Nitroprusside: A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.Ferricyanides: Inorganic salts of the hypothetical acid, H3Fe(CN)6.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Nitric Oxide Donors: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Forearm: Part of the arm in humans and primates extending from the ELBOW to the WRIST.Hypotension, Controlled: Procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Phenylephrine: An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.Vasoconstrictor Agents: Drugs used to cause constriction of the blood vessels.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Guanylate Cyclase: An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2.Trimethaphan: A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery.Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.Arginine: An essential amino acid that is physiologically active in the L-form.S-Nitroso-N-Acetylpenicillamine: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Nitroarginine: An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.OxadiazolesMolsidomine: A morpholinyl sydnone imine ethyl ester, having a nitrogen in place of the keto oxygen. It acts as NITRIC OXIDE DONORS and is a vasodilator that has been used in ANGINA PECTORIS.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Vasoconstriction: The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.Bradykinin: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.Baroreflex: A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.Muscle, Smooth, Vascular: The nonstriated involuntary muscle tissue of blood vessels.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.Arterioles: The smallest divisions of the arteries located between the muscular arteries and the capillaries.Plethysmography: Recording of change in the size of a part as modified by the circulation in it.Methylene Blue: A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.Norepinephrine: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Vasomotor System: The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.Infusions, Intra-Arterial: Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.PurinonesCromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)Mesenteric Arteries: Arteries which arise from the abdominal aorta and distribute to most of the intestines.Arteries: The vessels carrying blood away from the heart.Iontophoresis: Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.Nitroso CompoundsRats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Aorta: The main trunk of the systemic arteries.15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid: A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)Dibutyryl Cyclic GMP: N-(1-Oxobutyl)-cyclic 3',5'-(hydrogen phosphate)-2'-butanoate guanosine. A derivative of cyclic GMP. It has a higher resistance to extracellular and intracellular phosphodiesterase than cyclic GMP.Sympathetic Nervous System: The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)QuinoxalinesCoronary Vessels: The veins and arteries of the HEART.Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.Pressoreceptors: Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Sodium Nitrite: Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.Cyclic GMP-Dependent Protein Kinases: A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Laser-Doppler Flowmetry: A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.S-Nitrosoglutathione: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.Hydroxocobalamin: Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.Biological Factors: Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.Amino Acid Oxidoreductases: A class of enzymes that catalyze oxidation-reduction reactions of amino acids.Rats, Inbred WKY: A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Muscle, Smooth: Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.Injections, Intra-Arterial: Delivery of drugs into an artery.Prostaglandin Endoperoxides, Synthetic: Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Muscle Tonus: The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).Benzopyrans: Compounds with a core of fused benzo-pyran rings.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.HydrazinesCardiac Output: The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).Pulmonary Circulation: The circulation of the BLOOD through the LUNGS.Apamin: A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Rats, Inbred SHR: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.Antihypertensive Agents: Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.Methoxamine: An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.DiethylaminesBasilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
It can also be caused by breakdown of nitroprusside into nitric oxide and cyanide. Nitroprusside may be used during treatment ... "Sodium Nitroprusside". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. ... the medication nitroprusside, and certain seeds such as those of apples and apricots. Liquid forms of cyanide can be absorbed ...
It has been associated with nitroprusside. Coronary arteriovenous fistula between coronary artery and another cardiac chamber, ...
Solution A: Dissolve 1 g of sodium nitroprusside in 50 mL of distilled water and add 2 mL of acetaldehyde to the solution with ... The reagent is composed of a mixture of sodium nitroprusside, sodium carbonate and acetaldehyde, which is dripped onto the ... Leeuwenkamp, O. R.; van Bennekom, W. P.; van der Mark, E. J.; Bult, A. (1984). "Nitroprusside, antihypertensive drug and ... The amine and acetaldehyde produce the enamine, which subsequently reacts with sodium nitroprusside to the imine. Finally, the ...
... s include: hydralazine minoxidil nitroprusside. ...
Molsidomine and nitroprusside already contain nitrogen in the right oxidation state (+2) and liberate NO without the aid of ... Nitroprusside is used intravenously for the treatment of hypertensive crises, heart failure, and lowering of blood pressure ... Nitroprusside, given intravenously, acts immediately, and after stopping the infusion blood pressure returns to its previous ... CS1 maint: Multiple names: authors list (link) Sodium nitroprusside: Monograph. Tanaka, Y.; Tang, G.; Takizawa, K.; Otsuka, K ...
Bernshtein, V N; Belikov, V G (1961). "Sodium Nitroprusside and Its Use in Analysis". Russian Chemical Reviews. 30 (4): 227. ...
