A potent vasodilator agent that increases peripheral blood flow.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
The sexual union of a male and a female, a term used for human only.
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Drugs used to cause dilation of the blood vessels.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)
Apparatus, devices, or supplies intended for one-time or temporary use.
A prolonged painful erection that may lasts hours and is not associated with sexual activity. It is seen in patients with SICKLE CELL ANEMIA, advanced malignancy, spinal trauma; and certain drug treatments.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.
Introduction of substances into the body using a needle and syringe.
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART.
The inferior part of the lower extremity between the KNEE and the ANKLE.
The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.
A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty. (APA, DSM-IV, 1994)
An erectile structure homologous with the penis, situated beneath the anterior labial commissure, partially hidden between the anterior ends of the labia minora.
The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES.
Sleep disorders characterized by impaired arousal from the deeper stages of sleep (generally stage III or IV sleep).
Literary or artistic items having an erotic theme. It refers especially to books treating sexual love in a sensuous or voluptuous manner. (Webster, 3d ed)
The use of humans as investigational subjects.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The interactions between physician and patient.
Those individuals engaged in research.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
An absence of warmth or heat or a temperature notably below an accustomed norm.
A characteristic symptom complex.
Bones that make up the SKELETON of the TOES, consisting of two for the great toe, and three for each of the other toes.
Bones that make up the SKELETON of the FINGERS, consisting of two for the THUMB, and three for each of the other fingers.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Any one of five terminal digits of the vertebrate FOOT.
The bones of the upper and lower ARM. They include the CLAVICLE and SCAPULA.

Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro. (1/875)

1. The thienopyridine clopidogrel is a specific inhibitor of ADP-induced platelet aggregation ex vivo. No direct effects of clopidogrel (< or = 100 microM) on platelet aggregation in vitro have been described so far. 2. Possible in vitro antiaggregatory effects (turbidimetry) of clopidogrel were studied in human platelet-rich plasma and in washed platelets. 3. Incubation of platelet-rich plasma with clopidogrel (< or = 100 microM) for up to 8 h did not result in any inhibition of ADP (6 microM)-induced platelet aggregation. 4. Incubation of washed platelets with clopidogrel resulted in a time- (maximum effects after 30 min) and concentration-dependent (IC50 1.9+/-0.3 microM) inhibition of ADP (6 microM)-induced platelet aggregation. Clopidogrel (30 microM) did not inhibit collagen (2.5 microg ml(-1))-, U46619 (1 microM)- or thrombin (0.1 u ml(-1))-induced platelet aggregation. The inhibition of ADP-induced aggregation by clopidogrel (30 microM) was insurmountable indicating a non-equilibrium antagonism of ADP actions. The R enantiomer SR 25989 C (30 microM) was significantly less active than clopidogrel (30 microM) in inhibiting platelet aggregation (32+/-5% vs 70+/-1% inhibition, P < 0.05, n = 5). 5. In washed platelets, clopidogrel (< or = 30 microM) did not significantly reverse the inhibition of prostaglandin E1 (1 microM)-induced platelet cyclic AMP formation by ADP (6 microM). 6. The antiaggregatory effects of clopidogrel were unchanged when the compound was removed from the platelet suspension. However, platelet inhibition by clopidogrel was completely abolished when albumin (350 mg ml(-1)) was present in the test buffer. 7. It is concluded that clopidogrel specifically inhibits ADP-induced aggregation of washed platelets in vitro without hepatic bioactivation. Inhibition of ADP-induced platelet aggregation by clopidogrel in vitro occurs in the absence of measurable effects on the reversal of PGE1-stimulated cyclic AMP by ADP.  (+info)

Oxytocin-induced Ca2+ responses in human myometrial cells. (2/875)

Complex spatiotemporal changes in intracellular Ca2+ were monitored in an immortalized human myometrial cell line (PHM1-41) and first-passage human myometrial cells after oxytocin stimulation (1. 0-1000 nM). Laser cytometry revealed intracellular Ca2+ oscillations in both culture systems starting at 1.0 nM, which were followed by repetitive Ca2+ transients by 10-15 min that lasted for at least 90 min. The amplitude of the initial Ca2+ spike was dose dependent, while the frequency of Ca2+ oscillations identified by Fast Fourier Transform (FFT) tended to increase with dose. Removal of oxytocin resulted in termination of oscillations. Analysis of the sources of the Ca2+ involved in oscillations indicated that the major contribution to oscillation frequencies of +info)

Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta. (3/875)

A number of cytokines and their receptors are abundantly expressed at the materno-fetal interface and are thought to have a function in the regulation of placentation. Granulocyte-colony stimulating factor (G-CSF) is expressed by stromal cells in both placental tissue and maternal decidua throughout placentation. In this study, we examined the expression of placental G-CSF receptor (G-CSFR) mRNA and protein throughout gestation by ribonuclease protection assays, Western blotting, and immunohistochemistry. The major placental form of G-CSFR mRNA, corresponding to a membrane-bound form of the protein, was present in first-trimester placental tissues; levels decreased in second- and were highest in third-trimester placental tissues. Two placental G-CSFR molecules, 120 kDa and 150 kDa, were detected in first- and third-, but not second-, trimester tissues. The level of the 150-kDa G-CSFR was greater in the third- than in first-trimester samples. These differences were irrespective of whether or not the patients had received prostaglandin E1 analogues, prostaglandin E1 analogues and oxytocin, oxytocin alone, or mifepristone before labor. We demonstrated by immunohistochemistry that interstitial cytotrophoblast in first- and second-trimester decidual tissue and cytotrophoblast in term fetal membranes express G-CSFR. These data demonstrate that the expression of specific forms of placental G-CSFR is strictly cell type- and developmental stage-specific, and they suggest that G-CSFR may be important in decidual invasion of cytotrophoblast and in trophoblast function during placentation.  (+info)

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (4/875)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. (5/875)

1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat. 2. One hundred and sixty-seven, male Wistar rats were anaesthetized (thiopentone, 120 mg kg(-1) i.p.), ventilated (8-10 ml kg(-1), 70 strokes min(-1), inspiratory oxygen concentration: 30%; PEEP: 1-2 mmHg) and subjected to occlusion of the left anterior descending coronary artery (LAD, for 7.5, 15, 25, 35, 45 or 60 min) followed by reperfusion (2 h). Infarct size was determined by staining of viable myocardium with a tetrazolium stain (NBT), histological evaluation by light and electron microscopy and determination of the plasma levels of cardiac troponin T. 3. M&B 28767 (0.5 microg kg(-1) min(-1), i.v., n=7) or GR 63799X (3 microg kg(-1) min(-1), i.v., n=7) caused significant reductions in infarct size from 60+/-3% (25 min ischaemia and 2 h reperfusion; saline-control, n=8) to 39+/-6 and 38+/-4% of the area at risk, without causing a significant fall in blood pressure. Pretreatment of rats with 5-hydroxydecanoate (5-HD), an inhibitor of ATP-sensitive potassium channels, attenuated the cardioprotective effects of both EP3-receptor agonists. The reduction in infarct size afforded by M&B 28767 was also abolished by glibenclamide and the protein kinase C (PKC) inhibitors staurosporine and chelerythrine. 4. Thus, M&B 28767 and GR 63799X reduce myocardial infarct size in the rat by a mechanism(s) which involves the activation of PKC and the opening of ATP-sensitive potassium channels.  (+info)

Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm. (6/875)

We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere (Lipo-PGE1) in relation with transcranial Doppler parameters such as mean flow velocity (MFV) and pulsatile index (PI) of the proximal segment of the middle cerebral artery. Eighty patients with subarachnoid hemorrhage (SAH) were included in this study. In the case of angiographic vasospasm, papaverine at 7 mg/min with total dose below 300 mg per artery and 10-20 micrograms of Lipo-PGE1 were injected in the supraclinoid portion of the internal carotid artery. Vasospasm was improved in 24 patients (63%), however, it was unchanged in 14 patients (37%). The former patients had more favorable outcomes than the latter patients (p < 0.005). After intracarotid injection therapy, the correlation between MFV and PI was classified into three types: type 1, both MFV and PI decreased; type 2, MFV decreased but PI increased; and type 3, both MFV and PI fluctuated. The Glasgow Outcome Scale 3 months after SAH was as follows: type 1 (n = 15), good in 14 (93%) and moderate disability in one (7%); type 2 (n = 9), good in eight (89%) and vegetative state in one (11%); and type 3 (n = 14), moderate disability in five (36%), severe disability in seven (50%), and death in two (14%). Chi-square analysis showed significant differences between type 1 and type 3 (p < 0.005), and type 2 and type 3 (p < 0.005). In conclusion, intracarotid papaverine combined with Lipo-PGE1 was effective for vasospasm but type 3 patients require a different treatment protocol.  (+info)

Platelet-stimulated thrombin and PDGF are normalized by insulin and Ca2+ channel blockers. (7/875)

Coronary artery disease is accelerated in chronic spinal cord injury (SCI). Because prostacyclin (PGI2) may retard atherogenesis through its inhibitory effects on platelet function, the role of PGI2 on SCI platelets was determined. The SCI platelets were neither hypersensitive to aggregating agonists nor resistant to the inhibitory effect of PGI2, but PGI2 failed to inhibit platelet-stimulated thrombin generation and the release of platelet-derived growth factor (PDGF) in SCI. Because thrombin and PDGF are atherogenic mitogens, the generation of these mitogens was investigated. Both the release of PDGF and thrombin generation in SCI platelets were higher when compared with control (n = 12). Treatment of non-SCI platelets with 100 nM PGE1 (a stable probe of PGI2) inhibited the release of the mitogens by 90% (P < 0.001), with no effect on SCI platelets. Scatchard analysis of prostaglandin E1 (PGE1) binding showed a 70% decrease of PGI2 receptors on the SCI platelet surface. Treatment of SCI platelets with insulin or Ca2+ channel blockers restored the PGI2-receptor number and "normalized" the inhibition of PDGF release and thrombin generation by PGI2.  (+info)

Seminal plasma components stimulate interleukin-8 and interleukin-10 release. (8/875)

Human seminal plasma has potent anti-inflammatory properties which are thought to confer a survival advantage to the spermatozoa within the hostile female genital tract. In contrast, a profound pro-inflammatory leukocytosis has been observed post-coitus in animals and humans. Whether components of seminal plasma are involved in initiating this leukocytic reaction is not known. This study investigated the effect of human seminal plasma, a seminal plasma fraction and its principal constituent prostaglandins, prostaglandin E2 (PGE2) and 19-hydroxy PGE, on the release of the pro-inflammatory neutrophil chemotactic factor interleukin-8 (IL-8) and the anti-inflammatory cytokines interleukin-10 (IL-10) and secretory leukocyte protease inhibitor (SLPI). The tissues studied were non-pregnant cervical explants, peripheral blood and the monocyte cell line U937. Seminal plasma fraction (SPF) significantly (P < 0.05) stimulated release of IL-8 and inhibited release of SLPI from non-pregnant cervical explants. SPF, PGE2 and 19-hydroxy PGE significantly (P< 0.005) stimulated IL-8 release from peripheral blood and U937 cells. 19-hydroxy PGE was significantly (P< 0.005) more effective than PGE2 in stimulating IL-8 release. Seminal plasma, SPF and PGE2 significantly (P < 0.05) stimulated IL-10 release from U937 cells. 19-hydroxy PGE stimulated IL-10 release from U937 cells but this failed to reach significance. Release of IL-10 by cervical explants and SLPI by peripheral blood and U937 cells were below the detection limit of the assays employed. We suggest that the anti- and pro-inflammatory immune responses which seminal plasma induces might act in combination initially to promote sperm survival and then to facilitate their removal from the female genital tract.  (+info)

