AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
AlprostadilErectile DysfunctionUrethraCoitusPenisPenile ErectionSciatic NeuropathyDrug Administration RoutesVasodilator AgentsDouble-Blind MethodTreatment Outcome
Alprostadil
A potent vasodilator agent that increases peripheral blood flow.
Erectile Dysfunction
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
Urethra
A tube that transports URINE from the URINARY BLADDER to the outside of the body in both the sexes. It also has a reproductive function in the male by providing a passage for SPERM.
Coitus
The sexual union of a male and a female, a term used for human only.
Penis
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Penile Erection
The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.
Sciatic Neuropathy
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Drug Administration Routes
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Vasodilator Agents
Drugs used to cause dilation of the blood vessels.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro. (1/875)

1. The thienopyridine clopidogrel is a specific inhibitor of ADP-induced platelet aggregation ex vivo. No direct effects of clopidogrel (< or = 100 microM) on platelet aggregation in vitro have been described so far. 2. Possible in vitro antiaggregatory effects (turbidimetry) of clopidogrel were studied in human platelet-rich plasma and in washed platelets. 3. Incubation of platelet-rich plasma with clopidogrel (< or = 100 microM) for up to 8 h did not result in any inhibition of ADP (6 microM)-induced platelet aggregation. 4. Incubation of washed platelets with clopidogrel resulted in a time- (maximum effects after 30 min) and concentration-dependent (IC50 1.9+/-0.3 microM) inhibition of ADP (6 microM)-induced platelet aggregation. Clopidogrel (30 microM) did not inhibit collagen (2.5 microg ml(-1))-, U46619 (1 microM)- or thrombin (0.1 u ml(-1))-induced platelet aggregation. The inhibition of ADP-induced aggregation by clopidogrel (30 microM) was insurmountable indicating a non-equilibrium antagonism of ADP actions. The R enantiomer SR 25989 C (30 microM) was significantly less active than clopidogrel (30 microM) in inhibiting platelet aggregation (32+/-5% vs 70+/-1% inhibition, P < 0.05, n = 5). 5. In washed platelets, clopidogrel (< or = 30 microM) did not significantly reverse the inhibition of prostaglandin E1 (1 microM)-induced platelet cyclic AMP formation by ADP (6 microM). 6. The antiaggregatory effects of clopidogrel were unchanged when the compound was removed from the platelet suspension. However, platelet inhibition by clopidogrel was completely abolished when albumin (350 mg ml(-1)) was present in the test buffer. 7. It is concluded that clopidogrel specifically inhibits ADP-induced aggregation of washed platelets in vitro without hepatic bioactivation. Inhibition of ADP-induced platelet aggregation by clopidogrel in vitro occurs in the absence of measurable effects on the reversal of PGE1-stimulated cyclic AMP by ADP.  (+info)

Oxytocin-induced Ca2+ responses in human myometrial cells. (2/875)

Complex spatiotemporal changes in intracellular Ca2+ were monitored in an immortalized human myometrial cell line (PHM1-41) and first-passage human myometrial cells after oxytocin stimulation (1. 0-1000 nM). Laser cytometry revealed intracellular Ca2+ oscillations in both culture systems starting at 1.0 nM, which were followed by repetitive Ca2+ transients by 10-15 min that lasted for at least 90 min. The amplitude of the initial Ca2+ spike was dose dependent, while the frequency of Ca2+ oscillations identified by Fast Fourier Transform (FFT) tended to increase with dose. Removal of oxytocin resulted in termination of oscillations. Analysis of the sources of the Ca2+ involved in oscillations indicated that the major contribution to oscillation frequencies of +info)

Gestational regulation of granulocyte-colony stimulating factor receptor expression in the human placenta. (3/875)