"Elevated carboxyhemoglobin associated with sodium nitroprusside treatment". Intensive Care Med. 31 (9): 1235-8. doi:10.1007/ ...
In most cases, the administration of intravenous sodium nitroprusside injection which has an almost immediate antihypertensive ... compared to sodium nitroprusside. In addition, non-pharmacological treatment could be considered in cases of resistant ... such as with sodium nitroprusside infusions), while urgencies can be treated with oral agents, with the goal of lowering the ... effect, is suitable (but in many cases not readily available). Besides, nitroprusside runs a risk of cyanide poisoning. Other ...
Sulfides also turn solutions of red sodium nitroprusside purple. Sulfites produce SO2 gas, which smells of burning sulfur, when ...
Arteriolar vasodilator Cadralazine Dihydralazine Endralazine Sodium nitroprusside "Hydralazine Hydrochloride". The American ...
Those based on sodium nitroprusside and the ruthenium sulfoxide compounds. The ruthenium sulfoxide complexes were created and ...
Nitroprusside - an arteriolar and venous dilator, given as an intravenous infusion. Nitroprusside acts within seconds and has a ... This may be done with labetalol or sodium nitroprusside given by injection into a vein. In those who are pregnant, magnesium ... However, the potential for cyanide toxicity limits the prolonged use of nitroprusside, particularly in patients with renal ... A comparison of intravenous nicardipine and sodium nitroprusside in the immediate treatment of severe hypertension. Am J ...
The most specific test is the cyanide-nitroprusside test Ultrasound/CT scan to reveal if a stone is present. Genetic analysis ... The stones may be identified by a positive nitroprusside cyanide test. The crystals are usually hexagonal, translucent, white. ...
Among the many 3-dimensional structures Coppens characterized is the nitroprusside ion. Coppens was a püioneer in the field of ...
Among his earlier works was a treatise on nitroprussides (1868). In 1880 he published a study on the correlation between the ...
Sodium nitroprusside, a metabolite of which is thiocyanate, is however still used for the treatment of a hypertensive emergency ... Rhodanese catalyzes the reaction of sodium nitroprusside with thiosulfate to form the metabolite thiocyanate. Thiocyanate ...
... red crystals of sodium nitroprusside can be selectively crystallized. Upon treatment with chlorine gas, potassium ferrocyanide ...
The test used in the urine test strips is based on the reaction of sodium nitroprusside (nitroferricyanide). In this reaction ... Sodium nitroprusside + Acetoacetic acid + Alkali medium → Pink-magenta complex + Water The test does not measure beta- ... the acetoacetic acid in an alkali medium reacts with the sodium nitroprusside producing a magenta coloured complex: Na2[Fe(CN) ...
... nitroprusside, and electrical stimulation". Neurourology and Urodynamics. 14 (2): 153-68. doi:10.1002/nau.1930140208. PMID ...
Conversely, hypertension or tachycardia can be treated with short-acting antihypertensive drugs such as nitroprusside or ...
Nitroprusside or phenylephrine may be used in those with decompensated heart failure depending on the blood pressure. Aortic ...
... tolazoline or nitroprusside. Papaverine is also being investigated as a topical growth factor in tissue expansion with some ...
"A comparison of fenoldopam with dopamine and sodium nitroprusside in patients undergoing cross-clamping of the abdominal aorta ...
Hodsman NB, Colvin JR, Kenny GN (May 1989). "Effect of ketanserin on sodium nitroprusside requirements, arterial pressure ...
"Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets". ...
... safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside ... RESULTS: The heart rate and amount of sodium nitroprusside used were highly significantly less (P , .01) in the propranolol ... CONCLUSION: Premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside is safe and ... Hemodynamic variables, the amount of sodium nitroprusside used, and blood loss were statistically analyzed. ...
... induced under general anaesthesia with intravenous sodium nitroprusside, was used in 3 cases and resulted in no vitreous loss ...
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The nitroprusside reaction is a chemical test used for detecting the presence of free thiol groups of cysteine in proteins. ... The nitroprusside reaction is usually used for the identification of ketones in urine testing. Chatterjea (1 January 2004). ... Proteins with the free thiol group give a red colour when added to sodium nitroprusside with ammonium hydroxide. Some proteins ...
Sodium nitroprusside crystals are also of interest for optical storage. For this application, sodium nitroprusside can be ... Sodium nitroprusside is also useful in the identification the mercaptans (thiol groups) in the nitroprusside reaction. Sodium ... Treatment of sodium nitroprusside overdose includes the following: Discontinuing sodium nitroprusside administration Buffering ... Sodium nitroprusside is used in a separate urinalysis test known as the cyanide nitroprusside test or Brands test. In this ...
