alpha-Mannosidase: An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.Mannosidases: Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.Mannosides: Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.alpha-Mannosidosis: An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.Cereals: Seeds from grasses (POACEAE) which are important in the diet.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Acetylgalactosamine: The N-acetyl derivative of galactosamine.Mannose: A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)Penicillium: A mitosporic Trichocomaceae fungal genus that develops fruiting organs resembling a broom. When identified, teleomorphs include EUPENICILLIUM and TALAROMYCES. Several species (but especially PENICILLIUM CHRYSOGENUM) are sources of the antibiotic penicillin.Citrinin: Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.Atriplex: A plant genus in the CHENOPODIACEAE family.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Isocoumarins: Compounds that differ from COUMARINS in having the positions of the ring and ketone oxygens reversed so the keto oxygen is at the 1-position of the molecule.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Alcohol Dehydrogenase: A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presence of NAD. In alcoholic fermentation, it catalyzes the final step of reducing an aldehyde to an alcohol in the presence of NADH and hydrogen.1-Deoxynojirimycin: An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.Alkaloids: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.PolysaccharidesIndolizinesGlucosamineSearch Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.alpha-L-Fucosidase: An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51.Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase: A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.Hexosaminidase A: A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits. Deficiency of hexosaminidase A due to mutations in the gene encoding the hexosaminidase alpha subunit is a case of TAY-SACHS DISEASE. Deficiency of hexosaminidase A and HEXOSAMINIDASE B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.Hexosaminidases: Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.Hexosaminidase B: A mammalian beta-hexosaminidase isoform that is comprized of hexosaminidase beta subunits. Deficiency of hexosaminidase B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.Fucosidosis: An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS; GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

Endometrial lysosomal enzyme activity in normal cycling endometrium. (1/346)

The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-beta-D-glucosaminidase was relatively high, whilst that of alpha-L-fucosidase and alpha-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle.  (+info)

Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. (2/346)

Hcs77 is a putative cell surface sensor for cell integrity signaling in Saccharomyces cerevisiae. Its loss of function results in cell lysis during growth at elevated temperatures (e.g., 39 degrees C) and impaired signaling to the Mpk1 mitogen-activated protein kinase in response to mild heat shock. We isolated the MID2 gene as a dosage suppressor of the cell lysis defect of an hcs77 null mutant. MID2 encodes a putative membrane protein whose function is required for survival of pheromone treatment. Mid2 possesses properties similar to those of Hcs77, including a single transmembrane domain and a long region that is rich in seryl and threonyl residues. We demonstrate that Mid2 is required for cell integrity signaling in response to pheromone. Additionally, we show that Mid2 and Hcs77 serve a redundant but essential function as cell surface sensors for cell integrity signaling during vegetative growth. Both proteins are uniformly distributed through the plasma membrane and are highly O-mannosylated on their extracellular domains. Finally, we identified a yeast homolog of MID2, designated MTL1, which provides a partially redundant function with MID2 for cell integrity signaling during vegetative growth at elevated temperature but not for survival of pheromone treatment. We conclude that Hcs77 is dedicated to signaling cell wall stress during vegetative growth and that Mid2 participates in this signaling, but its primary role is in signaling wall stress during pheromone-induced morphogenesis.  (+info)

Purification and biochemical characterization of two soluble alpha-mannosidases from Candida albicans. (3/346)

Two soluble alpha-mannosidases, E-I and E-II, were purified from C. albicans yeast cells by a three-step procedure consisting of size exclusion and ion exchange chromatographies in Sepharose CL6B and Mono Q columns, respectively, and preparative nondenaturing electrophoresis. E-I and E-II migrated as monomeric polypeptides of 54.3 and 93.3 kDa in SDS-PAGE, respectively. Some biochemical properties of purified enzymes were investigated by using 4-methylumbelliferyl-alpha-D-mannopyranoside and p-nitrophenyl-alpha-D-mannopyranoside as substrates. Hydrolysis of both substrates by either enzyme was optimum at pH 6.0 with 50 mM Mes-Tris buffer and at 42 degrees C. Apparent Kmvalues for hydrolysis of 4-methylumbelliferyl-alpha-D-mannopyranoside and p-nitrophenyl-alpha-D-mannopyranoside by E-I were 0.83 microM and 2. 4 mM, respectively. Corresponding values for E-II were 0.25 microM and 1.86 mM. Swansonine and deoxymannojirimicin strongly inhibited the hydrolysis of 4-methylumbelliferyl-alpha-D-mannopyranoside by both enzymes. On the contrary, hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside by E-I and E-II was slightly stimulated or not affected, respectively, by both inhibitors. E-I and E-II did not depend on metal ions although activity of the latter was slightly stimulated by Mn2+and Ca2+in the range of 0.5-2 mM. At the same concentrations, Mg2+was slightly inhibitory of both enzymes. Substrate specificity experiments revealed that both E-I and E-II preferentially cleaved alpha-1,6 and alpha-1,3 linkages, respectively.  (+info)

Characterization of a soluble class I alpha-mannosidase in human serum. (4/346)

Class I alpha-mannosidases are thought to exist exclusively as integral membrane proteins that play intracellulary an essential role in the N-glycan biosynthesis. Using [3H]Man9GlcNAc2 as a substrate, we were able to identify a soluble alpha-mannosidase in human serum that trims the substrate Man9GlcNAc2 to Man(5-8)GlcNAc2 with Man6GlcNAc2 being the major product. This serum mannosidase is Ca2+-dependent, sensitive to 1-deoxymannojirimycin but insensitive to the class II inhibitor swainsonine and, hence, belongs to class I mannosidases. The enzymatic properties of the serum class I mannosidase are similar to that of the membrane bound class I mannosidases Golgi-mannosidase IA and IB and Man9-mannosidase.  (+info)

Androgen regulation of glycosidase secretion in epithelial cell cultures from human epididymis. (5/346)

The human epididymis and its secretions actively promote sperm fertilizing capacity and provide protection for spermatozoa against harmful influences. Among epididymal secretions, glycosidases have been recently studied and associated with molecular changes on the sperm surface. In the present work, we studied the influence of different concentrations of testosterone, dihydrotestosterone and cyproterone acetate on the secretion of alpha-glucosidase, N-acetyl-glucosaminidase, beta-glucuronidase and alpha-mannosidase by isolated and cultured epithelial cells from human caput, corpus and cauda epididymides. Cell cultures were obtained from aggregates of isolated tubule fragments plated on extracellular matrix-covered multi-well plates. Activities of the glycosidases were measured in conditioned culture media and were higher in the distal regions of the epididymis. Testosterone and dihydrotestosterone significantly increase the enzyme secretion in a concentration-dependent manner. This increase was higher in corpus and/or cauda than in caput epididymis. Cyproterone acetate caused a dose-dependent decrease in glycosidase secretion in cultures from all epididymal regions. It is concluded that the secretion of epididymal glycosidases is regulated by androgen, being stimulated by dihydrotestosterone and testosterone and inhibited by the androgen antagonist cyproterone acetate.  (+info)

Topological and functional characterization of the N-glycans of soybean (Glycine max) agglutinin. (6/346)

Soybean agglutinin (SBA), is a noncovalently bound tetramer comprised of four identical subunits having a single N-glycan chain, Man9GlcNAc2, that is known to be essential for regeneration of the functional tetrameric structure from unfolded subunits. In this study, SBA was found to have strong affinity for concanavalin A, indicating that the N-glycans are extensively solvent-exposed. The susceptibilities of the N-glycans to alpha-mannosidase and endo-beta-N-acetylglucosaminidase revealed that their distal areas have nonreducing ends embedded among the subunits, whereas their proximal regions are solvent-exposed. Endo-beta-N-acetylglucosaminidase-digested SBA was unable to retain its conformation and gradually unfolded. Periodate-oxidized SBA, whose N-glycans closely correspond to the invariant pentasaccharide core, tended to dissociate into the subunits, but permitted to stay as folded monomers. This SBA species was capable of refolding from unfolded subunits but unable to form the functional tetramer. It seems probable that the proximal regions of the N-glycans function in the formation and stabilization of the subunit conformation, whereas the branches outside the invariant cores stabilize the tetrameric structure.  (+info)

Targeted disruption of the lysosomal alpha-mannosidase gene results in mice resembling a mild form of human alpha-mannosidosis. (7/346)

Alpha-mannosidosis is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the lysosomal alpha-mannosidase, which is involved in the degradation of asparagine-linked carbohydrate cores of glycoproteins. An alpha-mannosidosis mouse model was generated by targeted disruption of the gene for lysosomal alpha-mannosidase. Homozygous mutant animals exhibit alpha-mannosidase enzyme deficiency and elevated urinary secretion of mannose-containing oligosaccharides. Thin-layer chromatography revealed an accumulation of oligosaccharides in liver, kidney, spleen, testis and brain. The cellular alterations were characterized by multiple membrane-limited cytoplasmic vacuoles as seen for instance in liver, exocrine pancreas, kidney, thyroid gland, smooth muscle cells, osteocytes and in various neurons of the central and peripheral nervous systems. The morphological lesions and their topographical distribution, as well as the biochemical alterations, closely resemble those reported for human alpha-mannosidosis. This mouse model will be a valuable tool for studying the pathogenesis of inherited alpha-mannosidosis and may help to evaluate therapeutic approaches for lysosomal storage diseases.  (+info)

Purification and properties of major alpha-D-mannosidase in the luminal fluid of porcine epididymis. (8/346)

A lysosomal type alpha-D-mannosidase was successfully purified by DEAE-Sephacel, Red-Amicon and Superdex 200 column chromatographies from porcine cauda epididymal fluid. The purified enzyme consisted of 63 and 51 kDa subunits at equimolar amounts. It cleaved alpha1-2 linked mannosyl residues and less but significantly cleaved alpha1-3 and alpha1-6 linked mannosyl residues in the high-mannose oligosaccharides. The optimal pH to hydrolyze oligosaccharide was in the acidic pH range (pH 3.5 approximately 4.0). Total alpha-D-mannosidase activities in the porcine epididymal fluid increased from proximal to distal caput epididymis, which maintained to cauda epididymis. At least two kinds of alpha-D-mannosidase (lysosomal type enzyme and 135 kDa alpha-D-mannosidase (MAN2B2)) were contained in the porcine epididymal fluid. The activity of the lysosomal type enzyme is much higher than MAN2B2 at the physiological pH. These results suggest that the lysosomal type alpha-D-mannosidase is the predominantly active enzyme in the luminal fluid of porcine epididymis and that it participates in the glycoprotein modification on the sperm surface during epididymal transit.  (+info)

*Alpha-Mannosidase

... alpha-D-mannosidase, p-nitrophenyl-alpha-mannosidase, alpha-D-mannopyranosidase, 1,2-alpha-mannosidase, 1,2-alpha-D-mannosidase ... GeneReviews/NCBI/NIH/UW entry on Alpha-Mannosidosis OMIM entries on Alpha-Mannosidosis alpha-Mannosidase at the US National ... exo-alpha-mannosidase) is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is alpha-D- ... Humans express the following three alpha-mannosidase isozymes: It can be utilized in experiments that determine the effects of ...

