A potent vasodilator agent that increases peripheral blood flow.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
The sexual union of a male and a female, a term used for human only.
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Drugs used to cause dilation of the blood vessels.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro. (1/875)

1. The thienopyridine clopidogrel is a specific inhibitor of ADP-induced platelet aggregation ex vivo. No direct effects of clopidogrel (< or = 100 microM) on platelet aggregation in vitro have been described so far. 2. Possible in vitro antiaggregatory effects (turbidimetry) of clopidogrel were studied in human platelet-rich plasma and in washed platelets. 3. Incubation of platelet-rich plasma with clopidogrel (< or = 100 microM) for up to 8 h did not result in any inhibition of ADP (6 microM)-induced platelet aggregation. 4. Incubation of washed platelets with clopidogrel resulted in a time- (maximum effects after 30 min) and concentration-dependent (IC50 1.9+/-0.3 microM) inhibition of ADP (6 microM)-induced platelet aggregation. Clopidogrel (30 microM) did not inhibit collagen (2.5 microg ml(-1))-, U46619 (1 microM)- or thrombin (0.1 u ml(-1))-induced platelet aggregation. The inhibition of ADP-induced aggregation by clopidogrel (30 microM) was insurmountable indicating a non-equilibrium antagonism of ADP actions. The R enantiomer SR 25989 C (30 microM) was significantly less active than clopidogrel (30 microM) in inhibiting platelet aggregation (32+/-5% vs 70+/-1% inhibition, P < 0.05, n = 5). 5. In washed platelets, clopidogrel (< or = 30 microM) did not significantly reverse the inhibition of prostaglandin E1 (1 microM)-induced platelet cyclic AMP formation by ADP (6 microM). 6. The antiaggregatory effects of clopidogrel were unchanged when the compound was removed from the platelet suspension. However, platelet inhibition by clopidogrel was completely abolished when albumin (350 mg ml(-1)) was present in the test buffer. 7. It is concluded that clopidogrel specifically inhibits ADP-induced aggregation of washed platelets in vitro without hepatic bioactivation. Inhibition of ADP-induced platelet aggregation by clopidogrel in vitro occurs in the absence of measurable effects on the reversal of PGE1-stimulated cyclic AMP by ADP.  (+info)

Oxytocin-induced Ca2+ responses in human myometrial cells. (2/875)

Complex spatiotemporal changes in intracellular Ca2+ were monitored in an immortalized human myometrial cell line (PHM1-41) and first-passage human myometrial cells after oxytocin stimulation (1. 0-1000 nM). Laser cytometry revealed intracellular Ca2+ oscillations in both culture systems starting at 1.0 nM, which were followed by repetitive Ca2+ transients by 10-15 min that lasted for at least 90 min. The amplitude of the initial Ca2+ spike was dose dependent, while the frequency of Ca2+ oscillations identified by Fast Fourier Transform (FFT) tended to increase with dose. Removal of oxytocin resulted in termination of oscillations. Analysis of the sources of the Ca2+ involved in oscillations indicated that the major contribution to oscillation frequencies of +info)

Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta. (3/875)

A number of cytokines and their receptors are abundantly expressed at the materno-fetal interface and are thought to have a function in the regulation of placentation. Granulocyte-colony stimulating factor (G-CSF) is expressed by stromal cells in both placental tissue and maternal decidua throughout placentation. In this study, we examined the expression of placental G-CSF receptor (G-CSFR) mRNA and protein throughout gestation by ribonuclease protection assays, Western blotting, and immunohistochemistry. The major placental form of G-CSFR mRNA, corresponding to a membrane-bound form of the protein, was present in first-trimester placental tissues; levels decreased in second- and were highest in third-trimester placental tissues. Two placental G-CSFR molecules, 120 kDa and 150 kDa, were detected in first- and third-, but not second-, trimester tissues. The level of the 150-kDa G-CSFR was greater in the third- than in first-trimester samples. These differences were irrespective of whether or not the patients had received prostaglandin E1 analogues, prostaglandin E1 analogues and oxytocin, oxytocin alone, or mifepristone before labor. We demonstrated by immunohistochemistry that interstitial cytotrophoblast in first- and second-trimester decidual tissue and cytotrophoblast in term fetal membranes express G-CSFR. These data demonstrate that the expression of specific forms of placental G-CSFR is strictly cell type- and developmental stage-specific, and they suggest that G-CSFR may be important in decidual invasion of cytotrophoblast and in trophoblast function during placentation.  (+info)

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (4/875)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. (5/875)

