alpha-N-Acetylgalactosaminidase: A hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.Hexosaminidases: Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.Macrophage-Activating Factors: Factors secreted by stimulated lymphocytes that prime macrophages to become nonspecifically cytotoxic to tumors. They also modulate the expression of macrophage cell surface Ia antigens. One MAF is INTERFERON-GAMMA. Other factors antigenically distinct from IFN-gamma have also been identified.Fucosidosis: An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS; GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)alpha-Galactosidase: An enzyme that catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-galactosides including galactose oligosaccharides, galactomannans, and galactolipids.Vitamin D-Binding Protein: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.Fabry Disease: An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.Bacillales: An order of gram-positive bacteria in the class Bacilli, phylum Firmicutes.Paenibacillus: A genus of GRAM-POSITIVE ENDOSPORE-FORMING RODS in the family Paenibacillaceae.Gram-Positive Endospore-Forming Bacteria: Bacteria that form endospores and are gram-positive. Representative genera include BACILLUS; CLOSTRIDIUM; MICROMONOSPORA; SACCHAROPOLYSPORA; and STREPTOMYCES.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Burkholderiaceae: A family of gram negative, aerobic, non-sporeforming, rod-shaped bacteria.Anoxybacillus: A genus of GRAM-POSITIVE ENDOSPORE-FORMING BACTERIA in the family Bacillaceae. Most species have been isolated from HOT SPRINGS.Genome, Bacterial: The genetic complement of a BACTERIA as represented in its DNA.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Hot Springs: Habitat of hot water naturally heated by underlying geologic processes. Surface hot springs have been used for BALNEOLOGY. Underwater hot springs are called HYDROTHERMAL VENTS.International Classification of Diseases: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Clinical Coding: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)Insurance Claim Review: Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.United StatesInsurance Claim Reporting: The design, completion, and filing of forms with the insurer.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Medical Records: Recording of pertinent information concerning patient's illness or illnesses.Patient Discharge: The administrative process of discharging the patient, alive or dead, from hospitals or other health facilities.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Sialoglycoproteins: Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.Sialic Acids: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.Glycophorin: The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.MNSs Blood-Group System: A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)Sialic Acid Binding Immunoglobulin-like Lectins: A family of SIALIC ACID binding proteins found in vertebrate species. They are transmembrane proteins which act as cell surface receptors for a variety of sialylated GLYCOCONJUGATES. While a subset of siglec protein subtypes are evolutionarily conserved between mammalian species, there are many others that are species specific.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Periodic Acid: A strong oxidizing agent.Maackia: A plant genus of the family FABACEAE. It contains a hemagglutinin.Neuraminidase: An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)Neuroaxonal Dystrophies: A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)Group VI Phospholipases A2: A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodeling and homeostasis by controling the levels of PHOSPHATIDYLCHOLINE in mammalian cell membranes.Forehead: The part of the face above the eyes.Abnormalities, MultipleAxons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Head Movements: Voluntary or involuntary motion of head that may be relative to or independent of body; includes animals and humans.Surgery, Veterinary: A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)Surgery, Plastic: The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.1-Deoxynojirimycin: An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.Imino Sugars: Sugars in which the OXYGEN is replaced by a NITROGEN atom. This substitution prevents normal METABOLISM resulting in inhibition of GLYCOSIDASES and GLYCOSYLTRANSFERASES.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

The extracellular matrix in the mouse brain: its reactions to endo-alpha-N-acetylgalactosaminidase and certain other enzymes. (1/59)

As our previous studies have indicated, the cingulate cortex of the adult mouse brain contains many neurons with rich cell surface glycoproteins which are linked by collagenous ligands to perineuronal proteoglycans. The present study demonstrated that exclusive incubation with endo-alpha-N-acetylgalactosaminidase abolished the lectin Vicia villosa or Wisteria floribunda agglutinin (VVA or WFA) labeling of the nerve cell surface glycoproteins, while it neither interfered with the cationic iron colloid or aldehyde fuchsin stainings of the perineuronal proteoglycans nor abolished the Gomori's ammoniacal silver impregnation of the collagenous ligands. Double incubations with endo-alpha-N-acetylgalactosaminidase and collagenase did not eliminate the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, though they did eliminate the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans as well as the Gomori's ammoniacal silver impregnation of the collagenous ligands. Triple incubations with endo-alpha-N-acetylgalactosaminidase, collagenase, and endo-alpha-N-acetylgalactosaminidase abolished the lectin VVA or WFA labeling of the nerve cell surface glycoproteins, and also eliminated the cationic iron colloid and aldehyde fuchsin stainings of the perineuronal proteoglycans and the Gomori's ammoniacal silver impregnation of the collagenous ligands. These findings indicate that: the nerve cell surface glycoproteins or their terminal N-acetylgalactosamines are digested by endo-alpha-N-acetylgalactosaminidase; these galactosamines associated with the collagenous ligands or perineuronal proteoglycans are not digested by endo-alpha-N-acetylgalactosaminidase; and the terminal N-acetylgalactosamines newly exposed by collagenase incubation are digested by this galactosaminidase. It was further demonstrated that hyaluronidase incubation neither digests the collagenous ligands nor revives the lectin VVA or WFA labeling of the nerve cell surface proteoglycans.  (+info)

Glycoprotein lysosomal storage disorders: alpha- and beta-mannosidosis, fucosidosis and alpha-N-acetylgalactosaminidase deficiency. (2/59)

Glycoproteinoses belong to the lysosomal storage disorders group. The common feature of these diseases is the deficiency of a lysosomal protein that is part of glycan catabolism. Most of the lysosomal enzymes involved in the hydrolysis of glycoprotein carbohydrate chains are exo-glycosidases, which stepwise remove terminal monosaccharides. Thus, the deficiency of a single enzyme causes the blockage of the entire pathway and induces a storage of incompletely degraded substances inside the lysosome. Different mutations may be observed in a single disease and in all cases account for the nonexpression of lysosomal glycosidase activity. Different clinical phenotypes generally characterize a specific disorder, which rather must be described as a continuum in severity, suggesting that other biochemical or environmental factors influence the course of the disease. This review provides details on clinical features, genotype-phenotype correlations, enzymology and biochemical storage of four human glycoprotein lysosomal storage disorders, respectively alpha- and beta-mannosidosis, fucosidosis and alpha-N-acetylgalactosaminidase deficiency. Moreover, several animal disorders of glycoprotein metabolism have been found and constitute valuable models for the understanding of their human counterparts.  (+info)

Human alpha-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides. (3/59)

Human alpha-N-acetylgalactosaminidase (alpha-GalNAc; also known as alpha-galactosidase B) is the lysosomal exoglycohydrolase that cleaves alpha-N-acetylgalactosaminyl moieties in glycoconjugates. Mutagenesis studies indicated that the first five (N124, N177, N201, N359, and N385) of the six potential N-glycosylation sites were occupied. Site 3 occupancy was important for enzyme function and stability. Characterization of the N-linked oligosaccharide structures on the secreted enzyme overexpressed in Chinese hamster ovary cells revealed highly heterogeneous structures consisting of complex (approximately 53%), hybrid (approximately 12%), and high mannose-type (approximately 33%) oligosaccharides. The complex structures were mono-, bi-, 2,4-tri-, 2,6-tri-, and tetraantennary, among which the biantennary structures were most predominant (approximately 53%). Approximately 80% of the complex oligo-saccharides had a core-region fucose and 50% of the complex oligosaccharides were sialylated exclusively with alpha-2,3-linked sialic acid residues. The majority of hybrid type oligo-saccharides were GalGlcNAcMan(6)GlcNAc-Fuc(0-1)GlcNAc. Approximately 54% of the hybrid oligosaccharide were phosphorylated and one-third of these structures were further sialylated, the latter representing unique phosphorylated and sialylated structures. Of the high mannose oligosaccharides, Man(5-7)GlcNAc(2) were the predominant species (approximately 90%) and about 50% of the high mannose oligosaccharides were phosphorylated, exclusively as monoesters whose positions were determined. Comparison of the oligosaccharide structures of alpha-GalNAc and alpha-galactosidase A, an evolutionary-related and highly homologous exoglycosidase, indicated that alpha-GalNAc had more completed complex chains, presumably due to differences in enzyme structure/domains, rate of biosynthesis, and/or aggregation of the overexpressed recombinant enzymes.  (+info)

Blood group A antigen is a coreceptor in Plasmodium falciparum rosetting. (4/59)

The malaria parasite Plasmodium falciparum utilizes molecules present on the surface of uninfected red blood cells (RBC) for rosette formation, and a dependency on ABO antigens has been previously shown. In this study, the antirosetting effect of immune sera was related to the blood group of the infected human host. Sera from malaria-immune blood group A (or B) individuals were less prone to disrupt rosettes from clinical isolates of blood group A (or B) patients than to disrupt rosettes from isolates of blood group O patients. All fresh clinical isolates and laboratory strains exhibited distinct ABO blood group preferences, indicating that utilization of blood group antigens is a general feature of P. falciparum rosetting. Soluble A antigen strongly inhibited rosette formation when the parasite was cultivated in A RBC, while inhibition by glycosaminoglycans decreased. Furthermore, a soluble A antigen conjugate bound to the cell surface of parasitized RBC. Selective enzymatic digestion of blood group A antigen from the uninfected RBC surfaces totally abolished the preference of the parasite to form rosettes with these RBC, but rosettes could still form. Altogether, present data suggest an important role for A and B antigens as coreceptors in P. falciparum rosetting.  (+info)

Adhesion of human lung mast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism. (5/59)

Mast cells contribute to the pathophysiology of asthma through their immunomediator-secretory activity in response to both immunological and nonimmunological stimuli, and infiltrate the bronchial epithelium in this disease. We hypothesized that human lung mast cells (HLMC) localize to the bronchial epithelium via a specific cell-cell adhesion mechanism. We investigated the adhesion of HLMC to primary bronchial epithelial cells and the bronchial epithelial cell line BEAS-2B. HLMC adhered avidly to both primary cultures of bronchial epithelial cells and BEAS-2B cells (mean adhesion 68.4 and 60.1%, respectively) compared with eosinophil adhesion to BEAS-2B (mean adhesion 10.3%). HLMC adhesion did not alter after epithelial activation with cytokines, did not require Ca2+, and was not integrin-mediated. IgE-dependent activation of HLMC produced an approximately 40% inhibition of adhesion. There was significant attenuation of adhesion after incubation of HLMC with pronase, beta-galactosidase, and endo-alpha-N-acetylgalactosaminidase, indicating that HLMC adhere to bronchial epithelial cells via galactose-bearing carbohydrates expressed on a cell-surface peptide(s).  (+info)

Trypsin inhibitory activity of bovine fetuin de-O-glycosylated by endo-alpha-N-acetylgalactosaminidase. (6/59)

The effects of bovine fetuin O-glycans on its trypsin inhibitory activity were examined. De-sialylated (asialo-) and de-O-glycosylated fetuin were prepared from native fetuin using Arthrobacter neuraminidase and the mixture of it and Bacillus endo-alpha-N-acetylgalactosaminidase, respectively. De-sialylation and de-O-glycosylation from fetuin were confirmed with SDS-PAGE followed by western blotting using anti-human Thomsen-Friedenreich antigen (T antigen) antibody which recognizes O-linked galactosyl beta1,3 N-acetylgalactosamine (Gal beta1-->3GalNAc). Native fetuin completely inhibited the trypsin activity at about a 1:1 molar ratio. In contrast, the trypsin inhibitory activity of asialo- and de-O-glycosylated fetuin decreased about a half and one-third of that of native fetuin, respectively.  (+info)

Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: no association with neuroaxonal dystrophy? (7/59)