*Golgi alpha-mannosidase II

van den Elsen, J.M., Kuntz, D.A., Rose, D.R., "Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and ... Golgi α-mannosidase II is a key enzyme involved in N-linked Glycan processing. It is inhibited by small molecule swainsonine. ...

*Mannosyl-oligosaccharide 1,2-alpha-mannosidase

... (EC 3.2.1.113, mannosidase 1A, mannosidase 1B, 1,2-alpha-mannosidase, exo-alpha- ... mannose-9 processing alpha-mannosidase, glycoprotein processing mannosidase I, mannosidase I, Man9-mannosidase, ManI, 1,2-alpha ... oligosaccharide alpha-D-mannohydrolase) is an enzyme with systematic name 2-alpha-mannosyl-oligosaccharide alpha-D- ... Mannosyl-oligosaccharide 1,2-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular ...

*Mannan endo-1,6-alpha-mannosidase

... (EC 3.2.1.101, exo-1,6-beta-mannanase, endo-alpha-1->6-D-mannanase, endo-1,6-beta-mannanase, ... mannan endo-1,6-beta-mannosidase, 1,6-alpha-D-mannan mannanohydrolase) is an enzyme with systematic name 6-alpha-D-mannan ... Mannan endo-1,6-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... This enzyme catalyses the following chemical reaction Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1 ...

*Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

6-alpha-mannosidase (EC 3.2.1.114, mannosidase II, exo-1,3-1,6-alpha-mannosidase, alpha-D-mannosidase II, alpha-mannosidase II ... mannosidase, Golgi alpha-mannosidase II, ManII, 1,3(1,6)-alpha-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide alpha-D- ... Tulsiani DR, Hubbard SC, Robbins PW, Touster O (Apr 1982). "alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II ... Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior ...

*Mannan exo-1,2-1,6-alpha-mannosidase

... (EC 3.2.1.137, exo-1,2-1,6-alpha-mannosidase, 1,2-1,6-alpha-D-mannan D-mannohydrolase) is ... doi:10.1016/0304-4165(89)90069-x. Mannan exo-1,2-1,6-alpha-mannosidase at the US National Library of Medicine Medical Subject ... This enzyme catalyses the following chemical reaction Hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in yeast ... Takegawa, K.; Miki, S.; Jikibara, T.; Iwahara, S. (1989). "Purification and characterization of exo-α-D-mannosidase from a ...

*1,6-alpha-D-mannosidase

6-alpha-D-mannosidase (EC 3.2.1.163) is an enzyme that catalyzes the chemical reaction of separating the 1,6-linked alpha-D- ... The systematic name of this enzyme class is 1,6-alpha-mannosyl alpha-D-mannohydrolase. Athanasopoulos VI, Niranjan K, Rastall ... purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis". Carbohydr. Res. 340 (4): 609- ... mannose residues in alpha-D-Manp-(1->6)-D-Manp. This enzyme belongs to the family of hydrolases, specifically those ...

*Glycoprotein endo-alpha-1,2-mannosidase

... (EC 3.2.1.130, glucosylmannosidase, endo-alpha-D-mannosidase, endo-alpha-mannosidase, ... Glycoprotein endo-alpha-1,2-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... MANEA Lubas, W.A.; Spiro, R.G. (1987). "Golgi endo-α-D-mannosidase from rat liver, a novel N-linked carbohydrate unit ... This enzyme catalyses the following chemical reaction Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from ...

*Glycoside hydrolase family 47

... alpha-mannosidase (EC 3.2.1.113). Alpha-mannosidase is involved in the maturation of Asn-linked oligosaccharides. The enzyme ... "Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine- ... hydrolyses terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(glcnac)(2) in a calcium- ...

*Glycoside hydrolase family 38

... alpha-mannosidase (EC 3.2.1.24) (EC 3.2.1.114). Lysosomal alpha-mannosidase is necessary for the catabolism of N-linked ... non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave all known types of alpha-mannosidic linkages. ... The domain is predominantly found in the enzyme alpha-mannosidase. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, ... "The structure of bovine lysosomal alpha-mannosidase suggests a novel mechanism for low-pH activation". J. Mol. Biol. 327 (3): ...

*MAN2A1

"Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase ... Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene. This gene encodes a protein which is a member of ... "Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1". Land A, Braakman I (Aug 2001). "Folding of the human ... Moremen KW, Touster O, Robbins PW (Sep 1991). "Novel purification of the catalytic domain of Golgi alpha-mannosidase II. ...

*EDEM1

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene. GRCh38: Ensembl ... "Entrez Gene: EDEM1 ER degradation enhancer, mannosidase alpha-like 1". Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction ... 2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation". EMBO Rep. 2 (5): 415-22. doi:10.1093/ ...

*Swainsonine

Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core ... It is a potent inhibitor of Golgi alpha-mannosidase II, an immunomodulator, and a potential chemotherapy drug. As a toxin in ...

*Mannosidase

... is an enzyme which hydrolyses mannose. There are two types: alpha-Mannosidase beta-Mannosidase A deficiency is ... Mannosidases at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal. ... A family of mannosidases are also responsible for processing newly formed glycoproteins in the endoplasmic reticulum into ...

*Jamey Marth

"Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis ...

*MAN2B2

Epididymis-specific alpha-mannosidase precursor Mannosidase alpha class 2B member core-specific lysosomal alpha-1,6-Mannosidase ... epididymis-specific alpha-mannosidase mannosidase, alpha, class 2B, member GRCh38: Ensembl release 89: ENSG00000013288 - ... "Entrez Gene: MAN2B2 mannosidase, alpha, class 2B, member 2". Land A, Braakman I (2001). "Folding of the human immunodeficiency ... Epididymis-specific alpha-mannosidase is an enzyme that in humans is encoded by the MAN2B2 gene. ...

*MANEA

Glycoprotein endo-alpha-1,2-mannosidase is an enzyme that in humans is encoded by the MANEA gene. GRCh38: Ensembl release 89: ... Spiro MJ, Bhoyroo VD, Spiro RG (1997). "Molecular cloning and expression of rat liver endo-alpha-mannosidase, an N-linked ... MANEA mannosidase, endo-alpha". Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope ...

*MAN1A1

"Entrez Gene: MAN1A1 mannosidase, alpha, class 1A, member 1". Land A, Braakman I (2001). "Folding of the human immunodeficiency ... Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA is an enzyme that in humans is encoded by the MAN1A1 gene. This gene encodes ... 1997). "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning ... Bieberich E, Bause E (1995). "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II ...

*EDEM3

ER degradation-enhancing alpha-mannosidase-like 3 is an enzyme that in humans is encoded by the EDEM3 gene. GRCh38: Ensembl ... "Entrez Gene: EDEM3 ER degradation enhancer, mannosidase alpha-like 3". Maruyama K, Sugano S (1994). "Oligo-capping: a simple ...

*MAN1A2

"Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2". Land A, Braakman I (2001). "Folding of the human immunodeficiency ... Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene. GRCh38: Ensembl ... 2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585-95. doi:10.1093/glycob/8.6.585. PMID 9592125. " ...

*EDEM2

ER degradation-enhancing alpha-mannosidase-like 2 is an enzyme that in humans is encoded by the EDEM2 gene. GRCh38: Ensembl ... "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2". Andersson B, Wentland MA, Ricafrente JY, et al. (1996 ...

*MAN1B1

"Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1". Land A, Braakman I (2001). "Folding of the human immunodeficiency ... Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene ... Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 ... 2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585-95. doi:10.1093/glycob/8.6.585. PMID 9592125. ...

*Mannan 1,2-(1,3)-a-mannosidase

Mannan 1,2-(1,3)-alpha-mannosidase (EC 3.2.1.77, exo-1,2-1,3-alpha-mannosidase, 1,2-1,3-alpha-D-mannan mannohydrolase) is an ... Mannan 1,2-(1,3)-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... I. Purification and some properties of an α-mannosidase from an Arthrobacter species". J. Biol. Chem. 244: 1043-1051. PMID ... Mode of action of the Arthrobacter α-mannosidase on yeast mannan". J. Biol. Chem. 244: 1052-1059. PMID 5814027. ...

*Kifunensine

... shows no inhibitory action against mannosidase II or the endoplasmic reticulum alpha-mannosidase, and it weakly ... Kifunensine does not inhibit mannosidase II or the endoplasmic reticulum alpha-mannosidase. It weakly inhibits arylmannosidase ... Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki ... Kifunensine is a potent inhibitor of the mannosidase I enzyme. It is 50 to 100 times more potent than deoxymannojirimycin - an ...

*IDH2

Champion MJ, Brown JA, Shows TB (1979). "Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial ... a partially unraveled alpha helix in the semi open form, and an alpha helix in the active form. The mitochondrial form of IDH2 ... Its main function is to catalyze the oxidative decarboxylation of isocitrate into alpha-ketoglutarate. Human isocitrate ... NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and ...

