Alpha synuclein. Medical search

A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.

A family of homologous proteins of low MOLECULAR WEIGHT that are predominately expressed in the BRAIN and that have been implicated in a variety of human diseases. They were originally isolated from CHOLINERGIC FIBERS of TORPEDO.

A homolog of ALPHA-SYNUCLEIN that plays a role in neurofilament network integrity. It is overexpressed in a variety of human NEOPLASMS and may be involved in modulating AXON architecture during EMBRYONIC DEVELOPMENT and in the adult. Gamma-Synuclein may also activate SIGNAL TRANSDUCTION PATHWAYS associated with ETS-DOMAIN PROTEIN ELK-1.

Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.

A synuclein that is closely related to ALPHA-SYNUCLEIN. It may play a neuroprotective role against some of the toxic effects of aggregated ALPHA-SYNUCLEIN.

A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

A PROTEIN O-METHYLTRANSFERASE that recognizes and catalyzes the methyl esterification of ISOASPARTIC ACID and D-ASPARTIC ACID residues in peptides and proteins. It initiates the repair of proteins damaged by the spontaneous decomposition of normal L-aspartic acid and L-asparagine residues.

Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.

A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.

A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.

Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.

An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.

An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.

An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.

An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.

An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.

A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.

This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.

Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.

A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. (1/1546)

alpha-Synuclein is a soluble presynaptic protein which is pathologically redistributed within intracellular lesions characteristic of several neurodegenerative diseases. Here we demonstrate that wild type and two mutant forms of alpha-synuclein linked to familial Parkinson's disease (Ala30 --> Pro and Ala53 --> Thr) self-aggregate and assemble into 10-19-nm-wide filaments with distinct morphologies under defined in vitro conditions. Immunogold labeling demonstrates that the central region of all these filaments are more robustly labeled than the N-terminal or C-terminal regions, suggesting that the latter regions are buried within the filaments. Since in vitro generated alpha-synuclein filaments resemble the major ultrastructural elements of authentic Lewy bodies that are hallmark lesions of Parkinson's disease, we propose that self-aggregating alpha-synuclein is the major subunit protein of these filamentous lesions. (+info)

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. (2/1546)

Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of alpha-synuclein. Two recently identified point mutations in alpha-synuclein are the only known genetic causes of PD, but their pathogenic mechanism is not understood. Here we show that both wild type and mutant alpha-synuclein form insoluble fibrillar aggregates with antiparallel beta-sheet structure upon incubation at physiological temperature in vitro. Importantly, aggregate formation is accelerated by both PD-linked mutations. Under the experimental conditions, the lag time for the formation of precipitable aggregates is about 280 h for the wild type protein, 180 h for the A30P mutant, and only 100 h for the A53T mutant protein. These data suggest that the formation of alpha-synuclein aggregates could be a critical step in PD pathogenesis, which is accelerated by the PD-linked mutations. (+info)

Copper(II)-induced self-oligomerization of alpha-synuclein. (3/1546)

alpha-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was suggested to provide a possible nucleation centre for plaque formation in AD via selective interaction with amyloid beta/A4 protein (Abeta). We have shown previously that alpha-synuclein has experienced self-oligomerization when Abeta25-35 was present in an orientation-specific manner in the sequence. Here we examine this biochemically specific self-oligomerization with the use of various metals. Strikingly, copper(II) was the most effective metal ion affecting alpha-synuclein to form self-oligomers in the presence of coupling reagents such as dicyclohexylcarbodi-imide or N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline. The size distribution of the oligomers indicated that monomeric alpha-synuclein was oligomerized sequentially. The copper-induced oligomerization was shown to be suppressed as the acidic C-terminus of alpha-synuclein was truncated by treatment with endoproteinase Asp-N. In contrast, the Abeta25-35-induced oligomerizations of the intact and truncated forms of alpha-synuclein were not affected. This clearly indicated that the copper-induced oligomerization was dependent on the acidic C-terminal region and that its underlying biochemical mechanism was distinct from that of the Abeta25-35-induced oligomerization. Although the physiological or pathological relevance of the oligomerization remains currently elusive, the common outcome of alpha-synuclein on treatment with copper or Abeta25-35 might be useful in understanding neurodegenerative disorders in molecular terms. In addition, abnormal copper homoeostasis could be considered as one of the risk factors for the development of disorders such as AD or Parkinson's disease. (+info)

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. (4/1546)

Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major components of which are filaments consisting of alpha-synuclein. Two recently identified point mutations in alpha-synuclein are the only known genetic causes of PD. alpha-Synuclein fibrils similar to the Lewy body filaments can be formed in vitro, and we have shown recently that both PD-linked mutations accelerate their formation. This study addresses the mechanism of alpha-synuclein aggregation: we show that (i) it is a nucleation-dependent process that can be seeded by aggregated alpha-synuclein functioning as nuclei, (ii) this fibril growth follows first-order kinetics with respect to alpha-synuclein concentration, and (iii) mutant alpha-synuclein can seed the aggregation of wild type alpha-synuclein, which leads us to predict that the Lewy bodies of familial PD patients with alpha-synuclein mutations will contain both, the mutant and the wild type protein. Finally (iv), we show that wild type and mutant forms of alpha-synuclein do not differ in their critical concentrations. These results suggest that differences in aggregation kinetics of alpha-synucleins cannot be explained by differences in solubility but are due to different nucleation rates. Consequently, alpha-synuclein nucleation may be the rate-limiting step for the formation of Lewy body alpha-synuclein fibrils in Parkinson's disease. (+info)

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. (5/1546)

alpha-Synuclein has been implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease. Mutations in alpha-synuclein cause some cases of familial PD (Polymeropoulos et al., 1997; Kruger et al., 1998). In addition, many neurodegenerative diseases show accumulation of alpha-synuclein in dystrophic neurites and in Lewy bodies (Spillantini et al., 1998). Here, we show that alpha-synuclein shares physical and functional homology with 14-3-3 proteins, which are a family of ubiquitous cytoplasmic chaperones. Regions of alpha-synuclein and 14-3-3 proteins share over 40% homology. In addition, alpha-synuclein binds to 14-3-3 proteins, as well as some proteins known to associate with 14-3-3, including protein kinase C, BAD, and extracellular regulated kinase, but not Raf-1. We also show that overexpression of alpha-synuclein inhibits protein kinase C activity. The association of alpha-synuclein with BAD and inhibition of protein kinase C suggests that increased expression of alpha-synuclein could be harmful. Consistent with this hypothesis, we observed that overexpression of wild-type alpha-synuclein is toxic, and overexpression of alpha-synuclein containing the A53T or A30P mutations exhibits even greater toxicity. The activity and binding profile of alpha-synuclein suggests that it might act as a protein chaperone and that accumulation of alpha-synuclein could contribute to cell death in neurodegenerative diseases. (+info)

Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. (6/1546)

Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases. They are characterized by the degeneration of selected populations of nerve cells that develop filamentous inclusions before degeneration. The neuronal inclusions of Alzheimer's disease are made of the microtubule-associated protein tau, in a hyperphosphorylated state. Recent work has shown that the filamentous inclusions of Parkinson's disease are made of the protein alpha-synuclein and that rare, familial forms of Parkinson's disease are caused by missense mutations in the alpha-synuclein gene. Besides Parkinson's disease, the filamentous inclusions of two additional neurodegenerative diseases, namely dementia with Lewy bodies and multiple system atrophy, have also been found to be made of alpha-synuclein. Abundant filamentous tau inclusions are not limited to Alzheimer's disease. They are the defining neuropathological characteristic of frontotemporal dementias such as Pick's disease, and of progressive supranuclear palsy and corticobasal degeneration. The recent discovery of mutations in the tau gene in familial forms of frontotemporal dementia has provided a direct link between tau dysfunction and dementing disease. The new work has established that tauopathies and alpha-synucleinopathies account for most late-onset neurodegenerative diseases in man. The formation of intracellular filamentous inclusions might be the gain of toxic function that leads to the demise of affected brain cells. (+info)

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. (7/1546)

alpha-Synuclein has been implicated in the pathogenesis of several neurodegenerative disorders based on the direct linking of missense mutations in alpha-synuclein to autosomal dominant Parkinson's disease and its presence in Lewy-like lesions. To gain insight into alpha-synuclein functions, we have investigated whether it binds neuronal proteins and modulates their functional state. The microtubule-associated protein tau was identified as a ligand by alpha-synuclein affinity chromatography of human brain cytosol. Direct binding assays using (125)I-labeled human tau40 demonstrated a reversible binding with a IC(50) about 50 pM. The interacting domains were localized to the C terminus of alpha-synuclein and the microtubule binding region of tau as determined by protein fragmentation and the use of recombinant peptides. High concentrations of tubulin inhibited the binding between tau and alpha-synuclein. Functionally, alpha-synuclein stimulated the protein kinase A-catalyzed phosphorylation of tau serine residues 262 and 356 as determined using a phospho-epitope-specific antibody. We propose that alpha-synuclein modulates the phosphorylation of soluble axonal tau and thereby indirectly affects the stability of axonal microtubules. (+info)

The genetics of disorders with synuclein pathology and parkinsonism. (8/1546)

Despite being considered the archetypal non-genetic neurological disorder, genetic analysis of Parkinson's disease has shown that there are at least three genetic loci. Furthermore, these analyses have suggested that the phenotype of the pathogenic loci is wider than simple Parkinson's disease and may include Lewy body dementia and some forms of essential tremor. Identification of alpha-synuclein as the first of the loci involved in Parkinson's disease and the identification of this protein in pathological deposits in other disorders has led to the suggestion that it may share pathogenic mechanisms with multiple system atrophy, Alzheimer's disease and prion disease and that these mechanisms are related to a synuclein pathway to cell death. Finally, genetic analysis of the synuclein diseases and the tau diseases may indicate that this synuclein pathway is an alternative to the tau pathway to cell death. (+info)

