Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238)Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.Panic: A state of extreme acute, intense anxiety and unreasoning fear accompanied by disorganization of personality function.Agoraphobia: Obsessive, persistent, intense fear of open places.Anxiety: Feeling or emotion of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.Anti-Anxiety Agents: Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Anxiety Disorders: Persistent and disabling ANXIETY.Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Propranolol: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Fructose: A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.Migraine with Aura: A subtype of migraine disorder, characterized by recurrent attacks of reversible neurological symptoms (aura) that precede or accompany the headache. Aura may include a combination of sensory disturbances, such as blurred VISION; HALLUCINATIONS; VERTIGO; NUMBNESS; and difficulty in concentrating and speaking. Aura is usually followed by features of the COMMON MIGRAINE, such as PHOTOPHOBIA; PHONOPHOBIA; and NAUSEA. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Hallucinations: Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.Ketoconazole: Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.Tripelennamine: A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.Valerian: A plant genus of the family VALERIANACEAE, order Dipsacales, subclass Asteridae, class Magnoliopsida. It is best known for the sedative use and valepotriate content of the roots. It is sometimes called Garden Heliotrope but is unrelated to true Heliotrope (HELIOTROPIUM).Orgasm: The climax of sexual excitement in either humans or animals.Irritable Mood: Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.Dissent and Disputes: Differences of opinion or disagreements that may arise, for example, between health professionals and patients or their families, or against a political regime.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Benzodiazepines: A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.Slovenia: Created 7 April 1992 as a result of the division of Yugoslavia.Serbia: A republic located south of HUNGARY, west of ROMANIA and BULGARIA, and part of the former YUGOSLAVIA. The capital is Belgrade.Drugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Yugoslavia: Created as the Kingdom of Serbs, Croats, and Slovenes in 1918. Yugoslavia became the official name in 1929. BOSNIA-HERZEGOVINA; CROATIA; and SLOVENIA formed independent countries 7 April 1992. Macedonia became independent 8 February 1994 as the Former Yugoslav Republic of Macedonia (MACEDONIA REPUBLIC).EuropeCapsules: Hard or soft soluble containers used for the oral administration of medicine.

A double-peak phenomenon in the pharmacokinetics of alprazolam after oral administration. (1/117)

The pharmacokinetics of alprazolam (ALP) after i.v. and p.o. administration in rats were characterized. ALP decayed biexponentially after the i.v. dose (1.25 mg/kg), but the concentration-time profiles after the p.o. doses (7 and 12.5 mg/kg) exhibited a double-peak phenomenon. The presence of two peaks was confirmed by statistical analysis of the serum concentration data of ALP, as well as by observed double peaks in the serum concentration-time profiles of the two active metabolites (alpha-hydroxyalprazolam and 4-hydroxyalprazolam). An absorption model incorporating a delay site is proposed to describe the data, and the absolute oral bioavailability is estimated to be about 30%. The two peaks were approximately 80 to 115 min apart, and there was a delay in the absorption of close to 80% of oral ALP, regardless of dose. We hypothesize that the mechanism underlying the double-peak phenomenon is due to reduction in gastric motility caused by the muscle relaxant effect of ALP. This hypothesis is supported by the observed longer delay in the appearance of the second peak at the higher p.o. dose. Enterohepatic recycling is precluded from being the underlying mechanism, because of the presence of double peaks after the p.o. doses but not after the i.v. dose. This is the first reported case of double peaks for oral ALP, and this phenomenon has not been reported for other benzodiazepines. The double-peak phenomenon caused by the hypothesized mechanism may have important therapeutic and drug interaction implications, especially because benzodiazepines are commonly coadministered with other drugs.  (+info)

Quantitation of alprazolam and alpha-hydroxyalprazolam in human plasma using liquid chromatography electrospray ionization MS-MS. (2/117)

A sensitive and specific electrospray ionization high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method has been developed for the quantitative determination of alprazolam (AL) and alpha-hydroxyalprazolam (OH-AL) in plasma. After the addition of deuterium labeled internal standards of AL and OH-AL, plasma samples were buffered to alkaline pH and extracted with toluene/methylene chloride (7:3). Dried extract residues were reconstituted in HPLC mobile phase and injected onto a reversed-phase C18 HPLC column. The analytes were eluted isocratically at a flow rate of 250 microL/min using a solvent composed of methanol and water (60:40) containing 0.1% formic acid. The analyses were performed using selected reaction monitoring. The assay was sensitive to 0.05 ng/mL for both the parent drug and metabolite and linear to 50 ng/mL. The intra-assay percent coefficients of variation (%CV) for AL at 2, 5, and 20 ng/mL were all < or = 5.6. At these concentrations, and all OH-AL intra-assay %CVs were < or = 8.4. The interassay variabilities for AL were 11.8%CV, 8.7%CV, and 8.7%CV at 2.0, 5.0, and 20.0 ng/mL, respectively. The OH-AL interassay variabilities were 9.6%CV, 9.2%CV, and 7.8%CV at the same concentrations, respectively. The assay accuracy was less than or equal to +/- 6.6% for both analytes at the three concentrations. The method was used to quantitate AL and OH-AL in plasma samples collected from 10 subjects who were administered a 1-mg oral dose of AL. The mean AL concentration peaked at 11.5 ng/mL 1 h after the dose and AL was detectable for 48 h. The mean OH-AL concentration peaked at 0.18 ng/mL 4 h after the dose and was undetectable by 36 h. Hydrolysis of the plasma samples had little effect on the detected AL concentrations but increased OH-AL concentrations substantially. Plasma/blood ratios for AL and OH-AL exceeded 1 in the study samples.  (+info)

Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. (3/117)

In view of the substantial preclinical evidence that supports a seminal role of central corticotropin-releasing factor (CRF) neuronal systems in the physiology and pathophysiology of stress and anxiety, it is reasonable to suggest that the anxiolytic properties of benzodiazepines are mediated, at least in part, via regulation of CRFergic function. To begin to test this complex hypothesis, we examined the effects of acute and chronic administration of the triazolobenzodiazepine agonist alprazolam on CRF peptide concentrations, receptor-binding density, and mRNA expression in the CNS. Additionally, we measured mRNA expression for urocortin, a recently discovered neuropeptide that is generally considered to be a second endogenous ligand for CRF receptors. Both acute and chronic alprazolam administration was found to decrease CRF concentrations within the locus coeruleus. Furthermore, chronic alprazolam decreased basal activity of the hypothalamic-pituitary-adrenal axis, CRF mRNA expression in the central nucleus of the amygdala, and CRF(1) mRNA expression and receptor binding in the basolateral amygdala. In marked contrast, urocortin mRNA expression in the Edinger-Westphal nucleus and CRF(2A) receptor binding in the lateral septum and ventromedial hypothalamus were increased. Similar findings of an inverse relationship between the CRF(1) and CRF(2A) receptor systems have been reported in an anxiety model based on adverse early-life experience, suggesting the intriguing possibility that CRF neuronal systems may be comprised of two separate, but interrelated, subdivisions that can be coordinately and inversely regulated by stress, anxiety, or anxiolytic drugs.  (+info)

Effects of age on in vitro midazolam biotransformation in male CD-1 mouse liver microsomes. (4/117)

To study age-related changes in drug metabolism, we examined the in vitro biotransformation of midazolam (MDZ), a human cytochrome P-450 (CYP) 3A substrate, using liver microsomes from three age groups of male CD-1 mice ranging from 6 weeks to 2 years old. MDZ was metabolized to two major products, alpha-OH- and 4-OH-MDZ, which were quantified by HPLC. For both metabolites, V(max) values were reduced in old livers (P <.05), while K(m) values did not change with age. The net intrinsic clearance (the sum of V(max)/K(m) for both pathways) also was reduced in the old animals (P <.05). The capacity of ketoconazole, a CYP3A inhibitor in humans, to inhibit the biotransformation of MDZ and of alprazolam, another human CYP3A substrate, did not differ significantly with age. At 100 microM alprazolam, 0.5 microM ketoconazole inhibited metabolite formation by >80%. At 30 microM MDZ, 2.5 microM ketoconazole impaired 4-OH-MDZ formation by 88%, whereas it reduced alpha-OH-MDZ formation by only 46%. Immunoinhibition studies with polyclonal anti-rat CYP3A1/2 and CYP2C11 antibodies confirmed that 4-OH-MDZ formation was largely CYP3A-dependent, while alpha-OH-MDZ formation was mediated by CYP3A and -2C isoforms. Western blot analysis revealed decreased microsomal content of CYP3A in old livers. Net intrinsic clearance of MDZ was correlated with total CYP3A content (P <.001). These results demonstrate a reduction in MDZ biotransformation in old male mice, which may be attributable, in part, to decreased CYP3A content in old livers. Changes in expression and activity of CYP2C isoforms also may contribute to age-related changes in MDZ biotransformation, but this requires more investigation.  (+info)

Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance. (5/117)

The partial allosteric modulators (PAMs) of gamma-aminobutyric acid-gated Cl(-) current intensities at gamma-aminobutyric acid type A receptors have high affinity but low intrinsic efficacy on benzodiazepine recognition sites. Unlike the full allosteric modulators (FAM), like alprazolam, triazolam, and diazepam, PAMs are virtually devoid of unwanted side effects, including tolerance. Imidazenil (IMD) is a PAM that elicits potent anxiolytic and anticonvulsant actions in rodents and nonhuman primates and retains its anticonvulsant and anxiolytic effects, even in rodents that are tolerant to FAMs. IMD antagonizes the side effects of FAMs in rodents and nonhuman primates. Using patas monkeys and a multiple schedule with repeated acquisition and performance of chain responses, we report that IMD administration for 17 days antagonized without showing tolerance ALP-induced disruption of acquisition.  (+info)

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat. (6/117)

