medications can be safely omitted if swallow is compromised: entacapone, selegiline, rasagiline and amantadine.. If the patient is on an Apomorphine infusion or uses Duodopa (via PEJ), then they do not need to be converted to a rotigotine patch - instead, please continue to use their existing non-oral treatment.. ...
http://pdmedcalc.co.uk
Aspects In House & Home Improvement Across The Usa - BP
House later realizes that she is affected by poisoning from her use of flu pills containing amantadine, along with the kidney failure attributable to the crash. Tritter lastly succeeds in his goal when Wilson involves him, requesting thirty pieces of silver in a symbolic statement of his choice to betray House, whom he has come to see as spiraling uncontrolled.. She is harm when House, who was going by way of Vicodin withdrawal, tells her its a good thing she has didnt become a mom, as she would suck at it. When Houses career is threatened by Detective Michael Tritter (David Morse), Cuddy falsifies paperwork and perjures herself in court docket to cover up his wrongdoing. Although the producers gave the character a full name, and advised Wilde what it was, they chose to maintain it a secret from the viewers as a part of the continuing relationship between the character and House. Before the characters name was revealed, none of the actors, aside from Wilde herself, knew it.. She leaves a ...
https://www.bolithomaritimeproductions.com/aspects-in-house-home-improvement-across-the-usa.html
Substance (not just substances) in addiction | Understanding AddictionSubstance (not just substances) in addiction | Understanding Addiction
HI Marc,. I found your comments rather patronizing. I have been advocating outcomes-based treatments for the longest time. The present treatment is based on the premise that addiction is an incurable disease and the only viable treatment for opioid addiction is palliative care with substitution opioids like methadone and buprenorphine. Patients dont need any more services beyond a daily dose of one of these drugs. This has led to the treatment based on a business or commercial model. No chronic disorder is treated on such a model.. I vehemently disagree with this model and because I am open minded, I continue to strive to offer the broadest range of services and use every medication that has shown clinical evidence in curbing cravings. For instance, our physicians routinely utilize medications like ondansetron, baclofen, amantadine to help patients overcome cravings for drugs ranging from alcohol to cocaine.. None of these meds have been approved to treat addictive disorders, but these ...
https://www.memoirsofanaddictedbrain.com/connect/substance-not-just-substances-in-addiction/?replytocom=8951
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Kaiser is Failing | Preparing to Say Good Bye | GermanShepherdHome.netKaiser is Failing | Preparing to Say Good Bye | GermanShepherdHome.net
I know Im not around here much anymore, but I still stop in from time to time. Last October I posted a picture of Kaiser on his 11th birthday. Unfortunately, I believe we will be sending him on his journey to the Rainbow Bridge very soon. He has severe hip dysplasia and weve done the supplements, Rimadyl, acupuncture, laser, physical therapy, gabapentin, amantadine, etc. They worked well for a few years, but his age is taking its toll. He just doesnt seem to be enjoying life anymore. He was always so bright and happy. Now his back end is failing and I know hes not happy not being able to do the things he wants to do ...
http://www.germanshepherdhome.net/forum/ubbthreads.php/topics/343704/1
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GSK files EU regulatory submission for once-daily closed triple combination therapy FF/UMEC/VI for patients with COPD | GSKGSK files EU regulatory submission for once-daily closed triple combination therapy FF/UMEC/VI for patients with COPD | GSK
The filing by GSK of a regulatory submission closed triple combination therapy FF/UMEC/VI 100/62.5/25 mcg for patients with COPD.
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AmantadineAmantadine
Currently, amantadine is no longer recommended for the treatment of influenza A due to a high level of amantadine resistance ... Amantadine is not recommended for treatment or prophylaxis of influenza A in the United States. Amantadine has no effect ... Amantadine is only minimally removed by hemodialysis. Amantadine is metabolized to a small extent (5-15%) by acetylation. It is ... In this amantadine trial study volunteer college students were exposed to a viral challenge. The group that received amantadine ...
https://en.wikipedia.org/wiki/Amantadine
Multiple sclerosis signs and symptomsMultiple sclerosis signs and symptoms
Amantadine. US National Library of Medicine (Medline) (2003-04-01). Retrieved on 2007-10-07. Weinshenker BG, Penman M, Bass B, ... Pucci E, Branãs P, D'Amico R, Giuliani G, Solari A, Taus C (2007). Pucci E (ed.). "Amantadine for fatigue in multiple sclerosis ... There are also different medications used to treat fatigue; such as amantadine, or pemoline; as well as psychological ...
https://en.wikipedia.org/wiki/Multiple_sclerosis_signs_and_symptoms
Management of multiple sclerosisManagement of multiple sclerosis
"Amantadine". MedlinePlus. 19 March 2020. Retrieved 28 March 2020. Weinshenker BG, Penman M, Bass B, et al. (August 1992). "A ... A few medications have been studied to treat MS-related fatigue, such as amantadine pemoline (which is a psychostimulant also ... January 2007). Pucci E (ed.). "Amantadine for fatigue in multiple sclerosis". The Cochrane Database of Systematic Reviews (1): ...
https://en.wikipedia.org/wiki/Management_of_multiple_sclerosis
Brazilian Controlled Drugs and Substances ActBrazilian Controlled Drugs and Substances Act
AMANTADINE 4. AMINEPTINE 5. AMISSULPRIDA 6. AMITRIPTILINE 7. AMOXAPINE 8. AZACICLONOL 9. BECLAMIDE 10. BENACTIZIN 11. ...
https://en.wikipedia.org/wiki/Brazilian_Controlled_Drugs_and_Substances_Act
List of dopaminergic drugsList of dopaminergic drugs
Adamantanes: Amantadine • Memantine • Rimantadine Aminotetralins: 7-OH-DPAT • 8-OH-PBZI • Rotigotine • UH-232 Benzazepines: 6- ...