1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat. 2. One hundred and sixty-seven, male Wistar rats were anaesthetized (thiopentone, 120 mg kg(-1) i.p.), ventilated (8-10 ml kg(-1), 70 strokes min(-1), inspiratory oxygen concentration: 30%; PEEP: 1-2 mmHg) and subjected to occlusion of the left anterior descending coronary artery (LAD, for 7.5, 15, 25, 35, 45 or 60 min) followed by reperfusion (2 h). Infarct size was determined by staining of viable myocardium with a tetrazolium stain (NBT), histological evaluation by light and electron microscopy and determination of the plasma levels of cardiac troponin T. 3. M&B 28767 (0.5 microg kg(-1) min(-1), i.v., n=7) or GR 63799X (3 microg kg(-1) min(-1), i.v., n=7) caused significant reductions in infarct size from 60+/-3% (25 min ischaemia and 2 h reperfusion; saline-control, n=8) to 39+/-6 and 38+/-4% of the area at risk, without causing a significant fall in blood pressure. Pretreatment of rats with 5-hydroxydecanoate (5-HD), an inhibitor of ATP-sensitive potassium channels, attenuated the cardioprotective effects of both EP3-receptor agonists. The reduction in infarct size afforded by M&B 28767 was also abolished by glibenclamide and the protein kinase C (PKC) inhibitors staurosporine and chelerythrine. 4. Thus, M&B 28767 and GR 63799X reduce myocardial infarct size in the rat by a mechanism(s) which involves the activation of PKC and the opening of ATP-sensitive potassium channels.  (+info)

Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm. (6/875)

We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere (Lipo-PGE1) in relation with transcranial Doppler parameters such as mean flow velocity (MFV) and pulsatile index (PI) of the proximal segment of the middle cerebral artery. Eighty patients with subarachnoid hemorrhage (SAH) were included in this study. In the case of angiographic vasospasm, papaverine at 7 mg/min with total dose below 300 mg per artery and 10-20 micrograms of Lipo-PGE1 were injected in the supraclinoid portion of the internal carotid artery. Vasospasm was improved in 24 patients (63%), however, it was unchanged in 14 patients (37%). The former patients had more favorable outcomes than the latter patients (p < 0.005). After intracarotid injection therapy, the correlation between MFV and PI was classified into three types: type 1, both MFV and PI decreased; type 2, MFV decreased but PI increased; and type 3, both MFV and PI fluctuated. The Glasgow Outcome Scale 3 months after SAH was as follows: type 1 (n = 15), good in 14 (93%) and moderate disability in one (7%); type 2 (n = 9), good in eight (89%) and vegetative state in one (11%); and type 3 (n = 14), moderate disability in five (36%), severe disability in seven (50%), and death in two (14%). Chi-square analysis showed significant differences between type 1 and type 3 (p < 0.005), and type 2 and type 3 (p < 0.005). In conclusion, intracarotid papaverine combined with Lipo-PGE1 was effective for vasospasm but type 3 patients require a different treatment protocol.  (+info)

Platelet-stimulated thrombin and PDGF are normalized by insulin and Ca2+ channel blockers. (7/875)

Coronary artery disease is accelerated in chronic spinal cord injury (SCI). Because prostacyclin (PGI2) may retard atherogenesis through its inhibitory effects on platelet function, the role of PGI2 on SCI platelets was determined. The SCI platelets were neither hypersensitive to aggregating agonists nor resistant to the inhibitory effect of PGI2, but PGI2 failed to inhibit platelet-stimulated thrombin generation and the release of platelet-derived growth factor (PDGF) in SCI. Because thrombin and PDGF are atherogenic mitogens, the generation of these mitogens was investigated. Both the release of PDGF and thrombin generation in SCI platelets were higher when compared with control (n = 12). Treatment of non-SCI platelets with 100 nM PGE1 (a stable probe of PGI2) inhibited the release of the mitogens by 90% (P < 0.001), with no effect on SCI platelets. Scatchard analysis of prostaglandin E1 (PGE1) binding showed a 70% decrease of PGI2 receptors on the SCI platelet surface. Treatment of SCI platelets with insulin or Ca2+ channel blockers restored the PGI2-receptor number and "normalized" the inhibition of PDGF release and thrombin generation by PGI2.  (+info)

Seminal plasma components stimulate interleukin-8 and interleukin-10 release. (8/875)

