OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
MacroglobulinsSerum GlobulinsFusobacteriaPregnancy-Associated alpha 2-Macroglobulinsalpha-MacroglobulinsWaldenstrom MacroglobulinemiaNeuraminic Acidsgamma-GlobulinsImmunoelectrophoresisImmunoglobulin M
Macroglobulins
Serum globulins with high molecular weight. (Dorland, 28th ed)
Serum Globulins
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
Fusobacteria
A phylum of anaerobic, gram-negative bacteria with a chemoorganotrophic heterotrophic metabolism. They are resident flora of the OROPHARYNX.
Pregnancy-Associated alpha 2-Macroglobulins
Large (>160 kDa) glycoproteins with electrophoretic mobility of ALPHA-GLOBULINS, found in high concentration in the plasma of pregnant women but also in a number of species including mouse, rat, and others (ALPHA-MACROGLOBULINS). In humans, they are always present in the circulation and are nonspecific inhibitors of PROTEINASES, similar to COMPLEMENT PROTEINS (C3; C4; C5).
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Waldenstrom Macroglobulinemia
A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.
Neuraminic Acids
gamma-Globulins
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Immunoglobulin M
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Structural details of proteinase entrapment by human alpha2-macroglobulin emerge from three-dimensional reconstructions of Fab labeled native, half-transformed, and transformed molecules. (1/1037)

Three-dimensional electron microscopy reconstructions of native, half-transformed, and transformed alpha2-macroglobulins (alpha2Ms) labeled with a monoclonal Fab Fab offer new insight into the mechanism of its proteinase entrapment. Each alpha2M binds four Fabs, two at either end of its dimeric protomers approximately 145 A apart. In the native structure, the epitopes are near the base of its two chisel-like features, laterally separated by 120 A, whereas in the methylamine-transformed alpha2M, the epitopes are at the base of its four arms, laterally separated by 160 A. Upon thiol ester cleavage, the chisels on the native alpha2M appear to split with a separation and rotation to give the four arm-like extensions on transformed alpha2M. Thus, the receptor binding domains previously enclosed within the chisels are exposed. The labeled structures further indicate that the two protomeric strands that constitute the native and transformed molecules are related and reside one on each side of the major axes of these structures. The half-transformed structure shows that the two Fabs at one end of the molecule have an arrangement similar to those on the native alpha2M, whereas on its transformed end, they have rotated. The rotation is associated with a partial untwisting of the strands and an enlargement of the openings to the cavity. We propose that the enlarged openings permit the entrance of the proteinase. Then cleavage of the remaining bait domains by a second proteinase occurs with its entrance into the cavity. This is followed by a retwisting of the strands to encapsulate the proteinases and expose the receptor binding domains associated with the transformed alpha2M.  (+info)

Heme and acute inflammation role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats. (2/1037)

Acute-phase protein synthesis in the liver during inflammation is regulated via cytokines and glucocorticoids. Using quantitative reverse transcription (RT)-PCR analysis and immunoassay, we explored, in the rat, the response of the acute-phase protein, alpha-2 macroglobulin (A2M), after systemic inflammation induced by lipopolysaccharide (LPS) or localized inflammation induced by turpentine oil (TO). The results indicate that synthesis of A2M is higher following TO-induced inflammation than LPS-induced inflammation and is not correlated with interleukin (IL)-6 or glucocorticoid levels. We studied the putative role of heme in this differential A2M expression following localized vs. systemic inflammation; addition of heme during LPS-induced inflammation can boost the expression of A2M, whereas blocking heme synthesis (by succinyl acetone) or enhancing its consumption in parallel biosynthetic pathways (cytochrome P450 induction by phenobarbital) decreases A2M expression. This decrease was abolished by exogenous heme supplementation. Finally, we demonstrate that heme supplementation is also able to increase the A2M response in female rats to a level similar to that in male rats providing a new insight into the puzzling sexual dimorphism observed previously during localized inflammation. We propose that heme should be considered a new regulatory element in controlling liver A2M expression during inflammation.  (+info)

Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity. (3/1037)

