Alprazolam
Anti-Anxiety Agents
Lorazepam
Benzodiazepines
Diazepam
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
A double-peak phenomenon in the pharmacokinetics of alprazolam after oral administration. (1/117)
The pharmacokinetics of alprazolam (ALP) after i.v. and p.o. administration in rats were characterized. ALP decayed biexponentially after the i.v. dose (1.25 mg/kg), but the concentration-time profiles after the p.o. doses (7 and 12.5 mg/kg) exhibited a double-peak phenomenon. The presence of two peaks was confirmed by statistical analysis of the serum concentration data of ALP, as well as by observed double peaks in the serum concentration-time profiles of the two active metabolites (alpha-hydroxyalprazolam and 4-hydroxyalprazolam). An absorption model incorporating a delay site is proposed to describe the data, and the absolute oral bioavailability is estimated to be about 30%. The two peaks were approximately 80 to 115 min apart, and there was a delay in the absorption of close to 80% of oral ALP, regardless of dose. We hypothesize that the mechanism underlying the double-peak phenomenon is due to reduction in gastric motility caused by the muscle relaxant effect of ALP. This hypothesis is supported by the observed longer delay in the appearance of the second peak at the higher p.o. dose. Enterohepatic recycling is precluded from being the underlying mechanism, because of the presence of double peaks after the p.o. doses but not after the i.v. dose. This is the first reported case of double peaks for oral ALP, and this phenomenon has not been reported for other benzodiazepines. The double-peak phenomenon caused by the hypothesized mechanism may have important therapeutic and drug interaction implications, especially because benzodiazepines are commonly coadministered with other drugs. (+info)Quantitation of alprazolam and alpha-hydroxyalprazolam in human plasma using liquid chromatography electrospray ionization MS-MS. (2/117)
A sensitive and specific electrospray ionization high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method has been developed for the quantitative determination of alprazolam (AL) and alpha-hydroxyalprazolam (OH-AL) in plasma. After the addition of deuterium labeled internal standards of AL and OH-AL, plasma samples were buffered to alkaline pH and extracted with toluene/methylene chloride (7:3). Dried extract residues were reconstituted in HPLC mobile phase and injected onto a reversed-phase C18 HPLC column. The analytes were eluted isocratically at a flow rate of 250 microL/min using a solvent composed of methanol and water (60:40) containing 0.1% formic acid. The analyses were performed using selected reaction monitoring. The assay was sensitive to 0.05 ng/mL for both the parent drug and metabolite and linear to 50 ng/mL. The intra-assay percent coefficients of variation (%CV) for AL at 2, 5, and 20 ng/mL were all < or = 5.6. At these concentrations, and all OH-AL intra-assay %CVs were < or = 8.4. The interassay variabilities for AL were 11.8%CV, 8.7%CV, and 8.7%CV at 2.0, 5.0, and 20.0 ng/mL, respectively. The OH-AL interassay variabilities were 9.6%CV, 9.2%CV, and 7.8%CV at the same concentrations, respectively. The assay accuracy was less than or equal to +/- 6.6% for both analytes at the three concentrations. The method was used to quantitate AL and OH-AL in plasma samples collected from 10 subjects who were administered a 1-mg oral dose of AL. The mean AL concentration peaked at 11.5 ng/mL 1 h after the dose and AL was detectable for 48 h. The mean OH-AL concentration peaked at 0.18 ng/mL 4 h after the dose and was undetectable by 36 h. Hydrolysis of the plasma samples had little effect on the detected AL concentrations but increased OH-AL concentrations substantially. Plasma/blood ratios for AL and OH-AL exceeded 1 in the study samples. (+info)Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. (3/117)
In view of the substantial preclinical evidence that supports a seminal role of central corticotropin-releasing factor (CRF) neuronal systems in the physiology and pathophysiology of stress and anxiety, it is reasonable to suggest that the anxiolytic properties of benzodiazepines are mediated, at least in part, via regulation of CRFergic function. To begin to test this complex hypothesis, we examined the effects of acute and chronic administration of the triazolobenzodiazepine agonist alprazolam on CRF peptide concentrations, receptor-binding density, and mRNA expression in the CNS. Additionally, we measured mRNA expression for urocortin, a recently discovered neuropeptide that is generally considered to be a second endogenous ligand for CRF receptors. Both acute and chronic alprazolam administration was found to decrease CRF concentrations within the locus coeruleus. Furthermore, chronic alprazolam decreased basal activity of the hypothalamic-pituitary-adrenal axis, CRF mRNA expression in the central nucleus of the amygdala, and CRF(1) mRNA expression and receptor binding in the basolateral amygdala. In marked contrast, urocortin mRNA expression in the Edinger-Westphal nucleus and CRF(2A) receptor binding in the lateral septum and ventromedial hypothalamus were increased. Similar findings of an inverse relationship between the CRF(1) and CRF(2A) receptor systems have been reported in an anxiety model based on adverse early-life experience, suggesting the intriguing possibility that CRF neuronal systems may be comprised of two separate, but interrelated, subdivisions that can be coordinately and inversely regulated by stress, anxiety, or anxiolytic drugs. (+info)Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes. (4/117)