Therefore, NACP is now referred to as human alpha-synuclein. Alpha-synuclein is a synuclein protein of unknown function ... which contain rich cytosolic alpha-synuclein but very low levels of mitochondrial alpha-synuclein. It has been shown that alpha ... Alpha-synuclein is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates ... The human alpha-synuclein protein is made of 140 amino acids. An alpha-synuclein fragment, known as the non-Abeta component ( ...

https://en.wikipedia.org/wiki/Alpha-synuclein

... alpha-synuclein, beta-synuclein, and gamma-synuclein. Interest in the synuclein family began when alpha-synuclein was found to ... Alpha-synuclein InterPro: IPR002460 Beta-synuclein InterPro: IPR002461 Gamma-synuclein InterPro: IPR002462 Normal cellular ... All synucleins have in common a highly conserved alpha-helical lipid-binding motif with similarity to the class-A2 lipid- ... Mutations in alpha-synuclein are associated with early-onset familial Parkinson's disease and the protein aggregates abnormally ...

https://en.wikipedia.org/wiki/Synuclein

Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (August 1997). "Alpha-synuclein in Lewy bodies". Nature ... alpha-synuclein was discovered to be the major component of Lewy bodies within brain cells of PD patients; according to the ... alpha-synuclein. Lazzarini worked with the Italian Instituto de Scienze Neurologiche to get blood samples from the family ... that fragments of alpha-synuclein bind to other proteins to form the Lewy body, an insoluble proteinaceous material ...

https://en.wikipedia.org/wiki/Alice_Lazzarini

The NIH team and a team led by Maria Grazia Spillantini reported on alpha-synuclein deposits in Lewy bodies as well as alpha- ... Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (1997). "Alpha-synuclein in Lewy bodies". Nature. 388 ( ... Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998). "Alpha synuclein in neurodegenerative disorders ... 1997). "Mutation in the alpha-synuclein gene identified in families with Parkinson's disease". Science. 276 (5321): 2045-7. doi ...

https://en.wikipedia.org/wiki/Contursi_Terme

Alpha-synuclein modulates DNA repair processes, including repair of DNA double-strand breaks (DSBs) by the process of non- ... July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". ... Cortical Lewy bodies are also composed of alpha-synuclein fibrils, but are less defined and lack halos. This kind of Lewy body ... Ishizawa T, Mattila P, Davies P, Wang D, Dickson DW (April 2003). "Colocalization of tau and alpha-synuclein epitopes in Lewy ...

https://en.wikipedia.org/wiki/Lewy_body

... alpha-synuclein. Within days of the publication of the PARK1 findings, alpha-synuclein was discovered to be the major component ... Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M (August 1997). "Alpha-synuclein in Lewy bodies". Nature ... Schulz-Schaeffer WJ (August 2010). "The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, ... "Mutation in the alpha-synuclein gene identified in families with Parkinson's disease". Science. 276 (5321): 2045-7. doi:10.1126 ...

https://en.wikipedia.org/wiki/History_of_Parkinson's_disease

She is most noted for identifying the protein alpha-synuclein as the major component of Lewy bodies, the characteristic protein ... In particular her work studies the role of microtubule-associated protein tau and alpha-synuclein aggregation in the ... "Alpha-synuclein in Lewy bodies". Nature. 388 (6645): 839-40. Bibcode:1997Natur.388..839G. doi:10.1038/42166. PMID 9278044. ...

https://en.wikipedia.org/wiki/Maria_Grazia_Spillantini

The conformation of the alpha-synuclein is different from that of alpha-synuclein in Lewy bodies. The disease probably starts ... A modified form of the alpha-synuclein protein within affected neurons may cause MSA. About 55% of MSA cases occur in men, with ... November 1998). "NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic ... September 2009). "Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy". PLOS ONE. 4 ( ...

https://en.wikipedia.org/wiki/Multiple_system_atrophy

Preclinical research also targets alpha-synuclein. Selegiline is in a group of medications called monoamine oxidase type B (MAO ...

https://en.wikipedia.org/wiki/Management_of_Parkinson's_disease

It shows a 60-times magnification of the alpha synuclein intraneuronal inclusions aggregated to form Lewy bodies. Stains used: ... mouse monoclonal alpha-synuclein antibody; counterstained with Mayer's haematoxylin., retrieved 2021-12-10 v t e (Cell biology ...

https://en.wikipedia.org/wiki/I-cell

Moussaud S, Jones DR, Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ (October 2014). "Alpha-synuclein and tau: ... Tauopathies are often overlapped with synucleinopathies, possibly due to interaction between the synuclein and tau proteins. ...

https://en.wikipedia.org/wiki/Tauopathy

Alpha-synuclein modulates DNA repair processes, including the repair of DNA double-strand breaks by the non-homologous end ... Alpha-synuclein deposits can affect the cardiac muscle and blood vessels. Almost all people with synucleinopathies have ... The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may ... October 2014). "Alpha-synuclein and tau: teammates in neurodegeneration?". Mol Neurodegener. 9: 43. doi:10.1186/1750-1326-9-43 ...

https://en.wikipedia.org/wiki/Synucleinopathy

Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E (March 2008). "alpha-Synuclein ... Parkin might promote aggregation of alpha-synuclein and synphilin-1 into Lewy bodies, which are conjugated to Lys63-linked poly ... Another parkin substrate, synphilin-1 (encoded by SNCAIP), is an alpha-synuclein interacting protein that is enriched in the ... Parkin (ligase) has been shown to interact with: Alpha-synuclein, CASK, CUL1, FBXW7 and GPR37, HSPA1A, HSPA8, Multisynthetase ...

https://en.wikipedia.org/wiki/Parkin_(protein)

October 2003). "alpha-Synuclein locus triplication causes Parkinson's disease". Science. 302 (5646): 841. doi:10.1126/science. ... One example of a whole gene repeat is the alpha-amylase 1 gene (AMY1) that encodes alpha-amylase which has a significant copy ... The globin gene family is an elaborate network of genes consisting of alpha and beta globin genes including genes that are ... and one type of amylase is encoded by the alpha-amylase gene (AMY1). The AMY1 locus, as well as the amylase enzyme, is one of ...

https://en.wikipedia.org/wiki/Copy_number_variation

Alpha-synuclein is the primary structural component of Lewy body fibrils. In addition, an alpha-synuclein fragment, known as ... it is alpha-synuclein. In Huntington's disease, it is huntingtin. Transglutaminase substrates: Amyloid-beta, tau, alpha- ... Membrane damage by alpha-synuclein could be another Parkinson's disease mechanism. The main known risk factor is age. Mutations ... Notably, alpha-synuclein-ubiquitin complexes and aggregates are observed to accumulate in Lewy bodies within affected neurons. ...

https://en.wikipedia.org/wiki/Neurodegenerative_disease

2006). "Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression". Hum. Mol. Genet ... 2005). "beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein". J. Biol. Chem. 280 (9): 7562 ... 1997). "Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind ... Thus, beta-synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel ...

https://en.wikipedia.org/wiki/Beta-synuclein

... stands for "synuclein, alpha interacting protein" and can be signified by SNCAP_HUMAN, synphilin 1, synuclein, alpha ... "Entrez Gene: SNCAIP synuclein, alpha interacting protein (synphilin)". Neystat M, Rzhetskaya M, Kholodilov N, Burke RE (June ... Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian MM (2004). "Aggresomes formed by alpha-synuclein and synphilin-1 are ... The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic ...

https://en.wikipedia.org/wiki/SNCAIP

Lee FJ, Liu F, Pristupa ZB, Niznik HB (April 2001). "Direct binding and functional coupling of alpha-synuclein to the dopamine ... Dopamine transporter has been shown to interact with: Alpha-synuclein, PICK1, and TGFB1I1. Apart from these innate protein- ... Wersinger C, Sidhu A (April 2003). "Attenuation of dopamine transporter activity by alpha-synuclein". Neuroscience Letters. 340 ...

https://en.wikipedia.org/wiki/Dopamine_transporter

"Glycosylation as an Inhibitor of Alpha-synuclein Aggregation". The Michael J. Fox Foundation for Parkinson's Research , ... As O-GlcNAc modification of α-synuclein has been found to inhibit its aggregation, elevating α-synuclein O-GlcNAc is being ... Solid-phase peptide synthesis was used to prepare full-length α-synuclein with an O-GlcNAc modification at T72. Thioflavin T ... For example, a nanobody recognizing a C-terminal EPEA sequence can direct OGT enzymatic activity to α-synuclein. Apoptosis, a ...

https://en.wikipedia.org/wiki/O-GlcNAc

Chandra S, Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC (November 2005). "Alpha-synuclein cooperates with CSPalpha in ... 2005). "Characterization of the G alpha(s) regulator cysteine string protein". J. Biol. Chem. 280 (34): 30236-41. doi:10.1074/ ... "The synaptic vesicle protein CSP alpha prevents presynaptic degeneration". Neuron. 42 (2): 237-51. doi:10.1016/S0896-6273(04) ... encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis". American Journal ...

https://en.wikipedia.org/wiki/DNAJC5

2002). "Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly ... Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of ... Gamma-synuclein is the least conserved of the synuclein proteins. Gamma-Synucleins expression in breast tumors is a marker for ... 2003). "Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects". J. Alzheimer's Dis. 4 (4): ...

