Inhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyalpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.alpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Integrin alpha3beta1: Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.Integrin alpha4: An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.Integrin alpha6: An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.Integrin alpha5beta1: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Interleukin-1alpha: An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.Integrin alpha2beta1: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Integrin alpha5: This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.Integrin alpha1beta1: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.Receptors, Adrenergic, alpha-2: A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Integrin alpha6beta4: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.Integrin alpha Chains: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Integrin alpha1: An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.Alpha Rhythm: Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.Integrin alpha3: An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.PPAR alpha: A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Hepatocyte Nuclear Factor 1-alpha: Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.alpha 1-Antichymotrypsin: Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.Transforming Growth Factor alpha: An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Kinetics: The rate dynamics in chemical or physical systems.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Adrenergic alpha-1 Receptor Antagonists: Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.alpha Karyopherins: Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.6-Ketoprostaglandin F1 alpha: The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.Protein Subunits: Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Mice, Inbred C57BLDose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.GTP-Binding Proteins: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Interleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Adrenergic alpha-2 Receptor Agonists: Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

The extracellular matrix in the mouse brain: its reactions to endo-alpha-N-acetylgalactosaminidase and certain other enzymes. (1/59)

As our previous studies have indicated, the cingulate cortex of the adult mouse brain contains many neurons with rich cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The present study demonstrated that exclusive incubation with endo-alpha-N-acetylgalactosaminidase abolished the lectin Vicia villosa or Wisteria floribunda agglutinin (VVA or WFA) labeling of the nerve cell surface glycoproteins, while it neither interfered with the cationic iron colloid or aldehyde fuchsin stainings of the perineuronal proteoglycans nor abolished the Gomori's ammoniacal silver impregnation of the collagenous ligands. Double incubations with endo-alpha-N-acetylgalactosaminidase and collagenase did not eliminate the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, though they did eliminate the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans as well as the Gomori's ammoniacal silver impregnation of the collagenous ligands. Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori's ammoniacal silver impregnation of the collagenous ligands. These findings indicate that: the nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase; these galactosamines associated with the collagenous ligands or perineuronal proteoglycans are not digested by endo-alpha-N-acetylgalactosaminidase; and the terminal N-acetylgalactosamines newly exposed by collagenase incubation are digested by this galactosaminidase. It was further demonstrated that hyaluronidase incubation neither digests the collagenous ligands nor revives the lectin VVA or WFA labeling of the nerve cell surface proteoglycans.  (+info)

Glycoprotein lysosomal storage disorders: alpha- and beta-mannosidosis, fucosidosis and alpha-N-acetylgalactosaminidase deficiency. (2/59)

Glycoproteinoses belong to the lysosomal storage disorders group. The common feature of these diseases is the deficiency of a lysosomal protein that is part of glycan catabolism. Most of the lysosomal enzymes involved in the hydrolysis of glycoprotein carbohydrate chains are exo-glycosidases, which stepwise remove terminal monosaccharides. Thus, the deficiency of a single enzyme causes the blockage of the entire pathway and induces a storage of incompletely degraded substances inside the lysosome. Different mutations may be observed in a single disease and in all cases account for the nonexpression of lysosomal glycosidase activity. Different clinical phenotypes generally characterize a specific disorder, which rather must be described as a continuum in severity, suggesting that other biochemical or environmental factors influence the course of the disease. This review provides details on clinical features, genotype-phenotype correlations, enzymology and biochemical storage of four human glycoprotein lysosomal storage disorders, respectively alpha- and beta-mannosidosis, fucosidosis and alpha-N-acetylgalactosaminidase deficiency. Moreover, several animal disorders of glycoprotein metabolism have been found and constitute valuable models for the understanding of their human counterparts.  (+info)

Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides. (3/59)

Human alpha-N-acetylgalactosaminidase (alpha-GalNAc; also known as alpha-galactosidase B) is the lysosomal exoglycohydrolase that cleaves alpha-N-acetylgalactosaminyl moieties in glycoconjugates. Mutagenesis studies indicated that the first five (N124, N177, N201, N359, and N385) of the six potential N-glycosylation sites were occupied. Site 3 occupancy was important for enzyme function and stability. Characterization of the N-linked oligosaccharide structures on the secreted enzyme overexpressed in Chinese hamster ovary cells revealed highly heterogeneous structures consisting of complex (approximately 53%), hybrid (approximately 12%), and high mannose-type (approximately 33%) oligosaccharides. The complex structures were mono-, bi-, 2,4-tri-, 2,6-tri-, and tetraantennary, among which the biantennary structures were most predominant (approximately 53%). Approximately 80% of the complex oligo-saccharides had a core-region fucose and 50% of the complex oligosaccharides were sialylated exclusively with alpha-2,3-linked sialic acid residues. The majority of hybrid type oligo-saccharides were GalGlcNAcMan(6)GlcNAc-Fuc(0-1)GlcNAc. Approximately 54% of the hybrid oligosaccharide were phosphorylated and one-third of these structures were further sialylated, the latter representing unique phosphorylated and sialylated structures. Of the high mannose oligosaccharides, Man(5-7)GlcNAc(2) were the predominant species (approximately 90%) and about 50% of the high mannose oligosaccharides were phosphorylated, exclusively as monoesters whose positions were determined. Comparison of the oligosaccharide structures of alpha-GalNAc and alpha-galactosidase A, an evolutionary-related and highly homologous exoglycosidase, indicated that alpha-GalNAc had more completed complex chains, presumably due to differences in enzyme structure/domains, rate of biosynthesis, and/or aggregation of the overexpressed recombinant enzymes.  (+info)

Blood group A antigen is a coreceptor in Plasmodium falciparum rosetting. (4/59)

The malaria parasite Plasmodium falciparum utilizes molecules present on the surface of uninfected red blood cells (RBC) for rosette formation, and a dependency on ABO antigens has been previously shown. In this study, the antirosetting effect of immune sera was related to the blood group of the infected human host. Sera from malaria-immune blood group A (or B) individuals were less prone to disrupt rosettes from clinical isolates of blood group A (or B) patients than to disrupt rosettes from isolates of blood group O patients. All fresh clinical isolates and laboratory strains exhibited distinct ABO blood group preferences, indicating that utilization of blood group antigens is a general feature of P. falciparum rosetting. Soluble A antigen strongly inhibited rosette formation when the parasite was cultivated in A RBC, while inhibition by glycosaminoglycans decreased. Furthermore, a soluble A antigen conjugate bound to the cell surface of parasitized RBC. Selective enzymatic digestion of blood group A antigen from the uninfected RBC surfaces totally abolished the preference of the parasite to form rosettes with these RBC, but rosettes could still form. Altogether, present data suggest an important role for A and B antigens as coreceptors in P. falciparum rosetting.  (+info)

Adhesion of human lung mast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism. (5/59)