To study age-related changes in drug metabolism, we examined the in vitro biotransformation of midazolam (MDZ), a human cytochrome P-450 (CYP) 3A substrate, using liver microsomes from three age groups of male CD-1 mice ranging from 6 weeks to 2 years old. MDZ was metabolized to two major products, alpha-OH- and 4-OH-MDZ, which were quantified by HPLC. For both metabolites, V(max) values were reduced in old livers (P <.05), while K(m) values did not change with age. The net intrinsic clearance (the sum of V(max)/K(m) for both pathways) also was reduced in the old animals (P <.05). The capacity of ketoconazole, a CYP3A inhibitor in humans, to inhibit the biotransformation of MDZ and of alprazolam, another human CYP3A substrate, did not differ significantly with age. At 100 microM alprazolam, 0.5 microM ketoconazole inhibited metabolite formation by >80%. At 30 microM MDZ, 2.5 microM ketoconazole impaired 4-OH-MDZ formation by 88%, whereas it reduced alpha-OH-MDZ formation by only 46%. Immunoinhibition studies with polyclonal anti-rat CYP3A1/2 and CYP2C11 antibodies confirmed that 4-OH-MDZ formation was largely CYP3A-dependent, while alpha-OH-MDZ formation was mediated by CYP3A and -2C isoforms. Western blot analysis revealed decreased microsomal content of CYP3A in old livers. Net intrinsic clearance of MDZ was correlated with total CYP3A content (P <.001). These results demonstrate a reduction in MDZ biotransformation in old male mice, which may be attributable, in part, to decreased CYP3A content in old livers. Changes in expression and activity of CYP2C isoforms also may contribute to age-related changes in MDZ biotransformation, but this requires more investigation. (+info)Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance. (5/117)
The partial allosteric modulators (PAMs) of gamma-aminobutyric acid-gated Cl(-) current intensities at gamma-aminobutyric acid type A receptors have high affinity but low intrinsic efficacy on benzodiazepine recognition sites. Unlike the full allosteric modulators (FAM), like alprazolam, triazolam, and diazepam, PAMs are virtually devoid of unwanted side effects, including tolerance. Imidazenil (IMD) is a PAM that elicits potent anxiolytic and anticonvulsant actions in rodents and nonhuman primates and retains its anticonvulsant and anxiolytic effects, even in rodents that are tolerant to FAMs. IMD antagonizes the side effects of FAMs in rodents and nonhuman primates. Using patas monkeys and a multiple schedule with repeated acquisition and performance of chain responses, we report that IMD administration for 17 days antagonized without showing tolerance ALP-induced disruption of acquisition. (+info)A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. (6/117)
The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant agonist at the ORL1 receptor are reported herein. This low molecular weight compound [(1S,3aS)-8- (2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza- spiro[4. 5]decan-4-one] has high affinity for recombinant human ORL1 receptors and has 100-fold selectivity for ORL1 over other members of the opioid receptor family. It is a full agonist at these receptors and elicits dose-dependent anxiolytic-like effects in a set of validated models of distinct types of anxiety states in the rat (i.e., elevated plus-maze, fear-potentiated startle, and operant conflict). When given systemically, the compound has an efficacy and potency comparable to those of a benzodiazepine anxiolytic such as alprazolam or diazepam. However, this compound is differentiated from a classical benzodiazepine anxiolytic by a lack of efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). No significant change in intracranial self-stimulation performance and pain reactivity was observed in this dose range. Higher doses of this compound (>/=10 mg/kg) induced disruption in rat behavior. These data confirm the notable anxiolytic-like effects observed at low doses with the orphanin FQ/nociceptin neuropeptide given locally into the brain and support a role for orphanin FQ/nociceptin in adaptive behavioral fear responses to stress. (+info)Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. (7/117)
Assuming complete hepatic substrate metabolism and system linearity, quantitative effects of in vivo competitive inhibition are investigated. Following oral administration of a substrate in the presence of a competitive inhibitor, determination of the inhibition constant (Ki) is possible when plasma concentration-time profiles of both substrate and inhibitor are available. When triazolam is the P450 3A4 substrate and ketoconazole the competitive inhibitor, Ki approximately 1.2 microg/mL in humans. The effects of competitive inhibition can be divided into two components: first-pass hepatic metabolism and systemic metabolism. For drugs with high hepatic extraction ratios, the impact of competitive inhibition on hepatic first-pass metabolism can be particularly dramatic. For example, human terfenadine hepatic extraction goes from 95% in the absence of a competitive inhibitor to 35% in the presence of one (ketoconazole, 200 mg po Q 12 h dosed to steady-state). First-pass extraction therefore goes from 5% in the absence of the inhibitor to 65% in its presence. The combined effect on first-pass and systemic metabolism produces an approximate 37 fold increase in terfenadine area under the plasma concentration-time curve. Assuming intact drug is active and/or toxic, development of metabolized drugs with extensive first-pass metabolism should be avoided if possible, since inhibition of metabolism may lead to profound increases in exposure. (+info)Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. (8/117)