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Female sexual arousal disorder (FSAD) is a frequent finding in women in middle age and more prevalent in post-menopausal women. Topical alprostadil is currently under development for the treatment of FSAD. The purpose of this research is to determine if this formula of alprostadil is safe and effective in women with FSAD. We will be comparing alprostadil to placebo. Each participant will be treated for 1 month with active alprostadil and 1 month with placebo without knowing which they are using. This way, the investigators can compare the effects of alprostadil to the effects of an inactive topical gel.. Post-menopausal women with FSAD will be recruited. The women interested in participating in the study will first meet with investigators and answer questions to make sure they are eligible for the study and fit the diagnosis of FSAD.. Once enrolled, subjects will fill out questionnaires about their medical history, social history, and psychosocial history. They will also undergo medical ...
Buy Alprostadil Online! Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition.
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Using too much alprostadil can be very dangerous.. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.. The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).. Your first dose of this medicine will be given in your doctors office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an ...
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Buy Alprostadil Online! Alprostadil, also known as Prostaglandin E1, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out.
Buy Alprostadil Online! Alprostadil, also known as Prostaglandin E1, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out.
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Buy Alprostadil Online! Alprostadil is a medicine that men take for ED (erectile dysfunction). This drug makes the blood vessels expand. Its only available by prescription.
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Alprostadil is injected into the side of penis with a very fine needle. Its of great value to have the first shot in the doctors office before doing this on your own. Self-injection lessons should be given in your doctors office by an experienced professional. The success rate for getting an erection firm enough to have sex is as high as 85% with this treatment. Many men who do not respond to oral PDE5 inhibitors can be rescued with ICI.. ICI Alprostadil may be used as a mixture with two other drugs to treat ED. This combination therapy called bimix or trimix is stronger than alprostadil alone and has become standard treatment for ED. Only the Alprostadil ingredient is FDA approved for ED. The amount of each drug used can be changed based on the severity of your ED, by an experienced health professional. You will be trained by your health professional on how to inject, how much to inject and how to safely raise the drugs dosage if necessary.. ICI therapy often produces a reliable ...
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10 Intracorporeal Injections Montorsi. and colleagues were the first to show human data supporting penile rehabilitation in their published randomized trial comparing men using intracavernosal injections of alprostadil three times weekly for 12 weeks after radical prostatectomy with those using no treatment.34 At the conclusion of the study, they found 67% of the patients in the injection therapy arm had natural Inhibitors,research,lifescience,medical erections sufficient for intercourse at 6 months, as compared with 20% in the control arm of the study. Doppler penile ultrasound on these patients at the conclusion of the study showed that patients who failed to recover erectile function had venous leak. Mulhall and colleagues performed a nonrandomized study in patients who were nonresponders to sildenafil.37 These patients were switched to intracorporeal. injection (ICI) therapy with alprostadil (3 times/week). These patients had to be followed for a minimum of 18 months and had to complete at ...
Choose a different place of injection each time you use the medicine to prevent skin problems. This includes switching the place of injection from the right side of the penis for one injection to the left side for the next injection. After a single-use injection is mixed, the medicine must be used immediately. Throw away any unused mixture in the syringe. It cannot be stored for a later injection. Do not reuse or share your needles or cartridges. Never use a bent needle and never try to straighten a bent needle prior to injecting. How to throw away the syringes and bottles safely:. Dispose of your materials properly. Caverject® comes in a plastic case that can be permanently locked with the red locking device that is included with the packaging. When the case label is removed, you can see a hole in the center of the case. The red locking device can be inserted and, by firmly pressing it down with your thumb, you will permanently lock the case. The locked case is safe to be thrown away.. This ...
Patients not responding to oral therapy may be offered ICIs, and prostaglandin E1 (alprostadil) is the most common drug; different formulations include Bimix (papaverine and phentolamine) and Trimix (alprostadil, papaverine and phentolamine).
MUSE: Alprostadil belongs to a family of medications known as prostaglandins. Prostaglandins like alprostadil cause increased blood flow to certain areas of the body by causing the blood vessels in the area to widen. This medication is used to treat erectile dysfunction by causing increased blood flow to the penis in particular.
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A bicyclic fatty acid derived from prostaglandin E1 and a chloride channel activator with laxative activity. Upon intake, lubiprostone specifically binds to and activates the type 2 chloride channel (ClC-2) in the apical membrane of the gastrointestinal epithelium. This produces an efflux of chloride ions, thereby drawing water into the gastrointestinal lumen. The resulting increased amounts of intestinal fluid soften the stool, increase motility, and improve bowel movements.
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Dr is recommending Tri mix penile injections after 13 + years using oral ED meds, that approach no longer working. Good blood flow testing says, great nocturnal erections, can get erection with Viagra, but cant maintain for 1-5 min. Dr says Tri mix should work. Any body here willing to share experience pros cons etc? On TRT for 8 months no change on ED issue (was not the reason for starting TRT), Thanks
Age: 54 at surgery (DOB 1955). Married: Yes (31 years). Gleason: 3+3. Surgery: Davinci on 06-25-2009, catheter out July 6, 2009. Continancy: Only some Stress wetness in first months. No pads since. PSA (post): Below .10 since surgery. Erection: 1 month : Pump was effective for intercourse but not satisfying. 3 months: Pump with Viagra, Levitra, Cialis (LVC) was better but not much. 6 months: Alprostadil (0.6cc) with pump with inconsistent results. 9 months: Alprostadil (1.0cc)with pump and LVC was better but inconsistent results. 12 months: TRiMix(0.4cc)/Pump/LVC and WOW Return of the Light Saber, life is good. 100% erection for over 2 hours, 85% for another hour or so. FUN FUN FUN. ...
Check with your doctor immediately if any of the following side effects occur: Rare . Check with your doctor immediately if any of the following side effects occur while taking alprostadil: Some side effects of alprostadil may occur that usually do not need medical attention. In addition to the adverse reactions observed for CAVERJECT, the following adverse reactions have been drugs a-z list Common side effects of Caverject include: Tell your doctor if you have unlikely but serious side effects of Caverject including: The dose of Caverject is individualized for each patient under supervision of a physician. Side effects, images, and drug details for Caverject. Price a Medication. Facebook Twitter LinkedIn. erection continuing longer than 6 hours with severe and continuing pain of the penis. Filter group. Schwarz Pharma, Mequon, WI.  have sickle cell anaemia (a blood disease), leukaemia (cancer of the blood), multiple myeloma (bone cancer) or any other problem which increases the
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil Abstract.
