Alveolar Bone Loss: Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.Alveolar Process: The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Tooth Cervix: The constricted part of the tooth at the junction of the crown and root or roots. It is often referred to as the cementoenamel junction (CEJ), the line at which the cementum covering the root of a tooth and the enamel of the tooth meet. (Jablonski, Dictionary of Dentistry, 1992, p530, p433)Bacteroidaceae Infections: Infections with bacteria of the family BACTEROIDACEAE.Maxillary DiseasesBone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Bone Resorption: Bone loss due to osteoclastic activity.Porphyromonas gingivalis: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.Periodontium: The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Periodontal Ligament: The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Radiography, Bitewing: Technique involving the passage of X-rays through oral structures to create a film record while a central tab or wing of dental X-ray film is being held between upper and lower teeth.Photography, Dental: Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Tooth Socket: A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.Actinobacillus Infections: Infections with bacteria of the genus ACTINOBACILLUS.Aggregatibacter actinomycetemcomitans: A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.Periodontal Pocket: An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.Chronic Periodontitis: Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.Maxilla: One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.Macrophages, Alveolar: Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.Alveoloplasty: Conservative contouring of the alveolar process, in preparation for immediate or future denture construction. (Dorland, 28th ed)Gingiva: Oral tissue surrounding and attached to TEETH.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Ligation: Application of a ligature to tie a vessel or strangulate a part.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Tooth Movement: Orthodontic techniques used to correct the malposition of a single tooth.Osteonectin: Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Tooth Eruption: The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)Molar: The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Dental Cementum: The bonelike rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal, also assisting in tooth support by serving as attachment structures for the periodontal ligament. (Jablonski, Dictionary of Dentistry, 1992)Bone Diseases, MetabolicBone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Alveolar Bone Grafting: Surgical procedure to add bone to the ALVEOLAR RIDGE in children born with a CLEFT LIP and a CLEFT PALATE.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Bone Diseases: Diseases of BONES.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Tooth: One of a set of bone-like structures in the mouth used for biting and chewing.Tooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Radiography, Dental: Radiographic techniques used in dentistry.Tooth Root: The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)Periodontal Attachment Loss: Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.Mandibular DiseasesTooth Mobility: Horizontal and, to a lesser degree, axial movement of a tooth in response to normal forces, as in occlusion. It refers also to the movability of a tooth resulting from loss of all or a portion of its attachment and supportive apparatus, as seen in periodontitis, occlusal trauma, and periodontosis. (From Jablonski, Dictionary of Dentistry, 1992, p507 & Boucher's Clinical Dental Terminology, 4th ed, p313)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Dental Implants: Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.Pulmonary Alveolar Proteinosis: A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.

Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite: a light and electron microscopic observation using immunohistochemistry for PGP 9.5. (1/419)

Ruffini nerve endings (mechanoreceptors) in the periodontal ligament (PDL) of mouse incisors were examined to elucidate whether experimentally-induced crossbites cause any changes or abnormalities in their morphology and distribution. Anterior guiding planes were attached to the mandibular incisors of 3-week-old C3H/HeSlc mice. At 3 days and 1, 2, 4, 6, and 8 weeks post-attachment of the appliance, the mice were sacrificed by perfusion fixation. Frozen sagittal cryostat sections of the decalcified maxillary incisors were processed for immunohistochemistry of protein gene product 9.5, followed by histochemical determination of tartrate-resistant acid phosphatase activity to reveal sites of alveolar bone resorption. Despite the absence of bone resorption within the lingual PDL of control mice, distinct resorption sites were seen in the respective regions of the experimental animals. Unlike the controls, many Ruffini endings showing vague and swollen contours, with unusually long and pedunculated micro-projections were observed in the affected lingual PDL of the incisors in the experimental animals with short-term anterior crossbite induction. Club-shaped nerve terminations with few, if any, micro-projections were observed in the lingual PDL of experimental animals with long-term induction, as well as in aged control mouse incisors. Differences in the distribution of Ruffini endings were also observed. These results indicate that changing the direction of the force applied to the PDL results in rapid and prolonged changes in the morphology of Ruffini-like mechanoreceptors.  (+info)

Histological and histochemical quantification of root resorption incident to the application of intrusive force to rat molars. (2/419)

This study was conducted to investigate the nature of root resorption resulting from intrusive forces applied to the rat lower molars, by means of histological and histochemical techniques with tartrate resistant acid phosphatase (TRAP). Thirty-eight 13-week-old Wistar strain male rats were used. Intrusive force was created by a fixed appliance which was adjusted to exert an initial force of 50 g for the duration of 1, 2, and 3 weeks. The degree of root resorption and distribution of TRAP positive cells were evaluated. On the root surface, the TRAP positive scores were low in the apical regions. Significant differences in the scores were found in the inter-radicular region of the roots between the experimental and control groups for the 2- and 3-week groups. More active resorption of bone occurred during the experimental period, as denoted by greater TRAP positive scores on the bone than on the root surface. Root resorption scores in the apical root region were larger in the 2- and 3-week groups than in the 1-week group. Significant differences in the root resorption scores were also found between the 1- and 3-week groups in the inter-radicular region, indicating that intrusive force application of a longer duration may lead to a higher frequency of root resorption. It is shown that, irrespective of the level of TRAP positive cells and root resorption scores, the degree of root resorption activity is higher in the apical root region than in the inter-radicular area. These results indicate that cellular cementum may be resorbed more easily because of its richer organic components and low mineralized structure.  (+info)

Host modulation as a therapeutic strategy in the treatment of periodontal disease. (3/419)

Specific microorganisms initiate the immunoinflammatory processes that destroy tissue in periodontitis. Recent work has demonstrated, in addition to bacterial control, that modulation of the host immunoinflammatory response is also capable of controlling periodontitis. Matrix metalloproteinases (MMPs) destroy collagen and other matrix components, and the osteoclastic bone remodeling determines the periodontal bone response to a bacterial challenge. Other components of the biology, including cytokines and prostanoids, regulate MMPs and bone remodeling and are also involved in regulating the production of defensive elements, such as antibody. Agents directed at blocking MMPs or osteoclastic activity are effective in reducing periodontitis. Agents that inhibit prostaglandin E2 and selective blockage of specific cytokines have also been effective. Improved knowledge of bacterium-host interactions and of the processes leading to tissue destruction will help to identify targets for host modulation to reduce periodontitis in selected situations.  (+info)

CD4(+) T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. (4/419)

In this study, we used a mouse model to examine the role of the adaptive immune response in alveolar bone loss induced by oral infection with the human gram-negative anaerobic bacterium Porphyromonas gingivalis. Severe combined immunodeficient mice, which lack B and T lymphocytes, exhibited considerably less bone loss than did immunocompetent mice after oral infection, suggesting that lymphocytes contribute to this process. Bone loss after oral infection was decreased in mice deficient in major histocompatibility complex (MHC) class II-responsive CD4(+) T cells, but no change in bone loss was observed in mice deficient in MHC class I-responsive CD8(+) T cells or NK1(+) T cells. Mice lacking the cytokine gamma interferon or interleukin-6 also demonstrated decreased bone loss. These results suggest that the adaptive immune response, and in particular CD4(+) T cells and the proinflammatory cytokines that they secrete, are important effectors of bone loss consequent to P. gingivalis oral infection. The studies also reinforce the utility of the mouse oral infection model in dissecting the pathobiology of periodontal disease.  (+info)

C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction. (5/419)

C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.  (+info)

Host responses to recombinant hemagglutinin B of Porphyromonas gingivalis in an experimental rat model. (6/419)