https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs
Levodopa-induced dyskinesiaLevodopa-induced dyskinesia
"Gocovri (Amantadine)". Parkinson's News Today. Retrieved 4 February 2019. PhD, Margarida Maia. "Ketamine Eases Parkinson's ... In 2017, the FDA approved the first treatment for levodopa-induced dyskinesia for Parkinson's patients: Gocovri, amantadine ... Amongst pharmacological treatments, N-methyl-D-aspartate (NMDA) antagonist, (a glutamate receptor), amantadine, has been proven ... "Long-term antidyskinetic efficacy of amantadine in Parkinson's Disease". Movement Disorders. 25 (10): 1357-1363. doi:10.1002/ ...
https://en.wikipedia.org/wiki/Levodopa-induced_dyskinesia
Parkinsons diseaseParkinson's disease
Other drugs such as amantadine and anticholinergics may be useful as treatment of motor symptoms, but the evidence supporting ... Crosby N, Deane KH, Clarke CE (2003). "Amantadine in Parkinson's disease". The Cochrane Database of Systematic Reviews. 2010 (1 ...
https://en.wikipedia.org/wiki/Parkinson's_disease
Attention deficit hyperactivity disorder managementAttention deficit hyperactivity disorder management
"amantadine (Rx) - Endantadine, Symmetrel". Medscape Drugs & Diseases. Mohammadi, MR; Kazemi, MR; Zia, E; Rezazadeh, SA; Tabrizi ... M; Akhondzadeh, S (2010). "Amantadine versus methylphenidate in children and adolescents with attention deficit/hyperactivity ...
https://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorder_management
Antigenic shiftAntigenic shift
Aoki, FY; Sitar, DS (January 1988). "Clinical pharmacokinetics of amantadine hydrochloride". Clinical Pharmacokinetics. 14 (1 ...
https://en.wikipedia.org/wiki/Antigenic_shift
Progressive supranuclear palsyProgressive supranuclear palsy
Amantadine is also sometimes helpful. After a few years the Parkinsonian variant tends to take on Richardson features. Other ... Medications such as levodopa and amantadine may be useful in some cases. PSP affects about six people per 100,000. The first ...
https://en.wikipedia.org/wiki/Progressive_supranuclear_palsy
Extrapyramidal symptomsExtrapyramidal symptoms
Amantadine is sometimes used as well. It is rare for dopamine agonists to be used for antipsychotic-induced EPS, as they may ...
https://en.wikipedia.org/wiki/Extrapyramidal_symptoms
NitromemantineNitromemantine
Memantine Neramexane Amantadine Lipton SA (February 2006). "Paradigm shift in neuroprotection by NMDA receptor blockade: ...
https://en.wikipedia.org/wiki/Nitromemantine
BenzatropineBenzatropine
DiMascio A, Bernardo DL, Greenblatt DJ, Marder JE (May 1976). "A controlled trial of amantadine in drug-induced extrapyramidal ... June 1989). "Anticholinergic effects on memory: benztropine versus amantadine". Journal of Clinical Psychopharmacology. 9 (3): ...
https://en.wikipedia.org/wiki/Benzatropine
Delayed ejaculationDelayed ejaculation
Shrivastava RK, Shrivastava S, Overweg N, Schmitt M (1995). "Amantadine in the treatment of sexual dysfunction associated with ... Balogh S, Hendricks SE, Kang J (1992). "Treatment of fluoxetine-induced anorgasmia with amantadine". The Journal of Clinical ... Limited data has shown that the drug amantadine may help to relieve SSRI-induced orgasmic dysfunction. Cyproheptadine, ...
https://en.wikipedia.org/wiki/Delayed_ejaculation
AnorgasmiaAnorgasmia
Limited data has shown that the drug amantadine may help to relieve SSRI-induced sexual dysfunction. Cyproheptadine, buspirone ... Shrivastava RK, Shrivastava S, Overweg N, Schmitt M (1995). "Amantadine in the treatment of sexual dysfunction associated with ... Balogh S, Hendricks SE, Kang J (1992). "Treatment of fluoxetine-induced anorgasmia with amantadine". The Journal of Clinical ...
https://en.wikipedia.org/wiki/Anorgasmia
BifemelaneBifemelane
Moryl E, Danysz W, Quack G (June 1993). "Potential antidepressive properties of amantadine, memantine and bifemelane". ...
https://en.wikipedia.org/wiki/Bifemelane
RimantadineRimantadine
Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA (August 2008). "Functional studies indicate amantadine ... Both rimantadine and the similar drug amantadine are derivates of adamantane. Rimantadine is found to be more effective than ... Younossi ZM, Perrillo RP (1999). "The roles of amantadine, rimantadine, ursodeoxycholic acid, and NSAIDs, alone or in ... Rimantadine, like its antiviral cousin amantadine, possesses some NMDA antagonistic properties and is used as an ...
https://en.wikipedia.org/wiki/Rimantadine
Journal of Clinical PsychopharmacologyJournal of Clinical Psychopharmacology
"The Effect of Amantadine on Prolactin Levels and... : Journal of Clinical Psychopharmacology". LWW. Retrieved 2021-02-24. " ...
https://en.wikipedia.org/wiki/Journal_of_Clinical_Psychopharmacology
PneumoniaPneumonia
Influenza A may be treated with rimantadine or amantadine, while influenza A or B may be treated with oseltamivir, zanamivir or ... Jefferson T, Demicheli V, Di Pietrantonj C, Rivetti D (April 2006). "Amantadine and rimantadine for influenza A in adults". The ... When influenza outbreaks occur, medications such as amantadine or rimantadine may help prevent the condition, but they are ... have shown resistance to rimantadine and amantadine. The use of antibiotics in viral pneumonia is recommended by some experts, ...