Mast cells contribute to the pathophysiology of asthma through their immunomediator-secretory activity in response to both immunological and nonimmunological stimuli, and infiltrate the bronchial epithelium in this disease. We hypothesized that human lung mast cells (HLMC) localize to the bronchial epithelium via a specific cell-cell adhesion mechanism. We investigated the adhesion of HLMC to primary bronchial epithelial cells and the bronchial epithelial cell line BEAS-2B. HLMC adhered avidly to both primary cultures of bronchial epithelial cells and BEAS-2B cells (mean adhesion 68.4 and 60.1%, respectively) compared with eosinophil adhesion to BEAS-2B (mean adhesion 10.3%). HLMC adhesion did not alter after epithelial activation with cytokines, did not require Ca2+, and was not integrin-mediated. IgE-dependent activation of HLMC produced an approximately 40% inhibition of adhesion. There was significant attenuation of adhesion after incubation of HLMC with pronase, beta-galactosidase, and endo-alpha-N-acetylgalactosaminidase, indicating that HLMC adhere to bronchial epithelial cells via galactose-bearing carbohydrates expressed on a cell-surface peptide(s).  (+info)

Trypsin inhibitory activity of bovine fetuin de-O-glycosylated by endo-alpha-N-acetylgalactosaminidase. (6/59)

The effects of bovine fetuin O-glycans on its trypsin inhibitory activity were examined. De-sialylated (asialo-) and de-O-glycosylated fetuin were prepared from native fetuin using Arthrobacter neuraminidase and the mixture of it and Bacillus endo-alpha-N-acetylgalactosaminidase, respectively. De-sialylation and de-O-glycosylation from fetuin were confirmed with SDS-PAGE followed by western blotting using anti-human Thomsen-Friedenreich antigen (T antigen) antibody which recognizes O-linked galactosyl beta1,3 N-acetylgalactosamine (Gal beta1-->3GalNAc). Native fetuin completely inhibited the trypsin activity at about a 1:1 molar ratio. In contrast, the trypsin inhibitory activity of asialo- and de-O-glycosylated fetuin decreased about a half and one-third of that of native fetuin, respectively.  (+info)

Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: no association with neuroaxonal dystrophy? (7/59)

Two new individuals with alpha-NAGA deficiency are presented. The index patient, 3 years old, has congenital cataract, slight motor retardation and secondary demyelinisation. Screening of his sibs revealed an alpha-NAGA deficiency in his 7-year-old healthy brother who had no clinical or neurological symptoms. Both sibs are homozygous for the E325K mutation, the same genotype that was found in the most severe form of alpha-NAGA deficiency presenting as infantile neuroaxonal dystrophy. Thus, at the age of 7 years the same genotype of alpha-NAGA may present as a 'non-disease' (present healthy case) and can be associated with the vegetative state (the first two patients described with alpha-NAGA deficiency). The clinical heterogeneity among the 11 known individuals with alpha-NAGA deficiency is extreme, with a 'non-disease' (two cases) and infantile neuroaxonal dystrophy (two cases) at the opposite sides of the clinical spectrum. The broad spectrum is completed by a very heterogeneous group of patients with various degrees of epilepsy/behavioural difficulties/psychomotor retardation (four patients) and a mild phenotype in adults without overt neurological manifestations who have angiokeratoma and clear vacuolisation in various cell types (three cases). These observations are difficult to reconcile with a straightforward genotype-phenotype correlation and suggest that factors or genes other than alpha-NAGA contribute to the clinical heterogeneity of the 11 patients with alpha-NAGA deficiency.  (+info)

Efficient synthesis of O-linked glycopeptide by a transglycosylation using endo alpha-N-acetylgalactosaminidase from Streptomyces sp. (8/59)

Gal beta-(1-->3)-GalNAc-linked hexapeptide was synthesized by a transglycosylation using Gal beta-(1-->3)-GalNAc beta-pNP as a donor and a serine-containing hexapeptide as an acceptor using endo GalNAc-ase from Streptomyces sp.. The Gal beta-(1-->3)-GalNAc residue was transferred to the hydroxyl group of the serine residue of the peptide. The total yield of the glycopeptide via this process was better than that of the chemoenzymatic method. This process was confirmed to be a versatile method for the synthesis of O-linked glycopeptides.  (+info)