Porphyromonas gingivalis, a gram-negative, black-pigmented anaerobe, is among the microorganisms implicated in the etiology of adult periodontal disease. This bacterium possesses a number of factors, including hemagglutinins, of potential importance in virulence. Several hemagglutinin genes have been identified, cloned, and expressed in Escherichia coli. The purpose of this study was to characterize host responses to purified recombinant hemagglutinin B (rHag B), using the conventional Fischer rat as the experimental animal model. The effectiveness of immunization with rHag B on protection against experimental periodontal bone loss following infection with P. gingivalis was also evaluated. Groups of rats were immunized by the subcutaneous route with rHag B in complete Freund's adjuvant, immunized with rHag B and orally infected with P. gingivalis, nonimmunized and noninfected, or orally infected with P. gingivalis only. Serum and saliva samples were collected throughout the experiment and evaluated for serum immunoglobulin G (IgG) and IgM and salivary IgA antibody activity by enzyme-linked immunosorbent assay. No salivary IgA anti-Hag B activity was detected in the various groups of rats. A slight serum IgM response similar to that seen in preimmune samples was observed. Serum IgG antibody activity to Hag B was detected only in samples from rats immunized with rHag B. This response was primarily of the IgG1 and IgG2a subclasses, followed by IgG2b and low levels of IgG2c. Supernatants from rHag B-stimulated splenic lymphoid cell cultures from immunized rats contained high levels of gamma interferon, followed by interleukin-2 (IL-2), IL-10, and then IL-4. These results are consistent with the induction of T helper type 1 (Th1)- and Th2-like responses. Western blot analysis of sera derived from rHag B-immunized rats reacted with trichloroacetic acid (TCA) precipitates of P. gingivalis 33277, 381, A7A1-28, and W50, revealing a 50-kDa band reflective of Hag B. However, sera derived from rats immunized with P. gingivalis whole cells or from rats infected with P. gingivalis only did not react with rHag B but did react with TCA precipitates of P. gingivalis strains. Finally, radiographic measurements of periodontal bone loss indicated that rats immunized with rHag B had less bone loss than those infected with P. gingivalis only. These results demonstrate the effectiveness of purified rHag B in inducing a protective immune response and support the potential usefulness of this component of P. gingivalis in the development of a vaccine against adult periodontitis.  (+info)

Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. (7/419)

The CD28 costimulation at TCR signaling plays a pivotal role in the regulation of the T cell response. To elucidate the role of T cells in periodontal disease, a system of cell transfer with TCR/CD28-dependent Th1 or Th2 clones was developed in rats. Gingival injection of specific Ag, Actinobacillus actinomycetemcomitans 29-kDa outer membrane protein, and LPS could induce local bone resorption 10 days after the transfer of Ag-specific Th1 clone cells, but not after transfer of Th2 clone cells. Interestingly, the presence of LPS was required not only for the induction of bone resorption but also for Ag-specific IgG2a production. LPS injection elicited the induction of expression of both B7-1 and B7-2 expression on gingival macrophages, which otherwise expressed only MHC class II when animals were injected with Ag alone. The expression of B7 molecules was observed for up to 3 days, which corresponded to the duration of retention of T clone cells in gingival tissues. Either local or systemic administration of CTLA4Ig, a functional antagonist of CD28 binding to B7, could abrogate the bone resorption induced by Th1 clone cells combined with gingival challenge with both Ag and LPS. These results suggest that local Ag-specific activation of Th1-type T cells by B7 costimulation appeared to trigger inflammatory bone resorption, whereas inhibition of B7 expression by CTLA4Ig might be a therapeutic approach for intervention with inflammatory bone resorption.  (+info)

Long-term follow-up of maxillary incisors with severe apical root resorption. (8/419)

The purpose of the study was to analyse the mobility of teeth with severe orthodontically induced root resorption, at follow-up several years after active treatment, and to evaluate mobility in relation to root length and alveolar bone support. Seventy-three maxillary incisors were examined in 20 patients, 10-15 years after active treatment in 13 patients (age 24-32 years) and 5-10 years after active treatment in seven patients (age 20-25 years). All had worn fixed or removable retainers; seven still had bonded twistflex retainers. Total root length and intra-alveolar root length were measured on intra-oral radiographs. Tooth mobility was assessed clinically according to Miller's Index (0-4) and the Periotest method. Crestal alveolar bone level, periodontal pocket depth, gingival, and plaque indices, occlusal contacts during occlusion and function, and dental wear were recorded. There was a significant correlation (P < 0.05) between tooth mobility, and total root length and intra-alveolar root length. No correlation was found between tooth mobility and retention with twistflex retainers. None of the variables for assessment of periodontal status, occlusion and function were related to total root length or tooth mobility. It is concluded that there is a risk of tooth mobility in a maxillary incisor that undergoes severe root resorption during orthodontic treatment, if the remaining total root length is < or = 9 mm. The risk is less if the remaining root length is > 9 mm. Follow-up of teeth with severe orthodontically induced root resorption is indicated.  (+info)

