Alphaprodine
An opioid analgesic chemically related to and with an action resembling that of MEPERIDINE, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)
Drug Information Services
Pamphlets
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Formularies as Topic
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Drug Industry
Medical Records Systems, Computerized
Drug and Narcotic Control
United States Department of Agriculture
A cabinet department in the Executive Branch of the United States Government concerned with improving and maintaining farm income and developing and expanding markets for agricultural products. Through inspection and grading services it safeguards and insures standards of quality in food supply and production.
Research Subjects
Methyltestosterone
United States Department of Homeland Security
Buprenorphine
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Naloxone
Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Emergency Treatment
Copyright
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Receptors, Phencyclidine
Specific sites or molecular structures on cell membranes or in cells with which phencyclidine reacts or to which it binds to elicit the specific response of the cell to phencyclidine. Studies have demonstrated the presence of multiple receptor sites for PCP. These are the PCP/sigma site, which binds both PCP and psychotomimetic opiates but not certain antipsychotics, and the PCP site, which selectively binds PCP analogs.
Receptors, sigma
A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.
Phencyclidine
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
Stereoisomerism
Decision Making
Legislation as Topic
Insurance Benefits
Legislation, Medical
Opium
The air-dried exudate from the unripe seed capsule of the opium poppy, Papaver somniferum, or its variant, P. album. It contains a number of alkaloids, but only a few - MORPHINE; CODEINE; and PAPAVERINE - have clinical significance. Opium has been used as an analgesic, antitussive, antidiarrheal, and antispasmodic.
Dextrorphan
Ethylmorphine
Hydrocodone
Nalbuphine
State Government
Anesthetics, Local
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Dibucaine
Risk appraisal of narcotic sedation for children. (1/6)
Since the use of narcotics was initially advocated 28 years ago, serious adverse reactions, including fatalities, have been reported. At least four factors appear to contribute to these reactions: multiple drug administration, excessive dosage, inadequate monitoring, and ineffectual emergency care. Because of the relatively high incidence of life-threatening reactions and the complexity of the required emergency care, the routine use of pediatric sedation techniques that require large doses of narcotics cannot be advocated for use in the private office. (+info)Effects of variable alphaprodine dose levels on arterial blood gases in rhesus monkeys. (2/6)
The administration of alphaprodine submucosally in doses of 0.5, 1.0, and 1.5 mg/kg to ketaminized rhesus monkeys resulted in Po(2) levels significantly lower than those observed for controls (ketamine only) at the 10 min level. There was a significant increase in Po(2) levels between the 10 and 20 min intervals, thereafter, Po(2) levels returned toward normal and were not statistically different from baseline. Higher alphaprodine doses (1.0 and 1.5 mg/kg) resulted in a non-significant increase in Pco(2) values. Monitoring Po(2) levels during sedation seems preferable to monitoring Pco(2) in view of the findings of this study. (+info)Conscious sedation for minor gynecologic surgery in the ambulatory patient. A pilot study. (3/6)
A conscious sedation regimen consisting of alphaprodine, hydroxyzine, and methohexital together with intensive behavior modification was evaluated in an open pilot study for patients undergoing minor gynecologic surgery. This combination was found to result in hemodynamic stability, satisfactory patient compliance, and patient and surgeon acceptance. Patients were unable to recognize words taught to them just after drugs were administered.Electroencephalogram (EEG) changes seen in general anesthesia or deep sedation were not found in the EEG records of a subset of patients. These findings suggest that conscious sedation can provide adequate relief of pain and anxiety for minor gynecologic procedures when local anesthesia can achieve only partial pain relief. (+info)The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets. (4/6)
