Tocopherols: A collective name for a group of closely related lipids that contain substitutions on the 2H-1-benzopyran-6-ol nucleus and a long hydrocarbon chain of isoprenoid units. They are antioxidants by virtue of the phenolic hydrogen. Tocopherols react with the most reactive form of oxygen and protect unsaturated fatty acids from oxidation.alpha-Tocopherol: A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.beta Carotene: A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)Vitamin E Deficiency: A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)F2-Isoprostanes: Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.gamma-Tocopherol: A natural tocopherol with less antioxidant activity than ALPHA-TOCOPHEROL. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in BETA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.Tocotrienols: Natural analogs of TOCOPHEROLS exhibiting antioxidant activity. These tocol derivatives and isomers contain a benzopyran ring and an unsaturated isoprenoid side chain.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Carotenoids: The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.beta-Tocopherol: A natural tocopherol with less antioxidant activity than alpha-tocopherol. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in GAMMA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.4-Hydroxyphenylpyruvate Dioxygenase: An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Intramolecular Transferases: Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups from one position within a molecule to another. EC 5.4.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.Abetalipoproteinemia: An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.Plastoquinone: Polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical bonds.Chromans: Benzopyrans saturated in the 2 and 3 positions.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Xanthophylls: Oxygenated forms of carotenoids. They are usually derived from alpha and beta carotene.alpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Plant Oils: Oils derived from plants or plant products.Sesamum: A plant genus of the family PEDALIACEAE that is the source of the edible seed and SESAME OIL.Homogentisic AcidIntegrin alpha3beta1: Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.Integrin alpha4: An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.Integrin alpha6: An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.Lutein: A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.Integrin alpha5beta1: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.Lettuce: Any of the various plants of the genus Lactuca, especially L. sativa, cultivated for its edible leaves. (From American Heritage Dictionary, 2d ed)Interleukin-1alpha: An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Integrin alpha2beta1: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Integrin alpha5: This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.Alkyl and Aryl Transferases: A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (excluding methyl groups). EC 2.5.Integrin alpha1beta1: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.Brassica rapa: A plant species cultivated for the seed used as animal feed and as a source of canola cooking oil.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Receptors, Adrenergic, alpha-2: A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.Kinetics: The rate dynamics in chemical or physical systems.Pyrogallol: A trihydroxybenzene or dihydroxy phenol that can be prepared by heating GALLIC ACID.Integrin alpha6beta4: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.Integrin alpha Chains: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Dimethylallyltranstransferase: An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopentenyl pyrophosphate and dimethylallylpyrophosphate to yield pyrophosphate and geranylpyrophosphate. The enzyme then catalyzes the condensation of the latter compound with another molecule of isopentenyl pyrophosphate to yield pyrophosphate and farnesylpyrophosphate. EC 2.5.1.1.Integrin alpha1: An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.PhytolRecombinant Proteins: Proteins prepared by recombinant DNA technology.Alpha Rhythm: Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Integrin alpha3: An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.PPAR alpha: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.Diet: Regular course of eating and drinking adopted by a person or animal.Hepatocyte Nuclear Factor 1-alpha: Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

All-rac-alpha-tocopherol acetate is a better vitamin E source than all-rac-alpha-tocopherol succinate for broilers. (1/780)

The difference in bioavailabilities of the acetate and succinate esters of all-rac-alpha-tocopherol was investigated in a feeding experiment with broilers. The experiment was initiated with 96 12-d-old male Cobb broilers and lasted for 4 wk. The two sources of vitamin E were fed to eight groups of broilers at four different dietary levels (50, 100, 150 and 200 mg/kg feed, including the naturally occurring alpha-tocopherol). A total collection of droppings for determination of apparent tocopherol absorption were performed at two separate time periods (d 28-34 and d 35-41). There were no differences among the eight experimental groups with respect to animal performance or feed intake. At all dietary levels, the apparent absorption coefficient for all-rac-alpha-tocopherol succinate was significantly lower than that of the acetate ester. The mean (+/- SD) apparent absorption coefficient for all-rac-alpha-tocopherol succinate was 58.0 +/- 5.4 compared with 70. 8 +/- 5.6 for all-rac-alpha-tocopherol acetate. Furthermore, the apparent absorption coefficients for both esters was significantly lower in the first collection period (d 28-34) than in the second collection period (d 35-41). This difference in the apparent absorption coefficient between the succinate and the acetate ester was accompanied by significant differences in alpha-tocopherol concentrations in plasma, breast muscle, liver and adipose tissue of the broilers, which were lower in those fed the succinate ester. Based on a comparison of plasma and tissue responses, the succinate ester was utilized only 69-76% as efficiently as the acetate ester. In vitro studies showed a significantly higher capacity of pancreatic carboxyl ester hydrolase to hydrolyze alpha-tocopherol acetate compared to alpha-tocopherol succinate. This difference in intestinal hydrolysis of the two vitamin E sources may explain the observed differences in biopotency.  (+info)

Effects of UV light and tumor promoters on endogenous vitamin E status in mouse skin. (2/780)

Recent reports indicate that both orally administered and topically applied alpha-tocopherol (vitamin E, TH) prevent UVB-induced skin carcinogenesis in mice. Because UVB exposure causes the formation of oxidants associated with tumor promotion, epidermal TH status may be an important determinant of susceptibility to photocarcinogenesis. To test this hypothesis, we studied the status of epidermal TH in C3H mice following exposure to single and repeated UVB exposures at doses typical of chronic photocarcinogenesis protocols. Exposure of mice to a single 13 kJ/m(2) dose over 60 min resulted in no acute depletion of epidermal TH and a modest increase in TH within 6-12 h. Daily exposure to 6.5 kJ/m(2) over 30 min resulted in a gradual increase in epidermal TH, which reached 5-fold after five daily exposures. The increase in epidermal TH was accompanied by an increase in the TH oxidation products alpha-tocopherolquinone (TQ) and alpha-tocopherolhydroquinone (THQ). We also studied the effect of the prooxidant chemical tumor promoter benzoyl peroxide and the prooxidant azo initiators azobis(amidinopropane HCl) and azobis(2, 4-dimethylvaleronitrile). Topical application of these prooxidant chemicals acutely oxidized epidermal TH to TQ and THQ. Topical treatments with the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increased epidermal TH levels without producing a significant accumulation of TH oxidation products. The results indicate that UVB and tumor promoting chemicals all exert qualitatively different effects on epidermal TH status and that UVB and TPA trigger an adaptive response involving epidermal TH accumulation.  (+info)

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. (3/780)

We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible for the extensive chromosomal damage and acceleration of hepatocarcinogenesis characteristic for TGFalpha/c-myc mice. In this study, we show that vitamin E (VE), a potent free radical scavenging antioxidant, is able to protect liver tissue against oxidative stress and suppress tumorigenic potential of c-myc oncogene. Dietary supplementation with VE, starting from weaning, decreased ROS generation coincident with a marked inhibition of hepatocyte proliferation while increasing the chromosomal as well as mtDNA stability in the liver. Similarly, dietary VE reduced liver dysplasia and increased viability of hepatocytes. At 6 mo of age, VE treatment decreased the incidence of adenomas by 65% and prevented malignant conversion. These results indicate that ROS generated by over-expression of c-myc and TGFalpha in the liver are the primary carcinogenic agents in this animal model. Furthermore, the data demonstrate that dietary supplementation of VE can effectively inhibit liver cancer development.  (+info)

Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. (4/780)

Two well-known antioxidative nutrients, vitamin E and selenium, were used in this study to investigate possible inhibitory action against the formation of esophageal adenocarcinoma (EAC) in rats. In this model, carcinogenesis is believed to be driven by oxidative stress. Male Sprague-Dawley rats (8 weeks old) were divided into four groups and received esophagoduodenal anastomosis (EDA) surgery plus iron supplementation (12 mg/kg/week). Vitamin E and selenium were supplemented in the diet in the forms of alpha-tocopheryl acetate (750 IU/kg) and sodium selenate (1.7 mg Se/kg), which were 10 times the regular amounts in the basic AIN93M diet. At 40 weeks after surgery, all the EDA groups had lower body weights than the non-operated control group. Iron nutrition (hemoglobin, total serum iron and transferrin saturation) was normal as a result of iron supplementation after EDA. Vitamin E supplementation maintained the normal plasma level of alpha-tocopherol in EDA rats, but not those of gamma-tocopherol and retinol. Selenium supplementation increased the serum and liver selenium contents of the EDA rats. Histopathological analysis showed that selenium supplementation increased the incidence of EAC and the tumor volume. The selenium level in the tumor is higher than that in the duodenum of the same animal. Vitamin E supplementation, however, inhibited carcinogenesis, especially in the selenium-supplemented group. We believe that vitamin E exerts its effect through its antioxidative properties, and a high dose of inorganic selenium may promote carcinogenesis by enhancing oxidative stress.  (+info)

Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids. (5/780)

BACKGROUND: It is generally thought that as the intake of dietary polyunsaturated fatty acids increases, so should that of alpha-tocopherol, to protect the polyunsaturated fatty acids from increased in vivo peroxidation. However, there are little quantitative data about the concentration of alpha-tocopherol that is necessary when eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are consumed. OBJECTIVE: The purpose of this study was to measure changes produced in 2 indexes of lipid oxidation after supplementation with EPA and DHA from fish oil and 3 doses of RRR-alpha-tocopheryl acetate in postmenopausal women. DESIGN: Daily supplements of fish oil providing 2.5 g EPA and 1.8 g DHA and 0, 100, 200, or 400 mg alpha-tocopheryl acetate were given to 46 postmenopausal women in a 4-treatment, 4-period crossover design. RESULTS: The supplements increased plasma concentrations of EPA, DHA, and alpha-tocopherol. The fish-oil supplement increased the plasma concentration of thiobarbituric acid-reactive substances (TBARS) (P: = 0.0001) but not that of oxidatively modified protein, as indicated by the carbonyl content. The alpha-tocopheryl acetate and fish-oil supplements had no significant effect on plasma concentrations of TBARS or oxidized protein. CONCLUSIONS: Although these data show a small but statistically significant increase in oxidative stress on the basis of plasma TBARS concentrations after the consumption of EPA and DHA, the clinical relevance of this change is questionable. In addition, as supplements of alpha-tocopheryl acetate were added to the diet, neither the plasma TBARS concentration nor the protein oxidation changed. Consequently, the results of this study indicate that there is no basis for vitamin E supplementation after consumption of EPA and DHA.  (+info)