The biochemical and behavioral effects of a nonpeptidic, selective, and brain-penetrant agonist at the ORL1 receptor are reported herein. This low molecular weight compound [(1S,3aS)-8- (2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza- spiro[4. 5]decan-4-one] has high affinity for recombinant human ORL1 receptors and has 100-fold selectivity for ORL1 over other members of the opioid receptor family. It is a full agonist at these receptors and elicits dose-dependent anxiolytic-like effects in a set of validated models of distinct types of anxiety states in the rat (i.e., elevated plus-maze, fear-potentiated startle, and operant conflict). When given systemically, the compound has an efficacy and potency comparable to those of a benzodiazepine anxiolytic such as alprazolam or diazepam. However, this compound is differentiated from a classical benzodiazepine anxiolytic by a lack of efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). No significant change in intracranial self-stimulation performance and pain reactivity was observed in this dose range. Higher doses of this compound (>/=10 mg/kg) induced disruption in rat behavior. These data confirm the notable anxiolytic-like effects observed at low doses with the orphanin FQ/nociceptin neuropeptide given locally into the brain and support a role for orphanin FQ/nociceptin in adaptive behavioral fear responses to stress.  (+info)

Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. (7/117)

Assuming complete hepatic substrate metabolism and system linearity, quantitative effects of in vivo competitive inhibition are investigated. Following oral administration of a substrate in the presence of a competitive inhibitor, determination of the inhibition constant (Ki) is possible when plasma concentration-time profiles of both substrate and inhibitor are available. When triazolam is the P450 3A4 substrate and ketoconazole the competitive inhibitor, Ki approximately 1.2 microg/mL in humans. The effects of competitive inhibition can be divided into two components: first-pass hepatic metabolism and systemic metabolism. For drugs with high hepatic extraction ratios, the impact of competitive inhibition on hepatic first-pass metabolism can be particularly dramatic. For example, human terfenadine hepatic extraction goes from 95% in the absence of a competitive inhibitor to 35% in the presence of one (ketoconazole, 200 mg po Q 12 h dosed to steady-state). First-pass extraction therefore goes from 5% in the absence of the inhibitor to 65% in its presence. The combined effect on first-pass and systemic metabolism produces an approximate 37 fold increase in terfenadine area under the plasma concentration-time curve. Assuming intact drug is active and/or toxic, development of metabolized drugs with extensive first-pass metabolism should be avoided if possible, since inhibition of metabolism may lead to profound increases in exposure.  (+info)

Characterization of the anxiolytic properties of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), a selective modulator of gamma-aminobutyric acid(A) receptors. (8/117)

The purpose of this study was to evaluate the effects of a novel neuroactive steroid, Co 2-6749 (GMA-839; WAY-141839; 3alpha, 21-dihydroxy-3beta-trifluoromethyl-19-nor-5beta-pregnan-20-one), on gamma-aminobutyric acid(A) receptors in vitro and to define its anxiolytic-like effects and side effect profile in vivo. Co 2-6749 fully inhibited [(35)S]t-butylbicyclophosphorothionate binding in rat brain cortical membranes with an IC(50) value of 230 nM and in human gamma-aminobutyric acid(A) receptor subunit combinations of alpha1beta2gamma2L, alpha2beta2gamma2L, alpha3beta2gamma2L, alpha4beta3gamma2L, alpha5beta2gamma2L, and alpha6beta3gamma2L receptors (IC(50) values of 200, 200, 96, 2300, 210, and 2000 nM). Rats were trained in a Geller-Seifter operant conflict paradigm. Co 2-6749 caused a dose-related increase in punished responding with a minimum effective dose of 1.6 mg/kg, p.o., a wide therapeutic index relative to a decrease in unpunished responding and relative to ataxia, and no tolerance. Additionally, ethanol caused less than a 2-fold shift to the left in the dose-response function of Co 2-6749 in the rotorod procedure in rats. In a pigeon conflict paradigm, punished responding was maximally increased to 784% of vehicle control by 30 mg/kg, p.o., with a 2-h duration and no effect on unpunished responding at this dose. Similarly, punished responding in squirrel monkeys was maximally increased to 1774% of control by 10 mg/kg, p.o., with no effect on unpunished responding at this dose. With robust anxiolytic-like activity across species, a large separation between anxiolytic-like effects and sedation/ataxia, a minimal interaction with ethanol, a lack of tolerance, and apparent oral bioavailability, Co 2-6749 makes an ideal candidate for development as a novel anxiolytic drug.  (+info)

*Alprazolam

In the UK, alprazolam is recommended for the short-term treatment (2-4 weeks) of severe acute anxiety. Alprazolam may be used ... Alprazolam is taken orally, and is absorbed well - 80% of alprazolam binds to proteins in the serum (the majority binding to ... Alprazolam oral solutions are available as 0.5 mg/5 mL and as 1 mg/1 mL oral solutions. Inactive ingredients in alprazolam ... In Ireland, alprazolam is a Schedule 4 medicine. In Sweden, alprazolam is a prescription drug in List IV (Schedule 4) under the ...

*DMOZ - Health: Pharmacy: Drugs and Medications: A: Alprazolam

Alprazolam, sold under the brand name Xanax, is indicated for the management of anxiety disorder or the short-term relief of ... Alprazolam, sold under the brand name Xanax, is indicated for the management of anxiety disorder or the short-term relief of ...

*Benzodiazepine use disorder

"DB00404 (Alprazolam)". Canada: DrugBank. 26 August 2008. Bergman, U.; Dahl-Puustinen, M. L. (1989). "Use of prescription ... Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse ... Evans, S. M.; Levin, F. R.; Fischman, M. W. (Jun 2000). "Increased sensitivity to alprazolam in females with a paternal history ... Wang, E.C.; Chew, F. S. (2006). "MR Findings of Alprazolam Injection into the Femoral Artery with Microembolization and ...