1. The effects of narcotic analgesic and related drugs were studied on the uptake of 5-hydroxytryptamine (5-HT) and (-)-metaraminol by blood platelets.2. The most potent drug in inhibiting the uptake of 5-HT (10 muM) by human platelets was methadone, followed by pentazocine>piminodine approximately pethidine approximately anileridine approximately cyclazocine approximately thebaine > dextropropoxyphene. Alphaprodine, papaverine, apomorphine, nalorphine, codeine, and morphine were almost without effect. Methadone was slightly less active than desipramine, and had 10% of the activity of imipramine under similar conditions. Naloxone did not antagonize the effect of methadone on 5-HT uptake.3. The most potent inhibitor of metaraminol (3 muM) uptake by human platelets was piminodine, followed by pentazocine>/=anileridine>cyclazocine=methadone > dextropropoxyphene approximately thebaine >/= papaverine approximately alphaprodine >pethidine>morphine. The activity of morphine was 1% of that of piminodine. Piminodine was more potent than desipramine and protriptyline under similar conditions. The order of potency of drugs studied in inhibiting the uptake of metaraminol by rabbit platelets was similar to that obtained with human platelets.4. The effects of the analgesics studied on inhibiting uptake of monoamines did not correlate with their pain-relieving properties. (+info)Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia. (5/6)
In this article, an attempt has been made to review the use of receptor stimulating pure agonist opioids in anesthesia, especially in patients with cardiovascular disease. Particular emphasis has been placed on the use of opioids in high doses to produce anesthesia, techniques that recently have become popular in cardiovascular anesthesia. A major benefit of opioid anesthesia is the cardiovascular stability obtained during induction and throughout operation, even in patients with severely impaired cardiac function. There is a considerable body of evidence to support this claim when fentanyl is used. Anesthetic doses of morphine are associated with a higher incidence of cardiovascular disturbances and other problems, and, therefore, more attention to detail is required in order to achieve adequate anesthesia and hemodynamic stability. Although other opioids have been used as sole or principal agents in anesthesia for cardiovascular surgery, none have gained widespread acceptance. Meperidine, for example, which is widely used in lower (nonanesthetic) doses as a supplement to nitrous oxide in cardiac and noncardiac surgery, has proved unsuitable because of severe hemodynamic disturbances when high doses are given. However, initial reports concerning two of the newer agonist opioids, sufentanil and alfentanil, suggest that they may prove to be suitable alternatives and perhaps provide advantages over morphine and fentanyl in patients with or without cardiovascular disease. Although cardiovascular stability usually can be assured in the chronically sick cardiac patient with opioid anesthesia, this is not always so with the healthier patient, particularly those presenting for coronary artery surgery. A frequently occurring problem in these patients is hypertension during or after sternotomy, which can result in myocardial ischemia and infarction. The incidence of severe hypertension (increases in systolic blood pressure greater than 20% of control values) can be reduced drastically by increasing the dose of opioid, e.g., up to 140 micrograms/kg of fentanyl. However, despite such large doses, some patients will continue to need treatment with vasodilators, inhalation anesthetics, or other supplements at certain periods during cardiovascular operations. The use of very large doses of opioids also will prolong postoperative respiratory depression. High doses of opioids can reduce or prevent the hormonal and metabolic responses to the stress of surgery. However, even very large doses of fentanyl or its newer analogues do not prevent marked increases in plasma catecholamine concentrations in response to cardiopulmonary bypass.(ABSTRACT TRUNCATED AT 400 WORDS) (+info)Neonatal neurobehavioral effects of inhalation analgesia for vaginal delivery. (6/6)
The authors studied the neonatal neurobehavioral effects of nitrous oxide:oxygen and enflurane:oxygen inhalation analgesia for vaginal delivery. Parturients were assigned randomly to receive no inhalation agent (Group 1, n = 21); enflurane, 0.3 to 0.8 per cent, and oxygen (Group 2, n = 22); or nitrous oxide, 30 to 50 per cent, and oxygen (Group 3, n = 18). Infants were tested at 15 min, 2 h, and 24 h of age using the Neurologic and Adaptive Capacity Score (NACS); and at 2 and 24 h using the Early Neonatal Neurobehavioral Scale (ENNS). No significant differences in neurobehavioral status occurred. For all groups, scores tended to be lowest at two hours of age. We conclude that neither enflurane nor nitrous oxide analgesia adversely affects neonatal neurobehavioral status at 15 min, 2 h, or 24 h of age. (+info)
Neonatal neurobehavioral abnormalities and MRI brain injury in encephalopathic newborns treated with hypothermia<...
CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS - Patent application
Pethidine - Wikipedia
Cardiovascular Anesthesia and Postop Care | Anesthesiology | ASA Publications
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Gynecologic Surgery
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Registration
Did blood transfusion increase mortality in patients with diabetes undergoing isolated coronary artery bypass graft surgery? A...
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rhodamine B octadecyl ester perchlorate/poly(vinyl sulfonic acid)/bovine serum albumin nanoparticles
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Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel
acetylcholinesterase inhibitor, in rat prefrontal...
Laura A. Douglass, MD - UChicago Medicine
Dr. Chandra Ljunggren - Lincoln OB/GYN
Prodine
Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was ... Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. Alphaprodine is closely related to desomorphine ... and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. Tests in rats showed alphaprodine ... Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route ...
Hilda Roberts (physician)
Roberts, H; Kuck, MA (19 November 1960). "Use of alphaprodine and levallorphan during labour". Canadian Medical Association ...
Desmethylprodine
This research produced the analgesic alphaprodine (Nisentil, Prisilidine), a very closely related compound. In 1976, a 23-year- ...
Piritramide
... and somewhat more distantly alphaprodine. Not being in clinical use in the United States, it is a Schedule I Narcotic ...
Phenindamine
... does exhibit optical isomerism as do other chemicals of its general type ranging from pethidine and alphaprodine ...
Phenadoxone
... and alphaprodine (Nisentil). Phenadoxone has a US DEA ACSCN of 9637 and recently has had a zero annual manufacturing quota ...
Single Convention on Narcotic Drugs
... allylprodine alphameprodine alphaprodine betameprodine betaprodine desmethylprodine (MPPP) PEPAP trimeperidine Synthetic 4- ...
Opium Law
... acetylmethadol alphacetylmethadol alphameprodine alphamethadol alphamethylfentanyl alphamethylthiofentanyl alphaprodine ...
List of drugs: Al
Alphamul Alphanate AlphaNine SD alphaprodine (INN) Alphaquin HP Alpharedisol Alphatrex Alphazine alpidem (INN) alpiropride (INN ...
Controlled Drugs and Substances Act
Alphaprodine (α-1,3-dimethyl-4-phenyl-4-piperidinol propionate) Anileridine (ethyl 1-[2-(p-aminophenyl)ethyl]-4- ...
List of MeSH codes (D03)
... alphaprodine MeSH D03.383.621.050 - anabasine MeSH D03.383.621.080 - betalains MeSH D03.383.621.080.500 - betacyanins MeSH ...
Pethidine
... alphaprodine, MPPP, etc.), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. ...
Misuse of Drugs Act 1977
Alphameprodine Alphamethadol Alphaprodine Anileridine Benzethidine Benzylmorphine (3-benzylmorphine) Betacetylmethadol ...
Piminodine
40 to 60 mg of alphaprodine and 10 mg of morphine. Oral formulations were also available. Piminodine has similar effects to ...
A-366,833
Ji, Jianguo; Bunnelle, William H.; Anderson, David J.; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K.; Rueter, Lynne E.; Curzon, Peter; Buckley, Michael J.; Marsh, Kennan C.; Kempf-Grote, Anita; Meyer, Michael D. (2007). "A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253-1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775 ...