Two new individuals with alpha-NAGA deficiency are presented. The index patient, 3 years old, has congenital cataract, slight motor retardation and secondary demyelinisation. Screening of his sibs revealed an alpha-NAGA deficiency in his 7-year-old healthy brother who had no clinical or neurological symptoms. Both sibs are homozygous for the E325K mutation, the same genotype that was found in the most severe form of alpha-NAGA deficiency presenting as infantile neuroaxonal dystrophy. Thus, at the age of 7 years the same genotype of alpha-NAGA may present as a 'non-disease' (present healthy case) and can be associated with the vegetative state (the first two patients described with alpha-NAGA deficiency). The clinical heterogeneity among the 11 known individuals with alpha-NAGA deficiency is extreme, with a 'non-disease' (two cases) and infantile neuroaxonal dystrophy (two cases) at the opposite sides of the clinical spectrum. The broad spectrum is completed by a very heterogeneous group of patients with various degrees of epilepsy/behavioural difficulties/psychomotor retardation (four patients) and a mild phenotype in adults without overt neurological manifestations who have angiokeratoma and clear vacuolisation in various cell types (three cases). These observations are difficult to reconcile with a straightforward genotype-phenotype correlation and suggest that factors or genes other than alpha-NAGA contribute to the clinical heterogeneity of the 11 patients with alpha-NAGA deficiency.  (+info)

Efficient synthesis of O-linked glycopeptide by a transglycosylation using endo alpha-N-acetylgalactosaminidase from Streptomyces sp. (8/59)

Gal beta-(1-->3)-GalNAc-linked hexapeptide was synthesized by a transglycosylation using Gal beta-(1-->3)-GalNAc beta-pNP as a donor and a serine-containing hexapeptide as an acceptor using endo GalNAc-ase from Streptomyces sp.. The Gal beta-(1-->3)-GalNAc residue was transferred to the hydroxyl group of the serine residue of the peptide. The total yield of the glycopeptide via this process was better than that of the chemoenzymatic method. This process was confirmed to be a versatile method for the synthesis of O-linked glycopeptides.  (+info)

*Alpha-N-acetylgalactosaminidase

Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... α-N-acetylgalactosaminidase (EC 3.2.1.49) is a glycoside hydrolase from bacteria and animals, also known as nagalase. The human ...

*Endo-alpha-N-acetylgalactosaminidase

... may refer to: Mucinaminylserine mucinaminidase, an enzyme Glycopeptide alpha-N- ...

*Glycopeptide alpha-N-acetylgalactosaminidase

Endo-alpha-N-acetylgalactosaminidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Endo-α-N-acetylgalactosaminidase (EC 3.2.1.97, endo-α-acetylgalactosaminidase, endo-α-N-acetyl-D-galactosaminidase, ... This enzyme catalyses the following chemical reaction 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein ... Ashida, H.; Yamamoto, K.; Murata, T.; Usui, T.; Kumagai, H. (2000). "Characterization of endo-α-N-acetylgalactosaminidase from ...

*Mucinaminylserine mucinaminidase

Other names in common use include endo-alpha-N-acetylgalactosaminidase, and endo-alpha-N-acetyl-D-galactosaminidase. ... Endo Y, Kobata A (July 1976). "Partial purification and characterization of an endo-alpha-N-acetylgalactosaminidase from the ... Bhavanandan VP, Umemoto J, Davidson EA (1976). "Characterization of an endo-alpha-N-acetyl galactosaminidase from Diplococcus ... Umemoto J, Bhavanandan VP, Davidson EA (1977). "Purification and properties of an endo-alpha-N-acetyl-D-galactosaminidase from ...

*NAGA (gene)

1996). "Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and ... 1989). "Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B)". Biochem. ... NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ... "Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha- ...

*Schindler disease

This lysosomal storage disorder is caused by a deficiency in the enzyme alpha-NAGA (alpha-N-acetylgalactosaminidase), ... Schindler disease, also known as Kanzaki disease and alpha-N-acetylgalactosaminidase deficiency is a rare disease found in ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... A deficiency of the alpha-NAGA enzyme leads to an accumulation of glycosphingolipids throughout the body. This accumulation of ...

*Infantile neuroaxonal dystrophy

Mutations in the NAGA gene, resulting in alpha-N-acetylgalactosaminidase deficiency, cause an infantile neuroaxonal dystrophy ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ...

*Glycoside hydrolase family 27

Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine ... Wang AM, Bishop DF, Desnick RJ (1990). "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and ... a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a ... Alpha-galactosidase (EC 3.2.1.22) (melibiase) catalyzes the hydrolysis of melibiose into galactose and glucose. In man, the ...

*Glycoside hydrolase family 36

Alpha-N-acetylgalactosaminidase (EC 3.2.1.49) catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine ... Wang AM, Bishop DF, Desnick RJ (1990). "Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and ... Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a ... a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a ...

*GcMAF

... misleadingly based on reduced levels of the alpha-N-acetylgalactosaminidase enzyme (also known as nagalase), whose production ...

*List of cutaneous conditions

... alpha-N-acetylgalactosaminidase deficiency) Schinzel-Giedion syndrome Scleroatrophic syndrome of Huriez (Huriez syndrome, ... Acquired generalized lipodystrophy (Lawrence syndrome, Lawrence-Seip syndrome) Adiposis dolorosa (Dercum's disease) Alpha-1 ... Familial alpha-lipoprotein deficiency (Tangier disease) Familial amyloid polyneuropathy Familial apoprotein CII deficiency ...

*List of MeSH codes (D08)

... alpha-N-acetylgalactosaminidase MeSH D08.811.277.450.483.112 --- Beta-N-acetylgalactosaminidase MeSH D08.811.277.450.483.180 ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 --- gtp-binding protein alpha subunits, gq-g11 ... gtp-binding protein alpha subunits, g12-g13 MeSH D08.811.277.040.330.300.200.100.200 --- gtp-binding protein alpha subunits, gi ... steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 --- steroid 17- ...

*Morpheein

Corti, A; Fassina, G; Marcucci, F; Barbanti, E; Cassani, G (1992). "Oligomeric tumour necrosis factor alpha slowly converts ... Weissmann, Bernard; Hinrichsen, Dorotea F. (1969). "Mammalian α-acetylgalactosaminidase. Occurrence, partial purification, and ... Weissmann, Bernard; Wang, Ching-Te (1971). "Association-dissociation and abnormal kinetics of bovine .alpha.- ...

*Robert J. Desnick

Cloning and expression of biologically active alpha N-acetylgalactosaminidase". "USPTO: Cloning and expression of biologically ... active alpha-galactosidase A". "USPTO: Cloning and expression of biologically active alpha-N-acetylgalactosaminidase". "Cloning ... National Institute of Diabetes and Digestive and Kidney Diseases Alpha Galactosidases A And B -- Molecular and Cellular ... Correction of the biochemical and functional deficits in Fabry mice following AAV8-mediated hepatic expression of alpha- ...

*List of EC numbers (EC 3)

Sucrose alpha-glucosidase EC 3.2.1.49: a-N-acetylgalactosaminidase EC 3.2.1.50: α-N-acetylglucosaminidase EC 3.2.1.51: a-L- ... alpha-agarase EC 3.2.1.159: alpha-neoagaro-oligosaccharide hydrolase EC 3.2.1.160: now EC 3.2.1.155 EC 3.2.1.161: beta-apiosyl- ... blood group B linear chain alpha-1,3-galactosidase EC 3.2.1.168: hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase EC 3.2. ... Now EC 3.4.21.37, leukocyte elastase EC 3.4.21.12: alpha-lytic endopeptidase EC 3.4.21.13: Transferred entry: Phaseolus ...