https://en.wikipedia.org/wiki/Gamma-synuclein

"Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". The Journal of Biological Chemistry. 275 ( ... Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000). "Synucleins are a novel class of substrates for G protein-coupled ... Zhou H, Yan F, Tai HH (Sep 2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein- ...

https://en.wikipedia.org/wiki/GRK5

December 2017). "Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes". The Journal of Neuroscience. 37 ... Also, FABP proteins have recently been shown to interact with a protein called synuclein to cause mitochondrial damage. ... Cheng, A (2021). "Impact of fatty acid-binding proteins in α-Synuclein-induced mitochondrial injury in synucleinopathy". ...

https://en.wikipedia.org/wiki/Astrocyte

Alpha-synuclein from Multiple system atrophy and TMEM106B. Scheres has been a member of the Board of Reviewing Editors for ... "Structures of alpha-synuclein filaments from multiple system atrophy". Nature. 585: 464-469. doi:10.1038/s41586-020-2317-6. PMC ...

https://en.wikipedia.org/wiki/Sjors_Scheres

... and Lewy bodies and neurites were found to be immunoreactive for alpha-synuclein. Thus, alpha-synuclein aggregation as the ... and reducing amyloid beta or alpha-synuclein accumulation. Therapies under study as of 2019 aim to reduce brain levels of alpha ... The role of alpha-synuclein deposits is unclear, because individuals with no signs of DLB have been found on autopsy to have ... Rarely, mutations in SNCA, the gene for alpha-synuclein, or LRRK2, a gene for a kinase enzyme, can cause any of DLB, ...

https://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies

The Road to Alpha-Synuclein Oligomerization in PD". Parkinson's Disease. 2011: 693761. doi:10.4061/2011/693761. PMC 3026982. ... Mutations of synuclein alleles lead to lysosome pH increase and hydrolase inhibition. As a result, lysosomes degradative ... Parkinson's disease is characterized by inclusions of a protein called alpha-synuclien (Lewy bodies) in affected neurons that ...

https://en.wikipedia.org/wiki/Autophagy

... overexpression in human neuroglioma cells transfected with mutant alpha-synuclein led to 50% less oligomeric alpha- ... April 2008). "Formation of toxic oligomeric alpha-synuclein species in living cells". PLOS ONE. 3 (4): e1867. Bibcode:2008PLoSO ... In breast cancer cell line (MCF7) has been found that not only Hsp90 interacted with estrogen receptor alpha (ERα) but also ... C-terminal domain - rich in alpha helical structure acts as a 'lid' for the substrate binding domain. The helical subdomain ...

https://en.wikipedia.org/wiki/Hsp70

"Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications". Ann Neurol. 55 (2): 174-9. doi:10.1002/ ...

https://en.wikipedia.org/wiki/William_Langston

"Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy". Science. 305 (5688): 1292-5. doi:10.1126/ ...

https://en.wikipedia.org/wiki/Ana_Maria_Cuervo

It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein ... and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein ... RA receptor alpha in acute promyelocytic leukemia cells". The Journal of Biological Chemistry. 276 (25): 22375-81. doi:10.1074/ ... alpha and directs integrin-activated cytoskeletal reorganization in macrophages. GRCh38: Ensembl release 89: ENSG00000005020 - ...

https://en.wikipedia.org/wiki/SKAP2

... alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration. John ... "Biology of Synuclein and Cortical Lewy Bodies Associated with Dementia in AD, LBD, and PD" (July, 2001) and "Genetics of ...

https://en.wikipedia.org/wiki/John_Q._Trojanowski

"Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis". Molecular and Cellular Biochemistry ... "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". The EMBO Journal. 32 (23): 3041-54. doi:10.1038/ ...

https://en.wikipedia.org/wiki/ENDOG

... including alpha-synuclein, Tau and several N-terminal fragments of the Huntingtin protein. In addition, in collaboration with ... and alpha-synuclein-mediated toxicity and showed that inhibiting fibril growth and seeding capacity using small molecules ... Research in the Lashuel group has led to the discovery of novel kinases that regulate alpha-synuclein and Huntingtin ... to elucidate their role in alpha-synuclein-induced toxicity and potential contributions to the pathogenesis of Parkison's ...

https://en.wikipedia.org/wiki/Hilal_Lashuel

Her research has also shown how alpha-synuclein protein builds up in neurons that connect cells in Dementia with Lewy Bodies, ...

https://en.wikipedia.org/wiki/Tara_Spires-Jones

Similarly the protein alpha-synuclein is hypothesized to accumulate in Parkinson's and related diseases. Treatments with ...

https://en.wikipedia.org/wiki/Neuroscience_of_aging

Critical Challenges in 2009/2010 include: speeding research on PD genetic targets, LRRK2 and alpha-synuclein; advancing ...

https://en.wikipedia.org/wiki/The_Michael_J._Fox_Foundation

Vorinostat In an alpha-synuclein overexpressing Drosophila model of PD, vorinostat (as well as sodium butyrate) reduced alpha- ... miR-7 and miR-153 act to reduce alpha-synuclein levels (a hallmark of PD) but are reduced in PD brain. DNA methylation Neurons ... Histone marks alpha-synuclein, the protein encoded by SNCA, can associate with histones and prevent their acetylation in ... Hallmarks include mutations to the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and ...

https://en.wikipedia.org/wiki/Epigenetics_of_neurodegenerative_diseases

Parkinson's disease could be due to an interference with a chaperone-mediated autophagy caused by the protein alpha-synuclein. ... Cuervo, A. M.; Stefanis, L.; Fredenburg, R.; Lansbury, P.; Sulzer, D. (2004). "Impaired Degradation of Mutant -Synuclein by ... "Dopamine-modified α-synuclein blocks chaperone-mediated autophagy". Journal of Clinical Investigation. 118 (2): 777-788. doi: ...

https://en.wikipedia.org/wiki/David_Sulzer

Li W, Lee MK (June 2005). "Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the ...

https://en.wikipedia.org/wiki/Neuroprotection

2002). "alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling ...

https://en.wikipedia.org/wiki/MAPK8IP1

Arima K, Uéda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M (November 1998). "NACP/alpha-synuclein ... It has been shown that cuminaldehyde, as a small molecule, inhibits the fibrillation of alpha-synuclein, which, if aggregated, ... a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity". Journal of Food Science. 80 (10): ... "Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in ...

https://en.wikipedia.org/wiki/Cuminaldehyde

Olanow CW, Brundin P (January 2013). "Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder?". ... was caused by a prion form of alpha-synuclein. Prions are a type of intrinsically disordered protein, which change their ... the misfolded form of a protein called alpha-synuclein. The endogenous, properly folded form of the prion protein is denoted ... Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein". Science. 349 (6248 ...

https://en.wikipedia.org/wiki/Prion

The role of the SNCA gene is significant in PD because the alpha-synuclein protein is the main component of Lewy bodies, which ... Level of alpha-synuclein expression correlates with disease onset and progression, with SNCA gene triplication advancing ... PARK11 and GIGYF2 and PARK13 which code for alpha-synuclein (SNCA), UCHL1, leucine-rich repeat kinase 2 (LRRK2 or dardarin) ( ... and loss-of-function GBA mutations are proposed to contribute to parkinsonism through effects such as increased alpha-synuclein ...

https://en.wikipedia.org/wiki/Causes_of_Parkinson's_disease

For example, in patients with Parkinson's disease, levels of Natural killer cells are elevated as they degrade alpha-synuclein ...

https://en.wikipedia.org/wiki/Natural_killer_cell

They also discovered a type of chaperone protein can reduce the death of neurons caused by alpha-synuclein built-up, and that ... In 2004, they associated alpha-synuclein in the brain with multiple system atrophy. Two years later, they showed for the first ... For Parkinson's disease, Lee and Trojanowski reported that another protein, alpha-synuclein, is a major component of Lewy ... healthy neurons may take up extracellular alpha-synuclein and become defective in function. Apart from these two relatively ...

https://en.wikipedia.org/wiki/Virginia_Man-Yee_Lee

"DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation". PLOS Biology. 2 (11): e362. ... "The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein". Journal of Molecular Biology. 356 (4): ... Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus ... "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". The Journal of ...

https://en.wikipedia.org/wiki/PARK7

RBD associated with neurological disorders is frequently related to abnormal accumulation of alpha-synuclein, and more than 80 ...

https://en.wikipedia.org/wiki/Parasomnia

... and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89-94. doi:10.1007/s00439-008-0525-5. PMID 18568448 ...

https://en.wikipedia.org/wiki/2,4-dienoyl-CoA_reductase_1

"Nitration and increased alpha-synuclein expression associated with dopaminergic neurodegeneration in equine pituitary pars ...

https://en.wikipedia.org/wiki/Pituitary_pars_intermedia_dysfunction

Some pathological proteins, such as alpha-synuclein, cannot be degraded and cause the aggresomes to form inclusion bodies (in ...

https://en.wikipedia.org/wiki/Aggresome

... alpha-synuclein residues 47-56". doi:10.2210/pdb4znn/pdb. {{cite journal}}: Cite journal requires ,journal= (help) Liu, S.; ...

https://en.wikipedia.org/wiki/Microcrystal_electron_diffraction

... in alpha-synuclein (α-Syn) aggregation and misfolding, a characteristic of Parkinson's disease pathology. If there is a balance ... and tumor necrosis factor alpha (TNF-α), which can induce neuronal cytotoxicity. Although the pro-inflammatory cytokines may ...

