An opioid analgesic chemically related to and with an action resembling that of MEPERIDINE, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)
Services providing pharmaceutic and therapeutic drug information and consultation.
Printed publications usually having a format with no binding and no cover and having fewer than some set number of pages. They are often devoted to a single subject.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
The teaching or training of patients concerning their own health needs.
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.
A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.
Persons who are enrolled in research studies or who are otherwise the subjects of research.
Laws concerned with manufacturing, dispensing, and marketing of drugs.
A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).
A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to domestic national security.
Administration of a soluble dosage form by placement under the tongue.
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Disorders related or resulting from abuse or mis-use of opioids.
Agents inhibiting the effect of narcotics on the central nervous system.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
A family of hexahydropyridines.
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Duties that are based in ETHICS, rather than in law.
The enactment of laws and ordinances and their regulation by official organs of a nation, state, or other legislative organization. It refers also to health-related laws and regulations in general or for which there is no specific heading.
Payments or services provided under stated circumstances under the terms of an insurance policy. In prepayment programs, benefits are the services the programs will provide at defined locations and to the extent needed.
Laws and regulations, pertaining to the field of medicine, proposed for enactment or enacted by a legislative body.
A psychoanalytic term meaning self-love.
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.
A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors.
The level of governmental organization and function below that of the national or country-wide government.
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
An antihyperlipoproteinemic agent and uricosuric agent.
Procedure in which an anesthetic is injected directly into the spinal cord.
A widely used local anesthetic agent.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

Risk appraisal of narcotic sedation for children. (1/6)

Since the use of narcotics was initially advocated 28 years ago, serious adverse reactions, including fatalities, have been reported. At least four factors appear to contribute to these reactions: multiple drug administration, excessive dosage, inadequate monitoring, and ineffectual emergency care. Because of the relatively high incidence of life-threatening reactions and the complexity of the required emergency care, the routine use of pediatric sedation techniques that require large doses of narcotics cannot be advocated for use in the private office.  (+info)

Effects of variable alphaprodine dose levels on arterial blood gases in rhesus monkeys. (2/6)

The administration of alphaprodine submucosally in doses of 0.5, 1.0, and 1.5 mg/kg to ketaminized rhesus monkeys resulted in Po(2) levels significantly lower than those observed for controls (ketamine only) at the 10 min level. There was a significant increase in Po(2) levels between the 10 and 20 min intervals, thereafter, Po(2) levels returned toward normal and were not statistically different from baseline. Higher alphaprodine doses (1.0 and 1.5 mg/kg) resulted in a non-significant increase in Pco(2) values. Monitoring Po(2) levels during sedation seems preferable to monitoring Pco(2) in view of the findings of this study.  (+info)

Conscious sedation for minor gynecologic surgery in the ambulatory patient. A pilot study. (3/6)

A conscious sedation regimen consisting of alphaprodine, hydroxyzine, and methohexital together with intensive behavior modification was evaluated in an open pilot study for patients undergoing minor gynecologic surgery. This combination was found to result in hemodynamic stability, satisfactory patient compliance, and patient and surgeon acceptance. Patients were unable to recognize words taught to them just after drugs were administered.Electroencephalogram (EEG) changes seen in general anesthesia or deep sedation were not found in the EEG records of a subset of patients. These findings suggest that conscious sedation can provide adequate relief of pain and anxiety for minor gynecologic procedures when local anesthesia can achieve only partial pain relief.  (+info)

The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets. (4/6)

1. The effects of narcotic analgesic and related drugs were studied on the uptake of 5-hydroxytryptamine (5-HT) and (-)-metaraminol by blood platelets.2. The most potent drug in inhibiting the uptake of 5-HT (10 muM) by human platelets was methadone, followed by pentazocine>piminodine approximately pethidine approximately anileridine approximately cyclazocine approximately thebaine > dextropropoxyphene. Alphaprodine, papaverine, apomorphine, nalorphine, codeine, and morphine were almost without effect. Methadone was slightly less active than desipramine, and had 10% of the activity of imipramine under similar conditions. Naloxone did not antagonize the effect of methadone on 5-HT uptake.3. The most potent inhibitor of metaraminol (3 muM) uptake by human platelets was piminodine, followed by pentazocine>/=anileridine>cyclazocine=methadone > dextropropoxyphene approximately thebaine >/= papaverine approximately alphaprodine >pethidine>morphine. The activity of morphine was 1% of that of piminodine. Piminodine was more potent than desipramine and protriptyline under similar conditions. The order of potency of drugs studied in inhibiting the uptake of metaraminol by rabbit platelets was similar to that obtained with human platelets.4. The effects of the analgesics studied on inhibiting uptake of monoamines did not correlate with their pain-relieving properties.  (+info)

Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia. (5/6)