Altered susceptibility to ischemia-reperfusion injury in isolated-perfused hearts of short-term diabetic rats associated with changes in non-enzymatic antioxidants. (6/780)

The effects of short-term (2-week) diabetes on myocardial ischemia-reperfusion (I-R) injury and associated changes in myocardial non-enzymatic antioxidant level were examined. Isolated-perfused hearts prepared from control and diabetic rats were subjected to increasing periods of ischemia and reperfusion, and myocardial I-R injury was assessed by measuring the extent of lactate dehydrogenase (LDH) leakage and contractile force recovery. While a brief period (20 min) of post-ischemic reperfusion caused a smaller extent of LDH leakage, the prolonged period (40 min) of reperfusion produced a greater degree of I-R injury in diabetic hearts, as indicated by the impaired recovery of contractile force. The apparent protection against I-R injury in diabetic hearts during the early phase of post-ischemic reperfusion was associated with increases in myocardial reduced glutathione/ascorbic acid and a-tocopherol levels, with the effect on a-tocopherol being most prominent. Insulin treatment could reverse the diabetes-associated changes in susceptibility to myocardial I-R injury and antioxidant response. The ensemble of results indicates that the myocardium isolated from short-term diabetic rat can produce a beneficial antioxidant response to I-R challenge, which may, in turn, be attributable to the decreased susceptibility to I-R injury observable during the early phase of reperfusion.  (+info)

Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. (7/780)

Peroxisome proliferator-activated receptor (PPAR)-gamma ligands thiazolidinediones (TZDs) have recently been reported to be anti-hypertensive and anti-atherosclerotic. We have previously shown that one of the TZDs troglitazone significantly suppressed the transcription of both thromboxane receptor (TXR) and angiotensin II type 1 receptor (AT1R) genes in vascular smooth muscle cells (VSMCs) by activating PPAR-gamma. In the present study, we compared the effects of troglitazone and other TZDs on the transcription of these genes. TXR and AT1R mRNAs in rat VSMCs were determined by semi-quantitative RT-PCR. Luciferase chimeric constructs containing either the 989-bp rat TXR gene promoter or the 1,969-bp rat AT1R gene promoter were transiently transfected into VSMCs. The cells were incubated with troglitazone, RS-1455 (a derivative of troglitazone which does not contain the hindered phenol resembling alpha-tocopherol), pioglitazone, or rosiglitazone for 12 h before harvesting. mRNA expression levels of TXR and AT1R were significantly decreased by troglitazone in contrast to rosiglitazone. TXR gene and AT1R gene transcription was significantly suppressed by troglitazone in a dose-dependent manner, while RS-1455 was less potent. Pioglitazone and rosiglitazone weakly suppressed the transcription of both genes in a manner almost similar to RS-1455. We have shown that troglitazone suppresses transcription of both the TXR and AT1R genes more potently than other TZDs. The structure of troglitazone and RS-1455 is identical except the hindered phenol, which is recently recognized to function as an antioxidant. Moreover, we have shown that the potency for activating PPAR-gamma is almost identical between troglitazone and RS-1455. We therefore speculate that the strong transcriptional suppression of the TXR and AT1R genes by troglitazone may be mediated in part by its antioxidant effect.  (+info)

Evidence of a lysosomal pathway for apoptosis induced by the synthetic retinoid CD437 in human leukemia HL-60 cells. (8/780)

The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid (AHPN/CD437) has been proven to be a potent inducer of apoptosis in a variety of tumor cell types. However, the mechanism of its action remains to be elucidated. Recent studies suggest that the lysosomal protease cathepsin D, when released from lysosomes to the cytosol, can initiate apoptosis. In this study, we examined whether cathepsin D and free radicals are involved in the CD437-induced apoptosis. Exposure of human leukemia HL-60 cells to CD437 resulted in rapid induction of apoptosis as indicated by caspase activation, phosphatidylserine exposure, mitochondrial alterations and morphological changes. Addition of the antioxidants alpha-tocopherol acetate effectively inhibited the CD437-induced apoptosis. Measurement of the intracellular free radicals indicated a rise in oxidative stress in CD437-treated cells, which could be attenuated by alpha-tocopherol acetate. Interestingly, pretreatment of cells with the cathepsin D inhibitor pepstatin A blocked the CD437-induced free radical formation and apoptotic effects, suggesting the involvement of cathepsin D. However, Western blotting revealed no difference in cellular quantity of any forms of cathepsin D between control cells and CD437-treated cells, whereas immunofluorescence analysis of the intracellular distribution of cathepsin D showed release of the enzyme from lysosomes to the cytosol. Labeling of lysosomes with lysosomotropic probes confirmed that CD437 could induce lysosomal leakage. The CD437-induced relocation of cathepsin D could not be prevented by alpha-tocopherol acetate, suggesting that the lysosomal leakage precedes free radical formation. Furthermore, a retinoic acid nuclear receptor (RAR) antagonist failed to block these effects of CD437, suggesting that the action of CD437 is RAR-independent. Taken together, these data suggest a novel lysosomal pathway for CD437-induced apoptosis, in which lysosomes are the primary target and cathepsin D and free radicals act as death mediators.  (+info)