For the March 6, 2017 meeting of the FDAs Pediatric Advisory Committee. Persons with disabilities having problems accessing any of the PDF files below may call 240-402-3838 for assistance. ...
A list of US medications equivalent to Sodium Nitroprusside Hydrate is available on the Drugs.com website. ... Sodium Nitroprusside Hydrate is a medicine available in a number of countries worldwide. ... Nitroprusside. Sodium Nitroprusside Hydrate (JAN) is known as Nitroprusside in the US. ... Sodium Nitroprusside Hydrate may be available in the countries listed below.. Ingredient matches for Sodium Nitroprusside ...
Learn about the potential side effects of nitroprusside. Includes common and rare side effects information for consumers and ... Applies to nitroprusside: intravenous powder for solution, intravenous solution. Along with its needed effects, nitroprusside ... Check with your doctor or nurse immediately if any of the following side effects occur while taking nitroprusside:. Less common ... and hypervolemia associated with nitroprusside. The oliguria and azotemia resolved after nitroprusside withdrawal. The patient ...
This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.. ...
Nitroprusside Sodium) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... sodium nitroprusside) Fliptop Vial for Injection. NITROPRESS® (Sodium Nitroprusside Injection) is not suitable for direct ... Nitroprusside-induced hypotension will be self-limited within 1-10 minutes after discontinuation of the nitroprusside infusion ... The mechanism of tachyphylaxis to sodium nitroprusside remains unknown.. Pediatric. The effects of sodium nitroprusside to ...
Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia] ... Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules ( ... Sodium nitroprusside is more active on veins than on arteries.. Mechanism of action. One molecule of sodium nitroprusside is ... Nitroprusside may increase the hypotensive activities of Fenoldopam.. Approved. Ferulic acid. Nitroprusside may increase the ...
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Sodium nitroprusside , C5H4FeN6Na2O3 , CID 11953895 - structure, chemical names, physical and chemical properties, ...
Sodium nitroprusside has proved to be the most effective and best-tolerated vasodilator drug available for the management of ... Successful Treatment of Neuroleptic Malignant Syndrome with Sodium Nitroprusside Annals of Internal Medicine; 104 (1): 56-57 ... Lactic Acidosis Complicating Sodium Nitroprusside Therapy Annals of Internal Medicine; 88 (1): 58-59 ... Effect of Progressive Pressure Reduction with Nitroprusside on Acute Myocardial Infarction in Humans: Determination of Optimal ...
... Pharmacological Interventions to Treat and Prevent Psychosis. ... Animal and human research supports that CBD and sodium nitroprusside might be effective in the prevention and treatment of ... The evidence available to date shows that CBD and sodium nitroprusside act in pathways associated with psychotic symptoms and ... and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. ...
Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... Intravenous fenoldopam versus sodium nitroprusside in patients with severe hypertension.. E Reisin, M M Huth, B P Nguyen, S G ... The detection of toxic levels of thiocyanate in two patients treated with nitroprusside, however, shows that fenoldopam might ...
Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This ... Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). Nitroprusside ... Nitroprusside is injected into a vein through an infusion pump. You will receive this injection in a clinic or hospital setting ... Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This ...
Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the ... The researchers found that the absolute number of patients treated with nitroprusside or isoproterenol decreased by 53 and 35 ... Nitroprusside, Isoproterenol Prescribing Drops With Price Rise. Last Updated: August 10, 2017. ... 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use ...
The effect of nitroprusside on IUD insertion experience in nulliparous women: a pilot study. Contraception. 2013 Apr;87(4):421- ... The Effect of Nitroprusside on Intrauterine Device (IUD) Insertion. This study has been completed. ... The Effect of Nitroprusside on the IUD Insertion Experience in Nulliparous Women: a Pilot Study. ... half of the subjects will receive nitroprusside gel for IUD insertion and the other half will receive a placebo gel. ...
SODIUM NITROPRUSSIDE, DIHYDRATE, ACS, Sodium Nitroprusside, Dihydrate, Sodium Nitroprusside, 0.5 g/L, Sodium Nitroprusside,.. ... Synonyms: Nitroprusside sodium; SNP; Sodium nitroprusside; Sodium pentacyanonitrosylferrate Formula: Na2[Fe(CN)5NO] · 2H2O ... FLUKA Sodium nitroprusside dihydrate Honeywell. purum p.a., ≥98.0% (AT) Synonym(s): Nitroprusside sodium; SNP; Sodium ... FLUKA Sodium nitroprusside dihydrate, purum p.a., =98.0% (AT) Honeywell. Synonyms: Nitroprusside sodium; SNP; Sodium ...