In this article, an attempt has been made to review the use of receptor stimulating pure agonist opioids in anesthesia, especially in patients with cardiovascular disease. Particular emphasis has been placed on the use of opioids in high doses to produce anesthesia, techniques that recently have become popular in cardiovascular anesthesia. A major benefit of opioid anesthesia is the cardiovascular stability obtained during induction and throughout operation, even in patients with severely impaired cardiac function. There is a considerable body of evidence to support this claim when fentanyl is used. Anesthetic doses of morphine are associated with a higher incidence of cardiovascular disturbances and other problems, and, therefore, more attention to detail is required in order to achieve adequate anesthesia and hemodynamic stability. Although other opioids have been used as sole or principal agents in anesthesia for cardiovascular surgery, none have gained widespread acceptance. Meperidine, for example, which is widely used in lower (nonanesthetic) doses as a supplement to nitrous oxide in cardiac and noncardiac surgery, has proved unsuitable because of severe hemodynamic disturbances when high doses are given. However, initial reports concerning two of the newer agonist opioids, sufentanil and alfentanil, suggest that they may prove to be suitable alternatives and perhaps provide advantages over morphine and fentanyl in patients with or without cardiovascular disease. Although cardiovascular stability usually can be assured in the chronically sick cardiac patient with opioid anesthesia, this is not always so with the healthier patient, particularly those presenting for coronary artery surgery. A frequently occurring problem in these patients is hypertension during or after sternotomy, which can result in myocardial ischemia and infarction. The incidence of severe hypertension (increases in systolic blood pressure greater than 20% of control values) can be reduced drastically by increasing the dose of opioid, e.g., up to 140 micrograms/kg of fentanyl. However, despite such large doses, some patients will continue to need treatment with vasodilators, inhalation anesthetics, or other supplements at certain periods during cardiovascular operations. The use of very large doses of opioids also will prolong postoperative respiratory depression. High doses of opioids can reduce or prevent the hormonal and metabolic responses to the stress of surgery. However, even very large doses of fentanyl or its newer analogues do not prevent marked increases in plasma catecholamine concentrations in response to cardiopulmonary bypass.(ABSTRACT TRUNCATED AT 400 WORDS)  (+info)

Neonatal neurobehavioral effects of inhalation analgesia for vaginal delivery. (6/6)

The authors studied the neonatal neurobehavioral effects of nitrous oxide:oxygen and enflurane:oxygen inhalation analgesia for vaginal delivery. Parturients were assigned randomly to receive no inhalation agent (Group 1, n = 21); enflurane, 0.3 to 0.8 per cent, and oxygen (Group 2, n = 22); or nitrous oxide, 30 to 50 per cent, and oxygen (Group 3, n = 18). Infants were tested at 15 min, 2 h, and 24 h of age using the Neurologic and Adaptive Capacity Score (NACS); and at 2 and 24 h using the Early Neonatal Neurobehavioral Scale (ENNS). No significant differences in neurobehavioral status occurred. For all groups, scores tended to be lowest at two hours of age. We conclude that neither enflurane nor nitrous oxide analgesia adversely affects neonatal neurobehavioral status at 15 min, 2 h, or 24 h of age.  (+info)

TY - JOUR. T1 - Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia. AU - Coleman, Maya B.. AU - Glass, Penny. AU - Brown, Judy. AU - Kadom, Nadja. AU - Tsuchida, Tammy. AU - Scafidi, Joseph. AU - Chang, Taeun. AU - Vezina, Gilbert. AU - Massaro, An N.. PY - 2013/9/1. Y1 - 2013/9/1. N2 - Background: Neonatal Encephalopathy (NE) is a prominent cause of infant mortality and neurodevelopmental disability. Hypothermia is an effective neuroprotective therapy for newborns with encephalopathy. Post-hypothermia functional-anatomical correlation between neonatal neurobehavioral abnormalities and brain injury findings on MRI in encephalopathic newborns has not been previously described. Aim: To evaluate the relationship between neonatal neurobehavioral abnormalities and brain injury on magnetic resonance imaging (MRI) in encephalopathic newborns treated with therapeutic hypothermia. Study design: Neonates with hypoxic ischemic encephalopathy ...
0067]The following opiates, opioids, tranquillisers or other narcotics are substances with a psychotropic action, i.e. have a potential of abuse, and hence are preferably not contained in the dosage form according to the invention: alfentanil, allobarbital, allylprodine, alphaprodine, alprazolam, amfepramone, amphetamine, amphetaminil, amobarbital, anileridine, apocodeine, barbital, bemidone, benzylmorphine, bezitramide, bromazepam, brotizolam, buprenorphine, butobarbital, butorphanol, camazepam, carfentanil, cathine/D-norpseudoephedrine, chlordiazepoxide, clobazam clofedanol, clonazepam, clonitazene, clorazepate, clotiazepam, cloxazolam, cocaine, codeine, cyclobarbital, cyclorphan, cyprenorphine, delorazepam, desomorphine, dextromoramide, dextropropoxyphene, dezocine, diampromide, diamorphone, diazepam, dihydrocodeine, dihydromorphine, dihydromorphone, dimenoxadol, dimephetamol, dimethylthiambutene, dioxaphetylbutyrate, dipipanone, dronabinol, eptazocine, estazolam, ethoheptazine, ...
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1939 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, Germany. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as a hydrochloride salt in tablets, as a syrup, or by intramuscular, subcutaneous, or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1975, 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared with ...
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Varicose vein surgeries are routine outpatient procedures, which are often performed under local anaesthesia. The use of local anaesthesia both minimises the risk to patients and is cost effective, however, a number of patients still experience pain during surgery. Surgical teams must therefore decide to administer either a general or local anaesthetic based on their subjective qualitative assessment of patient anxiety and sensitivity to pain, without any means to objectively validate their decision. To this end, we develop a 3-D polynomial surface fit, of physiological metrics and numerical pain ratings from patients, in order to model the link between the modulation of cardiovascular responses and pain in varicose vein surgeries ...
Previous Hospital: Procedures performed: Cardiovascular Anesthesia, Ultrasound Guided Regional Anesthesia. Interests: Perioperative Medicine, Cardiovascular Anesthesia, Pediatric Anesthesia, Medical Education, Ontario Anesthesiologists Beyond the Mask: Choosing Wisely and Chief Subcommittees, OMA.. Papers published and/or awards given. Moretti ME, Caprara D, Coutinho CJ, Bar-Oz B, Berkovitch M, Addis A, Jovanovski E, Schuler-Faccini L, Koren G. Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study. J Allergy Clin Immunol. 2003 Mar; 111(3):479-83.. Rafii B, Coutinho C, Otulakowski G, OBrodovich H. O2 induction of epithelial Na(+) transport requires heme proteins. American Journal of Physiology -Lung Cell & Molecular Physiology. 278(2):L399-406, 2000 Feb. Physician Council for Southlake Foundation. Lecturer, Department of Anesthesia, Faculty of Medicine, University of Toronto. Click Here for Our Team ...