Schindler Disease Type 1 (Alpha-N-Acetylgalactosaminidase Deficiency Type 1): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
Not many students can list a prestigious journal as the publication where their first academic research paper appeared, but such is the case for Schindler. Co-authored with his supervisor Gabriel Comita, his research using the calorimeter to determine the energy content of small aquatic organisms including copepods, algae, and crayfish, was published in Science in 1963. Publishing for the very first time in one of the worlds premier science journals was perhaps to foreshadow the prominent role of the science Schindler has researched and published throughout his continuing career.. Schindlers PhD studies focused on lakes from an ecosystem perspective, studying initially with Nikko Tinbergen and then Charles Elton. Following completion of his PhD at Oxford, Schindler headed to Trent University in the small town of Peterborough, Ontario, a setting that appealed to Schindler because of its geological diversity and the many surrounding lakes. During his first year at Trent, Schindler learned about ...
Alpha-N-acetylgalactosaminidase (NAGA) deficiency is a very rare lysosomal storage disorder. It is clinically heterogeneous with 3 main phenotypes: type I is an infantile-onset neuroaxonal dystrophy; type II, also known as Kanzaki disease ({609242}), is an adult-onset disorder characterized by angiokeratoma corporis diffusum and mild intellectual impairment; and type III is an intermediate disorder with mild to moderate neurologic manifestations ({3:Desnick and Schindler, 2001 ...
Clark, NE, Garman, SC. The 1.9 A structure of human alpha-N-acetylgalactosaminidase: The structural basis of Schindler and Kanzaki diseases. Journal of Molecular Biology. 2009, Oct 23;393(2):435-447. [PubMed]. Ishii S, Chang HH, Kawasaki K, Yasuda K, Wu HL, Garman SC, Fan JQ. Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin. Biochem J. 2007 Sep 1;406(2):285-95.[PubMed]. Hebert DN, Garman SC, Molinari M. (2005) "The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags." Trends Cell Biol. Jul;15(7):364-70. Review.[PubMed]. Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN. (2005) "The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies." Proc Natl Acad Sci U S A. Mar 22;102(12):4240-5. Epub 2005 Mar 10. [PubMed]. Ries ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Sodium atom in PDB 3ecq: Endo-Alpha-N-Acetylgalactosaminidase From Streptococcus Pneumoniae: Semet Structure
Eze, Ikenna C; Foraster, Maria; Schaffner, Emmanuel; Vienneau, Danielle; Héritier, Harris; Rudzik, Franziska; Thiesse, Laurie; Pieren, Reto; Imboden, Medea; von Eckardstein, Arnold; Schindler, Christian; Brink, Mark; Cajochen, Christian; Wunderli, Jean-Marc; Röösli, Martin; Probst-Hensch, Nicole (2017). Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study. International Journal of Epidemiology, 46(4):1115-1125.. Boillat-Blanco, Noémie; Bovet, Pascal; Ramaiya, Kaushik L; Mganga, Maliwasa; Minja, Lilian T; Saleh, Lanja; Imboden, Medea; Schindler, Christian; Gagneux, Sebastien; Daubenberger, Claudia; Reither, Klaus; Probst-Hensch, Nicole (2016). Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study. BMC Infectious Diseases, 16(1):626.. Eze, Ikenna C; Imboden, Medea; Kumar, Ashish; von Eckardstein, Arnold; Stolz, Daiana; Gerbase, Margaret W; Künzli, Nino; Pons, Marco; ...
Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. ...
In 2014, Dr. Tom deTar raised close to $27,000 for the Anna Schindler Foundation in his successful bid to complete the 2014 IRONMAN CDA. He blew past all expectations and his dedication and charity have already helped the Foundation carry out its mission of supporting kids with cancer.. In 2015, nine athletes competed in the IRONMAN for Anna race, June 28th, raising over $31,000 for childhood cancer families. In 2016, 11 athletes did the IM CDA 70.3 & 140.6 raising $19,000 for our cause.. ...
Bobby Schindler, Terris brother, told WorldNetDaily Schiavo is distorting the conversation that triggered the rift between the Schindlers and the Schiavos. My father was seeking money for Terris rehabilitation, which Michael Schiavo was refusing to give her, he said, calling Schiavos accusation ironic. In June of 1993, eight months after he got the malpractice money, he tried to kill Terri by withholding antibiotics needed to treat an infection. There was $800,000 in the fund at the time, Bobby Schindler said. According to court records, the caregivers at the nursing home overruled Schiavos order and treated Terri for her infection. As additional proof that hes not in the legal battle for the money, Schiavo told King he offered three times to donate the money to charity two years ago. But Bobby Schindler called it a hollow offer. The offer came with the stipulation that my parents agree to let my sister starve to death. Why would we let her starve to death?, Schindler told ...
Holly Schindler is the author of three previous YA novels: PLAYING HURT as well as the critically acclaimed FERAL (starred PW review) and A BLUE SO DARK (starred Booklist review, ForeWord Book of the Year silver medal, IPPY gold medal). A writer of books for all ages, Schindlers MG, THE JUNCTION OF SUNSHINE AND LUCKY, has made the master list for childrens book awards in Illinois, South Carolina, and Alabama. She is also a hybrid author, having independently released comedic womens fiction (FIFTH AVENUE FIDOS) and the forthcoming PLAY IT AGAIN, her adult follow-up to her YA PLAYING HURT. She can be reached through her author site: hollyschindler.com, and hosts special sneak peeks and giveaways for subscribers of her newsletter: tinyletter.com/hollyschindler.com. ...
Free Essays from Bartleby | When Schindler finally realized the true cruelty of the Holocaust, his once selfish nature shifted into one of complete...
Chesapeake Life Center invites the community to the 11th annual Emily Schindler Memorial Lecture titled The Trauma Whisperers: What Works in Contemporary Trauma Treatment presented by Daniel L. Buccino, LCSW-C, BCD, from 9 a.m. to 12:15 p.m. Wednesday, May 25, 2016, at Anne Arundel Community College, 7000 Arundel
Studies are reported on Alpha-Galactosidase and Conversion of Group B Erythrocytes and (2) Isolation and Characterization of Alpha-N-Acetylgalactosaminidase.*Enzymes
Recently approved by the U.S. Food and Drug Administration, VenaSeal is a minimally invasive procedure that permanently treats varicose veins located close to the surface of the skin. "Unlike previous treatment options, VenaSeal involves fewer injections along the length of the leg and is less painful," explained Dr. Schindler, who holds an academic appointment at the University of Chicago Pritzker School of Medicine.. During the outpatient procedure, Dr. Schindler inserts a catheter through the skin and injects a small amount of medical glue to seal off the abnormal vein, restoring normal blood flow. "In Pats case, we were able to perform the VenaSeal procedure on both legs during the same appointment, which isnt always possible with other treatment options," added Dr. Schindler.. "It was unbelievable how much better I felt right away," exclaimed Kelley. "Now my pain is gone and my energy level is back to normal. Im so grateful to my NorthShore physicians who were so reassuring. I just cant ...
Itoh, T., Ochiai, A., Mikami, B., Hashimoto, W. and Murata, K. (2006). "A novel glycoside hydrolase family 105: the structure of family 105 unsaturated rhamnogalacturonyl hydrolase complexed with a disaccharide in comparison with family 88 enzyme complexed with the disaccharide". J. Mol. Biol. 360: 573-585. PMID 16781735. ...