The purpose of this study was to evaluate the effects of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), on gamma-aminobutyric acid(A) receptors in vitro and to define its anxiolytic-like effects and side effect profile in vivo. Co 2-6749 fully inhibited [(35)S]t-butylbicyclophosphorothionate binding in rat brain cortical membranes with an IC(50) value of 230 nM and in human gamma-aminobutyric acid(A) receptor subunit combinations of alpha1beta2gamma2L, alpha2beta2gamma2L, alpha3beta2gamma2L, alpha4beta3gamma2L, alpha5beta2gamma2L, and alpha6beta3gamma2L receptors (IC(50) values of 200, 200, 96, 2300, 210, and 2000 nM). Rats were trained in a Geller-Seifter operant conflict paradigm. Co 2-6749 caused a dose-related increase in punished responding with a minimum effective dose of 1.6 mg/kg, p.o., a wide therapeutic index relative to a decrease in unpunished responding and relative to ataxia, and no tolerance. Additionally, ethanol caused less than a 2-fold shift to the left in the dose-response function of Co 2-6749 in the rotorod procedure in rats. In a pigeon conflict paradigm, punished responding was maximally increased to 784% of vehicle control by 30 mg/kg, p.o., with a 2-h duration and no effect on unpunished responding at this dose. Similarly, punished responding in squirrel monkeys was maximally increased to 1774% of control by 10 mg/kg, p.o., with no effect on unpunished responding at this dose. With robust anxiolytic-like activity across species, a large separation between anxiolytic-like effects and sedation/ataxia, a minimal interaction with ethanol, a lack of tolerance, and apparent oral bioavailability, Co 2-6749 makes an ideal candidate for development as a novel anxiolytic drug. (+info)Alprazolam is a benzodiazepine medication used to treat anxiety disorders and panic disorder.
Alprazolam is a medication that belongs to a class of drugs called benzodiazepines. It is primarily used to treat anxiety disorders, panic disorders, and symptoms of anxiety associated with depression. Alprazolam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to reduce feelings of anxiety and tension. Alprazolam is available in both immediate-release and extended-release forms, and it is typically taken orally. The immediate-release form is usually taken as needed to treat symptoms of anxiety or panic, while the extended-release form is taken once a day to provide continuous relief. While alprazolam can be effective in treating anxiety disorders, it can also be habit-forming and may cause dependence if used for extended periods of time. As such, it is typically prescribed for short-term use only, and patients are closely monitored for signs of dependence or withdrawal. Additionally, alprazolam can interact with other medications and may cause drowsiness, dizziness, and other side effects.
Anti-anxiety agents are medications used to treat anxiety disorders and symptoms such as excessive worry, nervousness, and restlessness.
Anti-anxiety agents, also known as anxiolytics, are medications that are used to treat anxiety disorders. These disorders are characterized by excessive and persistent feelings of worry, fear, and unease that can interfere with daily activities and cause significant distress. Anti-anxiety agents work by altering the levels of certain chemicals in the brain, such as serotonin and gamma-aminobutyric acid (GABA), which play a role in regulating mood and anxiety. They can be classified into several categories, including benzodiazepines, non-benzodiazepine sedatives, buspirone, and selective serotonin reuptake inhibitors (SSRIs). Benzodiazepines are the most commonly prescribed anti-anxiety agents and are effective in reducing symptoms of anxiety and panic attacks. However, they can be habit-forming and may cause side effects such as drowsiness, dizziness, and memory impairment. Non-benzodiazepine sedatives, such as zolpidem and zaleplon, are also effective in treating anxiety and insomnia but have a lower risk of dependence and withdrawal symptoms compared to benzodiazepines. Buspirone is a non-sedating anti-anxiety agent that works by increasing the levels of GABA in the brain. It is often used to treat generalized anxiety disorder and is less likely to cause side effects than benzodiazepines. SSRIs, such as fluoxetine and sertraline, are primarily used to treat depression but can also be effective in treating anxiety disorders. They work by increasing the levels of serotonin in the brain and may take several weeks to start working. It is important to note that anti-anxiety agents should only be used under the guidance of a healthcare professional and should not be used as a substitute for therapy or other forms of treatment for anxiety disorders.
Lorazepam is a benzodiazepine medication used to treat anxiety, insomnia, and seizures.