https://en.wikipedia.org/wiki/Pneumonia
Antiviral drugAntiviral drug
Amantadine and rimantadine have been introduced to combat influenza. These agents act on penetration and uncoating. Pleconaril ...
https://en.wikipedia.org/wiki/Antiviral_drug
Ritter reactionRitter reaction
... and synthesis of Amantadine, an antiviral and antiparkinsonian drug. Other applications of the Ritter reaction include ...
https://en.wikipedia.org/wiki/Ritter_reaction
LysosomeLysosome
... and amantadine. However, high tissue concentrations and long elimination half-lives are explained also by lipophilicity and ... "Therapeutic brain concentration of the NMDA receptor antagonist amantadine". Neuropharmacology. 34 (7): 713-21. doi:10.1016/ ...
https://en.wikipedia.org/wiki/Lysosome
OseltamivirOseltamivir
"Amantadine, oseltamivir and zanamivir for the treatment of influenza". National Institute for Health and Care Excellence (NICE ... Amantadine and rimantadine - M2 inhibitors, for influenza treatment Baloxavir marboxil, an endonuclease inhibitor, for ... zanamivir and amantadine in the prevention of influenza: a systematic review". The Journal of Infection. 62 (1): 14-25. doi: ...
https://en.wikipedia.org/wiki/Oseltamivir
AdamantaneAdamantane
A nitrogen-substituted drug amantadine can be prepared by reacting adamantane with bromine or nitric acid to give the bromide ... The first adamantane derivative used as a drug was amantadine - first (1967) as an antiviral drug against various strains of ... Moiseev, I. K.; Doroshenko, R. I.; Ivanova, V. I. (1976). "Synthesis of amantadine via the nitrate of 1-adamantanol". ... Adapalene Adapromine Amantadine Bromantane Memantine Rimantadine Saxagliptin Tromantadine Vildagliptin Adamantane was recently ...
https://en.wikipedia.org/wiki/Adamantane
Maria ZambonMaria Zambon
Her thesis on 1 -aminoadamantane (also named amantadine) can be downloaded by using a link associated to the thesis' title in ... "Specific structural alteration of the influenza haemagglutinin by amantadine". The EMBO journal. Retrieved 14 June 2021. " ... "the mechanism of action of amantadine ... led directly to the identification of a novel class of viral proteins, viral ion ...
https://en.wikipedia.org/wiki/Maria_Zambon
Attention deficit hyperactivity disorderAttention deficit hyperactivity disorder
Amantadine was shown to induce similar improvements in children treated methylphenidate, with less frequent side effects. A ... Morrow K, Choi S, Young K, Haidar M, Boduch C, Bourgeois JA (September 2021). "Amantadine for the treatment of childhood and ... Mohammadi MR, Kazemi MR, Zia E, Rezazadeh SA, Tabrizi M, Akhondzadeh S (November 2010). "Amantadine versus methylphenidate in ... There are a number of non-stimulant medications, such as Viloxazine, atomoxetine, bupropion, guanfacine, amantadine (effective ...
https://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorder
NMDA receptor antagonistNMDA receptor antagonist
Amantadine: used for treating Parkinson's disease, influenza, and Alzheimer's disease. Atomoxetine: a norepinephrine reuptake ... Amantadine." MedlinePlus website Accessed 29 May 2007 Ludolph AG, Udvardi PT, Schaz U, Henes C, Adolph O, Weigt HU, Fegert JM, ...
https://en.wikipedia.org/wiki/NMDA_receptor_antagonist
ViroporinViroporin
Amantadine, which was discovered in the 1960s and has been in clinical use against influenza A for some time, is an example of ... Alves Galvão MG, Rocha Crispino Santos MA, Alves da Cunha AJ (November 2014). "Amantadine and rimantadine for influenza A in ... Oxford JS, Galbraith A (1980). "Antiviral activity of amantadine: a review of laboratory and clinical data". Pharmacology & ...
https://en.wikipedia.org/wiki/Viroporin
M2 proton channelM2 proton channel
Cady SD, Schmidt-Rohr K, Wang J, Soto CS, Degrado WF, Hong M (February 2010). "Structure of the amantadine binding site of ... According to the low pH crystal structure a single molecule of amantadine binds in the middle of the pore, surrounded by ... However, the BM2 channel activity is higher than that of AM2, and the BM2 activity is completely insensitive to amantadine and ... However, a recent solid state NMR spectroscopy structure shows that the M2 channel has two binding sites for amantadine, one ...
https://en.wikipedia.org/wiki/M2_proton_channel
PundingPunding
Amantadine has also reported to be fairly effective, while memantine, an analog of amantadine with a more targeted ... Kashihara, Kenichi; Imamura, Takaki (1 January 2008). "Amantadine may reverse punding in Parkinson's disease-Observation in a ... pharmacological profile has not been evaluated but would presumably have similar efficacy to amantadine. Selective serotonin ...
https://en.wikipedia.org/wiki/Punding
Amantadine: MedlinePlus Drug InformationAmantadine: MedlinePlus Drug Information
Amantadine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Amantadine may cause harm to the fetus.. *you should know that amantadine may make you drowsy or cause blurred vision. Do not ... Before taking amantadine,. *tell your doctor and pharmacist if you are allergic to amantadine, any other medications, or any of ... If you are taking amantadine for Parkinsons disease, your doctor may start you on a low dose of amantadine and gradually ...
https://medlineplus.gov/druginfo/meds/a682064.html
Amantadine ER Curbs Levodopa-Induced Dyskinesia in PDAmantadine ER Curbs Levodopa-Induced Dyskinesia in PD
An investigational extended-release formulation of amantadine with a unique chronotherapeutic pharmacokinetic profile eases ... "Amantadine has been around for ages and we know it helps dyskinesia," Dr. Pahwa noted in a telephone interview with Medscape ... "However, this is not a comparative study with immediate-release amantadine so its not possible to say head-to-head how it ... The low overnight amantadine plasma concentration may reduce the insomnia, sleep disturbances, and vivid dreams associated with ...
https://www.medscape.com/viewarticle/806835
Browsing by Subject AmantadineBrowsing by Subject "Amantadine"
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Is amantadine normally prescribed for dementia?Is amantadine normally prescribed for dementia?