Human seminal plasma has potent anti-inflammatory properties which are thought to confer a survival advantage to the spermatozoa within the hostile female genital tract. In contrast, a profound pro-inflammatory leukocytosis has been observed post-coitus in animals and humans. Whether components of seminal plasma are involved in initiating this leukocytic reaction is not known. This study investigated the effect of human seminal plasma, a seminal plasma fraction and its principal constituent prostaglandins, prostaglandin E2 (PGE2) and 19-hydroxy PGE, on the release of the pro-inflammatory neutrophil chemotactic factor interleukin-8 (IL-8) and the anti-inflammatory cytokines interleukin-10 (IL-10) and secretory leukocyte protease inhibitor (SLPI). The tissues studied were non-pregnant cervical explants, peripheral blood and the monocyte cell line U937. Seminal plasma fraction (SPF) significantly (P < 0.05) stimulated release of IL-8 and inhibited release of SLPI from non-pregnant cervical explants. SPF, PGE2 and 19-hydroxy PGE significantly (P< 0.005) stimulated IL-8 release from peripheral blood and U937 cells. 19-hydroxy PGE was significantly (P< 0.005) more effective than PGE2 in stimulating IL-8 release. Seminal plasma, SPF and PGE2 significantly (P < 0.05) stimulated IL-10 release from U937 cells. 19-hydroxy PGE stimulated IL-10 release from U937 cells but this failed to reach significance. Release of IL-10 by cervical explants and SLPI by peripheral blood and U937 cells were below the detection limit of the assays employed. We suggest that the anti- and pro-inflammatory immune responses which seminal plasma induces might act in combination initially to promote sperm survival and then to facilitate their removal from the female genital tract.  (+info)

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Female sexual arousal disorder (FSAD) is a frequent finding in women in middle age and more prevalent in post-menopausal women. Topical alprostadil is currently under development for the treatment of FSAD. The purpose of this research is to determine if this formula of alprostadil is safe and effective in women with FSAD. We will be comparing alprostadil to placebo. Each participant will be treated for 1 month with active alprostadil and 1 month with placebo without knowing which they are using. This way, the investigators can compare the effects of alprostadil to the effects of an inactive topical gel.. Post-menopausal women with FSAD will be recruited. The women interested in participating in the study will first meet with investigators and answer questions to make sure they are eligible for the study and fit the diagnosis of FSAD.. Once enrolled, subjects will fill out questionnaires about their medical history, social history, and psychosocial history. They will also undergo medical ...
Buy Alprostadil Online! Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition.
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Using too much alprostadil can be very dangerous.. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.. The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).. Your first dose of this medicine will be given in your doctors office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an ...
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Buy Alprostadil Online! Alprostadil, also known as Prostaglandin E1, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out.
Buy Alprostadil Online! Alprostadil, also known as Prostaglandin E1, is a naturally occurring prostaglandin which is used as a medication. In babies with congenital heart defects, it is used by slow injection into a vein to open the ductus arteriosus until surgery can be carried out.
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Buy Alprostadil Online! Alprostadil is a medicine that men take for ED (erectile dysfunction). This drug makes the blood vessels expand. Its only available by prescription.
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Alprostadil is injected into the side of penis with a very fine needle. Its of great value to have the first shot in the doctors office before doing this on your own. Self-injection lessons should be given in your doctors office by an experienced professional. The success rate for getting an erection firm enough to have sex is as high as 85% with this treatment. Many men who do not respond to oral PDE5 inhibitors can be rescued with ICI.. ICI Alprostadil may be used as a mixture with two other drugs to treat ED. This combination therapy called bimix or trimix is stronger than alprostadil alone and has become standard treatment for ED. Only the Alprostadil ingredient is FDA approved for ED. The amount of each drug used can be changed based on the severity of your ED, by an experienced health professional. You will be trained by your health professional on how to inject, how much to inject and how to safely raise the drugs dosage if necessary.. ICI therapy often produces a reliable ...
Buy Alprostadil Online! This medication is used to treat male sexual function problems (erectile dysfunction). It works by helping the blood flow into the penis to achieve and maintain an erection. This medication is not for use in women or children. This medication is not recommended for use in men with penile implants.
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Caverject Impulse with NDC 0009-5182 is a a human prescription drug product labeled by Pharmacia And Upjohn Company Llc. The generic name of Caverject Impulse is alprostadil.