A number of cytokines and their receptors are abundantly expressed at the materno-fetal interface and are thought to have a function in the regulation of placentation. Granulocyte-colony stimulating factor (G-CSF) is expressed by stromal cells in both placental tissue and maternal decidua throughout placentation. In this study, we examined the expression of placental G-CSF receptor (G-CSFR) mRNA and protein throughout gestation by ribonuclease protection assays, Western blotting, and immunohistochemistry. The major placental form of G-CSFR mRNA, corresponding to a membrane-bound form of the protein, was present in first-trimester placental tissues; levels decreased in second- and were highest in third-trimester placental tissues. Two placental G-CSFR molecules, 120 kDa and 150 kDa, were detected in first- and third-, but not second-, trimester tissues. The level of the 150-kDa G-CSFR was greater in the third- than in first-trimester samples. These differences were irrespective of whether or not the patients had received prostaglandin E1 analogues, prostaglandin E1 analogues and oxytocin, oxytocin alone, or mifepristone before labor. We demonstrated by immunohistochemistry that interstitial cytotrophoblast in first- and second-trimester decidual tissue and cytotrophoblast in term fetal membranes express G-CSFR. These data demonstrate that the expression of specific forms of placental G-CSFR is strictly cell type- and developmental stage-specific, and they suggest that G-CSFR may be important in decidual invasion of cytotrophoblast and in trophoblast function during placentation.  (+info)

Transduction mechanisms of porcine chondrocyte inorganic pyrophosphate elaboration. (4/875)

OBJECTIVE: To investigate cellular signaling mechanisms that influence chondrocyte production of inorganic pyrophosphate (PPi), which promotes calcium pyrophosphate dihydrate (CPPD) crystal deposition. METHODS: Articular chondrocyte and cartilage cultures were stimulated with protein kinase C (PKC) activator and adenyl cyclase activator. Generation of extracellular PPi was measured. RESULTS: Adenyl cyclase activation resulted in diminished pyrophosphate generation. PKC activation stimulated pyrophosphate elaboration. CONCLUSION: Two signaling pathways, cAMP and PKC, modulate generation of extracellular pyrophosphate by cartilage and chondrocytes. They are novel targets for potentially diminishing extracellular pyrophosphate elaboration that leads to CPPD crystal deposition.  (+info)

Effects of the prostanoid EP3-receptor agonists M&B 28767 and GR 63799X on infarct size caused by regional myocardial ischaemia in the anaesthetized rat. (5/875)

1. This study investigates the effects of two agonists of the prostanoid EP3-receptor (M&B 28767 and GR 63799X) on the infarct size caused by regional myocardial ischaemia and reperfusion in the anaesthetized rat. 2. One hundred and sixty-seven, male Wistar rats were anaesthetized (thiopentone, 120 mg kg(-1) i.p.), ventilated (8-10 ml kg(-1), 70 strokes min(-1), inspiratory oxygen concentration: 30%; PEEP: 1-2 mmHg) and subjected to occlusion of the left anterior descending coronary artery (LAD, for 7.5, 15, 25, 35, 45 or 60 min) followed by reperfusion (2 h). Infarct size was determined by staining of viable myocardium with a tetrazolium stain (NBT), histological evaluation by light and electron microscopy and determination of the plasma levels of cardiac troponin T. 3. M&B 28767 (0.5 microg kg(-1) min(-1), i.v., n=7) or GR 63799X (3 microg kg(-1) min(-1), i.v., n=7) caused significant reductions in infarct size from 60+/-3% (25 min ischaemia and 2 h reperfusion; saline-control, n=8) to 39+/-6 and 38+/-4% of the area at risk, without causing a significant fall in blood pressure. Pretreatment of rats with 5-hydroxydecanoate (5-HD), an inhibitor of ATP-sensitive potassium channels, attenuated the cardioprotective effects of both EP3-receptor agonists. The reduction in infarct size afforded by M&B 28767 was also abolished by glibenclamide and the protein kinase C (PKC) inhibitors staurosporine and chelerythrine. 4. Thus, M&B 28767 and GR 63799X reduce myocardial infarct size in the rat by a mechanism(s) which involves the activation of PKC and the opening of ATP-sensitive potassium channels.  (+info)

Transcranial Doppler pattern after intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere in patients with vasospasm. (6/875)