... amantadine, prescription - Answer: Amantadine can also be used to treat ADHD and tardive dyskinesia. It took... ... Side effects of Amantadine (detailed). Similar questions. Information about Amantadine as an adult ADHD medication?. Updated 13 ... Why was amantadine discontinued for flu?. Updated 27 May 2021 1 answer FAQ by Drugs.com ... Amantadine is also used to treat or prevent influenza A in adults and children. It may not be effective during every flu season ...
https://www.drugs.com/answers/amantadine-prescribed-dementia-3560014.html
Update: Influenza Activity -- United States -- and the Role of Rapid Virus Typing in Improving Amantadine UseUpdate: Influenza Activity -- United States -- and the Role of Rapid Virus Typing in Improving Amantadine Use
... amantadine could be discontinued if either the outbreak continued to spread to amantadine-treated individuals and/or the ... Amantadine is not effective against influenza type B viruses or other respiratory pathogens. Although amantadine seldom causes ... Update: Influenza Activity -- United States -- and the Role of Rapid Virus Typing in Improving Amantadine Use Between December ... An alternative strategy would be to administer amantadine for 3 days to high-risk patients of an institution when an outbreak ...
https://www.cdc.gov/mmwr/preview/mmwrhtml/00000673.htm
Etodolac vs. Amantadine Comparison | PetMeds®Etodolac vs. Amantadine Comparison | PetMeds®
Amantadine with a detailed product breakdown. Visit PetMeds to save on Pain Relief Medications ...
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amantadineamantadine
Filed Under: Information Tagged With: amantadine, H1N1, influenza, M2, pandemic, swine flu, viral, virology, virus ... Filed Under: Basic virology, Information Tagged With: amantadine, antibody, H1N1, influenza, nosocomial, oseltamivir, pandemic ... Filed Under: Information Tagged With: amantadine, H1N1, H3N2, influenza, oseltamivir, resistance, zanamivir ... Twenty days later the patient developed a second bout of laboratory confirmed influenza which was treated with amantadine. The ...
https://www.virology.ws/tag/amantadine/
Amantadine - Dysautonomia Discussion - Dysautonomia Information Network (DINET)
I just started amantadine last week. The pharmacy printed the wrong dosing instructions and I ODed by an order of magnitude (I ... I survived (although, Ive read that 1 gram of amantadine can be a lethal dose). However, I was having heart palpitations the ... If you look at the 2006 CDC article in detail... they explain some technical reasons for amantadine and rimantadine to be less ... As for current non-H1N1 strains, Im not sure of an authoritative source but for what its worth, the Amantadine wikipedia ...
https://www.dinet.org/forums/topic/13575-amantadine/
Amantrel 100 mg (Amantadine) - ArrowmedsAmantrel 100 mg (Amantadine) - Arrowmeds
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Order Amantadine HCl 100mg Dosage, 90 Capsules at $59.40.Order Amantadine HCl 100mg Dosage, 90 Capsules at $59.40.
Amantadine is an anti-viral medication used to treat respiratory track infections. ... Order Amantadine HCl 100 dosage. Order at International and save up to $43.20. ... How will Amantadine HCl work in my body? How should Amantadine HCl be taken? How to reduce the risk of Amantadine HCl drug ... What are the questions to ask your doctor before taking Amantadine HCl?. Is it possible for me to take Amantadine HCl with ...
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Do online pharmacies sell Amantadine? What does it look like? | PharmacyChecker.comDo online pharmacies sell Amantadine? What does it look like? | PharmacyChecker.com
As noted in the image below, some versions of Amantadine sold in the United States are manufactured in India. ... Amantadine is a prescription medication used to treat influenza as well as Parkinsons disease. It is often used to treat ... Do online pharmacies sell Amantadine? What does it look like? A: ... You can find Amantadine 100 mg for as low as $0.34/pill when ... Buy Amantadine from Verified Online Pharmacies. To compare prices for Amantadine among verified international online pharmacies ...
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Dyskinesias induced by subthalamotomy in Parkinsons disease are unresponsive to amantadine | Journal of Neurology,...Dyskinesias induced by subthalamotomy in Parkinson's disease are unresponsive to amantadine | Journal of Neurology,...
Amantadine was therefore discontinued. One month after surgery both patients were free of involuntary movements with an ... The patient treated with DBS developed severe dyskinesia a few days after discharge and began self medication with amantadine ... This suggested a possible lack of response to amantadine for treatment of dyskinesias induced by surgery of the STN. ... Conclusion: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the " ...
https://jnnp.bmj.com/content/77/2/172
Amantadine | Johns Hopkins ABX GuideAmantadine | Johns Hopkins ABX Guide
Amantadine answers are found in the Johns Hopkins ABX Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, ... Amantadine is a topic covered in the Johns Hopkins ABX Guide. To view the entire topic, please log in or purchase a ... "Amantadine." Johns Hopkins ABX Guide, The Johns Hopkins University, 2022. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/ ... view/Johns_Hopkins_ABX_Guide/540013/6/Amantadine. Dzintars K, Auwaerter PG. Amantadine. Johns Hopkins ABX Guide. The Johns ...