Renal effects of nitroprusside and hydralazine in patients with congestive heart failure.. J J Cogan, M H Humphreys, C J ... Nitroprusside had a more profound effect on pulmonary artery pressure, while hydralazine produced a greater elevation in ... Renal effects of nitroprusside and hydralazine in patients with congestive heart failure. ... The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in ...
Lactic Acidosis Complicating Sodium Nitroprusside Therapy STEPHEN H. HUMPHREY, M.D.; DANIEL A. NASH JR., M.D., F.A.C.P. ... Sodium nitroprusside has gained acceptance in the treatment of hypertensive emergencies and low cardiac-output syndromes ... Lactic Acidosis Complicating Sodium Nitroprusside Therapy. Ann Intern Med. 1978;88:58-59. doi: 10.7326/0003-4819-88-1-58 ... We describe a case in which sodium nitroprusside therapy of uncontrolled hypertension was complicated by the development of ...
Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial ... Nitroprusside / pharmacology*. Norepinephrine / blood*. Peptides / pharmacology*. Potassium / blood. Renin-Angiotensin System ... Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial ... 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 60-27-5/Creatinine; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor ...
Contact to Sodium Nitroprusside Exporters in India, Sodium Nitroprusside Wholesalers, Sodium Nitroprusside Distributors and ... Search Indian Sodium Nitroprusside Manufacturers and Suppliers Details - ... Deals in sodium nitroprusside, Ninhydrin, Dimethylglyoxime, 1, Maleic Hydrazide, Dithizone, Guanidine Thiocyanate, Lithium ... Deals in 5 Sulfosalicylic Acid, Sodium Bismuthate, Calcium Pyruvate, Sodium Nitroprusside, Sodium Pyruvate, Ethyl Pyruvate, 3 ...
Sodium nitroprusside is a nitric oxide donor that could potentially alter MMP activity via vasodilation in vivo, but can also ... Moreover, sodium nitroprusside 3 µM was able to overcome the decrease in MMP activity that occurred with hydrogen sulfide 40 µM ... We hypothesized that hydrogen sulfide reduced activity of MMP in ex vivo bone tissue homogenates and that sodium nitroprusside ... Results: Our data showed increased MMP activity at a sodium nitroprusside concentration of 1 µM, and MMP activity increased ...
NitropressVasodilatorHypotensionInfusionNitric oxide donorHypertensionCongestive heart fDihydrateToxicity of sodium nitroprussideArterial pressureSide effects of nitroprussideInjectionVasodilationAcetylcholineDavis's Drug GuideAllergy to nitroprussideAdministration of nitroprussideHypotensiveNIPRIDE2020IsoproterenolLeft ventricularHemodynamicNitroglycerinVialGeneric NameHypertensiveMechanismHemoglobinMoleculeMicrogramsNorepinephrinePatientsArteriesPotassiumPhenylephrineDiscontinuationTherapyPregnancyIncreasesCyanide ions
- Sodium nitroprusside (SNP), sold under the brand name Nitropress among others, is a medication used to lower blood pressure. (wikipedia.org)
- NITROPRESS® (Sodium Nitroprusside Injection) is not suitable for direct injection. (rxlist.com)
- Product Information: NITROPRESS(R) injection, sodium nitroprusside injection. (rxwiki.com)
- In an aqueous solution infused intravenously, sodium nitroprusside is a rapid-acting vasodilator, active on both arteries and veins. (rxlist.com)
- Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). (drugbank.ca)
- Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins. (drugbank.ca)
- Sodium nitroprusside has proved to be the most effective and best-tolerated vasodilator drug available for the management of acute hypertension, heart failure, and other vasoconstricted states as well as for the induction of controlled hypotension during surgery. (annals.org)
- Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). (everydayhealth.com)
- Nipride is nitroprusside a vasodilator (means open up blood vessels) which is used to lower blood pressure . (healthtap.com)
- The three most common drugs employed for acute vasodilator intervention are nitroprusside, nitroglycerin, and nesiritide. (endocrinologyadvisor.com)
- Nitroprusside is a powerful vasodilator. (endocrinologyadvisor.com)
- Because it is a powerful vasodilator, physicians are reluctant to prescribe nitroprusside routinely. (endocrinologyadvisor.com)
- For acute reduction of arterial pressure, the potent vasodilator sodium nitroprusside is very effective. (medscape.com)
- Sodium nitroprusside is an older intravenous vasodilator appropriate for acute hospital treatment of patients with congestive heart failure. (elsevier.com)
- A particular vasodilator , the nitroprusside of sodium . (wiktionary.org)
- Nitroprusside toxicity may present as hypotension, cyanide toxicity, or thiocyanate toxicity. (drugs.com)
- Sodium nitroprusside is also indicated for producing controlled hypotension in order to reduce bleeding during surgery. (rxlist.com)
- Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. (drugbank.ca)
- Metabolic acidosis complicating sodium nitroprusside-induced hypotension has been encountered in isolated clinical experiences (2) as well as an animal study (3). (annals.org)
- We describe a case in which sodium nitroprusside therapy of uncontrolled hypertension was complicated by the development of lactic acidosis, without hypotension. (annals.org)
- The authors had observed that on intraoperative discontinuation of sodium nitroprusside being administered to induce hypotension, mean arterial pressure increased to above the pre-hypotension level. (ovid.com)
- During sodium nitroprusside-induced hypotension, mean arterial pressure decreased to 49 ± 2 torr and plasma renin activity increased to 15.2 ± 0.2 ng/ml/hr. (ovid.com)
- As the half-life of plasma renin is 15 min, the data suggest that the persistently increased plasma renin activity is probably responsible for the increase of arterial pressure following sodium nitroprusside-induced hypotension. (ovid.com)
- Cyanide toxicity following nitroprusside induced hypotension. (semanticscholar.org)
- A sudden death associated with the use of sodium nitroprusside for induction of hypotension during anaesthesia. (semanticscholar.org)
- Common side effects of nitroprusside include excessively low blood pressure (hypotension), cyanide toxicity, and injection site irritation. (rxwiki.com)
- Controlled hypotension in adults undergoing choroidal melanoma resection: comparison between the efficacy of nitroprusside and magnesium sulphate. (semanticscholar.org)
- BACKGROUND AND OBJECTIVE To determine whether magnesium sulphate could induce controlled hypotension, reduce choroidal blood flow, provide a 'dry' operative field and could be compared with sodium nitroprusside in the recently raised issue of the use of hypotensive anaesthesia in eye surgery, i.e. for choroidal tumour surgery as the choroid is the most fragile and vascular structure in the eye. (semanticscholar.org)
- RESULTS Controlled hypotension was achieved at the target systolic pressure of 80 mmHg within 107 +/- 16 and 69 +/- 4.4 s for magnesium sulphate and sodium nitroprusside, respectively. (semanticscholar.org)
- Sodium nitroprusside is commonly used for the induction of hypotension during neurosurgical procedures. (thejns.org)
- Cyanide accumulation is more likely in patients who are receiving nitroprusside at rates of 2 mcg/kg/min or more, but has been reported in rare cases after lesser dosages within 0.5 to 3.0 hours of infusion time. (drugs.com)
- Infusion of sodium nitroprusside should therefore be started at a very low rate (0.3 mcg/kg/min), with upward titration every few minutes until the desired effect is achieved or the maximum recommended infusion rate (10 mcg/kg/min) has been reached. (rxlist.com)
- In an open-label study, we compared the efficacy and safety of intravenous infusion of fenoldopam mesylate with that of sodium nitroprusside in patients with severe hypertension or in hypertensive crisis. (ahajournals.org)
- Both antihypertensive medications were infused at a maximal dose increment of 0.2 microgram/kg/min (fenoldopam) and 1 microgram/kg/min (nitroprusside), with a maximal infusion rate of 1.5 micrograms/kg/min fenoldopam mesylate or 8 micrograms/kg/min sodium nitroprusside. (ahajournals.org)
- Nitroprusside is injected into a vein through an infusion pump. (everydayhealth.com)
- The acute effects of nitroprusside infusion and intravenous hydralazine on renal hemodynamics and function were evaluated in nine male patients with severe, low cardiac output, congestive heart failure (CHF). (ahajournals.org)
- Gao, Y and Er, MJ (2004) Adaptive fuzzy neural control of mean arterial pressure through sodium nitroprusside infusion In: 42nd IEEE Conference on Decision and Control, 2003-12-09 - 2003-12-12, Maui, HI. (surrey.ac.uk)
- We tested the hypothesis that intracoronary infusion of the nitric oxide donor nitroprusside would increase the efficiency of adenovirus vector-mediated gene transfer to the heart. (pubfacts.com)
- Intracoronary delivery of an adenovirus encoding murine adenylyl cyclase type VI (Ad.AC(VI)) was performed in adult pigs with and without simultaneous intracoronary infusion of nitroprusside. (pubfacts.com)
- Addition of nitroprusside during intracoronary infusion of Ad.AC(VI) was associated with a 4-fold increase in cAMP-generating capacity in the left ventricle. (pubfacts.com)
- Intracoronary nitroprusside produced mild dose-dependent changes in blood pressure and heart rate during infusion. (pubfacts.com)
- Intracoronary nitroprusside infusion is a safe and effective means to increase the extent of cardiac gene transfer with intracoronary delivery of adenovirus vectors. (pubfacts.com)