https://en.wikipedia.org/wiki/Neuroinflammation

All posts tagged with alpha-synuclein. * This neuron-killing protein travels from the gut to the brain by hijacking a nerve. ... Natural News) A recent study published in the journal Neuron found that alpha-synuclein (a-syn), a protein genetically linked ... According to researchers from Aarhus University in Denmark, disease-causing proteins called alpha-synuclein travel up to the ...

https://www.naturalnews.com/tag/alpha-synuclein/

Aggregated alpha-synuclein can be detected by anti-alpha synuclein filament antibody (ab209530), which is a conformation- ... misfolding and aggregation of native alpha-synuclein occurs, resulting in the formation of filamentous Lewy bodies. ... Aggregated alpha-synuclein can be detected by anti-alpha synuclein filament antibody (ab209530), which is a conformation- ... Anti-alpha synuclein filament antibody [MJFR14-6-4-2] (ab209538):. *Developed with experts in the field - Developed and tested ...

https://www.news-medical.net/whitepaper/20180124/Conformation-Specific-Alpha-Synuclein-Antibody-for-Parkinsons-Disease.aspx

Aggregation of alpha-synuclein (SNCA) may underlie the pathology of PD. They are the main components of Lewy bodies and ... Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinsons Disease Neurochem Res. ... Aggregation of alpha-synuclein (SNCA) may underlie the pathology of PD. They are the main components of Lewy bodies and ...

https://pubmed.ncbi.nlm.nih.gov/27364962/

Knockout Tested Rabbit recombinant monoclonal Alpha-synuclein antibody [MJFR1]. Validated in WB, IP, IHC, ICC/IF, Flow Cyt ( ... Alexa Fluor® 488 Anti-Alpha-synuclein antibody [MJFR1] (ab195025) *Anti-Alpha-synuclein antibody [MJFR1] - BSA and Azide free ( ... All lanes : Anti-Alpha-synuclein antibody [MJFR1] (ab138501) at 1/10000 dilution. Lane 1 : Wild-type HEK-293T cell lysate. Lane ... All lanes : Anti-Alpha-synuclein antibody [MJFR1] (ab138501) at 1/10000 dilution. Lane 1 : Wild-type HAP1 whole cell lysate. ...

https://www.abcam.com/alpha-synuclein-antibody-mjfr1-ab138501.html

Anti-α-Synuclein, 80-96: 2.0 - 10.0 µg/ml. Anti-α-Synuclein (C-Terminal Truncated x-122): 2.0 - 10.0 µg/ml. Anti-α-Synuclein ... Lane 1: 50 ng of recombinant human α-synuclein; Lane 2: 50 ng of recombinant human pS87 α-synuclein; Lane 3: 25 µg of normal ... Lane 1: 50 ng of recombinant human α-synuclein; Lane 2: 50 ng of recombinant C-terminally truncated human α-synuclein (1-122). ... IHC staining of α-synuclein deposits with purified anti-α-Synuclein, C-Terminal Truncated antibody (clone A15127A) on formalin- ...

https://www.biolegend.com/ja-jp/products/alpha-synuclein-antibody-sampler-kit-15846

... kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double ... Murphy, D. D., Rueter, S. M., Trojanowski, J. Q. & Lee, V. M. Synucleins are developmentally expressed, and alpha-synuclein ... Zarranz, J. J. et al. The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann. Neurol. 55, 164- ... Chaprov, K. D. et al. Increased expression of the multimerin-1 gene in alpha-synuclein knockout mice. Dokl. Biol. Sci. 494, 260 ...

https://www.nature.com/articles/s41598-022-13557-8?error=cookies_not_supported&code=0f5b0737-812c-4047-b2ae-53a75c33f4c2

Alpha-synuclein Seed Amplification Assay RFA ...

https://share.vidyard.com/watch/QWsUKJ3u64s1DTEDYHQufz

NMR structure of the complex of an N-terminally acetylated alpha-synuclein peptide with calmodulin ... Alpha-synuclein. B. 21. Homo sapiens. Mutation(s): 2 Gene Names: SNCA, NACP, PARK1. ... NMR Structure of Calmodulin Complexed to an N-Terminally Acetylated alpha-Synuclein Peptide.. Gruschus, J.M., Yap, T.L., ... NMR structure of the complex of an N-terminally acetylated alpha-synuclein peptide with calmodulin. *PDB DOI: 10.2210/pdb2M55/ ...

https://www.rcsb.org/structure/2M55

The formation of large alpha-synuclein protein inclusions in the brain is the pathological hallmark of Parkinsons disease but ... We also discovered that some of the modifiers altered the intracellular distribution pattern of alpha-synuclein, and we are now ... The formation of large alpha-synuclein protein inclusions in the brain is the pathological hallmark of Parkinsons disease but ... Deciphering the Molecular Effects of Alpha-Synuclein in the Nucleus: DNA Binding and Transcriptional Dysregulation ...

https://www.michaeljfox.org/grant/unraveling-genetic-basis-alpha-synuclein-oligomerization-living-cells-using-bimolecular-0

The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, ... Cryo-EM structure of alpha-synuclein fibril.. Details of the cryo-EM reconstruction of an alpha-synuclein fibril at 3.4 Å ...

https://elifesciences.org/articles/36402/figures

Here, we investigated the link between PD-related mutant alpha-Synuclein (alpha-SYN) pathology and olfactory deficit, by ... Neuner, Johanna; Filser, Severin; Michalakis, Stylianos; Biel, Martin; Herms, Jochen (2014): A30P alpha-Synuclein interferes ... Using in vivo two-photon imaging, we followed the dynamic process of neuronal turnover in transgenic A30P alpha-SYN and wild- ... examining the integration of adult-born neurons in the olfactory bulb (OB) of A30P alpha-SYN overexpressing mice. To this end, ...

https://epub.ub.uni-muenchen.de/33767/

Ken Griffin Alpha-synuclein Imaging Competition, a program to spur a scientific race in pursuit of an imaging tracer to ... visualize the key protein alpha-synuclein in the living brains of people with Parkinsons disease. ... And researchers developing therapies to target alpha-synuclein will be able to see how well their drug is working. An alpha- ... Ken Griffin Alpha-synuclein Imaging Competition Winners Announced. Jul 31, 2020 , Parkinsons Disease, Research & Development ...

https://ptproductsonline.com/neurological/parkinsons/ken-griffin-alpha-synuclein-imaging-competition-winners-announced/

Human alpha Synuclein protein (active, Pre-Formed Fibrils) validated in Functional Assay, and available in 200 μg, 100 μg ... Endogenous alpha-synuclein phosphorylation. 100 μM alpha synuclein protein monomer (GTX17668-pro) seeded with 10 nM alpha ... Active alpha synuclein preformed fibrils (GTX17669-pro) seed the formation of new alpha synuclein fibrils from the pool of ... correlated to alpha synuclein protein aggregation) over time when 10 nM of active alpha synuclein preformed fibrils (GTX17669- ...

https://www.genetex.com/Product/Detail/Human-alpha-Synuclein-protein-active-Pre-Formed-Fibrils/GTX17669-pro

alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. Useful for ... This antibody recognizes the alpha-synuclein containing the A30P and A53T mutations. Excellent for western blotting, ... α-synuclein is a member of the synuclein protein family, the other two members being β and γ synuclein, each protein being ... Point mutations of α-synuclein proved to be causative of some forms of familial Parkinsons disease. α-synuclein is also found ...

https://www.neuromics.com/CH22139

Alpha Synuclein Elisa Kit For Mouse. Lab Reagents Human IgG antibody Laboratories manufactures the alpha synuclein elisa kit ... please contact Synuclein elisa. Other Alpha products are available in stock. Specificity: Alpha Category: Synuclein Group: ... The Alpha Synuclein Elisa Kit For Mouse reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To ... The antigen used for immunization is Human alpha synuclein monomer. The antibody is tested and validated for WB, DB, ICC/IF, ...

https://www.aabioetica.org/alpha-synuclein-elisa-kit-for-mouse/

Re-imagining discovery and access to research: grants, datasets, publications, citations, clinical trials, patents and policy documents in one place.

https://app.dimensions.ai/details/publication/pub.1050561120

Alpha-Syn is widely expressed in the brain. There is increasing evidence that misfolded aggregated Alpha-Syn is the causative ... Neurodegenerative diseases characterised by aggregates of the protein Alpha-Synuclein are referred to by the umbrella term ... Neurodegenerative diseases characterised by aggregates of the protein Alpha-Synuclein are referred to by the umbrella term ... Alpha-Syn is widely expressed in the brain. There is increasing evidence that misfolded aggregated Alpha-Syn is the causative ...

https://www.medillsb.com/illustration_image_details.aspx?AID=13500&IID=259246

Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family. ... Gene, Mutation, Parkinsonism, SNCA, Triplication, α-synuclein Persistent URL doi.org/10.1016/j.parkreldis.2015.06.005, hdl. ... Early-onset parkinsonism caused by alpha-synuclein gene triplication: Clinical and genetic findings in a novel family. ... Introduction: Triplications of SNCA, the gene encoding for α-synuclein, cause a very rare Mendelian form of early-onset ...

https://repub.eur.nl/pub/86202

MDS funded workshop: Alpha synuclein: The Gateway to Parkinsonism. *Roger Barker (Speaker) ...

https://portal.research.lu.se/en/activities/mds-funded-workshop-alpha-synuclein-the-gateway-to-parkinsonism