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10 Intracorporeal Injections Montorsi. and colleagues were the first to show human data supporting penile rehabilitation in their published randomized trial comparing men using intracavernosal injections of alprostadil three times weekly for 12 weeks after radical prostatectomy with those using no treatment.34 At the conclusion of the study, they found 67% of the patients in the injection therapy arm had natural Inhibitors,research,lifescience,medical erections sufficient for intercourse at 6 months, as compared with 20% in the control arm of the study. Doppler penile ultrasound on these patients at the conclusion of the study showed that patients who failed to recover erectile function had venous leak. Mulhall and colleagues performed a nonrandomized study in patients who were nonresponders to sildenafil.37 These patients were switched to intracorporeal. injection (ICI) therapy with alprostadil (3 times/week). These patients had to be followed for a minimum of 18 months and had to complete at ...
Choose a different place of injection each time you use the medicine to prevent skin problems. This includes switching the place of injection from the right side of the penis for one injection to the left side for the next injection. After a single-use injection is mixed, the medicine must be used immediately. Throw away any unused mixture in the syringe. It cannot be stored for a later injection. Do not reuse or share your needles or cartridges. Never use a bent needle and never try to straighten a bent needle prior to injecting. How to throw away the syringes and bottles safely:. Dispose of your materials properly. Caverject® comes in a plastic case that can be permanently locked with the red locking device that is included with the packaging. When the case label is removed, you can see a hole in the center of the case. The red locking device can be inserted and, by firmly pressing it down with your thumb, you will permanently lock the case. The locked case is safe to be thrown away.. This ...
Patients not responding to oral therapy may be offered ICIs, and prostaglandin E1 (alprostadil) is the most common drug; different formulations include Bimix (papaverine and phentolamine) and Trimix (alprostadil, papaverine and phentolamine).
MUSE: Alprostadil belongs to a family of medications known as prostaglandins. Prostaglandins like alprostadil cause increased blood flow to certain areas of the body by causing the blood vessels in the area to widen. This medication is used to treat erectile dysfunction by causing increased blood flow to the penis in particular.
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These tablets are prescription only. You will be required to send us your private prescription before we can dispense. If you do not have a private prescription you need to purchase an Erectile Dysfunction Prescription from the Relat
Dr is recommending Tri mix penile injections after 13 + years using oral ED meds, that approach no longer working. Good blood flow testing says, great nocturnal erections, can get erection with Viagra, but cant maintain for 1-5 min. Dr says Tri mix should work. Any body here willing to share experience pros cons etc? On TRT for 8 months no change on ED issue (was not the reason for starting TRT), Thanks
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NEXMED TO DISCUSS P2/3 PROTOCOL FOR NEXACT® -BASED ALPROSTADIL TREATMENT FOR RAYNAUDS SYNDROME WITH THE FDA San Diego--(BUSINESS WIRE)-- NexMed, Inc. (Nasdaq: NEXM), a specialty CRO with a
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An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
Doctors determine the proper dose of Caverject. It is essential that physicians or nurses teach proper use.. FDA approved Edex, a slightly different formulation of alprostadil, in 1997. It is less expensive than Caverject and is injected with a smaller needle. Users inject it ten minutes before sex; erections can last more than one hour.. Sometime this year, FDA will evaluate another injectable medication, Invicorp. It consists of the protein VIP and phentolamine, which help relax smooth-muscle tissue. It may be more effective than alprostadil and is not expected to cause the pain associated with Caverject and Edex.. * Transurethral therapy. A relatively new product approved in 1997, alprostadil is administered by means of a small applicator that delivers a soft, tiny, medicated pellet to the urethra [the opening at the end of the penis]. The urethra absorbs the drug and distributes it to the surrounding erectile tissues. This causes blood vessels to relax and allows the penis to fill with ...
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Erectile Dysfunction News Some males with erectile dysfunction , or ED, discover they will return to an energetic intercourse life by treating an underlying condition, equivalent to high blood pressure , or with counseling and life-style modifications. Porst H, van Ahlen H, Block T et al: Intracavernous self-injection of prostaglandin E1 in the remedy of erectile dysfunction. The period of time required for sildenafil to start working can depend upon a number of factors, from the precise response its a must to the drug to the quantity you have eaten before swallowing the tablet. Therapy of male impotence or erectile dysfunction will depend upon the cause of erectile dysfunction. Yiou R, Cunin P, de la Taille A et al: Sexual rehabilitation and penile pain related to intracavernous alprostadil after radical prostatectomy. If a persons erectile dysfunction does not respond to remedy, they might be offered alprostadil. eleven. Jardin A, Wagner G, Khoury S, et al. Recommendations of the 1st ...