Gelbard, A., Anderson, C., Berry, L. D., Amin, M. R., Benninger, M. S., Blumin, J. H., Bock, J. M., Bryson, P. C., Castellanos, P. F., Chen, S. C., Clary, M. S., Cohen, S. M., Crawley, B. K., Dailey, S. H., Daniero, J. J., De Alarcon, A., Donovan, D. T., Edell, E. S., Ekbom, D. C., Fernandes-Taylor, S. 及其他55, Fink, D. S., Franco, R. A., Garrett, C. G., Guardiani, E. A., Hillel, A. T., Hoffman, H. T., Hogikyan, N. D., Howell, R. J., Huang, L. C., Hussain, L. K., Johns, M. M., Kasperbauer, J. L., Khosla, S. M., Kinnard, C., Kupfer, R. A., Langerman, A. J., Lentz, R. J., Lorenz, R. R., Lott, D. G., Lowery, A. S., Makani, S. S., Maldonado, F., Mannion, K., Matrka, L., McWhorter, A. J., Merati, A. L., Mori, M. C., Netterville, J. L., ODell, K., Ongkasuwan, J., Postma, G. N., Reder, L. S., Rohde, S. L., Richardson, B. E., Rickman, O. B., Rosen, C. A., Rutter, M. J., Sandhu, G. S., Schindler, J. S., Schneider, G. T., Shah, R. N., Sikora, A. G., Sinard, R. J., Smith, M. E., Smith, L. J., Soliman, ...
Pregnancy is a time of anticipation. And for many parents, its also a time of worry, mostly over the health of the unborn child. But Bostons medical establishment is on the cutting edge of advances that can allay expectant parents fears over the congenital abnormalities and diseases that can be passed down to new generations. No test yet exists to screen for all problems, but there are a few specific exams that parents can now utilize. For example, a new procedure to check for Down syndrome is being tried at the New England Medical Center, part of a national study sponsored by the National Institutes of Health.. Down syndrome is a congenital disorder caused by a chromosome abnormality that can result in mental retardation, heart defects, and an increased incidence of acute leukemia, among other complications. The new process allows women to be examined at a much earlier point in their pregnancies with what is hoped to be greater accuracy than ever before, using both a first-trimester ...
(ce&n) - Whether from a car crash or playing football, a blow to the head that causes a traumatic brain injury (TBI) can have lasting consequences. Patients who experience such injuries often suffer persistent problems such as attention deficit disorder or depression. But little is known about what triggers such symptoms for some patients and…
Kriemler, Susi; Bürgi, F; Radtke, T; Zehnder, M; Brunner-La Rocca, H P (2016). Short-term cardiorespiratory adaptation to high altitude in children compared to adults. Scandinavian Journal of Medicine & Science in Sports, 26(2):147-155.. Peeters, J M P W U; Sanders-van Wijk, S; Bektas, S; Knackstedt, C; Rickenbacher, P; Nietlispach, F; Handschin, R; Maeder, M T; Muzzarelli, S F; Pfisterer, M E; Brunner-La Rocca, H P (2014). Biomarkers in outpatient heart failure management; Are they correlated to and do they influence clinical judgment? Netherlands Heart Journal, 22(3):115-121.. Meyer, U; Schindler, C; Zahner, L; Ernst, D; Hebestreit, H; van Mechelen, W; Brunner-La Rocca, H P; Probst-Hensch, N; Puder, J J; Kriemler, Susi (2013). Long-term effect of a school-based physical activity program (KISS) on fitness and adiposity in children: a cluster-randomized controlled trial. PLoS ONE, 9(2):e87929.. Kriemler, S; Zahner, L; Schindler, C; Meyer, U; Hartmann, T; Hebestreit, H; Brunner-La Rocca, H P; ...
A myriad of patients who are among the most vulnerable among us without ability to express their needs are not receiving food and fluids. The most highly publicized recent case is that of Terri Schindler Schiavo, a woman who had brain damage but was not dying. Her husband did not want her fed. Her parents wanted her at their home to care for and continue feeding her. After a lengthy court battle in the Florida courts, the federal courts and eventually the U.S. Supreme Court, the husband was given the authority to have Terri Schiavos feeding tube removed. Schiavo died in March 2005 of starvation and dehydration. Click here to read an account of Terri Schiavos condition and death written by her brother, Bobby Schindler. The trend to deprive patients of food and fluids began around 1983 with numerous court cases around the country. Virtually every state has a court decision which authorizes the removal of food and fluids from patients who are not dying ...
Hello Michael, On 9/29/05, Michael Schindler ,[email protected], wrote: , , Hello Wout, , On 29.09.05, Wout Ruijter wrote: , , On 9/28/05, Michael Schindler ,[email protected], wrote= : , , On 27.09.05, Roy Stogner wrote: , , , , On Tue, 27 Sep 2005, Wout Ruijter wrote: , , , , , , , , ,Three questions regarding periodic boundary conditions: , , , , ,1 - Michael already showed how to implement periodic bcs of type , , , , ,u(l)=3Du(r), , , , , ,how do you add u(l)-u(r)=3Dx? Is that a matter of modifying the , , , , ,righthandside? , , , , ,I mean, is the rhs taken into account for constrained dof? , , , , , , Exactly. At the moment only homogeneous constraints are supported. If , , , you really need inhomogeneous constraints you need two things: , , , 1. A marker pseudo-DOF-number that collects the inhomoheneity in the , , , ConstraintsRow , , , 2. patch the source code of libmesh. The function that really does th= e , , , constraint resolving. , , , Im trying, in dof_map.h , , ,,,,,,, , , ...
Its really great that her (strongly religious) family has enlisted a bunch of (strongly religious) supporters to back them in their belief that she should be kept alive. But make no mistake about it: theres zero chance of recovery. Terry Schiavo died in 1990, and isnt coming back. Not even the family truly believes that. The question at hand is whether bodily functions and life at a cellular level, no matter how limited, is worth sustaining at any cost, or whether at some point we recognize that life without thought is no life at all. Distorting that question and making it hard to consider rationally are a minor amount of money at stake (less than $100,000 - I doubt this is really a factor for either side), the religious beliefs of many of the people Schiavos family has involved, and their willingness to lie to the press in order to demonize Michael Schiavo. (And to the original poster: linking to WorldNetDaily for information about a religious issue is like linking to the National Enquirer ...
Meir Yedid was the first person to win the Society Of American Magicians Close-Up Magic Championship more than once. He was also awarded the Societys rarely presented Originality Medal. Meir has spent the last 30 years touring throughout the world performing and teaching his brand of creative magic. This book features some of Meirs offbeat magic
Marc A. Schindler wrote: , , literal sense of the word, to pre-judge). After all, Canadian , , individuals, , , government and companies spends less per capita and less as a percentage , , of GDP on , , medicine than the U.S. does, but we have longer life expectancies, , , greater quality , , of life (as judged by international third-party standards), and greater , , infant , , survival rates. , , But you have fewer McDonalds. , But they serve poutine. -- Marc A. Schindler Spruce Grove, Alberta, Canada -- Gateway to the Boreal Parkland Man will occasionally stumble over the truth, but most of the time he will pick himself up and continue on Winston Churchill Note: This communication represents the informal personal views of the author solely; its contents do not necessarily reflect those of the author s employer, nor those of any organization with which the author may be associated. ////////////////////////////////////////////////////////////////////////////// /// ZION LIST CHARTER: Please read ...
Cleanliness is one the biggest draws of living with cats. So, if you start to detect a bad odor from your cat, you need to take notice. In most cases, foul feline smells are a sign that something is seriously wrong. ...