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Sucampo Pharmaceuticals, Inc. is a science-driven pharmaceutical company, based in Bethesda, Md., focusing on gastrointestinal and specialty diseases. Sucampo has concentrated on developing and commercializing drugs from its proprietary prostone technology platform, which was created by Ryuji Ueno, M.D., Ph.D., Co-Founder, Executive Chair, Chief Operating Officer and Chief Scientific Officer of the company. Prostones are a new class of functional fatty acid with a variety of physiological and pharmacological activities. The first commercial prostone product, RESCULA®, was launched in Japan, and later in more than 40 countries, for the treatment of glaucoma. AMITIZA is Dr. Uenos second prostone product to be marketed in the United States, and the first selective chloride channel activator for therapeutic use. To learn more about the company and its products, visit http://www.sucampo.com/ ...
Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth.
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Alprostadil (Caverject) 10-20 mg/mL; inject into the dorsolateral aspect of proximal third of the penis. Do not exceed 60 mg dose. Do not use more than 3 times a week or more than once in 24 hours. Patient to notify physician if erection lasts , 6 hours for immediate attention ...
Learn about the potential side effects of Caverject Impulse (alprostadil). Includes common and rare side effects information for consumers and healthcare professionals.
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alprostadil gel/cream If Rodriguez indicates that he will appeal his looming suspension to stay on the field and protect his contract, commissioner Bud Selig is prepared to invoke his rarely used right to suspend a player to preserve the integrity of the game â  a power embodied in Article XI, Section A1b of the gameâ  s collective bargaining agreement. Doing so would effectively bypass the joint drug agreement between MLB and the union. Such a suspension would be effective immediately ...
ADVANZ PHARMA Corp. Limited Announces Definitive Agreement to Acquire The Rights To A Portfolio Of Alprostadil Products From UCB S.A. For Approximately $84 ...
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Alprostadil: Find the most comprehensive real-world treatment information on Alprostadil at PatientsLikeMe. 4 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), epilepsy, amyotrophic lateral sclerosis, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, asthma, bipolar II disorder, attention deficit/hyperactivity disorder, social anxiety disorder, high cholesterol (hypercholesterolemia), idiopathic pulmonary fibrosis, irritable bowel syndrome, psoriasis, gastroesophageal reflux disease or bipolar I disorder currently take Alprostadil.
NEXMED TO DISCUSS P2/3 PROTOCOL FOR NEXACT® -BASED ALPROSTADIL TREATMENT FOR RAYNAUDS SYNDROME WITH THE FDA San Diego--(BUSINESS WIRE)-- NexMed, Inc. (Nasdaq: NEXM), a specialty CRO with a
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An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
Doctors determine the proper dose of Caverject. It is essential that physicians or nurses teach proper use.. FDA approved Edex, a slightly different formulation of alprostadil, in 1997. It is less expensive than Caverject and is injected with a smaller needle. Users inject it ten minutes before sex; erections can last more than one hour.. Sometime this year, FDA will evaluate another injectable medication, Invicorp. It consists of the protein VIP and phentolamine, which help relax smooth-muscle tissue. It may be more effective than alprostadil and is not expected to cause the pain associated with Caverject and Edex.. * Transurethral therapy. A relatively new product approved in 1997, alprostadil is administered by means of a small applicator that delivers a soft, tiny, medicated pellet to the urethra [the opening at the end of the penis]. The urethra absorbs the drug and distributes it to the surrounding erectile tissues. This causes blood vessels to relax and allows the penis to fill with ...
Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals North America, Inc., announced today that AMITIZA (lubiprostone), 24-mcg soft-gel capsules, approved by the U.S. Food and Drug Administration (FDA) in January 2006, is now available by prescription in pharmacies across the United States for the treatment of chronic idiopathic constipation in adults.
Erectile Dysfunction News Some males with erectile dysfunction , or ED, discover they will return to an energetic intercourse life by treating an underlying condition, equivalent to high blood pressure , or with counseling and life-style modifications. Porst H, van Ahlen H, Block T et al: Intracavernous self-injection of prostaglandin E1 in the remedy of erectile dysfunction. The period of time required for sildenafil to start working can depend upon a number of factors, from the precise response its a must to the drug to the quantity you have eaten before swallowing the tablet. Therapy of male impotence or erectile dysfunction will depend upon the cause of erectile dysfunction. Yiou R, Cunin P, de la Taille A et al: Sexual rehabilitation and penile pain related to intracavernous alprostadil after radical prostatectomy. If a persons erectile dysfunction does not respond to remedy, they might be offered alprostadil. eleven. Jardin A, Wagner G, Khoury S, et al. Recommendations of the 1st ...
Viridal 10 Duo Starter Pack contains the active ingredient Alprostadil cause blood vessels to widen by relaxing the thin layer of muscle found in the vessel wall
Alprostadil only. If the patient achieves a normal erection as confirmed by the urologist then the patient has a clearcut psychological cause and requires counselling/or psychotherapy.. He may be advised and taught self injection with papavereine for a few weeks to improve his self confidence. Later it can be discontinued. Many patients experience recovery of spontaneous erection with PIPE. However a few things about PIPE need to be mentioned. The first few injections have to be supervized by the urologist. The exact dose needed has be decided by the urologist and the details of the method of injection. The erection produced should not last for more than 45 minutes to 1 hour. If it lasts for a longer time the patient has to report immediately. Persistent erection for more than one hour is called priaprism and has to be treated immediately. Another complication is the occurrence of fibrosis i.e. a small area of hardness at the site of injection.. PIPE cannot be given to patients with bleeding ...
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Lubiprostone is useful in treating patient with irritable bowel syndrome with chronic cases of constipation. Lubiprostone will aid in propulsive movement of the gut.
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Basic Rider Optimization Training for the Segway™ Human Transporter (HT) i Series, e Series and p Series models Instructor Guide and Participant Workbook Instructor Guide and Participant Workbook © Segway LLC 2002 Rev 3.5i - January 2004 P/N 1707100001aa Page 2 of 106 Basic Rider Optimization Training for the Segway HT Important information for e Series users To reduce the risk of injury, all users of e Series models should first complete training provided by a Segway authorized trainer. The Segway HT e Series has all the same components as the Segway HT i Series, and the following additional components and features: , , , , A Front Bag Frame and Front Bag A Lower Cargo Structure Two Side Bags An electronic parking stand, called E-Stand, that enables the e Series to balance itself (park) without a rider Please follow these recommendations: , , , , , , , Charge your Segway HT for a full 12 hours before the first use. Do not let anyone power on your Segway HT e Series Segway HT or try ...
***Partially updated 2/25/10*** TnC has begun an E Series project, the new EDC-Flex Series. We are providing very small runs of aluminum parts to parallel the Ti parts we are offering as well. These Ti parts (head and tubes/tails) have been discussed in our Titanium Aleph & E Series compatible heads/tubes/tails**Announcing TnC Ti EDC-Flex**The first post with details and pricing (for Ti) is listed here, and the general interest list is here on the 12th post. The 20mm EDC-Flex bare and
High blood pressure (BP) is a well-documented risk factor for cardiovascular disease (CVD) and chronic kidney disease progression. These associations, however,