Alpha-Synuclein Autophagy Parkinsons disease Protein conformation ACTIVE-SITE CELL KYP-2047 PROTEIN BRAIN ENDOPEPTIDASE ... negatively regulates autophagy and increases the aggregation of alpha-synuclein (alpha Syn), linking it to the pathophysiology ... The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their ... The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their ...

https://helda.helsinki.fi/handle/10138/319279

In PD, the sticky protein is alpha-synuclein, forming Lewy bodies. Here is a thorough review of alpha-synucleins role in ... alpha-synuclein. The blue spot: where seeds of destruction begin. Neuroscientist and geneticist David Weinshenker makes a case ... The protein alpha-synuclein is a bad actor in PD (nice explainer from Michael J. Fox Foundation); its a major constituent of ... Alpha-synuclein is a major component of Lewy bodies, the protein clumps that are a pathological sign of PD. Also, duplications ...

https://www.emoryhealthsciblog.com/tag/alpha-synuclein/

... Author: Lerche, Stefanie; Schulte, ... The Mutation Matters: CSF Profiles of GCase, Sphingolipids, alpha-Synuclein in PDGBA. DSpace Repository. Login ...

https://publikationen.uni-tuebingen.de/xmlui/handle/10900/131117

Lee JT, Wheeler TC, Li L and Chin LS (2008) Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation ... Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. ... Bartels T, Kim NC, Luth ES and Selkoe DJ (2014) N-alpha-acetylation of alpha-synuclein increases its helical folding propensity ... protein kinase 1 phosphorylates alpha-synuclein at Ser129 and exacerbates rotenone-induced toxic aggregation of alpha-synuclein ...

https://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2022.55.7.073

... triplications and point mutations in the alpha-synuclein gene are associated with familial forms of PD makes alpha-synuclein an ... As part of this work we have now discovered that the first steps of alpha-synuclein aggregation follow significantly different ... Modulating the aggregation of alpha-synuclein and prion protein with small molecules.. by Luis Eduardo Fonseca Ornelas ... We further demonstrated that the aggregation of vesicle-bound alpha-synuclein depends on the insertion of the hydrophobic ...

https://ediss.uni-goettingen.de/handle/11858/00-1735-0000-002B-7C8F-3?locale-attribute=en

Amelioration of Alpha-Synuclein in Parkinsons Disease through potentiated protein-protein interactions. By Jeremiah Pate ... Amelioration of Alpha-Synuclein in Parkinsons Disease through potentiated protein-protein interactions Pate, Jeremiah.. , 13 ... Aggregation of misfolded alpha synuclein protein is a key feature of Parkinsons Disease (PD), which afflicts 53 million ... It will also demonstrate the novel use of the small chaperone molecular switch to enhance alpha synuclein selectivity. We plan ...

https://experiment.com/projects/amelioration-of-alpha-synuclein-in-parkinson-s-disease-through-potentiated-protein-protein-interactions

... patient genomes could modulate alpha-synuclein (aSYN) protein aggregates formation. We found increased β-sheets and aggregated ... The intracellular milieu of Parkinsons disease patient brain cells modulates alpha-synuclein protein aggregation. Alzforum ... The intracellular milieu of Parkinsons disease patient brain cells modulates alpha-synuclein protein aggregation. Access & ...

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01256-w/metrics

REST Protects Dopaminergic Neurons from Mitochondrial and a-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing ... REST Protects Dopaminergic Neurons from Mitochondrial and a-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing ... A story about how α-synuclein changes the comings and goings of dopamine * Threlfell et al 2021 Glossary ...

https://www.dpag.ox.ac.uk/publications/1196779

Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2022 Elsevier B.V We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...

https://augusta.pure.elsevier.com/en/projects/functions-of-alpha-synuclein-in-neurotransmitter-release

Trexler AJ, Rhoades E: N-Terminal acetylation is critical for forming alpha-helical oligomer of alpha-synuclein. Protein Sci. ... Ulmer TS, Bax A, Cole NB, Nussbaum RL: Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem. 2005 Mar 11; ... Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: alpha-Synuclein is ... Proukakis C, Dudzik CG, Brier T, MacKay DS, Cooper JM, Millhauser GL, Houlden H, Schapira AH: A novel alpha-synuclein missense ...

http://www.t3db.ca/biodb/polypeptides/P37840

The major component of these Lewy Bodies is a protein called alpha-synuclein. Alpha-syn is a 14kDa protein made of 140 amino ... This makes alpha-syn a good biomarker for both diagnosis and potential treatment. However, being able to quickly identify alpha ... It has been shown in various studies that targeting alpha-syn can slow down or mitigate the effects of PD. It has also been ... In this experiment, I use antibodies, 1H5 and 2A4, to quickly identify relative amounts of alpha-syn in human PD blood plasma. ...

https://digitalcommons.usf.edu/etd/9317/

Aggregation of alpha-synuclein (SNCA) may underlie the pathology of PD. (nih.gov)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Synuclein Alpha (SNCa) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (aabioetica.org)
Introduction: Triplications of SNCA, the gene encoding for α-synuclein, cause a very rare Mendelian form of early-onset parkinsonism combined with cognitive and autonomic dysfunctions. (eur.nl)
Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein ( IC 50 =1.5 μM). (medchemexpress.com)
Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. (medchemexpress.com)
The SNCA gene provides instructions for making a small protein called alpha-synuclein. (medlineplus.gov)
In dementia with Lewy bodies, SNCA gene mutations lead to the production of an alpha-synuclein protein with an abnormal shape. (medlineplus.gov)
The extra copies of the SNCA gene lead to an excess of alpha-synuclein protein. (medlineplus.gov)
Nonetheless, some areas with alpha-synuclein buildup were not associated with those pathways, but instead to higher levels of SNCA , the gene that provides instructions for alpha-synuclein. (parkinsonsnewstoday.com)
There is increasing evidence for the contribution of synuclein alpha ( SNCA ) to the etiology of neurological disorders, such as Parkinson's disease (PD). (mdpi.com)

Natural News) A recent study published in the journal Neuron found that alpha-synuclein (a-syn), a protein genetically linked to Parkinson's disease, spreads from the gut to the brain through the vagus nerve. (naturalnews.com)
In the brains of patients suffering from Parkinson's disease, misfolding and aggregation of native alpha-synuclein occurs, resulting in the formation of filamentous Lewy bodies. (news-medical.net)
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. (abcam.com)
IHC staining of α-synuclein deposits with purified anti-α-Synuclein, C-Terminal Truncated antibody (clone A15127A) on formalin-fixed, paraffin-embedded Parkinson's disease brain tissue. (biolegend.com)
We recently became interested in the potential role of Rab27s in Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB), two neurodegenerative disorders that are marked by pathological cytoplasmic aggregates, termed Lewy Bodies, which are highly enriched in alpha-synuclein (αsyn) 30 . (nature.com)
The formation of large alpha-synuclein protein inclusions in the brain is the pathological hallmark of Parkinson's disease but whether those inclusions are the actual culprits remains unknown. (michaeljfox.org)
The Michael J. Fox Foundation for Parkinson's Research (MJFF) has announced the winners of the "Ken Griffin Alpha-synuclein Imaging Competition," a program to spur a scientific race in pursuit of an imaging tracer to visualize the key protein alpha-synuclein in the living brains of people with Parkinson's disease. (ptproductsonline.com)
Later work connected α-synuclein expression with several human brain pathologies, so that it is a major component of the Lewy bodies of Parkinson's disease. (neuromics.com)
Point mutations of α-synuclein proved to be causative of some forms of familial Parkinson's disease. (neuromics.com)
Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (alpha Syn), linking it to the pathophysiology of Parkinson's disease. (helsinki.fi)
Alpha-synuclein, a sticky and sometimes toxic protein involved in Parkinson's disease (PD), blocks signals from an important brain growth factor, researchers have discovered. (emoryhealthsciblog.com)
Together with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn) in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy body. (bmbreports.org)
Aggregation of misfolded alpha synuclein protein is a key feature of Parkinson's Disease (PD), which afflicts 53 million globally. (experiment.com)
α-Synuclein inhibitor 3 can be used for Parkinson's disease research. (medchemexpress.com)
AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. (medchemexpress.com)
SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson's disease. (medchemexpress.com)
Several lines of evidence implicate a central role for alpha-synuclein (aSN) in the pathogenesis of Parkinson's disease (PD). (unimib.it)
With Parkinson's disease due to the toxic buildup of alpha-synuclein protein a study in rats revealed. (theindianhour.com)
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). (signalchem.com)
In this review we report the different aspects of inflammation and immune system in Parkinson's disease, with particular interest in the possible role played by immune dysfunctions in PD, with focus on autoimmunity and processes involving infectious agents as a trigger and alpha-synuclein protein (α-syn). (frontiersin.org)
Parkinson's disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons. (fbk.eu)
Researchers have developed a computer model of the mouse brain that integrates both Parkinson's disease -related genetic risk factors and the animals' brain networks to help them understand how abnormal alpha-synuclein protein spreads and how neurodegeneration progresses. (parkinsonsnewstoday.com)
Alpha-synuclein was found to distinctly accumulate in different brain regions, including the substantia nigra, which is severely affected in Parkinson's disease, the hippocampus (involved in learning and memory), dorsal striatum (involved in voluntary movement), motor cortex and somatosensory cortex (processes sensations). (parkinsonsnewstoday.com)
Parkinson's disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. (parki-stgt.de)
We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson's disease. (parki-stgt.de)
The major objective of this study was to find outputative inhibitors of human alfa-synuclein to search possibletherapeutics of Parkinson's disease.Material and Methods: Our study included Moleculardocking study of 3D-Structure of alfa- synuclein of humanretrieved from PDB with their chemical ligands. (who.int)
Alpha-synuclein misfolds and forms aggregations in the brains of people with Parkinson's disease and related neurodegenerative disorders. (the-scientist.com)
ɑ-synuclein (ɑ-syn) progressively accumulates in age related neurodegenerative diseases such as Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). (researchsquare.com)
The Convergence of Dopamine and α-Synuclein: Implications for Parkinson's Disease. (qxmd.com)
AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. (qxmd.com)
Mutant α-Synuclein Overexpression Induces Stressless Pacemaking in Vagal Motoneurons at Risk in Parkinson's Disease. (qxmd.com)
Interaction of alpha-synuclein and dopamine metabolites in the pathogenesis of Parkinson's disease: a case for the selective vulnerability of the substantia nigra. (qxmd.com)
The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. (qxmd.com)
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. (qxmd.com)
Head injury, alpha-synuclein Rep1, and Parkinson's disease. (cdc.gov)
Antibodies against phosphorylated alpha-synuclein (aSyn) at S129 have emerged as the primary tools to investigate, monitor, and quantify aSyn pathology in the brain and peripheral tissues of patients with Parkinson's disease and other neurodegenerative diseases . (bvsalud.org)
Investigating a diagnostic marker for Parkinson's disease - a(alpha)-synuclein and/or associated protein DJ-I or parkin? (brainfoundation.org.au)
One of the hallmarks of Parkinson's disease is amyloid formation of a particular human protein, called alpha-synuclein. (neurosciencenews.com)
Dementia with Lewy bodies Dementia with Lewy bodies - caused by abnormal 'Lewy bodies' deposits of protein called alpha-synuclein inside of the brain's nerve cells - shares many similarities with Parkinson's disease. (alzheimer.ca)
Parkinson's disease and alpha synuclein: is Parkinson's disease a prion-like disorder? (wehaveparkinsons.com)
Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease. (cdc.gov)
Alpha-synuclein and familial Parkinson's disease. (cdc.gov)
In the second case, the mice did not show as many symptoms and the alpha-synuclein did not clump in the brain (this is what is believed to cause Parkinson's disease). (uaf.edu)