- METHODS Forty adult patients undergoing choroidal melanoma resection and anaesthetized with 2.5 mg kg(-1) propofol, followed by a constant infusion of 120 microg kg(-1) min(-1), and remifentanil 1 microg kg(-1), followed by a continuous infusion of 0.25 microg kg(-1) min(-1), were randomly assigned to two groups to receive either magnesium sulphate or sodium nitroprusside. (semanticscholar.org)
- Therefore, the aim is to review basic and clinical research findings from studies evaluating the effects of cannabidiol (CBD), an inhibitor of the reuptake and metabolism of anandamide and several other effects on nervous system, and sodium nitroprusside, a nitric oxide donor, on the prevention and treatment of psychosis. (greenmedinfo.com)
- Sodium nitroprusside is a nitric oxide donor that could potentially alter MMP activity via vasodilation in vivo, but can also produce peroxynitrite, which activates MMPs by combining with superoxide. (dovepress.com)
- Alternatively, as the drug chosen for pressure control, sodium nitroprusside, serves as a nitric oxide donor, the relative balance between nitric oxide-mediated vasodilation and Ang II-induced vasoconstriction could have regional differences. (diva-portal.org)
- The detection of toxic levels of thiocyanate in two patients treated with nitroprusside, however, shows that fenoldopam might be preferable for the control of a hypertensive crisis or severe hypertension in patients with decreased renal function. (ahajournals.org)
- Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). (everydayhealth.com)
- Sodium nitroprusside should not be used for compensatory hypertension (e.g. due to an anteriovenous stent or coarctation of the aorta). (orange.com)
- Nitroprusside sodium is commonly used for treating congestive heart failure and life-threatening high blood pressure (hypertension). (hellodoktor.com)
- Hypertension should be managed with a short-acting, easily titrated agent (eg, nitroprusside) if it is not controlled with benzodiazepine-induced sedation. (medscape.com)
- Renal activation of the reninangiotensin system and catecholamine release can occur with a decrease in arterial blood pressure, which can cause rebound hypertension with discontinuation of sodium nitroprusside . (anesthesiageneral.com)
- Nitroprusside is an injectable prescription medication used to treat hypertension and congestive heart failure. (rxwiki.com)
- He gradually recovered following the operation, but needed continued administration of sodium nitroprusside for control of hypertension. (thejns.org)
- Sodium nitroprusside is also indicated for the treatment of acute congestive heart failure . (rxlist.com)
- Renal effects of nitroprusside and hydralazine in patients with congestive heart failure. (ahajournals.org)
- In the us, nipride (nitroprusside) is indicated for lowering blood pressure in cases of hypertensive crisis, for acute congestive heart failure , & for lowering blood pressure to decrease bleeding. (healthtap.com)
- Nitroprusside is a prescription medication used to treat high blood pressure (hypertention) and congestive heart failure. (rxwiki.com)
- 50 mg Fliptop Vial - Each 2 mL vial contains the equivalent of 50 mg sodium nitroprusside dihydrate in sterile water for injection. (rxlist.com)
- Sodium nitroprusside dihydrate reagent used for chromatographic detection of peptides containing cystine. (thomassci.com)
- Fluka Sodium nitroprusside dihydrate puriss. (thomassci.com)
- Sodium nitroprusside dihydrate [disodium pentacyanonitrosyl ferrate(III) dihydrate] GR for analysis ACS,Reag. (merckmillipore.com)
- Johnson CC. The actions and toxicity of sodium nitroprusside. (jamanetwork.com)
- The potential toxicity of sodium nitroprusside, measures to prevent toxicity, and therapeutic steps are discussed. (thejns.org)
- In the second part of the study, sodium nitroprusside (SNP) was infused at doses titrated to keep mean arterial pressure constant, in spite of concurrent Ang II administration. (diva-portal.org)
- Thirty minutes after discontinuation of sodium nitroprusside administration, mean arterial pressure increased to 112 ± 2 torr, which was not only higher than the prehypotension level, but also significantly higher than that recorded in the awake state. (ovid.com)
- Some side effects of nitroprusside may occur that usually do not need medical attention. (drugs.com)
- Sodium Nitroprusside Injection is supplied in amber-colored, 50 mg/2 mL Single Dose Vials (NDC 70436-028-80). (druginserts.com)
- To protect Sodium Nitroprusside Injection from light, it should be stored in its carton until it is used. (druginserts.com)
- Dietary sodium intake modulates vasodilation mediated by nitroprusside but not by methacholine in the human forearm. (biomedsearch.com)
- We conclude that under conditions of salt loading, vasodilation in response to sodium nitroprusside was enhanced, whereas the response to methacholine was not affected, suggesting a differential effect of sodium intake on endothelium-dependent and endothelium-independent responses after the administration of methacholine and sodium nitroprusside, respectively. (biomedsearch.com)
