Papillomavirus Infections: Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.Papillomaviridae: A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.Human papillomavirus 16: A type of ALPHAPAPILLOMAVIRUS especially associated with malignant tumors of the CERVIX and the RESPIRATORY MUCOSA.Human papillomavirus 18: A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.Uterine Cervical Neoplasms: Tumors or cancer of the UTERINE CERVIX.DNA Probes, HPV: DNA probes specific for the identification of human papilloma virus.Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Oncogene Proteins, Viral: Products of viral oncogenes, most commonly retroviral oncogenes. They usually have transforming and often protein kinase activities.Papillomavirus E7 Proteins: ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.Tumor Virus Infections: Infections produced by oncogenic viruses. The infections caused by DNA viruses are less numerous but more diverse than those caused by the RNA oncogenic viruses.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksClassification: The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.Red Cross: International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).Paeonia: A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Psychiatry: The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.Library Services: Services offered to the library user. They include reference and circulation.ArchivesPolymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Apolipoproteins D: A glycoprotein component of HIGH-DENSITY LIPOPROTEINS that transports small hydrophobic ligands including CHOLESTEROL and STEROLS. It occurs in the macromolecular complex with LECITHIN CHOLESTEROL ACYLTRANSFERASE. Apo D is expressed in and secreted from a variety of tissues such as liver, placenta, brain tissue and others.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Skin Neoplasms: Tumors or cancer of the SKIN.Pilomatrixoma: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401)Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Carcinoma, Basosquamous: A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)Chromogranin A: A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Receptors, Progesterone: Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.NIH 3T3 Cells: A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)United States Dept. of Health and Human Services: A cabinet department in the Executive Branch of the United States Government concerned with administering those agencies and offices having programs pertaining to health and human services.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Information Storage and Retrieval: Organized activities related to the storage, location, search, and retrieval of information.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Hysterectomy: Excision of the uterus.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Hyperglycemic Hyperosmolar Nonketotic Coma: A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Diagnostic Uses of Chemicals: Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Evidence-Based Nursing: A way of providing nursing care that is guided by the integration of the best available scientific knowledge with nursing expertise. This approach requires nurses to critically assess relevant scientific data or research evidence, and to implement high-quality interventions for their nursing practice.Nursing Research: Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Cell cycle dysregulation in oral cancer. (1/450)

The dysregulation of the molecular events governing cell cycle control is emerging as a central theme of oral carcinogenesis. Regulatory pathways responding to extracellular signaling or intracellular stress and DNA damage converge on the cell cycle apparatus. Abrogation of mitogenic and anti-mitogenic response regulatory proteins, such as the retinoblastoma tumor suppressor protein (pRB), cyclin D1, cyclin-dependent kinase (CDK) 6, and CDK inhibitors (p21(WAF1/CIP1), p27(KIP1), and p16(INK4a)), occur frequently in human oral cancers. Cellular responses to metabolic stress or genomic damage through p53 and related pathways that block cell cycle progression are also altered during oral carcinogenesis. In addition, new pathways and cell cycle regulatory proteins, such as p12(DOC-1), are being discovered. The multistep process of oral carcinogenesis likely involves functional alteration of cell cycle regulatory members combined with escape from cellular senescence and apoptotic signaling pathways. Detailing the molecular alterations and understanding the functional consequences of the dysregulation of the cell cycle apparatus in the malignant oral keratinocyte will uncover novel diagnostic and therapeutic approaches.  (+info)

Modulation of apoptosis by human papillomavirus (HPV) oncoproteins. (2/450)

The regulation of host-mediated apoptosis by the E6 and E7 oncoproteins has garnered attention because it is believed to be an important strategy employed by high-risk (HR)-human papillomaviruses (HPVs) to evade immune surveillance. Additionally, the revelation that E5 can protect cells from tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis suggests that it may also play a role in undermining host defense mechanisms. Cellular transformation is an unintended consequence of persistent infection by HR-HPVs, and it is therefore likely that the primary function of E5, E6 and E7 is to regulate cell survival throughout the normal viral life cycle in order to ensure viral replication and promote the spread of progeny. The purpose of this article is to review the literature on the regulation of host-mediated apoptosis by E5, E6 and E7 that describes the mechanisms employed by HR-HPVs to persist in the host and create the conditions necessary for cellular transformation.  (+info)

Vaccines for the prevention of human papillomavirus infections. (3/450)

Human papillomavirus (HPV) infection is the known cause of almost all cases of cervical cancer. An understanding of the HPV genome has allowed the development of two prophylactic vaccines capable of protecting against both persistent HPV infection and cervical intraepithelial neoplasia (CIN) with 100% efficacy in fully vaccinated women. The vaccines, manufactured by Merck (Gardasil, which was approved by the US FDA in June, 2006) and GlaxoSmithKline (Cervarix, which will be submitted for US FDA approval by the end of 2006), both target HPV types 16 and 18, which together account for 70% of cervical cancer. Merck vaccine also targets HPV 6 and 11, covering =90% of genital warts. These vaccines are highly immunogenic and have an excellent safety profile. HPV vaccines promise to offer an exciting contribution to healthcare and cancer prevention. However, many questions remain concerning who to vaccinate, the duration of protection, cost, public acceptance, and the potential for worldwide distribution.  (+info)

Prevalence of human papillomavirus (HPV) in oral cavity and oropharynx. (4/450)

The prevalence of human papillomavirus (HPV) in the oral cavity and oropharynx has not yet been as well studied as its infection of the vaginal tract. However, new study are emerge after the development of molecular biology techniques. The objective of this study is to show the prevalence of HPV in the oral cavity and the oropharynx. An ample bibliographic review was done showing a prevalence of HPV 6, 11 in a normal oral mucous membrane (latent infection). In oral benign lesions associated with HPV, a prevalence of HPV 6 and 11 was observed in squamous cell papilloma (SCP) and condylomas acuminatum, while HPV 2 and 57 were more prevalent in verruca vulgaris lesions. As for focal epithelial hyperplasia (FEH) and oral cancer, especially squamous cell carcinoma (SCC), the prevalence was of HPV 13 and 32, and HPV 16, respectively. The last findings are, nonetheless, controversial. The last findings are, nonetheless, controversial. Showed also discrepancy result the prevalence of human papillomavirus (HPV) in normal oral mucous (latent infection) and in oral cancer, however evidenced confirmatory result in oral benign lesions associated with virus.  (+info)

Epidemiology and natural history of human papillomavirus infections in the female genital tract. (5/450)

Human papillomavirus (HPV) is the most common newly diagnosed sexually transmitted infection in the United States. Although the majority of sexually active adults will be infected with HPV at least once in their lives, it is sexually active women less than 25 years of age who consistently have the highest rates of infection. Besides youth and gender, common risk factors for HPV infection and clinical sequelae of infection include high number of sexual partners and coinfection with Chlamydia trachomatis or herpes simplex virus. Most HPV infections are cleared by the immune system and do not result in clinical complications. Clinical sequelae in cases of low-risk HPV infection consist of genital warts, and clinical manifestations of high-risk HPV infection include abnormal Pap test results, low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and cervical cancer. LSIL, HSIL, and cervical cancer carry significant morbidity and/or mortality; genital warts and abnormal Pap test results are often significant sources of psychosocial distress. Currently, there are neither effective means of preventing HPV transmission nor cures for clinical manifestations: infection can only be prevented via complete sexual abstinence, while treatment for clinical sequelae such as genital warts and cytologic abnormalities consists of removing the problematic cells and watching for recurrence; this method consumes significant health care resources and is costly. New prophylactic HPV vaccines promise to dramatically reduce the incidence of HPV infection, genital warts, and cytologic abnormalities.  (+info)