Alpha-tocopherol, a lipid soluble antioxidant, has been shown to protect endothelial cells against oxidative damage (18-21). Previous reports showed that alpha-tocopherol supplementation restored endothelial function in parallel with suppression of lipid peroxidation in low density lipoproteins (LDL) in experimental hypercholesterolemic animals (19,21). In this regard, the present study also showed that the improvement of endothelium-dependent vasodilation was associated with decrease in plasma TBARS levels, an indicator of lipid peroxidation, after alpha-tocopherol treatment in patients with high remnants levels. This strongly suggests that the beneficial effect of alpha-tocopherol, as shown in the present study, was at least partly mediated through prevention of endothelial function from oxidative stress-induced injury in patients with high remnant lipoproteins levels. We have previously shown that oxidatively modified LDL causes endothelial dysfunction and has an important role in ...
TY - JOUR. T1 - Alpha-tocopherol supplementation decreases the oxidative susceptibility of LDL in renal failure patients on dialysis therapy. AU - Islam, Kazi Nazrul. AU - OByrne, Dawn. AU - Devaraj, Sridevi. AU - Palmer, Biff. AU - Grundy, Scott M.. AU - Jialal, Ishwarlal. PY - 2000. Y1 - 2000. N2 - Atherosclerotic cardiovascular disease is the leading cause of death in patients with end stage renal disease (ESRD) who have undergone dialysis treatment. The oxidation of low density lipoprotein (LDL) appears to be a crucial step in the pathogenesis of atherosclerosis. The increased oxidative stress and attendant increased oxidizability of lipoproteins, such as LDL could contribute to the accelerated atherosclerosis in dialysis patients. Since α-tocopherol (AT) is the major antioxidant in LDL, the aim of the present study was to test the effectiveness of RRR-AT supplementation (800 I.U. per day) for 12 weeks on the susceptibility of LDL to oxidation. The study subjects comprised patients with ...
Epidemiological and experimental studies have indicated that dietary factors such as vitamin C, vitamin E, and b ta-carotene are associated with the risk of colorectal cancer. This study was carried out within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study ATBC Study, whose participants were randomly assigned to four...
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Abstract: alpha-Tocopherol reduced distinctly the intensity and duration of the stress reaction. Preadministration of alpha-tocopherol into animals before stress prevented the corticosterone elevation as well as the catecholamine decrease in heart muscle and adrenal glands; at the same time, the vitamin reduced 2-fold the duration of eosinopenia. Besides, the intensity of NA-3N neuronal uptake was twice increased in these tissues ...
Koll, Michael, Patel, Vinood B., Sherwood, R.A., Seitz, H.K., Simanowski, U.A., Richardson, P.J., Peters, T.J. and Preedy, Victor R. (2001) Alpha-Tocopherol supplementation does not prevent acute alcohol-induced heart muscle damage. Proceedings of the Nutrition Society, 60. P125A. ISSN 0029-6651 ...
The human a-tocopherol transfer protein (h-a-TTP) is understood to be the entity responsible for the specific retention of a-tocopherol (a-toc) in human tissues over all other forms of vitamin E obtained from the diet ...
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The original one-room school was established in 1848 by Enoch Turner (1792-1866), a wealthy brewer and philanthropist, to educate the children in the poor neighbourhood surrounding his brewery.[2] Because many of the areas immigrant families were from County Cork in Ireland, the neighbourhood became known as Corktown - a nickname it still carries today.[2] Turner supplied the funds to construct the Schoolhouse and the land was donated by the adjacent Little Trinity Church.[3][2] In 1849, the school opened with space for 240 pupils and Turner paid for its operation for three years.[2] It was the first free school in Toronto.[4][2] Enoch Turner founded his free school following the Common Schools Act of 1846. After the act was passed, municipalities had the power to raise funds for public education through taxation. However, city officials were unwilling to introduce such taxes, and as a result, all schools that benefited from any kind of public support were closed for a year. This prompted ...
Looking for online definition of a-tocopherol in the Medical Dictionary? a-tocopherol explanation free. What is a-tocopherol? Meaning of a-tocopherol medical term. What does a-tocopherol mean?
This page contains the abstract Human Plasma and Tissue Alpha-tocopherol Concentrations in Response to Supplementation with Deuterated Natural and Synthetic Vitamin E http://www.chiro.org/nutrition/ABSTRACTS/Human_Plasma_and_Tissue_Alpha.shtml
The project is a passive follow-up of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort. Originally, this was a large, randomized, double-blind, placebo-controlled, 2x2 factorial primary prevention trial testing the effects of alpha-tocopherol and beta-carotene supplementation on cancer incidence and mortality. The study was conducted in Finland as a collaboration between the U.S. National Cancer Institute (NCI) and the National Public Health Institute of Finland. NCI has maintained passive surveillance of the cohort through Finnish national registries, including the cancer registry.. The primary purpose of the ATBC cohort follow-up is to use the existing risk factor data and biological specimens (i.e., serum, whole blood, DNA, red blood cells, and toenails) to test hypotheses relevant to cancer etiology, survival, early detection, and prevention. These data and biospecimens continue to provide an invaluable resource for the study of biochemical, nutritional, genetic, and ...
Vitamin E has been shown to be beneficial in the prevention of cardiovascular disease (CVD). The following research is concerned with assessing vitamin E status in healthy people and those with increased risk of CVD, who may have an altered vitamin E status. To understand the relationship between vitamin E intake, blood concentrations and metabolism healthy subjects were given varying single doses of RRR alpha-tocopheryl acetate (alpha-TA) up to 780 mg (n=20). There was a greater uptake of alpha-tocopherol in plasma and erythrocytes compared with platelets and lymphocytes. No dose-response relationship was observed, however there was a positive correlation between percentage increase in a-tocopherol concentration in plasma and erythrocyte with mg urinary alpha-carboxyethylhydroxychroman (alpha-CEHC) excreted. Less than 1% of alpha-TA was excreted as urinary a-CEHC. Research into the absorption of deuterium labelled (d6) alpha-TA showed a greater uptake into plasma and chylomicrons over 9 h when ...
OBJECTIVE: The purpose of this study was to compare the effects of castration on cell death rate of the adult rat prostates and to evaluate the benefic action of alpha tocopherol supplementation to avoid apoptosis post-orchiectomy. MATERIAL AND METHODS: Thirty male Wistar rats weighing 250-300g were divided into three groups: group I - they were subjected to bilateral orchiectomy and sacrificed eight weeks after the procedure; group II - subjected to bilateral orchiectomy and alpha-tocopherol supplementation for four weeks preceding the procedure; and group III - subjected to bilateral orchiectomy and alpha-tocopherol supplementation for four weeks preceding the procedure and for eight weeks afterwards ...
MYTH: Natural Vitamins are better for the body than synthetic vitamins.. TRUTH: Not necessarily. In some cases the synthetic vitamin molecule is bio-identical to the same molecule found in nature.. Confusion arises because "natural" and "synthetic" are not opposites. The true opposite of "natural" is "artificial". Synthesis is the process by which new compounds are produced by combining simpler substances, and this can happen either in the body or in a laboratory. Synthetic vitamins can be either natural or artificial.. All synthetic vitamins A, D and E are artificial. Their molecular structures differ slightly from the same vitamins found in nature. All documented cases of toxicity from overdosing on vitamin A appear to have been from consuming artificial vitamin A. There are no documented cases of harm from consuming artificial vitamin E; however, this form of the vitamin is less efficiently utilized by the body than is natural vitamin E.. Synthetic vitamin C and all synthetic B-vitamins, ...
Synthetic vitamin E derived from petroleum products is manufactured as all-racemic alpha tocopheryl acetate with three chiral centers. This mixture has only one alpha tocopherol molecule (moiety) in 8 molecules as actual R, R,R-alpha tocopherol. The 8-isomer "all-rac" vitamin E is always marked on labels simply as "dl-tocopherol" or "dl-tocopheryl acetate", even though it is (if fully written out) actually dl,dl,dl-tocopherol. The present largest manufacturers of this type are DSM and BASF. (An earlier semisynthetic vitamin E actually contained 50% d,d,d-alpha tocopherol moiety and 50% l,d,d-alpha-tocopherol moiety, as synthesized by an earlier process which started with a plant sterol intermediate with the correct chirality in the tail, and thus resulted in a racemic mixture at only one chiral center. This form, known as 2-ambo tocopherol, is no longer made.) Natural alpha-tocopherol is the RRR-alpha (or ddd-alpha) form. The synthetic dl,dl,dl-alpha ("dl-alpha") form is not as active as the ...
Lee, S.-M. and Clemens, M. G. (1992), Effect of α-tocopherol on hepatic mixed function oxidases in hepatic ischemia/reperfusion. Hepatology, 15: 276-281. doi: 10.1002/hep.1840150217 ...
Vitamin E is necessary for ruminants to maintain a well functioning immune system, high reproduction level, and good milk and meat quality. The content of antioxidants in colostrum affects the absorption of antibodies in newborn calves. Selenium content of soils may be low, and thus home-grown forage may be low in selenium. If the roughage is also low in vitamin E, which interacts with the biological effects of selenium, deficiency may easily occur. Therefore, the rations of ruminants must be supplemented with synthetic vitamin E to ensure an adequate intake of vitamin E. However, it is known that 87,5% of the molecules of synthetic vitamin E have a non-natural configuration and is not as effective as biological vitamin E. For this reason it is important to find alternative natural vitamin and antioxidant sources that are cheap and sustainable to produce and easy to handle, especially for the organic livestock production but also for traditional livestock production. It was therefore conducted a ...
Trace amounts of Manganese (Mn) are essential for the proper functioning of a variety of physiological processes, including development, in all living organisms. However, several studies indicate that high Mn levels may be toxic to terrestrial and aquatic organisms, especially due to its neurotoxic properties. In the present study, the young and adult albino rats (2 months and 4 months old) were exposed to low dose (2.5mg/kg body weight) and high dose (5mg/kg body weight) of Mn through intraperitoneal injection for a period of 3 weeks and a separate batch treated with Mn was left for a period of one week supplementation with Alpha-tocopherol at a dose of 5mg/kg body weightalong with Mn until the end of the study.Control animals received only deionized water without Mn. In the present study, it was observed that, the potential effect of Adenosine Triphosphatase (ATPase) activity (EC 3.6.1.3); Mg2+ATPase and Na+K+ ATPase activities were assayed. From our observation, it was cleared that the ...