- Nitroprusside causes peripheral vasodilation by acting directly on venous and arteriolar smooth muscle, thus reducing peripheral resistance. (medscape.com)
- Mice were maintained in a normothermic state or cooled to 25 degrees C. The aorta or both the pulmonary artery and aorta were clamped while a needle was advanced into the left ventricular cavity to deliver adenovirus vectors encoding enhanced green fluorescent protein (EGFP) or murine adenylyl cyclase type VI (AC(VI)) with saline, sodium nitroprusside, acetylcholine, or serotonin. (pubfacts.com)
- Forearm blood flow was measured by venous occlusion plethysmography during dose-response studies of acetylcholine (ACh) and sodium nitroprusside (SNP) infused into the brachial artery. (diabetesjournals.org)
- nitroprusside is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
- An allergy to nitroprusside could be as mild as a mild rash or as severe as difficulty breathing as well as other adverse effects. (healthtap.com)
- Furthermore, continued administration of nitroprusside (after the initial relief of dyspnea) generally requires the placement of an arterial line and oftentimes, a pulmonary flow-directed catheter (Swan-Ganz) for optimal safe dosing. (endocrinologyadvisor.com)
- Efficacy and safety of oral propranolol premedication to reduce reflex tachycardia during hypotensive anesthesia with sodium nitroprusside in orthognathic surgery: a double-blind randomized clinical trial. (druglib.com)
- PURPOSE: The present study sought to determine whether premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside could reduce reflex tachycardia, the amount of sodium nitroprusside used, and blood loss during hypotensive anesthesia for orthognathic surgery. (druglib.com)
- PATIENTS AND METHODS: A total of 60 patients undergoing bimaxillary surgery were studied in a prospective, randomized, and double-blind study of oral propranolol 10 mg or placebo as premedication before hypotensive anesthesia with sodium nitroprusside. (druglib.com)
- CONCLUSION: Premedication with oral propranolol 10 mg before hypotensive anesthesia with sodium nitroprusside is safe and effective to reduce reflex tachycardia and the amount of sodium nitroprusside used. (druglib.com)
- What number of milligrams of nipride (nitroprusside) per hour is the patient receiving? (healthtap.com)
- Nipride (nitroprusside) is a drug we restrict to critical care administration in most cases. (healthtap.com)
- My physician prescribed nipride (nitroprusside). (healthtap.com)
- Nipride is the trade name for nitroprusside which is a medication given only in an ICU with close observation. (healthtap.com)
- Nipride (nitroprusside) is an IV-only nitrate medicine for acute hypertensive urgency. (healthtap.com)
- What is nipride (nitroprusside) drip? (healthtap.com)
- What is nipride (nitroprusside) used for? (healthtap.com)
- His physician prescribed nipride (nitroprusside) 3 mcg/kg/minute, iv. (healthtap.com)
- 2020. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51549/all/nitroprusside. (unboundmedicine.com)
- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
- THURSDAY, Aug. 10, 2017 (HealthDay News) -- Increases in the price of nitroprusside and isoproterenol correlated with reductions in their use, according to a letter to the editor published online Aug. 9 in the New England Journal of Medicine . (doctorslounge.com)
- Umesh N. Khot, M.D., from the Cleveland Clinic, and colleagues examined the impact of price increases on physician prescribing for nitroprusside or isoproterenol using data from 47 hospitals in the Vizient (formerly University HealthSystem Consortium) database. (doctorslounge.com)
- The researchers found that the absolute number of patients treated with nitroprusside or isoproterenol decreased by 53 and 35 percent, respectively, from 2012 to 2015. (doctorslounge.com)
- Effects of sodium nitroprusside, isosorbide dinitrate, isoproterenol, phentolamine and prazosin on hepatic venous responses to sympathetic nerve stimulation in the cat. (aspetjournals.org)
- Differential effects of diltiazem and nitroprusside on left ventricular function in experimental chronic volume overload. (ahajournals.org)
- Nitroprusside reduces left ventricular diastolic pressure, left atrial pressure, pulmonary wedge pressure (pulmonary artery occlusive pressure), right atrial pressure, and pulmonary and systemic vascular resistance. (endocrinologyadvisor.com)
- After initial dosing to offer relief for severe dyspnea, continued nitroprusside administration is most effective and safest with hemodynamic monitoring with an indwelling arterial line and oftentimes a pulmonary artery flow-directed catheter. (endocrinologyadvisor.com)