Viridal 10 Duo Starter Pack contains the active ingredient Alprostadil cause blood vessels to widen by relaxing the thin layer of muscle found in the vessel wall
Alprostadil only. If the patient achieves a normal erection as confirmed by the urologist then the patient has a clearcut psychological cause and requires counselling/or psychotherapy.. He may be advised and taught self injection with papavereine for a few weeks to improve his self confidence. Later it can be discontinued. Many patients experience recovery of spontaneous erection with PIPE. However a few things about PIPE need to be mentioned. The first few injections have to be supervized by the urologist. The exact dose needed has be decided by the urologist and the details of the method of injection. The erection produced should not last for more than 45 minutes to 1 hour. If it lasts for a longer time the patient has to report immediately. Persistent erection for more than one hour is called priaprism and has to be treated immediately. Another complication is the occurrence of fibrosis i.e. a small area of hardness at the site of injection.. PIPE cannot be given to patients with bleeding ...
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Lubiprostone is useful in treating patient with irritable bowel syndrome with chronic cases of constipation. Lubiprostone will aid in propulsive movement of the gut.
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Basic Rider Optimization Training for the Segway™ Human Transporter (HT) i Series, e Series and p Series models Instructor Guide and Participant Workbook Instructor Guide and Participant Workbook © Segway LLC 2002 Rev 3.5i - January 2004 P/N 1707100001aa Page 2 of 106 Basic Rider Optimization Training for the Segway HT Important information for e Series users To reduce the risk of injury, all users of e Series models should first complete training provided by a Segway authorized trainer. The Segway HT e Series has all the same components as the Segway HT i Series, and the following additional components and features: , , , , A Front Bag Frame and Front Bag A Lower Cargo Structure Two Side Bags An electronic parking stand, called E-Stand, that enables the e Series to balance itself (park) without a rider Please follow these recommendations: , , , , , , , Charge your Segway HT for a full 12 hours before the first use. Do not let anyone power on your Segway HT e Series Segway HT or try ...
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Mineralogy and mineral chemistry data collected on unusual boninite samples (U1439C 15R-1, U1439C 25R-1) recovered during IODP Expedition 352 demonstrate highly variable mineral chemistries that suggest complex crystallization histories. The samples include early-crystallized olivines with embayed and reacted margins, some of which also show zoning (Fo87 cores; Fo77 rims), and large, euhedral pyroxene crystals, with clinoenstatite to pigeonite cores (En86 Fs12 Wo2, to En69 Fs12 Wo19), and augite rims (En43 Fs17 Wo40). Cr-rich spinels were found to be enclosed in both olivines and pyroxenes. These spinels show elevated Al2O3 and MgO contents (≈8-12%), suggesting early high pressure crystallization. Further EPMA studies of these and other Expedition 352 boninites, focused on spinel-olivine and spinel-pyroxene relationships, were conducted using the JEOL 8900R electron microprobe system at the Florida Center for Analytical Electron Microscopy (FCAEM) at Florida International University. Olivine-spinel
"Alprostadil". Drug Information Portal. U.S. National Library of Medicine. "Dinoprostone". Drug Information Portal. U.S. ... Types include: Prostaglandin E1 also known as alprostadil Prostaglandin E2 also known as dinoprostone Both types are on the ...
Alprostadil is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and supplies may ... Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when the threat of ... Prostanoids, including alprostadil, do not reduce the risk of limb amputation but may offer a slight improvement in rest-pain ... Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is ...
"Alprostadil". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 ... alprostadil). Other medication groups reported are antihypertensives, antipsychotics (e.g., chlorpromazine, clozapine), ...
"Alprostadil (PGE1) for Maintaining Ductal Patency". Fredenburg, Tyler B.; Johnson, Tiffanie R.; Cohen, Mervyn D. (2011-03-01 ...
Alprostadil: commonly known as PGE1, is a naturally occurring prostaglandin and vasodilator. Alprostadil has not been added to ...
The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded ...
Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction (impotence). They are ...
PGE1 has a role in regulation of immune system function and is used as the medicine alprostadil. Unlike AA and EPA, DGLA cannot ...
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Prostaglandin PGE1 (Alprostadil) binds G-protein linked cell surface receptors that activate adenylate cyclase to relax ...
No difference have been detected between iloprost or clinprost (prostacyclin) and alprostadil (prostaglandin analogue) for ...
Intracavernosal injections of alprostadil may be used by people for whom other treatments such as PDE5 inhibitors are ...
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Drugs such as alprostadil, a PGE-1 analog, can be used to keep a PDA open until the primary defect is corrected surgically.[ ...