Mineralogy and mineral chemistry data collected on unusual boninite samples (U1439C 15R-1, U1439C 25R-1) recovered during IODP Expedition 352 demonstrate highly variable mineral chemistries that suggest complex crystallization histories. The samples include early-crystallized olivines with embayed and reacted margins, some of which also show zoning (Fo87 cores; Fo77 rims), and large, euhedral pyroxene crystals, with clinoenstatite to pigeonite cores (En86 Fs12 Wo2, to En69 Fs12 Wo19), and augite rims (En43 Fs17 Wo40). Cr-rich spinels were found to be enclosed in both olivines and pyroxenes. These spinels show elevated Al2O3 and MgO contents (≈8-12%), suggesting early high pressure crystallization. Further EPMA studies of these and other Expedition 352 boninites, focused on spinel-olivine and spinel-pyroxene relationships, were conducted using the JEOL 8900R electron microprobe system at the Florida Center for Analytical Electron Microscopy (FCAEM) at Florida International University. Olivine-spinel
"Alprostadil". Drug Information Portal. U.S. National Library of Medicine. "Dinoprostone". Drug Information Portal. U.S. ... Types include: Prostaglandin E1 also known as alprostadil Prostaglandin E2 also known as dinoprostone Both types are on the ...
Alprostadil is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and supplies may ... Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when the threat of ... Prostanoids, including alprostadil, do not reduce the risk of limb amputation but may offer a slight improvement in rest-pain ... Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is ...
In the US, "yohimbe" preparations are sold as a dietary supplements for enhancing libido, for weight loss and as aids for bodybuilding; but "There is virtually no published research on yohimbe which supports these or any other claims".[9]:861 Often, these products explicitly claim to contain yohimbine.[8] Cohen et al. found that samples of brands sold in American brick-and-mortar stores contained highly variable amounts of yohimbine, and sometimes none at all.[8]:368 Labelling claims were often misleading.[8]:368 Similar results have been reported by other laboratories for products sold in the U.S., in other countries and on the internet.[15][16][17][18][19] One study found that many brands of "yohimbe" might not derive from the P. johimbe tree in the first place.[20] According to yet another source the yohimbe sold in markets in West Africa, where the tree grows, is frequently adulterated with other species of the genus Pausinystalia; these contain little yohimbine.[21] The amounts of alkaloid ...
The common, adverse drug reactions (side effects) are the same as with other PDE5 inhibitors. The frequent vardenafil-specific side-effect is nausea; the infrequent side effects are abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial edema, hypotension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, and priapism. One possibly serious, but rare, side effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated.[4] On 18 October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of vardenafil, and other PDE5 inhibitors.[5] ...
The FDA's approval of sildenafil in 1998[16] was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Subsequently, the FDA approved vardenafil in 2003,[17] and tadalafil in 2003. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Tadalafil was approved in 2009 in the United States for the treatment of pulmonary arterial hypertension[18] and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Tadalafil was discovered by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs that began in August 1991.[19][20] In 1993, the Bothell, Washington biotechnology ...
... , also known as thymoxamine, is a drug used in urology for the treatment of erectile dysfunction.[1] It is an α1-adrenergic antagonist.[2] In the United Kingdom, Moxisylte is marketed as Opilon (Archimedes Pharma UK Ltd) and is used for the short-term treatment of primary Reynaud's syndrome. This is a condition where the fingers and toes become discoloured and is triggered by responses to cold, or emotional distress. Opilon tablets help by improving blood circulation to the extremities.[3][4] ...
ALPROSTADIL 17. AMANTADINE HYDROCHLORIDE 18. AMIFOSTINE 19. AMIKACIN SULPHATE 20. AMILORIDE HYDROCHLORIDE ...
"Alprostadil (PGE1) for Maintaining Ductal Patency". Fredenburg, Tyler B.; Johnson, Tiffanie R.; Cohen, Mervyn D. (2011-03-01 ...
Alprostadil: commonly known as PGE1, is a naturally occurring prostaglandin and vasodilator. Alprostadil has not been added to ...
Retrieved February 8, 2018.CS1 maint: uses authors parameter (link) "Alprostadil". The American Society of Health-System ... alprostadil). Other medication groups reported are antihypertensives, antipsychotics (e.g., chlorpromazine, clozapine), ...
The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded ...
Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction. They are marketed under ...
alprostadil CAVERJECT Pharmacia & Upjohn apomorfin CP UPRIMA Abbot Laboratories sildenafil CP REVATIO (VIAGRA) Pfizer Limited ...
... also known as alprostadil. In addition to injections, there is an alprostadil suppository that can be inserted into the urethra ... Additionally, a cream combining alprostadil with the permeation enhancer DDAIP has been approved in Canada as a first line ...
PGE1 has a role in regulation of immune system function and is used as the medicine alprostadil. Unlike AA and EPA, DGLA cannot ...
Intracavernosal injections of alprostadil may be used by people for whom other treatments such as PDE5 inhibitors are ...
Alprostadil) binds G-protein linked cell surface receptors that activate adenylate cyclase to relax vascular smooth muscle. ...
... hydrochloride is a functional inactive excipient currently used in the topical drug Vitaros, an alprostadil vasodilator ...
Drugs such as alprostadil, a PGE-1 analog, can be used to keep a PDA open until the primary defect is corrected surgically.[ ...
... intracavernosal injection or intraurethral administration of alprostadil (prostaglandin E1), and surgery if necessary. ...
... alprostadil (INN) alrestatin (INN) Alrex alsactide (INN) Altace (Pfizer/Sanofi-Aventis) Altamist altanserin (INN) altapizone ( ...
In some countries, erectile dysfunction patients may be prescribed Alprostadil in injectable form, which is self-injected ...
G04BD09 Trospium G04BD10 Darifenacin G04BD11 Fesoterodine G04BD12 Mirabegron G04BD13 Desfesoterodine G04BE01 Alprostadil ...
... combinations C01EA01 Alprostadil C01EB02 Camphor C01EB03 Indometacin C01EB04 Crataegus glycosides C01EB05 Creatinolfosfate ...
If male patients insist that their penis is shrinking and disappearing, measurements after intracavernosal alprostadil may be ...
... alprostadil MeSH D10.251.355.255.550.250.200 - dinoprostone MeSH D10.251.355.255.550.400 - prostaglandins f MeSH D10.251. ... alprostadil MeSH D10.251.355.325.190 - capsaicin MeSH D10.251.355.325.200 - cilastatin MeSH D10.251.355.325.240 - crotonic ...
... alprostadil (intraurethral use), probucol, itraconazole, fenofibrate, acyclovir, simvastatin, xibornol, silymarin, alpha- ...
PGE1 as alprostadil). To measure erect penis size in a clinical environment To treat egg binding in small birds Cold exposure ...
... alprostadil MeSH D23.469.050.175.725.780.200 - dinoprostone MeSH D23.469.050.175.725.790 - prostaglandins f MeSH D23.469. ...
... or alprostadil This set index page lists chemical structure articles associated with the same molecular formula. If an internal ...
Alprostadil Urogenital: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Alprostadil injection should not be used more than three times per week, with at least 24 hours between uses. Alprostadil ... Your doctor may tell you not to use alprostadil.. *if you are using the alprostadil pellet, tell your doctor if you have or ... Alprostadil does not cure erectile dysfunction or increase sexual desire. Alprostadil does not prevent pregnancy or the spread ...
Alprostadil belongs to the E-series of prostaglandins, which cause blood vessels to dilate (widen). ... Prostin VR injection contains the active ingredient alprostadil, which belongs to a family of naturally-occurring hormones ... Prostin VR (alprostadil). Prostin VR injection contains the active ingredient alprostadil, which belongs to a family of ... Alprostadil is used to treat babies who have been born with a heart defect. It is given to keep open a blood vessel called the ...
After the alprostadil solution is mixed and the needle is inserted into the alprostadil bottle, turn the bottle with the ... Information about this alprostadil-intracavernosal-route. Pregnancy Category. Explanation. All Trimesters. C. Animal studies ... Alprostadil should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used ... Alprostadil for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for ...