Indantadol
... (CHF-3381, V-3381) is a drug which was formerly being investigated as an anticonvulsant and neuroprotective and is now under development for the treatment of neuropathic pain and chronic cough in Europe by Vernalis and Chiesi.[1][2][3][4][5][6][7][8] It acts as a competitive, reversible, and non-selective monoamine oxidase inhibitor,[5][6][9] and as a low affinity, non-competitive NMDA receptor antagonist.[1][2][10] A pilot study of indantadol for chronic cough was initiated in October 2009 and in April 2010 it failed to achieve significant efficacy in neuropathic pain in phase IIb clinical trials.[7][8][11][12] ...
Ketorolac
In the US, ketorolac is the only widely available intravenous NSAID. An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US.[13] The Syntex company, of Palo Alto, California developed the ophthalmic solution Acular[25] around 2006, which is currently licensed by Allergan, Inc.[26][27] In 2007, there were concerns about the high incidence of reported side effects. This led to restriction in its dosage and maximum duration of use. In the UK, treatment was initiated only in a hospital, although this was not designed to exclude its use in prehospital care and mountain rescue settings.[1] Dosing guidelines were published at that time.[28] Concerns over the high incidence of reported side effects with ketorolac trometamol led to its withdrawal (apart from the ophthalmic formulation) in several countries, while in others its permitted dosage and maximum duration of treatment have been reduced. From 1990 to 1993, 97 reactions with a fatal outcome were ...
Analgesic
Drugs that have been introduced for uses other than analgesics are also used in pain management. Both first-generation (such as amitriptyline) and newer anti-depressants (such as duloxetine) are used alongside NSAIDs and opioids for pain involving nerve damage and similar problems. Other agents directly potentiate the effects of analgesics, such as using hydroxyzine, promethazine, carisoprodol, or tripelennamine to increase the pain-killing ability of a given dose of opioid analgesic. Adjuvant analgesics, also called atypical analgesics, include nefopam, orphenadrine, pregabalin, gabapentin, cyclobenzaprine, hyoscine (scopolamine), and other drugs possessing anticonvulsant, anticholinergic, and/or antispasmodic properties, as well as many other drugs with CNS actions. These drugs are used along with analgesics to modulate and/or modify the action of opioids when used against pain, especially of neuropathic origin. Dextromethorphan has been noted to slow the development of tolerance to opioids ...
Benorilate
... (INN), or benorylate, is an ester-linked codrug of aspirin with paracetamol. It is used as an anti-inflammatory and antipyretic medication. In the treatment of childhood fever, it has been shown to be inferior to paracetamol and aspirin taken separately. In addition, because it is converted to aspirin, benorylate is not recommended in children due to concerns about Reye syndrome.[1] ...
Eptazocine
Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990). "[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 95 (1): 41-6. doi:10.1254/fpj.95.1_41. PMID 2154395 ...
Rofecoxib
The VIGOR (Vioxx GI Outcomes Research) study, conducted by Bombardier, et al., which compared the efficacy and adverse effect profiles of rofecoxib and naproxen, had indicated a significant 4-fold increased risk of acute myocardial infarction (heart attack) in rofecoxib patients when compared with naproxen patients (0.4% vs 0.1%, RR 0.25) over the 12-month span of the study. The elevated risk began during the second month on rofecoxib. There was no significant difference in the mortality from cardiovascular events between the two groups, nor was there any significant difference in the rate of myocardial infarction between the rofecoxib and naproxen treatment groups in patients without high cardiovascular risk. The difference in overall risk was by the patients at higher risk of heart attack, i.e. those meeting the criteria for low-dose aspirin prophylaxis of secondary cardiovascular events (previous myocardial infarction, angina, cerebrovascular accident, transient ischemic attack, or coronary ...
Aspirin
Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionised. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion.[152][153][154] About 50-80% of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.[154] As much as 80% of therapeutic doses of salicylic acid is ...