*Effects of long-term benzodiazepine use

A study of alprazolam found that 8 weeks administration of alprazolam resulted in deficits that were detectable after several ... A study found that of 42 patients treated with alprazolam, up to a third of long-term users of the benzodiazepine drug ... Kiliç C, Curran HV, Noshirvani H, Marks IM, Başoğlu M (January 1999). "Long-term effects of alprazolam on memory: a 3.5 year ... Juergens, Sm; Morse, Rm (May 1988). "Alprazolam dependence in seven patients". The American Journal of Psychiatry. 145 (5): 625 ...

*Adrenergic storm

... alprazolam and propranolol; alprazolam weakly agonizes dopamine receptors and causes catecholamine release while propranolol ...

*Misuse of Drugs Act 1975

... alprazolam, lorazepam, nitrazepam, etc.) ^Note 1 : Pentobarbital, secobarbital and amobarbital are subject to more legal ...

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A clinical trial of patients taking the benzodiazepine alprazolam for as short as eight weeks triggered protracted symptoms of ... Haque, W; Watson, DJ; Bryant, SG (1990). "Death following suspected alprazolam withdrawal seizures: A case report". Texas ... Benzodiazepines with a half-life of less than 24 hours include alprazolam, bromazepam, brotizolam, flunitrazepam, loprazolam, ... Pecknold, J.C. (1993). "Discontinuation reactions to alprazolam in panic disorder". Journal of Psychiatric Research. 27: 155- ...

*Benzodiazepine overdose

By National Institute on Drug Abuse (NIDA). Wolf BC, Lavezzi WA, Sullivan LM, Middleberg RA, Flannagan LM (2005). "Alprazolam- ... Isbister GK, O'Regan L, Sibbritt D, Whyte IM (July 2004). "Alprazolam is relatively more toxic than other benzodiazepines in ... Rogers, Wo; Hall, Ma; Brissie, Rm; Robinson, Ca (Jan 1997). "Detection of alprazolam in three cases of methadone/benzodiazepine ... An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most ...

*Separation anxiety in dogs

Benzodiazepines, such as alprazolam, are anxiolytic medications. Benzodiazepines have also shown to be beneficial in the ... alprazolam, and behavior modification for treatment of storm phobia in dogs". Journal of the American Veterinary Medical ... that 30 out of the 32 canines involved in the study had reductions in anxiety behavior after being treated with alprazolam. ...

*Adinazolam

Benzodiazepine Alprazolam FR Patent 2248050 Karthik Venkatakrishnan; Lisa L. Von Moltke; Su Xiang Duan; Joseph C. Fleishaker; ... Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed. Adinazolam ...

*Mood disorder

Benzodiazepines, such as alprazolam, clonazepam, lorazepam and diazepam, can cause both depression and mania. Benzodiazepines ... "Discontinuation of Alprazolam Treatment in Panic Patients". Am J Psychiatry. benzo.org.uk. 144 (3): 303-8. doi:10.1176/ajp. ... "Emergence of depressive symptoms in patients receiving alprazolam for panic disorder". Am J Psychiatry. 144 (5): 664-5. doi: ...

*Pyrazolam

... has structural similarities to alprazolam and bromazepam. Unlike other benzodiazepines, pyrazolam does not appear to ...

*Generalized anxiety disorder

Popular benzodiazepines for GAD include alprazolam, lorazepam, and clonazepam. The World Council of Anxiety does not recommend ... alprazolam and venlafaxine but pregabalin has demonstrated superiority by producing more consistent therapeutic effects for ...

*Caffeine-induced anxiety disorder

For individuals prescribed anti-anxiety medications such as Alprazolam (Xanax), caffeine can introduce further problems by ... "Caffeine augments Alprazolam induced cytotoxicity in human cell lines". Toxicology in Vitro. 23 (6): 1100-1109. doi:10.1016/j. ...

*William Shell

Alprazolam 0.5 mg and GABAdone); Gaboxetine Convenience Pack (Fluoxetine 10 mg and GABAdone); Trazamine Convenience Pack ( ...

*Pfizer

Xanax and Xanax XR (alprazolam) for anxiety and panic disorders. In addition to marketing branded pharmaceuticals, Pfizer is ...

*Abecarnil

Jung ME, Wallis CJ, Gatch MB, Lal H (Jun 2000). "Abecarnil and alprazolam reverse anxiety-like behaviors induced by ethanol ... Pinna G, Galici R, Schneider HH, Stephens DN, Turski L (Mar 1997). "Alprazolam dependence prevented by substituting with the ...

*Sedative

"Emergence of depressive symptoms in patients receiving alprazolam for panic disorder". Am J Psychiatry. 144 (5): 664-5. doi: ... Diazepam Estazolam Flunitrazepam Lorazepam Midazolam Nitrazepam Oxazepam Triazolam Temazepam Chlordiazepoxide Alprazolam ...