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G04BD09 Trospium G04BD10 Darifenacin G04BD11 Fesoterodine G04BD12 Mirabegron G04BD13 Desfesoterodine G04BE01 Alprostadil ...
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If male patients insist that their penis is shrinking and disappearing, measurements after intracavernosal alprostadil may be ...
... alprostadil MeSH D10.251.355.255.550.250.200 - dinoprostone MeSH D10.251.355.255.550.400 - prostaglandins f MeSH D10.251. ... alprostadil MeSH D10.251.355.325.190 - capsaicin MeSH D10.251.355.325.200 - cilastatin MeSH D10.251.355.325.240 - crotonic ...
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PGE1 as alprostadil). To measure erect penis size in a clinical environment To treat egg binding in small birds The original ...
... alprostadil MeSH D23.469.050.175.725.780.200 - dinoprostone MeSH D23.469.050.175.725.790 - prostaglandins f MeSH D23.469. ...
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Alprostadil Urogenital: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Alprostadil injection should not be used more than three times per week, with at least 24 hours between uses. Alprostadil ... Your doctor may tell you not to use alprostadil.. *if you are using the alprostadil pellet, tell your doctor if you have or ... Alprostadil does not cure erectile dysfunction or increase sexual desire. Alprostadil does not prevent pregnancy or the spread ...
Alprostadil therapy for ductus-dependent congenital heart disease maintains cardiovascular function until palliative or ... Alprostadil, or prostaglandin E1 (PGE1), can be a lifesaving drug for infants born with ductus-dependent congenital heart ... Cite this: Alprostadil (PGE1) for Maintaining Ductal Patency - Medscape - Sep 01, 2000. ...
ALPROSTADIL (UNII: F5TD010360) (ALPROSTADIL - UNII:F5TD010360) ALPROSTADIL. 500 ug in 1 mL. ... No unchanged alprostadil has been found in the urine, and there is no evidence of tissue retention of alprostadil or its ... Alprostadil must be infused continuously because it is very rapidly metabolized. As much as 80% of the circulating alprostadil ... Alprostadil injection USP for intravascular infusion contains 500 micrograms alprostadil, more commonly known as prostaglandin ...
Alprostadil Urogenital Alprostadil injection and suppositories are used to treat certain types of erectile dysfunction ( ... misoprostol (Cytotec, in Arthrotec); other prostaglandins such as alprostadil (Caverject, Edex, Muse, others), carboprost ...
Alprostadil Sterile Powder for Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, ... In most animal species tested, alprostadil relaxed retractor penis and corpus cavernosum urethrae in vitro. Alprostadil also ... Infusion rates of alprostadil ranged from 5 to 50 (median, 45) nanograms/kilogram/minute, resulting in alprostadil plasma ... greater than baseline levels of endogenous alprostadil (96 picograms/milliliter). Alprostadil is bound in plasma primarily to ...
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Early postoperative administration of alprostadil injections significantly increases the recovery rate of spontaneous erections ... Purpose: This study was aimed at assessing prospectively the effect of postoperative intracavernous injections of alprostadil ... Erectile rehabilitation with intracavernous alprostadil after radical prostatectomy: refusal and dropout rates. Polito M, ... Conclusions: Early postoperative administration of alprostadil injections significantly increases the recovery rate of ...
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MUSE® (alprostadil) is a single-use, medicated transurethral system for the delivery of alprostadil to the male urethra. ... Long-term carcinogenicity studies of alprostadil have not been conducted. Alprostadil showed no evidence of mutagenicity in ... permitting alprostadil to be absorbed by the urethral mucosa. The transurethral absorption of alprostadil after MUSE ... Known hypersensitivity to alprostadil (the active medication in MUSE) •. An abnormally formed penis •. Have been advised not to ...
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How alprostadil works. Alprostadil is a prostaglandin. It relaxes the muscles around your penis and opens the blood vessels to ... Pharmacist tips for alprostadil. Alprostadil shouldnt be used more than 3 times per week and shouldnt be given more often ... Typical dosing for alprostadil. *Treatment of ED: The first injections will be done at the providers office so they can ... Only inject alprostadil into the side or base, on the lower one-third of your penis. Make sure to alternate injection sites and ...
How alprostadil works. Alprostadil is a prostaglandin. It relaxes the muscles around your penis and opens the blood vessels to ... Pharmacist tips for alprostadil. Alprostadil shouldnt be used more than 3 times per week and shouldnt be given more often ... Typical dosing for alprostadil. *Treatment of ED: The first injections will be done at the providers office so they can ... Only inject alprostadil into the side or base, on the lower one-third of your penis. Make sure to alternate injection sites and ...