Journal of Cardiovascular Surgery and Heart Diseases is an online, international, peer reviewed journal dedicated entirely to publish the scholarly articles onsurgical treatment, cardiac surgery, vascular surgery, cardiac transplantation, bypass surgery, heart and lung diseases and their surgical treatment procedures which enhances the preexisting knowledge in the related literature for betterment of human life. The primary aim of the Journal of Cardiovascular Surgery and Heart Diseases is education. The journal aims to dissipate current clinical practices and developments in the area of cardiovascular and thoracic surgery. This includes information on cardiovascular epidemiology, aetiopathogenesis, clinical manifestation etc. The journal accepts manuscripts from cardiovascular anaesthesia, cardiothoracic and vascular nursing and technology development and new/innovative products.
GUIDELINE : Guidelines for the use of cerebral oximetry by near-infrared spectroscopy in cardiovascular anesthesia : a report by the cerebrospinal Division of the Academic Committee of the Japanese Society of Cardiovascular Anesthesiologists (JSCVA) (2019 ...
Possible link between high prenatal BPA levels and neonatal neurobehavioral abnormalities; study advises pregnant women to reduce exposure levels. A new case study examining an infants neurobehavioral abnormalities and extremely high bisphenol A (BPA) concentration of the babys mother suggests a link between the two. The study, Environmental Health Perspectives: A Case Study of High Prenatal Bisphenol A Exposure and Infant Neonatal Neurobehavior, was led by researcher Sheela Sathyanarayana, MD of Seattle Childrens Research Institute, and recently published online in Environmental Health Perspectives.. BPA, a synthetic, man-made chemical, is used in a wide variety of products including: can linings; hard polycarbonate plastics such as baby bottles and reusable cups; and dental sealants. Food may be the single largest source of BPA exposure due to contamination of foods during preparation and processing. BPA has estrogenic (hormone-like) properties. In animal studies, exposure to BPA early in ...
Aramine® (metaraminol bitartrate) has been found in the possession of horse trainers and veterinarians who have been investigated for possible inappropriate drug administration to racing horses. Metaraminol (3-hydroxyphenylisopropanolamine) is a sympathomimetic amine that directly and indirectly affects adrenergic receptors, with alpha effects being predominant. Because it has the potential to affect the performance of a racing horse, its use is prohibited. In the present study, methods for the detection of metaraminol were developed. Metaraminol was found to be extracted with poor recovery (, 50%) from aqueous solutions by routine basic extraction or cation exchange/reversed-phase solid-phase extraction techniques. However, an extractive acetylation method gave good (, 90%) recovery of metaraminol from aqueous samples. Sequential urine samples collected from horses administered metaraminol intramuscularly at 0.02, 0.10, and 0.23 mg/kg were extracted by the developed extractive acetylation ...
Learn about Aramine (Metaraminol) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Friday, January 12, 2018Expand your practice through quality referrals from happy, confident patients who have faced their fears and received excellent care from you and your team!The fear and anxiety experienced by millions of Americans receiving dental care is a well-documented reality. Research suggests nearly 30% of adults would benefit from some form of anxiolysis or sedation to receive dental care. Only 60% of these patients do well with nitrous oxide sedation alone, meaning 34 million fearful individuals are avoiding routine and necessary dental visits.This course is designed to teach you how to take the stress out of dentistry, allowing optimal dental care.Please review your states rulings and codes prior to registering for this course. Minnesota Administrative Rules3100.3600 ADMINISTRATION OF GENERAL ANESTHESIA, DEEP SEDATION, MODERATE SEDATION, MINIMAL SEDATION, AND NITROUS OXIDE INHALATION ANALGESIA.https://www.revisor.mn.gov/rules/?id=3100.3600Wisconsin State LegislatureChapter DE 11
Anesthesiology is the practice of medicine that uses specific drugs to render your entire body-or part of your body-insensitive to pain. Anesthesia will enable you to tolerate a surgical procedure comfortably, with minimal emotional stress. Based upon the type of surgery you are having, among other factors, there are different types of anesthesia.. An anesthesiologist is a doctor of medicine with three or more additional years of specialty training in anesthesia. Anesthesiologists are involved in intensive care, cardiac resuscitation, respiratory therapy and pain treatment. Their primary role, however, is to care for patient needs during surgery or obstetrics, and in the immediate postoperative period.. Overlake Anesthesiologists, P.S., is a team of highly qualified, board-certified physicians who provide anesthesia services at Overlake. Many have additional expertise in obstetric, pediatric and cardiovascular anesthesia. Overlake Anesthesiologists has been administering anesthetics at Overlake ...
The persistence of neurobehavioral effects in female rats (Mol:WIST) exposed to 500 ppm technical xylene (dimethylbenzene, GAS-no 1330-20-7) for 6 hours per day on days 7-20 of prenatal development was studied. The dose level was selected so as not to induce maternal toxicity or decreased viability of offspring. Investigations of learning and memory abilities were performed using a Morris water maze. This task requires rats to spatially navigate, using distal extramaze cues to locate a small platform under the surface of the water in a large pool. At the age of 16 weeks, the exposed offspring showed impairments when the platform was relocated in the pool. Impaired performances after platform relocation were also observed in exposed offspring at 28 and 55 weeks of age, although the difference was not statistically significant at 55 weeks. These data could indicate that the effect was partly reversible, although over a long time period. However, another explanation could be that the animals became ...
Diethelm Wallwiener, Atlas of Gynecologic Surgery, 4th edition English | ISBN: 3136507045 | 2014 | 676 pages | PDF | 68 MB http://nitroflare.com/view/F5A968D
Gynecologic Surgery at Memorial Medical Center. Learn more about our services and how we partner with you to create personalized care.
Womens Health Associates provides many in-office procedures with state of the art equipment to ensure you receive the best quality care
No other journal can match Anesthesia & Analgesia for its original and significant contributions to the anesthesiology field. Each monthly issue features peer-reviewed articles reporting on the latest advances in drugs, preoperative preparation, patient monitoring, pain management, pathophysiology, and many other timely topics. Backed by internationally-known authorities who serve on the Editorial Board and as Section Editors, Anesthesia &Analgesia is your gateway to everything that is happening in anesthesia and 14 related subspecialties: Analgesia; Ambulatory Anesthesia; Anesthetic Pharmacology; Cardiovascular Anesthesia; Critical Care and Trauma; Economics, Education, and Policy; Neurosurgical Anesthesia; Obstetric Anesthesia; Pain Mechanisms; Pain Medicine; Pediatric Anesthesia; Regional Anesthesia; Patient Safety; and Technology, Computing and Simulation.