Alprostadil Injection USP; Caverject; Muse Pellet; Prostin VR. ¿Para qué se usa este medicamento?. *Se utiliza para tratar la ... Si es alérgico al alprostadil o cualquier otro componente de este medicamento. ...
MUSE® (alprostadil) is a single-use, medicated transurethral system for the delivery of alprostadil to the male urethra. ... Long-term carcinogenicity studies of alprostadil have not been conducted. Alprostadil showed no evidence of mutagenicity in ... permitting alprostadil to be absorbed by the urethral mucosa. The transurethral absorption of alprostadil after MUSE ... Known hypersensitivity to alprostadil (the active medication in MUSE) • An abnormally formed penis • Have been advised not to ...
Detailed drug Information for alprostadil Urethral. Includes common brand names, drug descriptions, warnings, side effects and ... Proper Use of alprostadil. Use alprostadil exactly as directed by your doctor. Do not use more of it, do not use it more often ... Alprostadil is available only with your doctors prescription.. Before Using alprostadil. In deciding to use a medicine, the ... Precautions While Using alprostadil. Do not use alprostadil suppositories if you have a penile implant unless advised by doctor ...
... alprostadil injection, solution), including warnings and precautions, directions, and the names of other drugs and products ...
Alprostadil official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... No unchanged Alprostadil has been found in the urine, and there is no evidence of tissue retention of Alprostadil or its ... Alprostadil must be infused continuously because it is very rapidly metabolized. As much as 80% of the circulating Alprostadil ... Alprostadil - Clinical Pharmacology. Alprostadil (prostaglandin E1) is one of a family of naturally occurring acidic lipids ...
Alprostadil Injection) includes uses, warnings, and drug interactions. ... Caverject (alprostadil) is a naturally occurring form of prostaglandin used to treat erectile dysfunction (impotence) and to ... Our Caverject (alprostadil) Side Effects Drug Center provides a comprehensive view of available drug information on the ... home drugs a-z list Caverject(Alprostadil Injection) side effects drug center ...
More common side effects of alprostadil include a painful erection and short-term bleeding at the injection site, according to ... More common side effects of alprostadil include a painful erection and short-term bleeding at the injection site, according to ... Other possible side effects of alprostadil urethral include rapid heartbeat, swelling of the leg veins and spotting from the ... Patients should contact a doctor immediately if they experience fainting while using alprostadil. Female partners may also ...
Alprostadil Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... alprostadil) for Injection, for Intracavernosal Use. DESCRIPTION. CAVERJECT contains alprostadil a synthetic form of ... Following intracavernosal injection of 20 mcg alprostadil, mean peripheral plasma concentrations of alprostadil at 30 and 60 ... Plasma levels of alprostadil were measured using a radioimmunoassay method. Alprostadil is bound in plasma primarily to albumin ...
Find the most comprehensive real-world treatment information on Alprostadil at PatientsLikeMe. 4 patients with fibromyalgia, ... gastroesophageal reflux disease or bipolar I disorder currently take Alprostadil. ... Currently taking Alprostadil Duration. Patients. This item is relevant to you: 2 - 5 years 1 * 1 ... Stopped taking Alprostadil Duration. Patients. This item is relevant to you: 1 - 6 months 1 * 1 ...
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Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV (ESPECIAL). Phase 4. SP0777 Completed NCT00596752. 2005- ... Alprostadil in Maculopathy Study (AIMS). Phase 3. SP0878 Terminated NCT00619229. 2005-005686-11 ...
Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil ... Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. ... This medication guide addresses only the adult male use of alprostadil in erectile disorders.. You should not use alprostadil ... Alprostadil is used only when needed. An erection should occur within 5 to 20 minutes and last up to 60 minutes.. Alprostadil ...
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Alprostadil in Peripheral Arterial Occlusive Disease (PAOD) Stage IV (ESPECIAL). The safety and scientific validity of this ... Experimental: Alprostadil Prostavasin® 40 μg will be infused intravenously twice daily over 2 hours in 50 to 150 ml isotonic ... The study is to confirmatorily show a superior effect of Alprostadil compared to placebo on the rate of complete healing of ... Efficacy and Safety of Alprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage IV: Results of a ...
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A total of 35 patients with pure vasculogenic impotency were randomly assigned to alprostadil (Av group; n=11), sildenafil (Sv ... Our results suggest that alprostadil and oral therapy should be the starting therapy in men with vasculogenic impotency, ... Av and A used alprostadil injection (capable of giving a full erection) once a week for 1 month, Sv and S took daily oral ... whereas alprostadil should be avoided as the first-line approach in men with nonvasculogenic impotency. ...
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The median alprostadil treatment period was 1.8 months. The 1‑year amputation-free survival was 41%. In 36% of patients an ... Alprostadil treatment of critical limb ischemia in hemodialysis patients. A retrospective single-center analysis. Zeitschrift: ... Despite alprostadil treatment, 36% of the study patients additionally underwent an endovascular procedure and 16% had bypass ... Despite treatment with alprostadil the mortality, amputation rate and the need for revascularization procedures in hemodialysis ...
Get up-to-date information on Alprostadil side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about ... Alprostadil is a prescription medication used to certain types of erectile dysfunction. Alprostadil belongs to a group of drugs ... Serious side effects have been reported with alprostadil.. Common side effects of alprostadil include the following:. *aching ... How was your experience with Alprostadil?. First, a little about yourself. Male Female ...
Issues Voluntary Nationwide Recall for One Lot of Edex® (alprostadil for injection) 10 mcg 2 Pack Carton Due to Potential Lack ...
Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil Abstract ... Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil. Irena ... The patient required intensification of intravenous rheological treatment with alprostadil and oral usage of sildenafil, which ... 2017) Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil. J ...
  • Guaifenesin: (Moderate) Pain medications that contain opiate agonists may intensify CNS depressive adverse effects seen with gabapentin use, alprostadil rezeptfrei kaufen such as drowsiness or dizziness. (harrietpattison.com)
  • In advanced cases, alprostadil kaufen microcystic epithelial edema may be present as well. (marenostrum.com.tr)
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  • Alprostadil injection is also sometimes used in combination with other tests to diagnose erectile dysfunction. (medlineplus.gov)
  • Alprostadil does not cure erectile dysfunction or increase sexual desire. (medlineplus.gov)
  • Alprostadil injection is used to treat men who have erectile dysfunction (also called sexual impotence). (mayoclinic.org)
  • Alprostadil should not be used as a sexual aid by men who do not have erectile dysfunction. (mayoclinic.org)
  • Alprostadil is used alone or with medical tests to help diagnose erectile dysfunction that may be caused by nerve or blood vessel problems in the penis. (mayoclinic.org)
  • Caverject (alprostadil) is a naturally occurring form of prostaglandin used to treat erectile dysfunction ( impotence ) and to help diagnose certain causes of this disorder. (rxlist.com)
  • Viridal Duo (alprostadil) is a prescription only treatment to help you get and maintain an erection if you suffer from erectile dysfunction. (pharmacy2u.co.uk)
  • ALPROSTADIL (al PROS ta dil) is used to treat erectile dysfunction (ED). This medicine helps to create and maintain an erection. (ahealthyme.com)
  • We compared the effectiveness of sildenafil citrate and alprostadil in improving arterial penile inflow (peak systolic velocity (PSV)) and penile rigidity in 55 patients with erectile dysfunction caused by atherosclerosis. (nature.com)