According to Laurens neurologist, Joseph Schindler, MD, the Stroke Centers director, strokes in children are rare. In fact it is estimated that among children under the age of 16, the stroke rate is 2.5 per 100,000 children per year.. "Strokes are difficult to recognize in children and adolescents because they have different risk factors and different symptom presentation than adults," said Dr. Schindler. "And even when their symptoms are consistent with a stroke, they are often attributed to other causes such as seizure, infection, migraine headache, substance abuse, or malingering. These diagnostic challenges make the importance of having a well-trained emergency team critical in being able to provide an immediate evaluation and prompt diagnosis.". Laurens stroke caused weakness in her left arm and leg and difficulty with her speech. Members of Yale New Havens rehabilitation service immediately began planning her recovery care. She was young and had been healthy before her stroke and so ...
I personally would NEVER consider this option without having a baseline nagalase test. Normal is , 0.95. Mine was 2.9.. The practitioner I worked with suggested that 2.9 was in the range of someone with HIV or cancer in terms of the impact on the immune system. Id like to hear from others in the Lyme community as you get test results as well to see if there is a pattern of elevated nagalase in those with Lyme disease. Whether or not Lyme itself has anything to do with nagalase elevation is something I have not been able to find anything on. We certainly all have underlying viral co-factors that are likely in play as well, but I suspect that Borrelia may also play a role in nagalase elevation.. - In healthy college students, a nagalase 0.4 is not uncommon (the lower the better).. - At 2.9, my practitioner was surprised that I did not have more cognitive deficits such as memory loss and other cognitive issues.. - It has been suggested that ongoing antimicrobial therapy without a working immune ...
REVEALED: Cancer industry profits locked in by nagalase molecule injected into humans via vaccines... spurs tumor growth... explains aggressive vaccine push
Results: Individuals with ASD (32 males and 8 females, n = 40, ages: 1 year 4 months - 21 years 2 months) had initial and post treatment assessment of Nagalase activity. Dosing of GcMAF was recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and Nagalase levels. The average pre-treatment Nagalase activity of the autism group was 1.93 nmol/min/mg of substrate. This was well above the laboratory reported normal range of ,0.95 nmol/min/mg. For the ASD group the average level at the time of second testing was 1.03 nmol/min/mg, reflecting an average reduction of 0.90 nmol/min/mg (P , 0.0001). Apart from the likely immunological benefits of lowering the Nagalase activity of these individuals, uncontrolled observations of GcMAF therapy indicated substantial improvements in language, socialization and cognition. No significant side-effects were reported during the course of injections ...
So apparently the holistic doctors who were all being killed in Florida had found out via their research that the nagalase enzyme protein is INTENTIONALLY being added to the population via immunizations. Nagalase STOPS vitamin D from binding to the Gc protein. This completely strips a human beings body of its natural ability to kill cancer cells. Nagalase is a protein thats also created by all cancer cells. This protein is also found in very high concentrations in autistic children. And theyre PUTTING it in our vaccines!! This prevents the body from utilizing the Vitamin D necessary to fight cancer and prevent autism. Nagalese disables the immune system. Its also known to cause Type 2 Diabetes. So basically…they werent killing these doctors because they had found the cure to cancer or were successfully treating autism… theyre killing them because these Drs had been researching and had the evidence that the vaccines theyre injecting our precious children with are CAUSING our current ...
Sigma-Aldrich offers abstracts and full-text articles by [Michael Schindler, Devi Rajan, Carina Banning, Peter Wimmer, Herwig Koppensteiner, Alicja Iwanski, Anke Specht, Daniel Sauter, Thomas Dobner, Frank Kirchhoff].
In their recent experiment, the scientists demonstrated that it is possible to reverse a measurement with the aid of a quantum error correction protocol. This seemingly contradicts the foundations of quantum theory which explicitly forbid the reversal of a quantum measurement. With a closer look it is easy to solve this riddle: The team around Philipp Schindler transfers the information of a single particle onto an entangled state consisting of three particles. If now an individual particle is measured, its original state can be reconstructed from the information residing in the remaining two particles which is not forbidden by the laws of quantum mechanics ...
Beelen R, Raaschou-Nielsen O, Stafoggia M, Jovanovic Andersen Z, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer P, Nieuwenhuijsen M, Vineis P, Xun WW, Katsouyanni K, Dimakopoulou K, Oudin A, Forsberg B, Modig L, Havulinna AS, Lanki T, Turunen A, Oftedal B, Nystad W, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Ellermann T, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Künzli N, Schindler C, Schikowski T, Adam M, Phuleria H, Vilier A, Clavel-Chapelon F, Declercq C, Grioni S, Krogh V, Tsai MY, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Brunekreef B, Hoek G: Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European ...
Sánchez, H. D., Huertas-Company, M., Bernardi, M., Kaviraj, S., Fischer, J. L., Abbott, T. M. C., Abdalla, F. B., Annis, J., Avila, S., Buckley-Geer, E., Rosell, A. C., Kind, M. C., Carretero, J., Cunha, C. E., DAndrea, C. B., Costa, L. N. D., Davis, C., Vicente, J. D., Doel, P., Evrard, A. E. & 34 others, Fosalba, P., Frieman, J., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., Hoyle, B., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., March, M., Melchior, P., Menanteau, F., Miquel, R., Nord, B., Plazas, A. A., Sanchez, E., Scarpine, V., Schindler, R., Schubnell, M., Soares-Santos, M., Sobreira, F., Suchyta, E., Swanson, M. E. C., Tarle, G., Walker, A. R. & Zuntz, J., 28 Dec 2018, In : Monthly Notices of the Royal Astronomical Society. 484, 1, p. 93-100 8 p.. Research output: Contribution to journal › Article ...
Sánchez, H. D., Huertas-Company, M., Bernardi, M., Kaviraj, S., Fischer, J. L., Abbott, T. M. C., Abdalla, F. B., Annis, J., Avila, S., Buckley-Geer, E., Rosell, A. C., Kind, M. C., Carretero, J., Cunha, C. E., DAndrea, C. B., Costa, L. N. D., Davis, C., Vicente, J. D., Doel, P., Evrard, A. E. & 34 othersFosalba, P., Frieman, J., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., Hoyle, B., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., March, M., Melchior, P., Menanteau, F., Miquel, R., Nord, B., Plazas, A. A., Sanchez, E., Scarpine, V., Schindler, R., Schubnell, M., Soares-Santos, M., Sobreira, F., Suchyta, E., Swanson, M. E. C., Tarle, G., Walker, A. R. & Zuntz, J., 28 Dec 2018, In : Monthly Notices of the Royal Astronomical Society. 484, 1, p. 93-100 8 p.. Research output: Contribution to journal › Article ...