Lorazepam is a medication that belongs to a class of drugs called benzodiazepines. It is primarily used to treat anxiety disorders, panic attacks, and symptoms of alcohol withdrawal. Lorazepam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which helps to calm the nervous system and reduce anxiety. Lorazepam is available in various forms, including tablets, capsules, and injectable solutions. It is typically prescribed for short-term use, as prolonged use can lead to dependence and withdrawal symptoms. The dosage and duration of treatment will depend on the individual's condition and response to the medication. Common side effects of lorazepam include drowsiness, dizziness, confusion, and impaired coordination. More serious side effects may include allergic reactions, breathing difficulties, and an increased risk of falls and accidents. It is important to follow the instructions of a healthcare provider when taking lorazepam and to report any adverse effects immediately.
Benzodiazepines are a class of psychoactive drugs that are commonly used as sedatives, anxiolytics, and muscle relaxants in the medical field.
Benzodiazepines are a class of psychoactive drugs that are commonly used as sedatives, hypnotics, and anxiolytics in the medical field. They work by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to calm the brain and reduce anxiety, fear, and tension. Benzodiazepines are often prescribed to treat a variety of conditions, including anxiety disorders, insomnia, muscle spasms, seizures, and alcohol withdrawal. They are generally considered safe and effective when used as directed, but they can also be habit-forming and may cause side effects such as drowsiness, dizziness, confusion, memory problems, and impaired coordination. Long-term use of benzodiazepines can also lead to physical dependence and withdrawal symptoms when the medication is stopped abruptly. Therefore, it is important to use these drugs only as directed by a healthcare professional and to follow a gradual tapering schedule when discontinuing their use.
Diazepam is a benzodiazepine medication used to treat anxiety, seizures, and muscle spasms.
Diazepam is a medication that belongs to a class of drugs called benzodiazepines. It is primarily used to treat a variety of conditions, including anxiety disorders, panic attacks, muscle spasms, and seizures. Diazepam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA), which helps to calm the brain and reduce anxiety and muscle tension. Diazepam is available in various forms, including tablets, capsules, injectable solutions, and intravenous infusions. It is usually taken orally, although it can also be given intravenously or intramuscularly in certain situations. Diazepam can be habit-forming and can cause dependence if used for extended periods of time or in high doses. It can also cause side effects, including drowsiness, dizziness, confusion, and impaired coordination. As with any medication, it is important to use diazepam only as directed by a healthcare professional and to avoid using it for longer than necessary.
Tetragastrin is a hormone produced by the stomach that stimulates the release of digestive enzymes and acid.
Tetragastrin is a hormone that is produced by the stomach. It is a peptide hormone that is composed of four amino acids: glutamic acid, aspartic acid, alanine, and glycine. Tetragastrin is involved in the regulation of gastric acid secretion and has been shown to stimulate the production of hydrochloric acid in the stomach. It is also thought to play a role in the regulation of appetite and food intake. In the medical field, tetragastrin is sometimes used as a diagnostic tool to help diagnose conditions that affect gastric acid secretion, such as Zollinger-Ellison syndrome.
Alprazolam
... is taken orally, and is absorbed well - 80% of alprazolam binds to proteins in the serum (the majority binding to ... In Ireland, alprazolam is a Schedule 4 medicine. In Sweden, alprazolam is a prescription drug in List IV (Schedule 4) under the ... The activity of alprazolam in the central nervous system is dose dependent.[medical citation needed] Alprazolam is classed as a ... Alprazolam is effective in the relief of moderate to severe anxiety and panic attacks. Alprazolam is not recommended in ...
Alprazolam triazolobenzophenone
At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back ... Alprazolam triazolobenzophenone is a chemical compound which can be both a synthetic precursor and a prodrug for the ... A series of related acyl derivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam, but were ... "Sequentially labile water-soluble prodrugs of alprazolam". Journal of Medicinal Chemistry. 29 (8): 1346-50. doi:10.1021/ ...
Effects of long-term benzodiazepine use
A study of alprazolam found that 8 weeks administration of alprazolam resulted in deficits that were detectable after several ... A study found that of 42 patients treated with alprazolam, up to a third of long-term users of the benzodiazepine drug ... 6 October 2006). "Alprazolam". Meyler's Side Effects of Drugs 15E : The International Encyclopedia of Adverse Drug Reactions ... Darke S, Torok M, Duflou J (May 2014). "Circumstances and toxicology of sudden or unnatural deaths involving alprazolam". Drug ...
Benzodiazepine use disorder
"DB00404 (Alprazolam)". Canada: DrugBank. 26 August 2008. Bergman, U.; Dahl-Puustinen, M. L. (1989). "Use of prescription ... Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse ... Bromazepam has shown itself to be at least as effective as alprazolam as anxiolytic, and a superior sedative. The Central ... Evans, S. M.; Levin, F. R.; Fischman, M. W. (June 2000). "Increased sensitivity to alprazolam in females with a paternal ...