*Benzodiazepine

Matar MA, Zohar J, Kaplan Z, Cohen H (April 2009). "Alprazolam treatment immediately after stress exposure interferes with the ... Examples are alprazolam, estazolam, flunitrazepam, clonazepam, lormetazepam, lorazepam, nitrazepam, and temazepam. Long-acting ... Wilhelm FH, Roth WT (September 1997). "Acute and delayed effects of alprazolam on flight phobics during exposure". Behaviour ... The high potency benzodiazepines alprazolam and triazolam and long-acting benzodiazepines are not recommended in the elderly ...

*Panic disorder

June 1993). "Alprazolam and exposure alone and combined in panic disorder with agoraphobia. A controlled study in London and ... Moylan S, Giorlando F, Nordfjærn T, Berk M (March 2012). "The role of alprazolam for the treatment of panic disorder in ...

*Euphoria

Benzodiazepines more likely to cause euphoria are flunitrazepam, alprazolam and clonazepam. Benzodiazepines also tend to ...

*Murder of Sandra Cantu

Her toxicology results showed the presence of Alprazolam, also known as Xanax. Upon remains having been found, police became ...

*Drug-related crime

Alprazolam has been abused for the purpose of carrying out acts of incest and for the corruption of adolescent girls. However, ... Kintz P; Villain M; Chèze M; Pépin G. (October 29, 2005). "Identification of alprazolam in hair in two cases of drug- ...

*Paradoxical reaction

1993). "Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines". The Journal of Clinical ...