TY - JOUR. T1 - Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats. AU - Kador, Peter F.. AU - Hamada, Tomofumi. AU - Reinhardt, Richard A.. AU - Blessing, Karen. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Periodontitis is a lesser known but frequent complication of diabetes mellitus and is the major cause of tooth loss in patients with diabetes. Dental therapy for this complication is primarily focused on the control of oral infections. No current therapy directly addresses the potential effects of diabetes itself on this complication. In studies conducted in young normal control and streptozotocin diabetic rats (100 g) treated with and without the aldose reductase inhibitor (ARI) imirestat, experimental periodontitis was induced in one side of the mouth by 3 injections of lipopolysaccharide (LPS) from Escherichia coli 055:B5 9 into the palatal gingiva between the first and second maxillary molars at 48-hour intervals. The other control side was ...
BACKGROUND AND OBJECTIVES: Strontium ranelate is a medication indicated for the treatment of osteoporosis that presents concomitant anti-resorptive and osteoanabolic dual biological activity. However, the effects of strontium ranelate on alveolar bone have been poorly explored. Furthermore, to date, there are no data on the effects of this medication on alveolar bone loss (BL) during conditions of estrogen deficiency. Therefore, the aim of this study was to evaluate the effects of strontium ranelate on ligature-induced periodontitis in estrogen-deficient and estrogen-sufficient rats. METHODS: Ninety-six rats were assigned to one of the following groups: sham-surgery + water (estrogen-sufficient; n = 24); ovariectomy + water (estrogen-deficient; n = 24), sham-surgery + strontium ranelate (ranelate/estrogen-sufficient; n = 24) and; ovariectomy + strontium ranelate (ranelate/estrogen-deficient; n = 24). The rats received strontium ranelate or water from the 14th day after ovariectomy until the end ...
Objective: In this study we have assessed the renal and cardiac consequences of ligature-induced periodontitis in both normotensive and nitric oxide (NO)-deficient (L-NAME-treated) hypertensive rats.Materials and methods: Oral L-NAME (or water) treatment was started two weeks prior to induction of periodontitis. Rats were sacrificed 3, 7 or 14 days after ligature placement, and alveolar bone loss was evaluated radiographically. Thiobarbituric reactive species (TBARS; a lipid peroxidation index), protein nitrotyrosine (NT; a marker of protein nitration) and myeloperoxidase activity (MPO; a neutrophil marker) were determined in the heart and kidney.Results: In NO-deficient hypertensive rats, periodontitis-induced alveolar bone loss was significantly diminished. In addition, periodontitis-induced cardiac NT elevation was completely prevented by L-NAME treatment. on the other hand L-NAME treatment enhanced MPO production in both heart and kidneys of rats with periodontitis. No changes due to ...
Journal of Shahid Sadoughi University of Medical Sciences ماهنامه علمی پژوهشی دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد
This might be one of several explanations as to why elevated bacteria and the combination of specific pathogens in periodontal pockets can be linked to a history of ACS," said Stefan Renvert, DDS, PhD and Department of Health Sciences, Kristianstad University. "We also found that the amount of periodontal bacteria results in an inflammatory response that elevates the white blood cell counts and high sensitivity C-reactive protein levels, which has also been linked in past studies to heart disease.". It was also found that the extent of alveolar bone loss was significantly greater among subjects with ACS. Seventy-seven percent of the participants in the ACS group and 42 percent in the control group demonstrated evidence of periodontitis. The extent of bone loss was more severe in the ACS group than in the non-ACS group.. Another reason people diagnosed with ACS may have higher oral bacteria could be due to their infectious susceptibility and lack of an adequate host inflammatory response, which ...
Teens involvement in numerous sports and recreational activities will damage maxillofacial features. Cases like a broken tooth increase the feasibilities of root infections & provide an obnoxious smile. A lot of them also get obstacles in eating & speaking during overbite. The lifestyle choices of teens also influence the challenges of cavities, impacted wisdom teeth, crowding issues, and gum diseases. The hectic schedule of adults demands a restricted brushing routine, not sufficient to remove plaques. Decays develop as a result of this and eventually result in severe conditions like oral cancer or gum infections. They also experience excessive edentulism imposed by smoking & lack of oral hygiene. Such voids spaces left by missing teeth leads to excessive alveolar bone loss in addition to deterioration in facial aesthetics ...
Curcumin is a yellowish polyphenol extracted from the rizome of a herbaceous tropical plant. It has multiple biological activities described, including anti-inflammatory, antioxidant, antiangiogenic, immunomodulatory, cytotoxic, antimicrobial and pro- and antiapoptotic activities. Its therapeutic application is actively evaluated in preclinical models and clinical studies of various diseases. In vivo use of curcumin is limited by its pharmacodynamic propereties, such as poor solubility in aqueous vehicles, low absorption rate in the gastrointestinal tract and short half-life in the peripheral circulation. The aim of this study was to evaluate the dose-response effect of a synthetic compound that is structurally to natural curcumin (CMC2.24) in a model of experimental periodontal disease that mimics the host-microbial interaction and the resultant inflammation and bone resorption that are hallmarks of this conditions in humans. Periodontal disease was induced in mice by injection of 30 ug LPS of ...
OBJECTIVE: The purpose of this study was to evaluate whether local administration of TIL could influence the expression of the inflammatory mediators IL-1β, TNF-α, MMP-8 and COX-2 in rats with experimental periodontitis (EP). METHODS: Twenty-four adult male rats (Rattus norvegicus, albinus, Wistar) were assigned to groups C, EP, EP-TIL (CControl group, EP-Periodontitis groups). On EP groups, a ligature was placed around maxillary 2nd molars on day 1. On group EP-TIL, 20 μL of TIL solution (1 mg/kg body weight) was injected into the subperiosteal palatal area adjacent to the maxillary 2nd molar every other day until euthanasia (day 11 ...
(2005) Young et al. Tissue Engineering. Tooth loss accompanied by alveolar bone resorption presents a significant clinical problem. We have investigated the utility of a tissue-engineering approach to provide corrective therapies for too...
Particularly suited for treatment of smaller defects and periodontal bone defects. Can be cut to shape and size in dry or wet conditions. Does not stick to itself and to instruments. Can be easily repositioned, if needed. Exceptional adaptability to surface contour after rehydration.. ...
Vitamins and minerals essential for improving the nutritional environment of periodontal bone and tissue.These statements have not been evaluated by the Food and Drug Administration (FDA). These products are not meant to diagnose, treat or cure any disease or medical condition. Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition.
PROTOCOL OUTLINE: This is a randomized, double-blind, placebo controlled study. Patients are randomly assigned to receive placebo or conjugated estrogens and, if no prior hysterectomy, medroxyprogesterone. Patients also receive calcium supplementation therapy daily for 3 years.. Participants in the placebo group may be removed from study if bone loss exceeds 5% per year.. A study duration of 3 years is anticipated. ...
Purpose: The aim of this study was to compare vertical and horizontal mandibular alveolar bone resorption by measuring bone morphological variation in Kennedy Class II removable partial denture (RPD) wearers and non-wearers using cone-beam computed tomography (CBCT).. Materials and Methods: In total, 124 sites in the CBCT scans of 62 (29 RPD non-wearers, 33 RPD wearers) Kennedy Class II patients were analyzed retrospectively. Three-dimensional representations of the mandible with superimposed cross-sectional slices were developed with the CBCT scans to evaluate the mandibular alveolar height and width by measuring distances between the mandibular canal, mylohyoid ridge, alveolar crest, and lower border of the mandible in four regions (eight sites) of Kennedy Class II non-wearers and wearers of RPDs.. Results: Mandibular alveolar bone height and width were significantly lower in edentulous sites when compared with dentate sites in both Kennedy Class II non-wearers and wearers of RPDs (p , 0.05). ...
Oral bone loss is a major concern amongst a large population suffering from estrogen deficiency, osteoporosis and periodontal diseases. The clinical implication of oral bone loss is premature tooth loss. Mechanical loading has proven to be vital in maintaining the quantity and quality of the bone, particularly in impacted bone. Studies have shown that long bones (post-cranial) and alveolar bone (cranial) are both sensitive to mechanical environment through static and dynamic loading. It also has been suggested that whole body vibrations (WBV) at low-magnitude and high frequency are a non-invasive and non-pharmacological method to prevent bone loss, particularly in the long bones. However, not much has been said about the application of these low-magnitude high frequency loads on the alveolar bone. In this pilot study, it is determined if low magnitude of 0.3 g (where g = 9.8ms,super,-2,/super,) and high frequency of 50 Hz, localized vibrations can be transmitted to the alveolar bone and also ...
This study was planned to determine whether a short period dexamethasone treatment induce alveolar bone loss or not, therefore, twenty six male albino rabbits were divided into three groups as follow: Test groups I (10 rabbits) received 1.56 mg/kg dexamethasone intraperitoneal injection daily for two weeks, test group II (10 rabbits) received 3.12 mg/kg dexamethasone intraperitoneal injection daily, and the control group (6 rabbits) received saline solution for same period. The animals were sacrificed and histological sections were prepared from the alveolar bone of molar areas of mandible, as well as morphometric analysis of osteoclasts number was performed. The results showed a significant increase in the number of osteoclasts, which indicates that bone loss, is quite inevitable secondary to dexamethasone treatment even in a short period of treatment for two weeks.