https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540013/6/Amantadine
Amantadine Successful in Reducing Dyskinesia: Clinical TakeawaysAmantadine Successful in Reducing Dyskinesia: Clinical Takeaways
... context of these results and what the clinical community should take away from the data from the EASE LID 2 trial of amantadine ... A recent announcement from Adamas Pharmaceuticals confirmed that its long-term, open-label EASE LID 2 trial of amantadine ( ... EASE LID 2: A 2-Year Open-Label Trial of Gocovri (Amantadine) Extended Release for Dyskinesia in Parkinsons Disease. J ... The data suggested that treatment with amantadine was safe, tolerable, and resulted in a durable reduction in the motor ...
https://www.neurologylive.com/view/extendedrelease-amantadine-successful-in-reducing-dyskinesia
Amantadine - SPS - Specialist Pharmacy Service - The first stop for professional medicines adviceAmantadine - SPS - Specialist Pharmacy Service - The first stop for professional medicines advice
The first stop for professional medicines advice
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Oseltamivir- and Amantadine-Resistant Influenza Virus A (H1N1)Oseltamivir- and Amantadine-Resistant Influenza Virus A (H1N1)
Amantadine Antiviral Agents Drug Resistance, Multiple, Viral Humans Influenza, Human Influenza A Virus, H1N1 Subtype ... Title : Oseltamivir- and Amantadine-Resistant Influenza Virus A (H1N1) Personal Author(s) : Cheng, Peter K.C.;To, Amanda P.C.; ...
https://stacks.cdc.gov/view/cdc/18075
Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive...
Bartlett, J. (2004). Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of ... Bartlett, J 2004, Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of ... Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive ... Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive ...
https://jhu.pure.elsevier.com/en/publications/effects-of-alpha-interferon-induction-plus-ribavirin-with-or-with
Health Information | Griffin Health - Derby, Connecticut | Health Library
Amantadine. Amantadine is an antiviral drug used to treat fatigue. Some problems are: *Nausea ...
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Amantadine Appetite Suppressant < The Copy...Amantadine Appetite Suppressant < The Copy...
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Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. - Oxford Neuroscience
In agreement, p7 ion channel activity was not affected by amantadine, demonstrating that amantadine is not an HCV-selective ... We found that across a spectrum of HCV isolates and genotypes, amantadine affected neither RNA replication nor the release or ... One attempt to increase success rates is triple combination therapy of interferon and ribavirin with amantadine, a drug assumed ... we determined the antiviral effects of amantadine and iminosugar derivatives; the second of which primarily target host cell ...
https://www.neuroscience.ox.ac.uk/publications/100157?4c59b46c-9eec-11ed-a592-061ab7f93640
Amantadine Speeds Recovery After Severe TBI
Amantadine has been used since the 1980s to address parkinsonian symptoms in patients with brain injury, a natural follow-on to ... The study will have to be replicated before amantadine could be viewed as a standard of care, he added, "but its certainly a ... "Whether treatment with amantadine, as compared with placebo, improves the long-term outcome or simply accelerates recovery en ... Compared with placebo, amantadine effectively accelerated the pace of recovery of cognitively mediated behaviors, such as ...
https://www.staging.medscape.com/viewarticle/759591
In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine HydrochloridesIn Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides
Amantadine and rimantadine are approved antivirals used against susceptible influenza A virus infections that have been shown to ... In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides. dc.creator. Arias Arias, Jorge ... In Vitro Inhibition of Zika Virus Replication with Amantadine and Rimantadine Hydrochlorides. es_ES. ... we report the in vitro effectiveness of both amantadine and rimantadine hydrochlorides against ZIKV replication, resulting in a ...
https://www.kerwa.ucr.ac.cr/handle/10669/86986?show=full
Amantadine in Absence EpilepsyAmantadine in Absence Epilepsy
Keywords: Amantadine, Minor Motor Seizures, Absence Seizures How to Cite: Millichap, J.G., 1992. Amantadine in Absence Epilepsy ... Amantadine in Absence Epilepsy. Author: J Gordon Millichap Northwestern University Feinberg School of Medicine, US X close ... COMMENT. Amantadine was initially used by Shields et al. in the treatment of 10 children with minor motor seizures refractory ... Shahar, EM and Brand, N (1992). Effect of add-on amantadine therapy for refractory absence epilepsy. J Pediatr Nov 1992121(5 Pt ...
https://www.pediatricneurologybriefs.com/articles/10.15844/pedneurbriefs-6-12-6/
Parkitidin 100mg - Amantadine HydrochlorideParkitidin 100mg - Amantadine Hydrochloride
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Amantadine - Other :: Discount Pharmacy
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Amantadine - Other :: Online Pharmacy
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Hydrochloride100mg2022Parkinson'sSymmetrelTabletsInfluenza A virAntiviral drugKeep AmantadineGeneric AmantadineRimantadinePrescription2020ProphylaxisAdamas PharmaceuticalsOSMOLEXGocovriDoseDyskinesiaRibavirinCapsulesIndiaTreatmentAmantrelInteractRespiratoryDerivativesMedicinesVirusesResistantMedicationOccurCautionProfileSearchAlcoholExtended-releaseReplicationDrugsSide effectsDosesMedicinePillSymptomsLaboratoryResearchersDoctorImmediate-release
Hydrochloride5
  • Editorial Note: The antiviral drug, amantadine hydrochloride, is highly effective in preventing illness caused by influenza type A viruses and has been recommended by the Immunization Practices Advisory Committee (ACIP) as an adjunct to vaccination in the control of influenza A infections (2). (cdc.gov)
  • GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Parkitidin 100mg - Amantadine Hydrochloride which is also known as Parkitidin 100mg and Manufactured by Sun Pharmaceutical Ind Ltd . It is available in strength of 100mg per ml. (gnhindia.com)
  • Parkitidin 100mg - Amantadine Hydrochloride is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials. (gnhindia.com)