We studied the effects of intracarotid papaverine and prostaglandin E1 incorporated in lipid microsphere (Lipo-PGE1) in relation with transcranial Doppler parameters such as mean flow velocity (MFV) and pulsatile index (PI) of the proximal segment of the middle cerebral artery. Eighty patients with subarachnoid hemorrhage (SAH) were included in this study. In the case of angiographic vasospasm, papaverine at 7 mg/min with total dose below 300 mg per artery and 10-20 micrograms of Lipo-PGE1 were injected in the supraclinoid portion of the internal carotid artery. Vasospasm was improved in 24 patients (63%), however, it was unchanged in 14 patients (37%). The former patients had more favorable outcomes than the latter patients (p < 0.005). After intracarotid injection therapy, the correlation between MFV and PI was classified into three types: type 1, both MFV and PI decreased; type 2, MFV decreased but PI increased; and type 3, both MFV and PI fluctuated. The Glasgow Outcome Scale 3 months after SAH was as follows: type 1 (n = 15), good in 14 (93%) and moderate disability in one (7%); type 2 (n = 9), good in eight (89%) and vegetative state in one (11%); and type 3 (n = 14), moderate disability in five (36%), severe disability in seven (50%), and death in two (14%). Chi-square analysis showed significant differences between type 1 and type 3 (p < 0.005), and type 2 and type 3 (p < 0.005). In conclusion, intracarotid papaverine combined with Lipo-PGE1 was effective for vasospasm but type 3 patients require a different treatment protocol.  (+info)

Platelet-stimulated thrombin and PDGF are normalized by insulin and Ca2+ channel blockers. (7/875)

Coronary artery disease is accelerated in chronic spinal cord injury (SCI). Because prostacyclin (PGI2) may retard atherogenesis through its inhibitory effects on platelet function, the role of PGI2 on SCI platelets was determined. The SCI platelets were neither hypersensitive to aggregating agonists nor resistant to the inhibitory effect of PGI2, but PGI2 failed to inhibit platelet-stimulated thrombin generation and the release of platelet-derived growth factor (PDGF) in SCI. Because thrombin and PDGF are atherogenic mitogens, the generation of these mitogens was investigated. Both the release of PDGF and thrombin generation in SCI platelets were higher when compared with control (n = 12). Treatment of non-SCI platelets with 100 nM PGE1 (a stable probe of PGI2) inhibited the release of the mitogens by 90% (P < 0.001), with no effect on SCI platelets. Scatchard analysis of prostaglandin E1 (PGE1) binding showed a 70% decrease of PGI2 receptors on the SCI platelet surface. Treatment of SCI platelets with insulin or Ca2+ channel blockers restored the PGI2-receptor number and "normalized" the inhibition of PDGF release and thrombin generation by PGI2.  (+info)

Seminal plasma components stimulate interleukin-8 and interleukin-10 release. (8/875)

Human seminal plasma has potent anti-inflammatory properties which are thought to confer a survival advantage to the spermatozoa within the hostile female genital tract. In contrast, a profound pro-inflammatory leukocytosis has been observed post-coitus in animals and humans. Whether components of seminal plasma are involved in initiating this leukocytic reaction is not known. This study investigated the effect of human seminal plasma, a seminal plasma fraction and its principal constituent prostaglandins, prostaglandin E2 (PGE2) and 19-hydroxy PGE, on the release of the pro-inflammatory neutrophil chemotactic factor interleukin-8 (IL-8) and the anti-inflammatory cytokines interleukin-10 (IL-10) and secretory leukocyte protease inhibitor (SLPI). The tissues studied were non-pregnant cervical explants, peripheral blood and the monocyte cell line U937. Seminal plasma fraction (SPF) significantly (P < 0.05) stimulated release of IL-8 and inhibited release of SLPI from non-pregnant cervical explants. SPF, PGE2 and 19-hydroxy PGE significantly (P< 0.005) stimulated IL-8 release from peripheral blood and U937 cells. 19-hydroxy PGE was significantly (P< 0.005) more effective than PGE2 in stimulating IL-8 release. Seminal plasma, SPF and PGE2 significantly (P < 0.05) stimulated IL-10 release from U937 cells. 19-hydroxy PGE stimulated IL-10 release from U937 cells but this failed to reach significance. Release of IL-10 by cervical explants and SLPI by peripheral blood and U937 cells were below the detection limit of the assays employed. We suggest that the anti- and pro-inflammatory immune responses which seminal plasma induces might act in combination initially to promote sperm survival and then to facilitate their removal from the female genital tract.  (+info)