In an article titled Periodontal Assessments of Postmenopausal Women Receiving Risedronate, a graduate of the Case Western Reserve University School of Dental Medicine, reports that drugs that are used to combat
Researchers at the University at Buffalo have been able to identify two key components in saliva that could be used to predict the amount of oral bone loss in future.
The treatment of intrabony defects is a real challenge in molar teeth as it is chronic, slowly progressing disease which needs timely intervention. Periodontal inflammation associated with intrabony defect is not a separate entity as it secondarily affects the pulp causing retrograde pulpitis. However, treatment of these lesions will be complicated due to extensive bone loss. The tooth was endodontically treated followed by periodontal surgery to eliminate the deep periodontal pocket and promote bone fill in osseous defect. PepGen P-15 composited with platelet rich plasma was utilized for enhancing bone formation. The combination of these graft materials provides synergistic effect on bone regeneration.
Researchers compared the effect of a daily atorvastatin 80 mg dose versus a 10 mg dose in a randomized, multi-center trial with 71 subjects with established atherosclerosis or risk factors for atherosclerosis. Patients were evaluated using F-Flurodexoyglucose positron emission tomography (FDG-PET) imaging. After 12 weeks, there was a significant reduction in periodontal inflammation in subjects randomized to the 80 mg dose (p=0.04). Reductions in periodontal inflammation were greatest in individuals with higher levels of periodontal inflammation at baseline (p=0.01) and in those with higher periodontal bone loss at baseline (p=0.03). The reductions in periodontal inflammation correlated with reductions in carotid inflammation (p,0.001). "The impact of high-dose statin was greatest in individuals with evidence of active periodontitis and was evident after a four-week treatment period," said lead author Sharath Subramanian, MD, Massachusetts General Hospital and Harvard Medical School, Boston. "We ...
Differing theories of the nature of periodontal disease progression have been proposed, but there is no convincing statistical evidence with which to choose between them. Three models for disease progression are developed, and their covariance structures are derived and shown to be hierarchical. The estimation of the covariance structures of...
Purpose: The purpose of this scholarly study is to evalute the anti-inflammatory ramifications of morus migra on experimentally-induced periodontitis in rats. Outcomes: Morus nigra treatment reduced tissues MMP-8 and MMP-13 amounts and there have been significant differences regarding tissue degrees of MMP-8 and MMP-13 between groupings PER and MN+PER (p=0.035, p=0.041). There have been no significant distinctions among all of the groupings serum degrees of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was higher in the PER group compared to C and MN organizations (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Summary: The present study shows that systemic administration of Morus nigra significantly inhibited the regional alveolar bone AC220 manufacturer resorption and contributes to periodontal ...
Results: No significant differences were found between both groups in survival, complications, or marginal bone resorption. One axially placed implant was lost at 58 months in group 1, rendering a cumulative survival estimate at 5 years of 96.7% and 98.3% in group 1 and the total sample, respectively (P = .317). Mechanical complications occurred in 16 patients (26.7%; n = 8 patients in each group; [P > .999]), consisting of fractures in the provisional prosthesis (n = 8 patients), chipped ceramics of the definitive prosthesis (n = 2 patients), loosening of prosthetic components (n = 5 patients), and fracture of an attachment screw (n = 1 patient). Biologic complications occurred in 5 patients (8.3%; group 1 = 4 patients; group 2 = 1 patient; [P = .161]), consisting of peri-implant pathology. The mean ± SD marginal bone loss was 2.02 ± 0.36 mm and 1.90 ± 0.69 mm for groups 1 and 2, respectively (P = .235). In group 1, the mean ± SD marginal bone loss was 1.92 ± 0.48 mm and 2.11 ± 0.44 mm ...
Parathyroid hormone is an endogenous hormone with potent anabolic and catabolic actions in bone. It has recently been approved for the treatment of osteoporosis and is marketed as FORTEO by Eli Lilly and Company. Numerous studies in humans have validated its use to increase bone mineral density and prevent fractures. Interest has also surfaced in its potential application in the treatment of non-osteoporotic fractures and several animal studies have supported this local application. Little is known regarding its use in treating conditions of the oral cavity, but animal studies suggest that bones of the oral cavity are responsive to the anabolic actions of PTH. Furthermore, a recent study indicated that in a canine model, PTH was effective at reversing periodontal bone loss. Studies from our laboratory indicate that patients with hyperparathyroidism (HPT) do not have an increase in periodontal disease as measured by attachment levels. In fact, in our patient population there was an increase in ...
The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. Our method uses biological knowledge expressed by Gene Ontology and generates a rule model associating this knowledge with minimal characteristic features of temporal gene expression profiles. The relatively low attack rate and also relative risk requires large sample sizes for free cialis generic testing hypotheses. From genes to function: the next challenge to understanding multiple sclerosis.. Recommendations for early diagnosis and intervention in autism spectrum disorders: an Italian-Israeli consensus conference. The purpose of this article is to reexamine some of the principles of correction. 6-Shogaol was shown to damage microtubules and discount generic cialis induce mitotic arrest. There was a weak association between adduct levels and daily cigarette consumption above 10 cigarettes per day. The results indicate that the PFD could be a useful tool for ...
The Straumann® Bone Level Tapered (BLT) Implant offers all the clinically proven features of the Straumann® Bone Level Implant line plus the advantages of a tapered implant body. This leads to excellent primary stability in soft bone and fresh extraction sockets. The tapered form adequately compresses the underprepared osteotomy. It also lets you effectively master your patients limited anatomy, such as facial undercuts, converging root tips, a concave jaw structure or narrow atrophied ridges ...
Australian Wine Cluster Supplementary Information Case Study Help, Case Study Solution & Analysis & Obesity induces gingival oxidative pressure, thats associated with the development of alveolar bone resorption. The antioxidant influence of hydrogen-load
Current therapeutics such as bisphosphonates or anabolic agents do not always effectively prevent or treat osteoporosis and inflammatory bone loss in rheumatoid...
I am new to the forum and tomorrow I am going in for the beginning of having dental implants due to bone loss! I have been so confused as to why I have had bone loss. I had PE with all 3 of my children and HELLP with my second. My youngest is 8 years old and I am approaching 49. My Mother had PE her first pregnancy and had dental bone loss issues. Back in the 1970s they told her here bone loss was due to her pregnancies. I am glad I decided to search for this. It gives me something to think about ...
31 years-old male patient was loss of anterior teeth for 1 year. . We have treated this case using Geistlich Bio-Oss® and Geistlich Bio-Gide® guide bone regeneration. After 6 months, the post-examination showed that that site had well-developed alveolar bone. After 1 year, permanent restoration was performed.. ...
... Definition Periodontal fiber is attached to the dentin of the root of the tooth by cementum and to the bone of the jaws by alveolar bone.
Bone loss is a problem that not only plagues the elderly, but the younger generation as well. This condition does not form overnight. Nobody can say that with just a ...
Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular accident, and independent associations with periodontal disease (PD) are reported. PD is caused by polymicrobial infections and aggressive immune responses. Genomic DNA of Porphyromonas gingivalis, the best-studied bacterial pathogen associated with severe PD, is detected within atherosclerotic plaque. We examined causal relationships between chronic P. gingivalis oral infection, PD, and atherosclerosis in hyperlipidemic ApoEnull mice. ApoEnull mice (n = 24) were orally infected with P. gingivalis for 12 and 24 weeks. PD was assessed by standard clinical measurements while the aorta was examined for atherosclerotic lesions and inflammatory markers by array. Systemic inflammatory markers serum amyloid A, nitric oxide, and oxidized low-density lipoprotein were analyzed. P. gingivalis infection elicited specific antibodies and alveolar bone loss. Fluorescent in situ hybridization detected viable P. gingivalis
Clinicians very often have seen marginal bone loss around dental implants at the crest level early on after implant placement and uncovering. Early clinical publications had suggested that this bone loss occurred during the first year of loading. Thus, numerous attempts have been made to minimize or eliminate such bone loss. However, the timing and reason for this bone loss are not always apparent. The objective of this study was to review the evidence regarding marginal bone loss around dental implants from the standpoint of biologic consequences to help understand marginal bone changes around dental implants. One hypothesis for the bone loss around these implants was related to the presence of bacteria in the interfaces between the implant and abutment connections. The literature was reviewed regarding the three major types of implant-abutment crestal connections, including butt-joint, platform-switched, and no interface (tissue-level or one-body). This review article revealed that 1.5 to 2.0 ...
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A range of regenerative treatments have been used for the treatment of periodontal infrabony defects. Guided tissue regeneration (GTR) and enamel matrix derivatives (EMD) are two popular treatment and they have both been used in combination with other treatment. This network meta-analysis was conducted to assess the potential effects of the various combinations. Unlike a [read the full story…]. ...