Dimethylaminopivalophenone
... [1][2] is an opioid analgesic.[3] with a potency ½ that of morphine. It was initially discovered by Russian scientists in 1954 and subsequently rediscovered in the US in 1969.[4] Its LD50 in mice is 83 mg/kg.[5] It has never been marketed commercially, likely due to its low potency and lack of benefits compared to existing agents. ...
Butyrfentanyl
... binds to the opioid receptor. During the studies of in vitro inhibition of specific [3H] fentanyl binding to the opioid receptor, the order of analogues was: (±)-cis-3-methylfentanyl , fentanyl = alpha-methylfentanyl , butyrylfentanyl , benzylfentanyl.[2] The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined, revealed order: fentanyl = butyrylfentanyl , (±)-cis-3-methylfentanyl , benzylfentanyl , alpha-methylfentanyl.[2] High cross-reactivity may be the effect of the shape of the molecule - the shape of butyrfentanyl is closest to the original fentanyl molecule, which makes it easy to bind by fentanyl antibodies. The opioid receptor affinity of fentanyl and its analogs was determined from their inhibitory potency in a binding ...
Phenazone
... (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic, a nonsteroidal anti-inflammatory drug (NSAID) and an antipyretic. It was first synthesized by Ludwig Knorr in 1887.[1][2]:26-27 Phenazone is synthesized[3] by condensation of phenylhydrazine and ethyl acetoacetate under basic conditions and methylation of the resulting intermediate compound 1-phenyl-3-methylpyrazolone[4] with dimethyl sulfate or methyl iodide. It crystallizes in needles which melt at 156 °C. Potassium permanganate oxidizes it to pyridazine tetracarboxylic acid. Phenazone has an elimination half life of about 12 hours.[5] Indication: Used to relieve pain and fever. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.[6]. ...
Phenyltoloxamine
... is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action. Phenyltoloxamine has analgesic and anti-spasmodic properties of its own[citation needed] and is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions. In this respect, it is similar to a closely related antihistamine, orphenadrine, and both drugs are very closely related to diphenhydramine and to doxylamine, the latter of which is the active ingredient in NyQuil and many other cough ...
Sodium channel blocker
Class Ib antiarrhythmic agents are sodium channel blockers. They have fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. Class Ib agents shorten the action potential duration and reduce refractoriness. These agents will decrease Vmax in partially depolarized cells with fast response action potentials. They either do not change the action potential duration, or they may decrease the action potential duration. Class Ib drugs tend to be more specific for voltage gated Na channels than Ia. Lidocaine in particular is highly frequency dependent, in that it has more activity with increasing heart rates. This is because lidocaine selectively blocks Na channels in their open and inactive states and has little binding capability in the resting state. Class Ib agents are indicated for the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation. Class Ib ...
Noracymethadol
... (INN) is a synthetic opioid analgesic related to methadone that was never marketed.[1] In a clinical trial of postpartum patients it was reported to produce analgesia comparable to that of morphine but with less nausea, dizziness, and drowsiness.[2][3] Other side effects included salivation, ataxia, and respiratory depression that was reversible by naloxone.[2][3] Similarly to many of its analogues, noracymethadol is a Schedule I controlled substance in the United States with an ACSCN of 9633 and 2013 annual manufacturing quota of 12 grammes. [4] and is also controlled internationally under the United Nations Single Convention on Narcotic Drugs of 1961.[5] The salts known are the gluconate (free base conversion ratio 0.633) and hydrochloride (0.903).. Noracymethadol is an acetyl ester of methadol and it can be said with some precision that it is either the heroin or 6-monoacetylmorphine analogue of methadol, and being a methadol it exhibits optical isomerism. The other methadols ...