Alprostadil (Prostaglandin E1). *View full drug information. Alprostadil is a strong vasodilator of all vascular beds. ...
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Alprostadil. Alprostadil is a vasodilator, prescribed for erectile dysfunction (impotence; inability to get or keep an erection ...
Alprostadil acts as a smooth muscle relaxer and maintains patency of the ductus arteriosus when a cyanotic lesion (eg, critical ... Alprostadil (Prostaglandin E1, PGE1) is used to treat ductal-dependent cyanotic congenital heart disease, which is caused by ...
Keywords: Cholesterol embolism; Corticosteroids; Alprostadil INTRODUCTION. Cholesterol embolism is a rare but serious disease ... Treatment of Cholesterol Embolism With Corticosteroids and Alprostadil. Article information. Ann Geriatr Med Res. 2019;23(1):31 ... Therefore, administration of a combination of steroids and alprostadil may be a good option for improving treatment success ... We reviewed existing reports and planned to administer high doses of corticosteroids and alprostadil. Initially, we prescribed ...
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Find information on Alprostadil (Intracavernosal, Intraurethral) - Caverject, Edex in Daviss Drug Guide including dosage, side ... "Alprostadil (intracavernosal, Intraurethral)." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2020. Daviss Drug Guide - OLD ... alprostadil (intracavernosal, intraurethral) is a topic covered in the Daviss Drug Guide. To view the entire topic, please log ... Alprostadil (intracavernosal, Intraurethral) [Internet]. In: Daviss Drug Guide. F.A. Davis Company; 2020. [cited 2022 May 28 ...
  • Another medication used to treat erectile dysfunction is alprostadil (Caverject Impulse, Edex, Muse), which is Prostaglandin E1 therapy. (healthline.com)
  • Alprostadil (Prostaglandin E1) is used primarily to keep patency of ductus arteriosus but also has a mild pulmonary vasodilatory effect. (medscape.com)
  • The most commonly used agents are alprostadil (prostaglandin E1 [PGE1]), papaverine, and phentolamine. (medscape.com)
  • Use of alprostadil, a stable prostaglandin E1 analogue, for the attenuation of rat skeletal muscle ischemia and reperfusion injury. (bvsalud.org)
  • Alprostadil (Prostaglandin E1) is a drug that has vasodilation properties and is used to treat erectile dysfunction and other medical conditions. (chromatographyonline.com)
  • The application of intraurethral prostaglandin E1 (alprostadil) can be done by a urologist or self-administered to the distal male urethra via a drug deliver system. (scireproject.com)
  • MUSE is the tablet version of Alprostadil which is used to treat impotence (erectile dysfunction). (medic8.com)
  • Muse alprostadil prix - nos vamos a casar este verano y que simplemente no se siente bien. (primeramfbank.com)
  • in Montecito was more of a backyard shindig than a muse alprostadil for sale billionaire social event, according to theo start. (primeramfbank.com)
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  • A Korean multicenter study was conducted to assess the effectiveness of transurethral alprostadil with MUSE in 334 subjects with chronic erectile dysfunction (ED) who were enrolled in 21 clinical centers. (elsevier.com)
  • MUSE (medicated transurethral system for delivery of alprostadil to the male urethra). (scireproject.com)
  • Alprostadil (Muse) intraurethral therapy involves putting a small alprostadil suppository inside your penis in the penile urethra. (windows.net)
  • Alprostadil injection is injected into the side of the penis. (adventisthealthcare.com)
  • Store alprostadil injection vials at cool room temperature. (adventisthealthcare.com)
  • washington, dc: library of congress, federal research division: alprostadil injection nhs. (primeramfbank.com)
  • To address these problems, the alprostadil liposome microsphere injection (Lipo-PGE 1 ) was originally produced by Mitsubishi Pharmaceutical Co., Ltd. in Tanabe, Japan. (dataemia.com)
  • There are two kinds of Lipo-PGE 1 s produced by different manufacturers in the hospital, namely alprostadil injection (10 μg, 93 RMB ) and alprostadil dried emulsion for injection (5 μg, 79 RMB ). (dataemia.com)
  • Our previous investigation demonstrated that the sales of Lipo-PGE 1 (88.75% alprostadil dried emulsion for injection and 11.25% alprostadil injection) ranked first among thousands of drugs in the hospital, and from 2014 to 2017, the prescription rate of Lipo-PGE 1 for inpatients in the hospital increased annually, which were 4.25%, 10.05%, 12.53%, and 13.63%, respectively. (dataemia.com)
  • Alprostadil as an injection into the penis or as a suppository (intra-urethral). (cliniquelactuel.com)