No other journal can match Anesthesia & Analgesia for its original and significant contributions to the anesthesiology field. Each monthly issue features peer-reviewed articles reporting on the latest advances in drugs, preoperative preparation, patient monitoring, pain management, pathophysiology, and many other timely topics. Backed by internationally-known authorities who serve on the Editorial Board and as Section Editors, Anesthesia &Analgesia is your gateway to everything that is happening in anesthesia and 14 related subspecialties: Analgesia; Ambulatory Anesthesia; Anesthetic Pharmacology; Cardiovascular Anesthesia; Critical Care and Trauma; Economics, Education, and Policy; Neurosurgical Anesthesia; Obstetric Anesthesia; Pain Mechanisms; Pain Medicine; Pediatric Anesthesia; Regional Anesthesia; Patient Safety; and Technology, Computing and Simulation.
Turkish Journal of Thoracic and Cardiovascular Surgery published orginal papers on topics in cardiovascular surgery, cardiovascular anesthesia,cardiology and thoracic surgery. These encompass all relevant clinical, surgical and laboratory specialities, editorials, current and collective reviews, tecnical knowhow papers, case reports, How to Do It papers. All copyrights of the articles that published or will be published belongs to Turkish Journal of Thoracic and Cardiovascular Surgery and without permission of editorial board whole articles or any part of articles table pictures and graphics could not be published. Turkish Journal of Thoracic and Cardiovascular Surgery is indexed by Science Citation Index - Expanded (SCIE). Editor of the Journal of Turkish Thoracic and Cardiovascular Surgery Ataşehir Mah. Ataşehir Bulvarı 48 Ada Mimoza 2-2 K:2 D:6 Ataşehir - İSTANBUL - TURKEY Phone: +90 216 456 14 54 , GSM: 0549 456 14 54 , e - Mail : [email protected] www.tkdcd.org. ...
Turkish Journal of Thoracic and Cardiovascular Surgery published orginal papers on topics in cardiovascular surgery, cardiovascular anesthesia,cardiology and thoracic surgery. These encompass all relevant clinical, surgical and laboratory specialities, editorials, current and collective reviews, tecnical knowhow papers, case reports, How to Do It papers. All copyrights of the articles that published or will be published belongs to Turkish Journal of Thoracic and Cardiovascular Surgery and without permission of editorial board whole articles or any part of articles table pictures and graphics could not be published. Turkish Journal of Thoracic and Cardiovascular Surgery is indexed by Science Citation Index - Expanded (SCIE). Editor of the Journal of Turkish Thoracic and Cardiovascular Surgery Ataşehir Mah. Ataşehir Bulvarı 48 Ada Mimoza 2-2 K:2 D:6 Ataşehir - İSTANBUL - TURKEY Phone: +90 216 456 14 54 , GSM: 0549 456 14 54 , e - Mail : [email protected] www.tkdcd.org. ...
Dr. Thomas Ebert is a Professor of Anesthesiology and serves as the Vice Chairman for Education and Residency Program Director for the Department of Anesthesiology, Medical College of Wisconsin (MCW). He is a staff anesthesiologist at the Zablocki VA Medical Center, Milwaukee, where he also serves as Chief of Anesthesiology. Dr. Ebert did his graduate training at MCW, receiving his masters and doctor of philosophy degrees for his work on the effect of age and cardiovascular disease on human baroreflexes. He has done extensive research in the field of cardiovascular anesthesia and autonomic control during anesthesia. Other research interests include obstructive sleep apnea in surgical patients and anesthetic protection from ischemia/reperfusion injury in young, human volunteers. Currently, he is seeking funding to explore the use of diet and exercise to improve the physical status of frail patients prior to elective surgery to reduce post-surgery adverse events. He has published nearly 125 ...
17th AAGL International Congress on Minimally Invasive Gynecologic Surgery In affiliation with the Indian Association of Gynecologic ...
Minimally Invasive Laparoscopic Gynecologic Surgery - Minimally invasive surgery offers the best possible results with a shorter period of recovery and a lower risk for complications. For minimally invasive
Metaraminol, L-1-(3-hidroksifenil)-2-aminopropan-1-ol, se može sintetisati na dva načina. Prvi način je sinteza počevši od 3-hidroksipropiofenona. Hidroksilna grupa se zaštiti alkilacijom sa benzil hloridom, dajući 3-benziloksipropiofenon. Nakon reakcije sa butil nitritom, dolazi do nitrozilacije u izonitrozoketon, koji se redukcijom vodonikom na Rejnijevem niklu pretvara u 1-(3-benziloksifenil)-2-aminopropan-1-ol, i zatim se zaštitna benzil grupa uklanja redukcijom koristeći vodonik sa paladijumskim katalizatorom, čime se formira racemski metaraminol. Željeni L-izomer se izoluje uz pomoć (+)-tartarinske kiseline.[9][10] ...
Contact info of Joting Spring Machine Co., Ltd.,Taiwan Manufacturer,supplier and exporter of spring machine,cnc spring machine,Spring Former,Spring Length Gage
Turkish Journal of Thoracic and Cardiovascular Surgery published orginal papers on topics in cardiovascular surgery, cardiovascular anesthesia,cardiology and thoracic surgery. These encompass all relevant clinical, surgical and laboratory specialities, editorials, current and collective reviews, tecnical knowhow papers, case reports, How to Do It papers. All copyrights of the articles that published or will be published belongs to Turkish Journal of Thoracic and Cardiovascular Surgery and without permission of editorial board whole articles or any part of articles table pictures and graphics could not be published. Turkish Journal of Thoracic and Cardiovascular Surgery is indexed by Science Citation Index - Expanded (SCIE). Editor of the Journal of Turkish Thoracic and Cardiovascular Surgery Ataşehir Mah. Ataşehir Bulvarı 48 Ada Mimoza 2-2 K:2 D:6 Ataşehir - İSTANBUL - TURKEY Phone: +90 216 456 14 54 , e - Mail : [email protected] www.tkdcd.org. ...