According to researchers from Aarhus University in Denmark, disease-causing proteins called alpha-synuclein travel up to the brain from the gut. (naturalnews.com)
Direct ELISA of purified anti-α-Synuclein Phospho (Tyr39) antibody (clone A15119B) binding to plate-immobilized recombinant human unmodified and pY39 and pY125 α-synuclein proteins. (biolegend.com)
This project intends to ID modifications to chaperone proteins to tailor them to target misfolded alpha synuclein. (experiment.com)
Recent research on small chaperone proteins suggests the possibility of a molecular switch, which, if modified, would greatly increase the protein's effectiveness and specificity in targeting misfolded alpha-synuclein. (experiment.com)
This optimized chaperone will be chosen to have higher performance in refolding A-synuclein than the native, endogenous chaperone proteins. (experiment.com)
Misfolded or excess alpha-synuclein proteins may cluster together to form Lewy bodies and impair the function of these neurons in specific regions of the brain. (medlineplus.gov)
Evidence indicates that in neurodegenerative diseases misfolded proteins, such as alpha-synuclein, spread through the brain along anatomically connected networks, inducing progressive decline. (parkinsonsnewstoday.com)
The molecular docking simulation results indicatethat the protein complexes were stable throughout MDsimulations and thus proteins possess the ability to stability.Conclusion: This study provides an insight of in-silico drugdesigning approach towards alfa- synuclein modulators as apromising therapeutics of Parkinson's's disease. (who.int)
N eurodegenerative diseases have long been associated with aggregations of apparently toxic proteins, whether that's amyloid precursor protein (APP) in Alzheimer's disease, α-synuclein in Parkinson's, or huntingtin in Huntington's. (the-scientist.com)
Parvalbumin effectively 'scavenges' the alpha-synuclein proteins, using them for its own purposes, thus preventing them from forming their own potentially harmful amyloids later on. (neurosciencenews.com)

Modulating the aggregation of alpha-synuclein and prion protein with small molecules. (uni-goettingen.de)
2) Inhibiting abnormal aggregation of alpha-synuclein and clearance of aggregates. (neuramedy.com)

Aggregated alpha-synuclein can be detected by anti-alpha synuclein filament antibody (ab209530), which is a conformation-specific antibody. (news-medical.net)
Immunohistochemistry (formaldehyde-fixed paraffin-embedded sections) of human DLB brain stained with anti-alpha synuclein filament antibody [MJFR14-6-4-2] (ab209538). (news-medical.net)
Retrieved on December 10, 2022 from https://www.news-medical.net/whitepaper/20180124/Conformation-Specific-Alpha-Synuclein-Antibody-for-Parkinsons-Disease.aspx. (news-medical.net)
Western blot of purified anti-α-Synuclein, 80-96 antibody (clone A15115A), and isotype-matched IgG1 control, demonstrating the binding specificity of clone A15115A to endogenous and recombinant human α-synuclein. (biolegend.com)
Direct ELISA of purified anti-α-Synuclein, C-Terminal Truncated antibody (clone A15127A) binding to plate-immobilized recombinant human full-length (1-140) and C-terminally fragmented (1-122) α-synuclein. (biolegend.com)
IHC staining of purified anti-α-Synuclein Phospho (Ser129) antibody (clone P-syn/81A) on formalin-fixed paraffin-embedded diseased human brain tissue. (biolegend.com)
Western blot of anti-α-Synuclein antibody (clone A15126D) and isotype-matched IgG2b control, binding to endogenous and recombinant human α-synuclein. (biolegend.com)
This antibody recognizes full length human and rodent α-synuclein specifically both in western blots and in immunocytochemical experiments and is a good marker of synapses on transgenic mice. (neuromics.com)
Human IgG antibody Laboratories manufactures the alpha synuclein elisa kit for mouse reagents distributed by Genprice. (aabioetica.org)
Description: A monoclonal antibody from clone 3C11 against Human Alpha Synuclein. (aabioetica.org)
Rabbit polyclonal Alpha-synuclein antibody Validated in WB ICCIF and tested in Mouse Rat Human Cited in 1 publications Immunogen corresponding to. (theindianhour.com)
Western Blot analysis of Human, Mouse, Rat Brain showing detection of 14 kDa Alpha Synuclein protein using Mouse Alpha Synuclein Antibody, 4F1 (Cat# S22-61DM). (signalchem.com)
Immunocytochemistry/Immunofluorescence analysis using Mouse Alpha Synuclein Antibody, 4F1 (Cat# S22-61DM). (signalchem.com)
C) Alpha Synuclein Antibody. (signalchem.com)

The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. (abcam.com)
Neurodegenerative diseases characterised by aggregates of the protein Alpha-Synuclein are referred to by the umbrella term Alpha-Synucleinopathies. (medillsb.com)
Closer examination of the substantia nigra reveals the formation of protein aggregates in which the main component is a misfolded form of the protein alpha-synuclein. (uni-goettingen.de)
Alpha-synuclein aggregates initially occur in a few discrete regions of the brain and gradually spread to wider brain areas. (neuramedy.com)
Under abnormal conditions, alpha-synuclein aggregates are released from neuronsand can reach neighboring neurons, affecting their function and viability. (neuramedy.com)
Alex describes the work he has been doing to understand how the protein alpha-synuclein aggregates to form pathological oligomers. (horrockslab.org)

Here, we investigated the link between PD-related mutant alpha-Synuclein (alpha-SYN) pathology and olfactory deficit, by examining the integration of adult-born neurons in the olfactory bulb (OB) of A30P alpha-SYN overexpressing mice. (uni-muenchen.de)
We therefore propose unstable integration and impaired homeostasis of functional new neurons as a likely contributor to odour discrimination deficits in mutant alpha-SYN mice. (uni-muenchen.de)
Primary rat hippocampal neurons show lewy body inclusion formation when treated with active Alpha Synuclein Protein Preformed Fibrils (GTX17669-pro) at 4 μg/ml (D-F), but not when treated with control Alpha Synuclein Protein Preformed Fibrils (GTX17667-pro) at 4 μg/ml (A-C). (genetex.com)
A similar bad actor in Parkinson's, alpha-synuclein, can also be detected in the LC before other parts of the brain that are well known for damage in Parkinson's, such as the dopamine neurons in the substantia nigra. (emoryhealthsciblog.com)
When applied to neurons, BDNF in turn sends alpha-synuclein away from TrkB. (emoryhealthsciblog.com)
In cultured neurons and in mice, alpha-synuclein inhibits BDNF's ability to protect brain cells from neurotoxins that mimic PD-related damage, Ye's team found. (emoryhealthsciblog.com)
Alpha-syn is a 14kDa protein made of 140 amino acids and found in the presynaptic ends of CNS neurons, acting as a chaperone and regulator. (usf.edu)
In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. (medlineplus.gov)
Tau-positive neuronal inclusions in neurons of the substantia nigra (no alpha synuclein-positive inclusions, as are found in Parkinson disease). (medscape.com)
The presence of cortical Lewy bodies is confirmed by the finding of alpha synuclein positive rounded cytoplasmic inclusion in neurons. (medscape.com)