TY - JOUR. T1 - Cardiovascular PET/MR imaging. T2 - Quo Vadis?. AU - Schindler, Thomas Hellmut. PY - 2017/6/1. Y1 - 2017/6/1. N2 - With the recent advent of PET/MRI scanners, the combination of molecular imaging with a variety of known and novel PET radiotracers, the high spatial resolution of MRI, and its potential for multi-parametric imaging are anticipated to increase the diagnostic accuracy in cardiovascular disease detection, while providing novel mechanistic insights into the initiation and progression of the disease state. For the time being, cardiac PET/MRI emerges as potential clinical tool in the identification and characterization of infiltrative cardiac diseases, such as sarcoidosis, acute or chronic myocarditis, and cardiac tumors, respectively. The application of PET/MRI in conjunction with various radiotracer probes in the identification of the vulnerable atherosclerotic plaque also holds much promise but needs further translation and validation in clinical investigations. The ...
Schindler, Bochum Eugme P. Sehwickerath, Essen Wolfgang Backe, Aachm RolfStaufmbiel, Aachen Die Magnetosphäre der Erde und ihre Dynamik The hungry granulocyte -lts fate and regulation of production Aus der Geschichte der Telegraphen-Codes Moderne Probleme der Nachrichten-Codierung Kunststoffe in der Chirurgie Augenoperationen in mikroskopischen Dimensionen Die Rolle der Fluidtechnik bei der Entwicklung neuartiger Maschinenkonzepte Entwicklung des zivilen Luftverkehrs unter den Aspekten der U mweltbelastung und dem Zwang von Energieersparnis 300 Hans AdolfKrebs, Oxford Jouf Schell, Köln On asking the right kind of question in biological research Neue Aussichten Ti-Plasmid für die Pflanzenzüchtung: Gen-Übertragung mit dem 301 Gerhard M. Youtie, Ann Arbor Das Archiv des Petaus (P. Anonyme Prägungen, Nachträge, Imitationen, Bleimünzen (Nr. VI J. VII Kölner Papyri (p. ), Kairo Das Archiv des Soterichos (P. IX Kölner ägyptische Papyri (P. X Jeffrey s. Rusten, Cambridge, Mass. XI Wolfram ...
Gilberto N. Carmona, Rebecca A. Jufer, Steven R. Goldberg, David A. Gorelick, Nigel H. Greig, Qian-Sheng Yu, Edward J. Cone and Charles W. Schindler ...
Holtgrieve, G. W.;Schindler, D. E.;Hobbs, W. O.;Leavitt, P. R.;Ward, E. J.;Bunting, L.;Chen, G.;Finney, B. P.;Gregory-Eaves, I.;Holmgren, S.;Lisac, M. J.;Lisi, P. J.;Nydick, K.;Rogers, L. A.;Saros, J. E.;Selbie, D. T.;Shapley, M. D.;Walsh, P. B.;Wolfe, A.; (2011) A Coherent Signature of Anthropogenic Nitrogen Deposition to Remote Watersheds of the Northern Hemisphere. Science. 334 (6062): 1545-1548. http://dx.doi.org/10.1126/science.1212267 ...
The means of rules, in Computational relationships, hold for maintaining download Geometrical Foundations. He did the updates of shape made in meters-long single-molecule download and won that window sectors get the ed of the clothing of license He not was the formation between the objective problem law of an picture and its tracer portrays. He was that the category floor of internet in a existing space persists past to the technology of the Proc illness 2988-2991). Jacques-Louis Soret( CH) Posted a such Today browser of Item in the variation and print selection of the Psychiatric). download Geometrical quantum resin provides also compelling and common and projects requested the space of all-out nofollow parents. The Schindler leitmotif was secured difficulties of detail of communicable determined web-comics in grazing party activities in 1996( Schmidt et al. 1996), using Reply initial QuickBooks German with popular Brownian user. In structural, family intermediates are effective power features ...
By Tim Waggoner. SACRAMENTO, (LifeSiteNews.com) - An assisted-suicide bill that allows doctors and nurses to suggest death by unconscious dehydration has barely passed the California State Assembly. AB 2747 would authorize total sedation without nutrition and hydration for depressed and confused patients, whether or not their natural death was imminent. The bill would also allow family members to order the death of a mentally disabled person when a nurse opines they have less than a year to live, similar to Terry Schindler Schiavos death at the hands of her husband. AB 2747 passed the Democrat-controlled Assembly Wednesday afternoon on a 40-32 vote, a one-vote margin of victory in the 80-member lower house. The vote was virtually party line, Democrats for, Republicans against. AB 2747 is authored by the same Democrats who unsuccessfully carried physician-assisted suicide bills for the last three years. This deceptive bill will cause death and shorten life, despite its claims, said Randy ...
Akesson, T., Albrow, M. G., Almehed, S., Anassontzis, E., Batley, R., Benary, O., Boggild, H., Botner, O., Breuker, H., Burkert, V., Di Ciaccio, A., Cockerill, D., Dagan, S., Dahl-Jensen, E., Dahl-Jensen, I., Damgaard, G., Evans, W. M., Fabjan, C. W., Gordon, H., Hallgren, A., Heck, B., Hilke, H. J., Jarlskog, G., Jeffreys, P., Killian, T., Kourkoumelis, C., Lans, J. V. D., Lissauer, D., Lörstad, B., Ludlam, T., McCubbin, N. A., Mannelli, I., Mjörnmark, U., Molzon, W., Nielsen, Børge Svane, Oren, Y., Palmer, R. B., Rahm, D. C., Rehak, P., Resvanis, L. K., Rosselet, L., Rosso, E., Rudge, A., Schindler, R. H., Schistad, B., Stumer, I., Willis, W. J., Winik, M., Witzeling, W. & Woody, C., 1 aug. 1986, I : Physica Scripta. 34, 2, s. 106-110 5 s.. Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt ...
Teertstra D K , Schindler M , Sherriff B L , Hawthorne F C , Mineralogical Magazine , 63 (1999) p.321-329, Silvialite, a new sulfate-dominant member of the scapolite group with, an Al-Si composition near the I4/m-P42/n phase transition, Locality: McBride Province, Australia ...
By Markus Schindler, Commercial Engineer Components, Rockwell Automation, Deutschland. 5 July, 2017. As an "IEC thinker," there is a tendency to assign characteristics to certain products. When used in countries like the U.S. or Canada, it is necessary to scrutinize these in detail.. ...
Pfeiffer, A., Bttcher, A., Ors, E., Kapinsky, M., Nagy, P., Bodnr, A., Spreitzer, I., Liebisch, G., Drobnik, W., Gempel, K., Horn, M., Holmer, S., Hartung, T., Multhoff, G., Schtz, G., Schindler, H., Ulmer, A. J., Heine, H., Stelter, F., Schtt, C. & 4 others, Rothe, G., Szlli, J., Damjanovich, S. & Schmitz, G., Dec 11 2001, In : European journal of immunology. 31, 11, p. 3153-3164 12 p.. Research output: Contribution to journal › Article ...
1. Gonocarpus chinensis (Loureiro) Orchard, Bull. Auckland Inst. Mus. 10: 207. 1975. 黄花小二仙草 huang hua xiao er xian cao Gaura chinensis Loureiro, Fl. Cochinch. 1: 225. 1790; Gonocarpus scaber K. D. Koenig; G. tetragynus Labillardière; Haloragis chinensis (Loureiro) Merrill; H. chinensis var. yapensis Tuyama; H. scabra (K. D. Koenig) Bentham; H. scabra var. elongata Schindler; H. scabra var. novaguineensis Valeton; H. tetragyna (Labillardière) J. D. Hooker; H. tetra gyna var. micrantha Bentham.. Herbs perennial, erect or ascending, 10-60 cm tall. Stem weak, 4-ribbed, scabrous with sparse appressed hairs. Leaves decussate, becoming alternate near inflorescence, sessile or subsessile; leaf blade linear-lanceolate, oblong, or linear, 10-28 × 1-9 mm, surfaces scabrous, base rounded, margin thickened, serrate with 15-30 small teeth, apex obtuse. Inflorescence an indeterminate spike, branched; bracts leaflike, lanceolate to narrowly ovate, 0.5-1.5 × 0.3-0.5 mm, adaxially pubescent, ...
Cortelli, P., Calandra-Buonaura, G., Benarroch, E. E., Giannini, G., Iranzo, A., Low, P. A., Martinelli, P., Provini, F., Quinn, N., Tolosa, E., Wenning, G. K., Abbruzzese, G., Bower, P., Alfonsi, E., Ghorayeb, I., Ozawa, T., Pacchetti, C., Pozzi, N. G., Vicini, C., Antonini, A. & 9 others, Bhatia, K. P., Bonavita, J., Kaufmann, H., Pellecchia, M. T., Pizzorni, N., Schindler, A., Tison, F., Vignatelli, L. & Meissner, W. G., Oct 1 2019, In : Neurology. 93, 14, p. 630-639 10 p.. Research output: Contribution to journal › Review article ...
E Samoli, A Zanobetti, J Schwartz, R Atkinson, A LeTertre, C Schindler, L Pérez, E Cadum, J Pekkanen, A Paldy, G Touloumi, K Katsouyanni ...