Reducing the health burden of HPV infection through vaccination. (6/450)

Human papillomavirus (HPV), a sexually transmitted infection and the etiologic cause of genital warts and cervical cancer, is highly prevalent in sexually active men and women. Although cervical screening procedures have significantly reduced the disease burden associated with HPV infection, they are expensive and abnormal results cause significant emotional distress. Therefore, prevention may be an effective strategy for reducing the economic, psychosocial, and disease burden of HPV infection. Multivalent vaccines are now in clinical development. A bivalent vaccine that protects against HPV 16 and 18, and a quadrivalent vaccine which protects against HPV types 6, 11, 16, and 18, have been shown to significantly reduce the occurrence of incident and persistent HPV infections in phase 2 clinical trials; phase 3 trials are currently underway. HPV vaccines will be most effective when administered prior to initiation of sexual activity, and vaccination campaigns should aggressively target preadolescent and adolescent populations.  (+info)

E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. (7/450)

The functional role of UV irradiation, in combination with the E6 and E7 proteins of the cutaneous human papillomavirus (HPV) types in the malignant conversion of benign papillomatous lesions, has not been elucidated. Transgenic SKH-hr1 hairless mice expressing HPV-20 and HPV-27 E6 and E7 proteins in the suprabasal compartment were generated and exposed to chronic UV irradiation. Histological and immunohistochemical examination of skin samples revealed enhanced proliferation of the epidermal layers and papilloma formation in both transgenic strains in comparison to what was observed with nontransgenic mice. Squamous cell carcinoma developed in the HPV-20 E6/E7 transgenic line as well as in the HPV-27 E6/E7 transgenic line. Several weeks after cessation of UV-B exposure, enhanced proliferation, as measured by BrdU incorporation, was maintained only in HPV-20 transgenic skin. Keratin 6 expression was increased in the transgenic mice throughout all cell layers. Expression of the differentiation markers involucrin and loricrin was reduced and disturbed. p63alpha expression was differentially regulated with high levels of cytoplasmic expression in clusters of cells in the granular layer of the skin in the transgenic lines 20 weeks after cessation of UV-B exposure, in contrast to uninterrupted staining in the nontransgenic lines. p53 was expressed in clusters of cells in nontransgenic and HPV-27 transgenic mice, in contrast to an even distribution in a higher number of cells in HPV-20 transgenic animals.  (+info)

Human papilloma virus and p53 expression in bladder cancer in Egypt: relationship to schistosomiasis and clinicopathologic factors. (8/450)

The aim of the current study was to compare the role of p53 and human papillomavirus (HPV) in schistosomiasis-related and schistosomiasis-unrelated carcinoma of the urinary bladder. To achieve this aim, we investigated 114 bladder carcinomas for p53 oncoprotein expression by immunohistochemistry and for human papillomavirus by in situ hybridization technique. The results revealed that 64 tumors (56.1%) were schistosomiasis-associated. Sixty seven (58.8%) were transitional cell carcinomas and 32 (28%) were squamous cell carcinomas. The remaining 15 tumors (13.2%) included adenocarcinomas and sarcomatoid carcinomas. In both schistosomiasis-associated and non-associated carcinomas, p53 oncoprotein expression was significantly higher in poorly differentiated tumors. However, it was significantly higher in locally more invasive tumors in the schistosomal carcinomas only. HPV types 16/18 could be detected in 1 of the 114 bladder carcinomas (0.95%), which was schistosomiasis-related squamous cell carcinoma in situ. These results suggest that p53 immunohistochemistry can be a prognostic factor in both schistosomal and nonschistosomal bladder cancer. More importantly, HPV does not seem to play a role in the pathogenesis of either type of bladder cancer in our country.  (+info)

*Alphapapillomavirus

9 Alphapapillomavirus 10 Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 Viruses in ... Group: dsDNA Order: Unassigned Family: Papillomaviridae Genus: Alphapapillomavirus Alphapapillomavirus 1 Alphapapillomavirus 2 ... Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are ... 3 Alphapapillomavirus 4 Alphapapillomavirus 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 ...

*Papillomaviridae

Group: dsDNA Order: Unassigned Family: Papillomaviridae Genus: Alphapapillomavirus Alphapapillomavirus 1 Alphapapillomavirus 2 ... They have been divided into 5 genera: Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, Mupapillomavirus and ... 9 Alphapapillomavirus 10 Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 Genus: ... 3 Alphapapillomavirus 4 Alphapapillomavirus 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 ...

*Taxonomic list of viruses

4 Alphapapillomavirus 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 Alphapapillomavirus 9 Genus: ... 1 Alphapapillomavirus 10 Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 ... Alphapapillomavirus 2 Alphapapillomavirus 3 Alphapapillomavirus ...

*List of genera of viruses

Alphaguttavirus Alphalipothrixvirus Alphamesonivirus Alphanecrovirus Alphanodavirus Alphanudivirus Alphapapillomavirus ...