Hydrocodone/paracetamol
On June 30, 2009, a U.S. Food and Drug Administration (FDA) advisory panel voted by a narrow margin to advise the FDA to remove Vicodin and another opioid, Percocet, from the market because of "a high likelihood of overdose from prescription narcotics and acetaminophen products".[23] The panel also cited concerns of liver damage from their acetaminophen component, which is also the main ingredient in commonly used nonprescription drugs such as Tylenol.[23] Each year, acetaminophen overdose is linked to about 400 deaths and 42,000 hospitalizations.[24] In January 2011, the FDA asked manufacturers of prescription combination products that contain acetaminophen to limit the amount of acetaminophen to no more than 325 mg in each tablet or capsule within 3 years.[25][26][27][28] The FDA also required manufacturers on all acetaminophen containing products to issue a black box warning indicating the potential risk for severe liver injury and a warning highlighting potential for allergic ...
Nabiximols
In June 2010, the Medicines and Healthcare products Regulatory Agency of the United Kingdom licensed nabiximols as a prescription-only medicine for the treatment of spasticity due to multiple sclerosis. This regulatory authorization represents the world's first full regulatory approval for the medicine. The spray is being marketed in the UK by Bayer Schering Pharma. Many people with MS cannot receive nabiximols due to local National Health Service (NHS) resistance to its funding;[5][6] but, in August 2014, the NHS in Wales agreed to fund Sativex for people with multiple sclerosis.[7] Nabiximols was also approved in Spain for MS spasticity in the second half of 2010 and was launched in that country in March 2011. It was approved in the Czech Republic in April 2011, in Germany in May 2011, in Denmark in June 2011 and in Sweden in January 2012 to people with MS who have not responded adequately to other medication for spasticity.[8] It has also been recommended for approval in Italy and Austria ...
Alphaprodine
Compound Report Card
Talacen Advanced Patient Information - Drugs.com
Federal Register
::
Proposed Aggregate Production Quotas for Schedule I and II Controlled Substances and...
2018 - United States Pharmacopeial Convention
Federal Register
::
Controlled Substances: Proposed Aggregate Production Quotas for 2012
Chapter 90 - Article 5
Article 5.. North Carolina Controlled Substances Act. 90-86. Title of Article.. This Article shall be known and may be cited as the North Carolina Controlled Substances Act. (1971, c. 919, s. 1.). 90-87. Definitions.. As used in this Article:. (1) Administer means the direct application of a controlled substance, whether by injection, inhalation, ingestion, or any other means to the body of a patient or research subject by:. a. A practitioner (or, in his presence, by his authorized agent), or. b. The patient or research subject at the direction and in the presence of the practitioner.. (2) Agent means an authorized person who acts on behalf of or at the direction of a manufacturer, distributor, or dispenser but does not include a common or contract carrier, public warehouseman, or employee thereof.. (3) Bureau means the Bureau of Narcotics and Dangerous Drugs, United States Department of Justice or its successor agency.. (3a) Commission means the Commission for Mental Health, ...
2018 - Lipomed
Buprenorphine/Naloxone (Oromucosal Route, Sublingual Route) Precautions - Mayo Clinic
It is against the law and dangerous for anyone else to use your medicine. Keep your unused films or tablets in a safe and secure place. People who are addicted to drugs might want to steal this medicine. Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, seizures, trouble breathing, and cold, clammy skin. Call your doctor right away if you notice these symptoms. Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Serious unwanted effects can occur if certain medicines are given together with buprenorphine and naloxone combination. This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies ...
Naltrexone And Bupropion (Oral Route) Description and Brand Names - Mayo Clinic
Do not take naltrexone and bupropion combination with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking naltrexone and bupropion combination during the 2 weeks after you stop a MAO inhibitor. Wait 2 weeks after stopping naltrexone and bupropion combination before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may have confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Do not use naltrexone and bupropion combination if you are also using Zyban® to quit smoking or Aplenzin® or Wellbutrin® for depression, because they also contain bupropion. Also, do not take this medicine if you are using or have used narcotic drugs (such as buprenorphine, methadone, or other habit-forming painkillers) within the past 7 to 10 days. This medicine may cause ...