Ahmed Okasha
Carbamazepine versus alprazolam. An augmenting therapy for resistant schizophrenia. Read at the Regional WPA Symposium, ...
Neurosis
The highly addictive benzodiazepine alprazolam (Xanax) was approved for medical use in the United States in 1981, (having been ... American Society of Health-System Pharmacists (13 November 2017). "Alprazolam Monograph for Professionals". Drugs.com. Archived ...
Xanny (song)
The title is a reference to the drug Alprazolam, sold under the brand name Xanax. It is the most prescribed benzodiazepine- ... Ait-Daoud, Nassima; Hamby, Allan Scott; Sharma, Sana; Blevins, Derek (2018). "A Review of Alprazolam Use, Misuse, and ... Greenblatt, David J.; Wright, C. Eugene (June 1, 1993). "Clinical Pharmacokinetics of Alprazolam". Clinical Pharmacokinetics. ...
Allopregnanolone
Warner MD, Peabody CA, Whiteford HA, Hollister LE (April 1988). "Alprazolam as an antidepressant". The Journal of Clinical ... Srisurapanont M, Boonyanaruthee V (March 1997). "Alprazolam and standard antidepressants in the treatment of depression: a meta ... It can produce euphoria to a degree similar to that of alprazolam (3-13% at infusion doses of 90-270 μg over a one-hour period ... although alprazolam has historically been prescribed for depression. Neurosteroid GABAA receptor PAMs are known to interact ...
Fluvoxamine
Using fluvoxamine and alprazolam together can increase alprazolam plasma concentrations. If alprazolam is coadministered with ... Alprazolam, carbamazepine, trifluoperazine, and tranylcypromine. Arch Gen Psychiatry. 1988 Feb;45(2):111-9. doi: 10.1001/ ... The plasma levels of oxidatively metabolized benzodiazepines (e.g., triazolam, midazolam, alprazolam and diazepam) are likely ... CYP3A4 (moderately) which metabolizes alprazolam, aripiprazole, clozapine, haloperidol, quetiapine, pimozide, ziprasidone, etc ...
Tom Petty
... temazepam and alprazolam (both sedatives); and citalopram (an antidepressant). In a statement on his website, Petty's wife and ...
Adrenergic storm
... alprazolam and propranolol; alprazolam weakly agonizes dopamine receptors and causes catecholamine release while propranolol ...
Misuse of Drugs Act 1975
... alprazolam, lorazepam, nitrazepam, etc.) Benzylpiperazine (BZP) Cannabis (plant, leaf, fruit or seeds) Codeine ^Note 1 : ...
Kermit Gosnell
... more than 400,000 pills containing alprazolam; and more than 19,000 ounces of cough syrup containing codeine. Gosnell's lawyer ...
Nonbenzodiazepine
"Seizures following the withdrawal of alprazolam". The Journal of Nervous and Mental Disease. 174 (1): 50-2. doi:10.1097/ ...
Benzodiazepine withdrawal syndrome
A clinical trial of patients taking the benzodiazepine alprazolam for as short as eight weeks triggered protracted symptoms of ... Haque, W; Watson, DJ; Bryant, SG (1990). "Death following suspected alprazolam withdrawal seizures: A case report". Texas ... Benzodiazepines with a half-life of less than 24 hours include alprazolam, bromazepam, brotizolam, flunitrazepam, loprazolam, ... Pecknold, J.C. (1993). "Discontinuation reactions to alprazolam in panic disorder". Journal of Psychiatric Research. 27: 155- ...
Benzodiazepine overdose
Wolf BC, Lavezzi WA, Sullivan LM, Middleberg RA, Flannagan LM (March 2005). "Alprazolam-related deaths in Palm Beach County". ... Isbister GK, O'Regan L, Sibbritt D, Whyte IM (July 2004). "Alprazolam is relatively more toxic than other benzodiazepines in ... Rogers WO, Hall MA, Brissie RM, Robinson CA (January 1997). "Detection of alprazolam in three cases of methadone/benzodiazepine ... An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most ...
Separation anxiety in dogs
Benzodiazepines, such as alprazolam, are anxiolytic medications. Benzodiazepines are beneficial in the treatment of stimuli- ... alprazolam, and behavior modification for treatment of storm phobia in dogs". Journal of the American Veterinary Medical ... alprazolam, and behavior modification for treatment of storm phobia in dogs". Journal of the American Veterinary Medical ... that 30 out of the 32 canines involved in the study had reductions in anxious behaviors after being treated with alprazolam. ...
List of Schedule IV controlled substances (U.S.)
Mullen, Jr., Francis M. (November 12, 1981). "Schedules of Controlled Substsnces; Placement of Alprazolam in Schedule IV" (PDF ...