Thomas W. Feeley, M.D. is a Senior Fellow at the Harvard Business School and Professor Emeritus at the University of Texas MD Anderson Cancer Center in Houston, Texas. For twenty years he was the Helen Shafer Fly Distinguished Professor of Anesthesiology at the University of Texas MD Anderson Cancer Center. He headed the Institute for Cancer Care Innovation at the University of Texas MD Anderson Cancer Center until 2017 when he joined Harvard Business School full time. Dr. Feeley received both undergraduate and M.D. degrees from Boston University. He received his graduate medical training in anesthesiology and critical care medicine at Beth Israel Deaconess Medical Center (BIDMC), a teaching hospital of Harvard Medical School. He was a faculty member at Stanford University for ninteen years practicing cardiovascular anesthesia and critical care medicine. In 1997 he came to the University of Texas MD Anderson Cancer Center to create and lead the Division of Anesthesiology and Critical Care. He served
The Vanderbilt Gynecological Surgery team treats noncancerous conditions that affect your reproductive system. We use innovative surgical techniques - including those that are minimally invasive - to achieve the best possible results and to reduce the amount of discomfort after surgery. Our goals are to successfully treat your condition, reduce your recovery time and get you back to the life you love as quickly as possible. ...
Visit Healthgrades for information on Dr. Victoria Tai, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
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The proportion of participants who participated in all YST sessions and those who completed all assessments will be computed and compared to those with incomplete data by demographic characteristics. We will model the relationship between adherence and baseline scores of the measures, as well as change in scores. We will also calculate the proportions and 95% confidence intervals of the items that measure program evaluation and intervention to the Clinical Studies Coordinator, nurses and yoga instructor ...
Alle on koottu tukiasemasäteilyn haittoja osoittavia tutkimuksia. Näiden lisäksi on olemassa pienempi joukko tutkimuksia, joissa haittoja ei ole havaittu. Tiedossani ei ole yhtäkään tutkimusta, jossa tukiasemien läheisyys olisi yhdistynyt vähäisempään määrään oireita tai pienempään syöpäriskiin. Lista on päivitetty 29.3.2016. Abdel-Rassoul G, et al. Neurobehavioral effects among inhabitants around mobile phone base stations. Neurotoxicology. 2007;28:434-440. Ackermann…
Page contains details about rhodamine B octadecyl ester perchlorate/poly(vinyl sulfonic acid)/bovine serum albumin nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Thomas W. Feeley, M.D. is a Senior Fellow at the Harvard Business School and Professor Emeritus at the University of Texas MD Anderson Cancer Center in Houston, Texas. For twenty years he was the Helen Shafer Fly Distinguished Professor of Anesthesiology at the University of Texas MD Anderson Cancer Center. He headed the Institute for Cancer Care Innovation at the University of Texas MD Anderson Cancer Center until 2017 when he joined Harvard Business School full time. Dr. Feeley received both undergraduate and M.D. degrees from Boston University. He received his graduate medical training in anesthesiology and critical care medicine at Beth Israel Deaconess Medical Center (BIDMC), a teaching hospital of Harvard Medical School. He was a faculty member at Stanford University for ninteen years practicing cardiovascular anesthesia and critical care medicine. In 1997 he came to the University of Texas MD Anderson Cancer Center to create and lead the Division of Anesthesiology and Critical Care. He served
FDA takes several steps to make the use of laparoscopic power morcellators safer in gynecologic surgeries: grants marketing authorization for updated labeling, releases draft guidance and issues a Safety Communication.
Exposure to manganese (Mn) is associated with neurobehavioral effects. There is disagreement on whether commonly occurring exposures in welding, ferroalloy, and other industrial processes produce neurologically significant neurobehavioral changes representing parkinsonism. A review of methodological issues in the human epidemiological literature on Mn identified: (1) studies focused on idiopathic Parkinson disease without considering manganism, a parkinsonian syndrome; (2) studies with healthy worker effect bias; (3) studies with problematic statistical modeling; and (4) studies arising from case series derived from litigation. Investigations with adequate study design and exposure assessment revealed consistent neurobehavioral effects and attributable subclinical and clinical signs and symptoms of impairment. Twenty-eight studies show an exposure-response relationship between Mn and neurobehavioral effects, including 11 with continuous exposure metrics and six with three or four levels of ...
Ethicon is devoted to shaping the future of surgery by advancing innovation, addressing the most pressing healthcare issues and improving lives every day.
Provides superbly illustrated, authoritative guidance on operative techniques along with a thorough understanding of how to select the best procedure, how to avoid complications, and what outcomes to expect.
We are a comprehensive, full-service practice committed to providing quality health care for women of all ages. Call GYNLA Today.
As an obstetrician and gynecologist, I have an appreciation for health care needs unique to my patients. I love that medical advances over the last five to 10 years have allowed me to help many women with an array of treatment choices, especially related to gynecologic surgery.. Many women consider gynecologic surgery for various conditions, such as abnormal bleeding, pelvic pain, ovarian cysts, fibroids or endometriosis. In the past, these surgeries were often done through large abdominal incisions requiring long hospitalizations and extended recovery time. In addition, they were sometimes accompanied by more scar tissue and increased risks of bleeding and infection.. Thankfully, as with much of modern medicine, an array of minimally invasive surgery techniques now exist to provide women with more choice, convenience and benefits, depending on individual needs. These approaches are usually associated with less pain, quicker recovery, and lower risks of infection and bleeding.. Using a minimally ...
Our doctors at Dignity Health hospitals perform minimally invasive gynecologic surgery, including laparoscopic & hysteroscopic surgery, in AZ.