There are a variety of benefits to taking your Vitamin E. Vitamin E functions to help fat-soluble antioxidants. It helps to protect the cells from damage, and it may also aid in reducing other health issues such as heart disease and cancer, as well as prevention of dementia.. Vitamin E helps to improve the function of the immune system and protects the eyes and the eyesight. A study of the Dept of Epidemiology and Health Statistics of Qingdao University also found that the vitamin intake and the higher serum tocopherol levels have been linked to a lower risk of cataracts due to age.. Vitamin E also functions in creating the hormone prostaglandins which regulates many of the body processes like blood pressure and reproduction, as well as muscle contractions. In recent studies, it also helps to repair the muscles.. For those who are suffering from Crohns disease and cystic fibrosis or even an inability to get rid of the bile in the liver, this may also help them to avoid further issues with their ...
How much of Vitamin E (alpha-tocopherol) is present in Chicken, fryers or broilers, dark meat, meat with skin, raw natural in details, quantity how high or low Vitamin E (alpha-tocopherol) nutrient content it has.
Wrong type of vitamins can increase risk of stroke.Intake of synthetic vitamin can increase it by 30%.So its important to get higher quality vitamin.
Do you know about Alpha-tocopherol? If not, here is a hint: Alpha-tocopherol is important to staying healthy! Read on to find out why.
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In our study, 400 IU/day of RRR-α-tocopheryl acetate administered for an average of 4.5 years to people with diabetes and at high risk for CV events had a neutral effect on CV outcomes, on microvascular complications, and on glycemic control.. The results on CV outcomes are very robust, with a large number of events and with consistent lack of benefit associated with vitamin E therapy on the composite primary outcome, on each component of the primary outcome, and on all secondary and additional CV outcomes for the entire diabetic study population and for all subgroups evaluated.. In spite of the strong biological rationale for a fundamental role of oxidative stress in atherosclerosis and the supportive epidemiological data, randomized clinical trials have overall, with few exceptions, failed to detect clear benefits of vitamin E supplementation on the progression of atherosclerotic lesions or on clinical events (8-11,15,16). While vitamin E was shown to improve endothelial function in ...
Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, Spate VL, Helzlsouer KJ. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acid, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Cancer Epidemiol Biomark Prev. 1997; 6(11): 907-16 ...
Unbalanced Fox news report misleads about vitamin-mineral safety By Neil E. Levin, CCN, DANLA I watched the special health report on vitamins and minerals on FOX-32 (How Do Vitamins and Minerals Really Affect Your Body? on 2/12/08, see link below), but was disappointed that the report exaggerated the risks of vitamins and minerals and minimized their benefits without any mention of the common deficiencies that exist in the American population. For example, the report cautioned about vitamin E causing blood thinning, but the Food and Nutrition Board of the Institute of Medicine has set an upper tolerable intake level (UL) for vitamin E (alpha-tocopherol) at 1,500 IU per day, which "is the highest dose unlikely to result in bleeding problems;" though the Institute has also said that the danger of the vitamin inhibiting clotting was not convincing. In other words, taking about four times the most common strength of even a hi-potency vitamin E capsule might be a problem in terms of affecting ...
In this study, antioxidant biodegradable films based on pea protein and alpha-tocopherol were successfully developed by solution casting. The effect of both the homogenization conditions (rotor-stator and microfluidizer) and the relative humidity (RH) on the microstructure and physical properties (transparency, tensile, oxygen and water vapour barrier properties) of pea protein/alpha-tocopherol-based films was evaluated. The addition of alpha-tocopherol produced minimal changes in the films transparency, while providing them with antioxidant properties and improved water vapour and oxygen barrier properties (up to 30 % in both water vapour and oxygen permeability) when films were at low and intermediate RH. The addition of alpha-tocopherol in microfluidized films gave rise to an increase in their resistance to break and extensibility (up to 27 % in E values) at intermediate and high RH. These results add a new insight into the potential of employing pea protein and alpha-tocopherol in the ...
Semantic Scholar extracted view of A liquid chromatographic method for quantitative determination of alpha-tocopherol in rat brain. by Govind T. Vatassery et al.
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Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort.. Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).. Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend ,0.001; ,276.7 versus ,203.9 mg/dL), and the inverse association was particularly evident for cancers of the lung and ...
Learn more about Vitamin E at Grand Strand Medical Center Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Learn more about Vitamin E at Grand Strand Medical Center Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Learn more about Vitamin E at Regional Medical Center Bayonet Point Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Learn more about Vitamin E at Largo Medical Center Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl.....
Learn more about Vitamin E at Portsmouth Regional Hospital Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Learn more about Vitamin E at Memorial Hospital Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Medical information for Tocopherol on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction.
Internet Numbers RFC 997 Network Numbers R 192.012.024.rrr MICANET MITRE (Experimental) [WDL] R 192.012.025.rrr CSS-GRAMINAE CSS Workstation Net [16,RR2] R 192.012.026.rrr NOSC-NETR Net-R Testbed at BBN [26,CP10] R 192.012.027.rrr UR-LASER UR Laser Energetics [30,WXL] R*192.012.028.rrr RIACS-X-NET RIACS-Experimental-Net [DG28] D 192.012.029.rrr RF-EVANS ADDCOMPE DC3 LAN1 [30,MB31] D 192.012.030.rrr RF-HEX-A ADDCOMPE DC3 LAN2 [30,MB31] D 192.012.031.rrr USNA-ENET USNA Engineering Net [30,TS9] R*192.012.032.rrr CMU-VINEYARD CMU File Cluster Net [30,MXK] R 192.012.033.rrr SRI-CSL-NET SRI-CSL 10MB Ethernet [GEOF] C*192.012.034.rrr-192.012.043.rrr Schlumberger PA Net [30,RXB] R 192.012.044.rrr T NRTC-NET Northrop Research Net [30,RSM1] R 192.012.045.rrr ACC-SB-IMP-NET ACC Santa Barbara IMP [AB20] R 192.012.046.rrr ACC-SB-ETHER ACC Santa Barbara Ethernet[AB20] R 192.012.047.rrr UMN-UCC-NET Univ. of Minnesota [RG12] G 192.012.048.rrr AMES-ED-EXPNET Code ED Exp. Net. [30,MSM1] G 192.012.049.rrr ...
Forty-six Holstein heifer calves were used from birth to 3 rno to study the effect of supplemental vitamin E at 1400 or 2800 mg dl-a.-tocopherol acetate given orally at weekly intervals or 1400 mg dl-a-tocopherol by ...
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[151 Pages Report] Check for Discount on Global Synthetic vitamin E Industry 2016 Market Research Report report by QYResearch Group. The Global Synthetic vitamin E Industry 2016 Market Research Report...
However, it turns out all of these pharmacists were dead wrong on the bodys ability to use synthetic Vitamin E as an antioxidant. The synthetic form of Vitamin E is an isomer of the natural molecule, but the body can readily detect the change. Whereas natural Vitamin E is a powerful antioxidant, the synthetic form of Vitamin E may or may not have any antioxidant properties for any given patient. In fact, a physical chemist at Oak Ridge National Laboratory expressed it to me this way: "The synthetic form of Vitamin E hopefully will not cause harm, but it does little good in the body." The interested reader is encouraged to search on the Internet for web pages describing "synthetic Vitamin E" along with "natural Vitamin E" to find hundreds of web pages decrying the use and efficacy of synthetic Vitamin E.. Most synthetic Vitamin E softgels contain a water-insoluble oil that could conceivably clog arteries similar to very low density lipoproteins (VLDL). When the mainstream news media puts out ...
Food & Beverage Fortification. At the beginning, the report covers the top Mixed Tocopherol manufacturing industry players from regions like United States, EU, Japan, and China. It also characterizes the market based on topographical regions.. Further, the Mixed Tocopherol report gives information on the company profile, market share and contact details along with value chain analysis of Mixed Tocopherol industry, Mixed Tocopherol industry rules and policies, circumstances driving the growth of the market and compulsion blocking the growth. Mixed Tocopherol Market development scope and various business strategies are also mentioned in this report.. To Buy Complete Report Click Here: http://qyresearch.us/report/global-mixed-tocopherol-market-2017. The Mixed Tocopherol research report includes the products that are currently in demand and available in the market along with their cost breakup, manufacturing volume, import/export scheme and contribution to the Mixed Tocopherol market revenue ...
Studies show that natural vitamin E is better than synthetic vitamin E. Alpha-tocopherol is present in natural vitamin E as well as the other types of vitamin E. There is little evidence of the value of delta and beta forms of vitamin E but some researchers agree that gamma tocopherol has the same level of importance with alpha-tocopherol. On the other hand, some studies suggest that gamma tocopherol is more useful than alpha tocopherol in terms of the protection against different kinds of oxidative damage. Some experts say that high dosage of alpha tocopherol may result to the decrease of blood levels and increase of breakdown ...
Our results suggest that the Ala variant of SOD2 Ex2+24T,C (V16A) was associated with a moderately increased risk of prostate cancer in Caucasians, particularly among men with lower intake of dietary and supplemental vitamin E. No significant associations with prostate cancer were observed for polymorphic variants in SOD3 or SOD1. Similar to our study, men homozygous for the SOD2 Ala allele had a 70% increase in risk over men homozygous for the Val allele in Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study conducted for 197 cases and 190 controls (17), whereas no overall association was found in the Physicians Health Study conducted for 567 cases and 764 controls (18).. In our study, the elevation of prostate cancer risk associated with the SOD2 Ala allele was observed particularly for smokers with lower vitamin E intake. We previously reported, in the PLCO Trial, that greater vitamin E intake was associated with lower prostate cancer risk, only in smokers (29), as also reported by ...