*List of virus species

Alphamesonivirus 5 Alphapapillomavirus 1 Alphapapillomavirus 2 Alphapapillomavirus 3 Alphapapillomavirus 4 Alphapapillomavirus ... 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 Alphapapillomavirus 9 Alphapapillomavirus 10 ... Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 Alphaproteobacteria virus phiJl001 ...
The focus of this research was to compare the binding profiles of human papillomavirus (HPV) 11, 16, 18 and 45 virus-like particles (VLPs) to HaCaT cells and to the extracellular matrix (ECM) secreted by these cells. All four HPV types tested bind to a component(s) of the ECM. HPV11 VLP binding is blocked when the ECM is pretreated with an anti-laminin 5 (LN5) polyclonal antibody. A series of treatments utilizing heparins and heparinase revealed that HPV18 VLPs are dependent on heparan sulfates (HS) for binding to cells and ECM. HPV16 and HPV45 VLPs are dependent on HS for binding to HaCaT cells and dependent on both HS and LN5 for binding to ECM. These studies emphasize the need to study the binding characteristics of different HPV types before applying universal binding principles to all papillomaviruses.
Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS ...
Le gène L1 encode pour la protéine majeure de la capside des papillomavirus humains (VPH). Linformation relative au polymorphisme de L1 pour les types autres que VPH- 16 est jusquici limitée. Cet ouvrage explore le polymorphisme de L1 en comparant les séquences des types phylogénétiquement apparentés VPH-31, -33, -35 à VPH-16. Des spécimens génitaux recueillis de 732 femmes VIH-séropositives et 323 VIHséronégatives ont été criblés à le recherche dADN de VPH par PCR consensus au niveau du gène L1. Les échantillons positifs pour VPH-16 (n=74), -31 (n=74), -33 (n=37) et -35 (n=58) étaient analysés par PCR-séquençage pour la totalité du gène L1. Le nombre de nucléotides substitués pour L1 variait de 19 pour VPH-33 à 52 pour VPH-31. Le rapport du nombre de variantes sur le nombre disolats testés était plus élevé pour VPH-31 (56.4%, p=0.05) et VPH-35 (60.3%, p=0.04) comparativement à VPH-16 (40.5%), alors que ce ratio était inférieur pour VPH-33 mais sans ...
We guarantee that if we place an item on sale less than 7 days after you bought it at full price, just let us know and we will happily refund you the difference. This offer only applies to purchases made within the last 7 days, and only if we have the same size and color of that item in stock at the time. This offer does not apply to special sales, use of gift certificates, rebates or gift with purchase promotions.. Simply contact us within 7 days of your purchase by email with our Email Form or by phone at 1-800-369-3949.. ...
Best DNA Tests reviews DNA testing companies and provides DNA testing articles to help you understand results. Read guides before you buy
The difference is, of course, that expensive Gardasil will be used in the US, where it is least needed. Although at least 80 percent of women here will be infected by the HPV virus, 95 percent of those infections will be shrugged off by healthy immune systems, leaving in their wake a natural immunity to further infection. Of the small percentage of cases that become persistent, many could be avoided by eating a healthy diet with fruits and vegetables, quitting smoking, getting enough sleep, limiting sexual partners, etc. And most (granted, not all) persistent HPV infections that do turn to cancer can be caught early by regular screening ...
The vaccine is effective against genital warts, precancerous and cancerous growths on the cervix and genitals as well as persistent HPV infections.
We provide Genetic and Hormone Testing for Disease Predisposition which also known as DNA genetic screening test, donor screening test and more.
Dyed hair at home can seem intimidating, but it is actually quite once you know what to do. Dyed hair at home can also save you lots of time and money. Dyed
Quadrivalent human papillomavirus vaccine and autoimmune adverse events: a case-control assessment of the vaccine adverse events.
This study compared the immunogenicity of human papillomavirus vaccine recombinant quadrivalent [Gardasil] in healthy adolescents versus HIV-infected
To develop the 1993 Sexually Transmitted Diseases Treatment Guidelines, experts from the Centers for Disease Control and Prevention reviewed the literature on sexually transmitted disease treatment, assembled tables of evidence, and listed key questions on therapeutic outcome: microbiologic cure, alleviation of symptoms, and prevention of sequelae and transmission. At a meeting with external experts, evidence was systematically assessed and guidelines developed. Quality of evidence for microbiologic cure was generally good for gonorrhea and chlamydia, poor for syphilis, and fair for most other diseases. Evidence on preventing sequelae and transmission was limited. The Guidelines include new recommendations for single-dose oral therapy of gonorrhea (cefixime, ciprofloxacin, and ofloxacin), chlamydia (azithromycin), and chancroid (azithromycin); outpatient therapy of pelvic inflammatory disease (ofloxacin and either clindamycin or metronidazole); and patient-applied therapy of genital warts ...
Gardasil deaths Gardasil. See: Gardasil deaths Ceravix deaths. GARDASIL AWARENESS NZ (GANZ). G / S New Zealand GARDASIL KILLED MY DAUGHTER - RHONDA RENATA [2010 Jan. Gardasil deaths NZ] Open Letter to Dr Stewart Jessamine from Hilary Butler The fact that at least THREE teenage girls died in their sleep between 1 September and 30 November 2009. These are only the ones we know about. One of those, Jasmine Renata, is confirmed as receiving the full Gardasil series before she died. Dr Shaw suggested that at autopsy, destruction of motor neurons should be looked for in brain samples, and the Morin stain for Aluminium should be used to ascertain it s presence in the brain ...
Role of the funding source Sponsor staff and clinical-site investigators designed the study. Sponsor staff were responsible for field monitoring, data entry, data review (including integrity and consistency checks), testing of clinical samples for HPV DNA and HPV immune responses, and analysis of data. Conflict of interest E Barr, M T Esser, K U Jansen, F J Taddeo, A J Saah, J Yu, L Lupinacci, R Railkar, H L Sings, and G M Tamms are employees of Merck Research Laboratories, a division of Merck & Co, and potentially own stock and hold stock options in the company, or both. Merck is developing the quadrivalent HPV vaccine and funded this clinical trial. K A Ault, D R Brown, D M Harper, R J Kurman, F E Skjeldestad, and L L Villa have received honoraria from Merck Research Laboratories given for consultation work or membership in the Phase III HPV Vaccine Steering and Registries Oversight Committees, or both, during the past 2 years. A Ferenczy, R J Kurman, B M Ronnett, and M H Stoler are members of ...
Gardasil was approved not too long ago by the FDA in June 2006. Since then there have been around 10,000 reports of side effects experienced, notably 21 deaths associated with its use. In addition to unknown side effects, Gardasil is one of the most expensive vaccines, costing $486 for the three shot series ...
| div|One hundred and twenty-two (72.6%) patients were infected with HPV, 75 (61%) had multiple HPV infection, and 94 (77%) had high-risk HPV infection.
Becca wanted to tell her story first hand about Gardasil. She has severe stomach pains now listed as side effects of the Gardasil shots.
The new Gardasil prevents cancer by safely and effectively vaccinating against several types of HPV that cause 90% of HPV related cancers.
AncestryDNA™ is the newest DNA test which helps you find genetic relatives and expand your genealogy research. Order your DNA test kit today.
The Gardasil vaccine has changed Skylees life in so many ways and we do not know how many more symptoms will show up and change her life even more than it has
My son was offered gardasil today and I refused it until I can gather more info. What are your thoughts on the vaccine? It seems pretty new. My doc recommends it. My nurse friends say yes. Scary Google says no. My sister said no. Just curious Dts thoughts.
A new DNA test cuts the time it takes to find horsemeat in food from two days to less than four hours. The process was developed by QIAGEN, the worlds leading provider of molecular sample and assay technologies.
A parent who wished to make an informed decision on vaccinating their child and the difficulty they incurred at not being told the complete story.
A parent who wished to make an informed decision on vaccinating their child and the difficulty they incurred at not being told the complete story.
Discover your dogs unique story with Embark. By testing your dogs DNA, we accurately identify breed, traits, and risk for over 160 genetic health conditions.
Discover your dogs unique story with Embark. By testing your dogs DNA, we accurately identify breed, traits, and risk for over 160 genetic health conditions.
One clinical study evaluated efficacy of monovalent HPV 16 vaccine, and three studies evaluated efficacy of quadrivalent HPV vaccine: a phase II study of a monovalent HPV 16 vaccine (protocol 005) (106,107), a phase II study of quadrivalent HPV vaccine (protocol 007) (108--110), both among females aged 16--23 years, and two phase III studies of quadrivalent HPV vaccine (protocols 013 and 015) among females aged 16--23 and 16--26 years, respectively. All were randomized, double-blind, placebo-controlled studies. The studies used prespecified endpoints to evaluate the impact of the quadrivalent vaccine in preventing HPV-related infection and disease. Phase II studies were primarily proof-of-concept studies that evaluated the efficacy of vaccine using a persistent infection endpoint. Phase III studies evaluated the efficacy of vaccine on clinical lesions. Predefined combinations of phase II and III studies were used to improve the precision of the efficacy findings. Various endpoints were assessed ...
article{0e6c131c-f2e0-4699-af87-cfeb1569551b, abstract = {Background A randomised double-blind placebo-controlled phase II study was done to assess the efficacy of a prophylactic quadrivalent vaccine targeting the human papillomavirus (HPV) types associated with 70% of cervical cancers (types 16 and 18) and with 90% of genital warts (types 6 and 11). Methods 277 young women (mean age 20.2 years [SD 1.7]) were randomly assigned to quadrivalent HPV (20 μ g type 6, 40 μ g type 11, 40 μ g type 16, and 20 μ g type 18) L1 virus-like-particle (VLP) vaccine and 275 (mean age 20.0 years [1.7]) to one of two placebo preparations at day 1, month 2, and month 6. For 36 months, participants underwent regular gynaecological examinations, cervicovaginal sampling for HPV DNA, testing for serum antibodies to HPV, and Pap testing. The primary endpoint was the combined incidence of infection with HPV 6, 11, 16, or 18, or cervical or external genital disease (ie, persistent HPV infection, HPV detection at the ...
Results The 4vHPV genotypes decreased from 20% in 2004/05 to 3% in 2014/15 (p trend , 0.001) among Australian-born men; and a greater decline was observed in Australian-born men aged ≤21 (from 31% to 0%; p trend, 0.001) in the last 11 years. No trends were observed in any HPV genotypes or in HPV 31/33/45/52/58. There was a decline in HPV 16/18 (p = 0.004) but not in HPV 6/11 (p = 0.172) in the post-vaccination period among men who recently arrived in Australia from countries with a bivalent vaccine programme. No change in 4vHPV in men from countries without any HPV vaccine programme. ...