*Bifidobacterium longum

In addition, B. longum can uniquely ferment galactomannan-rich natural gum using glucosaminidases and alpha-mannosidases that ...
Seeds of Triticale (hybrid of wheat and rye) contain an N-acetylglucosamine specific lectin that was affinity purified in our laboratory (Siva Kumar, N. and Padma, K. (1996) Affinity purification of N-acetyl glucosamine specific lectin. Purification and partial characterization of Triticale lectin. Biochem. Mol. Biol. Int. 38, 1059-1066). Seed extracts also exhibited alpha-mannosidase activity that was isolated by a combination of ion exchange, hydrophobic chromatography and gel filtration. The purified enzyme is a glycoprotein with 7% carbohydrate and exhibited a native molecular mass of 1,95,000 (+/-5000) on Biogel P-200 and dissociated into two major subunits under reducing conditions of molecular masses 58 and 40 kDa, respectively. Both subunits cross-reacted with an antibody to the well-characterized jack bean alpha-mannosidase, suggesting antigenic similarity between the legume and the cereal mannosidases. Purified enzyme binds to Con A-Sepharose gel, possibly through the sugar-binding site.
In eukaryotes, class I alpha-mannosidases are involved in early N-glycan processing reactions and in N-glycan-dependent quality control in the endoplasmic reticulum (ER). To investigate the role of these enzymes in plants, we identified the ER-type alpha-mannosidase I (MNS3) and the two Golgi-alpha-mannosidase I proteins (MNS1 and MNS2) from Arabidopsis thaliana. All three MNS proteins were found to localize in punctate mobile structures reminiscent of Golgi bodies. Recombinant forms of the MNS proteins were able to process oligomannosidic N-glycans. While MNS3 efficiently cleaved off one selected alpha 1,2-mannose residue from Man(9)GlcNAc(2), MNS1/2 readily removed three alpha 1,2-mannose residues from Man(8)GlcNAc(2). Mutation in the MNS genes resulted in the formation of aberrant N-glycans in the mns3 single mutant and Man(8)GlcNAc(2) accumulation in the mns1 mns2 double mutant. N-glycan analysis in the mns triple mutant revealed the almost exclusive presence of Man(9)GlcNAc(2), ...
1PS3: Comparison of Kifunensine and 1-Deoxymannojirimycin Binding to Class I and II alpha-Mannosidases Demonstrates Different Saccharide Distortions in Inverting and Retaining Catalytic Mechanisms
Gentaur molecular products has all kinds of products like :search , SibEm \ Mnl I \ E482 for more molecular products just contact us
A, ricin resistance of ricin-selected cell lines. Individual cell lines were treated with graded doses of ricin for 4 h, and their subsequent ability to synthesize proteins was determined. Blue, parental HEK 293T (n = 24);open circles and dotted lines, HEK 293S Lec1 (n = 4); gray (n= 1-4), orange (n = 1, 2, 3, or 6), violet (n = 1-3), and green (n = 6 or 7) indicate cell lines belonging to various selection screen-defined classes. Error bars have been omitted for clarity. B, nonselected sensitivity of all of these cell lines to PEx. Cell lines were treated with graded doses of PEx for 4 h, and their subsequent ability to synthesize proteins was determined. Blue (n = 10), open circles (n = 2), gray (n = 1-4), violet (n = 1 or 3), and green(n = 3) are same as in A; orange (n = 1-5) indicates cells with ∼5-fold or greater resistance to PEx. Error bars have been omitted for clarity. C, scatter plot of PEx resistance versus ricin resistance for all of the cell lines generated. Sensitivity of the ...
[39 Pages Report] Check for Discount on Alpha-Mannosidosis Global Clinical Trials Review, H2, 2016 report by GlobalData. GlobalDatas clinical trial report,
Cytosolic α-mannosidases are glycosyl hydrolases that participate in the catabolism of cytosolic free N-oligosaccharides. Two soluble α-mannosidases (E-I and E-II) belonging to glycosyl hydrolases family 47 have been described in Candida albicans. We demonstrate that addition of pepstatin A during the preparation of cell homogenates enriched α-mannosidase E-I at the expense of E-II, indicating that the latter is generated by proteolysis during cell disruption. E-I corresponded to a polypeptide of 52 kDa that was associated with mannosidase activity and was recognized by an anti-α1,2-mannosidase antibody. The N-mannan core trimming properties of the purified enzyme E-I were consistent with its classification as a family 47 α1,2-mannosidase. Differential density-gradient centrifugation of homogenates revealed that α1,2-mannosidase E-I was localized to the cytosolic fraction and Golgi-derived vesicles, and that a 65 kDa membrane-bound α1,2-mannosidase was present in endoplasmic reticulum and Golgi
1TQW: Insights into the Mechanism of Drosophila melanogaster Golgi a-Mannosidase II Through Crystallographic Analysis of the Interactions with Analogues of the Naturally Occurring Glycomimetic Salacinol
Outside, Inside - Early this morning, I took time to walk around the garden in Kuching and did a couple of clearing up job at the side garden especially areas along the sout... ...
Laman ini diujudkan buat anda yang mencari kaedah ubatan herba alam semulajadi untuk sakit barah, selain berkongsi pendapat dan pengalaman sesama ahli. Menyedari faktor penyebab barah selain mengelak penipuan kerana pesakit barah selalu ditipu oleh orang yang rakus mengaut untung semata-mata. Laman ini juga bertujuan menyingkap amalan buruk yang merugikan kita.. ...
Top XXX Cam Girls Ultimate Guide to ... We have have reviewed every single live sex cam site that has over 10 girls live at ... Take a look at the web cam girls that ...
Lokasi Pemutaran & Waktu: OMAH APIK, Pejeng Senin/Mon 12 Oktober 2015, jam 20:00 - 21:00 WITA SIKUNO, Denpasar Sabtu/Sat 17 Oktober 2015, jam 19:45 - 20:45 WITA Kurator: Oggs Cruz Durasi ...
Pengguna mengharapkan laman berjalan mulus dan interaktif. Setiap tahap di pipeline piksel menyatakan peluang timbulnya jank. Pelajari tentang alat dan strategi untuk mengidentifikasi dan memperbaiki masalah umum yang memperlambat kinerja waktu proses.
Hakcipta Terpelihara. Dilarang mengeluar ulang atau menggunakan mana-mana kandungan laman ini dalam apa jua bentuk dan apa jua cara sama ada elektronik, cetak, mekanik, fotokopi, rakaman atau pengstoran maklumat termasuk sistem dapat kembali tanpa mendapat kebenaran bertulis pemilik hakcipta. ...
ISSN: 2302-8254 Laman Web: http://jfa.ffarmasi.unand.ac.id/ Email: Alamat email ini dilindungi dari robot spam. Anda memerlukan Javascript yang aktif...
Ini laman tidak formal untuk mendekatkan pelajar-pelajar MRSM Kuantan serta bekas-bekas pelajar dengan institusi pendidikan yang menjadi perkebunan ilmu mereka sepanjang pengajian mereka di sini. ...
These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.. Check out our Research Gallery. ...
β-mannosidase (EC 3.2.1.25, MANB) dissects the non-reducing end of N-linked mannose moieties of glycoproteins in eukaryotic cells. The human β-mannosidase gene was amplified by RT-PCR, cloned and sequenced. The DNA sequence was compared with reported human β-mannosidase DNA sequence and sixteen nucleotide differences were found. The deduced amino-acid sequence showed that seven codons coded the same amino acids and nine codons coded different amino acids with reference to nucleotide substitution positions but did not affect recombinant MANB enzyme activity. No splice mutation was observed after comparison with reported MANB DNA sequences. A 75% homology of deduced amino-acid sequence was observed with mouse, goat and bovine β-mannosidase amino-acid sequences. The cloned β-mannosidase gene was subcloned into pET22b+ and pET28a+ expression vectors to transform the BL21-codon plus cells for expression of recombinant MAN22 and MAN28 enzymes, respectively. The optimized conditions for ...
Reka Bentuk Grafik & Reka Bentuk Laman Web Projects for $50 - $300. Im looking for Experienced E-commerce website developer to develop a simple & friendly to use website for ease matching homecooked food by location. It should not have too much left and right side co...
PHP & Reka Bentuk Laman Web Projects for $. Hi, I would like a social network to be either 1.) Custom built or 2.) Created using Boonex Dolphin as the base. If it is the first option then I would like the site to have the following features: ...
Diseases caused by the loss of one or more enzymes involved in the hydrolysis of mannoside linkages (MANNOSIDASES). The defects in enzyme activity are primarily associated with genetic mutation of the genes that codes for a particular mannosidase isoenzyme ...
Maybe .. . . you should dream what you want to dream; go where you want to go, be what you want to be, because you have only one life and one chance to do all the things you dream of, and want to do. "Life is only travelled ONCE; Todays MOMENT becomes Tomorrows MEMORY. Enjoy every moment, good or bad, because the GIFT of LIFE is LIFE itself…." ...
PENAFIAN: Ini adalah laman blog sokongan untuk tujuan PROMOSI sahaja. Tiada kaitan dengan laman web syarikat yang disertai. Contoh pendapatan adalah simulasi sahaja. Pendapatan sebenar bergantung kepada usaha setiap peserta. Saya tidak menjamin sebarang pendapatan TETAP. Tiada mana-mana bahagian portal ini boleh diubah, disalin, diedar, dihantar semula, disiarkan, dipamerkan, diterbitkan, dilesenkan, dipindah, dijual atau diuruskan bagi tujuan komersil dalam apa bentuk sekalipun tanpa mendapat kebenaran secara bertulis yang jelas terlebih dahulu daripada ADMIN . Admin bukalah pengamal perubatan dan tiada mana-mana artikel di dalam blog ini dapat menyokong penyembuhan secara total ...
Produk yang disebut dalam blog/laman web ini tidak boleh digunakan untuk tujuan diagnosis, merawat, menyembuh atau mencegah sebarang penyakit.. Maklumat dalam blog/laman web ini tidak boleh digunakan sebagai pengganti rawatan perubatan dan konsultasi doktor atau pakar pemakanan mahupun dianggap sebagai preskipsi. Sesiapa yang percaya bahawa mereka mengalami sebarang jenis penyakit atau masalah kesihatan, sila berjumpa dengan doktor berkaitan untuk diagnosis dan rawatan susulan. ...
Produk yang disebut dalam blog/laman web ini tidak boleh digunakan untuk tujuan diagnosis, merawat, menyembuh atau mencegah sebarang penyakit.. Maklumat dalam blog/laman web ini tidak boleh digunakan sebagai pengganti rawatan perubatan dan konsultasi doktor atau pakar pemakanan mahupun dianggap sebagai preskipsi. Sesiapa yang percaya bahawa mereka mengalami sebarang jenis penyakit atau masalah kesihatan, sila berjumpa dengan doktor berkaitan untuk diagnosis dan rawatan susulan. ...
In terms of performance, users should keep in mind that the warm-up time during a power failure, pull down time, uniformity a ...
Sayuan hijau ini agak mahal jugak jika dibeli dipasar…selalunya lebih dari RM1.00++. Kita boleh mengurangkannya dengan menanamnya sendiri. Tak perlu ada laman besar tak perlu beli pasu mahal-mahal. Cuma perlukan sedikit "potting soil" dan guna semula "bekas terbuang", kita mampu sediakan stok sayuran ini sepanjang masa ...
blog seribupilihan memaparkan artikel berkenaan info-info dunia,agama,kesihatan,perubatan,tip dan kecantikan,perhubungan,sukan,bisnes,iklan promosi,buah-buahan,cerita lawak,jenaka,cinta,destinasi dan pelancongan,fakta,fesyen,gambar dan lukisan,hiasan,laman,haiwan,ibubapa,intim,isu semasa,kecantikan,kecergasan,kenderaan,makanan,minuman,masyarakat,pantun,peribahasa,politik,renungan,kehidupan,sains,kajian,santai minda,sejarah,selebriti,tanaman,herba,teknologi,gajet,ucapan,video,wanita,www, http