  • Did the author experience constipation while taking amantadine hydrochloride ? (druginformer.com)
  • Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. (bvsalud.org)
100mg1
20222
Parkinson's8
  • Amantadine extended-release capsules (Gocovri) are used along with the combination of levodopa and carbidopa (Rytary, Sinemet) to treat ''off'' episodes (times of difficulty moving, walking, and speaking that may happen when other medications wear off) in people with Parkinson's disease. (medlineplus.gov)
  • If you are taking amantadine for Parkinson's disease, your doctor may start you on a low dose of amantadine and gradually increase your dose. (medlineplus.gov)
  • He presented the results from the Extended Release Amantadine Safety and Efficacy Study in Levodopa-Induced Dyskinesia (EASED) clinical trial June 18 at the Movement Disorder Society (MDS) 17th International Congress of Parkinson's Disease and Movement Disorders. (medscape.com)
  • Amantadine is used to treat Parkinson's disease and 'Parkinson-like' symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs. (drugs.com)
  • Amantadine HCl is used to prevent or treat respiratory tract infection namely flu (influenza A). This antiviral medication is also used to treat Parkinson's disease, as well as drug-induced extrapyramidal reactions caused by certain psychiatric drugs. (internationaldrugmart.com)
  • Amantadine is a prescription medication used to treat influenza as well as Parkinson's disease. (pharmacychecker.com)
  • EASE LID 2: A 2-Year Open-Label Trial of Gocovri (Amantadine) Extended Release for Dyskinesia in Parkinson's Disease. (neurologylive.com)
  • Amantadine has been used since the 1980s to address parkinsonian symptoms in patients with brain injury, a natural follow-on to its use in Parkinson's disease, Dr. Giacino said. (medscape.com)
Symmetrel2
  • Generic drug Amantadine HCl is considered just as safe and effective as its brand-name equivalents such as Symmetrel and Lysovir. (internationaldrugmart.com)
  • Did you know that buying the generic drug Amantadine HCl from IDM is much cheaper than buying the Symmetrel or Lysovir brand drug? (internationaldrugmart.com)
Tablets3
  • tell your doctor and pharmacist if you are allergic to amantadine, any other medications, or any of the ingredients in amantadine capsules, extended-release capsules, tablets, extended-release tablets, or liquid. (medlineplus.gov)
  • Amantadine is available as tablets, capsules, and oral solution. (drugs.com)
  • However, you can contact an individual PharmacyChecker-verified pharmacy to inquire about the availability of Amantadine, extended-release tablets or capsules. (pharmacychecker.com)
Influenza A vir1
  • The Matrix 2 (M2) inhibitors ( amantadine and rimantadine ) have been used for prophylaxis and treatment of influenza A virus infections , however, resistance to these drugs has been widely reported. (bvsalud.org)
Antiviral drug1
  • This statement discusses the presently available medical-control measures, immunoprophylaxis with vaccines, and prophylaxis or therapy with the antiviral drug, amantadine. (cdc.gov)
Keep Amantadine2
  • Keep Amantadine out of the reach of children and away from pets. (dxmeds.com)
  • Keep Amantadine out with the reach of youngsters and far from pets. (simplemedrx.top)
Generic Amantadine1
Rimantadine3
  • On the basis of available antiviral testing results, CDC is providing an interim recommendation that neither amantadine nor rimantadine be used for the treatment or prophylaxis of influenza A in the United States for the remainder of the 2005?06 influenza season. (dinet.org)
  • Amantadine and rimantadine are approved antivirals used against susceptible influenza A virus infections that have been shown to have antiviral activity against other viruses, such as dengue virus (DENV). (ucr.ac.cr)
  • Here, we report the in vitro effectiveness of both amantadine and rimantadine hydrochlorides against ZIKV replication, resulting in a dose-dependent reduction in viral titers of a ZIKV clinical isolate and two different ZIKV reference strains. (ucr.ac.cr)
Prescription6
  • He swabbed my nose and sent it to the lab, gave me a week's worth of Tamiflu, and since Hubby hadn't had his flu shot he wrote him a prescription for Amantadine - and told me to take home a flu shot. (dinet.org)
  • Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Amantadine HCl, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
  • But evidence amantadine without a prescription only dwelling on the patient persistently ulcerated and eye colour. (disasterlesskerala.org)
  • Doctors are unmarked, so also reminded of the abdomen, mid-way between solid organ in late syphilis, amantadine no prescription scalpels remain on the sole cause is used. (disasterlesskerala.org)
  • Furthermore, amantadine without dr prescription a cord traction, immobilization and appear as delay resuscitation of the previous contralateral hemithorax, kinking and verbal contingencies for those with electrical appliances near the child. (disasterlesskerala.org)
  • We've talked 3 times about putting me on Amantadine I'm finally getting a prescription now but I should have recieved it 15mo ago. (ucsfhealth.org)
20201
  • globenewswire.com/news-release/2020/02/11/1983417/0/en/Adamas-Announces-Publication-of-the-Two-Year-Phase-3-Open-Label-EASE-LID-2-Trial-of-GOCOVRI-for-Dyskinesia-in-Patients-with-Parkinson-s-Disease.html. (neurologylive.com)
Prophylaxis1
  • The ability to rapidly diagnose influenza A infections would provide greater confidence in the use of amantadine for early treatment and prophylaxis of such cases, particularly when both type A and B influenza viruses are circulating. (cdc.gov)
Adamas Pharmaceuticals3
  • SYDNEY, Australia - Treatment with a proprietary investigational extended-release version of amantadine (ADS-1502, Adamas Pharmaceuticals) led to a statistically significant improvement in the duration and severity of levodopa-induced dyskinesia (LID) in a phase 2/3 study. (medscape.com)
  • The vice president of Medical Affairs at Adamas Pharmaceuticals discussed the context of these results and what the clinical community should take away from the data from the EASE LID 2 trial of amantadine (Gocovri). (neurologylive.com)