The suitability of a mouse model for host response in the induction of alveolar bone loss by Porphyromonas gingivalis was explored. The mouths of immunocompetent and severe combined immunodeficient (SCID) mice were infected with P. gingivalis ATCC 53977. P. gingivalis was not isolated from the mouths of these mice before infection, but was present at least 42 days after infection. P. gingivalis-specific IgG was present in sera from the infected, immunocompetent mice at the end of these experiments (42 days). Specific IgG was not present in sham-infected or uninfected immunocompetent mice, nor in any immunodeficient mice. Specific IgM was not present in any sera at 42 days. Infected, immunocompetent mice of two strains showed significant bone loss in comparison to sham-infected or uninfected immunocompetent mice (p | 0.05). Infected SCID mice, which are genetically lacking both B and T lymphocytes, also showed significant bone loss compared with sham-infected or uninfected SCID mice (p | 0.05
PURPOSE: The purpose of this animal study was to confirm that laser Doppler flowmetry (LDF) is a reproducible method for the assessment of maxillary and mandibular alveolar bone vascularity and that there is less vascularity in irradiated mandibular and maxillary bone compared to nonirradiated bone. MATERIALS AND METHODS: All maxillary and mandibular premolars and molars of 6 Gottingen minipigs were extracted. After a 3-month healing period, 3 minipigs received irradiation at a total dose of 24 Gy. Three months after irradiation, 5 holes were drilled in the residual alveolar ridge of each edentulous site in each minipig. Local microvascular blood flow around all 120 holes was recorded by LDF prior to implant placement. In 1 irradiated and 1 nonirradiated minipig, an additional hole was drilled in a right maxillary site to enable repeated LDF recordings. RESULTS: The alveolar bone appeared less vascularized in irradiated than in nonirradiated minipigs. The effect of radiation appeared more ...
Non-healing bone fractures and periodontal bone loss constitute significant clinical problems with few approved medical options. Bone repair is enhanced by the presence of osteoblasts or osteoblastic precursor cells. Subcutaneous adipose tissue is a plentiful, accessible, and replenishable source of human stromal cells for transplantation. In Phase I of this SBIR, we tested the hypothesis that human adipose tissue-derived stromal cells are capable of osteoblast function. Substantial in vitro data indicates that these stromal cells differentiate into cells biochemically and morphologically similar to osteoblasts. The ability of these cells to form bone in vivo was examined as well. Phase II of this SBIR will extend these in vivo experiments. Specific Aim 1 examines the ability of human adipose tissue-derived stromal cells to form ectopic bone in hydroxyapatite ceramic cubes implanted subcutaneously in immunodeficient mice. Specific Aim 2 explores whether the introduction of a modified bone ...
If you have been in practice long enough, you will have run into something like this eventually. This is a 76 year old farmer who has fairly obviously been "grinding his teeth". In fact, you would be making a correct assumption. Note that the tooth wear is much worse anteriorly than it is in the posterior. As we will eventually see, this is diagnostic of abrasion from bruxism. But notice a few other less obvious things. You see no occlusal amalgam fillings in the posterior teeth. You see no plaque or redness around the gingiva. You see no active decay anywhere. Furthermore, the patient has no periodontal bone loss in spite of a serious bruxing habit. On the other hand, you do see a few buccal composite fillings along with severe buccal-cervical wear. We can conclude the following from these observations:. This patient has probably never used too much sugar. We conclude this by the lack of amalgam fillings in the intact molars and the occlusal of #4, the one "surviving" premolar.. The patient has ...
Our understanding about periodontal disease progression improved tremendously during 1960s, when animal and human experiments demonstrated the role of bacteria in the initiation of gingivitis and periodontitis 1, 2. These studies led to the proposal of the model of bacterial etiology of periodontal disease. Further investigations in this field led to the advancement of our knowledge of pathogenic bacteria causing disease progression. Specific Gram-negative, anaerobic, or microaerophilic bacteria were implicated in the causation of periodontitis 3-7. During late 1970s and early 1980s protective and destructive roles of the immunoinflammatory responses were described in health and disease 8-14.. Most of the models of periodontal disease progression in the late 1980s stated that specific bacteria initiated the disease process by activating host responses, which were protective and destructive. The actual destruction of connective tissue and bone resulted primarily from inflammatory chemical ...
A polylactide-polyglicolide(PLA-PGL) has been documented clinically to enhance bone regeneration in closed bone defects and to sustain periodontal healing in intrabony defects. So far, there are no controlled clinical studies to compare the effect of the PLA-PGL with the effect of other "biological agents" in treating deep intrabony defects. Aim of the study: to compare treatment of deep intrabony defects with PLA-PGL(Fisiograft®,Ghimas,Italy) to an enamel-matrix-protein-derivative(EMD; Emdogain®,Straumann AG,Waldenburg,Switzerland). Nineteen patients, displaying 26 intrabony defects, were randomly treated with PLA-PGL (test) or with EMD(control). Soft tissue measurements were made at baseline and 6 months after. No differences in the investigated parameters were observed at baseline between groups. Wilcoxon and Mann-Whitney tests were used for statistics. Alpha-error was set 0.05, the power-of-the-study 0.57. No adverse healing response was observed. Six months after, sites treated with ...
Non-contained intrabony defect treated using cerabone®, collprotect® membrane and Straumann® Emdogain® - Dr. T. Schwaar (2 ...
Evaluation of the Effect of Buccolingual and Apicocoronal Positions of Dental Implants on Stress and Strain in Alveolar Bone by Finite Element Analysis
Calcium aids in development of strong bones and teeth. It also helps your heart, nerves, and muscles. Calcium deficiency often doesnt show symptoms right away, but leads to serious health problems over time. If calcium consumption isnt enough, your body may use the calcium from your bones instead, leading to bone loss.. Experts also believe that calcium deficiencies may be related to low bone mass and weakening of bones due to osteoporosis.. Calcium deficiency leads to convulsions and abnormal heart rhythm which can be life-threatening. Postmenopausal women experience greater bone loss due to changing hormones experiencing troubles absorbing calcium.The best sources of calcium are dairy products such as milk, yogurt, cheese, calcium-set tofu, and small fish with bones. Vegetables such as kale and broccoli also have calcium, and many cereals and grains are calcium-fortified.. ...
Overall marginal bone loss was not significantly different between the two treatment groups (EHC vs. IHC) at any time point. The mean difference of bone levels between EHC and IHC was 0.25 mm (95% CI: −0.18 to 0.69) at implant placement. Mean difference between IHC and EHC was −0.01 mm (95% CI: −0.34 to 0.36) at 3 months, 0.13 mm (95% CI: −0.48 to 0.22) at 6 months and 0.11 mm (95% CI: −0.45 to 0.25) at 12 months. All the implants showed good periodontal health at the 1-year-in-function visit, with no statistically significant differences between groups. At 12 months mean (± standard deviation) PI was 2 (± 1.5) for the EHC and 1.85 (± 1.58) for the IHC group (P = 0.57) with a mean difference between the two groups of 0.15 (95% CI: −0.56 to 0.85). Mean PD was 2.23 mm (± 0.52) for the EHC and 2.10 mm (± 0.39) for the IHC group (P = 0.39), with a mean difference between the two groups of 0.12 mm (95% CI: −0.08 to 0.33). At 12 months 41.4% of EHC and 43.6% of IHC implants ...
Objective The aim of the present study was to assess interventions and their consequences with regard to further bone loss at sites diagnosed with peri-implantitis. Materials and Methods In 2017, records of 70 patients diagnosed with moderate/severe peri-implantitis at >= 1 implant sites 4 years earlier were obtained. Changes of marginal bone levels during the study period assessed on radiographs and predictors of disease progression were identified by Cox regression and mixed linear modelling. Patient files were analysed for professional interventions related to the treatment of peri-implantitis. Results Mean bone loss (+/- SD) at implants diagnosed with moderate/severe peri-implantitis was 1.1 +/- 2.0 mm over the observation period of 3.3 years. While non-surgical measures including submucosal and/or supra-mucosal cleaning of implants were provided to almost all patients, surgical treatment of peri-implantitis was limited to a subgroup (17 subjects). Surgically treated implant sites ...
The molecular mechanisms controlling the differentiation of bone marrow stromal stem cells into osteoblasts remain mainly unknown. Similar results were found for the knockdown of the receptor- knockdown cells than control cells. Our data provide the first evidence that is involved in the osteogenic differentiation of bone tissue marrow stromal cells the legislation of the signaling pathway. Launch Osteoblasts differentiate from bone tissue marrow stromal cells (BMSCs), also called mesenchymal stem cells, that have the capacity to be adipocytes or fibroblasts [1]. Lately, individual alveolar-derived BMSCs (hAD-BMSCs) have already been effectively isolated and cultured [2]. These cells could be ideal for periodontal bone tissue regenerative medication because marrow bloodstream can be quickly aspirated from alveolar bone tissue during tooth removal and oral implant medical procedures [3, 4]. The bone tissue morphogenetic proteins (BMP) 2 signaling pathway can be an important regulator of ...