The animals involved in the study are born with a genetic disorder directly analogous to alpha-mannosidosis or AMD, an inherited disease in humans that causes severe mental retardation and skeletal abnormalities. Cats with AMD do not live more than six months. Children born with the worst form of the disease rarely survive into their teens. "Through gene therapy, we replace a broken gene responsible for alpha-mannosidase with the correct, functioning copy, to dramatic results," said John H. Wolfe, a professor of pathology and medical genetics at the Penn School of Veterinary Medicine and a neurology researcher at Children s Hospital. "The treated cats were markedly improved compared to diseased cats, with better balance and muscle control and fewer tremors ...
A recent study in Genetics in Medicine aiming at the identification by whole-exome sequencing of genes involved in infantile nystagmus found heterozygous missense mutations in the MANBA gene, which the encodes lysosomal beta-mannosidase. The mutations resulted in decrease of ?-mannosidase activities in the patients as well as in mutant-transfected HEK293T cells. MANBA is expressed in the pretectal nucleus of the developing midbrain, […]. ...
These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.. Check out our Research Gallery. ...
These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.. Check out our Research Gallery. ...
NORDIN, JH and Kunkel, JG, "SIZE HETEROGENEITY OF THE HIGH MANNOSE OLIGOSACCHARIDES OF INSECT VITELLINS" (1982). FEDERATION PROCEEDINGS. 316 ...
TY - JOUR. T1 - Cobalt ions cross an electrotonic synapse if cytoplasmic concentration is low. AU - Politoff, A.. AU - Pappas, G. D.. AU - Bennett, Michael V. L.. PY - 1974/8/16. Y1 - 1974/8/16. UR - http://www.scopus.com/inward/record.url?scp=0016138697&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0016138697&partnerID=8YFLogxK. U2 - 10.1016/0006-8993(74)90466-1. DO - 10.1016/0006-8993(74)90466-1. M3 - Article. C2 - 4844459. AN - SCOPUS:0016138697. VL - 76. SP - 343. EP - 346. JO - Brain Research. JF - Brain Research. SN - 0006-8993. IS - 2. ER - ...
PERHATIAN: Ini adalah laman web peribadi. Tiada kaitan dengan Syarikat MLM yang disertai. Tujuan laman web ini disediakan adalah bagi membantu ahli-ahli yang berdaftar di bawah kumpulan AHB Cordyceps4u untuk membuat promosi menaja ahli-ahli yang baru. Promosi boleh dilakukan secara online dan juga offline serta terpulang kepada kreativiti anda ...
Teringat dulu saya hampir terlupa tentang ini..bukan tidak tahu tapi jarang diamalkan oleh masyarakat Malaysia termasuklah saya..jadi sebelum makan ubat baca bismillah dan doa. Saya tersedar ketika menghadiri satu kuliah agama di mana ustaz tu mengingatkan kembali pergantungan kita kepada Allah. Ustaz kata bagusnya kalau pergi di mana sahaja semua mengingatkan kita kepada Allah, seperti kos farmasi ketika nak bagi ubat kat pesakit, perlu cakap Allah yang menyembuhkan,ubat ini sebagai usaha kita, kos kejuteraan contohnya kejuteraan mekanikal..mesin dicipta mendapat perhatian seluruh dunia bagi memudahkan pekerjaan manusia seharian tetapi pencipta mesin iaitu jurutera itu berkata pada wartawan atau pada seluruh ummat bahawa mesin yang dicipta tak dapat menandingi kehebatan Allah dan bidang kejuruteraan kimia membuktikan zarah-zarah di udara bergerak membentuk kalimah Allah, begitu juga air yang bila mana dibaca kalimah yang baik seperti kalimah Allah terhasillah rupa bentuk zarah air yang indah ...
Meletakkan hukum syariat yang berlaku bagi semua manusia dalam bidang ibadah, muamalah dan segenap urusan mereka, memutuskan persengketaan dan perseteruan di antara mereka adalah hak mutlak Allah Taala sebagai pencipta manusia. Allah Taala berfirman, "Ingatlah, menciptakan dan memerintah hanyalah hak Allah." (Al-Araf: 59).. Sebagai pencipta, secara otomatis Allah mengetahui ciptaanNya, Allah mengetahui manusia sebagai hambaNya, apa yang baik dan apa yang buruk bagi mereka, sehingga Dia meletakkan tatanan dan aturan sebagai konsekuensi dari rububiyahNya dan manusia patut menerima tatanan dan aturan tersebut sebagai tuntutan dari penghambaan dan demi kemaslahatan mereka sendiri.. "Tentang sesuatu apapun kamu berselisih, maka putusannya (terserah) kepada Allah. Itulah Allah Tuhanku, kepadaNya lah aku bertawakkal dan kepadaNyalah aku kembali." (Asy-Syura: 10).. Karena hak menetapkan syariat hanya di tangan Allah, maka tidak pantas bagi siapa pun untuk mengakui hak tersebut, baik dengan ...
Ini website bolasepak Indie dan ditulis dengan nada sinis dan humor. Kalau rasa sakit bontot team korang kena menganjing pasal dah 2 dekad tak menang liga sila ke SANDARKANPADAKENANGAN.COM. Kalau sakit bontot pasal team korang kena maki team kanak-kanak Taski Wenger sila la ke website lain juga. Kalau nak serius jugak sila angkat kaki, jalan terus ,belok kiri le lepas tu sila pergi mampos ...
Perkataan Millat adalah bahasa Urdu yang biasa digunakan untuk merujuk kepada negara. Laman web itu sudah mempunyai 4,300 ahli selepas tiga hari dilancarkan, kebanyakannya warga Pakistan yang boleh berbahasa Inggeris dalam lingkungan usia 20-an ...
Perkataan Millat adalah bahasa Urdu yang biasa digunakan untuk merujuk kepada negara. Laman web itu sudah mempunyai 4,300 ahli selepas tiga hari dilancarkan, kebanyakannya warga Pakistan yang boleh berbahasa Inggeris dalam lingkungan usia 20-an ...
Edit 31/10/2012 : Gara-gara post ni yang bertajuk Seriusss..rinduuu ada yang bertanya .. dengan siapa CF bercinta? hahaha gelak bes00 CF dibuatnyee.. bercinta dengan BLOG ni lah.. blog ni lah terapi buat CF.. suka duka bersama.. hari ni 800 post dah terhasil di laman blog ni .. semoga kita dapat berkongsi ilmu bersama ...
Admin blog ini tidak akan bertanggungjawab ke atas sebarang kerugian, kehilangan atau kerosakan yang dialami dalam penggunaan sebarang maklumat yang dicapai daripada laman blog ini. Terima kasih. ...
Pemilik blog ini tidak bertanggungjawab sekiranya berlaku kerosakan atau masalah pada system komputer pelawat semasa/sesudah melawat laman ini. Juga tidak akan bertanggungjawab terhadap kerosakan hartabenda pelawat sekiranya pelawat mencuba tutorial atau apa apa sahaja yang dipersembahkan dalam blog ini. Segala tulisan dan pandangan dalam blog ini adalah telus. Segala artikel2 atau bahan2 info adalah dipetik dari berbagai2 sumber dan disiarkan sebagai rujukan semata mata.Penulis terlebih dahulu memohon ampun dan maaf sekiranya ada antara artikel atau tulisan yang menyentuh/menganggu emosi para pelawat. Ucapan terima kasih kepada pihak sumber kerana segala rujukan adalah amat bermanafaat kepada kami , Peminat Pertanian ...
Pemilik blog ini tidak bertanggungjawab sekiranya berlaku kerosakan atau masalah pada system komputer pelawat semasa/sesudah melawat laman ini. Juga tidak akan bertanggungjawab terhadap kerosakan hartabenda pelawat sekiranya pelawat mencuba tutorial atau apa apa sahaja yang dipersembahkan dalam blog ini. Segala tulisan dan pandangan dalam blog ini adalah telus. Segala artikel2 atau bahan2 info adalah dipetik dari berbagai2 sumber dan disiarkan sebagai rujukan semata mata.Penulis terlebih dahulu memohon ampun dan maaf sekiranya ada antara artikel atau tulisan yang menyentuh/menganggu emosi para pelawat. Ucapan terima kasih kepada pihak sumber kerana segala rujukan adalah amat bermanafaat kepada kami , Peminat Pertanian ...
Blog ini adalah hak milik peribadi saya dan tidak ditaja oleh mana-mana warga persendirian, organisasi, mahupun pihak ketiga.. Penafian: Laman web ini tidak bertujuan untuk menggantikan nasihat profesional, diagnosis, atau rawatan oleh pakar perubatan berlesen. Produk Shaklee tidak bertujuan untuk membuat diagnosis, merawat, menyembuh atau mencegah sebarang penyakit. Jika anda memerlukan sebarang nasihat berkaitan perubatan, hubungi doktor anda dengan segera.. ...
Searching for $900-$1000 Safety Storage products? Graingers got your back. Easy ordering & convenient delivery. Log-in or register for your pricing.
When it comes to Safety Storage products, Graingers got your back. Effortless ordering and convenient delivery. Log-in or register for your pricing.
Buy Nappies Wipes & Bathroom Baby Wipes Wipes Storage Products. The Best Value Products Available at ThePharmacy. Call us 1300 843 742
Buah ni dari pokok hutan yang tak dikenal pasti apa spesiesnya.Saudara aku cakap,dia nampak buah ni tergantung kat pokok durian dia.Dia pun curious juga,so dia kait buah ni.Pokok asal buah ni adalah jenis menjalar(vine).Walaupun buahnya tak betul-betul bulat,tapi berat.Lebih kurang 4-5kg juga dan lebar sekitar 1 kaki ...
adalah normal bila bayi selsema, akan datang pakej batuk dan demam sekali. kalau yang kuat sikit antibodinya, tak demam lah.. just batuk dan selsema.. itupun dah cukup buat ibu2 rasa gundah gulana bila baby kita tercungap2 nak bernafas, mukus tak berhenti mengalir (lambat lap dah jilat2 dah..hihi), dan batuk kong kong siang malam.. bila dah macam gitu keadaan baby, mestilah baby susah nak tidur.. bila baby tak lena tidur, kita pun tak lena tidur juga, betul tak? . baby Nailah saya (anak ke 3 saya), baru2 ni di serang selsema yang agak lama. sebelum ni pernah jugak selsema.. tapi sehari 2 dah sembuh sepenuhn ...
5. Saya tidak akan bertanggungjawab di atas barang yang rosak atau hilang ketika proses pengeposan.. 6. ChocoBeau mempunyai hak untuk menukar tarikh pesanan, awal atau lewat. Juga, saya memegang hak untuk membuat perubahan dasar laman web dan T & C pada setiap masa.. 7. PENTING!! Item ready stok bermaksud item sedia ada. Manakala, PREORDER bermaksud perlu membuat tempahan dahulu dari kilang. Item pre-order mengambil masa lebih kurang 3 ke 4 minggu untuk sampai.Sekiranya anda mempunyai tahap kesabaran yang rendah, tidak digalakkan untuk membuat pesanan dari PRE-ORDER item.. 8. Pembayaran harus dilakukan ke akaun MAYBANK dan CIMB. Tiada COD dibenarkan, kecuali anda mengambil pesanan anda di rumah.. 9. Pesanan akan dipos sekirannya anda selesai membuat pembayaran. 10. Kami mempunyai 1 hari return policy dengan bersyarat, iaitu item yang anda order rosak atau koyak bukan disebabkan oleh kecuaian anda.Sebelum memulangkan item tersebut, sila menghubungi kami untuk mengesahkan status item anda. ...
Sigma-Aldrich offers Sigma-N2127, 4-Nitrophenyl α-D-mannopyranoside for your research needs. Find product specific information including CAS, MSDS, protocols and references.
IBM Spectrum Storage Suite helps you improve the way you manage data with a bundled suite of software-defined storage products at a cost-effective price
Apolipoproteins are carrier proteins that bind lipids to form water-soluble lipoprotein particles that can be carried through blood and lymph. Several different classes and subclasses of apolipoproteins are known. Apolipoprotein B (ApoB) is the primary apolipoprotein in chylomicrons (lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins) and low-density lipoprotein (LDL). It is also known as FLDB and LDLCQ4. High levels of ApoB can lead to plaques that cause atherosclerosis, and ApoB levels can be a better indicator of heart disease risk than total cholesterol or LDL. The APOB transcript is subject to tissue-specific RNA editing, resulting in two major isoforms, ApoB-100 and ApoB-48.. ...
The following D. discoideum glycosidases were studied: beta-hexosaminidase (EC 3.2.1.30 and EC 3.2.1.17), alpha-mannosidase (EC 3.2.1.24), beta-glucosidase (EC 3.2.1.21), beta-galactosidase (EC 3.2.1.23) and alpha-glucosidase (EC 3.2.1.20) or glucoamylase (EC 3.2.1.3). beta-hexosaminidase and beta-glucosidase were purified to greater than 90% homogeneity, alpha-mannosidase was purified to two protein components both with enzymic activity; whereas alpha-glucosidase and beta-galactosidase could not be separated and the purified preparation contained several components. The biochemical and biophysical properties of the purified enzymes are described. Antibodies against these enzymes were prepared and the immunological properties of purified and crude samples of glycosidases from various stages of the slime mould life-cycle were examined. These antibody preparations were used as tools to isolate isotopically labelled enzymes from crude extracts in experiments which show that beta-hexosaminidase and ...