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alpha-Tocopherol augmentation in human neutrophils was investigated for effects on neutrophil activation and tyrosine phosphorylation of proteins, through its modulation of protein kinase C (PKC) and tyrosine phosphatase activities. Incubation of neutrophils with alpha-tocopherol succinate (TS) resulted in a dose-dependent incorporation into cell membranes, up to 2.5 nmol/2 X 10(6) cells. A saturating dose of TS (40 mumol/l) inhibited oxidant production by neutrophils stimulated with phorbol myristate acetate (PMA) or opsonized zymosan (OZ) by 86 and 57%, as measured by luminol-amplified chemiluminescence (CL). With PMA, TS inhibited CL generation to a similar extent to staurosporine (10 nmol/l) or genistein (100 mumol/l), and much more than Trolox (40 mumol/l). With OZ, TS inhibited CL to a similar extent to Trolox. Neutrophil PKC activity was inhibited 50% or more by TS or staurosporine. the enzyme activity was unaffected by genistein or Trolox, indicating a specific interaction of ...
Most chemists maintain that molecule by molecule, synthetic vitamins are identical to natural whole food vitamins. The isolated factor of each may be chemically similar, however there are many cofactors and enzymes that occur in foods that make the nutrients work properly in our body that we have not yet even discovered. Man made synthetic supplements are a combination of the separate factors, never the complex of synergistic factors found in nature. The whole family of B, C, or E vitamins is known as a
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The inhibitory effect of 2-O-glycosyl isovitexin (2-O-GIV), isolated from young barley leaves, on glyoxal formation from the oxidative degradation of three fatty acid ethyl esters was measured. Ethyl linoleate, ethyl linolenate and ethyl arachidona
Now Foods E-400 Mixed Tocopherols is a major and critical defensive vitamin that fights against lipid peroxidation. Now Foods Vitamin E is contains 100% natural mixed tocopherols also particularly important in protecting the bodys cells from free radical and oxidative damage.
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In the present study, we determined the effects of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) on the growth and apoptosis of cultured human prostate cancer LNCaP cells. We also determined the effects of dietary γ-TmT on the formation and growth of LNCaP tumors in immunodeficient mice. In the in vitro study, we found that the activity of γ-TmT was stronger than α-tocopherol for inhibiting the growth and stimulating apoptosis in LNCaP cells. In the animal study, treatment of severe combined immunodeficient (SCID) mice with dietary γ-TmT inhibited the formation and growth of LNCaP xenograft tumors in a dose-dependent manner. Mechanistic studies showed that g-TmT administration inhibited proliferation as reflected by decreased mitosis and stimulated apoptosis as reflected by increased caspase-3 (active form) expression in LNCaP tumors. In addition, dietary administration of g-TmT increased the levels of a-, γ- and δ- tocopherol in plasma, and increased levels of γ- and δ- tocopherol were
Ingredients:Vitamin E (as d-Alpha Tocopherol), Mixed Tocopherols (as d-Beta Tocopherol, d-Gamma, Tocopherol, d-Delta Tocopherol), Other Ingredients: Gelatin (softgel), glycerin, soy oilDirections:As a dietary supplement, take 1 softgel daily with a meal or a glass of water.
Following 12 weeks, in vitro aortic endothelial-independent relaxation was enhanced with both α-tocopherol and mixed-tocopherol (P , 0.05), while mixed-tocopherol enhanced aortic contraction at noradrenaline concentrations of 3 × 10−7 M to 3 × 10−5 M (P , 0.05), when compared to normal chow. Supplementation with α- and mixed-tocopherol reduced systemic concentrations of IL-6 (P , 0.001 and P , 0.001, respectively) and IL-10 (P , 0.05 and P , 0.001, respectively), while α-tocopherol also reduced MCP-1 (P , 0.05) and tumor necrosis factor (TNF)-α (P , 0.05). Aortic sinus plaque area was significantly reduced with α-tocopherol supplementation when compared to normal chow (P , 0.01 ...
Université de Liège - ULiège , Département des sciences biomédicales et précliniques , Laboratoire de Biologie des Tissus Conjonctifs , ,] ...
This topic has 1 study abstract on Vitamin E: alpha tocopherol indicating that it may have therapeutic value in the treatment of Oxidative Stress, DNA damage, and Endothelial Dysfunction
Moreover, another form of vitamin E, gamma-tocopherol, also tended to reduce the absorption of the alpha-form, the researchers report in the European Journal of Clinical Nutrition​. The results could force a rethink for vitamin formulations in order to maximise the nutritional quality of the supplements. Presently, alpha-tocopherol is often combined with other antioxidants and other forms of vitamin E. An in vitro study showed that the polyphenol naringenin and a carotenoids mixture (lycopene, beta-carotene and lutein) significantly impaired the absorption of alpha-tocopherol across a cell system model of the intestine (Caco-2 cells). (R,R,R)-alpha-tocopherol is a fat-soluble antioxidant vitamin generally ingested with other dietary antioxidants. The researchers, from Frances Institut National de la Santé Et de la Recherche Médicale (INSERM) U476 in Marseille, followed the in vitro​ study with a small human study with eight male volunteers. The men consumed an alpha-tocopherol-rich meal ...
Gamma-tocotrienol has been reported to exhibit a protective effect on hepatocarcinogenesis through the enhancement of immune response and anti-prolife..
ContextIn the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, α-tocopherol supplementation decreased prostate cancer incidence, wherea
Ultra-Synergist E Mixed tocopherols with high alpha and gamma fractions Alpha and gamma tocopherols have similar but also unique mechanisms, making their activities synergistic. Both offer important antioxidant support for lipid membranes. Long-term supplementation with d-alpha tocopherol supports prostate health, as indicated in a recent study. In a separate case-control study, high intake of gamma tocopherol was also positively associated with prostate health. In addition, gamma tocopherol in this study optimized the ability of alpha tocopherol to support the prostate. Both alpha and gamma tocopherols support arterial smooth muscle cells. In one study, gamma tocopherol provided an enhanced ability to maintain healthy nitric oxide metabolism compared to alpha tocopherol. The same study suggested that gamma tocopherol promoted greater superoxide dismutase activity in plasma and vascular tissue. In an in vitro investigation of human macrophage and epithelial cells, gamma tocopherol supported healthy
The objective of this study is to verify, through a randomized, single-blind, multicentre, parallel and comparative study, the effectiveness of heparin sodium of porcine origin in patients undergoing heart surgery that require the aid of cardiopulmonary bypass. The effectiveness will be determined through the control of hemostasis during and after surgery, based on the strengths of markers of coagulation trichloroacetic acid (TCA), alpha-tocopherol transfer protein (TTPA), Anti-Xa, heparin bioavailability and excessive loss of blood (bleeding) at the end of the surgery ...
Solaray Bio E + C with Mixed Tocopherols - 60 VCaps: Offering the entire line of Solaray and Nutraceutical vitamins, minerals, and supplements. Free shipping on orders over $100!
Global Mixed Tocopherols market is anticipated to grow at 5.4% CAGR from 2016 to 2021 and it is estimated that the global market was valued at USD 4.05 billion in 2016 and is expected to reach USD 5.27 billion by 2021.
Carlson Laboratories began with a single vitamin E formula and a mission. The Carlson family knew firsthand about this powerful antioxidant, especially in the alpha-tocopheryl succinate form. They started Carlson Laboratories after seeing the health benefits Susan Carlsons father experienced from taking this form of vitamin E. They wanted to share with everyone the health benefits their family found using naturally sourced vitamin E.. Since then, the product line has grown to become the most complete line of natural-source vitamin E products in the world. Carlsons product range has continued to expand through the years to meet the nutritional needs of its customers. Carlson was one of the first companies to understand the important health benefits of omega-3s contained in fish oils and introduce them to the North American market in 1982. Since then, theyve become renowned for their award-winning, great-tasting Norwegian fish oils.. Today, the next generation of the Carlson family continues to ...
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phytol: An organic compound used in the manufacture of synthetic vitamins E and K 1. Phytol was first obtained by hydrolysis (decomposition by water) of chlorophyll in 1909 by the German...
The independent and joint associations of serum selenium and vitamin A (retinol) and E (alpha tocopherol) concentrations with the risk of death from cancer were studied in 51 case-control pairs--that is, 51 patients with cancer, each paired with a control matched for age, sex, and smoking. Case-control pairs came from a random sample of some 12000 people aged 30-64 years resident in two provinces of eastern Finland who were followed up for four years. Patients who died of cancer during the follow up period had a 12% lower mean serum selenium concentration (p = 0.015) than the controls. The difference persisted when deaths from cancer in the first follow up year were excluded. The adjusted risk of fatal cancer was 5.8-fold (95% confidence interval 1.2-29.0) among subjects in the lowest tertile of selenium concentrations compared with those with higher values. Subjects with both low selenium and low alpha tocopherol concentrations in serum had an 11.4-fold adjusted risk. Among smoking men with ...
What Is It? Ultra-Synergist E provides a broad spectrum of mixed tocopherols with high alpha and gamma fractions.. Uses For Ultra-Synergist E. Antioxidant Support: One study suggested that both alpha and gamma tocopherols promoted superoxide dismutase activity in plasma and vascular tissue. Multiple studies indicate that both fractions offer antioxidant support for lipid membranes, helping to protect their structural integrity.*. Prostate Health: A case-control study reported that high intake of gamma tocopherol was positively associated with prostate health, while another study indicated that d-alpha tocopherol supports prostate health. It has been suggested that the presence of gamma tocopherol may optimize the effects of alpha tocopherol.*. Cardiovascular Function: A clinical trial revealed that a mixture of alpha, gamma and delta isomers was more effective than any single tocopherol in promoting healthy platelet function. One study suggested that gamma tocopherol modulates some aspects of ...
Learn more about Vitamin E at Medical City Dallas Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
Learn more about Vitamin E at Medical City Dallas Supplement Forms/Alternate Names Alpha Tocopherol D-Tocopherol DL-Tocopherol DL-Alpha-Tocopherol Tocopheryl...