*Hexosaminidase

Even though the alpha and beta subunits of lysosomal hexosaminidase can both cleave GalNAc residues, only the alpha subunit is ... and β-N-acetylgalactosaminidase from calf brain". Biochemistry. 6 (9): 2775-82. doi:10.1021/bi00861a018. PMID 6055190. Li SC, ... and a loop structure that forms from the amino acid sequence in the alpha subunit. The loop in the alpha subunit, consisting of ... A glutamate residue (alpha Glu-323/beta Glu-355) works as an acid by donating its hydrogen to the glycosidic oxygen atom on the ...
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
Not many students can list a prestigious journal as the publication where their first academic research paper appeared, but such is the case for Schindler. Co-authored with his supervisor Gabriel Comita, his research using the calorimeter to determine the energy content of small aquatic organisms including copepods, algae, and crayfish, was published in Science in 1963. Publishing for the very first time in one of the worlds premier science journals was perhaps to foreshadow the prominent role of the science Schindler has researched and published throughout his continuing career.. Schindlers PhD studies focused on lakes from an ecosystem perspective, studying initially with Nikko Tinbergen and then Charles Elton. Following completion of his PhD at Oxford, Schindler headed to Trent University in the small town of Peterborough, Ontario, a setting that appealed to Schindler because of its geological diversity and the many surrounding lakes. During his first year at Trent, Schindler learned about ...
Alpha-N-acetylgalactosaminidase (NAGA) deficiency is a very rare lysosomal storage disorder. It is clinically heterogeneous with 3 main phenotypes: type I is an infantile-onset neuroaxonal dystrophy; type II, also known as Kanzaki disease ({609242}), is an adult-onset disorder characterized by angiokeratoma corporis diffusum and mild intellectual impairment; and type III is an intermediate disorder with mild to moderate neurologic manifestations ({3:Desnick and Schindler, 2001 ...
Clark, NE, Garman, SC. The 1.9 A structure of human alpha-N-acetylgalactosaminidase: The structural basis of Schindler and Kanzaki diseases. Journal of Molecular Biology. 2009, Oct 23;393(2):435-447. [PubMed]. Ishii S, Chang HH, Kawasaki K, Yasuda K, Wu HL, Garman SC, Fan JQ. Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical characterization and restoration of normal intracellular processing by 1-deoxygalactonojirimycin. Biochem J. 2007 Sep 1;406(2):285-95.[PubMed]. Hebert DN, Garman SC, Molinari M. (2005) "The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags." Trends Cell Biol. Jul;15(7):364-70. Review.[PubMed]. Su HP, Garman SC, Allison TJ, Fogg C, Moss B, Garboczi DN. (2005) "The 1.51-Angstrom structure of the poxvirus L1 protein, a target of potent neutralizing antibodies." Proc Natl Acad Sci U S A. Mar 22;102(12):4240-5. Epub 2005 Mar 10. [PubMed]. Ries ...
Eze, Ikenna C; Foraster, Maria; Schaffner, Emmanuel; Vienneau, Danielle; Héritier, Harris; Rudzik, Franziska; Thiesse, Laurie; Pieren, Reto; Imboden, Medea; von Eckardstein, Arnold; Schindler, Christian; Brink, Mark; Cajochen, Christian; Wunderli, Jean-Marc; Röösli, Martin; Probst-Hensch, Nicole (2017). Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study. International Journal of Epidemiology, 46(4):1115-1125.. Boillat-Blanco, Noémie; Bovet, Pascal; Ramaiya, Kaushik L; Mganga, Maliwasa; Minja, Lilian T; Saleh, Lanja; Imboden, Medea; Schindler, Christian; Gagneux, Sebastien; Daubenberger, Claudia; Reither, Klaus; Probst-Hensch, Nicole (2016). Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study. BMC Infectious Diseases, 16(1):626.. Eze, Ikenna C; Imboden, Medea; Kumar, Ashish; von Eckardstein, Arnold; Stolz, Daiana; Gerbase, Margaret W; Künzli, Nino; Pons, Marco; ...
Serum Gc protein (known as vitamin D3-binding protein) is the precursor for the principal macrophage activating factor (MAF). The MAF precursor activity of serum Gc protein of HIV-infected patients was lost or reduced because Gc protein is deglycosylated by alpha-N-acetylgalactosaminidase (Nagalase) secreted from HIV-infected cells. Therefore, macrophages of HIV-infected patients having deglycosylated Gc protein cannot be activated, leading to immunosuppression. Since Nagalase is the intrinsic component of the envelope protein gp120, serum Nagalase activity is the sum of enzyme activities carried by both HIV virions and envelope proteins. These Nagalase carriers were already complexed with anti-HIV immunoglobulin G (IgG) but retained Nagalase activity that is required for infectivity. Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage activating factor (termed GcMAF), which produces no side effects in humans. ...
In 2014, Dr. Tom deTar raised close to $27,000 for the Anna Schindler Foundation in his successful bid to complete the 2014 IRONMAN CDA. He blew past all expectations and his dedication and charity have already helped the Foundation carry out its mission of supporting kids with cancer.. In 2015, nine athletes competed in the IRONMAN for Anna race, June 28th, raising over $31,000 for childhood cancer families. In 2016, 11 athletes did the IM CDA 70.3 & 140.6 raising $19,000 for our cause.. ...
Chesapeake Life Center invites the community to the 11th annual Emily Schindler Memorial Lecture titled The Trauma Whisperers: What Works in Contemporary Trauma Treatment presented by Daniel L. Buccino, LCSW-C, BCD, from 9 a.m. to 12:15 p.m. Wednesday, May 25, 2016, at Anne Arundel Community College, 7000 Arundel
Free Essays from Bartleby | When Schindler finally realized the true cruelty of the Holocaust, his once selfish nature shifted into one of complete...
Holly Schindler is the author of three previous YA novels: PLAYING HURT as well as the critically acclaimed FERAL (starred PW review) and A BLUE SO DARK (starred Booklist review, ForeWord Book of the Year silver medal, IPPY gold medal). A writer of books for all ages, Schindlers MG, THE JUNCTION OF SUNSHINE AND LUCKY, has made the master list for childrens book awards in Illinois, South Carolina, and Alabama. She is also a hybrid author, having independently released comedic womens fiction (FIFTH AVENUE FIDOS) and the forthcoming PLAY IT AGAIN, her adult follow-up to her YA PLAYING HURT. She can be reached through her author site: hollyschindler.com, and hosts special sneak peeks and giveaways for subscribers of her newsletter: tinyletter.com/hollyschindler.com. ...
Bobby Schindler, Terris brother, told WorldNetDaily Schiavo is distorting the conversation that triggered the rift between the Schindlers and the Schiavos. My father was seeking money for Terris rehabilitation, which Michael Schiavo was refusing to give her, he said, calling Schiavos accusation ironic. In June of 1993, eight months after he got the malpractice money, he tried to kill Terri by withholding antibiotics needed to treat an infection. There was $800,000 in the fund at the time, Bobby Schindler said. According to court records, the caregivers at the nursing home overruled Schiavos order and treated Terri for her infection. As additional proof that hes not in the legal battle for the money, Schiavo told King he offered three times to donate the money to charity two years ago. But Bobby Schindler called it a hollow offer. The offer came with the stipulation that my parents agree to let my sister starve to death. Why would we let her starve to death?, Schindler told ...
for a Schindler, this was very nice. Traction, very fast Facebook: http://www.facebook.com/dieselducy Website: http://www.dieselducy.com Google+: http://www....
Studies are reported on Alpha-Galactosidase and Conversion of Group B Erythrocytes and (2) Isolation and Characterization of Alpha-N-Acetylgalactosaminidase.*Enzymes
Recently approved by the U.S. Food and Drug Administration, VenaSeal is a minimally invasive procedure that permanently treats varicose veins located close to the surface of the skin. "Unlike previous treatment options, VenaSeal involves fewer injections along the length of the leg and is less painful," explained Dr. Schindler, who holds an academic appointment at the University of Chicago Pritzker School of Medicine.. During the outpatient procedure, Dr. Schindler inserts a catheter through the skin and injects a small amount of medical glue to seal off the abnormal vein, restoring normal blood flow. "In Pats case, we were able to perform the VenaSeal procedure on both legs during the same appointment, which isnt always possible with other treatment options," added Dr. Schindler.. "It was unbelievable how much better I felt right away," exclaimed Kelley. "Now my pain is gone and my energy level is back to normal. Im so grateful to my NorthShore physicians who were so reassuring. I just cant ...
Itoh, T., Ochiai, A., Mikami, B., Hashimoto, W. and Murata, K. (2006). "A novel glycoside hydrolase family 105: the structure of family 105 unsaturated rhamnogalacturonyl hydrolase complexed with a disaccharide in comparison with family 88 enzyme complexed with the disaccharide". J. Mol. Biol. 360: 573-585. PMID 16781735. ...
Pregnancy is a time of anticipation. And for many parents, its also a time of worry, mostly over the health of the unborn child. But Bostons medical establishment is on the cutting edge of advances that can allay expectant parents fears over the congenital abnormalities and diseases that can be passed down to new generations. No test yet exists to screen for all problems, but there are a few specific exams that parents can now utilize. For example, a new procedure to check for Down syndrome is being tried at the New England Medical Center, part of a national study sponsored by the National Institutes of Health.. Down syndrome is a congenital disorder caused by a chromosome abnormality that can result in mental retardation, heart defects, and an increased incidence of acute leukemia, among other complications. The new process allows women to be examined at a much earlier point in their pregnancies with what is hoped to be greater accuracy than ever before, using both a first-trimester ...
Kriemler, Susi; Bürgi, F; Radtke, T; Zehnder, M; Brunner-La Rocca, H P (2016). Short-term cardiorespiratory adaptation to high altitude in children compared to adults. Scandinavian Journal of Medicine & Science in Sports, 26(2):147-155.. Peeters, J M P W U; Sanders-van Wijk, S; Bektas, S; Knackstedt, C; Rickenbacher, P; Nietlispach, F; Handschin, R; Maeder, M T; Muzzarelli, S F; Pfisterer, M E; Brunner-La Rocca, H P (2014). Biomarkers in outpatient heart failure management; Are they correlated to and do they influence clinical judgment? Netherlands Heart Journal, 22(3):115-121.. Meyer, U; Schindler, C; Zahner, L; Ernst, D; Hebestreit, H; van Mechelen, W; Brunner-La Rocca, H P; Probst-Hensch, N; Puder, J J; Kriemler, Susi (2013). Long-term effect of a school-based physical activity program (KISS) on fitness and adiposity in children: a cluster-randomized controlled trial. PLoS ONE, 9(2):e87929.. Kriemler, S; Zahner, L; Schindler, C; Meyer, U; Hartmann, T; Hebestreit, H; Brunner-La Rocca, H P; ...
A myriad of patients who are among the most vulnerable among us without ability to express their needs are not receiving food and fluids. The most highly publicized recent case is that of Terri Schindler Schiavo, a woman who had brain damage but was not dying. Her husband did not want her fed. Her parents wanted her at their home to care for and continue feeding her. After a lengthy court battle in the Florida courts, the federal courts and eventually the U.S. Supreme Court, the husband was given the authority to have Terri Schiavos feeding tube removed. Schiavo died in March 2005 of starvation and dehydration. Click here to read an account of Terri Schiavos condition and death written by her brother, Bobby Schindler. The trend to deprive patients of food and fluids began around 1983 with numerous court cases around the country. Virtually every state has a court decision which authorizes the removal of food and fluids from patients who are not dying ...
Hello Michael, On 9/29/05, Michael Schindler ,[email protected], wrote: , , Hello Wout, , On 29.09.05, Wout Ruijter wrote: , , On 9/28/05, Michael Schindler ,[email protected], wrote= : , , On 27.09.05, Roy Stogner wrote: , , , , On Tue, 27 Sep 2005, Wout Ruijter wrote: , , , , , , , , ,Three questions regarding periodic boundary conditions: , , , , ,1 - Michael already showed how to implement periodic bcs of type , , , , ,u(l)=3Du(r), , , , , ,how do you add u(l)-u(r)=3Dx? Is that a matter of modifying the , , , , ,righthandside? , , , , ,I mean, is the rhs taken into account for constrained dof? , , , , , , Exactly. At the moment only homogeneous constraints are supported. If , , , you really need inhomogeneous constraints you need two things: , , , 1. A marker pseudo-DOF-number that collects the inhomoheneity in the , , , ConstraintsRow , , , 2. patch the source code of libmesh. The function that really does th= e , , , constraint resolving. , , , Im trying, in dof_map.h , , ,,,,,,, , , ...
Its really great that her (strongly religious) family has enlisted a bunch of (strongly religious) supporters to back them in their belief that she should be kept alive. But make no mistake about it: theres zero chance of recovery. Terry Schiavo died in 1990, and isnt coming back. Not even the family truly believes that. The question at hand is whether bodily functions and life at a cellular level, no matter how limited, is worth sustaining at any cost, or whether at some point we recognize that life without thought is no life at all. Distorting that question and making it hard to consider rationally are a minor amount of money at stake (less than $100,000 - I doubt this is really a factor for either side), the religious beliefs of many of the people Schiavos family has involved, and their willingness to lie to the press in order to demonize Michael Schiavo. (And to the original poster: linking to WorldNetDaily for information about a religious issue is like linking to the National Enquirer ...
Marc A. Schindler wrote: , , literal sense of the word, to pre-judge). After all, Canadian , , individuals, , , government and companies spends less per capita and less as a percentage , , of GDP on , , medicine than the U.S. does, but we have longer life expectancies, , , greater quality , , of life (as judged by international third-party standards), and greater , , infant , , survival rates. , , But you have fewer McDonalds. , But they serve poutine. -- Marc A. Schindler Spruce Grove, Alberta, Canada -- Gateway to the Boreal Parkland Man will occasionally stumble over the truth, but most of the time he will pick himself up and continue on Winston Churchill Note: This communication represents the informal personal views of the author solely; its contents do not necessarily reflect those of the author s employer, nor those of any organization with which the author may be associated. ////////////////////////////////////////////////////////////////////////////// /// ZION LIST CHARTER: Please read ...
Cleanliness is one the biggest draws of living with cats. So, if you start to detect a bad odor from your cat, you need to take notice. In most cases, foul feline smells are a sign that something is seriously wrong. ...
Meir Yedid was the first person to win the Society Of American Magicians Close-Up Magic Championship more than once. He was also awarded the Societys rarely presented Originality Medal. Meir has spent the last 30 years touring throughout the world performing and teaching his brand of creative magic. This book features some of Meirs offbeat magic
Like a stealth bomber, the Nagalase enzyme synthesized in and released from a cancer cell or a virus particle pinpoints the GcMAF production facilities on the surface of your T and B lymphocytes and then wipes them out with an incredibly precise bomb. How precise? Let me put it this way: Nagalase locates and attacks one specific two-electron bond located at, and only at, the 420th amino acid position on a huge protein molecule (DBP), one of tens of thousands of proteins, each containing millions of electrons. This is like selectively taking out a park bench in a major city from six thousand miles away. More astonishing, if that is possible, Nagalase never misses its target. There is no collateral damage.. GcMAF is a cell-signaling glycoprotein that talks to macrophages, enabling them to rapidly find, attack, and kill viruses and cancer cells. By activating macrophages, GcMAF triggers a cascade that activates the entire immune system. Blockage of GcMAF production by Nagalase brings all this ...