The Swedish study also suggested that the opportunity to do a HPV test at home could increase the number of women screened for cervical cancer who otherwise do not respond to screening invitations.. The research1, published today in the British Journal of Cancer2, looked at around 2800 women who took a self-sample HPV test at home.. Those with a positive result were invited for a repeat HPV test at a clinic, between one and three months after the first test.. This was to see if there was a persistent HPV infection, which is more likely to lead to changes in the cells of the cervix.3. If the second test was also positive it was more likely that there were abnormal cell changes on the cervical lining which could become cancerous - treating these changes can prevent cervical cancer from developing.. While most women infected with HPV do not develop cervical cancer, the virus is a major cause of the disease.. The researchers suggest testing for HPV twice means that fewer women would be called for ...
Persistent infection by HPV causes cancers, and can be prevented - About 79 million American women are infected with HPV with about 14 million becoming newly infected each year. In 2010, there were 11,818 American women diagnosed with cervical cancer, and 3939 cervical cancer deaths. Persistent infection by HPV is a necessary factor in the pathologic process which may lead to cervical cancer development. Cervical cancer is a major fatal malignancy among women, causing about 275,000 deaths annually worldwide, mostly in developing countries. Cervical cancer is also a highly preventable disease if detected at its precancerous stages and treated by ablative procedures. The current HPV tests do not screen for persistent HPV infection - HPV testing has a clinical role in identifying individuals with an increased risk of an HPV-associated cervical precancer or cancer. Four tests are currently approved by the Food and Drug Administration (FDA) for detecting clinically significant levels of any of 13-14 ...
More than a quarter of U.S. women are infected with a sexually transmitted virus that sometimes can cause cervical cancer, health researchers say. The study, conducted by the U.S. Centers for Disease Control, provides the most comprehensive assessment of human papillomavirus prevalence among American women. According to the study, just 3.4 percent of women were infected with the two types of HPV that cause 70 percent of cervical cancers or two others that cause most cases of genital warts and other health problems. Perry has been rebuked by social conservatives, who say his promotion of the vaccine condones pre-marital sex, and legislators who say he exceeded his constitutional powers by issuing the executive order. The earlier studies indicated that widespread use of the vaccine would save money because initial investments in the cost of the vaccine would be more than recouped by a reduction in cancer treatment expenses and eventually might increase the recommended interval between Pap smears,
Although there is consensus that most instances of cervical neoplasia originate from HPV infection, little is known about the additional influence of infections with multiple HPV types on cervical carcinogenesis. The results of the few studies that have reported on this issue are not consistent. At least in part, the heterogeneity in findings may stem from the fact that most studies have been based on prevalence analysis via cross-sectional detection of type-specific HPV infections, which may underestimate the cumulative effects due to exposure to different HPV types over time. Longitudinal, repeated-measurement investigations such as ours have the advantage of permitting the assessment of lesion risk in the context of coinfections detected sequentially over time spans that are relevant to the natural history of cervical carcinogenesis. We conducted a number of complementary analyses to assess the quantitative risk effect of infections with multiple HPV types with and without data restrictions ...
Gardasil 9, the latest human papilloma virus vaccine, will be given to all Australian 12- and 13-year-old students beginning in 2018. The announcement that Gardasil 9 would replace the quadrivalent Gardasil was made by the Prime Minister....
Gardasil victim found to have HPV DNA in her blood 2 Years Post-Vaccination 13 different vaccine vials - 13 different lots of Gardasil from around the world tested: Results - 100% contamination with HPV Recombinant DNA. SANE Vax Inc. contracted...
Gardasil victim found to have HPV DNA in her blood 2 Years Post-Vaccination 13 different vaccine vials - 13 different lots of Gardasil from around the world tested: Results - 100% contamination with HPV Recombinant DNA. SANE Vax Inc. contracted...
We decided to present estimates of time to clearance for incident infections only, rather than pooling both prevalent and incident cases. Calculating the average duration times for both prevalent and incident infections could result in an overestimation of duration of an infection because prevalent cases could overrepresent persistent infections at any point in time. We considered two definitions for HPV clearance when HPV types were classified into HR or LR groups. There were many instances when a participant had an infection with more than one HR or LR HPV type at the same visit or at a later visit. Therefore, the first definition was based on mutually exclusive HR or LR groups, and only the most persistent HPV type was included in the analysis. If a woman had an equally persistent HR and LR HPV infection, then she was only included in the HR group, and a woman had to have cleared the longest persisting type before her HPV infection was considered cleared. This approach had the advantage of ...
Far too many people are failing to question whether vaccination actually works. In the case of Gardasil, despite the horrifying stories being recorded in VAERS (the Vaccine reaction database), people are still subjecting their daughters to this nightmare. The fact is: that there isnt real evidence that ANY vaccines work. In the case of Gardasil, one of the scientists who worked on it admitted that the vaccine doesnt actually go after the strain of HPV often found coexisting with cervical cancer. EXCUSE ME? We are vaccinating girls with something that doesnt actually attack the strain of HPV that theyre supposed to be protected from? THEN WHY IS IT BEING PUSHED ...
The final efficacy analysis of a trial of 9-valent human papillomavirus (HPV) vaccine has shown a high preventive effect against disease due to the additional HPV pathogenic strains covered compared with the quadrivalent vaccine at up to 6 years. These findings were reported by Huh et al in The.... ...
There seems to be no good reason whatever to vaccinate children with Gardasil or any other vaccine for that matter. But the mega-marketing campaigns of this...
Robert A. Burger, MD, FACOG, FACS and Warner K. Huh, MD discuss the practice paradigm shift related to the approval of the HPV vaccine and HPV DNA test.
Most of the reported side effects of Gardasil are mild and do not pose a serious health threat with the most common complaint being injection site pain or irritation.
HPV is structurally very closely related to the lower animal papillomaviruses (Chapter 4). Un- like HCV (above), the viral genome is relatively stable, with only 1% of genomic variability originating ...
281) 599-5700. Cervical cancer - in most cases - is preventable. We know what will cause it, and we have the technology to fight the disease. While some diseases have easily detectable symptoms, more often than not, cervical cancer can go undetected without any warning signs until it is in its later stages. Thats why its imperative for women to become more educated about the disease and take preventative measures. CHRISTUS St. Catherine Hospital and the Center for Disease Control (CDC) recommend the following preventive screening tests:. ...
A siblings DNA test is an accurate and reliable way of determining whether siblings are full siblings, half siblings or unrelated.
Human papillomavirus prevalence, viral load and pre-cancerous lesions of the cervix in women initiating highly active antiretroviral therapy in South Africa: a cross-sectional study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Press Release issued Dec 10, 2012: Human Papillomavirus Infections - Pipeline Review, H2 2012, provides an overview of the indications therapeutic pipeline. This report provides information on the therapeutic development for Human Papillomavirus Infections, complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Human Papillomavirus Infections.
While the majority of Human papillomavirus (HPV) infections are transient and cleared within a couple of years following exposure, 10-20% of infections persist latently, leading to disease progression and, ultimately, various forms of invasive cancer. Despite the clinical efficiency of recently developed multivalent prophylactic HPV vaccines, these preventive measures are not effective against pre-existing infection. Additionally, considering that the burden associated with HPV is greatest in regions with limited access to preventative vaccination, the development of effective therapies targeting persistent infection remains imperative. This review discusses not only the mechanisms underlying persistent HPV infection, but also the promise of immunomodulatory therapeutic vaccines and small-molecular inhibitors, which aim to augment the host immune response against the viral infection as well as obstruct critical viral-host interactions.
This group includes 241 international subjects, who either: (1) received placebo during the base study and continued in the Extension to receive a dose of GARDASIL (20/40/40/20 mcg formulation of qHPV vaccine) at Month 60 (plus 2 and 3 at Months 62 and 66, respectively, (2) received 3 doses of GARDASIL during the Base study and continued into the Extension to receive a fourth dose of GARDASIL at Month 60 for the purposes of investigating whether a fourth dose of vaccine (administered ~4.5 years following completion of a 3-dose primary regimen) induces HPV 6, 11, 16, and 18 antibody responses that characterize immune therapy ...
This group includes 241 international subjects, who either: (1) received placebo during the base study and continued in the Extension to receive a dose of GARDASIL (20/40/40/20 mcg formulation of qHPV vaccine) at Month 60 (plus 2 and 3 at Months 62 and 66, respectively, (2) received 3 doses of GARDASIL during the Base study and continued into the Extension to receive a fourth dose of GARDASIL at Month 60 for the purposes of investigating whether a fourth dose of vaccine (administered ~4.5 years following completion of a 3-dose primary regimen) induces HPV 6, 11, 16, and 18 antibody responses that characterize immune therapy ...
Online Doctor Chat - Human papillomavirus infection, Ask a Doctor about diagnosis, treatment and medication for Sexually transmitted disease, Online doctor patient chat conversation by Dr. Yogesh D