*Bretazenil

Apr 1994). "Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans". Clin Pharmacol Ther. ... also has been found to have less abuse potential than benzodiazepine full agonists such as diazepam and alprazolam,[3] long- ...
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AIMS: To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines. METHODS: A database of consecutive poisoning admissions to a regional toxicology service was searched to identify consecutive benzodiazepine deliberate self poisonings, which were coded as alprazolam, diazepam or other benzodiazepine. Major outcomes used were length of stay (LOS), intensive care (ICU) admission, coma (GCS > 9), flumazenil administration and requirement for mechanical ventilation. Prescription data were obtained for benzodiazepines for the study period. RESULTS: There were 2063 single benzodiazepine overdose admissions: 131 alprazolam overdoses, 823 diazepam overdoses and 1109 other benzodiazepine overdoses. The median LOS for alprazolam overdoses was 19 h which was 1.27 (95% CI 1.04, 1.54) times longer compared with other benzodiazepines by multiple linear regression. For patients with alprazolam overdoses, 22% were admitted to ICU which was 2.06 (95% CI 1.27, ...
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A powerful anti-anxiety drug has been involved in a rising number of heroin-related deaths (HRDs) in Victoria in recent years, according to new research.. In a paper published in the Medical Journal of Australia today, researchers from Monash University called for the prescription and scheduling of the benzodiazepine alprazolam to be examined, after their study uncovered a dramatic increase in the supply of this drug, and detection in a rising rate of HRDs.. The findings come weeks before the Therapeutic Goods Association is due to meet to discuss whether more restrictions should be placed on the availability of benzodiazepines.. Alprazolam is a psychoactive drug approved for the short-term treatment of anxiety and panic disorder in Australia. Alprazolam is not recommended as a firstline treatment for these conditions due to concern about dependence, the potential for its misuse and because non-pharmaceutical interventions, such as cognitive behavioural therapy, have been found to be more ...
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Because the management of panic disorder often requires the use of average daily doses of alprazolam above 4 mg, the risk of dependence among panic disorder patients may be higher than that among those treated for less severe anxiety. Experience in randomized placebo-controlled discontinuation studies of patients with panic disorder showed a high rate of rebound and withdrawal symptoms in patients treated with alprazolam compared to placebo-treated patients.. Relapse or return of illness was defined as a return of symptoms characteristic of panic disorder (primarily panic attacks) to levels approximately equal to those seen at baseline before active treatment was initiated. Rebound refers to a return of symptoms of panic disorder to a level substantially greater in frequency, or more severe in intensity than seen at baseline. Withdrawal symptoms were identified as those which were generally not characteristic of panic disorder and which occurred for the first time more frequently during ...
Pharmacokinetics in Humans1. POWELL-JACKSON, A. JAMIESON, B. Opiate, J. MOXHAM, and R. Ya de paso me gustaría saber si alguien ha tomado ambos principios activos (Alprazolam y Lorazepam) y puede dejar una opinión de sus diferencias. Según wikipedia Lorazepam es destacado en todos los efectos típicos de las benzodiazepinas, ansiolítico, miorrelajante, hipnótico y sedante. veces menos dosis). Triazolam, alprazolam, clonazepam y lorazepam están entre los ansiolíticos que necesitan menos cantidad de principio activo (dosis más pequeñas). De todas formas, es el psiquiatra el que tiene que decidirse por uno u otro, ya que hay diferencias entre ellos. +1 de acuerdos Primero en responder.. ...
Onset: Alprazolam IR : 8-25 minutes Alprazolam XR : 25-75 minutes Diazepam : Rapid Clonazapam : 1 hour Lorazepam : 1-2 hours Peak Benefit: Diazepam: 1.6 hours Alprazolam IR : 90 minutes Alprazolam XR : 25-75 minutes Diazepam : 2-4 hours Clonazapam: 1-4 hours Half/Life and Duration Triazolam: 2.5 Hours Lorazepam: 10-20 hours - 6-12 hour duration Alprazolam IR : 11 hour half life - 5 hour duration Alprazolam XR :11-16 hour hour half life, 11 hour duration Diazepam : 20-100 hour half life - 6-8 hour duration Clonazepam: 18-50 hour half life - 12+ hours Dosages Depend on tolerance. Potentiators: -Grapefruit juice Avoid: -Excessive drinking (you will die) ...
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Alprazolam. Molecular model of the sedative drug alprazolam (C17.H13.Cl.N4). Sold under the brand name Xanax, it is from a class of drugs known as benzodiazepines. Atoms are represented as spheres and are colour-coded: carbon (grey), hydrogen (white), chlorine (green) and nitrogen (blue). Illustration. - Stock Image F017/0169
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An Open Label, Crossover, Randomized Study of Two Periods, Two Treatments, Two Sequences, and a Single Dose of Two Oral Drug Products of Alprazolam 2mg (Tafil ® 2 mg, Product of Pharmacia & Upjohn SA de CV vs Xanax ® 2 mg, Product of Pfizer Pharmaceuticals LLC) in Healthy Volunteers in Fasting ...
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Cohn JB, The Journal of clinical psychiatry, Buspirone was compared to alprazolam and lorazepam in the treatment of generalized anxiety disorder in a 4-week, double-blind study of 60 patients. Al
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Reidbord on solubility of alprazolam: Tramadol is used for pain relief and has less addiction risks than narcotics. Pain can cause anxiety and vise versa. I believe that ativan, (lorazepam) a benzodiazepine that decreases anxiety, can increase effects of tramadol. Reisk of abuse increase though!
Alprazolam, sold under the brand name Xanax, is indicated for the management of anxiety disorder or the short-term relief of symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an antiolytic medication. Xanax is also indicated for the treatment of panic disorder, with or without agoraphobia.
About the Drug. Xanax (Alprazolam) is used to treat anxiety and panic disorders. It has also been used to treat depression, agoraphobia, and premenstrual syndrome. Xanax works by decreasing abnormal brain excitement.. Use of Information. GetMentalHealthy.com is providing this information solely & freely for educational purposes. Always seek professional consult with your healthcare provider if you have any questions or concerns. This information can be used as an educational guide, however not every drug interaction or side effect may be listed.. Proper Usage. Xanax comes in both tablet and liquid form and is taken 2-4 times per day. Your doctor will start you on a low dose and then slowly increase the dosage. When taking the liquid form only use the dropper that comes with the medication. Use the dropper to draw up the dose then squeeze into juice, soda, pudding or applesauce and gently stir. The medication will blend with the food or drink. Drink or eat immediately and do not save for later ...