Flunitrazepam
"Prescribing of Benzodiazepines Alprazolam and Flunitrazepam" (PDF). Pharmaceutical Services Branch. New South Wales Health. ... Prescription forgeries for other benzodiazepines marketed in Sweden (alprazolam, clonazepam, lorazepam, clobazam, and ...
Mood disorder
Benzodiazepines, such as alprazolam, clonazepam, lorazepam and diazepam, can cause both depression and mania. Benzodiazepines ... "Discontinuation of Alprazolam Treatment in Panic Patients". Am J Psychiatry. 144 (3): 303-8. doi:10.1176/ajp.144.3.303. PMID ... "Emergence of depressive symptoms in patients receiving alprazolam for panic disorder". Am J Psychiatry. 144 (5): 664-665. doi: ...
Benzodiazepine
"Alprazolam - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 2019-08-28. "Midazolam Injection" (PDF ... Matar MA, Zohar J, Kaplan Z, Cohen H (April 2009). "Alprazolam treatment immediately after stress exposure interferes with the ... Examples are alprazolam, estazolam, flunitrazepam, clonazepam, lormetazepam, lorazepam, nitrazepam, and temazepam. Long-acting ... Wilhelm FH, Roth WT (September 1997). "Acute and delayed effects of alprazolam on flight phobics during exposure". Behaviour ...
Drugs and Cosmetics Rules, 1945
Examples: androgenic, anabolic, oestrogenic and progestational substances; Alprazolam (Xanax), Hepatitis B vaccine, Ibuprofen, ...
List of psychotropic medications
Xanax (alprazolam) - a benzodiazepine used to treat anxiety. Zoloft (sertraline) - an antidepressant of the SSRI class. ...
Xanax (disambiguation)
Xanax is the trade name of the drug Alprazolam. Xanax may also refer to: Xanax (band), a Serbian musical group Xanax the ...
Caffeine-induced anxiety disorder
"Caffeine augments Alprazolam induced cytotoxicity in human cell lines". Toxicology in Vitro. 23 (6): 1100-1109. doi:10.1016/j. ... For individuals being treated with benzodiazepines such as alprazolam (Xanax) for anxiety disorders, even small amounts of ...
Clark James Gable
He had overdosed on "illicit fentanyl, oxycodone, and alprazolam". "The Birth of Clark James Gable". CaliforniaBirthIndex.org ...
William Shell
Alprazolam 0.5 mg and GABAdone); Gaboxetine Convenience Pack (Fluoxetine 10 mg and GABAdone); Trazamine Convenience Pack ( ...
List of designer drugs
September 2022). "The alprazolam analogue 4'-chloro deschloroalprazolam identified in seized capsules". Drug Testing and ...
Abecarnil
Jung ME, Wallis CJ, Gatch MB, Lal H (June 2000). "Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol ... Pinna G, Galici R, Schneider HH, Stephens DN, Turski L (March 1997). "Alprazolam dependence prevented by substituting with the ...
Date rape drug
"Undercover Colors SipChip: detects Flunitrazepam, Alprazolam, Diazepam, Midazolam, Oxazepam, Temazepam". Undercover Colors. ...
Alprazolam: MedlinePlus Drug Information
Alprazolam: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before taking alprazolam,. *tell your doctor and pharmacist if you are allergic to alprazolam, chlordiazepoxide (Librium, in ... Alprazolam may harm the fetus. If you become pregnant while taking alprazolam, call your doctor. ... Alprazolam may be habit forming. Do not take a larger dose, take it more often, or for a longer time than your doctor tells you ...
Sertraline ( Zoloft ), Amphetamine and Alprazolam (Xanax)
alprazolam, and dextroamphetamine in humans by. Zawertailo LA, Busto U, Kaplan HL, Sellers EM. Mental Health Unit,. Addiction ... Alprazolam (Xanax). New antidepresants. Long-term sertraline. Sertraline and noradrenaline. Sertraline and personality ... Both alprazolam and dextroamphetamine were distinguishable from placebo on most measures, but sertraline produced effects ... The subjective and behavioral effects of sertraline were studied and compared with the effects of alprazolam and ...