Giuliano AR ; Palefsky JM ; Goldstone S ; Moreira ED ; Vardas E ; Aranda C ; Jessen H ; Ferris DG ; Coutlee F ; Marshall BG ; Vuocolo S ; Haupt RM ; Guris D ; et al (2012) ...
gardasil vaccine - MedHelps gardasil vaccine Center for Information, Symptoms, Resources, Treatments and Tools for gardasil vaccine. Find gardasil vaccine information, treatments for gardasil vaccine and gardasil vaccine symptoms.
The most common sexually transmitted infection in the United States, human papillomavirus (HPV) is a strange kind of pathogen. "While your risk of contracting it is high, its likely you wont even know youre infected," says Dr. Marcus Wagner, a radiation oncologist with Tennessee Oncology at CHI Memorial Hospital. And while it often clears up on its own within two to three years, it doesnt always. According to the Center for Disease Control, more than 150 virus strains can be categorized as HPV. Around 40 of those strains can infect the genital area and are transmitted through direct sexual activity or intimate skin-to-skin contact. "They are so common that most sexually-active men and women will be infected at some point in their lives," says Dr. Lara Rabaa, a pediatrician with Tennova Primary Care. Statistics show likely 1 in 5 Americans has an active HPV infection right now. The scary part? "Persistent HPV infection can lead to not only anogenital warts, but also serious cancers in both ...
Learn about the potential side effects of Gardasil (human papillomavirus vaccine). Includes common and rare side effects information for consumers and healthcare professionals.
hi, I got the Gardasil shot in my hip and put on birth control ten months ago. Since then my life has been ***l. I have had pain in my groin and in the hip joint. I have a lymph node in my groin that has had lump in it since the Gardasil injection. I have been through so many tests by doctors its ridiculous.Yet i still dont have an answer to my problems. I have had hip pain, shoting nerve pain down my leg, i have had fatige and muscle weakness in my leg. The pain comes and goes and so do the fair ups. I used to have a healthy and active life. Now i cant even exercise for thirty minutes without being in pain for the next week. I have since gone off the birth control to determine which was causing my problems but it has had no effect. Can anyone help?My daughter has had numerous side affects to what I beleive are from the Gardasil vaccine. Her life is not the same. From my research and from Doctors with no anwers I beleive she has aluminum posoining from the shot. Pulmonary problems to ...
A: Because the vaccines protection against HPV 18 can wear off in as little as three years, a girl vaccinated at 12 could lose her protection against cervical cancer just when she is most likely to become sexually active-at 15 or 16.. Health officials have recommended that girls get vaccinated at age 12 based on Mercks conclusion that Gardasil is not effective against current (active) HPV infections, and therefore is most effective for girls who are not yet sexually active. But the companys own research shows that the vaccine is as effective or more effective among girls and women with previous (not active) HPV infections as among young girls who have never been exposed to HPV through sex. This is good news because older girls and women with past exposure to HPV are clearly sexually active and therefore are more in need of the protection that Gardasil provides. New research from France also supports this: a French researcher recently presented results of a study on 17,000 women and found that ...
Free Online Library: AutoGenomics Receives a Key European Patent for HPV Detection. by BIOTECH Patent News; Biotechnology industry Business Papillomavirus infections
CO- realized viral investigations (HPV DNA detection and genotyping, viral load by Real-time PCR, viral status). Cervical explants were used for cell lines initialization. 68 patients (age 16-60 y o) divided in three category were included in the study group. In CIN1 lesions multiple HPV infections and high HPV levels were noted. By contrast, in CIN3 lesions only single HPV infections with high risk types (16, 18) were observed. In these patients viral loads decreased while the percent of mixed or integrated viral forms increased. ...
As August is Immunization Awareness Month in the US we wanted to discuss Gardasil 9, the new 9-valent HPV Vaccine that was released to the public!
My last post on Gardasil has garnered quite a bit of interest so I thought I would follow it up with a look at some of the other claims about this vaccine that are also geared towards warning women away from it. The focus of this entry is, as the title implies, the ingredients of…
When one looks at the independent literature, so, studies which are not sponsored by the vaccine manufactures . . with relation to Gardasil, there have been several reports documenting multiple sclerosis and encephalitis, which is brain...
NEW YORK (GenomeWeb News) - Hologic said after the close of the market on Thursday that the US Food and Drug Administration has approved the Aptima HPV 16 18/45 genotype assay for use on the Panther system.
DNA Center India provides AABB Accredited DNA test with affordable cost. We offer DNA Test in Cuttack Odisha at best cost, full accuracy and fast result.
HPV is painful to anyone who is told they have aquired the HPV virus..whether it be high or low-risk. When I was diagnosed my provider said thank God its only...
ACCORDING to the recommendation of the Council of Islamic Ideology, DNA tests are unacceptable evidence of rape cases. It sparks debate in the world
Is your mixed breed dog a mystery? With dog DNA tests, you can learn what breeds make him who he is and what genetic health conditions he could develop.
A new study suggests that girls and women may not need all three recommended doses of HPV vaccine to get the necessary protection to prevent cervical cancer.
When deciding which consumer genetics test to take to learn more about your ancestry or health, keep in mind what you hope to get out of the experience.
TY - JOUR. T1 - A population-based cross-sectional study of age-specific risk factors for high risk human papillomavirus prevalence in rural Nigeria. AU - Clarke, Megan A.. AU - Gage, Julia C.. AU - Ajenifuja, Kayode O.. AU - Wentzensen, Nicolas A.. AU - Adepiti, Akinfolarin C.. AU - Wacholder, Sholom. AU - Burk, Robert D.. AU - Schiffman, Mark. PY - 2011. Y1 - 2011. N2 - Background: Cervical cancer, caused by persistent infection with carcinogenic human papillomavirus (HR-HPV), is particularly prevalent in Sub-Saharan Africa and is associated with a high mortality rate. Some studies in West Africa, including our own, have found unusually high HR-HPV across all ages with a slight peak in older women. This increased prevalence at older ages may complicate screen-and-treat programs, which are implemented in regions where HPV prevalence declines with age and typically target women between 30-49 years. A better understanding of the determinants of high HR-HPV prevalence at older ages is needed. The ...
Among women positive for HPV-6, -11, -16, or -18 at enrollment, vaccine efficacy was 100% (95% CI, 79%-100%) for the prevention of CIN2, CIN3, and AIS-lesions that represent true precursors of squamous cell and adenocarcinoma of the cervix. The observed quadrivalent vaccine efficacy for the prevention of all CIN due to the remaining HPV types in this population was 91% (95% CI, 76%-98%) (table 5) after an average of 3 years of follow-up. All 4 cases of CIN in the vaccine group were CIN1 lesions (1 lesion related to each HPV vaccine type; all 4 subjects received all 3 doses of vaccine). One subject who was PCR positive for HPV-18 at day 1 was given a diagnosis of HPV-6-related CIN1 at month 3. Another subject who was PCR positive for HPV-18 at day 1 was given a diagnosis of HPV-16-related CIN1 at month 7. For these 2 subjects, the index infection occurred before completion of the 3-dose vaccination regimen. The remaining 2 subjects received diagnoses of CIN1 lesions at month 12. One subject was ...
As immunization programs for human papillomavirus (HPV) are implemented more widely around the world, interest is increasing in measuring their impact. One early measurable impact of HPV vaccine is on the prevalence of specific HPV types in a population. In low-resource settings, a potentially attractive strategy would be to monitor HPV prevalence using clinical cervical cancer screening test results to triage specimens for HPV typing. We assessed this approach in a nationally representative population of U.S. females aged 14-59 years. Using self-collected cervico-vaginal swab specimens from 4,150 women participating in the National Health and Nutrition Examination Survey during 2003-2006, we evaluated type-specific HPV prevalence detected by the Roche linear array (LA) research test on all specimens, compared with type-specific HPV prevalence detected by LA conducted only on specimens positive by the digene hybrid capture 2 (HC-2) clinical test. We calculated weighted prevalence estimates and ...
The systematic review by Rambout et al is a high-quality synthesis of the evidence to date on the effectiveness of prophylactic HPV vaccination in preventing persistent HPV infection and precancerous cervical changes in young women. Infection with HPV is common;1 however, current primary prevention strategies, such as condom use, can only reduce the risk of transmission.2 The vaccines included in this review provide highly effective protection against 2 high-risk HPV types (16 and 18), which account for 70% of all cervical cancers. 1 of the vaccines tested provides additional coverage against non-oncogenic HPV types 6 and 11, which have been associated with the development of external genital disease.. Questions remain about the long-term effectiveness of the vaccine in reducing cervical cancer incidence and mortality, effectiveness of the vaccine in real world populations, duration of effect, and the optimal age to immunise young women if the vaccine is publicly funded. Despite these gaps in ...
RATIONALE: Gathering information about human papillomavirus infection of the mouth in young men may help doctors learn more about risk factors for oroph
HPV- Human Papillomavirus Infection - By: Brooke Covington by Brooke C | This newsletter was created with Smore, an online tool for creating beautiful newsletters for for educators, nonprofits, businesses and more
Rochester, NY (PRWEB) July 09, 2014 The currently accepted medical belief holds that high risk HPV strains do not cause genital warts. Therefore, if someone has genital warts, this individual is not at risk of developing cancer. However, Dr. Park and colleagues found that 20.5% of all warts tested contained both high-risk and low-risk HPV types. (1) As a result, Dr. Park concluded that genital warts with high-risk HPV types may be considered a clinical marker of risk for developing a malignant disease. (1) In simple terms, this means that if someone has a genital wart, he or she should not feel safe. Unlike conventional beliefs, a genital wart is a sign that the infected individual is at risk of developing cancer. Dr. Park and colleagues are from the Smile Jungs Urology Clinic in Busan, Korea. Note that this study is so new, that major health websites such as Cancer.gov still says that sexually transmitted HPVs fall into two categories: low-risk HPVs, which do not cause cancer but can cause ...