Ferreira CEA, Novaes AB Jr, Haraszthy VI, Bittencourt M, Martinelli CB, Luczyszyn SM. A clinical study of 406 sinus augmentations with 100% anorganic bovine bone. J Periodontol 2009;80(12):1920-1927.. Sinus grafting with anorganic bovine bone was performed in 222 patients requiring unilateral sinus grafting and 92 patients requiring bilateral sinus grafting; a total of 1,025 implants were placed (118 simultaneous with grafting and 907 at second stage surgery after 6-12 months). After 3 years, the implant survival rate was 98.1% (19 implants were lost), with no significant differences in survival between implants with rough or machined surfaces, or between implants placed in various heights of native bone. Histomorphometry showed 39.0 ± 12% new bone formation and 52.9% ± 9.3% marrow space.. Song D-W, Lee D-W, Kim C-K, Park K-H, Moon I-S. Comparative analysis of peri-implant marginal bone loss based on microthread location: a 1-year prospective study after loading. J Periodontol ...
Results: One patient (11-mm group) died before the 12-month evaluation and one patient (6-mm group) moved away. In addition, one patient in the 6-mm group lost one implant and no implants were lost in the 11-mm group. Two patients lost three restorations in the 6-mm group and no restorations were lost in the 11-mm group. From loading until the 60-month assessment, the mean marginal bone loss in the 6-mm group and the 11-mm group was 0.12 ± 0.36 mm and 0.14 ± 0.63 mm, respectively, without a significant difference (mean difference 0.02 mm; 95% CI -0.32 to 0.37; P = 0.884). Implant loss, restoration loss, screw loosening and porcelain chipping were defined as complications. Four patients in the 6-mm group and one patient in the 11-mm group had one or more complications, without a significant difference between the groups (95% CI 0.019 to 0.244; P = 0.198). The patient satisfaction was high in both groups (mean overall satisfaction in the 6-mm and the 11-mm groups was 9.4 ± 0.8 and 9.2 ± 0.8, ...
Results: One patient (11-mm group) died before the 12-month evaluation and one patient (6-mm group) moved away. In addition, one patient in the 6-mm group lost one implant and no implants were lost in the 11-mm group. Two patients lost three restorations in the 6-mm group and no restorations were lost in the 11-mm group. From loading until the 60-month assessment, the mean marginal bone loss in the 6-mm group and the 11-mm group was 0.12 ± 0.36 mm and 0.14 ± 0.63 mm, respectively, without a significant difference (mean difference 0.02 mm; 95% CI -0.32 to 0.37; P = 0.884). Implant loss, restoration loss, screw loosening and porcelain chipping were defined as complications. Four patients in the 6-mm group and one patient in the 11-mm group had one or more complications, without a significant difference between the groups (95% CI 0.019 to 0.244; P = 0.198). The patient satisfaction was high in both groups (mean overall satisfaction in the 6-mm and the 11-mm groups was 9.4 ± 0.8 and 9.2 ± 0.8, ...
... involves progressive loss of the alveolar bone around the teeth, and if left untreated, can lead to the loosening ... Zadik Y, Bechor R, Shochat Z, Galor S; Bechor; Shochat; Galor (April 2008). "Ethnic origin and alveolar bone loss in Israeli ... of attachment loss Moderate: 3-4 mm (0.12-0.16 in) of attachment loss Severe: ≥ 5 mm (0.20 in) of attachment loss In the early ... periodontal surgery may be needed to stop progressive bone loss and regenerate lost bone where possible. Many surgical ...
Untreated, these diseases lead to alveolar bone loss and tooth loss. As of 2017[update], these continue to be one of the ... The supporting tissues are known as the periodontium, which includes the gingiva (gums), alveolar bone, cementum, and the ... including the treatment of peri-implantitis which is inflammatory bone loss around dental implants. The etiology of peri- ... combined with host immuno-inflammatory mechanisms and other risk factors which lead to destruction of the supporting bone ...
"Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice". Journal of Bone and Mineral Research. doi: ... "A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone ...
ISBN 81-89093-10-X. Liran, Levin (June 2007). "Alveolar Bone Loss and Gingival Recession Due to Lip and Tongue Piercing". N Y ... In some cases, the alveolar tooth-bearing bone is also involved, jeopardizing the stability and durability of the teeth in ... Bone, Angie; Fortune Ncube; Tom Nichols; Norman D Noah (21 June 2008). "Body Piercing in England: a Survey of Piercing at Sites ... It was popular among the Aztecs, the Mayans and the tribes of New Guinea, who adorned their pierced noses with bones and ...
Extension of the lesion into alveolar bone, periodontal ligament with significant bone loss Continued loss of collagen ... The disease consists of a chronic inflammation associated with loss of alveolar bone. Advanced disease features include pus and ... drifting and eventual loss Because bone loss makes its first appearance in the advanced lesion, it is equated with ... Features of the Established Lesion: Predominance of plasma cells without bone loss Presence of extravascular immunoglobulins in ...
This may further lead to furcal involvement through loss of clinical attachment and alveolar bone. A cursory clinical ... This is because neutrophils, which are rich sources of PGE2, are present when the majority of rapid bone loss occurs during the ... injured site and cause resorption of the periapical alveolar bone. It is possible that after conventional endodontic therapy ... Regeneration of the bone has been demonstrated to occur, on average, at a rate of 3.2 mm² per month, and studies suggest that ...
... is a procedure to reduce bone loss after tooth extraction to preserve the dental alveolus (tooth socket) in the alveolar bone. ... Alveolar bone is the bone that surrounds the roots of the teeth forming bone sockets. In mammals, tooth sockets are found in ... Polyphyodont Alveolar ridge Peck, Mogammad Thabit; Marnewick, Johan; Stephen, Lawrence (2011). "Alveolar Ridge Preservation ... Dental alveoli (singular alveolus) are sockets in the jaws in which the roots of teeth are held in the alveolar process with ...
In advanced cases the alveolar bone loss may be depicted as a horizontal bone loss pattern radiographically. Mostly in ... Loss of attachment refers to the destruction of periodontium whereas the bone refers to the alveolar bone supporting the teeth ... "Five-year alveolar bone level changes in women of varying skeletal bone mineral density and bone trabeculation". Oral Surgery, ... to the alveolar bone crest is typically in the order of 1mm in young people. If the distance between the ACJ and alveolar bone ...
This condition increase alveolar bone loss, attachment loss, tooth mobility, and finally tooth loss (McGuire &Nunn, 1996). It ... involvement in bone infections: a review. Int J Antimicrob Agents. 2013 Jun;41(6):509-15. Rogers MB, Parker AC, Smith CJ. 1993 ...
Untreated, these diseases can lead to alveolar bone loss and tooth loss. As of 2013[update], Periodontal disease accounted for ... Alveolar Bone[edit]. In periodontal health, the alveolar bone surrounds the teeth and forms the bony socket that supports each ... ongoing chronic stress are more likely to have clinical attachment loss and decreased levels of alveolar bone due to ... Alveolar bone D. Oral epithelium E. Attached gingiva F. Gingival margin G. Gingival sulcus H. Junctional epithelium I. Alveolar ...
Stippling only presents on the attached gingiva bound to underlying alveolar bone, not the freely moveable alveolar mucosa. ... unless it is smooth due to a loss of previously existing stippling. Stippling is a consequence of the microscopic elevations ...
Effect of dietary vitamin E supplement and rotational stress on alveolar bone loss in rice rats (subscription required). ... Effect of stannous fluoride and iodine on root caries and bone loss in rats. Ohio Journal of Science 88(3):99-100. Benson, D.E ... Vitamin E, fluoride, and iodide protect against bone loss associated with this disease in the rice rat and a high-sucrose diet ... The nasal and premaxillary bones extend back beyond the point where the lacrimal, frontal, and maxillary bones meet. In P. o. ...
They describe the development of lateral plates on the alveolar margins of tooth-bearing bones. These plates can be used to ... strip foliage, the eusauropod's "U-shaped" jaws create a wide bite, and their loss of "fleshy cheeks" increased the gape. The ... Unlike prosauropods and theropods, which have a snout with smooth, unprotruding alveolar and subnarial regions, eusauropods ...
Interproximal and horizontal alveolar bone loss in mouse models are seen in coinfections involving P. gingivalis and Treponema ... Vaccines made from P. gingivalis CPS apparently impair oral bone loss in murine models. These vaccines have been able to elicit ... In contrast, germ free mice inoculated with a P. gingivalis monoinfection incur no bone loss, indicating that P. gingivalis ... In these models, P. gingivalis inoculation causes significant bone loss, which is a significant characteristic of the disease. ...
... a procedure to reduce bone loss after tooth extraction to preserve the dental alveolus (tooth socket) in the alveolar bone. A ... PRF is used in guided bone and tissue regeneration PRF enhances alveolar bone augmentation and necrotic dental pulp and open ... "Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation". BioMed Research International ... platelet-rich fibrin (PRF) membrane containing bone growth enhancing elements can be stitched over the wound or a graft ...
"Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect ... this approach might provide some advantages in treatment of both cartilage and bone loss. The IVB concept needs to be however ... Upon exposure of the periosteal cells to calcium from the alginate gel, these cells become bone cells and start producing bone ... CS1 maint: Uses authors parameter (link) Bai M., Zhang T., Ling T., Zhou Z., Xie H., Zhang W., Wu H. (2013). "Guided bone ...
They are also attached to the gingival (gum) tissue that covers the alveolar bone by an attachment apparatus; because this ... Teeth are attached to the surrounding and supporting alveolar bone by periodontal ligament (PDL) fibers; these fibers run from ... Although this is technically a loss of clinical attachment, the term clinical attachment loss is used almost exclusively to ... of the alveolar bone, it is termed the supracrestal attachment apparatus. The supracrestal attachment apparatus is composed of ...
... a fracture of the alveolar process of the upper jaw bone which caused severe neurities [sic] with persistent neuralgic pain ... both day and night ... likewise causing the loss of all the teeth of the upper jaw on one side of the face." In 1914 she ...
A suprabony pocket occurs when there is horizontal bone loss, the bottom of the pocket is coronal to the alveolar bone. An ... infrabony pocket occurs when there is vertical bone loss where the bottom of the pocket is apical to the alveolar bone. ... pockets can cause the loosening and loss of dentition due to destruction of supporting tissues including the alveolar bone, PDL ... loss are considered pseudopockets.There are two types of periodontal pockets that are determined by the type of bone loss ...