  • A recent announcement from Adamas Pharmaceuticals confirmed that its long-term, open-label EASE LID 2 trial of amantadine (Gocovri) extended-release capsules was successful in the treatment of levodopa-induced dyskinesia in patients with Parkinson disease. (neurologylive.com)
OSMOLEX1
  • Amantadine comes as a capsule, extended-release capsule (Gocovri), tablet, extended-release tablet (Osmolex), and liquid to take by mouth. (medlineplus.gov)
Gocovri1
  • These effects were seen in individuals directly entering this open-label study from earlier controlled trials as well as in patients with suboptimal response to DBS and those switching from amantadine immediate release (IR) to GOCOVRI. (neurologylive.com)
Dose6
  • Because of its altered pharmacokinetic profile, ADS-5102 is being investigated in clinical studies at daily doses 1.3- to 2.1-fold greater than the 100-mg twice-daily dose typically used with immediate-release amantadine. (medscape.com)
  • I survived (although, I've read that 1 gram of amantadine can be a lethal dose). (dinet.org)
  • What if you miss a dose of Amantadine HCl? (internationaldrugmart.com)
  • If your physician has instructed or directed you to take Amantadine HCl medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. (internationaldrugmart.com)
  • If you miss a dose of Amantadine, take it as soon as possible. (dxmeds.com)
  • If you miss a dose of Amantadine, take it at the earliest opportunity. (simplemedrx.top)
Dyskinesia5
  • Amantadine has been around for ages and we know it helps dyskinesia," Dr. Pahwa noted in a telephone interview with Medscape Medical News . (medscape.com)
  • Amantadine can also be used to treat ADHD and tardive dyskinesia. (drugs.com)
  • Prior to surgery, levodopa induced dyskinesia had improved (⩽50%) under treatment with amantadine (400 mg/day, po) in all three patients. (bmj.com)
  • The patient treated with DBS developed severe dyskinesia a few days after discharge and began self medication with amantadine but showed no improvement. (bmj.com)
  • Patients were scored using the dyskinesia scale and started treatment with 400 mg amantadine (po) for 4 days within the first postoperative week with no effect on dyskinesia score or its phenomenology. (bmj.com)
Ribavirin2
  • Bartlett, J 2004, ' Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C: A randomized trial ', Infectious Diseases in Clinical Practice , vol. 12, no. 2. (elsevier.com)
  • One attempt to increase success rates is triple combination therapy of interferon and ribavirin with amantadine, a drug assumed to interfere with HCV p7 ion channel function. (ox.ac.uk)
Capsules1
  • Currently, 30 capsules of Amantadine 100 mg can cost you as much as $50 ($1.67 per pill) at your local U.S pharmacy-and that's with a coupon. (pharmacychecker.com)
India5
  • As noted in the image below, some versions of Amantadine sold in the United States are manufactured in India. (pharmacychecker.com)
  • Amantadine resistance markers among low pathogenic avian influenza H9N2 viruses isolated from poultry in India, during 2009-2017. (bvsalud.org)
  • Information about amantadine susceptibility of H9N2 viruses from India is scanty. (bvsalud.org)
  • Matrix genes of 48H9N2 viruses isolated from India during 2009-2017 were sequenced and M2 trans- membrane region sequences were screened for mutations which are known to confer resistance to amantadine namely, L26F, V27A, A30 T/V, S31N and G34E. (bvsalud.org)
  • In conclusion, the present study reports prevalence and gradual increase of amantadine resistance among AI H9N2 viruses in India , emphasizing the importance of the antiviral surveillance . (bvsalud.org)
Treatment15
  • Treatment with ADS-1502 did not lead to clinical worsening of PD by standard measures, and reported adverse events were consistent with PD and the known amantadine safety profile, the researchers say. (medscape.com)
  • Amantadine is a generally well-tolerated medication that is more commonly used for off-label treatment of several pediatric neurobehavioral conditions such as attention deficit hyperactivity disorder, autism spectrum disorders, obsessive compulsive disorder, depression, and others. (drugs.com)
  • This suggested a possible lack of response to amantadine for treatment of dyskinesias induced by surgery of the STN. (bmj.com)
  • The data suggested that treatment with amantadine was safe, tolerable, and resulted in a durable reduction in the motor complications. (neurologylive.com)
  • March 2, 2012 - Results of a randomized trial confirm that treatment with amantadine can accelerate functional recovery among patients in vegetative or minimally conscious states after a traumatic brain injury (TBI). (medscape.com)
  • The study will have to be replicated before amantadine could be viewed as a standard of care, he added, "but it's certainly a big step toward having a standard of care for treatment of this population. (medscape.com)
  • To date, no treatment has been shown to change the pace of recovery or improve functional outcome in these patients, although several therapies are used off label, they note, with amantadine being one of the most commonly prescribed. (medscape.com)
  • The researchers' hypothesis for this trial, then, was that 4 weeks of treatment with amantadine, given 4 to 16 weeks after injury in patients in vegetative and minimally conscious states after TBI, would improve functional recovery and that the improvement would be maintained 2 weeks after drug washout. (medscape.com)
  • During the 4-week treatment period, recovery was significantly faster in the amantadine group, measured by using the Disability Rating Scale (DRS), a global functional outcome measure. (medscape.com)
  • Amantadine in the treatment of refractory epilepsy in childhood: an open trial in 10 patients. (pediatricneurologybriefs.com)
  • If you are using Amantadine for the flu, take it for the full course of treatment. (dxmeds.com)
  • If you are taking Amantadine for the flu, be sure to use Amantadine for the full course of treatment. (dxmeds.com)
  • If you're using Amantadine to the flu, go for the full course of treatment. (simplemedrx.top)
  • With its failure, with a pronounced expansion and tortuosity of the esophagus, a combination of amantadine cardia with other diseases (esophageal diverticula, hiatal hernia, heart aneurysm, etc.), surgical treatment is indicated. (amantadinet.com)
  • Amantadine disrupts lysosomal gene expression: A hypothesis for COVID19 treatment. (cdc.gov)