Berard (1841) and Simon (1869) reported the earliest recorded repairs of ureteral injuries in gynecologic surgery. While the exact details of this procedure are unknown, the ureter and its course were... more
Ecuador is the third largest producer of cut flowers in the world, primarily roses, many of which are destined to be sold for Mothers Day. The industry employs more than 103,000 people, and relies heavily on agricultural pesticides.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.. ...
WellSpan OB/GYN at 3130 Grandview Rd. in Hanover, 17331 offers womens health care needs including gynecology, obstetrics, infertility, gynecologic surgery, family planning and contraception.
The Minimally Invasive Gynecologic Surgery Center at Mass General delivers innovative, multidisciplinary care for a full range of gynecologic conditions.
Ganstigmine (CHF2819) is a novel, orally active acetylcholinesterase inhibitor that induces a stimulation of brain cholinergic transmission. In vivo studies show that, in rat prefrontal cortex, extracellular acetylcholine (ACh) concentrations are significantly increased either after local (1 and 10M) or oral (1.5 and 3 mg/kg) administration. Moreover, repeated oral treatment (six consecutive days; 3 mg/kg) with ganstigmine significantly increases basal extracellular concentrations of ACh in rat prefrontal cortex. Then, acute ganstigmine administration induces a significant increase in extracellular ACh concentrations (actual values) with respect to the last sample in ganstigmine-treated rats. Concentrations of serotonin (5-HT) and noradrenaline (NA) are not affected by any oral dose of ganstigmine (1.5 and 3 mg/kg) used. Moreover, levels of dopamine (DA) and metabolites are not modified either. Basal extracellular concentrations of 5-HT, NA, DA and metabolites are not affected by repeated (six ...
Laura Douglass, MD, specializes in gynecologic surgery, including fertility sparing treatment for endometriosis and transabdominal cerclages (TAC) for women with an incompetent cervix.
Dr. Ljunggren is board certified and practices obstetrics & gynecology, including normal and high risk obstetrics, gynecologic surgery, and well woman care.
Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was ... Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. Alphaprodine is closely related to desomorphine ... and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. Tests in rats showed alphaprodine ... Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route ...
Roberts, H; Kuck, MA (19 November 1960). "Use of alphaprodine and levallorphan during labour". Canadian Medical Association ...
This research produced the analgesic alphaprodine (Nisentil, Prisilidine), a very closely related compound. In 1976, a 23-year- ...
... and somewhat more distantly alphaprodine. Not being in clinical use in the United States, it is a Schedule I Narcotic ...
... does exhibit optical isomerism as do other chemicals of its general type ranging from pethidine and alphaprodine ...
... and alphaprodine (Nisentil). Phenadoxone has a US DEA ACSCN of 9637 and recently has had a zero annual manufacturing quota ...
... allylprodine alphameprodine alphaprodine betameprodine betaprodine desmethylprodine (MPPP) PEPAP trimeperidine Synthetic 4- ...
... acetylmethadol alphacetylmethadol alphameprodine alphamethadol alphamethylfentanyl alphamethylthiofentanyl alphaprodine ...
Alphamul Alphanate AlphaNine SD alphaprodine (INN) Alphaquin HP Alpharedisol Alphatrex Alphazine alpidem (INN) alpiropride (INN ...
Alphaprodine (α-1,3-dimethyl-4-phenyl-4-piperidinol propionate) Anileridine (ethyl 1-[2-(p-aminophenyl)ethyl]-4- ...
... alphaprodine MeSH D03.383.621.050 - anabasine MeSH D03.383.621.080 - betalains MeSH D03.383.621.080.500 - betacyanins MeSH ...
... alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. ...
Alphameprodine Alphamethadol Alphaprodine Anileridine Benzethidine Benzylmorphine (3-benzylmorphine) Betacetylmethadol ...
40 to 60 mg of alphaprodine and 10 mg of morphine. Oral formulations were also available. Piminodine has similar effects to ...
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
... (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi.[1][2][3][4][5][6][7][8] It acts as a competitive, reversible, and non-selective monoamine oxidase inhibitor,[5][6][9] and as a low affinity, non-competitive NMDA receptor antagonist.[1][2][10] A pilot study of indantadol for chronic cough was initiated in October 2009 and in April 2010 it failed to achieve significant efficacy in neuropathic pain in phase IIb clinical trials.[7][8][11][12] ...
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
Drugs that have been introduced for uses other than analgesics are also used in pain management. Both first-generation (such as amitriptyline) and newer anti-depressants (such as duloxetine) are used alongside NSAIDs and opioids for pain involving nerve damage and similar problems. Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or tripelennamine to increase the pain-killing ability of a given dose of opioid analgesic. Adjuvant analgesics, also called atypical analgesics, include nefopam, orphenadrine, pregabalin, gabapentin, cyclobenzaprine, hyoscine (scopolamine), and other drugs possessing anticonvulsant, anticholinergic, and/or antispasmodic properties, as well as many other drugs with CNS actions. These drugs are used along with analgesics to modulate and/or modify the action of opioids when used against pain, especially of neuropathic origin. Dextromethorphan has been noted to slow the development of tolerance to opioids ...
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990). "[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 95 (1): 41-6. doi:10.1254/fpj.95.1_41. PMID 2154395 ...
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
... [1][2] is an opioid analgesic.[3] with a potency ½ that of morphine. It was initially discovered by Russian scientists in 1954 and subsequently rediscovered in the US in 1969.[4] Its LD50 in mice is 83 mg/kg.[5] It has never been marketed commercially, likely due to its low potency and lack of benefits compared to existing agents. ...
... binds to the opioid receptor. During the studies of in vitro inhibition of specific [3H] fentanyl binding to the opioid receptor, the order of analogues was: (±)-cis-3-methylfentanyl , fentanyl = alpha-methylfentanyl , butyrylfentanyl , benzylfentanyl.[2] The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined, revealed order: fentanyl = butyrylfentanyl , (±)-cis-3-methylfentanyl , benzylfentanyl , alpha-methylfentanyl.[2] High cross-reactivity may be the effect of the shape of the molecule - the shape of butyrfentanyl is closest to the original fentanyl molecule, which makes it easy to bind by fentanyl antibodies. The opioid receptor affinity of fentanyl and its analogs was determined from their inhibitory potency in a binding ...