  • alprostadil (intracavernosal, intraurethral) is a topic covered in the Davis's Drug Guide . (unboundmedicine.com)
  • Intraurethral alprostadil was titrated in a stepwise fashion in the clinics from 250 to 500 or 1000 mcg based on erectile response and tolerability. (elsevier.com)
  • found that the use of intraurethral alprostadil (PGE1) was ineffective in sustaining an adequate erection, and without a penile ring to sustain any increase in penile circumference (tumescence), patients experienced hypotension from the medication. (scireproject.com)
  • This medication guide addresses only the adult male use of alprostadil in erectile disorders. (adventisthealthcare.com)
  • Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. (adventisthealthcare.com)
  • METHODS: Impotent males self-administered the Duke Health Profile before and during treatment with alprostadil for erectile dysfunction during a 19-month period. (rand.org)
  • In conclusion, transurethral alprostadil could be a suitable treatment option for patients with ED regardless of age and etiology of ED. Efficacy in an Asian population (Korea) is comparable to that reported previously in Caucasians. (elsevier.com)
  • Examples include alprostadil and phentolamine. (windows.net)
  • as safe to eat unless alprostadil alfadex wiki they have undergone long-term animal safety assessments utilizing endpoints relevant. (primeramfbank.com)
  • eluxadoline increases levels of alprostadil intracavernous/urethral by decreasing metabolism. (medscape.com)
  • alprostadil intracavernous/urethral increases effects of antithrombin alfa by pharmacodynamic synergism. (medscape.com)
  • While using alprostadil pellets, use condoms during sex if your partner is pregnant or able to get pregnant. (adventisthealthcare.com)
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  • Alprostadil relaxes blood vessels and muscles in the penis which increases blood flow, causing an erection. (adventisthealthcare.com)
  • When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears. (familywize.org)
  • Your doctor should check you every 3 months to be sure alprostadil is not causing harmful effects on your penis. (adventisthealthcare.com)
  • Eddie", and injectables like alprostadil or its tablet form placed inside the tip of the penis. (modernghana.com)
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  • Perkembangan sistem saraf bayi juga alprostadil tablet bisa maksimal dengan banyaknya konsumsi makanan yang mengandung asam folat. (primeramfbank.com)
  • Lipo-PGE 1 could accumulate in inflammatory lesions and diseased vessels due to the enhanced permeability and retention (EPR) effect of lipid microspheres, which significantly reduces the dose of alprostadil and thus minimizes toxic side effects 11 , 12 , 13 . (dataemia.com)
  • Each dose based on your health records that you are not recommended for taking alprostadil. (gors.nl)
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  • Alprostadil was expected to improve mental health primarily, and results of the study were consistent with this hypothesis. (rand.org)
  • disease than onde comprar alprostadil patients with Hodgkins disease.PubMed Becher E Tejada Noriega A Gomez R Decia R Southern. (primeramfbank.com)
  • Les variables comprenaient les données sociodémographiques, cliniques et thérapeutiques des patients pris en charge pour une urgence pénienne. (bvsalud.org)
  • Résultats : Durant cette période, 63 patients ont été pris en charge pour urgences péniennes. (bvsalud.org)
  • The effects of alprostadil on an unborn baby at conception or during pregnancy are unknown. (adventisthealthcare.com)
  • What are the possible side effects of alprostadil? (adventisthealthcare.com)
  • Some stable prostaglandin analogues such as alprostadil have been used to attenuate the deleterious effects of ischemia and reperfusion injury . (bvsalud.org)
  • Under conditions of partial skeletal muscle ischemia , alprostadil did not reduce the release of muscular enzymes , the consumption of tissue glycogen or the effects of ischemia and reperfusion on the cell membrane , characterized by lipid peroxidation . (bvsalud.org)
  • Other versions of Alprostadil include Viridal Duo . (medic8.com)
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  • that included patient and physician global assessments, pain, functional status, and an acute alprostadil zastrzyki phase. (primeramfbank.com)
  • The first group (control) received continuous intravenous infusion of saline solution and the second group (preischemia, GPI) received continuous intravenous infusion of alprostadil throughout the experiment starting 20 minutes before the aortic cross- clamping . (bvsalud.org)