One of the best ways to understand why most published nutritional studies in Conventional Medicine are not helpful is precisely because the only nutrients that interests the Industry and conventional research are isolated nutrients, thanks to which they can be synthesized and patented for cash flow. However, contrarily to whole foods, isolated nutrients act like drugs with side toxic effects. Even many dietary supplements that are considered healthy by integrative doctors can have deleterious effects. Consider the findings of the effects of beta carotene and alpha-tocopherol supplements on lung cancer.. "We found no reduction in the incidence of lung cancer among male smokers after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene. In fact, this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects". (Source). In effect, those taking the pills got more lung cancer than those who didnt, and there were more ...
A vitamin e deficiency affects overall health and proper skin care. Fortunately, for the most part, a deficiency of vitamin e is rare in humans.
Save 50% Lindberg - E - 400 IU 360 Softgels E - 400 IU Plus Mixed Tocopherols Natural d-Alpha Form of Vitamin E Provides Antioxidant Support* Vitamin E is a powerful fat-soluble vitamin and universal antioxidant. It helps protect cells from damage caused by free radicals.* We use only the natural d-alpha tocopherol form of vitamin E and include gamma, delta and beta tocopherols for maximum effectiveness. Our vitamin E may be up to twice as active as synthetic E.
Save 54% Lindberg - E - 1,000 IU 90 Softgels E - 1,000 IU Plus Mixed Tocopherols Natural d-Alpha Form of Vitamin E Provides Antioxidant Support* Vitamin E is a powerful fat-soluble vitamin and universal antioxidant. It helps protect cells from damage caused by free radicals.* We use only the natural d-alpha tocopherol form of vitamin E and include gamma, delta and beta tocopherols for maximum effectiveness. Our vitamin E may be up to twice as active as synthetic E.*
Elle just received the results of a recent Vitamin E test which indicates her Delta & Gamma levels are low: Delta-tocopherol 43.5 nmol/l...
SORILUX Foam contains calcipotriene, a synthetic vitamin D analog that has a similar receptor binding affinity as natural vitamin D
We offer this vitamin and mineral complex because there has been a great deal of research showing that use of synthetic vitamins, which almost all vitamins are, is harmful to your health. Following is a brief description...
We offer this vitamin and mineral complex because there has been a great deal of research showing that use of synthetic vitamins, which almost all vitamins are, is harmful to your health. Following is a brief description...
Susan OBrien is an expert in the raw food movement. She swears by the healing power of good food. She discovered there are a lot of raw foodists who eat for functional reasons only, but Susan was determined to seek out recipes that taste good (and not like bird food). So she studied culinary trained raw foodists like Mathew Kenney, who inspired her tremendously. Her goal is to share this new way of eating with the world. She could not buy this food anywhere in Texas, so she set about to create Hail Merry. So into this paradigm shift of how America thinks about food she went! She is now more than ever determined to bring forth more snacking options free of synthetic vitamins, heat extracted oils, gluten and soy fillers that are found in many so-called health bars and snacks. Hail Merry! www.hailmerry.com. Susan OBrienFounder, Hail Merry ...
Most commonly, additives are included to slow spoilage, prevent fats and oils from going rancid, prevent fruits from turning brown, fortify or enrich the food with synthetic vitamins and minerals to replace the natural ones that were lost during processing, and improve taste, texture and appearance. When reading product packages, here are some of the most common food additives1 to watch out for ...
Background Vitamin E is the name given to a group of water-insoluble, plant-derived substances. There are eight naturally-occurring isomers and a number of semisynthetic or synthetic homologues. The naturally-occurring d- (or RRR) alpha-tocopherol is the
COLOR=darkgreen]Thats the way I see it too, at least as of the summer of 2008. But I think the day is coming soon when that will change, at least as far as achieving partial prevention :angel: (or proving to be a highly discouraging bust! :(. The best shot is probably the SELECT trial, a very large (35, 534 enrolled), long term (12 years of follow-up intended for each enrollee), placebo controlled, randomized, double-blind (neither patient nor patients trial coordinator knows which part of the study he is in) trial of selenium, vitamin E (alpha tocopherol), a combination of both, or neither (the placebo). Enrollment was completed in June 2004, and interim analyses are planned at the 5, 7, 9 and 11 years of follow-up points. To me that suggests the first interim analysis will be done about five years after June 2004, or about this time next year, with the final about 2015. Im hoping an interim report will be published and not just used for trial monitoring. This trial is designed to provide ...
Attitudes of the patients and their families cialis over the counter at walmart reviews towards cancellation of anesthesia and surgery in hypertensive patients. Seasonal variation of serum concentrations of beta-carotene and alpha-tocopherol. Intellectual capacity and BMI (kg/m(2)) were measured at age ...
Fat-soluble organic compound found principally in certain plant oils and leaves of green vegetables Consists of eight chemical forms but only alpha-tocopherol meets human requirement. Functions in the Body. Slideshow 4248593 by clodia
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TY - JOUR. T1 - Comparison of the antioxidant effects of Concord grape juice flavonoids and α-tocopherol on markers of oxidative stress in healthy adults. AU - OByrne, Dawn J.. AU - Devaraj, Sridevi. AU - Grundy, Scott M.. AU - Jialal, Ishwarlal. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Background: Concord grape juice (CGJ) is a rich source of flavonoids, which have greater antioxidant efficacy in vitro than does α-tocopherol; however, the efficacies of flavonoids and α-tocopherol in vivo have not been compared. Objective: We compared the in vivo antioxidant efficacy of CGJ with that of α-tocopherol in healthy adults. Design: Subjects were randomly assigned to receive either 400 IU RRR-α-tocopherol/d (n = 17) or 10 mL CGJ · kg-1 · d-1 (n = 15) for 2 wk. Serum oxygen radical absorbance capacity, plasma protein carbonyls, urinary F2-isoprostanes, and resistance of LDL to ex vivo oxidation were measured before and after supplementation as markers of antioxidant status and oxidative stress. ...
Vitamin E Mixed Tocopherols Natural Vitamin E Complex 400 IU 250 Softgels Vitamin E is a fat-soluble nutrient with powerful antioxidant properties.
Global Mixed Tocopherols Market is expected to reach USD 11.9 billion by 2025, according to a new report by Grand View Research, Inc. Rising vitamin E demand in food and dietary supplements owing to rising health concerns is expected to plays a significant role in promoting the industry growth over the next few years. The global market is anticipated to observe sluggish growth at a CAGR of 2.4% from 2017 to 2025.. Alpha rich tocopherols was the leading product segment and is anticipated to grow at a CAGR of 2.3%, by revenue, over the forecast period. The segment is expected to gain share over the forecast period owing to high demand in dietary supplements. Health benefits associated with vitamin E to treat deficiency and diseases such as lung, oral, colorectal and pancreatic cancer; polyps, and gastric are also anticipated to drive the mixed tocopherols market in pharmaceuticals over the forecast period.. Full Research Report on Global Mixed Tocopherols Market Analysis ...
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BACKGROUND: Evidence of the chemopreventive effects of the dietary antioxidants alpha-tocopherol (vitamin E) and l-selenomethionine (selenium) comes from secondary analysis of two phase III clinical trials that found treatment with these antioxidants reduced the incidence of prostate cancer. To determine the effects of selenium and vitamin E in blood and prostate tissue, we undertook a preoperative feasibility study complementary to the currently ongoing Selenium and Vitamin E Cancer Prevention Trial. METHODS: Forty-eight patients with clinically localized prostate cancer enrolled on this 2 x 2 factorial design study were randomized to take selenium, vitamin E, both, or placebo for 3 to 6 weeks before prostatectomy. Sera were collected from patients before and after dietary supplementation. Thirty-nine patients were evaluable, and 29 age-matched disease-free men served as controls. Mass profiling of lipophilic serum proteins of lower molecular weight (2-13.5 kDa) was conducted, and mass spectra data
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SunnyGrain is a brand-new and leading manufacturer of natural VE and phytosterol in China. And its output of natural vitamin E ranks top throughout all the Chinese natural vitamin E manufacturers. SunnyGrain has the confidence to give you the best service you need ...
Natural Vitamin E is a medicine available in a number of countries worldwide. A list of US medications equivalent to Natural Vitamin E is available on the Drugs.com website.
Author: Written by Rivera, J. D., G. C. Duff, M. L. Galyean, D. A. Walker, and G. A. Nunnery Journal: Journal of Animal Science: 2002 80: 933-941.. Abstract: Three experiments were conducted to examine the effect of dietary vitamin E on receiving performance and health and on finishing performance of beef cattle. One hundred twenty beef steers (Exp. 1; initial BW = 173 kg) and 200 beef heifers (Exp. 2; initial BW = 204 kg) were assigned randomly to one of three treatment diets formulated to supply 285, 570, or 1,140 IU/animal daily of supplemental vitamin E during the receiving period.Average daily gain, gain:feed, and DMI were calculated every 14 d, with pen as the experimental unit. Morbidity and retreatment data were analyzed using a nonparametric procedure. After the receiving period, cattle were assigned to a grazing period followed by a finishing program and fed until slaughter. In Exp. 3, 17 beef steers were used to evaluate effects of the same three vitamin E levels on humoral immune ...
Alpha-carotene 1.6E-29 g Alpha-Tocopherol 8.7E-16 g ... Delta-tocopherol 1.04E-15 g Vitamin C, B-Vitamins, Niacin, ...
Alpha-tocopherol transfer protein. Vitamin D. *liver (Sterol 27-hydroxylase or CYP27A1) ... renal (25-Hydroxyvitamin D3 1-alpha-hydroxylase or CYP27B1). *degradation (1,25-Dihydroxyvitamin D3 24-hydroxylase or CYP24A1) ...
Alpha-tocopherol transfer protein. Vitamin D. *liver (Sterol 27-hydroxylase or CYP27A1) ... Four alpha helices connect successive beta strands.[10] Residues 9 - 24 are termed "Met20" or "loop 1" and, along with other ... renal (25-Hydroxyvitamin D3 1-alpha-hydroxylase or CYP27B1). *degradation (1,25-Dihydroxyvitamin D3 24-hydroxylase or CYP24A1) ...
Alpha-tocopherol transfer protein. Vitamin D. *liver (Sterol 27-hydroxylase or CYP27A1) ... renal (25-Hydroxyvitamin D3 1-alpha-hydroxylase or CYP27B1). *degradation (1,25-Dihydroxyvitamin D3 24-hydroxylase or CYP24A1) ... have shown that gephyrin also interacts with the intracellular loop between the transmembrane helices TM3 and TM4 of alpha and ...
Vitamin E, alpha-tocopherol (mg) 0.49 0.11 1.01 0.01 0.19 0 0.26 0.39 0 0.14 15 ... Carotenoid compounds include provitamin A alpha-carotene and beta-carotene, which are converted to the essential nutrient, ...