Results: Individuals with ASD (32 males and 8 females, n = 40, ages: 1 year 4 months - 21 years 2 months) had initial and post treatment assessment of Nagalase activity. Dosing of GcMAF was recommended based on previously reported response curves adjusted by the treating clinician for age, weight, and Nagalase levels. The average pre-treatment Nagalase activity of the autism group was 1.93 nmol/min/mg of substrate. This was well above the laboratory reported normal range of ,0.95 nmol/min/mg. For the ASD group the average level at the time of second testing was 1.03 nmol/min/mg, reflecting an average reduction of 0.90 nmol/min/mg (P , 0.0001). Apart from the likely immunological benefits of lowering the Nagalase activity of these individuals, uncontrolled observations of GcMAF therapy indicated substantial improvements in language, socialization and cognition. No significant side-effects were reported during the course of injections ...
So apparently the holistic doctors who were all being killed in Florida had found out via their research that the nagalase enzyme protein is INTENTIONALLY being added to the population via immunizations. Nagalase STOPS vitamin D from binding to the Gc protein. This completely strips a human beings body of its natural ability to kill cancer cells. Nagalase is a protein thats also created by all cancer cells. This protein is also found in very high concentrations in autistic children. And theyre PUTTING it in our vaccines!! This prevents the body from utilizing the Vitamin D necessary to fight cancer and prevent autism. Nagalese disables the immune system. Its also known to cause Type 2 Diabetes. So basically…they werent killing these doctors because they had found the cure to cancer or were successfully treating autism… theyre killing them because these Drs had been researching and had the evidence that the vaccines theyre injecting our precious children with are CAUSING our current ...
Sigma-Aldrich offers abstracts and full-text articles by [Michael Schindler, Devi Rajan, Carina Banning, Peter Wimmer, Herwig Koppensteiner, Alicja Iwanski, Anke Specht, Daniel Sauter, Thomas Dobner, Frank Kirchhoff].
In their recent experiment, the scientists demonstrated that it is possible to reverse a measurement with the aid of a quantum error correction protocol. This seemingly contradicts the foundations of quantum theory which explicitly forbid the reversal of a quantum measurement. With a closer look it is easy to solve this riddle: The team around Philipp Schindler transfers the information of a single particle onto an entangled state consisting of three particles. If now an individual particle is measured, its original state can be reconstructed from the information residing in the remaining two particles which is not forbidden by the laws of quantum mechanics ...
Sánchez, H. D., Huertas-Company, M., Bernardi, M., Kaviraj, S., Fischer, J. L., Abbott, T. M. C., Abdalla, F. B., Annis, J., Avila, S., Buckley-Geer, E., Rosell, A. C., Kind, M. C., Carretero, J., Cunha, C. E., DAndrea, C. B., Costa, L. N. D., Davis, C., Vicente, J. D., Doel, P., Evrard, A. E. & 34 othersFosalba, P., Frieman, J., García-Bellido, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hartley, W. G., Hollowood, D. L., Honscheid, K., Hoyle, B., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., March, M., Melchior, P., Menanteau, F., Miquel, R., Nord, B., Plazas, A. A., Sanchez, E., Scarpine, V., Schindler, R., Schubnell, M., Soares-Santos, M., Sobreira, F., Suchyta, E., Swanson, M. E. C., Tarle, G., Walker, A. R. & Zuntz, J., 28 Dec 2018, In : Monthly Notices of the Royal Astronomical Society. 484, 1, p. 93-100 8 p.. Research output: Contribution to journal › Article ...
Sigma-Aldrich offers abstracts and full-text articles by [Sandra Donkervoort, Ying Hu, Tanya Stojkovic, Nicol C Voermans, A Reghan Foley, Meganne E Leach, Jahannaz Dastgir, Véronique Bolduc, Thomas Cullup, Alix de Becdelièvre, Lin Yang, Hai Su, Katherine Meilleur, Alice B Schindler, Erik-Jan Kamsteeg, Pascale Richard, Russell J Butterfield, Thomas L Winder, Thomas O Crawford, Robert B Weiss, Francesco Muntoni, Valérie Allamand, Carsten G Bönnemann].
Schindler, Bochum Eugme P. Sehwickerath, Essen Wolfgang Backe, Aachm RolfStaufmbiel, Aachen Die Magnetosphäre der Erde und ihre Dynamik The hungry granulocyte -lts fate and regulation of production Aus der Geschichte der Telegraphen-Codes Moderne Probleme der Nachrichten-Codierung Kunststoffe in der Chirurgie Augenoperationen in mikroskopischen Dimensionen Die Rolle der Fluidtechnik bei der Entwicklung neuartiger Maschinenkonzepte Entwicklung des zivilen Luftverkehrs unter den Aspekten der U mweltbelastung und dem Zwang von Energieersparnis 300 Hans AdolfKrebs, Oxford Jouf Schell, Köln On asking the right kind of question in biological research Neue Aussichten Ti-Plasmid für die Pflanzenzüchtung: Gen-Übertragung mit dem 301 Gerhard M. Youtie, Ann Arbor Das Archiv des Petaus (P. Anonyme Prägungen, Nachträge, Imitationen, Bleimünzen (Nr. VI J. VII Kölner Papyri (p. ), Kairo Das Archiv des Soterichos (P. IX Kölner ägyptische Papyri (P. X Jeffrey s. Rusten, Cambridge, Mass. XI Wolfram ...
Gilberto N. Carmona, Rebecca A. Jufer, Steven R. Goldberg, David A. Gorelick, Nigel H. Greig, Qian-Sheng Yu, Edward J. Cone and Charles W. Schindler ...
Holtgrieve, G. W.;Schindler, D. E.;Hobbs, W. O.;Leavitt, P. R.;Ward, E. J.;Bunting, L.;Chen, G.;Finney, B. P.;Gregory-Eaves, I.;Holmgren, S.;Lisac, M. J.;Lisi, P. J.;Nydick, K.;Rogers, L. A.;Saros, J. E.;Selbie, D. T.;Shapley, M. D.;Walsh, P. B.;Wolfe, A.; (2011) A Coherent Signature of Anthropogenic Nitrogen Deposition to Remote Watersheds of the Northern Hemisphere. Science. 334 (6062): 1545-1548. http://dx.doi.org/10.1126/science.1212267 ...
J. Electron Spectrosc. Relat. Phenom. 79, 415-417 (1996) Hirschmugl, C.J., K.-M. Schindler, O. Schaff, V. Fernandez, A. Theobald, Ph. Hofmann, A.M. Bradshaw, R. Davis, N.A. Booth, D.P. Woodruff and V. Fritzsche ...
Surf. Sci. 307-309, 295-302 (1994) Davila, M.E., M.C. Asensio, D.P. Woodruff, K.-M. Schindler, Ph. Hofmann, K.-U. Weiss, R.Dippel, P. Gardner, V. Fritzsche, A.M. Bradshaw, J.C. Conesa and A.R. González-Elipe ...
The means of rules, in Computational relationships, hold for maintaining download Geometrical Foundations. He did the updates of shape made in meters-long single-molecule download and won that window sectors get the ed of the clothing of license He not was the formation between the objective problem law of an picture and its tracer portrays. He was that the category floor of internet in a existing space persists past to the technology of the Proc illness 2988-2991). Jacques-Louis Soret( CH) Posted a such Today browser of Item in the variation and print selection of the Psychiatric). download Geometrical quantum resin provides also compelling and common and projects requested the space of all-out nofollow parents. The Schindler leitmotif was secured difficulties of detail of communicable determined web-comics in grazing party activities in 1996( Schmidt et al. 1996), using Reply initial QuickBooks German with popular Brownian user. In structural, family intermediates are effective power features ...
By Tim Waggoner. SACRAMENTO, (LifeSiteNews.com) - An assisted-suicide bill that allows doctors and nurses to suggest death by unconscious dehydration has barely passed the California State Assembly. AB 2747 would authorize total sedation without nutrition and hydration for depressed and confused patients, whether or not their natural death was imminent. The bill would also allow family members to order the death of a mentally disabled person when a nurse opines they have less than a year to live, similar to Terry Schindler Schiavos death at the hands of her husband. AB 2747 passed the Democrat-controlled Assembly Wednesday afternoon on a 40-32 vote, a one-vote margin of victory in the 80-member lower house. The vote was virtually party line, Democrats for, Republicans against. AB 2747 is authored by the same Democrats who unsuccessfully carried physician-assisted suicide bills for the last three years. This deceptive bill will cause death and shorten life, despite its claims, said Randy ...
Teertstra D K , Schindler M , Sherriff B L , Hawthorne F C , Mineralogical Magazine , 63 (1999) p.321-329, Silvialite, a new sulfate-dominant member of the scapolite group with, an Al-Si composition near the I4/m-P42/n phase transition, Locality: McBride Province, Australia ...
By Markus Schindler, Commercial Engineer Components, Rockwell Automation, Deutschland. 5 July, 2017. As an "IEC thinker," there is a tendency to assign characteristics to certain products. When used in countries like the U.S. or Canada, it is necessary to scrutinize these in detail.. ...
1. Gonocarpus chinensis (Loureiro) Orchard, Bull. Auckland Inst. Mus. 10: 207. 1975. 黄花小二仙草 huang hua xiao er xian cao Gaura chinensis Loureiro, Fl. Cochinch. 1: 225. 1790; Gonocarpus scaber K. D. Koenig; G. tetragynus Labillardière; Haloragis chinensis (Loureiro) Merrill; H. chinensis var. yapensis Tuyama; H. scabra (K. D. Koenig) Bentham; H. scabra var. elongata Schindler; H. scabra var. novaguineensis Valeton; H. tetragyna (Labillardière) J. D. Hooker; H. tetra gyna var. micrantha Bentham.. Herbs perennial, erect or ascending, 10-60 cm tall. Stem weak, 4-ribbed, scabrous with sparse appressed hairs. Leaves decussate, becoming alternate near inflorescence, sessile or subsessile; leaf blade linear-lanceolate, oblong, or linear, 10-28 × 1-9 mm, surfaces scabrous, base rounded, margin thickened, serrate with 15-30 small teeth, apex obtuse. Inflorescence an indeterminate spike, branched; bracts leaflike, lanceolate to narrowly ovate, 0.5-1.5 × 0.3-0.5 mm, adaxially pubescent, ...
E Samoli, A Zanobetti, J Schwartz, R Atkinson, A LeTertre, C Schindler, L Pérez, E Cadum, J Pekkanen, A Paldy, G Touloumi, K Katsouyanni ...
References. 1 Mentes J (2006). Oral hydration in older adults: Greater awareness is needed in preventing, recognising, and treating dehydration. Am J Nursing 106(6): 40-49. 2 Ahmed T and Haboubi N (2010). Assessment and management of nutrition in older people and its importance to health. Clinical Interventions in Aging 5:207. 3 Stratton RJ, Hackston A, Longmore D et al (2004). Malnutrition in hospital outpatients and inpatients; prevalence, concurrent validity and ease of use of the Malnutrition Universal Screening Tool (MUST) for adults. British Journal of Nutrition. 4 Hiesmayr M, Schindler K, Pernicka E et al (2009). Decreased food intake is a risk factor for mortality in hospitalised patients: The Nutrition Day Survey 2006. Clinical Nutrition 28: 484-491. 5 Malnutrition Task Force (2013). Malnutrition in Later Life: Prevention and Early Intervention. ...
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, Décaillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W. Mol Cell. 2010 Mar 26;37(6):865-78.[http://tinyurl.com/2baghy7 ...
Timo Lanki, Regina Hampel, Pekka Tiittanen, Silke Andrich, Rob Beelen, Bert Brunekreef, Julia Dratva, Ulf De Faire, Kateryna B. Fuks, Barbara Hoffmann, Medea Imboden, Pekka Jousilahti, Wolfgang Koenig, Amir A. Mahabadi, Nino Künzli, Nancy L. Pedersen, Johanna Penell, Göran Pershagen, Nicole M. Probst-Hensch, Emmanuel Schaffner, Christian Schindler, Dorothea Sugiri, Wim J.R. Swart, Ming-Yi Tsai, Anu W. Turunen, Gudrun Weinmayr, Kathrin Wolf, Tarja Yli-Tuomi, and Annette Peters. ...
James Holm, executive producer of MSNBCs "AM Joy," is 45 ... ABCs MaryAlice Parks (h/t Arlette Saenz) ... Rep. Rob Wittman (R-Va.) is 58 ... Rep. Tom Graves (R-Ga.) is 47 ... Columbia 2L Janet Kanzawa, a Simpson Thacher & Bartlett alum (h/t Colby Bermel) ... RALLY principal/office volleyball captain Latia Curry and senior account executive and Mayor Villaraigosa alum Lys Mendez (h/ts Sam Garrett-Pate) ... Fox News contributor and fellow country music fan Lisa Marie Boothe, also president of High Noon Strategies (h/t Kurt Bardella) ... Rebecca Mark, a Cathy McMorris-Rodgers alum who just started as head of govt relations for Cruise Automation … Dana Thomas, former WaPo, Newsweek, and WSJ reporter, who recently made a state visit and was spotted at Cafe Milano (h/t Ben Chang) … Neal Carruth, GM of podcasting at NPR, is 41 ... Politicos Lisa Francis (h/t Rachel Schindler) ... Jonathan Lachman, former associate director for national security programs at OMB and a DOD alum ... CAP alum Tara ...
A Research Program to Examine Evidenced-Based Practices in Newborn Thermoregulation. M Schindler, C Herzner, I Berlet, S Dahlmann, F Loersch, and T Schaible, Universitätsklinikum Mannheim, Mannheim, Germany Lynn Lynam, GE Healthcare Perinatal, Laurel, MD, USA Petra Heep, GE Healthcare, Rodgau, Germany BACKGROUND: Thermoregulation is a critical component of neonatal care. Yet many of the practices surrounding thermoregulation have not been re-tested despite the fact that the frontier of viability has markedly changed over the last 4 decades. Maintaining a neutral thermal environment (NTE) whereby oxygen consumption is minimized for compromised newborns is one foundation of care for this population. Environmental temperatures impact mortality rates. There is no easy way to determine whether an infant is in his or her NTE. Rather clinicians have extrapolated data from historical studies that have determined the correlation between O2 consumption, rectal temperature, and skin temperature. The ...
Kohlert, C., Schindler, G., März, R., Abel, G., Brinkhaus, B., Derendorf, H., Gräfe, E. and Veit, M. (2002). Systemic Availability and Pharmacokinetics of Thymol in Humans. The Journal of Clinical Pharmacology, 42(7), pp.731-737 ...
The microgram amounts of PAHs per gram of sample detected in the new study are lower than those found in urbanized areas, which are impacted by vehicle emissions and coal power plants, Schindler explains. "But it is clear that if tighter controls on PAH emissions are not imposed, the lake sediments will be approaching Canadian guidelines for toxicity soon," he says.. ...
There are many famous Oscars throughout history -- flamboyant Irish writer Oscar Wilde, heroic German list-maker Oskar Schindler, and messy TV roommate Oscar Madison. But the one your child will relate to most is that shiny award they hand out to movie stars once a year.. ...
By RON WORD PINELLAS PARK, Fla. (AP) - With time running out for Terri Schiavo, a federal appeals court Wednesday rejected her parents latest attempt to get the brain-damaged womans feeding tube reconnected. The Atlanta-based 11th U.S. Circuit Court of Appeals agreed to consider an emergency bid by Bob and Mary Schindler for a new hearing in their case, raising a flicker of hope for the parents after a series of setbacks in the case. But the court rejected the bid 15 hours later - the fourth time since last week the court ruled against the Schindlers. Any further action by our court or the district court would be improper, wrote Judge Stanley F. Birch Jr., who was appointed by former President Bush. While the members of her family and the members of Congress have acted in a way that is both fervent and sincere, the time has come for dispassionate discharge of duty. Birch went on to scold President Bush and Congress for their attempts to intervene in the judicial process, by saying: In ...
Interview with Stephan Schindler, one of our Judges at Tech Rally 2017, CEO of Wonderlamp and founder of Virtual Reality e.V. Berlin Brandenburg - organizing VR NOW CON - about the Industry and the opportunities of VR.. 1. You joined Wonderlamp Industries in 2014 as CEO. What achievements are you most proud of thus far in your Tenure? What are you currently leading the charge for at Wonderlamp?. My most challenging part so far was our management buy-out in 2015 that made us a stat-up again. I am most proud of the team that stayed with us and works so hard on making our vision come true. I am a general manager amongst general managers - thats the environment you need in a start-up. Everybody is an entrepreneur. It is my job to make sure everybody knows to use her/his best judgement in everything they do. I am currently busy finding strategic investors to allow us to speed up.. 2. You founded Virtual Reality e.V. Berlin-Brandenburg, an initiative which takes on the massive task of organizing VR ...