- Hemodynamic variables, the amount of sodium nitroprusside used, and blood loss were statistically analyzed. (druglib.com)
- Sodium nitroprusside has potent vasodilating effects in arterioles and venules (arterioles more than venules, but this selectivity is much less marked than that of nitroglycerin, which acts preferentially at venous smooth muscle) as a result of its breakdown to nitric oxide (NO). Sodium nitroprusside breaks down in circulation to release nitric oxide (NO). It does this by binding to oxyhaemoglobin to release cyanide, methaemoglobin and nitric oxide. (wikipedia.org)
- Finally, alternate agents to sodium nitroprusside include other vasodilators such as nitroglycerin and hydralazine. (anesthesiageneral.com)
- What should I Know Regarding Pregnancy, Nursing and Administering Sodium Nitroprusside Vial to Children or the Elderly? (webmd.com)
- Medications with generic name beginning with the letter 'S' (Sodium Nitroprusside). (druginserts.com)
- Sodium nitroprusside is indicated for the immediate reduction of blood pressure of adult and pediatric patients in hypertensive crises. (rxlist.com)
- Sodium nitroprusside has gained acceptance in the treatment of hypertensive emergencies and low cardiac-output syndromes associated with high systemic vascular resistance. (annals.org)
- The aim of this study was to elucidate the vasodilating mechanism of sodium nitroprusside (SNP). (aspetjournals.org)
- Hemoglobin is a biologically active substance capable of catalyzing the release of cyanide from nitroprusside. (drugs.com)
- Hemolysis occurs as a consequence of cell injury during CPB which may make a greater amount of hemoglobin available to react with nitroprusside and this ultimately increases the risk of cyanide toxicity. (drugs.com)
- After gaining an electron from the iron moiety of hemoglobin, the sodium nitroprusside produces an unstable radical and methemoglobin. (anesthesiageneral.com)
- Nitroprusside is a sodium or potassium salt of a molecule that includes Fe++, cyanide and nitric acid. (endocrinologyadvisor.com)
- Toxicity from sodium nitroprusside is due to the cyanide groups released from metabolism of the nitroprusside molecule, resulting in cyanide toxicity . (anesthesiageneral.com)
- Prevention of cyanide toxicity can be achieved by limiting the dose of sodium nitroprusside to less than 8.0 micrograms/kg/min over 1 to 3 hours. (anesthesiageneral.com)
- Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine. (biomedsearch.com)
- Lockwood A, Patka J, Rabinovich M, Wyatt K, Abraham P. Sodium nitroprusside-associated cyanide toxicity in adult patients-fact or fiction? (jamanetwork.com)
- Their goal was to see if there was a decreased risk of POAF when patients were given sodium nitroprusside. (gregjoneslawblog.com)
- What the researchers found was that of the patients who were analyzed and given sodium nitroprusside, 25.4 percent of them developed POAF vs. 27.9 percent of the patients in the control group. (gregjoneslawblog.com)
- Sodium nitroprusside is more active on veins than on arteries. (drugbank.ca)
- Nitroprusside inhibited L-type calcium currents, transient outward currents and transient inward current, but increased delayed rectified potassium currents. (biomedcentral.com)
- We then contrasted least squares linear regression slopes derived from the depressor (nitroprusside) and pressor (phenylephrine) phases with 1) slopes derived from spontaneous fluctuations of systolic arterial pressures and R-R intervals, and 2) baroreflex gain derived from cross-spectral analyses of systolic pressures and R-R intervals. (elsevier.com)
- Subjects with post-traumatic stress disorder (PTSD) will be evaluated using microneurography, static handgrip exercise, cold pressor test, combat virtual reality video clip, and baroreflex sensitivity using sodium nitroprusside and phenylephrine. (clinicaltrials.gov)
- Treatment of cyanide toxicity begins with discontinuation of sodium nitroprusside administration. (anesthesiageneral.com)
- Before initiating nitroprusside therapy, administer a beta blocker to counteract the physiologic response of reflex tachycardia that occurs when nitroprusside is used alone. (medscape.com)
- FDA pregnancy category C. It is not known whether nitroprusside will harm an unborn baby. (everydayhealth.com)
- There are no adequate studies in women for determining risk when using this Nitroprusside Sodium during pregnancy or while breastfeeding. (hellodoktor.com)
- This Nitroprusside Sodium is pregnancy risk category C, according to the US Food and Drug Administration (FDA). (hellodoktor.com)
- Nitroprusside increases gene transfer associated with intracoronary delivery of adenovirus. (pubfacts.com)
- The unstable sodium nitroprusside radical produces five cyanide ions, which can have one of three fates. (anesthesiageneral.com)