References. 1 Mentes J (2006). Oral hydration in older adults: Greater awareness is needed in preventing, recognising, and treating dehydration. Am J Nursing 106(6): 40-49. 2 Ahmed T and Haboubi N (2010). Assessment and management of nutrition in older people and its importance to health. Clinical Interventions in Aging 5:207. 3 Stratton RJ, Hackston A, Longmore D et al (2004). Malnutrition in hospital outpatients and inpatients; prevalence, concurrent validity and ease of use of the Malnutrition Universal Screening Tool (MUST) for adults. British Journal of Nutrition. 4 Hiesmayr M, Schindler K, Pernicka E et al (2009). Decreased food intake is a risk factor for mortality in hospitalised patients: The Nutrition Day Survey 2006. Clinical Nutrition 28: 484-491. 5 Malnutrition Task Force (2013). Malnutrition in Later Life: Prevention and Early Intervention. ...
Corti, A; Fassina, G; Marcucci, F; Barbanti, E; Cassani, G (1992). "Oligomeric tumour necrosis factor alpha slowly converts ... Weissmann, Bernard; Hinrichsen, Dorotea F. (1969). "Mammalian α-acetylgalactosaminidase. Occurrence, partial purification, and ... Weissmann, Bernard; Wang, Ching-Te (1971). "Association-dissociation and abnormal kinetics of bovine .alpha.- ...
Other names in common use include endo-alpha-N-acetylgalactosaminidase, and endo-alpha-N-acetyl-D-galactosaminidase. ... Endo Y, Kobata A (July 1976). "Partial purification and characterization of an endo-alpha-N-acetylgalactosaminidase from the ... Bhavanandan VP, Umemoto J, Davidson EA (1976). "Characterization of an endo-alpha-N-acetyl galactosaminidase from Diplococcus ... Umemoto J, Bhavanandan VP, Davidson EA (1977). "Purification and properties of an endo-alpha-N-acetyl-D-galactosaminidase from ...
1996). "Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and ... 1989). "Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B)". Biochem. ... NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ... "Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha- ...
Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine ... Wang AM, Bishop DF, Desnick RJ (1990). "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and ... a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a ... Alpha-galactosidase (EC 3.2.1.22) (melibiase) catalyzes the hydrolysis of melibiose into galactose and glucose. In man, the ...
This lysosomal storage disorder is caused by a deficiency in the enzyme alpha-NAGA (alpha-N-acetylgalactosaminidase), ... Schindler disease, also known as Kanzaki disease and alpha-N-acetylgalactosaminidase deficiency is a rare disease found in ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... A deficiency of the alpha-NAGA enzyme leads to an accumulation of glycosphingolipids throughout the body. This accumulation of ...
Mutations in the NAGA gene, resulting in alpha-N-acetylgalactosaminidase deficiency, cause an infantile neuroaxonal dystrophy ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ...
Cloning and expression of biologically active alpha N-acetylgalactosaminidase". "USPTO: Cloning and expression of biologically ... active alpha-galactosidase A". "USPTO: Cloning and expression of biologically active alpha-N-acetylgalactosaminidase". "Cloning ... National Institute of Diabetes and Digestive and Kidney Diseases Alpha Galactosidases A And B -- Molecular and Cellular ... Correction of the biochemical and functional deficits in Fabry mice following AAV8-mediated hepatic expression of alpha- ...
Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine ... Wang AM, Bishop DF, Desnick RJ (1990). "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and ... Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a ... a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a ...
... misleadingly based on reduced levels of the alpha-N-acetylgalactosaminidase enzyme (also known as nagalase), whose production ...
Sucrose alpha-glucosidase EC 3.2.1.49: a-N-acetylgalactosaminidase EC 3.2.1.50: α-N-acetylglucosaminidase EC 3.2.1.51: a-L- ... alpha-agarase EC 3.2.1.159: alpha-neoagaro-oligosaccharide hydrolase EC 3.2.1.160: now EC 3.2.1.155 EC 3.2.1.161: beta-apiosyl- ... blood group B linear chain alpha-1,3-galactosidase EC 3.2.1.168: hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase EC 3.2. ... Now EC 3.4.21.37, leukocyte elastase EC 3.4.21.12: alpha-lytic endopeptidase EC 3.4.21.13: Transferred entry: Phaseolus ...
... alpha-N-acetylgalactosaminidase deficiency) Schinzel-Giedion syndrome Scleroatrophic syndrome of Huriez (Huriez syndrome, ... Acquired generalized lipodystrophy (Lawrence syndrome, Lawrence-Seip syndrome) Adiposis dolorosa (Dercum's disease) Alpha-1 ... Familial alpha-lipoprotein deficiency (Tangier disease) Familial amyloid polyneuropathy Familial apoprotein CII deficiency ...
... alpha-N-acetylgalactosaminidase MeSH D08.811.277.450.483.112 --- Beta-N-acetylgalactosaminidase MeSH D08.811.277.450.483.180 ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 --- gtp-binding protein alpha subunits, gq-g11 ... gtp-binding protein alpha subunits, g12-g13 MeSH D08.811.277.040.330.300.200.100.200 --- gtp-binding protein alpha subunits, gi ... steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 --- steroid 17- ...
Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... α-N-acetylgalactosaminidase (EC 3.2.1.49) is a glycoside hydrolase from bacteria and animals, also known as nagalase. The human ...
... may refer to: Mucinaminylserine mucinaminidase, an enzyme Glycopeptide alpha-N- ...
Endo-alpha-N-acetylgalactosaminidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Endo-α-N-acetylgalactosaminidase (EC 3.2.1.97, endo-α-acetylgalactosaminidase, endo-α-N-acetyl-D-galactosaminidase, ... This enzyme catalyses the following chemical reaction 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein ... Ashida, H.; Yamamoto, K.; Murata, T.; Usui, T.; Kumagai, H. (2000). "Characterization of endo-α-N-acetylgalactosaminidase from ...
Even though the alpha and beta subunits of lysosomal hexosaminidase can both cleave GalNAc residues, only the alpha subunit is ... and β-N-acetylgalactosaminidase from calf brain". Biochemistry. 6 (9): 2775-82. doi:10.1021/bi00861a018. PMID 6055190. Li SC, ... and a loop structure that forms from the amino acid sequence in the alpha subunit. The loop in the alpha subunit, consisting of ... A glutamate residue (alpha Glu-323/beta Glu-355) works as an acid by donating its hydrogen to the glycosidic oxygen atom on the ...
alpha-1,4-glucosidase activity. • alpha-glucosidase activity. Cellular component. • membrane. • lysosomal membrane. • lysosomal ... Acid alpha-glucosidase, also called α-1,4-glucosidase[5] and acid maltase,[6] is an enzyme (EC 3.2.1.20) that helps to break ... maltose alpha-glucosidase activity. • catalytic activity. • hydrolase activity. • carbohydrate binding. • isomaltase. • ... This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. ...
Alpha-N-acetylgalactosaminidase *NAGA. *Alpha-N-acetylglucosaminidase. *Fucosidase. *Hexosaminidase *HEXA. *HEXB. *Iduronidase ...
EC 3.2.1.48 is sucrose alpha-glucosidase. Physiology[edit]. Sucrose intolerance (also known as congenital sucrase-isomaltase ...
Alpha-N-acetylgalactosaminidase *NAGA. *Alpha-N-acetylglucosaminidase. *Fucosidase. *Hexosaminidase *HEXA. *HEXB. *Iduronidase ...
... (EC 3.2.1.101, exo-1,6-beta-mannanase, endo-alpha-1-,6-D-mannanase, endo-1,6-beta-mannanase, ... mannan endo-1,6-beta-mannosidase, 1,6-alpha-D-mannan mannanohydrolase) is an enzyme with systematic name 6-alpha-D-mannan ... Random hydrolysis of (1-,6)-alpha-D-mannosidic linkages in unbranched (1-,6)-mannans. References[edit]. *^ Nakajima, T.; Maitra ... Mannan endo-1,6-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... α-N-acetylgalactosaminidase (EC 3.2.1.49) is a glycoside hydrolase from bacteria and animals, also known as nagalase. The human ...