K01186 NEU1; sialidase-1 [EC:3.2.1.18] K01186 NEU1; sialidase-1 [EC:3.2.1.18] K01190 lacZ; beta-galactosidase [EC:3.2.1.23] K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] K01227 E3.2.1.96; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96] K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51 ...
Rasa2nya dah kurang efektif guna blok ni tapi rupa2nya ada pula orang lain yang sempat bagi iklan melalui laman ini. Aku pula memang tak buka sangat benda ni dah. Tapi bila rasa2nya nak masukkan post utk personal blog (J), baru tertengok. Wah memang banyak la. So terpaksa la aku hanya membenarkan registered users saja utk bagi komen lepas ni. Apa2 pun bagi korang yang memang layan laman ni . . thanks dan teruskan usaha murni korang tu ...
Jakarta - Humas BKN, Kepala Badan Kepegawaian Negara (BKN) Bima Haria Wibisana sesaat setelah memonitor langsung proses pendaftaran penerimaan Calon Pegawai Negeri Sipil (CPNS), mengimbau kepada masyarakat agar pendaftaran dapat dilakukan hanya melalui portal https://sscn.bkn.go.id/. Hal itu dikarenakan, pasca dibukanya pendaftaran penerimaan CPNS pada Senin, (1/8/2017), pukul 10.00 WIB, masih banyak masyarakat yang mengakses laman www.bkn.go.id, sehingga berakibat pada performa laman tersebut yang menurun ...
Dental Product Shopper delivers practical, unbiased product information. Our peer to peer product reviews help you select the best products for your practice.
Baru semalam saya tulis berkenaan dengan harga dynamo 4.7 kg. Harga biasa di pasaran RM23.99. Hari ini, saya dapat flyer dari The Store Pacific: Harga Jualan: RM19.99 Tarikh Promosi: 20 - 22 Ogos 2010 Terhad kepada 2 botol setiap pelanggan. Rujuk laman web The Store untuk lebih lanjut.
Volume 78, Issue 3, September 2015, Pages: 343-354, Ruth Huizinga, Bianca van den Berg, Wouter van Rijs, Anne P. Tio-Gillen, Willem Jan R. Fokkink, Liesbeth E. Bakker-Jonges, Karin Geleijns, Janneke N. Samsom, Pieter A. van Doorn, Jon D. Laman and Bart C. Jacobs. Version of Record online : 30 JUN 2015, DOI: 10.1002/ana.24442. ...
Link ini adalah untuk pelanggan setia kami sahaja Jika anda adalah pelanggan yang regular, sila ke laman ini untuk melihat stok baru kami.. Ini bertujuan menjaga pattern terbaru dari ditiru oleh pihak tidak bertanggungjawab..terima kasih. ...
Bagi memudahkan proses wakaf Telekung ini, KJ 1986 Buddies melalui laman Facebook kami (Puan Wawa Biz, Fifa Haziq, Seri Dewi) akan memproses pembelian Telekung daripada orang ramai bagi diwakafkan seterusnya menghantar telekung yang diwakafkan itu kepada mana-mana Masjid atau Surau yang dipilih oleh pewakaf ...
Synthesis of p-Isothiocyanatophenyl 3-O-(3,6-Dideoxy-alpha-D-xylo-hexopyranosyl)-alpha-D-mannopyranoside.. Eklind, Karin; Garegg, Per J.; Gotthammar, Birgitta ...
α-Mannosidosis (MIM 248500) is an autosomal recessive lysosomal storage disorder resulting from deficient activity of lysosomal α-mannosidase (LAMAN) (EC 3.2.1.24). The disease is characterized by massive intracellular accumulation of mannose-rich oligosaccharides with resulting mental retardation, hearing loss, immune deficiency and skeletal changes. We report here the purification and characterization of human placenta LAMAN. The enzyme is synthesized as a single-chain precursor which is processed into three glycopeptides of 70, 42 and 15 kDa. The 70 kDa peptide is further partially proteolysed into three more peptides that are joined by disulfide bridges. The laman cDNA sequence was assembled from overlapping fragments obtained by PCR on human fibroblast and human lung cDNA. The deduced amino acid sequence contains a putative signal peptide of 48 amino acids followed by a polypeptide sequence of 962 amino acids. Northern blot analyses revealed a single transcript of ∼3.5 kb present in all ...
Sila ambil perhatian bahawa kanak-kanak di bawah umur 18 tahun ("Kanak") hendaklah disertai dengan ibu bapa, penjaga menurut undang-undang dan/atau wakil yang berkenaan ketika melawati atau melayari Laman Web atau Halaman TAS dan/atau mengguna perkhidmatan yang terdapat di Laman Web dan Halaman TAS tersebut. Di mana ibu bapa, penjaga menurut undang-undang dan/atau wakil yang berkenaan telah membenarkan Kanak untuk melawati atau melayari Laman Web dan Halaman TAS, dan/atau menggunakan mana-mana perkhidmatan yang disediakan di Laman Web dan Halaman TAS, ibu bapa, penjaga menurut undang-undang dan/atau wakil yang berkenaan akan bertanggungjawab sepenuhnya untuk ...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
PERHATIAN: Ini adalah laman web peribadi. Tiada kaitan dengan Syarikat MLM yang disertai. Tujuan laman web ini disediakan adalah bagi membantu ahli-ahli yang berdaftar di bawah kumpulan AHB Cordyceps4u untuk membuat promosi menaja ahli-ahli yang baru. Promosi boleh dilakukan secara online dan juga offline serta terpulang kepada kreativiti anda ...
PERHATIAN: Ini adalah laman web peribadi. Tiada kaitan dengan Syarikat MLM yang disertai. Tujuan laman web ini disediakan adalah bagi membantu ahli-ahli yang berdaftar di bawah kumpulan AHB Cordyceps4u untuk membuat promosi menaja ahli-ahli yang baru. Promosi boleh dilakukan secara online dan juga offline serta terpulang kepada kreativiti anda ...
Ribuan kertas penyelidikan rakyat Malaysia telah dibentang dan diterbitkan, tetapi sering sukar diperolehi secara terus. Khalayak penyelidik, akademik dan universiti sangat memerlukan kertas-kertas tersebut boleh dirujuk, dalam e-format dan berada di laman web. Ilmu yang sangat bermanfaat ialah yang boleh dirujuk dan dipelajari terus. Bangsa yang menawarkan penyelidikan mereka yang mudah diperolehi pastinya akan berada di hadapan berbanding kerja-kerja yang tersimpan dalam almari-almari dan rak-rak buku.Hakmilik kertas-kertas penyelidikan di sini adalah milik sepenuhnya pengarang kertas berkenaan. Kami hanya mengiklankan dan menyambungkan di mana ia berada.Kami memerlukan sokongan tuan-tuan. Jika tuan-tuan sedang membuat usaha yang sama, sila maklumkan atau sila email url kertas tuan-tuan ke [email protected] Kita memerlukan rantaian pengkalan data yang meluas.Malah jika tuan-tuan berminat untuk belajar di peringkat Master by research atau PhD, sila hubungi mereka ini." Terima kasih. publicma ...
Ribuan kertas penyelidikan rakyat Malaysia telah dibentang dan diterbitkan, tetapi sering sukar diperolehi secara terus. Khalayak penyelidik, akademik dan universiti sangat memerlukan kertas-kertas tersebut boleh dirujuk, dalam e-format dan berada di laman web. Ilmu yang sangat bermanfaat ialah yang boleh dirujuk dan dipelajari terus. Bangsa yang menawarkan penyelidikan mereka yang mudah diperolehi pastinya akan berada di hadapan berbanding kerja-kerja yang tersimpan dalam almari-almari dan rak-rak buku.Hakmilik kertas-kertas penyelidikan di sini adalah milik sepenuhnya pengarang kertas berkenaan. Kami hanya mengiklankan dan menyambungkan di mana ia berada.Kami memerlukan sokongan tuan-tuan. Jika tuan-tuan sedang membuat usaha yang sama, sila maklumkan atau sila email url kertas tuan-tuan ke [email protected] Kita memerlukan rantaian pengkalan data yang meluas.Malah jika tuan-tuan berminat untuk belajar di peringkat Master by research atau PhD, sila hubungi mereka ini." Terima kasih. publicma ...
Merupakan sejenis pokok kecil nam nam merupakan antara tumbuhan yang dijadikan hiasan laman di kampung-kampung di pantai timur dan kawasan utara di Malaysia. ia memerlukan kawasan yang bersaliran baik dengan sinaran matahari yang cukup untuk tumbuh subur. Buahnya yang berwarna coklat dengan permukaan yang berkerutu boleh dimakan. rasanya masam kelat ketika muda dan akan berubah menjadi masam manis apabila masak.
Judul asliKatak Pinokio Spesies Baru dari Papua JAKARTA, KOMPAS.com - Sebuah ekspedisi ilmiah menemukan sejumlah spesies baru di Pegunungan Foja, di Pulau Guinea Baru, Provinsi Papua. Salah satunya jenis katak baru yang pantas disebut katak Pinokio karena memiliki bagian tubuh memanjang di mukanya. Photo: Tim Laman/National Geographic Spesies baru itu yakni katak (Litoria sp nov)…
Hakcipta Terpelihara (C) 2008++ oleh Amiene Rev. Tidak dibenarkan diterbitkan semula untuk tujuan komersial mana-mana bahagian terbitan ini dalam apa jua bentuk sama ada secara elektronik, mekanikal, disalin semula atau sebaliknya tanpa izin pemilik blog Duke Amiene Rev, iaitu Amiene Rev. Sekiranya terlanjur mengeluarkan apa-apa bahan di dalam blog ini, maka hendaklah dikreditkan kepada nama Amiene Rev sebagai penulis/pengkarya dan pautan laman blog ini, iaitu http://dukeamienerev.blogspot.com sebagai sumber asal. Bagi penerbitan yang bersifat komersil, individu atau pihak terbabit hendaklah membayar royalti kepada Amiene Rev bagi setiap karya atau tulisan yang disiarkan di penerbitan tersebut ...
Dan jika gua bukan manusia, apakah lu sebenarnya? Lu boleh marah kalau lu follow blog ni, tp gua tak follow lu balik. Tu hak gua, salah seorang yang hidup bawah langit demokrasi. Motif gua berjima dengan laman sesawang ni pun adalah sebagai diari yg kelak gua tua gua dapat ingat kembali memori masa gua muda :) .Gua bangga dengan Diaridosa yang tak seberapa ini, kerana Diaridosa inilah sejujur-jujur hati gua. Achtung, gua selalu menipu di realiti tp penulisan gua bukan begitu. Gua tak harap orang follow, gua cuma nak menulis. Terimakasih kepada pembaca yang setia. \m ...
Hampir keseluruhan artikel ataupun catatan di dalam blog ini ditulis sendiri oleh Sagahayat berpandukan bahan rujukan buku, majalah, emel, rancangan televisyen, akhbar, laman web dan sebagainya. Kembara, rekreasi dan pengalaman pula ditulis berdasarkan pengalaman Sagahayat sendiri. Fakta yang ditulis dan diterbitkan tidak sama sekali dipesong. Kisah benar pula ditulis dan diolah suai mengikut imaginasi penulis tanpa sama sekali mengubah rentetan cerita atau fakta yang terdapat dalam artikel itu. Sekiranya anda terbaca catatan yang boleh dikatakan diplagiat daripada blog anda, anda berhak menghubungi saya di emel [email protected] supaya saya dapat membuang atau mengedit catatan tersebut. Terima kasih ...
Hakcipta Terpelihara (C) 2008++ oleh Amiene Rev. Tidak dibenarkan diterbitkan semula untuk tujuan komersial mana-mana bahagian terbitan ini dalam apa jua bentuk sama ada secara elektronik, mekanikal, disalin semula atau sebaliknya tanpa izin pemilik blog Duke Amiene Rev, iaitu Amiene Rev. Sekiranya terlanjur mengeluarkan apa-apa bahan di dalam blog ini, maka hendaklah dikreditkan kepada nama Amiene Rev sebagai penulis/pengkarya dan pautan laman blog ini, iaitu http://dukeamienerev.blogspot.com sebagai sumber asal. Bagi penerbitan yang bersifat komersil, individu atau pihak terbabit hendaklah membayar royalti kepada Amiene Rev bagi setiap karya atau tulisan yang disiarkan di penerbitan tersebut ...
FalakOnline. Segala maklumat yang dipaparkan di dalam laman web ini adalah hak milik peribadi penulisnya Shahrin Ahmad. Sebarang salinan samada dalam bentuk hardcopy atau softcopy tidak dibenarkan melainkan mendapat kebenaran terus daripada beliau. Namun, penulis sentiasa menggalakkan perkongsian maklumat yang beretika dan atas dasar meraikan ilmu yang benar. Penulis boleh dihubungi di sini.. ...
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008 ...