Alprazolam | Where Can I Buy Amoxicillin Online - Maroon 5
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BenzodiazepinesMetabolitesTriazolamDoseTriazoloBioavailabilityOrder AlprazolamAttacksExtended-release tabletXanaxEffects of alprazolamAnxiety disordersMedicationsDosesPOWDERPillsTabletsEliminationHumansDrugDiazepamGenerallyPanic disorderTreatmentOccurAdultsSymptomsPharmacyTreatMedicalCommonSimilarMentalQuantityExperience
Benzodiazepines4
- Alprazolam is in a class of medications called benzodiazepines. (medlineplus.gov)
- Like other triazolo benzodiazepines such as triazolam, alprazolam may have significant drug interactions involving the hepatic cytochrome P-450 3A4 isoenzyme. (medswow.com)
- Unlike other benzodiazepines, alprazolam may also have some antidepressant activity, although clinical evidence of this is lacking. (medswow.com)
- With wide safety margins and few contraindications, the benzodiazepines most commonly used by dentists are diazepam, as a mild sedation-inducing anxiolytic, midazolam, to induce sleep and amnesia, and alprazolam, lorazepam, and triazolam, each with their appropriate properties and preferred dosages. (bvsalud.org)
Metabolites5
- The pharmacokinetics of alprazolam and two of its major active metabolites (4-hydroxyalprazolam and α-hydroxyalprazolam) are linear, and concentrations are proportional up to the recommended maximum daily dose of 10 mg given once daily. (nih.gov)
- Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to two major metabolites in the plasma: 4-hydroxyalprazolam and α-hydroxyalprazolam. (nih.gov)
- The pharmacokinetic parameters at steady-state for the two hydroxylated metabolites of alprazolam (4-hydroxyalprazolam and α-hydroxyalprazolam) were similar for alprazolam and alprazolam extended-release tablets, indicating that the metabolism of alprazolam is not affected by absorption rate. (nih.gov)
- Unlike chlordiazepoxide, clorazepate, and prazepam, alprazolam has a shorter half-life and metabolites with minimal activity. (medswow.com)
- Route of elimination: Alprazolam and its metabolites are excreted primarily in the urine. (medswow.com)
Triazolam1
- o alprazolam, o lorazepam e o triazolam, cada qual com suas devidas propriedades e posologias de eleição. (bvsalud.org)
Dose3
- Your doctor probably will decrease your alprazolam dose gradually. (medlineplus.gov)
- Multiple dose studies indicate that the metabolism and elimination of alprazolam are similar for the immediate-release and the extended-release products. (nih.gov)
- The primary endpoint of the study was the change in standardized photosensitivity range (SPR) in participants receiving each dose of Staccato alprazolam. (drugdiscoverynews.com)
Triazolo2
Bioavailability2
- The bioavailability and pharmacokinetics of alprazolam following administration of alprazolam extended-release tablets are similar to that for alprazolam tablets, with the exception of a slower rate of absorption. (nih.gov)
- Food has a significant influence on the bioavailability of alprazolam extended-release tablets. (nih.gov)
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Attacks3
- Alprazolam is used to treat anxiety disorders and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks). (medlineplus.gov)
- However, Alprazolam can effectively deal with signs of anxiety attacks and panic disorders by relaxing the areas of your brain whose hyperactivity may be the root cause of such occurrences. (alprazolam.org)
- Alprazolam is a popular and widely used short-acting benzodiazepine used for a number of conditions such as anxiety-related disorders, including anxiety caused by depression and panic attacks. (fmtmedicalstore.com)
Extended-release tablet2
- Alprazolam comes as a tablet, an extended-release tablet, an orally disintegrating tablet (tablet that dissolves quickly in the mouth), and a concentrated solution (liquid) to take by mouth. (medlineplus.gov)
- There were significant differences in absorption rate for the alprazolam extended-release tablet, depending on the time of day administered, with the C max increased by 30% and the T max decreased by an hour following dosing at night, compared to morning dosing. (nih.gov)
Xanax5
- The ingredients in Xanax XR and alprazolam XR are identical (or neatly identical depending on the amounts used). (yarpg.de)
- How Xanax Alprazolam Treats Anxiety? (articleswork.com)
- Home / Health and Medical / How Xanax Alprazolam Treats Anxiety? (articleswork.com)
- XANAX XR 3MG is the brand-name drug of Alprazolam that functions as a short-acting tranquilizer of the Triazolobenzodiazepine class. (trinexpharmacy.com)
- Many people take alprazolam (brand name Xanax ) to treat symptoms of anxiety or panic disorder. (arkbh.com)
Effects of alprazolam1
- The subjective and behavioral effects of sertraline were studied and compared with the effects of alprazolam and dextroamphetamine in a within-subject, randomized, double-blind study in 20 volunteers aged 18 to 46 years. (biopsychiatry.com)
Anxiety disorders2
- Alprazolam is a well-known and highly characterized benzodiazepine typically prescribed for the treatment of anxiety disorders. (drugdiscoverynews.com)
- Alprazolam is a triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of panic disorders, with or without agoraphobia, and in generalized anxiety disorders. (medswow.com)
Medications2
- Alprazolam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. (medlineplus.gov)
- If you take alprazolam with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. (medlineplus.gov)
Doses4
- Alprazolam may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. (medlineplus.gov)