The FDA approved the first DNA test for human papillomavirus (HPV) that can be used alone to help a health care professional assess the need for a woman to undergo additional diagnostic testing for cervical cancer. The cobas® HPV Test was first approved in 2011 for use either in conjunction with or as a follow-up to a Pap test; the test is now also approved as a co-test or as a primary cervical cancer screening test. The FDA was careful to stress that the expanded approval of the cobas HPV Test does not change current medical practice guidelines for cervical cancer screening, because those guidelines are set by other groups, not the FDA.. Human Papillomavirus. HPV is the most common sexually-transmitted infection (STI) in the United States, with more than 40 types of HPV that can affect the genital areas, mouth, and throat of both males and females. Most people with the HPV virus are not aware of the infection because there can be very few symptoms and the virus can lay dormant for years. There ...
TY - JOUR. T1 - Use of HPV testing for cervical screening in vaccinated women - insights from the SHEVa (Scottish HPV Prevalence in Vaccinated Women) study. AU - Bhatia, R. AU - Kavanagh, K. AU - Cubie, H. AU - Serrano, I. AU - Wennington, H. AU - Hopkins, M. AU - Pan, J. AU - Pollock, KG. AU - Palmer, TJ. AU - Cuschieri, K. PY - 2016/2/4. Y1 - 2016/2/4. N2 - The management of cervical disease is changing worldwide as a result of HPV vaccination and the increasing use of HPV testing for cervical screening. However, the impact of vaccination on the performance of HPV based screening strategies is unknown. The SHEVa (Scottish HPV Prevalence in Vaccinated women) projects are designed to gain insight into the impact of vaccination on the performance of clinically validated HPV assays. Samples collated from women attending for first cervical smear who had been vaccinated as part of a national "catch up" programme were tested with three clinically validated HPV assays (2 DNA and 1 RNA). Overall HR-HPV ...
In January 2017, the Dutch cervical cancer screening programme transitioned from cytomorphological to primary high-risk HPV (hrHPV) DNA screening, including the introduction of self-sampling, for women aged between 30 and 60 years. The Netherlands was the first country to switch to hrHPV screening at the national level. We investigated the health impact of this transition by comparing performance indicators from the new hrHPV-based programme with the previous cytology-based programme. We obtained data from the Dutch nationwide network and registry of histo- and cytopathology (PALGA) for 454,573 women eligible for screening in 2017 who participated in the hrHPV-based programme between 1 January 2017 and 30 June 2018 (maximum follow-up of almost 21 months) and for 483,146 women eligible for screening in 2015 who participated in the cytology-based programme between 1 January 2015 and 31 March 2016 (maximum follow-up of 40 months). We compared indicators of participation (participation rate), referral
Human papillomavirus (HPV) infection was more likely to develop into cervical pre-cancer in women living with human immunodeficiency virus, a study of Senegalese women has shown.Powered by WPeMatico While most HPV infections are cleared by the bodys immune system, persistent HPV infection can lead to the development of precancerous lesions and cervical cancer, shows research…
Definition : Molecular assay reagents intended to identify high cancer risk types of human papilloma virus (HPV), of the family Papovaviridae, by detecting the deoxyribonucleic acid (DNA) of the target viruses. High-risk HPV types usually infect the anogenital tract epithelium, but they can also be found in the oral mucosa, conjunctiva, and respiratory tract; the most common high-risk types include HPV types 16 and 18, but types 45 and 56 are usually included in this test. These HPV genotypes cause mucosal infections and are associated with malignancy.. Entry Terms : "Reagents, Molecular Assay, Infection, Virus, Human Papilloma Virus, High-Risk Type, DNA". UMDC code : 22306 ...
I have been diagnosed with oral hpv type 31 (high risk for cancer) i have genital hpv too (and cervix hurt with some blood), im a woman 23 years old. I took a lot of suplements, vitamins in past 10 mo...
Human Papillomaviruses (HPVs) cause both benign and malignant epithelial tumors in humans. They also cause latent infections of skin and mucus membranes of the...
Strict Standards: mktime(): It is not safe to rely on the systems timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected Europe/Berlin for CEST/2.0/DST instead in /homepages/24/d269161222/htdocs/2006/beta/wp-includes/functions.php on line 24 ...
Strict Standards: mktime(): It is not safe to rely on the systems timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected Europe/Berlin for CEST/2.0/DST instead in /homepages/24/d269161222/htdocs/2006/beta/wp-includes/functions.php on line 24 ...
U.S. health officials in recent months have received reports of pain and fainting among teenage girls who receive Mercks human papillomavirus vaccine Gardasil, the AP/International Herald Tribune reports (Stobbe, AP/International Herald Tribune, 1/3). Gardasil in clinical trials has been shown to be 100% effective in preventing infection with HPV strains 16 and 18, which together […]. ...
that "most infections (by HPV) are short-lived and *not associated with cervical cancer*", in recognition of the advances in medical science and technology since 1988. In other words, since 2003 the scientific staff of the FDA *no longer considers HPV infection to be a high-risk disease* when writing educational materials for the general public whereas the regulatory arm of the agency is still bound by the old classification scheme that had placed HPV test as a test to stratify risk for cervical cancer in regulating the industry.// / Dalej FDA stwierdziła ze, przez zaszczepianie szczepionka HPV podwyższa się ryzyko zachorowania na raka o 44,6 % !!! /"PCR-based HPV detection device with provision for accurate HPV genotyping is more urgently needed now because vaccination with Gardasil of the women who are already sero-positive and PCR-positive for vaccine-relevant genotypes of HPV has ...
HPV infection can cause oral, cervical, anal, and other cancers. High-risk HPV 16 and HPV 18 cause most HPV-related cancers. Information and video answer questions: What is HPV? How is HPV transmitted? Does HPV infection cause symptoms? How does HPV cause cancer? Who should get the HPV vaccine?
Human papillomavirus infection has clearly been recognized as the cause of cervical cancer. Indeed, the infection of the cervix by certain oncogenic typ
Actual Gardasil side effects submitted by users. Gardasil is used to prevent genital warts and cervical/vaginal cancers caused by human papillomavi...
We have developed a new human papillomavirus (HPV) assay using the uniplex E6/E7 polymerase chain reaction (PCR) method, which is able to detect E6 and E7 genes in 39 HPV types. We validated the assay for sensitivity and specificity using cloned HPV DNA and clinical samples. A comparative study using Genosearch-31 (GS-31) to determine HPV genotypes in clinical samples was also performed. E6 or E7 genes, measured by uniplex E6/E7 PCR, were detectable in 15 low-risk (HPV-6, -11, -40, -42, -44, -54, -55, -61, -62, -71, -74, -81, -84, -89, -90), 11 intermediate-risk (HPV-26, -30, -34, -53, -66, -67, -69, -70, -73, -82, -85), and 13 high-risk (HR) HPV types ...
There isn t a single person who watches television that hasn t seen the ads One Less is the campaign theme created by drug maker Merck to promote Gardasil Approved by the FDA in June 2006 Gardasil is being aggressively marketed to parents
Georgia Gardasil side effect litigation attorneys discuss the governments failure to take steps to protect the publics safety concerning serious Gardasil side effects.
Reimers, Laura L; Mehta, Supriya D; Massad, L Stewart et al. (2016) The Cervicovaginal Microbiota and Its Associations With Human Papillomavirus Detection in HIV-Infected and HIV-Uninfected Women. J Infect Dis 214:1361-1369 ...
HPV Infection Genital Human Papilloma Virus (HPV) infection is the commonest Viral STI in the UK and the majority of sexually active individuals will have
The new , more powerful, version of the Gardasil cancer prevention vaccine, approved by the US FDA, protects teens and young adults from 9 subtypes of HPV
Merck & Co., Inc. Receives Approval to Market GARDASIL(R), ZOLINZA(R) and CUBICIN(R) in Japan - read this article along with other careers information, tips and advice on BioSpace
RESULTS:. The 42 selected articles enrolled 4066 patients. It was observed that oral or oropharyngeal human papillomavirus infections were identified in 738 patients (18.2%; IC 95 17.6-18.8), varying between 0.0% and 91.9%. The prevalences of oral or oropharyngeal human papillomavirus infections were respectively 6.2%, 44.6%, 44.4%, 27.4%, 38.5% and 11.9% for healthy people, those with benign oral lesions, pre-malignant lesions, oral or oropharyngeal squamous cell carcinoma, risk groups (patients with genital human papillomavirus lesions or infected partners) and immunocompromised patients. The risk of human papillomavirus infection was estimated for each subgroup and it was evident that, when compared to the healthy population, the risk of human papillomavirus infection was approximately 1.5-9.0 times higher, especially in patients with an immunodeficiency, oral lesions and squamous cell carcinoma. The rates of the most well-known oncogenic types (human papillomavirus 16 and/or 18) also show ...
Telomere maintenance is crucial in carcinogenesis and tumor progression. The results of a previous study from the authors indicated that infection with high-risk human papillomavirus (HR-HPV) types 16, 18, and 58 was a risk factor for esophageal squamous cell carcinoma (ESCC) in the Shantou region of China. In the current study, the authors explored the association between HR-HPV infection, telomere length (TL), and DNA methylation and their significance in the prognosis of patients with ESCC....
This study of Australian women presenting for routine Pap testing prior to the introduction of the National HPV Vaccination Program found HPV16 to be the most prevalent HPV genotype in Indigenous and non-Indigenous Australian women equally, and that the five most common high-risk types were the same in both groups. Detection of any HPV genotype was strongly associated with smoking, Pap-test abnormalities and younger age. Indigenous women living in remote areas did not have more HPV genotypes detected, or more or fewer vaccine-preventable types, but for non-Indigenous women, living in a major city was associated with a higher probability of having HPV detected, and for that type to be 16 or 18. Marked differences in the prevalence of HPV between Indigenous and non-Indigenous women were not found, although older Indigenous women (31 to 40 years old) had more non-HPV 16/18 types detected. The dominance of HPV16 is consistent with worldwide prevalence studies, but HPV51, the second most common ...