Amantrel1
  • Below is an example of Amantadine, manufactured by CIPLA LTD., labeled as Amantrel. (pharmacychecker.com)
Interact5
  • Many other medications may also interact with amantadine, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
  • What other drugs could interact with Amantadine HCl? (internationaldrugmart.com)
  • It may be noted that drugs other than those listed above may also interact with Amantadine HCl. (internationaldrugmart.com)
  • Some medical conditions may interact with Amantadine. (dxmeds.com)
  • Ask your health care provider if Amantadine may interact with other medicines that you take. (dxmeds.com)
Respiratory2
  • Amantadine is not effective against influenza type B viruses or other respiratory pathogens. (cdc.gov)
  • however, particularly for older individuals, it is undesirable to administer amantadine over the several weeks required to prevent possible spread or reintroduction of influenza A viruses once the first evidence for an outbreak is detected, if the outbreak is actually due to influenza B or another respiratory pathogen. (cdc.gov)
Derivatives1
  • Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus. (ox.ac.uk)
Medicines3
Viruses5
  • Amantadine is an antiviral medicine that blocks the actions of viruses in your body. (drugs.com)
  • Nasopharyngeal specimens properly collected from residents and/or staff members within the first 1-3 days of illness before administration of amantadine can be tested using fluorescent microscopy and recently developed monclonal antibody reagents (3,4) to determine within 1 day whether or not influenza type A viruses are responsible for the outbreak. (cdc.gov)
  • In such a case, amantadine could be discontinued if either the outbreak continued to spread to amantadine-treated individuals and/or the laboratory diagnosis identified influenza B rather than influenza A viruses. (cdc.gov)
  • All the viruses isolated during the year 2009 were sensitive to amantadine . (bvsalud.org)
  • However, resistance started to appear since the year 2010 and all the viruses isolated from the year 2015 onwards showed presence of molecular markers conferring resistance to amantadine . (bvsalud.org)
Resistant1
  • It may not be effective during every flu season because certain strains of the virus may be resistant to amantadine. (drugs.com)
Medication1
  • Information about Amantadine as an adult ADHD medication? (drugs.com)
Occur1
Caution1
Profile1
  • ADS-5102, given once nightly, has a unique "chronotherapeutic" pharmacokinetic profile characterized by a slow increase in initial amantadine plasma concentrations, high plasma concentrations during the day when LID can be troublesome, and low plasma concentrations overnight, the company notes in a statement. (medscape.com)
Search1
  • To compare prices for Amantadine among verified international online pharmacies, enter the name in the 'Compare Drug Prices' box, click the search icon, then follow the prompts to a list of pharmacies that offer it. (pharmacychecker.com)
Alcohol1
  • Limit alcohol intake while you are taking Amantadine. (dxmeds.com)
Extended-release1
  • patients have not been able to tolerate high enough doses or even just immediate-release amantadine per se, so the hope is the long-acting extended-release amantadine would be better tolerated and we could use higher doses with it," he explained. (medscape.com)
Replication1
  • We found that across a spectrum of HCV isolates and genotypes, amantadine affected neither RNA replication nor the release or infectivity of HCV particles. (ox.ac.uk)
Drugs1
Side effects4
  • Although amantadine seldom causes serious side effects in healthy, younger adults, it is more likely to cause troublesome side effects in older persons. (cdc.gov)
  • What are the side effects of Amantadine HCl? (internationaldrugmart.com)
  • It is pertinent to note that side effects of Amantadine HCl cannot be anticipated. (internationaldrugmart.com)
  • If any side effects of Amantadine HCl develop or change in intensity, the doctor should be informed as soon as possible. (internationaldrugmart.com)
Doses1
  • However, this is not a comparative study with immediate-release amantadine so it's not possible to say head-to-head how it would do against immediate-release, but from the data we have it was efficacious and patients were able to tolerate higher doses relatively well. (medscape.com)
Medicine1
  • Refractory absence epilepsy in 4 children was treated with amantadine as an add-on drug at the Tel Aviv University Sackler School of Medicine, Israel. (pediatricneurologybriefs.com)
Pill1
  • You can find Amantadine 100 mg for as low as $0.34/pill when ordering a 90-day supply by comparing prices on PharmacyChecker.com. (pharmacychecker.com)
Symptoms1
  • Terlipressin may develop withdrawl symptoms is essential price of amantadine of empowered self-care is ventilated, muscle biopsy or faintness. (disasterlesskerala.org)
Laboratory1
  • Twenty days later the patient developed a second bout of laboratory confirmed influenza which was treated with amantadine. (virology.ws)
Researchers2
  • Compared with placebo, amantadine effectively accelerated the pace of recovery of cognitively mediated behaviors, such as recognition of objects or verbalization, activities that form the foundation for functional independence, the researchers report. (medscape.com)
  • The mechanism is unclear, but amantadine appears to act as an N-methyl-D-aspartate antagonist and indirect dopamine agonist, the researchers note. (medscape.com)
Doctor5
  • Do not stop taking amantadine without talking to your doctor. (medlineplus.gov)
  • Do concur with your doctor and follow his directions completely when you are taking Amantadine HCl. (internationaldrugmart.com)
  • What are the questions to ask your doctor before taking Amantadine HCl? (internationaldrugmart.com)
  • A strange smile appeared on the corner of his mouth, Wuming said to Margarete Buresh What did you want to say to the amantadine appetite suppressant great doctor just now, what will you do to you. (thecopyshoponline.com)
  • Use Amantadine as directed by your doctor. (dxmeds.com)
Immediate-release1
  • The low overnight amantadine plasma concentration may reduce the insomnia, sleep disturbances, and vivid dreams associated with immediate-release amantadine. (medscape.com)
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