If the tooth has pre-existing periodontal disease, with pockets and loss of alveolar bone height, it is more likely to be a ... The path of the infection is influenced by such things as the location of the infected tooth and the thickness of the bone, ... If left untreated, a severe tooth abscess may become large enough to perforate bone and extend into the soft tissue eventually ... In some cases, a tooth abscess may perforate bone and start draining into the surrounding tissues creating local facial ...
Loss of teeth alters the form of the alveolar bone in 91% of cases. In addition to this resorption of bone in the vertical and ... bone loss, presenting with a distal horizontal defect and a mesial vertical defect. Tooth #22 exhibits roughly 30% bone loss. ... The alveolar bone is unique in that it exists for the sake of the teeth that it retains; when the teeth are absent, the bone ... Bone loss with missing teeth, partials and complete dentures is progressive. According to Wolff's law, bone is stimulated, ...
This condition increase alveolar bone loss, attachment loss, tooth mobility, and finally tooth loss.[4] It can cause other ... involvement in bone infections: a review. Int J Antimicrob Agents. 2013 Jun;41(6):509-15. ...
In cases where recession is not accompanied by periodontal bone loss, complete or near complete coverage of the recession area ... It may exist with or without concomitant decrease in crown-to-root ratio (recession of alveolar bone). Various classifications ... Gingival recession, also known as receding gums, is the exposure in the roots of the teeth caused by a loss of gum tissue and/ ... This material is usually combined with the cellular matrix to form a soft bone paste that is then covered by the allograft. The ...
Depths greater than 3 mm can be associated with "attachment loss" of the tooth to the surrounding alveolar bone, which is a ...
... implants exhibited less-than-expected initial crestal bone loss-the effect of bone modeling at the crest of the alveolar bone ... "bone loss to the first thread." This vertical loss of bone (X in the diagram at right) diminishes the bone-to-implant contact, ... the lateral extent of this vertical bone loss around implants has been investigated-in other words, the thickness of bone loss ... allowing for a reduction in the horizontal extent of bone loss. Canullo L, et al. Platform switching and marginal bone-level ...
"Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation ( ... In the case of allogeneic transplants, fresh HSC are preferred in order to avoid cell loss that might occur during the freezing ... alveolar hemorrhage, and allergic reactions (usually expressed in first 30 minutes, risk 1 in 300).[43][44][45] In addition, ... In the case of a bone marrow transplant, the HSC are removed from a large bone of the donor, typically the pelvis, through a ...
Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ... Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ... Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ... Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar ...
... were subjected to quantitative radiographic evaluation of alveolar bone loss and tooth loss. There was a high prevalence of ... A significant positive interaction between alveolar bone loss and tooth loss (P < 0.01), implies that the highly prevalent ... were subjected to quantitative radiographic evaluation of alveolar bone loss and tooth loss. There was a high prevalence of ... A significant positive interaction between alveolar bone loss and tooth loss (P < 0.01), implies that the highly prevalent ...
... host immune responses to dysregulated microbiota in dental biofilms leading to degradation of tissues and alveolar bone loss. ...
that the periotest value dependent to a large extent on bone. loss. The greater the alveolar bone height, the lower the. ... 7. Bone factor concept of Glickman: When a generalized. tendency toward bone resorption exists, bone loss initiated. by local ... systemic influence on the response of alveolar bone has been. termed the bone factor in periodontal disease. The bone. factor ... 1. Bone loss or loss of tooth support:. 2. Trauma from occlusion:. 3. Hypofunction:. 4. Extension of inflammation from the ...
... periodontitis can lead to progressive loss of the periodontal bone and subsequent tooth loss [2]. The ultimate goal of ... is located between teeth and alveolar bone and plays an integral role in the maintenance and regeneration of periodontal tissue ... Enhanced bone regeneration with a gold nanoparticle-hydrogel complex. J Mater Chem B Mater Biol Med. 2014;2:1584-93 ... J Bone Miner Res. 2013;28:2414-30 24. Li J, Li JJ, Zhang J, Wang X, Kawazoe N, Chen G. Gold nanoparticle size and shape ...
Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the ... B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection. Pamela J. Baker,1 Nicole Ryan Boutaugh,1 ... contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB/cJ mice and IgD deficient BALB ... Specific antibody to P. gingivalis was lower and oral colonization was higher in IgD deficient mice; yet bone loss was ...
"Alveolar Bone Loss" by people in Harvard Catalyst Profiles by year, and whether "Alveolar Bone Loss" was a major or minor topic ... Annual alveolar bone loss in older adults taking oral bisphosphonate: a retrospective cohort study. BMC Oral Health. 2019 11 27 ... "Alveolar Bone Loss" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Prevalence of periodontitis and alveolar bone loss in a patient population at Harvard School of Dental Medicine. BMC Oral ...
403 Bis-enoxacin Inhibited Alveolar Bone Loss and Gingival Inflammation in Rats Thursday, March 22, 2012: 2 p.m. - 3:15 p.m. ... and alendronate in inhibiting osteoclast alveolar bone resorption (ABR) in a polymicrobial periodontal disease rat model. ... Similarly, enoxacin-linked bisphosphonate, bis-enoxacin, inhibits osteoclast formation and bone resorption. Periodontal ...
Quantify periodontal alveolar bone loss rates in postmenopausal women.. II. Evaluate the effects of estrogen on alveolar bone ... Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss. The safety and ... Comparison of reliability of manual and computer-intensive methods for radiodensity measures of alveolar bone loss. ... loss rates in these patients.. III. Determine whether changes in periodontal bone mass relate to bone mass changes in other ...
Quantify periodontal alveolar bone loss rates in postmenopausal women.. II. Evaluate the effects of estrogen on alveolar bone ... Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss. The safety and ... Phase III Randomized Study of the Effect of Postmenopausal Estrogen Replacement Therapy on Alveolar Bone Loss. ... Comparison of reliability of manual and computer-intensive methods for radiodensity measures of alveolar bone loss. ...
... severe alveolar bone loss ranging between 1/3 and 2/3 of the normal alveolar bone height (group 4), or alveolar bone loss ... gingivitis without signs of alveolar bone loss (group 2), moderate alveolar bone loss not exceeding 1/3 of the normal alveolar ... Mean alveolar bone loss varied between 1.51 mm and 2.64 mm depending on smoking status and age. Mean alveolar bone loss was ... Alveolar bone loss was recorded if the distance from the cemento-enamel junction to the alveolar crest exceeded 2 mm measured ...
Effect of Ratio of Residual Alveolar Bone to Graft Material in Contact With Fixture Surface on Marginal Bone Loss of Implants ... The residual bone/implant length ratio and the residual bone/implant area ratio were not associated with marginal bone loss at ... The residual bone/implant length ratio and residual bone/implant area ratio were not associated with marginal bone loss around ... study was to evaluate the influences of height or area ratio of residual alveolar bone to graft material on marginal bone loss ...
... ... as well as severe hypertension and alveolar bone loss (ABL) in older adults. ... Direct measures of alveolar bone level were recorded using CT scans, and different variables were studied (age, sex, Plaque ... The results confirmed a positive association between CHD/VD and periodontal destruction; alveolar bone destruction represented ...
... Grethe Jonasson, Marianne Rythén*Clinical Cosmetic and ...
Morphometric registration of alveolar bone loss was carried out after 30 days of ligature placement to determine the effect of ... Objective: The purpose of this study was to investigate the effect of obesity on alveolar bone loss in experimental ... Objective: The purpose of this study was to investigate the effect of obesity on alveolar bone loss in experimental ... Effect of obesity on alveolar bone loss in experimental periodontitis in Wistar rats. ...
Nakano, M. (2009). Idiopathic external root resorption with alveolar bone loss: Case report and microbiological evaluation. ... Nakano, M 2009, Idiopathic external root resorption with alveolar bone loss: Case report and microbiological evaluation, ... Idiopathic external root resorption with alveolar bone loss: Case report and microbiological evaluation. / Nakano, Michiyo. ... Idiopathic external root resorption with alveolar bone loss: Case report and microbiological evaluation. In: Pediatric Dental ...
Alveolar bone lossAlveolar bone levels are evaluated by clinical and radiographic examination. • Probing is helpful for ... The periodontal pocket is a soft tissue change • Radiographs indicate areas of bone loss where pockets may be suspected but : 1 ... Changes in the level of attachment can be due only to gain or loss of attachment and afford a better indication of the degree ... If both are the same, the loss of attachment is zero • When the gingival margin coincides with the cementoenamel junction, the ...
Results: The measurements of alveolar bone loss in the mandibular molars revealed significantly higher bone-loss values in the ... Alveolar bone loss was measured. Interleukin 1 beta (IL-1 beta) and interleukin 10 (IL-10) were evaluated in the serum samples ... The aim of this study was to evaluate the effects of systemic curcumin therapy on alveolar bone loss in an experimental ... Effects of Curcumin on Alveolar Bone Loss in Experimental Periodontitis in Rats: A Morphometric and Histopathologic Study ...