Racine, WI www.scjohnson.com Sales: $10 billion, but that total includes food storage products. Key Personnel: Fisk Johnson, chairman and ch
Congenital disorders of glycosylation comprise a group of genetic defects with a high frequency of intellectual disability, caused by deficient glycosylation of proteins and lipids. The molecular basis of the majority of the congenital disorders of glycosylation type I subtypes, localized in the cytosol and endoplasmic reticulum, has been solved. However, elucidation of causative genes for defective Golgi glycosylation (congenital disorders of glycosylation type II) remains challenging because of a lack of sufficiently specific diagnostic serum methods. In a single patient with intellectual disability, whole-exome sequencing revealed MAN1B1 as congenital disorder of glycosylation type II candidate gene. A novel mass spectrometry method was applied for high-resolution glycoprofiling of intact plasma transferrin. A highly characteristic glycosylation signature was observed with hybrid type N-glycans, in agreement with deficient mannosidase activity. The speed and robustness of the method allowed ...
The oligosaccharidoses (glycoproteinoses) are a subset of lysosomal storage disorders caused by the deficiency of any one of the lysosomal enzymes involved in the degradation of complex oligosaccharide chains. They are characterized by the abnormal accumulation of incompletely degraded oligosaccharides in cells and tissues and the corresponding increase of related free oligosaccharides in the urine. Clinical diagnosis is difficult due to the similarity of clinical features across disorders and their variability. Clinical features can include bone abnormalities, coarse facial features, corneal cloudiness, organomegaly, muscle weakness, hypotonia, developmental delay, and ataxia. Age of onset ranges from early infancy to adult and can even present prenatally. This is the recommended test for the initial workup of a suspected oligosaccharidosis disorder.. The oligosaccharidosis in this subset of lysosomal storage disorders and detected by this assay are alpha-mannosidosis, beta-mannosidosis, ...
The catalytic performances of different commercial cobalt oxides(CoxOy, i.e., Co2O3, Co3O4, and CoO) for peroxymonosulfate(PMS) activation in dye degradation were compared in this study. The CoO/PMS system exhibited the highest catalytic oxidation performances with more than 96% methylene blue(MB) removal at 90 min. The concentration of dissolved cobalt ions from CoO was 1.474 mg/L at neutral pH and 5.231 mg/L at acidic pH at 90 min which accounted for the high MB removal and CoO activated PMS homogeneously compared to the associated CoSO4/PMS. Co3O4 and Co2O3 exhibited similar catalytic performances and characteristics. The MB removal in Co3O4/PMS and Co2O3/PMS system were more than 88% at neutral pH and over 64% at acidic pH, respectively, in 90 min. The concentration of dissolved cobalt ions from Co3O4 and Co2O3 was less than 0.018 mg/L at neutral pH and 0.036 mg/L at acidic pH at 90 min. The MB removal achieved by Co3O4/PMS and Co2O3/PMS were approximately three times higher than that ...
Satu-satunya makanan kegemaran aku,..selalu saja menjadi santapan jika kelapangan...rasanya semua orang tahu jika disebut laksa...Kat negeri Kedah ni,..laksa biasanya dibuat berkuah asam dan lemak...aku paling suka yang laksa asam..percaya atau tidak,..laksa asam orang kedah walaupun pakai resepi yang sama tapi akan berbeza rasanya...ini mengikut pengalaman hidup disini dan dari penelitian serta kajian sendiri..he he..tak percaya?...cuba sendiri..laksa ct berbeza dgn laksa orang lain...walau resepinya sama.... Resepi...laksa ct.... 2 kg ikan selayang (sardin) atau ikan kembung..mesti yang baru naik dari bot nelayan..dibersihkan, rebus dan asingkan isinya. kisar tulang dan ambil airnya... 100 gram cili kering + 300 gram bawang besar + 2 jari belacan - dikisar lumat.. 2 bungkus laksa. Cara ct masak. Cili dan bawang serta belacan yang dikisar dipanaskan bersama air rebusan tulang ikan sampai masak cili tadi...masukkan air sebanyak 3 liter beserta isi ikan yang dikisar halus...tambah daun kesum, ...
As energy saving regulations are gradually tightened and products continue to be miniaturized, demand is increasing for microcontrollers (MCUs) with low pin-count that can efficiently control multiple motors. The new products meet requirements for the motor control systems of home appliances, such as air-conditioners, and are based on the ARM® Cortex®-M4F, which incorporates a floating point processing unit. Integrated features include a high-precision AD convertor with a 0.5 μs conversion speed, high-speed Flash memory with 80 MHz operation, and a co-processor for Toshibas original vector engine. Together, they ensure the new products realize efficient motor control while improving the power factor and system control.. ...
Creative Biomart offer edem3 proteins for life sciences research. All the products are rigorously tested to meet the most demanding research needs. At the same time, lowest prices in the industry are always guaranteed.
In a new study, to be published in Nature Neuroscience, Helene Plun-Favreau and Alex Whitworth from the Neurodegeneration consortium, along with Heike Laman from Cambridge University, have established a role for Fbxo7, a gene associated with familial Parkinsons disease (PD). Helene talks about the results from the paper below: Mitochondria are the
Toshiba has begun shipping a 14TB helium-filled hard drive to clients, its largest capacity to date and the company's first foray into helium territory. Of course, helium-filled HDDs are not new, and WD already released a 14TB HDD a couple of months ago. However, Toshiba's is the industry's first HDD to pack nine disks inside, and the only 14TB drive to use conventional magnetic recording (CMR) technology.The new drive is part of Toshiba's MG07ACA series. It is available in both 12TB and 14TB capacities, both of which are CMR drives.We have raised the bar with the new MG07ACA Series 9-disk helium-sealed design, said Akitoshi Iwata, Vice President of Storage Products Division, Toshiba Electronic Devices and Storage Corporation. By utilizing an innovative design, we continue to improve the benefits that high-capacity disk storage can deliver to our broad global customer base.There are a couple of things to note about the 14TB model that make it sta
Human EDEM2 full-length ORF ( AAH01371.1, 1 a.a. - 578 a.a.) recombinant protein with GST-tag at N-terminal. (H00055741-P01) - Products - Abnova
食品、饮料与营养保健品 (Glycosidase) | 食品、饮料与营养保健品 一站式进行配方,数据表,物质安全数据表搜索,产品特性和样品申请 -- 免费使用
Background: Some salivary markers of alcohol abuse/dependence have been proposed so far: aminotransferases, gamma-glutamyltransferase, ethanol, ethyl glucuronide, ethyl sulfate, sialic acid, β-hexosaminidase A, oral peroxidase, methanol, diethylene/ethylene glycol, α-amylase, clusterin, haptoglobin, heavy/light chains of immunoglobulins and transferrin. Aim: To investigate the effect of chronic alcohol drinking and smoking on the activity (pKat/ml) and output (pKat/min) of salivary lysosomal exoglycosidases: α-fucosidase (FUC), α-mannosidase (MAN), β-galactosidase (GAL), and β-glucuronidase (GLU), and their applicability as markers of alcohol dependence. Methods: The activity of FUC, MAN, GAL and GLU was measured colorimetrically in the saliva of healthy social drinkers, alcohol-dependent non-smokers and alcohol-dependent smokers. Results: We observed an increased salivary activity of FUC, GAL, GLU and MAN, as well as an increased output of GAL and GLU, in comparison with controls. The ...
Misfolded proteins are recognized in the endoplasmic reticulum (ER), transported back to the cytoplasm and degraded by the proteasome. Processing intermediates of N-linked oligosaccharides on incompletely folded glycoproteins have an important role in their folding/refolding, and also in their targeting to proteolytic degradation. In Saccharomyces cerevisiae, we have identified a gene coding for a non-essential protein that is homologous to mannosidase I (HTM1) and that is required for degradation of glycoproteins. Deletion of the HTM1 gene does not affect oligosaccharide trimming. However, deletion of HTM1 does reduce the rate of degradation of the mutant glycoproteins such as carboxypeptidase Y, ABC-transporter Pdr5-26p and oligosaccharyltransferase subunit Stt3-7p, but not of mutant Sec61-2p, a non-glycoprotein. Our results indicate that although Htm1p is not involved in processing of N-linked oligosaccharides, it is required for their proteolytic degradation. We propose that this mannosidase ...
The cell-wall D-mannans of Candida parapsilosis, Endomycopsis fibuliger, Saccharomyces rouxii, Torulopsis apicola (Hajsig strain), and Torulopsis bombi were degraded with an exo alpha-D-mannosidase from Arthrobacter GJM-1 to their alpha-(1-6)-linked D-mannopyranose main-chains, as demonstrated by p.m.r. spectroscopy. D-Galacto-D-mannans from Candida lipolytica, Torulopsis gropengiesseri, Torulopsis lactis-condensi, Torulopsis magnoliae, and Trichosporon fermentans could be degraded to polysaccharides containing mainly 6-O-linked alpha-D-mannopyranosyl residues following preferential removal of their enzyme-resistant, D-galactopyranosyl non-reducing end-units with acid. The D-mannans of Saccharomyces lodderi, Citeromyces matritensis, and Pichia pastoris could also be enzymically degraded to polysaccharides containing predominantly alpha-(1-6)-linked D-mannopyranosyl residues after hydrolysis of most of the beta-D-linked residues in their side chains with acid. The exo alpha-D-mannosidase, as would be
Sugar moieties on the cell surface play one of the most important roles in cellular recognition. In order to elucidate the molecular mechanism of these cellular phenomena, assessment of the structure...
glycosidase Definition, glycosidase Best Plays of glycosidase in Scrabble® and Words With Friends, Length tables of words in glycosidase, Word growth of glycosidase, Sequences of glycosidase
NICE BLOG....pakjoe nk bg tau nie pakjoe ada byk lg tip blog yg nk bg kt tuan blog jemput siggah ke laman bl0g pakjoe jgn lpa tau sbb pakjoe dh follow ...
Edem3 - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN304999G1|/strong|, Edem3 gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
Alibaba.com offers 40,542 silicone storage products. About 52% of these are storage boxes & bins, 2% are storage baskets, and 1% are storage holders & racks. A wide variety of silicone storage options are available to you, such as food, tableware.
3.2.1.1 Alpha-amylase 3.2.1.2 Beta-amylase 3.2.1.3 Glucan 1,4-alpha-glucosidase 3.2.1.4 Cellulase 3.2.1.5 Deleted entry 3.2.1.6 Endo-1,3(4)-beta-glucanase 3.2.1.7 Inulinase 3.2.1.8 Endo-1,4-beta-xylanase 3.2.1.9 Deleted entry 3.2.1.10 Oligo-1,6-glucosidase 3.2.1.11 Dextranase 3.2.1.12 Transferred entry: 3.2.1.54 3.2.1.13 Transferred entry: 3.2.1.54 3.2.1.14 Chitinase 3.2.1.15 Polygalacturonase 3.2.1.16 Deleted entry 3.2.1.17 Lysozyme 3.2.1.18 Exo-alpha-sialidase 3.2.1.19 Deleted entry 3.2.1.20 Alpha-glucosidase 3.2.1.21 Beta-glucosidase 3.2.1.22 Alpha-galactosidase 3.2.1.23 Beta-galactosidase 3.2.1.24 Alpha-mannosidase 3.2.1.25 Beta-mannosidase 3.2.1.26 Beta-fructofuranosidase 3.2.1.27 Deleted entry 3.2.1.28 Alpha,alpha-trehalase 3.2.1.29 Transferred entry: 3.2.1.52 3.2.1.30 Transferred entry: 3.2.1.52 3.2.1.31 Beta-glucuronidase 3.2.1.32 Endo-1,3-beta-xylanase 3.2.1.33 Amylo-alpha-1,6-glucosidase 3.2.1.34 Transferred entry: 3.2.1.35 3.2.1.35 Hyaluronoglucosaminidase 3.2.1.36 ...