Alphapapillomavirus - WikipediaAlphapapillomavirus - Wikipedia

9 Alphapapillomavirus 10 Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 Viruses in ... Group: dsDNA Order: Unassigned Family: Papillomaviridae Genus: Alphapapillomavirus Alphapapillomavirus 1 Alphapapillomavirus 2 ... Alphapapillomavirus is a genus of viruses, in the family Papillomaviridae. Human and monkeys serve as natural hosts. There are ... 3 Alphapapillomavirus 4 Alphapapillomavirus 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 ...
more infohttps://en.wikipedia.org/wiki/Alphapapillomavirus

E6 E6 protein [Alphapapillomavirus 7] - Gene - NCBIE6 E6 protein [Alphapapillomavirus 7] - Gene - NCBI

Alphapapillomavirus 7 (old-name: Human papillomavirus - 18) Lineage. Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; ... E6 E6 protein [ Alphapapillomavirus 7 ] Gene ID: 1489088, updated on 16-Aug-2018 ...
more infohttps://www.ncbi.nlm.nih.gov/gene/1489088

Polymorphisme de la capside des papillomavirus appartenant à lespèce 
9 des alphapapillomavirusPolymorphisme de la capside des papillomavirus appartenant à l'espèce 9 des alphapapillomavirus

Polymorphisme de la capside des papillomavirus appartenant à lespèce 9 des alphapapillomavirus. dc.contributor.advisor. ... Polymorphisme de la capside des papillomavirus appartenant à lespèce 9 des alphapapillomavirus. en. ...
more infohttps://papyrus.bib.umontreal.ca/xmlui/handle/1866/3959?locale-attribute=en&show=full

Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types | Microbiology...Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types | Microbiology...

Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types * Tatevik R. ... Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types ...
more infohttps://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.012732-0

Human papillomavirus infection - WikipediaHuman papillomavirus infection - Wikipedia

Alphapapillomavirus. Betapapillomavirus. Gammapapillomavirus. Mupapillomavirus Nupapillomavirus HPV infection is limited to the ...
more infohttps://en.wikipedia.org/wiki/Human_papillomavirus

人類乳突病毒 - 维基百科,自由的百科人類乳突病毒 - 维基百科,自由的百科

人類乳突病毒(Human Papillomavirus,HPV)是一种DNA病毒,属于乳头瘤病毒科乳头瘤病毒属。該類病毒感染人體的表皮與黏膜組織,目前約有170种類型的HPV被判別出來,有些时候HPV入侵人體後會引起疣甚
more infohttps://zh.wikipedia.org/wiki/HPV

E7 - Protein E7 - Human papillomavirus type 16 - E7 gene & proteinE7 - Protein E7 - Human papillomavirus type 16 - E7 gene & protein

Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Firstpapillomavirinae › AlphapapillomavirusAlphapapillomavirus 9 ...
more infohttps://www.uniprot.org/uniprot/P03129

E2 - Regulatory protein E2 - Human papillomavirus type 18 - E2 gene & proteinE2 - Regulatory protein E2 - Human papillomavirus type 18 - E2 gene & protein

Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Firstpapillomavirinae › AlphapapillomavirusAlphapapillomavirus 7 ...
more infohttps://www.uniprot.org/uniprot/Q80B71

Rate of detection of high-risk HPV with two assays in women ≥ 30 years of age.Rate of detection of high-risk HPV with two assays in women ≥ 30 years of age.

Alphapapillomavirus / isolation & purification*. Cervical Intraepithelial Neoplasia / diagnosis, pathology, virology. ...
more infohttp://www.biomedsearch.com/nih/Rate-detection-high-risk-HPV/21724457.html

Papillomaviridae - WikipediaPapillomaviridae - Wikipedia

Group: dsDNA Order: Unassigned Family: Papillomaviridae Genus: Alphapapillomavirus Alphapapillomavirus 1 Alphapapillomavirus 2 ... They have been divided into 5 genera: Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, Mupapillomavirus and ... 9 Alphapapillomavirus 10 Alphapapillomavirus 11 Alphapapillomavirus 12 Alphapapillomavirus 13 Alphapapillomavirus 14 Genus: ... 3 Alphapapillomavirus 4 Alphapapillomavirus 5 Alphapapillomavirus 6 Alphapapillomavirus 7 Alphapapillomavirus 8 ...
more infohttps://en.wikipedia.org/wiki/Papillomaviridae

Virus-Taxonomie - WikipediaVirus-Taxonomie - Wikipedia

Genus Alphapapillomavirus (mit Species Alphapapillomavirus 1 bis 14). *Genus Betapapillomavirus (mit Species Betapapillomavirus ...
more infohttps://de.wikipedia.org/wiki/Virus-Taxonomie

Revision #5 - dsDNA Viruses - dsDNA Viruses (2011) - International Committee on Taxonomy of Viruses (ICTV)Revision #5 - dsDNA Viruses - dsDNA Viruses (2011) - International Committee on Taxonomy of Viruses (ICTV)

Genus Alphapapillomavirus. Type species Human papillomavirus 32. Distinguishing features. Members of this genus preferentially ... List of other related viruses which may be members of the genus Alphapapillomavirus but have not been approved as species. None ...
more infohttps://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae/revision/5

Phylogenetic relationship between the major capsid prot | Open-iPhylogenetic relationship between the major capsid prot | Open-i

Alphapapillomavirus/genetics*/immunology. *Capsid Proteins/immunology*. *Cross Protection*. *Oncogene Proteins, Viral/ ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4228199_gr3&req=4

Reactome | Advanced SearchReactome | Advanced Search

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
more infohttps://www.reactome.org/content/advanced

Medical Xpress - human papillomavirusMedical Xpress - human papillomavirus

Alphapapillomavirus Betapapillomavirus Gammapapillomavirus Mupapillomavirus Nupapillomavirus. A human papillomavirus (HPV) is a ...
more infohttps://medicalxpress.com/tags/human+papillomavirus/sort/rank/1d/

Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug InformationDrug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information

A type of ALPHAPAPILLOMAVIRUS causing recurrent respiratory PAPILLOMATOSIS; GENITAL WARTS; and other neoplasms. ...
more infohttps://druginfo.nlm.nih.gov/drugportal/sid/h033110000

Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)

A vaccine containing L1 capsid proteins from four types of HPV (ALPHAPAPILLOMAVIRUS), types 6, 11, 16 and 18 that is used to ... A type of ALPHAPAPILLOMAVIRUS usually associated with GENITAL WARTS; and LARYNGEAL NEOPLASMS. ... They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS. ...
more infohttps://www.bioportfolio.com/resources/trial/63002/Human-Papillomavirus-HPV-Vaccination-in-Barretos-Pio-XII-Foundation-Barretos-Cancer-Hospital.html

Human papillomavirus genome variants and head and neck cancers: a perspective | Springer for Research & DevelopmentHuman papillomavirus genome variants and head and neck cancers: a perspective | Springer for Research & Development

Alphapapillomavirus 7, Alphapapillomavirus 8), and differences of 10-30% define "types" (e.g., human papillomavirus 16 ... All twelve HR-HPV belong to the Alphapapillomavirus genus (species 5, 6, 7 or 9) but widely differ in prevalence (related to ... Alphapapillomavirus, Betapapillomavrius), differences of 30-40% define "species" (e.g., ... belonging to Alphapapillomavirus 9). Of note, the International Committee on Taxonomy of Viruses provides a taxonomic ...
more infohttps://rd.springer.com/article/10.1186/s13027-018-0185-6

Representation of simulated efficient frontiers of scen | Open-iRepresentation of simulated efficient frontiers of scen | Open-i

Alphapapillomavirus/isolation & purification*. *Computer Simulation*. *Models, Economic*. *Papillomavirus Infections/diagnosis ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3293782_deki874693.f1_default&req=4

ajcc stage ib cervical cancer 2005:2010[pubdate] *count=100 - BioMedLib™ search engineajcc stage ib cervical cancer 2005:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Alphapapillomavirus / isolation & purification. Carcinoma / virology. DNA, Viral / isolation & purification. Lymph ...
more infohttp://www.bmlsearch.com/?kwr=ajcc+stage+ib+cervical+cancer+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0

Code System ConceptCode System Concept

Genus Alphapapillomavirus (organism) {423398001 , SNOMED-CT } Parent/Child (Relationship Type) Human papillomavirus 32 ( ...
more infohttps://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=423398001