Manor D, Morley S (2007). "The alpha-tocopherol transfer protein". Vitam. Horm. 76: 45-65. doi:10.1016/S0083-6729(07)76003-X. ... caused by mutations in the gene for the tocopherol transfer protein. These individuals have an extremely poor capacity to ... Familial isolated vitamin E deficiency Tocopherol Brigelius-Flohé R, Traber MG (July 1999). "Vitamin E: function and metabolism ...
... alpha-tocopherol, lutein/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, trans-beta-carotene, and four retinyl esters ... Azzi A (July 2007). "Molecular mechanism of alpha-tocopherol action". Free Radical Biology & Medicine. 43 (1): 16-21. doi: ... "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. ... Vitamin E (tocopherols, tocotrienols) Vegetable oils, nuts, and seeds Carotenoids (carotenes as provitamin A) Fruit, vegetables ...
TTPAL: encoding protein Tocopherol (alpha) transfer protein-like. *UCKL1: encoding enzyme Uridine-cytidine kinase-like 1 ...
Tocopherol (alpha) transfer protein-like is a protein that in humans is encoded by the TTPAL gene. GRCh38: Ensembl release 89: ...
The synthetic form contains eight different stereoisomers and is called 'all-rac'-α-tocopherol. alpha-Tocopherol is a lipid- ... Shute, W. E.; Shute, E. V.; et al., Alpha Tocopherol (Vitamin E) in Cardiovascular Disease. Toronto, Ontario, Canada: Ryerson ... Gerloczy F (1949). "Clinical and pathological role of d, 1-alpha tocopherol in premature infants; studies on the treatment of ... γ-Tocopherol can be found in corn oil, soybean oil, margarine, and dressings. α-tocopherol, the most biologically active form ...
Kohar I, Baca M, Suarna C, Stocker R, Southwell-Keely PT (Aug 1995). "Is alpha-tocopherol a reservoir for alpha-tocopheryl ...
Teupser D, Thiery J, Seidel D (1999). "Alpha-tocopherol down-regulates scavenger receptor activity in macrophages". ...
The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994). "The effect of vitamin E and beta carotene on the ... Carotenes are found in plants in two primary forms designated by characters from the Greek alphabet: alpha-carotene (α-carotene ... α-tocopherol) and the incidence of lung cancer. The study was done using supplements and researchers were aware of the ...
The Alpha-Tocopherol, Beta Carotine Cancer Prevention Study Group (1994). "The effect of vitamin E and beta carotine on the ... The free radical theory of aging implies that antioxidants such as vitamin A, vitamin C, vitamin E (alpha-tocopherol), beta- ...
Ikeda S, Tohyama T, Yoshimura H, Hamamura K, Abe K, Yamashita K (February 2003). "Dietary alpha-tocopherol decreases alpha- ... Tocotrienols are members of the vitamin E family: four tocotrienols (alpha, beta, gamma, delta) and four tocopherols (alpha, ... Various studies have shown that alpha-tocopherol interferes with tocotrienol benefits. High levels of α-tocopherol increase ... October 1993). "Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the ...
Alpha-tocopherol is the main form in which vitamin E is consumed. Recent studies showed that some tocotrienol isomers have ... Vitamin E, including tocotrienol and tocopherol, is fat soluble and protects lipids. Sources include wheat germ, seabuckthorn, ... Alpha-carotene - found in carrots, winter squash, tomatoes, green beans, cilantro, Swiss chard Astaxanthin - found naturally in ...
Rokitzki L. "Alpha-tocopherol supplementation in racing cyclist during extreme endurance training". International Journal of ...
Vitamin E, alpha-tocopherol (mg) 0.49 0.11 1.01 0.01 0.19 0 0.26 0.39 0 0.14 15 ... Country code; ISO 3166-1 alpha-3, oth 86; other 86 countries. Top 8 countries produced 94.82% in 2016. ... alpha amylase inhibitor, trypsin inhibitors, and prolamin storage proteins of cereals and grasses.[28] ...
Vitamin E, alpha-tocopherol (mg) 0.49 0.11 1.01 0.01 0.19 0 0.26 0.39 0 0.14 15 ...
Azzi (2007). "Molecular mechanism of alpha-tocopherol action". Free radical biology & medicine 43 (1): 16-21. PMID 17561089. ... "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. ... Bin, Q; Hu, X, Cao, Y, Gao, F (2011 Apr). "The role of vitamin E (tocopherol) supplementation in the prevention of stroke. A ... Atkinson; Epand, RF; Epand, RM (2008). "Tocopherols and tocotrienols in membranes: a critical review". Free radical biology & ...
... and alpha-tocopherol (a form of vitamin E) (5 studies) content; milk studies reported on beta-carotene (4 studies) and alpha- ... alpha-tocopherol in pork or beef, or vitamin A (retinol) in beef. The authors analyzed 11 other nutrients reported in studies ... tocopherol levels (4 studies). Few studies examined vitamin content in meats, but these found no difference in beta-carotene in ... α-tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- ...
Other members of the family are alpha-tocopherol transfer protein and phosphatidylinositol-transfer protein (Sec14). They ... "Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E ... alpha-tocopherol and phosphatidylinositol or phosphatidylcholine, respectively) between different intracellular membranes. ... The structure contains several alpha helices as well as a beta sheet composed of 6 strands. Strands 2,3,4 and 5 form a parallel ...
"The Isolation from Cottonseed Oil of an Alcohol Resembling Alpha Tocopherol from Wheat Germ Oil". Science. 83 (2157): 421. doi: ... Evans, H. M.; Emerson, O. H.; Emerson, G. A. (2009). "THE ISOLATION FROM WHEAT GERM OIL OF AN ALCOHOL, α-TOCOPHEROL, HAVING THE ... Emerson, O. H.; Emerson, G. A.; Evans, H. M. (1939). "The Occurrence of Gamma Tocopherol in Corn Embryo Oil". Science. 89 (2304 ... a-tocopherol, having the properties of vitamin E". Journal of Biological Chemistry. 113 (1): 319-332. ...
2008). "Effect of alpha-tocopherol and beta-carotene supplementation on the incidence of type 2 diabetes". Diabetologia. 51 (1 ... Three vitamins, ascorbic acid; α-tocopherol; and β-carotene, are well recognized for their antioxidant activities in human. ...
The authors found 4 studies on each of beta-carotene and alpha-tocopherol levels in milk; differences were heterogeneous and ...
Peptidylglycine alpha-amidating monooxygenase amidates peptide hormones by removing the glyoxylate residue from their c- ... Eipper BA, Stoffers DA, Mains RE (1992). "The biosynthesis of neuropeptides: peptide alpha-amidation". Annual Review of ... "Peptidylglycine alpha-amidating monooxygenase: a multifunctional protein with catalytic, processing, and routing domains" ...
Drug Information available for: alpha-Tocopherol Tocopherol alpha-Tocopherol succinate Tocopherol acetate DL-alpha-Tocopherol ... Tocopherols. Tocotrienols. alpha-Tocopherol. Micronutrients. Growth Substances. Physiological Effects of Drugs. Antioxidants. ...
α-tocopherol (CHEBI:18145) is a α-tocopherol (CHEBI:22470) (+)-α-tocopherol (CHEBI:18145) is enantiomer of (−)-α-tocopherol ( ... 13-hydroxy-α-tocopherol (CHEBI:84962) has functional parent (+)-α-tocopherol (CHEBI:18145). (−)-α-tocopherol (CHEBI:46430) is ... via alpha-tocopherol ). fat-soluble vitamin Vitamins like A, D, E and K that dissolve in fats and are stored in body tissues. ... via alpha-tocopherol ). food antioxidant An antioxidant that used as a food additives to help guard against food deterioration. ...
Functional activity of alpha-tocopherol. The function of alpha tocopherol is as a fat-soluble antioxidant, which breaks the ... Sources of tocopherols. Tocopherols are found in almost all plant seeds, the best sources of alpha-tocopherol include plant ... Alpha-tocopherol esters in supplements are chiefly succinate and acetate, and these are converted to alpha-tocopherol in the ... called alpha, beta, gamma and delta tocopherol respectively. The form used in the human body is alpha tocopherol, and this form ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research ...
RRR-α-tocopherol is the natural one. Older name of RRR-α-tocopherol is d-α-tocopherol, but this d/l naming should be no longer ... α-Tocopherol is a type of tocopherol or vitamin E. It has E number "E307". α-Tocopherol is a form of vitamin E that is ... There are three stereocenters in alpha-tocopherol, so it is a chiral molecule. The eight stereoisomers of α-tocopherol differ ... The SRR may be named 2-epi-α-tocopherol, the diastereomeric mixture of RRR-α-tocopherol and 2-epi-α-tocopherol may be called 2- ...
alpha-tocopherol synonyms, alpha-tocopherol pronunciation, alpha-tocopherol translation, English dictionary definition of alpha ... tocopherol. n. An alcohol, C29H50O2, that is one of the components of vitamin E and is present in vegetable oils, nuts, and ... Alpha-tocopherol - definition of alpha-tocopherol by The Free Dictionary https://www.thefreedictionary.com/alpha-tocopherol ... alpha-tocopherol. Also found in: Thesaurus, Medical, Encyclopedia. al·pha-to·coph·e·rol. (ăl′fə-tō-kŏf′ə-rôl′, -rōl′). n.. An ...
Products containing TOCOPHEROL, D-ALPHA- made by company: Subversive Apothecary There are no products in the database that ...
Alpha-tocopherol transfer protein is a protein that in humans is encoded by the TTPA gene. Familial isolated vitamin E ... "Entrez Gene: TTPA tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)". Gotoda T, Arita M ... Arita M, Sato Y, Miyata A, Tanabe T, Takahashi E, Kayden HJ, Arai H, Inoue K (Apr 1995). "Human alpha-tocopherol transfer ... 1996). "Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency". Ann. Neurol. ...
Topical tocopherol did not normalize established sun-induced lesions, but DL-alpha-tocopherol-induced reductions in polyamine ... Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol.. Foote JA1, Ranger-Moore JR, Einspahr JG, Saboda K, ... Topically applied DL-alpha-tocopherol was substantially absorbed in skin, but the 6-month application did not significantly ... Prior research shows that topical application of free, nonfatty acid-conjugated vitamin E (DL-alpha-tocopherol) prevents skin ...
alpha-tocopherol transfer protein. Names. alpha-TTP. tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin ... TTPA alpha tocopherol transfer protein [Homo sapiens] TTPA alpha tocopherol transfer protein [Homo sapiens]. Gene ID:7274 ... alpha tocopherol transfer proteinprovided by HGNC. Primary source. HGNC:HGNC:12404 See related. Ensembl:ENSG00000137561 MIM: ... XM_006716468.4 → XP_006716531.1 alpha-tocopherol transfer protein isoform X1. Conserved Domains (2) summary. smart01100. ...
alpha-TOCOPHEROL EXPLANATION alpha-Tocopherol and mixed tocopherol concentrate were evaluated for acceptable daily intake at ... of 300 mg alpha-tocopherol daily. Incidences of allergic reactions seem to be very rare. alpha-Tocopherol may be an essential ... alpha-tocopherol (Carpenter, 1972), and d-alpha-tocopherol acetate given as a single oral dose or in 3 consecutive daily doses ... alpha-tocopherol (Shute, 1938). Effects of alpha-tocopherol on some biochemical parameters have been reported in man. A group ...
... alpha tocopherol indicating that it may have therapeutic value in the treatment of Oxidative Stress, DNA damage, and ... 1 Abstracts with Vitamin E: alpha tocopherol & Cancer Mortality Research. [x] Remove Focus on Cancer Mortality. Filter by Study ... 73 Pharmacological Actions Researched for Vitamin E: alpha tocopherol Name. AC. CK. Focus. ... Substances : Carotenoids, Fruit: All, Vegetables: All , Vitamin C, Vitamin E: alpha tocopherol ...
... alpha tocopherol indicating that it may have therapeutic value in the treatment of Oxidative Stress, DNA damage, and ... 73 Pharmacological Actions Researched for Vitamin E: alpha tocopherol Name. AC. CK. Focus. ... 1 Abstracts with Vitamin E: alpha tocopherol & Photorefractive Keratectomy Research. [x] Remove Focus on Photorefractive ... 312 Diseases Researched for Vitamin E: alpha tocopherol Name. AC. CK. Focus. ...