Conformation-specific - Alpha-synuclein filaments/fibrils consisting of Lewy bodies are specifically labeled. (news-medical.net)
Active alpha synuclein preformed fibrils (GTX17669-pro) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (GTX17668-pro). (genetex.com)
Thioflavin T is a fluorescent dye that binds to beta sheet-rich structures, such as those in alpha synuclein fibrils. (genetex.com)
Thioflavin T emission curves show increased fluorescence (correlated to alpha synuclein protein aggregation) over time when 10 nM of active alpha synuclein preformed fibrils (GTX17669-pro) is combined with 100 μM of alpha synuclein monomer (GTX17668-pro), as compared to active alpha synuclein preformed fibrils (GTX17669-pro) alone and alpha synuclein monomer (GTX17668-pro) alone. (genetex.com)
SDS-PAGE of ~14 kDa active Human Recombinant Alpha Synuclein Protein Preformed Fibrils (GTX17669-pro). (genetex.com)
Lane 2: active Alpha Synuclein Protein Preformed Fibrils (GTX17669-pro). (genetex.com)
There are currently no references for Human alpha Synuclein protein (active, Pre-Formed Fibrils) (GTX17669-pro) . (genetex.com)

Alpha synuclein pathology is seen in the striatum close to an injection site. (genetex.com)
The LC is the earliest site to show tau pathology in AD and one of the earliest (but not the earliest) site to show alpha-synuclein pathology in PD," Weinshenker tells Lab Land. (emoryhealthsciblog.com)
The study, " Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis, " was published in Nature Neuroscience . (parkinsonsnewstoday.com)
Still, there were large regional differences in the degree and rate of alpha-synuclein pathology accumulation, namely within the hippocampus, substantia nigra and primary somatosensory cortex. (parkinsonsnewstoday.com)

Interestingly, in the different categories of genes identified, we found both genes which promote and reduce the formation of alpha-synuclein oligomers, suggesting it might be possible to interfere with the process in different ways. (michaeljfox.org)
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. (qxmd.com)
Repurposing doxycycline for synucleinopathies: remodelling of alpha-synuclein oligomers towards non-toxic parallel beta-sheet structured species. (cnrs.fr)

α-synuclein is a member of the synuclein protein family, the other two members being β and γ synuclein, each protein being coded for by a distinct but related gene. (neuromics.com)
Also, duplications of or mutations in the gene encoding alpha-synuclein drive some rare familial cases. (emoryhealthsciblog.com)
This, together with the fact that triplications and point mutations in the alpha-synuclein gene are associated with familial forms of PD makes alpha-synuclein an optimal target for research. (uni-goettingen.de)
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. (cdc.gov)

The program's goal is to quickly move into clinical testing of new candidates with the potential to become a first-in-class PET tracer for pathological alpha-synuclein. (ptproductsonline.com)
Alpha-synuclein is a major component of Lewy bodies, the protein clumps that are a pathological sign of PD. (emoryhealthsciblog.com)
Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. (bvsalud.org)

This hypothesis was confirmed when scientists observed a greater buildup of alpha-synuclein in specific brains regions of LRRK2 G2019S mutated mice, while those same areas were less vulnerable to abnormal cellular changes in non-mutated animals. (parkinsonsnewstoday.com)

The study reveals the protein parvalbumin can help to prevent the formation of alpha synuclein. (neurosciencenews.com)

Scyllo-Inositol, an amyloid inhibitor , potentialy inhibits α-synuclein aggregation. (medchemexpress.com)
Ubiquitination Can Change the Structure of the Synuclein Amyloid Fiber in a Site Selective Fashion Stuart P Moon. (theindianhour.com)
By increasing amounts of molecular waste in the brain such as amyloid- synuclein tau and a few others. (theindianhour.com)
While in AD, amyloid beta (Aβ), and tau play a central role, in DLB and PD ɑ-synuclein (ɑ-syn) is a key mediator 2-6 . (researchsquare.com)
What the Chalmers researchers have now discovered, is that parvalbumin can form amyloid structures that bind together with the alpha-synuclein protein. (neurosciencenews.com)

α-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy and amyotrophic lateral sclerosis. (neuromics.com)
Three months after injection, alpha-synuclein had produced Lewy body-like cellular inclusions. (parkinsonsnewstoday.com)
Alpha-synuclein staining of the pons of an MSA case showing the positive glial inclusions (40x). (medscape.com)

Neuronal α-Synuclein is concentrated in presynaptic nerve terminals, interacts with plasma membrane phospholipids, and is also present in nuclei and mitochondria. (biolegend.com)
Using in vivo two-photon imaging, we followed the dynamic process of neuronal turnover in transgenic A30P alpha-SYN and wild-type mice over a period of 2.5 months. (uni-muenchen.de)
Importantly, mutated mice had no accumulation of alpha-synuclein if they were not injected with abnormal alpha-synuclein first, suggesting LRRK2 G2019S may not initiate disease by itself, but rather alter neuronal vulnerability to the disorder. (parkinsonsnewstoday.com)
Lewy bodies are mainlycomposed of alpha-synuclein.Oligomeric and fibrillar structures of alpha-synucleinmay promoteneuroinflammation and neuronal death. (neuramedy.com)

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration. (qxmd.com)
Thanks to continued research, experts now know that a primary cause of Parkinson's is mitochondrial dysfunction, with secondary causes being neural oxidation, neural inflammation, and alpha-synuclein aggregation all causing a toxic overload on surrounding neural cells in the substantia nigra. (wehaveparkinsons.com)

Risikopatienten mit REM-Schlaf-Verhaltensstörung weisen in der Haut den Biomarker Alpha-Synuclein auf, und zwar Jahre bevor die Betroffenen sichtbar an Parkinson erkranken. (parki-stgt.de)
Parkinson - Das Protein Alpha-Synuclein ist schwer zu fassen. (parki-stgt.de)
Some pesticides , such as the organophosphorus insecticide chlorpyrifos, appear to increase the expression of a-synuclein, a protein critically involved in Parkinson disease. (cdc.gov)

α-synuclein was originally isolated as a major synaptic vesicle associated protein from the electric organ of the fish Torpedo, and direct homologues of α-synuclein are found in all vertebrates. (neuromics.com)
α-synuclein is normally heavily expressed in brain and appears to be localized primarily to presynaptic regions, though not with a typical synaptic vesicle distribution pattern. (neuromics.com)
Although the function of alpha-synuclein is not well understood, studies suggest that it plays an important role in maintaining an adequate supply of synaptic vesicles in presynaptic terminals. (medlineplus.gov)
Alpha-synuclein is a presynaptic proteinthat regulates synaptic transmission.It is an intrinsically disordered "flexible" protein. (neuramedy.com)

The finding adds to evidence that alpha-synuclein is a pivot for damage to brain cells in PD, and helps to explain why brain cells that produce the neurotransmitter dopamine are more vulnerable to degeneration. (emoryhealthsciblog.com)

A characteristic feature of this condition is Lewy bodies, which are abnormal clusters of alpha-synuclein protein in the brain. (medlineplus.gov)
LBD is associated with abnormal brain deposits of a protein called alpha-synuclein. (medlineplus.gov)

Alpha-Synuclein is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals. (abcam.com)

Endogenous alpha-synuclein phosphorylation. (genetex.com)

Is characterized by the accumulation of misfolded synuclein as Lewy bodies. (theindianhour.com)

Our earlier results have revealed that the potent small molecular PREP inhibitor KYP-2047 is able to increase autophagy and decrease dimerization of alpha Syn but other PREP inhibitors have not been systematically studied for these two protein-protein interaction mediated biological functions of PREP. (helsinki.fi)
We used protein-fragment complementation assay (PCA) to assess alpha Syn dimerization and Western Blot of microtubule-associated protein light chain 3B II (LC3B-II) and a GFP-LC3-RFP expressing cell line to study autophagy. (helsinki.fi)
In addition, we tested selected compounds in a cell-free alpha Syn aggregation assay, native gel electrophoresis, and determined the compound concentration inside the cell by LC-MS. We found that inhibition of the proteolytic activity of PREP did not predict decreased alpha Syn dimerization or increased autophagy, and we also confirmed that this result did not simply reflect concentration differences of the compounds inside the cell. (helsinki.fi)
Thus, PREP ligands regulate the effect of PREP on autophagy and alpha Syn aggregation through a conformational stabilization of the enzyme that is not equivalent to inhibiting its proteolytic activity. (helsinki.fi)

Alpha-synuclein and mitochondrial dysfunction: key links between Gaucher's disease and Parkinson's? (fabiodisconzi.com)
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. (wehaveparkinsons.com)

The insertion of alpha-synculein into the membrane can be prevented by a small chemical compound, opening a novel approach to block aggregation and toxicity of alpha-synuclein. (uni-goettingen.de)

abstract = "Interactions of monomeric alpha-synuclein (αS) with lipid membranes have been suggested to play an important role in initiating aggregation of αS. (utwente.nl)

There is increasing evidence that misfolded aggregated Alpha-Syn is the causative agent in Synucleinopathies, which has constituted a significant advance in our understanding of these diseases. (medillsb.com)
Alpha-synuclein (α-syn) aggregation is a neuropathological hallmark of many neurodegenerative diseases, collectively termed synucleinopathies. (eurekaselect.com)
In the case of synucleinopathies cerebrospinal alpha-synuclein syn. (theindianhour.com)
A synuclein that is a major component of LEWY BODIES and plays a role in SYNUCLEINOPATHIES , neurodegeneration and neuroprotection. (bvsalud.org)