Tim Schindler PhD 02, MBA 95, is an employee of the federal government who was furloughed during the partial government shutdown.. ...
Alma Schindler Mahler is famous for marrying and having affairs with some of the most brilliant and accomplished men of the 20th century. She was a composer, sculptor and writer who wanted to be famous for her own intellectual creations, but she lived at a time when it was extremely difficult for women to be prominent in the arts. She took the next best approach by marrying and loving some of the leading musicians, composers, architects, painters and writers of the era.
Directed by Oliver Schindler. This 105-minute wildlife documentary is a must see for all nature lovers but is also suited for scuba divers in search of new dive sites. The underwater filming of this elaborate true 3D production took more than 5 months. Synopsis: The documentary is filmed about 90% underwater and is divided into eight chapters. A wealth of information is given on the individual regions and their resident ...
Faculty members Bryan Chin, Anton Schindler and Jorge Valenzuela have been appointed to three newly endowed professorships within the Samuel Ginn College of Engineering.
In the early morning hours of Jan. 21, the day President Obama is scheduled to be inaugurated, the Presidential Inaugural Prayer Breakfast will be sounding a powerful warning to Washington, D.C., to - in the words of its keynote speaker - turn from its prideful ways or face the judgment of God.. Rabbi Jonathan Cahn, the controversial author of "The Harbinger" - the startling New York Times bestseller that claims the U.S. is receiving the same divine warnings ancient Israel once did … and following the same path to destruction - has been chosen to deliver the keynote address of the Presidential Inaugural Prayer Breakfast, to be held from 7-11 a.m. at the Washington Marriott Wardman Park.. Other distinguished guests - including Rep. Michele Bachmann, R-Minn., Dr. Pat Robertson, Jan Crouch, Pat Boone, WND Editor and CEO Joseph Farah, Rosemary Schindler, Sen. Roy Blunt, R-Mo., and others - are also scheduled to appear at the prayer breakfast.. No book in 2012 made more of a national impact than ...
After tracking down a wild boar in the Eurasian country of Georgia, Bill Schindler raised a primitive spear-thrower called an atlatl and speared his next meal.
Schindlers story, a kind of naval Matthew Shepard murder, bears recalling since his convicted killer is up for regular clemency reviews and the made-for-TV movie left out the hard work of gay activists such as Michael Petrelis. Schindler was a closeted sailor aboard USS Belleau Wood who was being harassed by homophobic shipmates. In late October 1992, he was found murdered in a public restroom near his base in Sasebo, Japan. His head and face were so bashed in his mother couldnt recognize him. Sailors Charles Vins and Terry Helvey were arrested. In early November the Navy cut a sweetheart deal with Vins. In exchange for testimony against Helvey, Vins was quietly sentenced to four months in jail, Petrelis recalls ...
Joi, 20 Mai 2010, ora 19:30, Sala Radio Bucuresti. Pe 20 mai, ultimul concert din prima parte a stagiunii! Dirijor Florin TOTAN, invitat special Monica Balasoiu (vioara) Orchestra Reprezentativa a Armatei va sustine ultimul concert din prima parte a stagiunii la Sala Radio din Bucuresti, pe data de 20 mai 2010, cu incepere de la ora 19.30. Evenimentul este organizat de Asociatia Culturala Teocta si Kompas Events, cu sprijinul extraordinar al Centrului Cultural European Sector 6 si al Centrului Cultural pentru UNESCO „Nicolae Balcescu" , urmand sa se intoarca in septembrie in ceea de a doua parte a stagiunii unde surprizele vor fi si mai mari.. Dupa rasunatorul succes repurtat in februarie cu concertul sustinut alaturi de Orchestra Reprezentativa a Armatei, apreciatul dirijor Florin TOTAN revine. In concertul din luna mai, publicul va avea ocazia sa asculte muzica din filme celebre ca „Piratii din Caraibe", „Mihai Viteazul", „Lista lui Schindler", ‚Hook" si altele ...
Kuster, G. M. and Nietlispach, F. and Kiowski, W. and Schindler, R. and Bernheim, A. and Schuetz, P. and Mueller, B. and Morgenthaler, N. G. and Rüter, F. and Riesen, W. and Rickli, H. and Brunner-La Rocca, H. P. ...
(NaturalNews) One of the worlds most lucrative industries, spending on cancer drugs reached an all-time high last year, as it was valued at more than $100 billion. Spending on cancer drugs increased 6.5 percent annually over the past five years and is expected to continue growing at a rate of 8 percent each year through…
According to Thebigriddle.com: Nagalase is a protein thats also created by all cancer cells. This protein is also found in very high concentrations in autistic children. And theyre PUTTING it in our vaccines!!. This prevents the body from utilizing the Vitamin D necessary to fight cancer and prevent autism. Nagalese disables the immune system. Its also known to cause Type 2 Diabetes. So basically…they werent killing these doctors because they had found the cure to cancer or were successfully treating autism…theyre killing them because these Drs had been researching and had the evidence that the vaccines theyre injecting our precious children with are CAUSING our current cancer and autism crisis!!. And that its obviously being done knowingly and on purpose! The Drs they killed in FL had been collaborating and were getting ready to go public with the information.. Depopulation 101..add poison to vaccines…make it law that all children must be injected to attend school. Slow kill ...
SV40 just loves the kidneys, makes its home either there or in the brain of infected monkeys. Your cervical cancer was likely it trying to get to your brain. A friend of mine, kid who was standing beside me in line to get the Salk vaccine, hit the lottery, then died of kidney disease, which was likely SV40 related. Louise, you need to look at other ages, remembering in 1955 that it wasnt only the wee kids that got the vaccine. My father, for example, was 17 in 1955. Hes still going, but the virus has been hard on him. Also look at kidney disease rates, not just cancer. You folks think your blood is rare, his is AB-. Something I noted, is that both he and I were at one time Rh+. Something has taken away the Rh factor. It takes time, but something is able to do it, as Dawn Smith has postulated. Nagalase, an enzyme that would be naturally present in vaccines, and made by a lot of different microbes, can destroy the surface antigens of type A and B blood! Its also naturally produced by humans, in ...
The purpose of the Global Public Inclusive Infrastructure (GPII) is to ensure that everyone who faces accessibility barriers due to disability, literacy, digital literacy, or aging, regardless of economic resources, can access and use the Internet and all its information, communities, and services for education, employment, daily living, civic participation, health, and safety (Raising the Floor, 2011). The mechanism behind this effort is the creation of a system that allows the individual to define a set of access preferences which are stored "in the cloud," then to call up those preferences from any information technology which is GPII enabled, and have the system automatically configure the device to match the individuals needs. When the individual is done using the device, it will automatically revert to its base state.. Allowing the individual to call personal preferences from the cloud independently saves the individual from being forced to disclose his/her, and assures that the ...
... - Sho Kanzaki, Kohei Kawamoto, Seung-Ha Oh, Timo Stöver, Mitsuya Suzuki, Shinichi Ishimoto, Masao Yagi, Josef M Miller, Margaret I Lomax, Yehoash Raphael
Lady Bird Johnson Wildflower Center focused on protecting and preserving North Americas native plants through native plant lists and image galleries, conservation, education, natural landscapes, seed collection - Millennium Seed Bank (MSB) Project, preserving and restoring native communities, spreading awareness on invasive species and gardening to attract wildlife. We deliver useful information, latest low impact development trends and techniques, useful gardening tips, innovative approaches and tools to use native plants and preserve natural landscapes.
A simple preparation method and PCR protocol are described which allow successful PCR amplification of partial ribosomal RNA gene sequences from as little as one dinoflagellate cyst or vegetative cell. Amplification from single or small numbers of cysts can be applied to a range of morphologically identifiable cyst species and produces identical rDNA sequence data to those obtained from DNA extractions from cultured vegetative cells. Applications of the approach have the potential to aid phylogenetic studies of dinoflagellates and other microalgae by: (1) improving taxonomic sampling of unculturable and heterotrophic species; (2) providing data to link cysts of unknown affinity with their potential planktonic cell counterparts; and (3) confirming the identification of cysts that cannot be germinated or are non-viable. Examples are presented where this method was used to confirm the identity and distribution of nonviable microreticulate cysts in coastal marine sediment samples, such as those of ...
Perforation of the stomach is said to occur very infrequently following the use of the flexible gastroscope. According to Schindler and Renshaw,1 this accident is known to have occurred five times in a total series of four thousand examinations carried out independently by Henning, Gutzeit, Moutier, Benedict, Schloss, and Schindler. In every instance an instrument with a "sponge tip" was used, and in none was the outcome fatal.(Perforation of the stomach is said to occur very infrequently following the use of the flexible gastroscope. According to Schindler and Renshaw,1 this accident is known to have occurred five times in a total series of four thousand examinations carried out independently by Henning, Gutzeit, Moutier, Benedict, Schloss, and Schindler. In every instance an instrument with a "sponge tip" was used, and in none was the outcome fatal.‡ In two instances the stomach itself was reported to be "apparently normal," and recovery occurred without surgical intervention. In Schindlers ...
Cultural eutrophication stimulated by anthropogenic-derived nutrients represents one of the most common forms of compromised surface water quality in many developed and developing countries (Schindler 2012). In fresh water, both nitrogen (N) and phosphorus (P) can potentially contribute to eutrophication (Carpenter et al. 1998). In lakes it is more common that excessive P inputs are the primary cause of eutrophication (Schindler 1977) although both global (Elser et al. 2007) and national surveys (Abell et al. 2011a) have increasingly highlighted excessive N inputs as an equal or more important cause. Debate on the relative roles of N and P limitation of lake phytoplankton is highly contentious, with a P-limitation paradigm (Schindler et al. 2008) challenged by those who contend that both P and N control are key elements of eutrophication management in freshwater systems (e.g. Conley et al. 2009; Scott and McCarthy 2010). Eutrophication of temperate estuaries and coastal waters is also common, ...
Due to the limitations on flexibility, the patient had to be positioned in order that the gastroscope could simply slide down the oesophagus towards the stomach. It would then be rotated to visualize all areas of the stomach. Not the easiest of procedures. For gastroscopy to advance, something had to be done to the gastroscope itself.. Rudolf Schindler (1888-1968) was a German doctor who specialised in gastroenterology. Considered the "father of gastroscopy", Schindler made incredible efforts to promote the use of gastroscopy as a diagnostic technique for gastrointestinal conditions [1].. Schindler was the brains behind the first ever semi-flexible gastroscope, created in 1931 [2]. He constructed the gastroscope in such a manner that the distal end could be rotated, while the proximal end remained stationary (see image below). This allowed easier access to all areas of the stomach. But how did he test his design? Often, his instruments were tested on his own children, especially his daughter ...
Neuroaxonal Dystrophy. By Jeaneane P. Kozlowski Presented June 24, 2003 Temple University- Ambler. What is Neuroaxonal Dystrophy?. Neuroaxonal Dystrophy (NAD) is a rare inherited disorder. Slideshow 6866545 by herman-munoz
The test measures the activity of alfa-N-acetylgalactosaminidase (nagalase) in blood. Nagalase is an extracellular matrix-degrading enzyme that is (increased) secreted by cancerous cells in the process of tumour invasion. It also is an intrisic component of envelope protein of various virions, such as HIV and the influenza virus. It is secreted from virus-infected cells..1,3,4. Nagalase deglycosylates the vitamin D3-binding protein DBP (in humans better known as Gc-protein). Gc-protein is the precursor for the major macrophage-activating factor (MAF). Gc-protein carries one trisaccharide consisting of N-acetylgalactosamine with dibranched galactose and sialic acid termini. By the deglycosylation the (complete) trisaccharide is removed from the Gc-protein. The glycosylated Gc-protein cannot be converted to MAF anymore.. Normally MAF is produced from Gc-protein by sequential removal of the galactose and sialic acid termini from this protein by respectively beta-galactosidase of inflammation- ...
Angiokeratoma removal treatments with radiosurgery adn CO2 laser therapy angiokeratoma or small scrotal skin tags harmless angiokeratoma genital bumps causes and symptoms angiokeratoma treatments
Tellurium sulfates from reaction in oleum and sulfur trioxide: Syntheses and crystal structures of TeO(SO4), Te4O3(SO4)5, and Te(S2O7)2 ...
Pixdaus.com is an environmental photo-bookmarking and sharing service. All the pictures are uploaded by users and the copyrights belong to the rightholders. You can request a removal using the Copyright flag link below each image if you find an image that shouldnt belong here ...
Angiokeratoma definition, a skin disease characterized by clusters of dilated blood vessels and by thickened skin, forming warty growths, especially on the scrotum, fingers, and toes. See more.
Dr. Karen Blakemore, M.D., director of prenatal genetics at the Prenatal Diagnostic Center in the Johns Hopkins Department of Gynecology and Obstetrics, Julie Cohen, certified genetic counselor in the Center for Genetic Muscle Disorders at the Kennedy Krieger Institute, and Alice Schindler, MS, genetic counselor at the National Institutes of Neurological Disorders and Stroke (NINDS), provide a comprehensive overview of family planning strategies and considerations for families living with myotonic dystrophy - at the 2016 MDF Annual Conference.. ...
By Kiran Yanamandra, Tirth K. Patel, Hong Jiang, Suzanne Schindler, Jason D. Ulrich, Adam L. Boxer, Bruce L. Miller, Diana R. Kerwin, Gilbert Gallardo, Floy Stewart, Mary Beth Finn, Nigel J. Cairns, Philip B. Verghese, Ilana Fogelman, Tim West, Joel Braunstein, Grace Robinson, Jennifer Keyser, Joseph Roh, Stephanie S. Knapik, Yan Hu, David M. Holtzman. Science Translational Medicine ...
By Kiran Yanamandra, Tirth K. Patel, Hong Jiang, Suzanne Schindler, Jason D. Ulrich, Adam L. Boxer, Bruce L. Miller, Diana R. Kerwin, Gilbert Gallardo, Floy Stewart, Mary Beth Finn, Nigel J. Cairns, Philip B. Verghese, Ilana Fogelman, Tim West, Joel Braunstein, Grace Robinson, Jennifer Keyser, Joseph Roh, Stephanie S. Knapik, Yan Hu, David M. Holtzman. Science Translational Medicine ...
ASSOCIATION BETWEEN NUTRITIONAL STATUS AND QUALITY OF LIFE IN (PRE)FRAIL COMMUNITY-DWELLING OLDER PERSONS. E. Luger, S. Haider, A. Kapan, K. Schindler, C. Lackinger, T.E. Dorner. J Frailty Aging 2016;5(3):141-148. Show summaryHide summary. Background: For developed countries, healthy aging is one of the challenges and the number of healthy life years and especially the quality of life (QoL) are important. Objective: This study aimed to assess the association between nutritional status and different domains of QoL in (pre)frail community-dwelling elders. Design: Baseline data from persons, who participated in a 12-week nutritional and physical training intervention program, conducted from September 2013 - July 2015. Setting: (Pre)frail community-dwelling elders living in Vienna, Austria. Participants: A total of 83 older persons living at home, 12 men and 71 women (86%) aged 65 to 98 years. Measurements: Structured interviews were conducted at participants homes. Mini Nutritional Assessment® ...