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Alprostadil (FemLife Gel) in the Treatment of Female Sexual Arousal Disorder - Full Text View - ClinicalTrials.govAlprostadil (FemLife Gel) in the Treatment of Female Sexual Arousal Disorder - Full Text View - ClinicalTrials.gov
Female sexual arousal disorder (FSAD) is a frequent finding in women in middle age and more prevalent in post-menopausal women. Topical alprostadil is currently under development for the treatment of FSAD. The purpose of this research is to determine if this formula of alprostadil is safe and effective in women with FSAD. We will be comparing alprostadil to placebo. Each participant will be treated for 1 month with active alprostadil and 1 month with placebo without knowing which they are using. This way, the investigators can compare the effects of alprostadil to the effects of an inactive topical gel.. Post-menopausal women with FSAD will be recruited. The women interested in participating in the study will first meet with investigators and answer questions to make sure they are eligible for the study and fit the diagnosis of FSAD.. Once enrolled, subjects will fill out questionnaires about their medical history, social history, and psychosocial history. They will also undergo medical ...
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Age: 54 at surgery (DOB 1955). Married: Yes (31 years). Gleason: 3+3. Surgery: Davinci on 06-25-2009, catheter out July 6, 2009. Continancy: Only some Stress wetness in first months. No pads since. PSA (post): Below .10 since surgery. Erection: 1 month : Pump was effective for intercourse but not satisfying. 3 months: Pump with Viagra, Levitra, Cialis (LVC) was better but not much. 6 months: Alprostadil (0.6cc) with pump with inconsistent results. 9 months: Alprostadil (1.0cc)with pump and LVC was better but inconsistent results. 12 months: TRiMix(0.4cc)/Pump/LVC and WOW Return of the Light Saber, life is good. 100% erection for over 2 hours, 85% for another hour or so. FUN FUN FUN. ...
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The Safety and Tolerability of Alprostadil Liposome for Injection in Healthy Adult Volunteers - Full Text View - ClinicalTrials...The Safety and Tolerability of Alprostadil Liposome for Injection in Healthy Adult Volunteers - Full Text View - ClinicalTrials...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil | OMICS...Successful Intensification of Intravenous Rheological Treatment of Phalanges Ischemia in SSc Patient Using Alprostadil | OMICS...
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Prostaglandin e1: indications, dosage and side-effects
Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth.
http://drug.report/Prostaglandin+e1/85/
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Impotence, Male - RxMed.comImpotence, Male - RxMed.com
Alprostadil (Caverject) 10-20 mg/mL; inject into the dorsolateral aspect of proximal third of the penis. Do not exceed 60 mg dose. Do not use more than 3 times a week or more than once in 24 hours. Patient to notify physician if erection lasts , 6 hours for immediate attention ...
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Caverject Impulse Side Effects: Common, Severe, Long Term - Drugs.comCaverject Impulse Side Effects: Common, Severe, Long Term - Drugs.com
Learn about the potential side effects of Caverject Impulse (alprostadil). Includes common and rare side effects information for consumers and healthcare professionals.
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Abcur English| Advanz PharmaAbcur English| Advanz Pharma
ADVANZ PHARMA Corp. Limited Announces Definitive Agreement to Acquire The Rights To A Portfolio Of Alprostadil Products From UCB S.A. For Approximately $84 ...
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PatientsLikeMe | Alprostadil report for patients like youPatientsLikeMe | Alprostadil report for patients like you
Alprostadil: Find the most comprehensive real-world treatment information on Alprostadil at PatientsLikeMe. 4 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), epilepsy, amyotrophic lateral sclerosis, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, asthma, bipolar II disorder, attention deficit/hyperactivity disorder, social anxiety disorder, high cholesterol (hypercholesterolemia), idiopathic pulmonary fibrosis, irritable bowel syndrome, psoriasis, gastroesophageal reflux disease or bipolar I disorder currently take Alprostadil.
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NEXMED TO DISCUSS P2/3 PROTOCOL FOR NEXACT® -BASED ALPROSTADIL TREATMENT FOR RAYNAUDS SYNDROME WITH THE FDA | FierceBiotechNEXMED TO DISCUSS P2/3 PROTOCOL FOR NEXACT® -BASED ALPROSTADIL TREATMENT FOR RAYNAUDS SYNDROME WITH THE FDA | FierceBiotech