  • The first topical cream approved for the treatment of erectile dysfunction (ED) in men over the age of 18 years, Vitaros® (topical alprostadil cream), is now available for prescription in the UK. (medicalnewstoday.com)
  • The Company is in late stage development for Vitaros, its topically applied NexACT-based alprostadil treatment for erectile dysfunction. (fiercebiotech.com)
  • Alprostadil treats erectile dysfunction and rare genetic heart diseases. (rxwiki.com)
  • Alprostadil is a prescription medication used to certain types of erectile dysfunction . (rxwiki.com)
  • Caution - Alprostadil Injection CAN NOT be used by those people who don't have any Erectile dysfunction. (brightfuturesforfamilies.org)
  • If you have erectile dysfunction and are looking for help, Alprostadil is the best known drug used to treat problems with male sexual functions. (erectiledysfunctionclinics.co.uk)
  • Alprostadil is a medication used to treat impotence (erectile dysfunction) in men and is also intended to identify the possible causes of this disorder. (termsreign.gq)
  • Alprostadil injection USP for intravascular infusion contains 500 micrograms Alprostadil, more commonly known as prostaglandin E 1 , in 1 mL dehydrated alcohol. (drugs.com)
  • Alprostadil (prostaglandin E 1 ) is one of a family of naturally occurring acidic lipids with various pharmacologic effects. (drugs.com)
  • CAVERJECT contains alprostadil a synthetic form of prostaglandin E 1 (PGE 1 ) and is designated chemically as(11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid. (rxlist.com)
  • The active ingredient of Viridal Duo, alprostadil, is like the natural substance prostaglandin E1. (pharmacy2u.co.uk)
  • Bassam Damaj, Ph.D., President and Chief Executive Officer of NexMed, stated, "Given the disease characteristics, Raynaud's syndrome is an appealing product opportunity for us and one that we believe can benefit strongly from the active ingredient in Vitaros, which is alprostadil, or prostaglandin E1 (PGE1), a potent vasodilator. (fiercebiotech.com)
  • Alprostadil belongs to a vasodilators medicine category, contains prostaglandin E1 that stimulates blood vessels to expand by relaxing the layer of muscles in the wall of the blood vessels. (brightfuturesforfamilies.org)
  • Its active ingredient alprostadil, is similar to the natural substance prostaglandin E1 in your body. (medix24.com)
  • Alprostadil (Prostaglandin E1) is used primarily to keep patency of ductus arteriosus but also has a mild pulmonary vasodilatory effect. (medscape.com)
  • Types include: Prostaglandin E1 also known as alprostadil Prostaglandin E2 also known as dinoprostone Both types are on the World Health Organization's List of Essential Medicines. (wikipedia.org)
  • Prostaglandin E1 (PGE1), also known as alprostadil, is a naturally occurring prostaglandin which is used as a medication. (wikipedia.org)
  • MUSE ® (alprostadil) is a single-use, medicated transurethral system for the delivery of alprostadil to the male urethra. (nih.gov)
  • About 80% of alprostadil administered by MUSE is absorbed within 10 minutes and is rapidly cleared from the systemic circulation by the lungs, leaving barely detectable systemic blood levels. (nih.gov)
  • The syndrome includes IC, alprostadil muse video which has been estimated to affect as many as 700,000 people, mostly women? (harrietpattison.com)
  • In suppository form, Alprostadil is known as MUSE. (erectiledysfunctionclinics.co.uk)
  • Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is needed. (wikipedia.org)
  • One product called Alprostadil for Injection (brand names Caverject® and Edex®) is available as a powder in a vial. (explainingmedicine.com)
  • Alprostadil pellets should not be used more than twice in a 24-hour period. (medlineplus.gov)
  • Your doctor will probably tell you not to use alprostadil pellets. (medlineplus.gov)
  • While using alprostadil pellets, use condoms during sex if your partner is pregnant or able to get pregnant. (everydayhealth.com)
  • Do not use more than 2 alprostadil pellets in one day (24 hours). (adventisthealthcare.com)
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  • Do not use more than 3 alprostadil injections per week. (adventisthealthcare.com)
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  • For the injections -There are several alprostadil products that can be injected. (explainingmedicine.com)
  • Alprostadil can be used in the form of suppositories, injections, or a cream. (mycanadianpharmacyrx.com)
  • Alprostadil used in the form of injections promotes the occurrence of an erection that lasts during the whole sexual intercourse in 80% of men suffering from sexual dysfunction, regardless of their age and the reasons for the problem. (mycanadianpharmacyrx.com)
  • Alprostadil used in the form of suppositories is less effective than the injections and leads to an erection in 30-40% of men suffering from impotence. (mycanadianpharmacyrx.com)
  • How Does Alprostadil Work in the Form of Injections? (mycanadianpharmacyrx.com)
  • When using alprostadil in the form of injections, the drug is injected through the wall of the penis with a syringe and a needle. (mycanadianpharmacyrx.com)
  • Hypotension - injections of CAVERJECT IMPULSE can lead to increased peripheral blood levels of alprostadil, especially in patients with significant corpora cavernosa venous leakage. (pfizermedicalinformation.com)
  • In a primarily elderly Scandinavian population, alprostadil injection dosage the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) study showed significant overall mortality benefit in subjects aged >60 years when using a combination regimen of calcium channel blocker and ACEI, when compared to a beta-blocker and thiazide regimen? (ambassador-technologies.com)
  • For these reasons, alprostadil generico prezzo and to target treatments in the three modalities expressed above, it has been much more effective in clinical practice to combine several antifungal medicines simultaneously! (rpturfcare.com)
  • 9 All isolates of strain 29B were homogenous with respect to RAPD pattern and virulence gene profile ( fimA , alprostadil generico iutA ) and belonged to phylogenetic group D? (southingtondigital.com)
  • Alprostadil comes as a powder to be mixed with the liquid provided in the package and injected into the penis and as a urethral suppository (pellet to be placed into the urinary opening of the penis). (medlineplus.gov)
  • if you are using the alprostadil pellet, tell your doctor if you have or have ever had any narrowing, scarring, or swelling of the urinary opening of the penis or the tip of the penis. (medlineplus.gov)
  • Alprostadil causes an erection because it increases the blood flow to the penis. (drugs.com)
  • Other possible side effects of alprostadil urethral include rapid heartbeat, swelling of the leg veins and spotting from the penis, according to WebMD. (reference.com)
  • Alprostadil relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection. (everydayhealth.com)
  • You should not use alprostadil if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you must avoid sexual intercourse for health reasons. (everydayhealth.com)
  • Alprostadil injection is injected into the side of the penis. (everydayhealth.com)
  • You should not use this medicine if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons. (adventisthealthcare.com)
  • Alprostadil relaxes blood vessels and muscles in the penis. (adventisthealthcare.com)
  • After applying the pre-measured amount of cream (100μl) to the tip of the penis, the new skin permeation technology within the cream (NexACT®-DDAIP) results in the rapid absorption of alprostadil by loosening the epidermal tight junctions, producing an erection within 5-30 minutes. (medicalnewstoday.com)
  • Many men are also put off by the existing administration methods for alprostadil, such as an injection into the penis or a pellet inserted into the urethra. (medicalnewstoday.com)
  • Alprostadil only used by doctors after performing certain tests that prove that the patient is suffering with blood vessel problems in the penis. (brightfuturesforfamilies.org)
  • Alprostadil stimulates blood vessels through a multifaceted chain of chemical reactions and that directly intercept the signals from the nervous system urging the releasing the chemicals into the cells of the penis. (brightfuturesforfamilies.org)
  • Alprostadil is available as an injection treatment, which is where you inject Alprostadil into the base of your penis. (pianolarge.gq)