... (vitamin E) is listed as an ingredient in Natpro. From what ... Dl-Alpha Tocopherol. Hello,. I have a question. Natpro claim it is a "natural organic cream." Dl-alpha tocopherol (vitamin E) ... Dl-Alpha Tocopherol by: Wray Hi there Unfortunately natural vitamin E cannot be used as an in vitro antioxidant, it doesnt ... From what I have read, dl-alpha tocopherol a synthetic form of vitamin E. How can it be listed as a "natural" ingredient? Just ...
Tocopherols. Vitamin E. Tocotrienols. alpha-Tocopherol. Carotenoids. Beta Carotene. Antioxidants. Molecular Mechanisms of ... Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. The safety and scientific validity of this study is the ... Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of ... Kataja-Tuomola M, Sundell JR, Männistö S, Virtanen MJ, Kontto J, Albanes D, Virtamo J. Effect of alpha-tocopherol and beta- ...
Serum alpha-tocopherol levels seemed to modify the association between urinary 8-iso-PGF(2 alpha) and BMD. Men with alpha- ... In 405 men, urinary 8-iso-PGF(2 alpha) and serum alpha-tocopherol were measured at age 77 years and BMD at age 82 years. One SD ... Oxidative stress and bone mineral density in elderly men: antioxidant activity of alpha-tocopherol.. Ostman B, Michaëlsson K, ... tocopherol levels below the median combined with high oxidative stress, i.e., 8-iso-PGF(2 alpha) above the median, had 7% (95% ...
The alpha-TTP-mediated transfer of alpha-tocopherol into nascent VLDL is the major determinant of plasma alpha-tocopherol ... Alpha-tocopherol transfer protein (alpha-TTP) is a liver protein responsible for the selective retention of alpha-tocopherol ... The selectivity of alpha-TTP for RRR-alpha-tocopherol is explained from the van der Waals contacts occurring in the lipid- ... Mutations in the alpha-TTP gene have been detected in patients suffering from low plasma alpha-tocopherol and ataxia with ...
We have examined the effect of alpha-tocopherol (alpha-tcp) on one cellular event in atherosclerotic plaque development, ... Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.. ... Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.. ... and concentration-dependent manner by alpha-tcp. The IC50 of alpha-tcp on an IL-1-induced response was 45 microM. The ...
A11HA03 - Tocopherol (Vitamin E). Pharmaceutical companies: manufacturers, researchers, developers, local distributors and ...
... Author(s). Grievink, L.; Waart, F.G. de; Schouten, ... Serum carotenoids, -tocopherol, and lung function among Dutch elderly.. Comments. There are no comments yet. You can post the ... Subjects in the highest quintile of the other carotenoids or -tocopherol did not have significantly higher FEV1 or FVC compared ... In conclusion, this study shows that from the six major serum carotenoids and -tocopherol studied, particularly -carotene, - ...
Alfa-Tocopherol indications, usages and related health products lists ... Alfa-Tocopherol information about active ingredients, pharmaceutical forms and doses by Nizhpharm, ... A11HA03 - Tocopherol (Vitamin E). Pharmaceutical companies: manufacturers, researchers, developers, local distributors and ... Find online pharmacy, drugstore, pharma or beauty shop where to order or buy Alfa-Tocopherol brand or generic online:. ...
The Alpha-Tocopherol Beta-Carotene Cancer Prevention (ATBC) Study was a large randomized, double-blind, placebo-controlled, 2x2 ... Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study (ATBC Study) Population. Trial Phase:. N/A. Minimum Age:. 50 Years ... Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study (ATBC Study) Population. The ATBC study was a randomized, double- ... a-tocopherol as dl-a-tocopheryl acetate (50 mg/day), (Beta)-carotene as. all-trans-(Beta)-carotene (20 mg/day), both ...
Return to Dl-Alpha Tocopherol.. Join in and write your own page! Its easy to do. How? Simply click here to return to ...
In the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, alpha-tocopherol supplementation decreased ... In the ATBC Study, 29 133 male smokers aged 50 to 69 years received alpha-tocopherol (50 mg), beta-carotene (20 mg), both ... To analyze postintervention effects of alpha-tocopherol and beta-carotene on cancer incidence and total and cause-specific ... For prostate cancer incidence (n = 672), the RR was 0.88 (95% CI, 0.76-1.03) for participants receiving alpha-tocopherol ...
As D-Alpha Tocopherol Plus Mixed Tocopherols, 1000 IU, Softgels Solgar Natural Vitamin E, As D-Alpha Tocopherol Plus Mixed ... Natural Vitamin E, As D-Alpha Tocopherol Plus Mixed Tocopherols, 1000 IU, Softgels. ... Natural Vitamin E, As D-Alpha Tocopherol Plus Mixed Tocopherols, 1000 IU, Softgels ... Soybean Oil, Gelatin, Glycerin, D-Gamma Tocopherol, D-Delta Tocopherol, Safflower Oil, D-Beta Tocopherol, Water. ...
  • Like tocopherols, individual tocotrienol isomers demonstrate different bioavailability and efficacy depending on the type of antioxidant performance being measured. (wikipedia.org)
  • All tocotrienol and tocopherol isomers have some physical antioxidant activity due to an ability to donate a hydrogen atom (a proton plus electron) from the hydroxyl group on the chromanol ring, to free radical and reactive oxygen species. (wikipedia.org)
  • Men with alpha-tocopherol levels below the median combined with high oxidative stress, i.e., 8-iso-PGF(2 alpha) above the median, had 7% (95% CI 3-11%) lower BMD at the lumbar spine and 5% (95% CI 2-9%) lower BMD at the proximal femur. (nih.gov)
  • Stocker, "Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation," Arteriosclerosis, Thrombosis, and Vascular Biology, vol. (thefreedictionary.com)
  • The relationship between α-tocopherol, a known antioxidant, and polyunsaturated fatty acid (PUFA) oxidation, has not been directly investigated in the primate brain. (mdpi.com)
  • This study characterized the membrane distribution of α-tocopherol in brain regions and investigated the association between membrane α-tocopherol and PUFA content, as well as brain PUFA oxidation products. (mdpi.com)
  • α-tocopherol, PUFAs, and PUFA oxidation products were measured using high performance liquid chromatography (HPLC), gas chromatography (GC) and liquid chromatography-gas chromatography/mass spectrometry (LC-GC/MS) respectively. (mdpi.com)
  • This study reports novel data on α-tocopherol accumulation in primate brain regions and membranes and provides evidence that α-tocopherol and AA are similarly distributed in PFC and ST membranes, which may reflect a protective effect of α-tocopherol against AA oxidation. (mdpi.com)
  • Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis. (ahajournals.org)
  • Maximum inhibition of 82% was obtained from oxidation of ethyl arachidonate at 8 mumol 2"-O-GIV, whereas maximum inhibition of 77% was observed from oxidation of ethyl arachidonate at 0.25 mumol alpha-tocopherol. (biomedsearch.com)
  • Polylactic Acid (PLA) films prepared with the same amount of alpha-tocopherol were used to set a comparative frame and both types of films were applied to two different food models to assess their protective action against oxidation. (upc.edu)
  • Primary oxidation was measured with peroxide value, which revealed that PAAG-12 films with alpha-tocopherol protected oil-in-water (O/W) emulsions up to 29 days, complying with the Codex Alimentarius. (upc.edu)
  • Since α-tocopherol (AT) is the major antioxidant in LDL, the aim of the present study was to test the effectiveness of RRR-AT supplementation (800 I.U. per day) for 12 weeks on the susceptibility of LDL to oxidation. (elsevier.com)
  • This chain is broken by alpha-tocopherol which is a thousand times more susceptible to reaction with the peroxyl radicals than unsaturated fatty acids. (news-medical.net)
  • Triglycerides containing three saturated fatty acids or three molecules of alpha-linolenic acid have not been reported. (tuscany-diet.net)
  • The fatty acid composition of marula oil includes: Mono-unsaturated fatty acids: Oleic acid (70-78%) Polyunsaturated fatty acids: Linoleic acid (4.0-7.0%) Alpha-linolenic acid (0.1-0.7%) Saturated fatty acids: Palmitic acid (9-12%) Stearic acid (5.0-8.0%) Arachidonic acid (0.3-0.7%) Tocopherols, sterols and flavonoids, with antioxidant action, procyanidin, gallotannin and catechins are also found in marula oil. (wikipedia.org)
  • When more than the daily requirement is administered, there is some storage of tocopherol in the liver (Sebrell & Harris, 1972). (inchem.org)
  • In an elective surgery study in which 22 patients were given 150 mg/d for up to 41 d before surgery, the RRR:rac in tissues was lower than in plasma and the percentage of deuterated alpha-tocopherol was lower in all tissues except gallbladder and liver. (chiro.org)
  • There is practically no urinary excretion of tocopherol but, from studies with labelled material, it appeared that one or more metabolites of tocopherol are excreted in the urine (Sternberg & Pascoe-Dawson, 1959). (inchem.org)
  • Topically applied DL-alpha-tocopherol was substantially absorbed in skin, but the 6-month application did not significantly reduce numbers of preexisting AKs on moderately to severely sun-damaged forearms. (nih.gov)
  • Previous studies have shown that oral administration of 300 mg alpha- tocopherol/day to healthy volunteers decreases platelet function and enhances their sensitivity to the platelet inhibitor, prostaglandin E(1), when full dose-response curves to a range of agonist concentrations are made. (ucl.ac.uk)
  • Although the specific mechanism of action remains unclear, alpha-TOC affords nearly complete protection in vitro from the cellular injury induced by amiodarone. (aspetjournals.org)
  • The immunomodulatory effects of Vitamin E have been demonstrated in vitro, where alpha-tocopherol increases mitogenic response of T lymphocytes from aged mice. (selfdecode.com)
  • Flax seed oil contains linoleic acid and alpha linolenic acid, ALA, an omega-3 fatty acid that can be converted into eicosapentaenoic acid (EPA) in the body. (ovitaminpro.com)
  • Most oxylipins in the body are derived from linoleic acid or alpha-linolenic acid. (wikipedia.org)
  • Linoleic acid oxylipins are usually present in blood and tissue in higher concentrations than any other PUFA oxylipin, despite the fact that alpha-linolenic acid is more readily metabolized to oxylipin. (wikipedia.org)
  • Argan oil contains: 44% Oleic acid 30% Alpha-linolenic acid 12% Palmitic acid 6% Stearidonic acid 5% Linoleic acid(Conflicts with table in argan oil) 3% Myristic acid Argan trees are a major source of forage for sheep, goats, camels and cattle. (wikipedia.org)
  • Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. (nih.gov)
  • We aimed to verify the effects of the concomitant treatment with the antioxidant agent alpha-tocopherol on the motor and cognitive deficits induced by chronic reserpine in rats. (omicsonline.org)
  • Rats were repeatedly treated with 0.1 mg/kg reserpine with or without a concomitant treatment with 40 mg/kg alpha-tocopherol. (omicsonline.org)
  • Because the vitamin activity was first identified in 1936 from a dietary fertility factor in rats, it was given the name "tocopherol" from the Greek words "τόκος" [tókos, birth], and "φέρειν", [phérein, to bear or carry] meaning in sum "to carry a pregnancy," with the ending "-ol" signifying its status as a chemical alcohol. (wikipedia.org)