... is a prescription drug used to treat anxiety and panic disorder. This eMedTV article provides more information about the uses and effects of this drug, and also covers dosing guidelines and potential side effects.
... is a prescription drug used to treat anxiety and panic disorder. This eMedTV article provides more information about the uses and effects of this drug, and also covers dosing guidelines and potential side effects.
Alprazolam is a short acting benzodiazepine, it does not last long in the system. So when used regularly with multiple doses to treat anxiety, it is associated with inter-dose withdrawal, tolerance and a resulting increase level of baseline anxiety. So in anxiety clinics, we use it only in cases of " flight, dentist or other infrequent anxieties, not on daily basis.
Abstract: "n 800x600 Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman","serif";} Background: Alprazolam belongs to benzodiazepine family and is increasingly used these days by pregnant women. It should be noticed that alprazolam exposure during pregnancy may have teratogenic effects on the fetus. Till now, limited studies have been conducted on the teratogenic effect of alprazolam. In this study, teratogenicity of alprazolam intake during pregnancy and its effects on fetus development was investigated. "n"nMethods: About 20 virgin rats of known age and weight were selected. After being pregnant, they were divided ...
Xanax (Alprazolam) is regarded as the single most popular benzodiazepine in the world. It is a highly effective drug when utilized for the medical treatm
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The study is a phase I, open, randomised, crossover, single dose pharmacokinetic study performed in a single centre. The study consists of 2 treatment periods, during which the study subjects will receive the test product and the reference product in a randomised order. During both treatment periods, the study subjects will receive 1 mg of alprazolam as a single oral dose. The study treatments will be administered after an overnight fast (at least 10 h). Blood samples will be drawn during both treatment periods. The planned duration of the study per subject will be 4-5 weeks including a screening visit, 2 treatment periods with a wash-out between the study treatment administrations and a post-treatment period ...
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To the physicians representative that called in alprazolam 20 mg......this is not the same as omeprazole 20 mg. Thankfully i took the the time to look on the patients profile to verify the patients medications so i knew what i was doing before calling back to verify the script. thank god at least one of us is not a complete moron. And when i call back and speak with you, please do not dismiss it as some simple mistake. I repeated the correct pronounciation three times while one the phone with you, stressing the difference between these medications, yet I still dont think you grasped the concept that these are TWO different medications with TWO COMPLETELY DIFFERENT MOAs. Not even remotely the same strengths. Yet you are allowed to call in these medications with virtually no training. Thankfully the KYBOP requires that a pharmacist or intern take new prescriptions. I just saved you and your doctors ass. And you arent even thankful. Maybe next time, slow the fuck down when you leave a message and ...
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Serious allergic reactions. Additional questions regarding Xanax. How long does Xanax remain in the system after you take it?. One of the things about Xanax is that the length of time it stays in your system is going to vary. Xanax isnt a medication you can take and then once you stop using it it will just leave your system fast. Xanax takes some time to recover from and get completely out of your system. When you go to the bathroom to urinate, the amount of the drug you tend to releaser is only about 1%. So if the goal was to get the drug out of your body by a certain time, then you would need to be taking minimum doses in order to have the best chance for it to be out of your body within a few days.. Are Alprazolam and Xanax the exact same thing?. There are a lot of people who are worried about whether or not theres a difference between the getting this in generic form and getting it in name brand form. The thinking is that one isnt going to work as well as the other. Well generic Xanax is ...
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Anyone know the maximum solubility of these two compounds in either 100% ethanol or in a polyethylene glycol mix? Ive heard 2 mg/mL in grain alcohol for alprazolam, but I was wondering if anyone has any more info on the solubility for either of these compounds. Thanks.
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The present invention relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or triazolam, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
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This article lists veterinary pharmaceutical drugs alphabetically by name. Many veterinary drugs have more than one name and, therefore, the same drug may be listed more than once. Brand names and active ingredient (generic) names are differentiated by the use of capital initials for brand names, and lower case letter for active ingredient names. Abbreviations are used in the list as follows: INN = International Nonproprietary Name BAN = British Approved Name USAN = United States Adopted Name Contents: Top 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z acepromazine - sedative, tranquilizer, and antiemetic alprazolam - benzodiazepine used as an anxiolytic and tranquilizer altrenogest - used to synchronize estrus amantadine - as an analgesic for chronic pain aminophylline - bronchodilator amitraz - antiparasitic used to control ticks, mites, lice and other animal pests. Cannot be used on horses or cats. amitriptyline - tricyclic antidepressant used to treat separation anxiety, excessive ...
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ALPRAZOLAM- alprazolam tablet To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application ... The average dose of alprazolam was 5 to 6 mg/day in two of the studies, and the doses of alprazolam were fixed at 2 and 6 mg/ ... Alprazolam Interaction With Drugs That Inhibit Metabolism Via Cytochrome P450 3A. The initial step in alprazolam metabolism is ... Drugs that inhibit alprazolam metabolism via cytochrome P450 3A. The initial step in alprazolam metabolism is hydroxylation ...
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Alprazolam: uses & side-effects | PatientsLikeMeAlprazolam: uses & side-effects | PatientsLikeMe