von Bernuth, H, Ravindran, E, Du, H, Fröhler, S, Strehl, K, Krämer, N, Issa-Jahns, L, Amulic, B, Ninnemann, O, Xiao, M-S, Eirich, K, Kölsch, U, Hauptmann, K, John, R, Schindler, D, Wahn, V, Chen, W & Kaindl, AM, 2014, Combined immunodeficiency develops with age in Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) . Orphanet Journal of Rare Diseases, vol 9., pp. 116 ...
Refill not Landfill is a campaign to promote healthier living through sustainable water habits during the month of November. Free water bottles will be available from 9 a.m. to 2 p.m. in Schindler Education Center, noon to 2 p.m. at the Wellness/Recreation Center and 9 a.m. to noon at Maucker Union, Rod Library and Curris Business Building Tuesday, Oct. 31. Did you know there are more than 65 refill stations located around the UNI campus to make it easy to get your 64 ounces of recommended water every day? Find us on Facebook at Recycling and Reuse Technology Transfer Center to get daily tips and facts about healthy living through sustainable waters habits.. Location: campus. ...
This book is an investigation of how semivowels were realised in Indo-European and in early Greek. More specifically, it examines the extent to which Indo-European *i and *y were independent phonemes, in what respects their alternation was predictable, and how this situation changed as Indo-European developed into Greek. Evidence from Greek, Germanic and Vedic are crucial for understanding the Indo-European situation; this book undertakes a re-examination of the evidence provided by Gothic and Vedic, and offers the first comprehensive survey of the Greek evidence. The impact of this evidence on the theories of Sievers, Edgerton, Lindeman, Schindler and Seebold is assessed. This inquiry has significant morphological as well as phonological components; a proper understanding of the early behaviour of semivowels depends on disentangling considerable morphological innovation in the comparative adjectives in *-yos-/-iyos-, the nominals in *-ye/o-, *-iye/o-, *-y-e/o-, *-i-(y)e/o-, and *-tye/o-, the feminine
Schneider, E; Muller, B; and Schindler, R, "Effects of temperature changes on thymidine kinase in heat-and cold-sensitive cell-cycle mutanta and wild-type murine p-815 cells." (1983). Subject Strain Bibliography 1983. 1696 ...
Volume 638, Issue 12-13, October 2012, Pages: 2069-2077, Sandra Kisslinger, Harald Kelm, Sipeng Zheng, Alexander Beitat, Christian Würtele, Ramona Wortmann, Sylvestre Bonnet, Sonja Herres-Pawlis, Ph.D. Hans-Jörg Krüger and Prof. Dr. Siegfried Schindler. Version of Record online : 24 AUG 2012, DOI: 10.1002/zaac.201200237. ...
by Khadija Said, Jerry Hella, Stefanie Knopp, Tatu Nassoro, Neema Shija, Fatma Aziz, Francis Mhimbira, Christian Schindler, Upendo Mwingira, Anna M. Mandalakas, Karim Manji, Marcel Tanner, Jürg Utzinger, Lukas Fenner Background Despite the high prevalence of helminth infections among preschool-aged children, control programs in sub-Saharan countries primarily focus on school-aged populations. We assessed the prevalence of helminth infections and determined risk factors for infection among preschool-aged children in the urban setting of Dar es Salaam, Tanzania.
Opel has launched the European component of GMs biggest-ever test program for fuel cell vehicles. Nine companies will be the first to operate the GM/Opel HydroGen4 zero emission vehicles in the Berlin area: ADAC, Allianz, Coca-Cola, Hilton, Linde, Schindler, Axel Springer, Total and Veolia. Members of the HydroGen4 fleet in...
On Thu, 3 Oct 2002, Kanovei wrote: , Generally, there is no way to define ZFC-truth other than to , extend the language of ZFC. , Three typical methods are known. [...] , Third, consider a second-order impredicative theory of classes. One doesnt need an *im*predicative theory of classes here, one can do with predicative classes. (A class is predicative iff it can be defined by a fmla of set theory + parameters for sets.) --Ralf -- --------------------------------------------------------------------- Ralf Schindler Phone: +43-1-4277-50511 Institut fuer Formale Logik Fax: +43-1-4277-50599 Universitaet Wien E-mail: rds at logic.univie.ac.at 1090 Wien, Austria URL: http://www.logic.univie.ac.at/~rds/ ...
If these walls could talk.. Celebrities have fueled Hot Property headlines, but many homes have achieved their own fame.. Some star homes count a parade of famous names among past and present owners, while others are Los Angeles historic landmarks. Some have gained fame as the result of their architects; others by a convergence of factors.. For a house to become a star in its own right it needs a certain timelessness or agelessness, said Jeff Hyland of Hilton & Hyland, an affiliate of Christies International Real Estate, and author of "The Legendary Estates of Beverly Hills.". "When you have a house that is a classic Wallace Neff design or an authentic Paul Williams, that is the real thing," Hyland said. "Those designs transcend anything.". Los Angeles has homes by many enduring architects, such as modernists John Lautner, Richard Neutra and Rudolph Schindler, Hyland said. "Plus, you find every architectural style in the world here.". When Bret Parsons described the interiors of Nicolas Cages ...
Angiokeratomas are papular vascular lesions characterized by marked ectasia of the superficial dermal blood vessels. Dermatological examination of angiokeratomas of Fordyce is characterized by papular keratotic lesions of erythematous-violet color. They are more common in the scrotum, and vulval involvement is rarely reported. This article reports the cases of angiokeratoma of Fordyce in a 25-year-old man and a 42-year-old woman. Diagnosis were made by history and physical examination. Dermoscopy has shown well-demarcated round dark lacunae in both patients. As the lesions were asymptomatic, the patients requested no further treatment ...
NaturalNews) One of the worlds most lucrative industries, spending on cancer drugs reached an all-time high last year, as it was valued at more than $100 billion. Spending on cancer drugs increased 6.5 percent annually over the past five years and is expected to continue growing at a rate of 8 percent each year through 2018, according to figures provided by the IMS Institute for Healthcare Informatics.. That spending is highly concentrated, as the US and five of Europes largest countries account for nearly two-thirds of the entire market.. This means that billions and billions of dollars are secured by Americans being diagnosed with cancer.. Thats one profitable industry; however, it could all be completely dismantled by one thing: a cure.. As Mike Adams recently reported, "A universal cancer cure would destroy the profitability of the highly lucrative cancer industry and collapse the American Cancer Society, hospitals, oncology clinics and pharmaceutical companies that depend on chemotherapy ...
A description of tropes appearing in Vision of Escaflowne. Hitomi Kanzaki is an Ordinary High-School Student who reads tarot cards and runs on her schools …
To start IS season 2 lacks 3 things, one is plot, two is character development, and three is the action that was promised. I loved season 1 and when I watched and finished season 2 I just cried. I sat on my lazy chair and just cried over how bad this season was. To start off you have this brand new plot that seems promising enough to continue the show. Wow this season could be the 24 episode action packed, busty chicks in mech suits weve all been waiting for, NOPE. Instead it slaps us in the face and says haha you only get 12 episodes 3 episodes focusing solely on plot, the rest you ask? All fucking FILLER!!! I mean seriously there were about 4 episodes that honestly you dont need to watch and no one would know, they attain to nothing useful or important whatsoever. Second we have new characters the Kanzaki twins, who did I mention get NO CHARACTER DEVELOPMENT, and Ichikas apparently other sister who is part of this terrorist party full of IS Type 4 bearers. Oh and by the way none of that ...
WIRO SABLENG Pendekar Kapak Maut Naga Geni 212 Karya: Bastian Tito Episode : TUA GILA DARI ANDALAS SATU Setan Ngompol pegang lengan nenek di sebelahnya seraya berkata. Aku melihat ada dinding batu di bawah sana. Mari kita selidiki.... sinenek yang bukan lain adalah Sinto Gendeng guru Pendekar 212 langsung mengomel.Aku kemari mencari Pedang Naga Suci…
Looking for online definition of angiokeratoma corporis diffusum in the Medical Dictionary? angiokeratoma corporis diffusum explanation free. What is angiokeratoma corporis diffusum? Meaning of angiokeratoma corporis diffusum medical term. What does angiokeratoma corporis diffusum mean?
Infantile neuroaxonal dystrophy is a rare pervasive developmental disorder that primarily affects the nervous system. Individuals with infantile neuroaxonal dystrophy typically do not have any symptoms at birth, but between the ages of about 6 and 18 months they begin to experience delays in acquiring new motor and intellectual skills, such as crawling or beginning to speak. Eventually they lose previously acquired skills. This condition is inherited in an autosomal recessive pattern, which means two copies of the gene (PLA2G6) in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder each carry one copy of the altered gene but do not show signs and symptoms of the disorder. Mutations in the PLA2G6 gene have been identified in most individuals with infantile neuroaxonal dystrophy. The PLA2G6 gene provides instructions for making an enzyme called an A2 phospholipase. This enzyme family is involved in metabolizing phospholipids. Phospholipid metabolism ...
NINDS : 51 Infantile neuroaxonal dystrophy (INAD) is a rare inherited neurological disorder. It affects axons, the part of a nerve cell that carries messages from the brain to other parts of the body, and causes progressive loss of vision, muscular control, and mental skills. While the basic genetic and metabolic causes are unknown, INAD is the result of an abnormal build-up of toxic substances in nerves that communicate with muscles, skin, and the conjunctive tissue around the eyes. Symptoms usually begin within the first 2 years of life, with the loss of head control and the ability to sit, crawl, or walk, accompanied by deterioration in vision and speech. Some children may have seizures. Distinctive facial deformities may be present at birth, including a prominent forehead, crossed eyes, an unusually small nose or jaw, and large, low-set ears. INAD is an autosomal recessive disorder, which means that both parents must be carriers of the defective gene that causes INAD to pass it on to their ...
This urinary oligosaccharide and glycan screening is using MALDI-TOF/TOF technology, which provides a better sensitivity and specificity than the traditional TLC method. Different from the traditional TLC method, this method successfully detects subtle excretions of abnormal oligosaccharides in mucolipidosis II and III ( I cell disease) as well as other oligosaccharidoses. Conditions screened for are the following: Fucosidosis, Alpha-mannosidosis, Beta-mannosidosis, Sialidosis, Aspartylglucosaminuria, Schindler disease, Kanzaki disease, Mucolipidosis II and III ( I cell disease), Galactosialidosis, CDGIIb, Pompe disease, and Tay Sachs / Sandhoff (GM2).. ...
Fabry disease (FD) is an X-linked lysosomal storage disease and is the result of mutation in the α-Galactosidase A gene; such mutations cause a deficiency in α-Galactosidase A enzyme and an accumulation of glycosphingolipid in tissue. Affected males with classic FD have little or no enzyme activity and have an early onset of symptoms and signs, including acroparesthesias, hypohidrosis, angiokeratomas, gastrointestinal dysfunction and/or a characteristic corneal dystrophy during childhood/adolescence. Males with late-onset FD who have residual enzyme activity develop progressive multi-systemic involvement that leads to renal failure and hypertrophic cardiomyopathy, as well as cerebrovascular disease; these events mostly occur during the fourth to seventh decades of life. Read More ...
Read the medical definition of an inherited disease called Fabry disease. Fabry disease is also known as Anderson-Fabry disease and angiokeratoma corporis diffusum universale.
At least 50 mutations in the PLA2G6 gene have been identified in people with infantile neuroaxonal dystrophy, a progressive neurological disorder that causes intellectual disability and movement problems. Mutations in the PLA2G6 gene eliminate or severely impair the function of the PLA2 group VI enzyme. Impairment of PLA2 group VI enzyme function may disrupt cell membrane maintenance and contribute to the development of swellings called spheroid bodies in the axons, which are fibers that extend from nerve cells (neurons) and transmit impulses to muscles and other neurons. Although it is unknown how changes in this enzymes function lead to the signs and symptoms of infantile neuroaxonal dystrophy, phospholipid metabolism problems have been seen in both this disorder and a similar disorder called pantothenate kinase-associated neurodegeneration. These disorders, as well as the more common Alzheimer disease and Parkinson disease, also are associated with changes in brain iron metabolism. ...
Penis irritation and itchiness could look like a rash, red bumps, or blisters on the penis. This area may become affected without other areas of skin showing the same problem. It is not hard to accidentally scrape your scrotum with a razor if one is not careful. Whole blood needs to be put back into the system. Each testicle is covered by a tough, strong membrane called the vaginal tunic. Is it mandatory to stay at the hospital overnight for a microsuction?. Angiokeratoma of Fordyce. Puncture wounds are small openings in the skin produced by pointed objects such as teeth. Unusual Bleeding From Scrotal Skin -A Case Report with Review of Literature. The lesions are only on the scrotum. The incision should be made at the distal end of the scrotum, not near the penis, because if an abscess occurs it can be more serious near the penis, while distal abscesses tend to be benign. I have these papules that are pretty much blackheads (filled with sebum) at the base of my penis, on the scrotum. Bleeding ...
Manganese (Mn) is an essential trace mineral for normal growth and development. Persistent exposures to high atmospheric levels of Mn have deleterious effects on CNS and peripheral nerves including those associated with the auditory system. Nicotinamide adenine dinucleotide (NAD) is a coenzyme which functions in the electron transfer system within the mitochondria. One of the most notable protecti
In general, the ultrastructural features of BSE-affected pig brain were similar to those of BSE-affected cattle [46,66,67] and humans with TSEs [60,61]. Spongiform change in the form of membrane-bound vacuoles (Fig. 1) separated by membranes curled into secondary chambers dominated the pathology. A dense astrocytic reaction was accompanied by abundant elongated microglial cells. Of particular note was the finding of numerous astrocytic processes in close conjunction with microglial cells. Neuronal degeneration presented as either neuroaxonal dystrophy, as evidenced by dystro - phic neurites, or autophagic vacuoles. Dystrophic neurites accumulated altered subcellular organelles: mitochondria (Fig. 1B), electron-dense bodies, neurofilaments and "branching-cisterns" (Fig. 2). Autopha - gic vacuoles appeared as a part or parts of the neuronal cytoplasm sequestrated by intracytoplasmic membranes (Fig. 3). Sequestrated cytoplasm was of higher electron density than the remaining cytosol. Discontinuity ...
Looking for online definition of seborrhea corporis in the Medical Dictionary? seborrhea corporis explanation free. What is seborrhea corporis? Meaning of seborrhea corporis medical term. What does seborrhea corporis mean?