  • It is available as a urethral application, which is where you place a small pellet containing Alprostadil into your urethra (the tube which your urine passes through and which opens at the end of your penis). (pianolarge.gq)
  • Alprostadil acts by relaxing blood vessels in the muscle walls of the penis, increasing the blood flow to the penile area and therefore inducing an erection. (termsreign.gq)
  • Thus, increasing the blood flow to the penis, alprostadil promotes the occurrence of an erection. (mycanadianpharmacyrx.com)
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  • What are some side effects of Alprostadil? (reference.com)
  • More common side effects of alprostadil include a painful erection and short-term bleeding at the injection site, according to Drugs.com. (reference.com)
  • Common side effects of alprostadil include lower body aches, warmth or burning sensation in the urethra, and light headedness or dizziness. (rxwiki.com)
  • Knowledge discovery in databases aims at tearing down the last barrier in enterprises' information flow, alprostadil pentravan the data analysis step? (prayeristheanswers.com)
  • Prostin VR injection contains the active ingredient alprostadil, which belongs to a family of naturally-occurring hormones called prostaglandins. (netdoctor.co.uk)
  • Dans la nouvelle formulation pharmaceutique étant probablement, alprostadil drug class l'homme se spécialisant peut être admis mieux par Cialis et peut travailler plus vite. (ebonyhistories.com)
  • Our Caverject (alprostadil) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • This medication guide addresses only the adult male use of alprostadil in erectile disorders. (everydayhealth.com)
  • Alprostadil may also be used for purposes not listed in this medication guide. (everydayhealth.com)
  • This medication comes in both cream and vaginal tablet form, alprostadil cream buy which comes with an applicator? (prayeristheanswers.com)
  • Valtrex, alprostadil injection manufactured by GlaxoSmithKline, was approved by the FDA in 1995 and was the 2nd antiviral medication to come to market in the USA! (shahtez.com)
  • Despite treatment with alprostadil the mortality, amputation rate and the need for revascularization procedures in hemodialysis patients with critical limb ischemia remained high. (springermedizin.at)
  • The patient required intensification of intravenous rheological treatment with alprostadil and oral usage of sildenafil, which had a positive effect on the improvement of the impaired microcirculation. (omicsonline.org)
  • It is also important that you give up using heavy machinery and driving as treatment with Alprostadil continues. (erectiledysfunctionclinics.co.uk)
  • This genomic DNA test assesses your genetic response to medical treatment with alprostadil. (genomicmedicineuk.com)
  • How does your genetic background influence your response to treatment with alprostadil? (genomicmedicineuk.com)
  • Priapism, history of-Patients with these conditions have an increased risk of priapism (erection lasting longer than 6 hours) while using alprostadil. (mayoclinic.org)
  • n =10): Av and A used alprostadil injection (capable of giving a full erection) once a week for 1 month, Sv and S took daily oral sildenafil (25 mg) for 1 month, and P took daily oral placebo for one month. (nature.com)
  • In the long-term open label study, the majority (90 percent) of men using 300mcg of topical alprostadil for six months considered their erection improved compared to their erection at the beginning of the trial (measured by GAQ). (medicalnewstoday.com)
  • A retrospective single-center analysis of hemodialysis patients with critical limb ischemia was performed who were treated with the prostanoid analogue alprostadil as an infusion during hemodialysis in the period from 2000 to 2013. (springermedizin.at)
  • One chamber contains alprostadil, the other contains sodium chloride solution. (pharmacy2u.co.uk)
  • These results suggest that intraurethral alprostadil is absorbed from the urethra, transported throughout the erectile bodies by communicating vessels between the corpus spongiosum and corpora cavernosa, and able to induce vasodilation of the targeted vascular beds. (nih.gov)
  • Recovery of erectile function after nerve sparing radical prostatectomy and penile rehabilitation with nightly intraurethral alprostadil versus sildenafil citrate. (druglib.com)
  • PURPOSE: To our knowledge we report the first large, randomized, prospective penile rehabilitation clinical trial to compare the effectiveness of nightly intraurethral alprostadil vs sildenafil citrate after nerve sparing prostatectomy. (druglib.com)
  • Subjects initiated nightly treatment within 1 month of surgery with intraurethral alprostadil or oral sildenafil citrate (50 mg) for 9 months. (druglib.com)
  • RESULTS: Of 139 men who started intraurethral alprostadil and 73 who started sildenafil citrate, 97 and 59, respectively, completed the trial. (druglib.com)
  • There were no statistically significant differences in International Index of Erectile Function erectile function domain and intercourse success rates to intraurethral alprostadil. (druglib.com)
  • The use of nightly subtherapeutic intraurethral alprostadil is well tolerated after radical prostatectomy. (druglib.com)
  • The benefit to return of erectile function of nightly sildenafil citrate and subtherapeutic intraurethral alprostadil appears to be comparable within the first year of surgery. (druglib.com)
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  • Suitable methods for introducing isolated nucleic acids into host cells are known to those of skill in the art and include, alprostadil ampolla but are not limited to, natural competency, calcium chloride transformation, protoplast transformation, electroporation, conjugation, and generalized and specialized transduction (eg, see Sambrook et al? (wrightarchitects.net)
  • Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet (micro-suppository measuring 1.4 mm in diameter by 3 mm or 6 mm in length) that resides in the tip of a translucent hollow applicator. (nih.gov)
  • Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. (adventisthealthcare.com)
  • Using an alprostadil transurethral pellet improperly could cause damage to your urethra. (adventisthealthcare.com)
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  • Urine is produced by the kidneys, alprostadil pulmonary hypertension a pair of bean-shaped organs that are located at the bottom of the ribcage in the right and left sides of the back? (loshightops.com)
  • Your doctor will administer the first dose of alprostadil in his or her office to determine the proper dose for you. (medlineplus.gov)
  • After you begin to use alprostadil at home, your doctor may gradually increase or decrease your dose. (medlineplus.gov)
  • In vitro , alprostadil (PGE 1 ) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. (nih.gov)
  • When alprostadil was injected into the corpus cavernosum of pigtail monkeys in vivo, dose-dependent increases in cavernosal artery blood flow were observed. (nih.gov)
  • CAVERJECT is available in single-dose vials containing 20 mcg or 40 mcg of alprostadil. (rxlist.com)
  • Prepare your alprostadil dose only when you are ready to use the medicine. (adventisthealthcare.com)
  • Conducted in Chinese healthy adult volunteers,the study aims to observe the safety, tolerability and pharmacokinetic of single-dose administration of different doses of Alprostadil Liposome for Injection as well as to confirm the safety dose range. (clinicaltrials.gov)
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  • After intravenous administration of alprostadil at a dose of 60 μg / 2 h, the maximum plasma concentration of healthy volunteers exceeded the maximum concentration in the placebo phase (2.4 pg / ml) by 6 pg / ml. (pillbuys.com)
  • introduction The daily dose is 40 mcg of alprostadil 2 times a day or 60 mcg of alprostadil 1 time a day. (pillbuys.com)
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  • The study is to confirmatorily show a superior effect of Alprostadil compared to placebo on the rate of complete healing of ischemic necroses and ulcerations as well as on the frequency and height of major amputations in patients suffering from PAOD stage IV. (clinicaltrials.gov)
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  • The subject will then return for the 1st treatment visit at which time vital signs like blood pressure and heart rate will be taken, external genitalia will be examined and study drug will be dispensed after randomly being assigned to either alprostadil or placebo. (clinicaltrials.gov)
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