Suppressive effects of swainsonine on C6 glioma cell in vitro and in vivo. - Free Online LibrarySuppressive effects of swainsonine on C6 glioma cell in vitro and in vivo. - Free Online Library

Swainsonine is a potent and specific inhibitor of lysosomal acid and cytosolic [alpha]-mannosidases, as well as Golgi [alpha]- ... Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells. EM BO J. 20, 3008 ... Swainsonine, a water-soluble indole alkaloid and alpha-mannosidase inhibitor which blocks Golgi oligosaccharide processing, ... 4-N-acetylgluco saminyltransferase III and Golgi alpha-mannosidase II. Biotechnol Bioeng 93, 851-861. Ferreiro, E., Oliveira, C ...
more infohttps://www.thefreelibrary.com/Suppressive+effects+of+swainsonine+on+C6+glioma+cell+in+vitro+and+in+...-a0221083856

Mannan endo-1,6-alpha-mannosidase - WikipediaMannan endo-1,6-alpha-mannosidase - Wikipedia

Mannan endo-1,6-alpha-mannosidase (EC 3.2.1.101, exo-1,6-beta-mannanase, endo-alpha-1-,6-D-mannanase, endo-1,6-beta-mannanase, ... mannan endo-1,6-beta-mannosidase, 1,6-alpha-D-mannan mannanohydrolase) is an enzyme with systematic name 6-alpha-D-mannan ... Mannan endo-1,6-alpha-mannosidase at the US National Library of Medicine Medical Subject Headings (MeSH) ... Random hydrolysis of (1-,6)-alpha-D-mannosidic linkages in unbranched (1-,6)-mannans. References[edit]. *^ Nakajima, T.; Maitra ...
more infohttps://en.wikipedia.org/wiki/Mannan_endo-1,6-alpha-mannosidase

Alpha-Mannosidase - WikipediaAlpha-Mannosidase - Wikipedia

... alpha-D-mannosidase, p-nitrophenyl-alpha-mannosidase, alpha-D-mannopyranosidase, 1,2-alpha-mannosidase, 1,2-alpha-D-mannosidase ... GeneReviews/NCBI/NIH/UW entry on Alpha-Mannosidosis OMIM entries on Alpha-Mannosidosis alpha-Mannosidase at the US National ... exo-alpha-mannosidase) is an enzyme involved in the cleavage of the alpha form of mannose. Its systematic name is alpha-D- ... Humans express the following three alpha-mannosidase isozymes: It can be utilized in experiments that determine the effects of ...
more infohttps://en.wikipedia.org/wiki/Alpha-Mannosidase

MAN2A1 - Alpha-mannosidase 2 - Homo sapiens (Human) - MAN2A1 gene & proteinMAN2A1 - Alpha-mannosidase 2 - Homo sapiens (Human) - MAN2A1 gene & protein

Alpha-mannosidase 2Add BLAST. 1144. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ... sp,Q16706,MA2A1_HUMAN Alpha-mannosidase 2 OS=Homo sapiens OX=9606 GN=MAN2A1 PE=1 SV=2 ... PF09261. Alpha-mann_mid. 1 hit. PF01074. Glyco_hydro_38. 1 hit. PF07748. Glyco_hydro_38C. 1 hit. ... PF09261. Alpha-mann_mid. 1 hit. PF01074. Glyco_hydro_38. 1 hit. PF07748. Glyco_hydro_38C. 1 hit. ...
more infohttp://www.uniprot.org/uniprot/Q16706

Golgi alpha-mannosidase II - WikipediaGolgi alpha-mannosidase II - Wikipedia

van den Elsen, J.M., Kuntz, D.A., Rose, D.R., "Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and ... Golgi α-mannosidase II is a key enzyme involved in N-linked Glycan processing. It is inhibited by small molecule swainsonine. ...
more infohttps://en.wikipedia.org/wiki/Golgi_alpha-mannosidase_II

alpha-mannosidase Inhibitors | SCBT - Santa Cruz Biotechnologyalpha-mannosidase Inhibitors | SCBT - Santa Cruz Biotechnology

View and select products within our alpha-mannosidase Inhibitors category available for immediate purchase. ... ChemCruz™ Chemical alpha-mannosidase Substrates for functional analysis of cellular responses to alpha-mannosidase ... Phenyl 2,3,4,6-Tetra-O-acetyl-1-thio-alpha-D-mannopyranoside A mannose analog that acts as an inhibitor of a-mannosidase 108032 ... alpha-mannosidase Inhibitors. Autophagy is a membrane trafficking mechanism that delivers cytoplasmic cargo to the vacuole/ ...
more infohttps://www.scbt.com/scbt/browse/alpha-mannosidase-inhibitors/_/N-13yhdos

EDEM1 - ER degradation-enhancing alpha-mannosidase-like protein 1 - Homo sapiens (Human) - EDEM1 gene & proteinEDEM1 - ER degradation-enhancing alpha-mannosidase-like protein 1 - Homo sapiens (Human) - EDEM1 gene & protein

It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. ... ER degradation-enhancing alpha-mannosidase-like protein 1Add BLAST. 657. Amino acid modifications. Feature key. Position(s). ... Cluster: ER degradation-enhancing alpha-mannosidase-like protein 1. 34. Q92611-2. UPI0006C9768B. F7HSG0. UPI0003EE3259. G1QUA5 ... Cluster: ER degradation-enhancing alpha-mannosidase-like protein 1. 98. Q92611-2. UPI0006C9768B. F7HSG0. UPI0003EE3259. G1QUA5 ...
more infohttp://www.uniprot.org/uniprot/Q92611

Alpha-mannosidase-II deficiency results in dyserythr - baddlyllibrary73 siteAlpha-mannosidase-II deficiency results in dyserythr - baddlyllibrary73 site

HomeAlpha-mannosidase-II deficiency results in dyserythr. Alpha-mannosidase-II deficiency results in dyserythr. By admin ...
more infohttp://baddlyllibrary73.site/alpha-mannosidase-ii-deficiency-results-in-dyserythr/

Characterization of alpha-mannosidase from Erythrina indica seeds and influence of endogenous lectin on its activity.  - PubMed...Characterization of alpha-mannosidase from Erythrina indica seeds and influence of endogenous lectin on its activity. - PubMed...

alpha-Mannosidase from E indica exhibits immunological identity with alpha-mannosidase from Canavalia ensiformis but not with ... alpha-mannosidase from Erythrina indica seeds is a Zn(2+) dependent glycoprotein with 8.6% carbohydrate. The enzyme has a ... Characterization of alpha-mannosidase from Erythrina indica seeds and influence of endogenous lectin on its activity.. Kestwal ... Incubation of E. indica seed lectin with alpha-mannosidase resulted in 35% increase in its activity, while no such activation ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16935428

Aryl-alpha-mannosidase: Definition with Aryl-alpha-mannosidase Pictures and PhotosAryl-alpha-mannosidase: Definition with Aryl-alpha-mannosidase Pictures and Photos

Definition of Aryl-alpha-mannosidase with photos and pictures, translations, sample usage, and additional links for more ... Act on p-nitrophenyl-alpha-d-mannopyranoside Registry number: EC 3.2.1.- Synonym: aryl-alpha-mannosidase a, aryl-alpha- ... Aryl-alpha-mannosidase Images Lexicographical Neighbors of Aryl-alpha-mannosidase. arvels. arvicole. arvicoles. arviculture. ... Aryl-alpha-mannosidase Pictures. Click the following link to bring up a new window with an automated collection of images ...
more infohttp://www.lexic.us/definition-of/aryl-alpha-mannosidase