Human alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds - Nucleotide - NCBIHuman alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds - Nucleotide - NCBI

Human alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds Human alpha-N-acetylgalactosaminidase (NAGA) gene, complete cds ... NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ...
more infohttps://www.ncbi.nlm.nih.gov/nucleotide/M59199

Infantile Neuroaxonal Dystrophy 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical TrialsInfantile Neuroaxonal Dystrophy 1 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Alpha-N-Acetylgalactosaminidase. 35.83. DISEASES inferred 14 Novoseek inferred 52 GeneCards inferred via :. Disorders (show ...
more infohttp://www.malacards.org/card/infantile_neuroaxonal_dystrophy_1

Department of Biochemistry and Molecular Biology | UMass AmherstDepartment of Biochemistry and Molecular Biology | UMass Amherst

The 1.9 A structure of human alpha-N-acetylgalactosaminidase: The structural basis of Schindler and Kanzaki diseases. Journal ... Garman, S.C., Hannick, L., Zhu, A., and Garboczi, D.N. (2002) "The 1.9 Å structure of α-N-acetylgalactosaminidase: molecular ... Mutant alpha-galactosidase A enzymes identified in Fabry disease patients with residual enzyme activity: biochemical ... We have determined the x-ray crystallographic structures of two lysosomal glycosidases, α-N-acetylgalactosaminidase (α-NAGAL) ...
more infohttp://www.umass.edu/biochem/faculty/scott-garman