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Alprazolam) is prescribed for treating generalized anxiety disorder (GAD), anxiety associated with depression, and panic ... A: Xanax XR (alprazolam XR) is an extended-release formulation of alprazolam. It is commonly dosed once a day and indicated for ... A: The pill with the imprint 027 R is alprazolam 0.25 mg. Xanax (alprazolam) is a benzodiazepine that works on chemicals in the ... The liquid form of the drug, Alprazolam Intensol, is made by West-Ward Pharmaceuticals.. Alprazolam orally disintegrating ...
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ALPRAZOLAM, 0.25MG, TABLET. Common uses. This medication belongs to the benzodiazepine family. Typically, it is used to reduce ...
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PatientsLikeMe | Evaluations from Patients who take AlprazolamPatientsLikeMe | Evaluations from Patients who take Alprazolam

1 patient evaluation for Alprazolam taken for the purpose of panic attacks with a perceived effectiveness rating of Slight 34 ...
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  • In one study, some long term, high-dosage users of alprazolam developed reversible depression. (wikipedia.org)
  • Absorption of extended release alprazolam is reduced by about one third in patients who eat immediately before taking a dose and increased by the same amount in patients who take an extended release dose on an empty stomach and then eat immediately after. (ems1.com)
  • However, smaller doses may cause dependence if alprazolam is taken longer than 12 weeks. (encyclopedia.com)
  • If you take very high doses or take too much of Alprazolam at once, it can actually be fatal. (ihealthdirectory.com)
  • In high doses, Alprazolam will calm the brain to the point that it becomes so sedated that it slows the breathing and heart rate to fatal levels. (ihealthdirectory.com)
  • Alprazolam should not be used by patients who are pregnant, have narrow angle glaucoma, take ketoconazole or itraconazole, or those who are allergic to this or any other benzodiazepine drug. (encyclopedia.com)
  • Alprazolam should be used under close physician supervision in patients with history of substance abuse. (encyclopedia.com)
  • Patients should discuss with their doctor how to gradually discontinue alprazolam use to avoid such symptoms. (encyclopedia.com)
  • In patients with alcoholic liver disease the half-life of alprazolam ranged between 5.8 and 65.3 hours (mean: 19.7 hours, n = 17) as compared to between 6.3 and 26.9 hours (mean = 11.4 hours, n = 17) in healthy subjects. (nih.gov)
  • Adult and pediatric patients must follow Alprazolam (Xanax) dosing guidelines. (ems1.com)
  • Interestingly, many drug references report clinically significant alterations in distribution and effects of alprazolam when taken with food or in patients who consume grapefruit juice. (ems1.com)
  • Others state that there is a substantial risk of misuse and dependence in both patients and non-medical users and that the high affinity binding, high potency, short elimination half-life, and rapid onset of action may increase the misuse potential of alprazolam. (wikipedia.org)
  • Occasionally alprazolam is used to treat alcohol withdrawal, but it is not FDA-approved for this use, and is not normally the first drug tried in treating alcohol withdrawal symptoms. (encyclopedia.com)
  • Suddenly discontinuing alprazolam after several weeks may cause uncomfortable symptoms of withdrawal. (encyclopedia.com)
  • Withdrawal symptoms in people who have taken alprazolam three months or longer may include seizures , anxiety, nervousness, and headache. (encyclopedia.com)
  • Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. (mayoclinic.org)
  • In the US, alprazolam is FDA-approved for the management of anxiety disorders (a condition corresponding most closely to the APA Diagnostic and Statistical Manual DSM-IV-TR diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. (wikipedia.org)
  • The use of alprazolam during pregnancy is associated with congenital abnormalities, and use in the last trimester may cause fetal drug dependence and withdrawal symptoms in the post-natal period as well as neonatal flaccidity and respiratory problems. (wikipedia.org)
  • Alprazolam, sold under the brand name Xanax, is indicated for the management of anxiety disorder or the short-term relief of symptoms of anxiety. (dmoztools.net)
  • Such low concentrations and the lesser potencies of 4-hydroxyalprazolam and α-hydroxyalprazolam suggest that they are unlikely to contribute much to the pharmacological effects of alprazolam. (nih.gov)
  • See the full alprazolam side effects document. (drugs.com)
  • There are a number of different side effects associated with Alprazolam. (ihealthdirectory.com)
  • There are some other somewhat common side effects to Alprazolam. (ihealthdirectory.com)
  • Remember that if you abuse Alprazolam, you will have to deal with a number of other side effects. (ihealthdirectory.com)
  • Alprazolam may also be indicated for the treatment of generalized anxiety disorder, as well as for the treatment of anxiety conditions with co-morbid depression. (wikipedia.org)
  • Anxiety associated with depression is responsive to alprazolam. (wikipedia.org)
  • However, the research into antidepressant properties of alprazolam is poor and has only assessed its short-term effects against depression. (wikipedia.org)
  • Alprazolam is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds. (nih.gov)
  • The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4 H - s -triazolo [4,3-α] [1,benzodiazepine. (nih.gov)
  • Some of the available data also suggested that lorazepam and alprazolam are more diazepam-like in having relatively high abuse liability, while oxazepam, halazepam, and possibly chlordiazepoxide, are relatively low in this regard. (wikipedia.org)
  • Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. (mayoclinic.org)
  • The dose of alprazolam must be carefully regulated and individualized in the elderly (over age 60), people with liver or kidney disease, and those taking other medications used to treat mental disorders. (encyclopedia.com)
  • A mean half-life of alprazolam of 16.3 hours has been observed in healthy elderly subjects (range: 9 to 26.9 hours, n = 16) compared to 11 hours (range: 6.3 to 15.8 hours, n = 16) in healthy adult subjects. (nih.gov)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. (mayoclinic.org)
  • 33 additional evaluations for Alprazolam are not currently shared publicly. (patientslikeme.com)
  • Because alprazolam is a nervous system and respiratory depressant, it should not be taken with other similar depressants, such as alcohol, other sedatives, sleeping pills, or tranquilizers. (encyclopedia.com)
  • The neurotransmitter GABA, when bound to the GABA receptor, mediates the calming or inhibitory effects of alprazolam on the nervous system. (nih.gov)
  • Alprazolam works by slowing down the brain (central nervous system). (medbroadcast.com)
  • Alprazolam may be habit-forming when taken for long periods of time. (medbroadcast.com)
  • 9th most commonly prescribed drug between 2002 - 2009 (U.S.). ClinCalc ranks Alprazolam as 23rd most commonly prescribed drug in 2014 (U.S. (ems1.com)
  • In the United States alprazolam is sold under brand name Xanax. (encyclopedia.com)
  • other drug companies make generic alprazolam extended-release tablets, too. (everydayhealth.com)
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  • Alprazolam oral liquid syrup can be prepared by a compounding pharmacy and is normally concentrated at 1 milligram per milliliter of liquid. (ems1.com)
  • Alprazolam is no longer recommended in Australia for the treatment of panic disorder due to concerns regarding tolerance, dependence, and abuse. (wikipedia.org)
  • Alprazolam is recommended by the World Federation of Societies of Biological Psychiatry (WFSBP) for treatment-resistant cases of panic disorder where there is no history of tolerance or dependence. (wikipedia.org)
  • however, they can also occur or be worse when abusing Alprazolam or if you stop taking Alprazolam suddenly. (ihealthdirectory.com)
  • Erythromycin øger AUC for alprazolam med ca. 145% på grund af hæmning af CYP3A4. (medicin.dk)
  • Induktorer af CYP3A4 (fx carbamazepin, rifampicin) kan øge omsætningshastigheden og derved nedsætte den terapeutiske effekt af alprazolam. (medicin.dk)