NEXMED TO DISCUSS P2/3 PROTOCOL FOR NEXACT® -BASED ALPROSTADIL TREATMENT FOR RAYNAUDS SYNDROME WITH THE FDA San Diego--(BUSINESS WIRE)-- NexMed, Inc. (Nasdaq: NEXM), a specialty CRO with a
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Erectile Dysfunction Medical Studies Vitamin E Erectile Dysfunction Dosage | Low Calorie Diet Erectile Dysfunction Erectile...
An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
https://www.testosteronemuscleboost.org/are-erectile-dysfunction-curable-erectile-dysfunction-yellow-pill.html
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An alprostadil cream that patients apply into the tip of the penis (the urethral meatus, the opening that urine passes through) is currently available in the UK and Europe. It is currently under review by the U.S. Food and Drug Administration (FDA). After application of the cream, an erection occurs within five to 30 minutes, and the erection lasts one to two hours in men who respond to the cream. Doctors recommend that one use the cream for a maximum frequency of two to three times per week and no more frequent than once every 24 hours. It has essentially the same contraindications and side effects as the other formulations of alprostadil. The cream may cause vaginal burning in roughly 4% of partners. Men should not use alprostadil cream for sexual intercourse with women of childbearing potential unless a condom is used. Researchers have performed controlled trial studies to evaluate the safety and effectiveness of this drug. Overall, 52% of men reported improvement in their erections compared ...
https://www.testosteronemuscleboost.org/reasons-men-have-erectile-dysfunction-the-best-erectile-dysfunction-medicine.html
admin | Getting Past Go: New Thoughts About Human Sexuality
Doctors determine the proper dose of Caverject. It is essential that physicians or nurses teach proper use.. FDA approved Edex, a slightly different formulation of alprostadil, in 1997. It is less expensive than Caverject and is injected with a smaller needle. Users inject it ten minutes before sex; erections can last more than one hour.. Sometime this year, FDA will evaluate another injectable medication, Invicorp. It consists of the protein VIP and phentolamine, which help relax smooth-muscle tissue. It may be more effective than alprostadil and is not expected to cause the pain associated with Caverject and Edex.. * Transurethral therapy. A relatively new product approved in 1997, alprostadil is administered by means of a small applicator that delivers a soft, tiny, medicated pellet to the urethra [the opening at the end of the penis]. The urethra absorbs the drug and distributes it to the surrounding erectile tissues. This causes blood vessels to relax and allows the penis to fill with ...
http://gettingpastgo.org/author/stelladog/
AMITIZA, THE FIRST SELECTIVE CHLORIDE CHANNEL ACTIVATOR FOR THE TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATIONAMITIZA, THE FIRST SELECTIVE CHLORIDE CHANNEL ACTIVATOR FOR THE TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION
Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals North America, Inc., announced today that AMITIZA (lubiprostone), 24-mcg soft-gel capsules, approved by the U.S. Food and Drug Administration (FDA) in January 2006, is now available by prescription in pharmacies across the United States for the treatment of chronic idiopathic constipation in adults.
https://www.fdanews.com/articles/86308-amitiza-the-first-selective-chloride-channel-activator-for-the-treatment-of-chronic-idiopathic-constipation
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Viridal 10 Duo Starter Pack contains the active ingredient Alprostadil cause blood vessels to widen by relaxing the thin layer of muscle found in the vessel wall
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Impotence - Complete health care and medical information
Alprostadil only. If the patient achieves a normal erection as confirmed by the urologist then the patient has a clearcut psychological cause and requires counselling/or psychotherapy.. He may be advised and taught self injection with papavereine for a few weeks to improve his self confidence. Later it can be discontinued. Many patients experience recovery of spontaneous erection with PIPE. However a few things about PIPE need to be mentioned. The first few injections have to be supervized by the urologist. The exact dose needed has be decided by the urologist and the details of the method of injection. The erection produced should not last for more than 45 minutes to 1 hour. If it lasts for a longer time the patient has to report immediately. Persistent erection for more than one hour is called priaprism and has to be treated immediately. Another complication is the occurrence of fibrosis i.e. a small area of hardness at the site of injection.. PIPE cannot be given to patients with bleeding ...