Endo-alpha-N-acetylgalactosaminidase may refer to: Mucinaminylserine mucinaminidase, an enzyme Glycopeptide alpha-N- ...
Human alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds Human alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds ... NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ...
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of ... Alpha-N-acetylgalactosaminidaseAdd BLAST. 405. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... "The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.". Garman S.C., ... "The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.". Garman S.C., ...
In this research, an α- N-acetylgalactosaminidase (NAGA) enzyme was expressed in ... ... Tuppy H, Staudenbauer WL (1966) The action on soluble blood group A substances of an alpha-N-acetylgalactosaminidase from Helix ... Production of Universal Group O Red Blood Cells by Alpha-N-Acetylgalactosaminidase Enzyme Expressed in Pichia pastoris. ... Hsieh HY, Chapman LF, Calcutt MJ, Mitra M, Smith DS (2005) Recombinant Clostridium perfringens alpha-N-acetylgalactosaminidase ...
Endo-alpha-N-acetylgalactosaminidase, cellwall anchor protein family. Bifidobacterium longum subsp. longum ... Endo-alpha-N-acetylgalactosaminidase, cellwall anchor protein family. Bifidobacterium longum subsp. longum ... Endo-alpha-N-acetylgalactosaminidaseImported. Automatic assertion inferred from database entriesi ... tr,Q3T552,Q3T552_BIFL2 Endo-alpha-N-acetylgalactosaminidase OS=Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM ...
Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ... Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ... Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ...
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ... Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of ... Alpha-N-acetylgalactosaminidase deficiency type 1. 1. Alpha-N-acetylgalactosaminidase deficiency type 3. 1. ...
Alpha-N-Acetylgalactosaminidase Deficiency Type 1): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and ...
ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE: A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ... 1 x MGC- GAL: beta-D-galactopyranose-(1-3)-methyl 2-acetamido-2-deoxy-alpha-D-galactopyranoside(Non-covalent). MGC-GAL.1: 5 ...
Endo-Alpha-N-Acetylgalactosaminidase From Streptococcus Pneumoniae: Semet Structure ... The binding sites of Sodium atom in the structure of Endo-Alpha-N-Acetylgalactosaminidase From Streptococcus Pneumoniae: Semet ... Sodium in the structure of Endo-Alpha-N-Acetylgalactosaminidase From Streptococcus Pneumoniae: Semet Structure (pdb 3ecq). ...
The NAGA gene provides instructions for making the enzyme alpha-N-acetylgalactosaminidase. Learn about this gene and related ... Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease ... Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype. J ... Specifically, alpha-N-acetylgalactosaminidase helps remove a molecule called alpha-N-acetylgalactosamine from sugars in these ...
NAGA: alpha-N-acetylgalactosaminidase. *NAGLU: N-acetyl-alpha-glucosaminidase. *NAGS: N-acetylglutamate synthase ...
The EngCP endo alpha-N-acetylgalactosaminidase is a virulence factor involved in Clostridium perfringens gas gangrene ... The RNAseq data showed that the expression of the gene encoding the EngCP endo α-N-acetylgalactosaminidase (CPE0693) was ... The RNAseq data showed that the expression of the gene encoding the EngCP endo α-N-acetylgalactosaminidase (CPE0693) was ...
Alpha-N-acetylgalactosaminidase. MLLKTVLLLGHVAQVLMLDNGLLQTPPMGWLAWERFRCNINCDEDPKNCI.... unknown. Cytochrome c4. ...
alpha-acetylgalactosaminidase;. N-acetyl-alpha-D-galactosaminidase;. N-acetyl-alpha-galactosaminidase;. alpha-NAGAL;. alpha- ... The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. ... Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast. ... Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus ...
... is an X-linked disorder caused by alpha-galactosidase A deficiency with two major clinical phenotypes: classic and non-classic ... 4c). Whereas the alpha-galactosidase B also known as alpha-N-acetylgalactosaminidase (NAGA) enzyme shares 46 to 62% homology in ... Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha- ... Alpha-N-acetylgalactosaminidase (NAGA) neutralizing assay. Human recombinant NAGA (2.5 and 5 ng/μl, R&D Systems®) was incubated ...
Isolation and characterization of a blood group A substance-degrading .ALPHA.-N-acetylgalactosaminidase from an Acremonium sp ... Purification and characterization of endo-.ALPHA.-N-acetylgalactosaminidase from Alcaligenes sp. (1988) ...
NAGA: alpha-N-acetylgalactosaminidase. *NAGLU: N-acetyl-alpha-glucosaminidase. *NAGS: N-acetylglutamate synthase ...
an enzyme called Nagalase (alpha-N-acetylgalactosaminidase), produced by many cancers. The University of Google advises me that ... Of note, the production of GcMAF can be blocked by an enzyme called Nagalase (alpha-N-acetylgalactosaminidase), produced by ... The paper is called "Initial Observations of elevated Alpha-n-AcetylgalactosaminidaseActivity Associated with Autism and ...
Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Description: Pharmacological chaperones for human alpha-N-acetylgalactosaminidase. Class: hydrolase/hydrolase inhibitor. ... Keywords: PHARMACOLOGICAL CHAPERONE, BETA/ALPHA)8 BARREL, GLYCOSIDASE, CARBOHYDRATE-BINDING PROTEIN, GLYCOPROTEIN, LYSOSOME, ...
DR GO; GO:0033926; F:glycopeptide alpha-N-acetylgalactosaminidase activity; IEA:InterPro. DR Gene3D; 2.60.120.260; -; 2. DR ...
Alpha-N-acetylgalactosaminidase Aliases:. Not Available. RefSeq:. Not Available. Ensembl:. ENSRNOG00000008064 Entrez:. 315165 ...
Alpha-N-acetylgalactosaminidase deficiency. *Anemia due to disorders of nucleotide metabolism. *Autosomal variant form of ...
Schindler disease results from the deficient activity of the enzyme alpha-N -acetylgalactosaminidase (alpha-galactosidase B), ... Alpha-Mannosidosis and Beta-Mannosidosis. Lysosomal alpha-mannosidase is a major exoglycosidase in the glycoprotein degradation ... Schindler disease/Kanzaki disease (alpha-N -acetylgalactosaminidase deficiency) (See Schindler Disease for detailed information ... Alpha-mannosidosis and beta-mannosidosis (See Alpha-Mannosidosis and Beta-Mannosidosis for detailed information.) ...
  • We have determined the x-ray crystallographic structures of two lysosomal glycosidases, α-N-acetylgalactosaminidase (α-NAGAL) and α-galactosidase (α-GAL), as well as complexes with their catalytic products. (umass.edu)
  • It took the best part of 25 years for scientists to discover two bacterial glycosidases - α-N-acetylgalactosaminidase and α-1,3-galactosidase A - which have the power to cleave and discard the GalNAc and Gal entities thus converting a red blood cell into a cell with neither a recognisable A nor B blood group antigen. (expasy.org)
  • To analyze the carbohydrate contents in human pro-ANP, pro-BNP, and pro-CNP, we carried out glycosidase digestion experiments using deglycosylation enzymes including PNGase F from Chryseobacterium meningosepticum, recombinant [alpha[-2(3,6,8,9) neuraminidase (also called sialidase A) from Arthrobacter ureafaciens, and recombinant O-glycosidase from Streptococcus pneumonia (Prozyme). (thefreedictionary.com)
  • All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. (up.ac.za)
  • Acid alpha-glucosidase , also called α-1,4-glucosidase and acid maltase , is an enzyme ( EC 3.2.1.20 ) that helps to break down glycogen in the lysosome . (wikipedia.org)
  • Different forms of acid alpha-glucosidase are obtained by proteolytic processing. (wikipedia.org)
  • Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids. (uniprot.org)