... (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic, a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic. It was first synthesized by Ludwig Knorr in 1887.[1][2]:26-27 Phenazone is synthesized[3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone[4] with dimethyl sulfate or methyl iodide. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours.[5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.[6]. ...
... is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action. Phenyltoloxamine has analgesic and anti-spasmodic properties of its own[citation needed] and is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions. In this respect, it is similar to a closely related antihistamine, orphenadrine, and both drugs are very closely related to diphenhydramine and to doxylamine, the latter of which is the active ingredient in NyQuil and many other cough ...
Class Ib antiarrhythmic agents are sodium channel blockers. They have fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. Class Ib agents shorten the action potential duration and reduce refractoriness. These agents will decrease Vmax in partially depolarized cells with fast response action potentials. They either do not change the action potential duration, or they may decrease the action potential duration. Class Ib drugs tend to be more specific for voltage gated Na channels than Ia. Lidocaine in particular is highly frequency dependent, in that it has more activity with increasing heart rates. This is because lidocaine selectively blocks Na channels in their open and inactive states and has little binding capability in the resting state. Class Ib agents are indicated for the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation. Class Ib ...
... (INN) is a synthetic opioid analgesic related to methadone that was never marketed.[1] In a clinical trial of postpartum patients it was reported to produce analgesia comparable to that of morphine but with less nausea, dizziness, and drowsiness.[2][3] Other side effects included salivation, ataxia, and respiratory depression that was reversible by naloxone.[2][3] Similarly to many of its analogues, noracymethadol is a Schedule I controlled substance in the United States with an ACSCN of 9633 and 2013 annual manufacturing quota of 12 grammes. [4] and is also controlled internationally under the United Nations Single Convention on Narcotic Drugs of 1961.[5] The salts known are the gluconate (free base conversion ratio 0.633) and hydrochloride (0.903).. Noracymethadol is an acetyl ester of methadol and it can be said with some precision that it is either the heroin or 6-monoacetylmorphine analogue of methadol, and being a methadol it exhibits optical isomerism. The other methadols ...
On June 30, 2009, a U.S. Food and Drug Administration (FDA) advisory panel voted by a narrow margin to advise the FDA to remove Vicodin and another opioid, Percocet, from the market because of "a high likelihood of overdose from prescription narcotics and acetaminophen products".[23] The panel also cited concerns of liver damage from their acetaminophen component, which is also the main ingredient in commonly used nonprescription drugs such as Tylenol.[23] Each year, acetaminophen overdose is linked to about 400 deaths and 42,000 hospitalizations.[24] In January 2011, the FDA asked manufacturers of prescription combination products that contain acetaminophen to limit the amount of acetaminophen to no more than 325 mg in each tablet or capsule within 3 years.[25][26][27][28] The FDA also required manufacturers on all acetaminophen containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic ...
In June 2010, the Medicines and Healthcare products Regulatory Agency of the United Kingdom licensed nabiximols as a prescription-only medicine for the treatment of spasticity due to multiple sclerosis. This regulatory authorization represents the world's first full regulatory approval for the medicine. The spray is being marketed in the UK by Bayer Schering Pharma. Many people with MS cannot receive nabiximols due to local National Health Service (NHS) resistance to its funding;[5][6] but, in August 2014, the NHS in Wales agreed to fund Sativex for people with multiple sclerosis.[7] Nabiximols was also approved in Spain for MS spasticity in the second half of 2010 and was launched in that country in March 2011. It was approved in the Czech Republic in April 2011, in Germany in May 2011, in Denmark in June 2011 and in Sweden in January 2012 to people with MS who have not responded adequately to other medication for spasticity.[8] It has also been recommended for approval in Italy and Austria ...
NOTE: These are controlled substances (opiates): 21 CFR, 1308.11 (betaprodine) and 1308.12 (alphaprodine). ...
ChEMBL Compound Description] ID:, InChI_Key:, Tradenames:NISENTIL, Synonyms:NISENTIL , ALPHAPRODINE , ALPHAPRODINE ... ALPHAPRODINE. ChEMBL Synonyms NISENTIL , ALPHAPRODINE , ALPHAPRODINE HYDROCHLORIDE. Max Phase. 0. Trade Names. ...
Detailed drug Information for Talacen. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Alphaprodine. 25. alpha-Methylfentanyl. 30. alpha-Methylthiofentanyl. 30. alpha-Methyltryptamine (AMT). 25. ...
Alphaprodine. 9010. II. Anileridine. 9020. II. Cocaine. 9041. II. Dihydrocodeine. 9120. II. ...
Alphaprodine. 2. Amobarbital. 40,007. Amphetamine (for conversion). 8,500,000. Amphetamine (for sale). 25,300,000. ...
Article 5.. North Carolina Controlled Substances Act. 90-86. Title of Article.. This Article shall be known and may be cited as the North Carolina Controlled Substances Act. (1971, c. 919, s. 1.). 90-87. Definitions.. As used in this Article:. (1) Administer means the direct application of a controlled substance, whether by injection, inhalation, ingestion, or any other means to the body of a patient or research subject by:. a. A practitioner (or, in his presence, by his authorized agent), or. b. The patient or research subject at the direction and in the presence of the practitioner.. (2) Agent means an authorized person who acts on behalf of or at the direction of a manufacturer, distributor, or dispenser but does not include a common or contract carrier, public warehouseman, or employee thereof.. (3) Bureau means the Bureau of Narcotics and Dangerous Drugs, United States Department of Justice or its successor agency.. (3a) Commission means the Commission for Mental Health, ...
Alphaprodine. 9010. II. Anileridine. 9020. II. Cocaine. 9041. II. Codeine. 9050. II. ...