http://www.medivisionindia.com/impotence/
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What Is Pharmacology - Lubiprostone - MedicalrealmWhat Is Pharmacology - Lubiprostone - Medicalrealm
Lubiprostone is useful in treating patient with irritable bowel syndrome with chronic cases of constipation. Lubiprostone will aid in propulsive movement of the gut.
http://www.medicalrealm.net/what-is-pharmacology---lubiprostone.html
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Basic Rider Optimization Training for the Segway™ Human Transporter (HT) i Series, e Series and p Series models Instructor Guide and Participant Workbook Instructor Guide and Participant Workbook © Segway LLC 2002 Rev 3.5i - January 2004 P/N 1707100001aa Page 2 of 106 Basic Rider Optimization Training for the Segway HT Important information for e Series users To reduce the risk of injury, all users of e Series models should first complete training provided by a Segway authorized trainer. The Segway HT e Series has all the same components as the Segway HT i Series, and the following additional components and features: , , , , A Front Bag Frame and Front Bag A Lower Cargo Structure Two Side Bags An electronic parking stand, called E-Stand, that enables the e Series to balance itself (park) without a rider Please follow these recommendations: , , , , , , , Charge your Segway HT for a full 12 hours before the first use. Do not let anyone power on your Segway HT e Series Segway HT or try ...
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Aluminum E Series heads & tubes/tails***TnC EDC-Flex Interest/Sales Thread*** - Page 2Aluminum E Series heads & tubes/tails***TnC EDC-Flex Interest/Sales Thread*** - Page 2
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High blood pressure (BP) is a well-documented risk factor for cardiovascular disease (CVD) and chronic kidney disease progression. These associations, however,
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Evidence for High Pressure and Temperature Crystallization in Boninite by Jesse Scholpp, Stephen Hill et al.Evidence for High Pressure and Temperature Crystallization in Boninite by Jesse Scholpp, Stephen Hill et al.
Mineralogy and mineral chemistry data collected on unusual boninite samples (U1439C 15R-1, U1439C 25R-1) recovered during IODP Expedition 352 demonstrate highly variable mineral chemistries that suggest complex crystallization histories. The samples include early-crystallized olivines with embayed and reacted margins, some of which also show zoning (Fo87 cores; Fo77 rims), and large, euhedral pyroxene crystals, with clinoenstatite to pigeonite cores (En86 Fs12 Wo2, to En69 Fs12 Wo19), and augite rims (En43 Fs17 Wo40). Cr-rich spinels were found to be enclosed in both olivines and pyroxenes. These spinels show elevated Al2O3 and MgO contents (≈8-12%), suggesting early high pressure crystallization. Further EPMA studies of these and other Expedition 352 boninites, focused on spinel-olivine and spinel-pyroxene relationships, were conducted using the JEOL 8900R electron microprobe system at the Florida Center for Analytical Electron Microscopy (FCAEM) at Florida International University. Olivine-spinel
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Alprostadil is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and supplies may ... Alprostadil is also used in maintaining a patent ductus arteriosus in newborns. This is primarily useful when the threat of ... Prostanoids, including alprostadil, do not reduce the risk of limb amputation but may offer a slight improvement in rest-pain ... Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection is ...
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"Alprostadil". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 ... alprostadil). Other medication groups reported are antihypertensives, antipsychotics (e.g., chlorpromazine, clozapine), ...
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Alprostadil: commonly known as PGE1, is a naturally occurring prostaglandin and vasodilator. Alprostadil has not been added to ...
https://en.wikipedia.org/wiki/Uterotonic
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The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded ...
https://en.wikipedia.org/wiki/Trimix_(drug)
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Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction (impotence). They are ...