Schindler disease, type 1Schindler disease, type 1

Alpha-N-acetylgalactosaminidase (NAGA) deficiency is a very rare lysosomal storage disorder. It is clinically heterogeneous ... Condition Summary: Aspartylglucosaminuria; Fucosidosis; Galactosialidosis; Alpha Mannosidosis; Beta Mannosidosis; Mucolipidosis ... https://ghr.nlm.nih.gov/condition/alpha-1-antitrypsin-deficiency. https://ghr.nlm.nih.gov/condition/glycogen-storage-disease- ...
more infohttp://www.diseaseinfosearch.org/Schindler+disease%2C+type+1/6437

NAGA - Alpha-N-acetylgalactosaminidase - Gallus gallus (Chicken) - NAGA gene & proteinNAGA - Alpha-N-acetylgalactosaminidase - Gallus gallus (Chicken) - NAGA gene & protein

Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of ... Alpha-N-acetylgalactosaminidaseAdd BLAST. 405. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... "The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.". Garman S.C., ... "The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.". Garman S.C., ...
more infohttps://www.uniprot.org/uniprot/Q90744

Alpha-N-acetylgalactosaminidase - WikipediaAlpha-N-acetylgalactosaminidase - Wikipedia

Mutations in this gene and the deficiency in alpha-N-acetylgalactosaminidase activity have been identified as the cause of ... the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy". J. Clin. ... α-N-acetylgalactosaminidase (EC 3.2.1.49) is a glycoside hydrolase from bacteria and animals, also known as nagalase. The human ...
more infohttps://en.wikipedia.org/wiki/Alpha-N-acetylgalactosaminidase

Endo-alpha-N-acetylgalactosaminidase - WikipediaEndo-alpha-N-acetylgalactosaminidase - Wikipedia

Endo-alpha-N-acetylgalactosaminidase may refer to: Mucinaminylserine mucinaminidase, an enzyme Glycopeptide alpha-N- ...
more infohttps://en.wikipedia.org/wiki/Endo-alpha-N-acetylgalactosaminidase

Production of Universal Group O Red Blood Cells by Alpha- N-Acetylgalactosaminidase Enzyme Expressed in Pichia pastoris |...Production of Universal Group O Red Blood Cells by Alpha- N-Acetylgalactosaminidase Enzyme Expressed in Pichia pastoris |...

In this research, an α- N-acetylgalactosaminidase (NAGA) enzyme was expressed in ... ... Tuppy H, Staudenbauer WL (1966) The action on soluble blood group A substances of an alpha-N-acetylgalactosaminidase from Helix ... Production of Universal Group O Red Blood Cells by Alpha-N-Acetylgalactosaminidase Enzyme Expressed in Pichia pastoris. ... Hsieh HY, Chapman LF, Calcutt MJ, Mitra M, Smith DS (2005) Recombinant Clostridium perfringens alpha-N-acetylgalactosaminidase ...
more infohttps://link.springer.com/article/10.1007%2Fs12288-018-0999-9

Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from...Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from...

Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ... Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ... Initial observations of elevated alpha-n-acetylgalactosaminidase activity associated with autism and observed reductions from ...
more infohttp://www.researchautism.net/publications/5832/initial-observations-of-elevated-alpha-n-acetylgalactosaminidase-activity-associated-with-autism-and-observed-reductions-from-gc-protein:-macrophage-activating-factor-injections-?a_col=lightblueblack

Alpha-N-acetylgalactosaminidaseAlpha-N-acetylgalactosaminidase

NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from ... Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of ... Alpha-N-acetylgalactosaminidase deficiency type 1. 1. Alpha-N-acetylgalactosaminidase deficiency type 3. 1. ...
more infohttps://pharos.nih.gov/idg/targets/NAGA

KEGG ENZYME: 3.2.1.49KEGG ENZYME: 3.2.1.49

alpha-acetylgalactosaminidase;. N-acetyl-alpha-D-galactosaminidase;. N-acetyl-alpha-galactosaminidase;. alpha-NAGAL;. alpha- ... The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases. ... Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast. ... Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus ...
more infohttps://www.genome.jp/dbget-bin/www_bget?enzyme+3.2.1.49

Deep characterization of the anti-drug antibodies developed in Fabry disease patients, a prospective analysis from the French...Deep characterization of the anti-drug antibodies developed in Fabry disease patients, a prospective analysis from the French...

... is an X-linked disorder caused by alpha-galactosidase A deficiency with two major clinical phenotypes: classic and non-classic ... 4c). Whereas the alpha-galactosidase B also known as alpha-N-acetylgalactosaminidase (NAGA) enzyme shares 46 to 62% homology in ... Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha- ... Alpha-N-acetylgalactosaminidase (NAGA) neutralizing assay. Human recombinant NAGA (2.5 and 5 ng/μl, R&D Systems®) was incubated ...
more infohttps://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0877-4

N - Genes - Genetics Home Reference - NIHN - Genes - Genetics Home Reference - NIH

NAGA: alpha-N-acetylgalactosaminidase. *NAGLU: N-acetyl-alpha-glucosaminidase. *NAGS: N-acetylglutamate synthase ...
more infohttps://ghr.nlm.nih.gov/gene?initial=n

Lysosomal Storage Disorders - NORD (National Organization for Rare Disorders)Lysosomal Storage Disorders - NORD (National Organization for Rare Disorders)

Alpha-N-acetylgalactosaminidase deficiency: p. 138.. GM2-Gangliosidosis: (Tay-Sachs) pp. 49-52; (Sandhoff) pp.235-37. ... Fabry results from a deficiency of the enzyme alpha-galactosidase A, and Fabrazyme is a version of the human form of this ... MPS I is caused by a deficiency of the enzyme alpha L-iduronidase, leading to the accumulation of a carbohydrate called ...
more infohttps://rarediseases.org/rare-diseases/lysosomal-storage-disorders/

SCOPe 2.07: Structural Classification of Proteins - extendedSCOPe 2.07: Structural Classification of Proteins - extended

Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Description: Pharmacological chaperones for human alpha-N-acetylgalactosaminidase. Class: hydrolase/hydrolase inhibitor. ... Keywords: PHARMACOLOGICAL CHAPERONE, BETA/ALPHA)8 BARREL, GLYCOSIDASE, CARBOHYDRATE-BINDING PROTEIN, GLYCOPROTEIN, LYSOSOME, ...
more infohttps://scop.berkeley.edu/pdb/code=4do5

SCOPe 2.03: Structural Classification of Proteins - extendedSCOPe 2.03: Structural Classification of Proteins - extended

Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Compound: alpha-N-acetylgalactosaminidase. Species: Homo sapiens [TaxId:9606]. Gene: nagA. Database cross-references and ... Description: Pharmacological chaperones for human alpha-N-acetylgalactosaminidase. Class: hydrolase/hydrolase inhibitor. ... Keywords: PHARMACOLOGICAL CHAPERONE, (BETA/ALPHA)8 BARREL, GLYCOSIDASE, CARBOHYDRATE-BINDING PROTEIN, GLYCOPROTEIN, LYSOSOME, ...
more infohttp://scop.berkeley.edu/pdb/code=4do4&ver=2.03

Naga - ddPCR Probe - Digital PCR | PrimePCR | Bio-RadNaga - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad

Alpha-N-acetylgalactosaminidase Aliases:. Not Available. RefSeq:. Not Available. Ensembl:. ENSRNOG00000008064 Entrez:. 315165 ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/drnocpe5156341-primepcr-ddpcr-expression-probe-assay-naga-rat

UniProt: A0A0C2RK56 9BACLUniProt: A0A0C2RK56 9BACL

DR GO; GO:0033926; F:glycopeptide alpha-N-acetylgalactosaminidase activity; IEA:InterPro. DR Gene3D; 2.60.120.260; -; 2. DR ...
more infohttp://www.genome.jp/dbget-bin/www_bget?uniprot:A0A0C2RK56_9BACL

2011 ICD-9-CM Diagnosis Code 277.89 : Other specified disorders of metabolism2011 ICD-9-CM Diagnosis Code 277.89 : Other specified disorders of metabolism

Alpha-N-acetylgalactosaminidase deficiency. *Anemia due to disorders of nucleotide metabolism. *Autosomal variant form of ...
more infohttp://www.icd9data.com/2011/Volume1/240-279/270-279/277/277.89.htm

Schindler disease type 1             | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramSchindler disease type 1 | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program

and fats). More specifically, alpha-N-acetylgalactosaminidase helps remove a molecule called alpha-N-acetylgalactosamine from ... Alpha-N-acetylgalactosaminidase deficiency, type 1; NAGA deficiency, type 1; Neuroaxonal dystrophy, Schindler type; Alpha-N- ... alpha-N-acetylgalactosaminidase.This enzyme works in the lysosomes. (compartments within cells. that digest and recycle ... Mutations in the NAGA gene interfere with the ability of the alpha-N-acetylgalactosaminidase enzyme to perform its role in ...
more infohttps://rarediseases.info.nih.gov/diseases/116/schindler-disease-type-1

Kanzaki disease             | Genetic and Rare Diseases Information Center (GARD) - an NCATS ProgramKanzaki disease | Genetic and Rare Diseases Information Center (GARD) - an NCATS Program

Alpha-N-acetylgalactosaminidase deficiency type 2; Alpha-N-acetylgalactosaminidase deficiency adult onset; NAGA deficiency type ... Alpha-N-acetylgalactosaminidase deficiency type 2; Alpha-N-acetylgalactosaminidase deficiency adult onset; NAGA deficiency type ... Alpha-N-acetylgalactosaminidase (NAGA) deficiency type 2 is a very rare mild adult type of NAGA deficiency (see this term) with ...
more infohttps://rarediseases.info.nih.gov/diseases/9161/kanzaki-disease

Sialoglycoproteins
     Summary Report | CureHunterSialoglycoproteins Summary Report | CureHunter

08/01/1991 - "These studies document the occurrence of two forms of alpha-N-acetylgalactosaminidase deficiency and ...
more infohttp://www.curehunter.com/public/keywordSummaryD012795-Sialoglycoproteins.do

Schindler disease - Genetics Home Reference - NIHSchindler disease - Genetics Home Reference - NIH

Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease ... Specifically, alpha-N-acetylgalactosaminidase helps remove a molecule called alpha-N-acetylgalactosamine from sugars in these ... The NAGA gene provides instructions for making the enzyme alpha-N-acetylgalactosaminidase. This enzyme works in the lysosomes, ... Mutations in the NAGA gene interfere with the ability of the alpha-N-acetylgalactosaminidase enzyme to perform its role in ...
more infohttps://ghr.nlm.nih.gov/condition/schindler-disease

Recombinant Human NAGA 293 Cell Lysate NAGA-3983HCL - Creative BioMartRecombinant Human NAGA 293 Cell Lysate NAGA-3983HCL - Creative BioMart

... alpha-; alpha-N-acetylgalactosaminidase; D22S674; alpha-galactosidase B; Acetylgalactosaminidase, alpha-N- (alpha-galactosidase ... alpha-N-acetylgalactosaminidase activity; alpha-galactosidase activity; cation binding; hydrolase activity, hydrolyzing O- ... Antigen standard for N-acetylgalactosaminidase, alpha- (NAGA) is a lysate prepared from HEK293T cells transiently transfected ...
more infohttps://www.creativebiomart.net/description_405649_318.htm

NAGA Antibody 15096-1-AP  | ProteintechNAGA Antibody 15096-1-AP | Proteintech

It removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. It is required for the breakdown ...
more infohttps://www.ptglab.com/Products/NAGA-Antibody-15096-1-AP.htm
  • In Fabry disease (FD, OMIM #301500), mutations in the GLA gene (Xq22.1 300,644) lead to a defect in alpha-galactosidase A with a subsequent accumulation of glycosphingolipids, notably globotriaosylceramide (Gb3) and globotriaosylsphingosine ( lyso Gb3). (biomedcentral.com)