- At 1 hour postdrug administration, dextroamphetamine and alprazolam produced positive effects on several measures of elation, euphoria, and drug liking greater than placebo and both doses of sertraline. (biopsychiatry.com)
- Results from this study indicate that sertraline, at the doses tested, does not possess the behavioral effects profile considered to be indicative of abuse potential when compared with alprazolam and dextroamphetamine. (biopsychiatry.com)
- The study referenced in the Epilepsia paper demonstrated that three doses of Staccato alprazolam (0.5 mg, 1.0 mg, and 2.0 mg) rapidly suppressed epileptiform activity in photosensitive participants with epilepsy. (drugdiscoverynews.com)
POWDER1
- Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH. (nih.gov)
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Tablets4
- Following oral administration of alprazolam (immediate-release) tablets, alprazolam is readily absorbed. (nih.gov)
- The apparent volume of distribution of alprazolam is similar for alprazolam extended-release and alprazolam tablets. (nih.gov)
- The plasma concentrations of 4-hydroxyalprazolam and α-hydroxyalprazolam relative to unchanged alprazolam concentration after both alprazolam extended-release and alprazolam tablets were always less than 10% and 4%, respectively. (nih.gov)
- Alprazolam orally disintegrating tablets, USP are indicated for the treatment of generalized anxiety disorder. (yarpg.de)
Elimination1
- Using a specific assay methodology, the mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3-26.9 hours) in healthy adults. (nih.gov)
Humans1
- A benzophenone derived from alprazolam is also found in humans. (nih.gov)
Drug4
- Staccato alprazolam is a single-use, investigational epileptic seizure rescue therapy that combines Staccato delivery technology with alprazolam, both of which have been approved separately for unrelated indications by the U.S. Food and Drug Administration. (drugdiscoverynews.com)
- This proof-of-concept study demonstrated that Staccato alprazolam delivered the drug deep into to the lung and rapidly suppressed seizure or epileptiform activity in five photosensitive patients with epilepsy. (drugdiscoverynews.com)
- As a highly potent drug in the benzodiazepine family, Alprazolam is a medicine that should only be taken under the care of your physician. (alprazolam.org)
- Also, remember that improper use of this drug can be fatal, so be sure to only make changes to your Alprazolam dosage under the care of your medical doctor. (alprazolam.org)
Diazepam1
- Diazepam and Alprazolam could also be used, however these are controlled substances therefore are less convenient. (maroon5.com)
Generally2
- Staccato alprazolam was generally well tolerated, with a safety profile similar to what has been reported for oral alprazolam or Staccato alprazolam for other indications. (drugdiscoverynews.com)
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Panic disorder2
- Alprazolam is used for the management of anxiety disorder or the short-term relief of symptoms of anxiety caused by depression and anxiety, for the treatment of panic disorder, with or without agoraphobia. (medswow.com)
- Alprazolam, a benzodiazepine, is used to treat panic disorder and anxiety disorder. (medswow.com)
Treatment4
- Drinking alcohol or using street drugs during your treatment with alprazolam also increases the risk that you will experience these serious, life-threatening side effects. (medlineplus.gov)
- The encouraging data from this Phase 2a study served as the foundation for advancing Staccato alprazolam in the clinic as a potential rescue medication for the acute treatment of seizures. (drugdiscoverynews.com)
- Data from this proof‐of‐concept study showed that treatment with Staccato alprazolam was effective in reducing the SPR at the earliest measurable time point (2 minutes). (drugdiscoverynews.com)
- Many people who need Alprazolam don't seek treatment because they don't think their anxiety symptoms are treatable. (alprazolam.org)
Occur1
- Keep in mind that these side effects may not occur in everyone who uses Alprazolam. (alprazolam.org)
Adults1
- Alprazolam can be harmful among adults at her age. (medscape.com)
Symptoms3
- Stopping alprazolam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. (medlineplus.gov)
- If you regularly experience any of these symptoms as a result of anxiety, then Alprazolam may be right for you. (alprazolam.org)
- Consult your health care provider, they should be able to determine if the symptoms are indeed related to anxiety and can prescribe Alprazolam accordingly. (alprazolam.org)
Pharmacy1
- Use this FREE Alprazolam pharmacy coupon to get the lowest price on your pet's Alprazolam prescription. (petdrugcard.com)
Treat1
- Alprazolam also works to treat panic disorders. (alprazolam.org)
Medical1
- All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Alprazolam. (medswow.com)
Common2
- Common alprazolam side effects may include: drowsiness, feeling tired, slurred speech, lack of balance or coordination, memory problems or feeling anxious early in the morning. (medswow.com)
- Like any other prescription medication, Alprazolam has some common side effects. (alprazolam.org)
Similar1
- Their half-lives appear to be similar to that of alprazolam. (nih.gov)
Mental1
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Quantity1
- This proof‐of‐concept study did show that the Staccato system delivered a sufficient quantity of alprazolam to suppress epileptiform activity at an early time point. (drugdiscoverynews.com)
Experience1
- If you experience any of these side effect while taking Alprazolam, then consult your physician if you find them to be too bothersome. (alprazolam.org)