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PGE1 has a role in regulation of immune system function and is used as the medicine alprostadil. Unlike AA and EPA, DGLA cannot ...
https://en.wikipedia.org/wiki/Gamma-Linolenic_acid
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... alprostadil which keeps the ductus arteriosus open. Cardiac arrest occurs when the heart stops working and blood stops moving ...
https://en.wikipedia.org/wiki/Pediatric_advanced_life_support
Portopulmonary hypertensionPortopulmonary hypertension
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https://en.wikipedia.org/wiki/Portopulmonary_hypertension
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Intracavernosal injections of alprostadil may be used by people for whom other treatments such as PDE5 inhibitors are ...
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... hydrochloride is a functional inactive excipient currently used in the topical drug Vitaros, an alprostadil vasodilator ...
https://en.wikipedia.org/wiki/DDAIP
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https://en.wikipedia.org/wiki/Patent_ductus_arteriosus
Sexual medicineSexual medicine
... intracavernosal injection or intraurethral administration of alprostadil (prostaglandin E1), and surgery if necessary. ...
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Hypodermic needleHypodermic needle
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ATC code G04ATC code G04
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Koro (medicine)Koro (medicine)
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List of MeSH codes (D10)List of MeSH codes (D10)
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Self-microemulsifying drug delivery systemSelf-microemulsifying drug delivery system
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ProstaglandinProstaglandin
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List of MeSH codes (D23)List of MeSH codes (D23)
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C20H34O5C20H34O5
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Alprostadil (PGE1) for Maintaining Ductal PatencyAlprostadil (PGE1) for Maintaining Ductal Patency
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Edex1
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Prostaglandin E15
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  • The most commonly used agents are alprostadil (prostaglandin E1 [PGE1]), papaverine, and phentolamine. (medscape.com)
  • Use of alprostadil, a stable prostaglandin E1 analogue, for the attenuation of rat skeletal muscle ischemia and reperfusion injury. (bvsalud.org)
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  • The application of intraurethral prostaglandin E1 (alprostadil) can be done by a urologist or self-administered to the distal male urethra via a drug deliver system. (scireproject.com)
MUSE7
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  • A Korean multicenter study was conducted to assess the effectiveness of transurethral alprostadil with MUSE in 334 subjects with chronic erectile dysfunction (ED) who were enrolled in 21 clinical centers. (elsevier.com)
  • MUSE (medicated transurethral system for delivery of alprostadil to the male urethra). (scireproject.com)
  • Alprostadil (Muse) intraurethral therapy involves putting a small alprostadil suppository inside your penis in the penile urethra. (windows.net)
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  • Alprostadil as an injection into the penis or as a suppository (intra-urethral). (cliniquelactuel.com)
Intraurethral3
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  • Intraurethral alprostadil was titrated in a stepwise fashion in the clinics from 250 to 500 or 1000 mcg based on erectile response and tolerability. (elsevier.com)
  • found that the use of intraurethral alprostadil (PGE1) was ineffective in sustaining an adequate erection, and without a penile ring to sustain any increase in penile circumference (tumescence), patients experienced hypotension from the medication. (scireproject.com)
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  • Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. (adventisthealthcare.com)
  • METHODS: Impotent males self-administered the Duke Health Profile before and during treatment with alprostadil for erectile dysfunction during a 19-month period. (rand.org)
Transurethral1
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Erection2
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  • When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears. (familywize.org)
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Dose2
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