100 μM alpha synuclein protein monomer (GTX17668-pro) seeded with 10 nM alpha synuclein protein PFF (GTX17669-pro) in 25 μM Thioflavin T (PBS pH 7.4, 100 μl reaction volume) generated a fluorescence intensity of 13,000 Relative Fluorescence Units after incubation at 37ºC with shaking at 600 rpm. (genetex.com)
The antigen used for immunization is Human alpha synuclein monomer. (aabioetica.org)

This second period of funding enabled us to proceed with the RNAi screen and to identify additional modifiers of alpha-synuclein oligomerization. (michaeljfox.org)

Here, we review the concept of α-synuclein nitration and its biological consequences. (parki-stgt.de)

The major component of these Lewy Bodies is a protein called alpha-synuclein. (usf.edu)

The ability to visualize alpha-synuclein in the living brain could accelerate the development of new therapies for Parkinson's and be an important new diagnostic tool for physicians. (ptproductsonline.com)
Immunohistochemistry analysis of rat brain injected with active human alpha synuclein PFFs (GTX17669-pro). (genetex.com)
The strong band at about 15kDa corresponds to the α-synuclein protein in brain extracts, which are rich in synapses, while a weaker band is seen in spinal cord extracts where synapses are a more minor component. (neuromics.com)
Alpha-Syn is widely expressed in the brain. (medillsb.com)
In the current paper, researchers led by Keqiang Ye, PhD demonstrated that alpha-synuclein binds and interferes with TrkB, the receptor for BDNF (brain derived neurotrophic factor). (emoryhealthsciblog.com)
Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. (medlineplus.gov)
Researchers injected a toxic form of the alpha-synuclein protein into the dorsal striatum, a brain area involved in motor control, of 3-month-old mice and evaluated the protein buildup at 1, 3, and 6 months post-injection. (parkinsonsnewstoday.com)
When the team compared the protein accumulations from the mouse brains to the computational model, alpha-synuclein was found to spread primarily along specific brain pathways. (parkinsonsnewstoday.com)
In conclusion, a brain network computer-based model that visualizes alpha-synuclein spreading and takes into account both brain connectivity and genetic background may become a reliable way to test different protein spreading scenarios. (parkinsonsnewstoday.com)
Neuron-derived alpha-synuclein also reacts with TLR2 on neighboring glial cells,resulting in inflammation ofthe brain parenchyma. (neuramedy.com)
It was found that the gut microbiome of diseased patients caused alpha-synuclein, the substance present in Parkinson's patients, to clump in the brain compared to the gut microbiome of a healthy person transferred to mice with high levels of alpha-synuclein. (uaf.edu)

But did you know that there are different 'species' of alpha synuclein? (scienceofparkinsons.com)
In today's post, we will discuss what is meant by the word 'species', look at the different species of alpha synuclein, and explore what this new species could mean for the Parkinson's community. (scienceofparkinsons.com)

Extracellular alpha-synuclein is cleared by extracellular proteolytic enzymes or taken up by neighboring cells especially microglia and astrocytes and degraded within lysosomes. (theindianhour.com)

TLR2 also mediates neuron-to-neuron propagation of alpha-synuclein. (neuramedy.com)

Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. (parki-stgt.de)

In this experiment, I use antibodies, 1H5 and 2A4, to quickly identify relative amounts of alpha-syn in human PD blood plasma. (usf.edu)
We just released TWO brand-new Alpha-Synuclein antibodies! (antibodiesinc.com)

ELISA was performed by coating wells with 150 ng of each recombinant α-synuclein protein. (biolegend.com)
The Alpha Synuclein Elisa Kit For Mouse reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (aabioetica.org)
Description: A competitive ELISA for quantitative measurement of Mouse Alpha Synuclein oligomer in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (aabioetica.org)

We also discovered that some of the modifiers altered the intracellular distribution pattern of alpha-synuclein, and we are now exploring these effects in more detail in follow-up studies. (michaeljfox.org)
Stuiver M van Rossum M Selenko P Intracellular repair of oxidation-damaged alpha-synuclein fails to target C-terminal modification sites Nat Commun. (theindianhour.com)

Researchers are working to determine whether these changes alter the function of alpha-synuclein and how they influence the risk of developing multiple system atrophy. (medlineplus.gov)

Recombinant full length protein within Human Alpha-synuclein aa 1 to the C-terminus. (abcam.com)
Marie Kosco-Vilbois, PhD, Chief Scientific Officer at AC Immune , leads a team that has successfully used the company's innovative Morphomer discovery platform to advance two alpha-synuclein tracers to human clinical testing. (ptproductsonline.com)

and α-Synuclein-112, which lacks residues 103-130. (biolegend.com)

The Roles of Post-translational Modifications on Synuclein. (theindianhour.com)

One type changes single protein building blocks (amino acids) used to make alpha-synuclein. (medlineplus.gov)

We report an incidental 358.5 kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double knockout (DKO) mouse line previously developed by Tolmachova and colleagues in 2007. (nature.com)

synuclein a clinical-stage biopharmaceutical company that is developing disease-modifying therapies for neurodegenerative diseases announced that. (theindianhour.com)

Anatomy3

Organisms1

Diseases3

Chemicals and Drugs23

Psychiatry and Psychology1

Phenomena and Processes1

Information Science2

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. (1/1546)

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. (2/1546)

Copper(II)-induced self-oligomerization of alpha-synuclein. (3/1546)

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. (4/1546)

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. (5/1546)

Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. (6/1546)

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. (7/1546)

The genetics of disorders with synuclein pathology and parkinsonism. (8/1546)

alpha-Synuclein

Synucleins

gamma-Synuclein

Impulse Control Disorders

beta-Synuclein

Parkinson Disease

Dopamine

Protein D-Aspartate-L-Isoaspartate Methyltransferase

Lewy Bodies

Nerve Tissue Proteins

Parkinsonian Disorders

Neurodegenerative Diseases

Molecular Sequence Data

Neurons

Amino Acid Sequence

alpha 1-Antitrypsin

Brain

Receptors, Adrenergic, alpha

Mice, Transgenic

Hypoxia-Inducible Factor 1, alpha Subunit

alpha7 Nicotinic Acetylcholine Receptor

Integrin alpha3beta1

Integrin alpha4

Integrin alpha6

Integrin alpha5beta1

Integrin alpha4beta1

Interleukin-1alpha

Integrin alpha2beta1

Receptors, Adrenergic, alpha-1

Integrin alpha5

Integrin alpha1beta1

Receptors, Adrenergic, alpha-2

Integrin alpha6beta1

Mutant and wild type human alpha-synucleins assemble into elongated filaments with distinct morphologies in vitro. (1/1546)

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. (2/1546)

Copper(II)-induced self-oligomerization of alpha-synuclein. (3/1546)

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. (4/1546)

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. (5/1546)

Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. (6/1546)

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356. (7/1546)

The genetics of disorders with synuclein pathology and parkinsonism. (8/1546)

Alpha-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport i by Nandhakumar Thayanidhi, Jared R. Helm et al.

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage<...

A Focus on the Beneficial Effects of Alpha Synuclein and a Re-Appraisal of Synucleinopathies | Bentham Science

Alpha-Synuclein Detection: ELISAs and Antibodies

Alpha-Synuclein Detection: ELISAs and Antibodies

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinsons disease ...

Assay Solution. Rat alpha-Synuclein ELISA Kit

Assay Solution. Porcine alpha-Synuclein ELISA Kit

Anti-amyloid Oligomer Monoclonal Antibodies for Treatment of Parkinsons Disease | Parkinsons Disease

Evaluation of the Oligomer Modulator anle138b in a Seeding-based Model of Parkinsons Disease | Parkinsons Disease

PNAS: Polyamine pathway plays a role in Parkinsons disease pathogenesis | Health Imaging

IJMS | Free Full-Text | High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors

Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment | Acta...

Volume 20.06 | Feb 25 - Cell Therapy News

Lyme discovery: Borrelia bacteria hides inside parasitic worms, causing chronic brain diseases - Outbreak News Today

Lyme discovery: Borrelia bacteria hides inside parasitic worms, causing chronic brain diseases - Outbreak News Today

Understanding the membrane biophysics of alpha-Synuclein and its role in membrane curvature induction and structural remodeling

Study Identifies Novel Parkinsons Disease Drug Target | EmaxHealth

Modelling the evolution of PD from gut to brain - Parkinsons Movement

Serval - The role of phosphorylation at Y125 in regulating the structure, aggregation, and membrane binding of alpha-synuclein:...

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

Extracellular alpha-synuclein contributes to gsk-3beta-dependent Tau phosphorylation in PC12 dopaminergic cells: Its role in...

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinsons Disease

Researchers shed light on why exercise slows progression of Parkinsons disease | Science Codex

Synucleinopathies: January 2016

A Vaccine for Parkinsons - Developments in Immunotherapy | The Cure Parkinsons Trust

Alpha-Synuclein Aggregation and Membrane Association in a Fission Yea by Lokesh Kukreja

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice | Science

Biomolecules | Free Full-Text | Sirtuins and Proteolytic Systems: Implications for Pathogenesis of Synucleinopathies

Alpha-synuclein (human) AlphaLISA Detection Kit, 500 Assay Points | PerkinElmer

Formation of a high affinity lipid-binding intermediate during the early aggregation phase of alpha-synuclein

Regulation and targeting of enzymes mediating Parkinsons disease pathogenesis: focus on Parkinsons disease Kinases, GTPases...

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinsons disease - Nuffield Department of...

Neurodegeneration - Wikipedia

Neurodegeneration - Wikipedia

Proteins in migration ( This news release is available in...)

Paul Kotzbauer, MD, PhD

Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease<...