The polymicrobial infection triggered significant alveolar bone loss, a heightened antibody response, an elevated cytokine ... Associations were found between bone loss, specific viral and bacterial species, immune genes, and PDL space changes. These ... Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of a polymicrobial ... changes in bone loss, the host immune response, and the microbiome/virome using shotgun sequencing. Periodontal pathogens, ...
Alveolar Bone Loss. *Bad Taste in Mouth. *Black Hairy Tongue. *Bonding Disorders ...
Alveolar Bone Loss. *Anodontia. *Bad Taste in Mouth. *Bleeding Gums. *Bonding Disorders ...
Bone Loss, Alveolar Tooth Loss Bone Atrophy, Alveolar Procedure: AUTOTRANSPLANTATION TOOTH Not Applicable ... Alveolar Bone Loss. Tooth Loss. Atrophy. Pathological Conditions, Anatomical. Periodontal Diseases. Mouth Diseases. ... Change in alveolar bone 12 months after tooth autotransplantation [ Time Frame: 1 year ]. CT-scan evaluation before surgery and ... Tooth Autotransplantation and Bone Dimension Changes. The safety and scientific validity of this study is the responsibility of ...
... the periodontal ligament and alveolar bone). It is highly prevalent... ... pattern of bone loss. Some of the teeth have lost nearly all their supporting alveolar bone as a result of periodontitis ... Alveolar bone levels are normal, with the crest of the alveolar bone being in close proximity to the cemento-enamel junction ( ... Risk indicators for alveolar bone loss. J Periodontol 66:23-29PubMedCrossRefGoogle Scholar ...
Alveolar ridge preservation (ARP) has been shown to prevent postextraction bone loss. The aim of this report is to highlight ... Alveolar Ridge Preservation Using Xenogeneic Collagen Matrix and Bone Allograft. Andreas O. Parashis,1,2 Charalampos J. ... The XCM was adapted to cover the defect and 2-3 mm of adjacent bone and flaps were repositioned. Healing was uneventful in all ... Radiographic and clinical assessment indicated adequate volume of bone for implant placement, with all planned implants placed ...
Animals , Male , Alveolar Bone Loss/pathology , Periodontitis/etiology , Periodontitis/pathology , Alveolar Bone Loss/ ... and kinetics of the alveolar bone-loss measurement methodologies i Agreement, correlation, and kinetics of the alveolar bone- ... Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Alveolar Bone Loss Type of study: Evaluation ... Full text: Available Index: LILACS (Americas) Main subject: Periodontitis / Alveolar Bone Loss Type of study: Evaluation ...
  • As seen in ankylosed tooth after failing replantation or if autogenous bone grafts are placed in contact with detached root surface. (scribd.com)
  • 11 ] showed that AuNPs facilitated the differentiation of bone marrow-derived mesenchymal stem cells (MSCs) towards osteoblast over adipocytes through activating the p38 MAPK signaling pathway. (thno.org)
  • Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar bone on the 2 molars between which the injections were made, and by measuring the ratio of root area/enamel area in the same region. (nebraska.edu)
  • Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. (nih.gov)
  • They found that bone loss in the jaw correlated with the severity of localized inflammation in the joints of the mice. (elsevier.com)
  • Conclusion: This study demonstrates that systemic administration of curcumin at the 75 and 150mg/kg doses reduced alveolar bone loss in the periodontal disease in rats. (cumhuriyet.edu.tr)
  • The aim was to correlate alveolar bone loss in the buccal/palatal and the mesial/distal surfaces of upper molars in rats . (bvsalud.org)
  • Alveolar Bone Loss" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The objective of this study was to utilise a new methodological approach based on radiographic examinations to demonstrate a potential association between coronary heart diseases (CHD) as well as severe hypertension and alveolar bone loss (ABL) in older adults. (ovid.com)
  • You won't find an environmental cause for any bone cancer apart from the rare ones that arise in pre-existing severe Paget's of bone, rare genetic syndromes or an old radiation port. (healthtap.com)
  • The extent of bone loss was more severe in the ACS group than in the non-ACS group. (eurekalert.org)
  • Results showed that women infected with four bacteria known to cause periodontal disease were more likely to have more severe oral bone loss than those without these oral pathogens. (bio-medicine.org)
  • Four Cases of Preprosthetic Surgery for Patients with Severe Absorption and/or Loss of the Alveolar Bone. (nii.ac.jp)
  • Research has shown that activation of MC receptors by ACTH or other MC peptides can lead to a variety of protective actions against bone loss, including increased matrix deposition, reduced osteoclast activation, and enhanced proliferation of bone-forming cells. (elsevier.com)
  • Journal Article] Lineage-committed osteoclast precursors circulate in blood and settle down into bone. (nii.ac.jp)
  • Increased IgE + B Cells in Sputum, but Not Blood, Bone Marrow, or Tonsils, after Inhaled Allergen Challenge in Subjects with Asthma. (nih.gov)
  • Bony mets can cause bony pain ( depending on the location), fractures, spinal cord compression resulting in significant nerve deficits on extremities/weakness/can develop paralysis etc, suppresion to the blood counts if cancer also involves the bone marrow etc. (healthtap.com)
  • What causes bone marrow tumors to form? (healthtap.com)
  • There are multiple different types of bone marrow tumors and the cause for almost all is unknown. (healthtap.com)
  • Bone implants were generated from osteoblasts induced from bone marrow progenitor cells obtained from the same pig, seeded onto PLGA fused wafer scaffolds, and grown for 10 days in a rotational oxygen-permeable bioreactor system. (mendeley.com)
  • Morphometric registration of alveolar bone loss was carried out after 30 days of ligature placement to determine the effect of obesity on the progression of experimental peiodontitis. (ufrgs.br)
  • Morphometric analysis was used to evaluate alveolar bone loss. (biomedcentral.com)
  • Its anatomy is important for evaluating the morphometric symmetry of the mental triangle, microscopic and macroscopic morphology and maturity of the human mandible, bone remodeling activity and paleoanthropologic features of the facial skeleton in different populations. (ispub.com)
  • Alveolar bone loss was measured according to standard methods by determining both the distance between the CEJ and the alveolar bone on the 2 molars between which the injections were made, and by measuring the ratio of root area/enamel area in the same region. (nebraska.edu)
  • The cemento- enamel junction ( CEJ ) was stained with 1% methylene blue and the alveolar bone loss in the buccal/palatal surfaces was measured linearly in 5 points on standardized digital photographs. (bvsalud.org)
  • A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. (biomedsearch.com)
  • Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone mineral (EMP/BPBM group). (biomedsearch.com)
  • Histological and immunohistochemical analyses of the excised hybrid tooth-bone constructs revealed the presence of tooth tissues, including primary and reparative dentin and enamel in the tooth portion of hybrid tooth-bone implants, and osteocalcin and bone sialoprotein-positive bone in the bone portion of hybrid tooth-bone constructs. (mendeley.com)
  • The articles included in the analysis were published in the English language and reported data on the use of implants with lengths below 10 mm in the posterior region with reduced alveolar bone height making the placement of longer implants impossible without additional surgical interventions. (medscimonit.com)
  • It was found that MT01, one of the ODNs with the sequences of human mitochondrial DNA, stimulated the proliferation of BMSCs, the differentiation of BMSCs to osteoblasts and mRNA expression of bone-associated factors including Runx2, Osterix, OPG, RANKL and collagen I in vitro . (mdpi.com)
  • A positive correlation was found between alveolar bone loss in buccal/palatal and proximal surfaces. (bvsalud.org)
  • Areas with and without ligature -induced periodontal destruction allow detection of alveolar bone loss in buccal/palatal and proximal surfaces. (bvsalud.org)
  • The biological plausibility has been well documented, and the best evidence suggests the potential influence of diabetes on periodontal disease is likely explained by 1 ) a hyperinflammatory response to infection, 2 ) uncoupling of bone destruction and repair, and/or 3 ) the effects of advanced glycation end products ( 10 , 11 ). (diabetesjournals.org)
  • Although bacterially-mediated mechanisms of alveolar bone destruction have been widely studied, the effects of a polymicrobial infection on the periodontal ligament and microbiome/virome have not been well explored. (nature.com)
  • Changes in the PDL space were present at sites far away from the site of insult, indicating that the polymicrobial radius of effect extends beyond the bone loss areas and site of initial infection and wider than previously appreciated. (nature.com)
  • Using mice deficient in NCR1 (the mouse orthlogue of NKp46), we demonstrate that oral infection of mice with F. nucleatum , but not with P. gingivalis results in an NCR1-dependent alveolar bone loss. (pubmedcentralcanada.ca)
  • Annual alveolar bone loss in older adults taking oral bisphosphonate: a retrospective cohort study. (harvard.edu)
  • Participants in the placebo group may be removed from study if bone loss exceeds 5% per year. (clinicaltrials.gov)
  • Regression analyses were performed to study the relationship between smoking duration and alveolar bone loss. (arctichealth.org)
  • To test this hypothesis, the relationship between smoking duration and alveolar bone loss should be studied in a prospective study design. (arctichealth.org)
  • In this study, 42 patients with Astra implants in sinuses that had been augmented with alloplasts and allografts or xenografts (alveolar bone height ≤ 5 mm) were selected. (ovid.com)
  • The Toronto Study: Bone Level Changes. (ebscohost.com)
  • It is considered a highly suitable model to study bone remodeling activity and the maturity pattern of the human mandible.Its modal position varies according to age and race and has been cited ranging from sub canine to sub molar in different populations. (ispub.com)
  • In this pilot study the research protocol for an in vivo experiment with a new calcium phosphate bone augmenting ceramic material, was evaluated. (uppsatser.se)
  • Apart from the pilot study, the master thesis includes a literature review of dental implants, bone augmenting materials and how the rabbit can be used as an animal model in dental implant research. (uppsatser.se)