Alpha-mannosidase from the seeds of Triticale. - Semantic ScholarAlpha-mannosidase from the seeds of Triticale. - Semantic Scholar

38, 1059-1066). Seed extracts also exhibited alpha-mannosidase activity that was isolated by a combination of ion exchange, ... Both subunits cross-reacted with an antibody to the well-characterized jack bean alpha-mannosidase, suggesting antigenic ... similarity between the legume and the cereal mannosidases. Purified enzyme binds to Con A-Sepharose gel, possibly through the ... Alpha-mannosidase from the seeds of Triticale.. *. A Subha Mahadevi, R Vegiraju Suryanarayana, Nadimpalli Siva Kumar ...
more infohttps://www.semanticscholar.org/paper/Alpha-mannosidase-from-the-seeds-of-Triticale.-Mahadevi-Suryanarayana/4bd8ca5fc2f3f11312fc342f865d92a18ce7125a

Alpha-mannosidase 2C1Alpha-mannosidase 2C1

Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free ...
more infohttps://pharos.nih.gov/idg/targets/Q9NTJ4

Alpha-mannosidase 2xAlpha-mannosidase 2x

Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase ... Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl ... Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl ... Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl ...
more infohttps://pharos.nih.gov/idg/targets/P49641

Alpha-MannosidaseAlpha-Mannosidase

... Inhibition of match element 5 (C5) reduced myocardial infarction in pet November 22, 2018, admin Alpha- ... August 14, 2018, admin Alpha-Mannosidase, In developed countries, like the UK and america, between 15% and 20% of the populace ... January 9, 2018, admin Alpha-Mannosidase, Hepatitis C Pathogen (HCV) is a serious global wellness issue, infecting almost 3% of ... October 14, 2017, admin Alpha-Mannosidase, analysis of biomarkers is highly desirable in molecular pathology since it allows ...
more infohttp://www.atlantabiotechnetwork.net/category/alpha-mannosidase/

Alpha-mannosidosis : Alpha-mannosidase Enzyme AnalysisAlpha-mannosidosis : Alpha-mannosidase Enzyme Analysis

Demonstration of deficient alpha-mannosidase enzyme activity is considered the gold standard to confirm a diagnosis of alpha- ... Alpha mannosidosis is an autosomal recessive lysosomal storage disorder caused by a deficiency of alpha-mannosidase enzyme ... This biochemical test is a quantitative measurement of alpha-mannosidase enzyme activity and can be used as a 1st tier test for ... patients with a clinical suspicion of alpha-mannosidosis. ... Alpha-mannosidosis : Alpha-mannosidase Enzyme Analysis. PRINT ...
more infohttps://greenwoodgeneticcenter.isinproduction.com/test-finder-item/alpha-mannosidosis-alpha-mannosidase-enzyme-analysis

Alpha-MannosidaseAlpha-Mannosidase

california Alpha-Mannosidase Axitinib cell signaling, CCR1. is the cause of glanders and a proven biological weapon. disease of ... california Alpha-Mannosidase AZD8055 price, Efnb2. Within the occasion of the 20th anniversary of the Center for Alternative ... california Alpha-Mannosidase AZD0530 cost, Rabbit Polyclonal to GTPBP2. The gut microbiota is increasingly named a health asset ... california Alpha-Mannosidase PU-H71 inhibitor, Tshr. Data Availability StatementThe datasets used and/or analysed through the ...
more infohttp://www.californiaehealth.org/index.php/category/alpha-mannosidase/

Alpha-Mannosidase | The Role of mGluR Copy Number Variation in GeneticAlpha-Mannosidase | The Role of mGluR Copy Number Variation in Genetic

Category Archives: Alpha-Mannosidase. Epidemiological studies suggest that vitamin D protects against prostate cancer, although ...
more infohttp://mglur.info/category/alpha-mannosidase/

Alpha-MannosidosisAlpha-Mannosidosis

It is caused by mutations of the MAN2B1 gene, which lead to alpha-mannosidase deficiency. AM is associated with facial ... which may also be referred to as lysosomal acid hydrolase alpha-mannosidase or LAHAM. ... Alpha-mannosidosis (AM) is a lysosomal storage disease, ... which lead to alpha-mannosidase deficiency. Alpha-mannosidase ... Alpha-Mannosidosis. Deficiency of Alpha-Mannosidase. Alpha-mannosidosis (AM) is a lysosomal storage disease, which may also be ...
more infohttps://www.symptoma.com/en/info/alpha-mannosidosis

Author: Cui, Xikai / Subject: beta-galactosidase and alpha-mannosidase - PubAg Search ResultsAuthor: 'Cui, Xikai' / Subject: beta-galactosidase and alpha-mannosidase - PubAg Search Results

... alpha-mannosidase Remove constraint Subject: alpha-mannosidase Start Over ... Escherichia coli; Orthomyxoviridae; Streptococcus pneumoniae; acetaminophen; alpha-mannosidase; bacteria; beta-galactosidase; ... This approach was used to detect a number of diverse analytes that include enzymes such as β-galactosidase and α-mannosidase ...
more infohttps://pubag.nal.usda.gov/?f%5Bsubject_term%5D%5B%5D=beta-galactosidase&f%5Bsubject_term%5D%5B%5D=alpha-mannosidase&q=%22Cui%2C+Xikai%22&search_field=author

mans-1 alpha-1,2-Mannosidase [Caenorhabditis elegans] - Gene - NCBImans-1 alpha-1,2-Mannosidase [Caenorhabditis elegans] - Gene - NCBI

alpha-1,2-Mannosidase. Primary source. WormBase:WBGene00008411 Locus tag. CELE_D2030.1 Gene type. protein coding. RNA name ... alpha-1,2-Mannosidase. RefSeq status. REVIEWED. Organism. Caenorhabditis elegans (strain: Bristol N2) Lineage. Eukaryota; ... mans-1 alpha-1,2-Mannosidase [ Caenorhabditis elegans ] Gene ID: 172510, updated on 12-Aug-2018 ... mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA Inferred from Biological aspect of Ancestor. more info ...
more infohttps://www.ncbi.nlm.nih.gov/gene/172510

Anti-alpha 1,2 Mannosidase IA antibody (ab51262) | AbcamAnti-alpha 1,2 Mannosidase IA antibody (ab51262) | Abcam

2 Mannosidase IA antibody. Validated in WB, ICC/IF and tested in Mouse, Rat, Human. Cited in 1 publication(s). Independently ... Anti-alpha 1,2 Mannosidase IA antibody. See all alpha 1,2 Mannosidase IA primary antibodies. ... Anti-alpha 1,2 Mannosidase IA antibody (ab51262) at 1/1000 dilution + Human colon whole cell lysate at 40 µg. Secondary. HRP- ... Western blot - Anti-alpha 1,2 Mannosidase IA antibody (ab51262)This image is courtesy of an Abreview submitted by Praveen ...
more infohttps://www.abcam.com/alpha-12-mannosidase-ia-antibody-ab51262.html

Refubium - Analyse der Bedeutung der alpha-Mannosidase I und RHAMM für die
T-ZellaktivierungRefubium - Analyse der Bedeutung der alpha-Mannosidase I und RHAMM für die T-Zellaktivierung

alpha-Mannosidase I Die alpha-Mannosidase I ist ein Schlüsselenzym bei der Biosynthese von N-Glycanen und wurde in Transplantat ... Alpha-mannosidase I function was altered by i) treatment with Kifunensine, a specific inhibitor for class I alpha-mannosidases ... Analyse der Bedeutung der alpha-Mannosidase I und RHAMM für die T-Zellaktivierung. Haupttitel: Analyse der Bedeutung der alpha- ... I now studied the expression and function of alpha-mannosidase I in total CD4+, naïve and memory T cells by analysing alpha- ...
more infohttps://refubium.fu-berlin.de/handle/fub188/7909

Buy EDEM3-ER degradation enhancer, mannosidase alpha-like 3 GeneBuy EDEM3-ER degradation enhancer, mannosidase alpha-like 3 Gene

... mannosidase alpha-like 3 Gene from ProteoGenix cat# PTXBC016464. Shop among our wide range of DNA & cDNAavailable at highly ... mannosidase alpha-like 3. Synonyms: alpha-1,2-mannosidase EDEM3; C1orf22; ER degradation-enhancing alpha-mannosidase-like ... mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like 3; ER degradation enhancing alpha-mannosidase like ... More info about EDEM3-ER degradation enhancer, mannosidase alpha-like 3 Gene. Proteogenix catalog: PTXBC016464. ...
more infohttps://www.proteogenix-products.com/8270-edem3-er-degradation-enhancer-mannosidase-alpha-like-3-gene.html

RCSB PDB 









- 1KRF: STRUCTURE OF P. CITRINUM ALPHA 1,2-MANNOSIDASE REVEALS THE BASIS FOR DIFFERENCES IN SPECIFICITY OF...RCSB PDB - 1KRF: STRUCTURE OF P. CITRINUM ALPHA 1,2-MANNOSIDASE REVEALS THE BASIS FOR DIFFERENCES IN SPECIFICITY OF...

2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes. ... All alpha proteins alpha/alpha toroid Seven-hairpin glycosidases Class I alpha-1;2-mannosidase, catalytic domain Class I alpha- ... All alpha proteins alpha/alpha toroid Seven-hairpin glycosidases Class I alpha-1;2-mannosidase, catalytic domain Class I alpha- ... Mannosyl-oligosaccharide alpha-1,2-mannosidase (1KRF:A,B) * Mannosyl Oligosaccharide 1 2 Alpha Mannosidase Activity ...
more infohttp://www.rcsb.org/pdb/explore/derivedData.do?structureId=1KRF

SWISS-MODEL Template Library | 3ddg.1SWISS-MODEL Template Library | 3ddg.1

GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) methylpyrrolidin-2- ... Fiaux, H. et al., Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing ... GOLGI MANNOSIDASE II complex with (3R,4R,5R)-3,4-Dihydroxy-5-({[(1R)-2-hydroxy-1 phenylethyl]amino}methyl) methylpyrrolidin-2- ...
more infohttps://swissmodel.expasy.org/templates/3ddg.1
  • Incubation of E. indica seed lectin with alpha-mannosidase resulted in 35% increase in its activity, while no such activation was observed for acid phosphatase from E. indica. (nih.gov)
  • Alpha-mannosidosis (AM) is a lysosomal storage disease , which may also be referred to as lysosomal acid hydrolase alpha-mannosidase or LAHAM. (symptoma.com)
  • Click on the product name to view detailed information such as the chemical structure and specific chemical properties for each of our alpha-mannosidase Inhibitors. (scbt.com)
  • Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. (expasy.org)
  • Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). (abcam.com)
  • They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose. (genecards.org)
  • Humans express the following three alpha-mannosidase isozymes: It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development. (wikipedia.org)
  • Far-UV CD spectrum indicated predominance of alpha-helical structure in the enzyme. (nih.gov)
  • Lectin induced activation of alpha-mannosidase could be completely abolished in presence of lactose, a sugar specific for lectin. (nih.gov)
  • The six-hairpin glycoside transferase domain, with an alpha/alpha toroid fold, contains six alpha-hairpins arranged in closed circular array. (ebi.ac.uk)