Category:Piperidines - Wikimedia Commons
Chapter 893 Section 03 - 2011 Florida Statutes - The Florida Senate
Sec. 152.02 MN Statutes
Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem
General Law - Part I, Title XV, Chapter 94C, Section 31
Section 31. For the purposes of establishing criminal penalties for violation of a provision of this chapter, there are established the following five classes of controlled substances: CLASS A (a) Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation: (1) Acetylmethadol (2) Allylprodine (3) Alphacetylmethadol (4) Alphameprodine (5) Alphamethadol (6) Benzethidine (7) Betacetylmethadol (8) Betameprodine (9) Betamethadol (10) Betaprodine (11) Clonitazene (12) Dextromoramide (13) Dextrorphan (14) Diampromide (15) Diethylthiambutene (16) Dimenoxadol (17) Dimepheptanol (18) Dimethylthiambutene (19) Dioxaphetylbutyrate (20) Dipipanone (21) Ethylmethylthiambutene (22) Etonitazene (23) Etoxeridine (24) Furethidine (25) Hydroxypethidine (26) Ketobemidone (27) ...
Legal database - View: Principal legislation: SECTION 314.2
Statute | Kansas State Legislature
DEA Establishes Production Limits for Painkillers, With Some Drugs Set for Big Increases | RAPS
Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...
Popis opojnih droga, psihotropnih tvari i biljaka iz kojih se može dobiti opojna droga te tvari koje se mogu uporabiti za...
2016 Chapter 2 D | United States Sentencing Commission
SB2745.DOC
Prodine - Wikipedia
Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was ... Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. Alphaprodine is closely related to desomorphine ... and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. Tests in rats showed alphaprodine ... Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route ...
Misuse of Drugs Act, 1977, Schedule
Cinchocaine - DrugBank
Meyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo
Hilda Roberts (physician) - Wikipedia
Flsenate Archive: Statutes & Constitution
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Dihydrocodeine2
- Four analgesic drugs (morphine, levorphan, alphaprodine, dihydrocodeine) and 2 analgesic-antagonists (nalorphine, levallorphan) were studied for their effects on intestinal motility in vitro and in vivo . (aspetjournals.org)
- 3) Dihydrocodeine and alphaprodine exhibited approximately [unknown] the intestinal spasmogenic potency of morphine. (aspetjournals.org)
NISENTIL1
- Alphaprodine was sold under several brand names, mainly Nisentil and Prisilidine. (wikipedia.org)
Morphine2
- Tests in rats showed alphaprodine to be 97% the strength of morphine via the subcutaneous route and 140% the strength of methadone orally. (wikipedia.org)
- Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine via the subcutaneous route. (wikipedia.org)
Betaprodine5
- 21 CFR, 1308.11 (betaprodine) and 1308.12 (alphaprodine). (drugfuture.com)
- There are two isomers of the trans form of prodine, alphaprodine and betaprodine. (wikipedia.org)
- Both exhibit optical isomerism and alphaprodine and betaprodine are racemates. (wikipedia.org)
- Betaprodine is some five times more potent than alphaprodine, but is metabolized more rapidly, and only alphaprodine was developed for medicinal use. (wikipedia.org)
- Betaprodine produces more euphoria and side effects than alphaprodine at all dose levels, and it was found that 5 to 10 mg of betaprodine is equivalent to 25 to 40 mg of alphaprodine. (wikipedia.org)
Piritramide2
- other somewhat more distant relatives include alphaprodine and piritramide. (metakraft.de)
- Also, the drug is a distant relative of alphaprodine and piritramide. (rehabnear.me)
Pethidine1
- Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines (piminodine, anileridine and others), the prodines (alphaprodine, MPPP, etc. ), bemidones (ketobemidone, etc.) and others more distant, including diphenoxylate and analogues. (psychonautwiki.org)
Distant1
- Also, the drug is a distant relative of alphaprodine and piritramide. (rehabnear.me)