It is against the law and dangerous for anyone else to use your medicine. Keep your unused films or tablets in a safe and secure place. People who are addicted to drugs might want to steal this medicine. Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, seizures, trouble breathing, and cold, clammy skin. Call your doctor right away if you notice these symptoms. Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Serious unwanted effects can occur if certain medicines are given together with buprenorphine and naloxone combination. This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies ...
Do not take naltrexone and bupropion combination with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking naltrexone and bupropion combination during the 2 weeks after you stop a MAO inhibitor. Wait 2 weeks after stopping naltrexone and bupropion combination before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Do not use naltrexone and bupropion combination if you are also using Zyban® to quit smoking or Aplenzin® or Wellbutrin® for depression, because they also contain bupropion. Also, do not take this medicine if you are using or have used narcotic drugs (such as buprenorphine, methadone, or other habit-forming painkillers) within the past 7 to 10 days. This medicine may cause ...
De tekst is beschikbaar onder de licentie Creative Commons Naamsvermelding-Gelijk delen. Er kunnen aanvullende voorwaarden van toepassing zijn. Zie de Gebruiksvoorwaarden voor meer informatie ...
2. Alphaprodine.. 3. Anileridine.. 4. Bezitramide.. 5. Bulk propoxyphene (nondosage forms).. 6. Carfentanil. ...
Alphaprodine; Anileridine; Bezitramide; Dihydrocodeine; Dihydromorphinone; Diphenoxylate; Fentanyl; Isomethadone; ...
Section 31. For the purposes of establishing criminal penalties for violation of a provision of this chapter, there are established the following five classes of controlled substances: CLASS A (a) Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation: (1) Acetylmethadol (2) Allylprodine (3) Alphacetylmethadol (4) Alphameprodine (5) Alphamethadol (6) Benzethidine (7) Betacetylmethadol (8) Betameprodine (9) Betamethadol (10) Betaprodine (11) Clonitazene (12) Dextromoramide (13) Dextrorphan (14) Diampromide (15) Diethylthiambutene (16) Dimenoxadol (17) Dimepheptanol (18) Dimethylthiambutene (19) Dioxaphetylbutyrate (20) Dipipanone (21) Ethylmethylthiambutene (22) Etonitazene (23) Etoxeridine (24) Furethidine (25) Hydroxypethidine (26) Ketobemidone (27) ...
12 Alphaprodine. 25.0. 25.0. 13 Amphecloral. 2.0. 2.0. 14 3-(2-Aminopropyl)indole (alpha-methyltryptamine (AMT)). 2.0. 2.0. ...
2) Alphaprodine 9010. (3) Anileridine 9020. (4) Bezitramide 9800. (5) Bulk dextropropoxyphene (nondosage forms) 9273 ...
Alphaprodine. 3. 3. Amobarbital. 9. 25,125. +25,116. Amphetamine (for conversion). 18,375,000. 21,875,000. +3,500,000. ...
Alphaprodine. α-1,3-dimetil-4-fenil-4-propionoksipiperidin. α-1,3-dimethyl-4-phenyl-4-propionoxypiperidine ...
Alphaprodine. a-1,3-dimethyl-4-phenyl-4-propionoxypiperidine. anileridin. Anileridine. 1-p-aminophenethyl-4-phenylpiperidine-4- ...
1 gm of Alphaprodine =. 100 gm of marihuana. 1 gm of Fentanyl (N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl] Propanamide) =. 2.5 ...
2) Alphaprodine;. (3) Anileridine;. (4) Bezitramide;. (5) Bulk Dextropropoxyphene (nondosage form);. (6) Carfentanil; ...
Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was ... Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. Alphaprodine is closely related to desomorphine ... and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. Tests in rats showed alphaprodine ... Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route ...
The electronic Irish Statute Book (eISB) comprises the Acts of the Oireachtas (Parliament), Statutory Instruments, Legislation Directory, Constitution and a limited number of pre-1922 Acts.
Alphaprodine. The risk or severity of adverse effects can be increased when Cinchocaine is combined with Alphaprodine.. Illicit ...
This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
Roberts, H; Kuck, MA (19 November 1960). "Use of alphaprodine and levallorphan during labour". Canadian Medical Association ...
2. Alphaprodine.. 3. Anileridine.. 4. Bezitramide.. 5. Bulk propoxyphene (nondosage forms).. 6. Carfentanil. ...
2. Alphaprodine.. 3. Anileridine.. 4. Bezitramide.. 5. Bulk propoxyphene (nondosage forms).. 6. Carfentanil. ...
a) by inserting "(3-Amino-2,2-dimethylpropyl) 4-aminobenzoate (otherwise known as Desethyl dimethocaine)." after "Alphaprodine ...
  • Four analgesic drugs (morphine, levorphan, alphaprodine, dihydrocodeine) and 2 analgesic-antagonists (nalorphine, levallorphan) were studied for their effects on intestinal motility in vitro and in vivo . (aspetjournals.org)
  • 3) Dihydrocodeine and alphaprodine exhibited approximately [unknown] the intestinal spasmogenic potency of morphine. (aspetjournals.org)
  • Alphaprodine was sold under several brand names, mainly Nisentil and Prisilidine. (wikipedia.org)
  • Tests in rats showed alphaprodine to be 97% the strength of morphine via the subcutaneous route and 140% the strength of methadone orally. (wikipedia.org)
  • Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route. (wikipedia.org)
  • 21 CFR, 1308.11 (betaprodine) and 1308.12 (alphaprodine). (drugfuture.com)
  • There are two isomers of the trans form of prodine, alphaprodine and betaprodine. (wikipedia.org)
  • Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. (wikipedia.org)
  • Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was developed for medicinal use. (wikipedia.org)
  • Betaprodine produces more euphoria and side effects than alphaprodine at all dose levels, and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. (wikipedia.org)
  • other somewhat more distant relatives include alphaprodine and piritramide. (metakraft.de)
  • Also, the drug is a distant relative of alphaprodine and piritramide. (rehabnear.me)
  • Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc. ), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. (psychonautwiki.org)
  • Also, the drug is a distant relative of alphaprodine and piritramide. (rehabnear.me)