Legumain was recently discovered as a lysosomal endopeptidase in mammals [Chen, Dando, Rawlings, Brown, Young, Stevens, Hewitt, Watts and Barrett (1997) J. Biol. Chem. 272, 8090-8098], having been known previously only from plants and invertebrates. It has been shown to play a key role in processing of the C fragment of tetanus toxin for presentation by the MHC class-II system [Manoury, Hewitt, Morrice, Dando, Barrett and Watts (1998) Nature (London) 396, 695-699]. We examine here the specificity of the enzyme from pig kidney by use of protein, oligopeptide and synthetic arylamide substrates, all determinations being made at pH 5.8. In proteins, only about one in ten of the asparaginyl bonds were hydrolysed, and these were mostly predicted to be located at turns on the protein surface. Bonds that were not cleaved in tetanus toxin were cleaved when presented in oligopeptides, sometimes faster than an equivalent oligopeptide based on a bond that was cleaved in the protein. Legumain cleaved the bait region of rat alpha1-macroglobulin and was 'trapped' by the macroglobulin, as most other endopeptidases are, but did not interact with human alpha2-macroglobulin, which contains no asparagine residue in its bait region. Glycosylation of asparagine totally prevented hydrolysis by legumain. Specificity for arylamide substrates was evaluated with reference to benzyloxycarbonyl-Ala-Ala-Asn-aminomethylcoumarin, and the preference for the P3-position amino acid was Ala>Tyr(tertiary butyl)>Val>Pro>Phe=Tyr>Leu=Gly. There was no hydrolysis of substrate analogues containing mono- or di-N-methylasparagines, l-2-amino-3-ureidopropionic acid or citrulline in the P1 position. We conclude that mammalian legumain appears to be totally restricted to the hydrolysis of asparaginyl bonds in substrates of all kinds. There seem to be no strong preferences for particular amino acids in other subsites, and yet there are still unidentified factors that prevent hydrolysis of many asparaginyl bonds in proteins.  (+info)

Alpha2-macroglobulin and eosinophil cationic protein in the allergic airway mucosa in seasonal allergic rhinitis. (4/1037)

As previously demonstrated in seasonal allergic rhinitis, increased microvascular permeability and eosinophil activation are key features of allergic airway inflammation. In the present study, the hypothesis that exudation of alpha2-macroglobulin may cause the appearance of eosinophil cationic protein (ECP) in the airway lumen was explored. Nasal lavages were carried out using the nasal pool device before and during the pollen season both at baseline and after histamine challenge in 10 children with allergic rhinitis. Nasal lavage fluid levels of alpha2-macroglobulin and ECP were determined. All patients experienced nasal symptoms of allergic rhinitis during the pollen season (p<0.01-0.05). Baseline nasal lavage fluid levels of alpha2-macroglobulin and ECP were increased during the season (p<0.01-0.05) and were found to be well correlated (p<0.0001). Histamine produced concentration-dependent plasma exudation before and during the pollen season, but it was only during the pollen season that this caused an increase in the lavage fluid levels of ECP (p<0.05). These data suggest that exudation of plasma and increased tissue levels and output of eosinophil cationic protein characterize nasal mucosal inflammation in children with seasonal allergic rhinitis. The plasma exudation process in part may account for lumenal entry of eosinophil cationic protein molecules that have been released in mucosal tissue compartments. A combination of induced exudation and nasal lavage may improve the yield of important markers of inflammation in studies of nasal diseases.  (+info)

NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein. (5/1037)

The low density lipoprotein receptor-related protein is a member of the low density lipoprotein receptor family and contains clusters of cysteine-rich complement-like repeats of about 42 residues that are present in all members of this family of receptors. These clusters are thought to be the principal binding sites for protein ligands. We have expressed one complement-like repeat, CR8, from the cluster in lipoprotein receptor-related protein that binds certain proteinase inhibitor-proteinase complexes and used three-dimensional NMR on the 13C/15N-labeled protein to determine the structure in solution of the calcium-bound form. The structure is very similar in overall fold to repeat 5 from the low density lipoprotein receptor (LB5), with backbone root mean square deviation of 1.5 A. The calcium-binding site also appears to be homologous, with four carboxyl and two backbone carbonyl ligands. However, differences in primary structure are such that equivalent surfaces that might represent the binding interfaces are very different from one another, indicating that different domains will have very different ligand specificities.  (+info)

Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance. (6/1037)

OBJECTIVE: To examine whether subjects with impaired glucose tolerance (IGT) for more than 2 years have any abnormality in the kidney. RESEARCH DESIGN AND METHODS: We measured urinary excretion rate and clearance of various plasma proteins with different molecular radii and different isoelectric points in 22 Japanese men with IGT (IGT group) and 37 age-matched healthy control subjects (control group). RESULTS: Clearance of ceruloplasmin (molecular radius approximately 45 A; isoelectric point 4.4), IgG4 (molecular radius 55 A; isoelectric point 5.4), and IgG (molecular radius 55 A; isoelectric point 7.4) was significantly higher in the IGT group than in the control group, whereas there were no significant differences in urinary excretion rate of albumin (molecular radius 36 A; isoelectric points 4.8-5.2) and clearance of alpha 2-macroglobulin (molecular radius 88 A; isoelectric point 5.4) between the two groups. CONCLUSIONS: In the present study, we found that clearance of neutral-charged IgG, negatively charged IgG4, and ceruloplasmin with molecular radii of approximately 45-55 A was selectively increased in IGT subjects. This finding does not seem to be explained by impairment of charge and pore-size selectivity in the glomerulus. Therefore, considering the present result together with our recent finding that enhanced glomerular filtration rate (GFR) after acute protein loading in healthy subjects induced a selective increase in clearance of IgG, IgG4, and ceruloplasmin, we suggest that increased intraglomerular hydraulic pressure, although enhanced GFR was not demonstrated, may be at work in these mildly hyperglycemic subjects.  (+info)

Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin. (7/1037)

In the molecular interplay between pathogenic microorganisms and their host, proteolytic mechanisms are believed to play a crucial role. Here we find that the important human pathogen Streptococcus pyogenes (group A Streptococcus) expresses a surface protein with high affinity (Ka = 2.0 x 10(8) M-1) for alpha2-macroglobulin (alpha2M), the dominating proteinase inhibitor of human plasma. The immunoglobulin-binding protein G of group C and G streptococci also contains an alpha2M-binding domain and a gene encoding protein GRAB (protein G-related alpha2M-binding protein) was identified in the S. pyogenes Genome Sequencing data base. The grab gene is present in most S. pyogenes strains and is well conserved. Protein GRAB has typical features of a surface-attached protein of Gram-positive bacteria. It also contains a region homologous to parts of the alpha2M-binding domain of protein G and a variable number of a unique 28-amino acid-long repeat. Using Escherichia coli-produced protein GRAB and synthetic GRAB peptides, the alpha2M-binding region was mapped to the NH2-terminal part of protein GRAB, which is the region with homology to protein G. An isogenic S. pyogenes mutant lacking surface-associated protein GRAB showed no alpha2M binding activity and was attenuated in virulence when injected intraperitoneally in mice. Finally, alpha2M bound to the bacterial surface via protein GRAB was found to entrap and inhibit the activity of both S. pyogenes and host proteinases, thereby protecting important virulence determinants from proteolytic degradation. This regulation of proteolytic activity at the bacterial surface should affect the host-microbe relation during S. pyogenes infections.  (+info)

Destruction of articular cartilage by alpha 2 macroglobulin elastase complexes: role in rheumatoid arthritis. (8/1037)

OBJECTIVE: Neutrophil elastase accounts for the ability of some fresh rheumatoid synovial fluids to degrade cartilage matrix in vitro. The aim of this study was to determine if enzyme activity could result from depletion of synovial fluid inhibitors or protection of the enzyme from inhibition. METHODS: The ability of synovial fluids to inhibit porcine pancreatic elastase was investigated together with chemical pretreatments capable of inactivating alpha 1 protease inhibitor (alpha 1PI) or preventing formation of alpha 2 macroglobulin (alpha 2M) elastase complexes. Subsequently, complexes of human neutrophil elastase with alpha 2M were prepared and applied to frozen sections of cartilage. Proteoglycan loss was quantified by alcian blue staining and scanning and integrating microdensitometry. Parallel studies were carried out using a low molecular weight chromogenic elastase substrate. The effects of alpha 1PI and SF on these systems were investigated. Finally, synovial fluids were subjected to gel filtration and the fractions assayed for elastase activity. High molecular weight fractions were pooled, concentrated, and tested for their ability to degrade cartilage sections. RESULTS: All synovial fluids reduced the activity of porcine pancreatic elastase, the inhibition mainly being attributable to alpha 1PI, whereas remaining activity resulted from complexes of elastase with alpha 2M. Complexes of human neutrophil elastase with alpha 2M were shown to cause proteoglycan degradation in frozen sections of human articular cartilage. Alpha 1PI prevented alpha 2M elastase complexes from degrading cartilage but not the chromogenic substrate. The data suggested that alpha 1PI does not inhibit elastase bound to alpha 2M but sterically hinders the complex. However, only one of five synovial fluids was able to completely block the actions of alpha 2M elastase complexes against cartilage. Gel filtration of rheumatoid synovial fluids showed elastase and cartilage degrading activity to be associated with fractions that contained alpha 2M, and not with fractions expected to contain free enzyme. CONCLUSIONS: The data suggest that synovial fluid alpha 2M elastase complexes can degrade cartilage matrix in rheumatoid arthritis.  (+info)

Ligand binding, conformational change and plasma elimination of human, mouse and rat α-macroglobulin proteinase inhibitors |...Ligand binding, conformational change and plasma elimination of human, mouse and rat α-macroglobulin proteinase inhibitors |...
Rat alpha 1-macroglobulin (alpha 1M), rat alpha 2-macroglobulin (alpha 2M) migrated as single bands on non-denaturing gels when purified by the methods described. All three proteins demonstrated increased mobility after reaction with trypsin. A single saturable pathway rapidly cleared complexes of trypsin and the alpha-macroglobulins of mouse, rat and human from the circulation of mice. None of the native alpha-macroglobulins competed for clearance with the trypsin complexes. [14C]Methylamine incorporation was 4.1, 3.9, 2.6 and 3.2 mol/mol of proteinase inhibitor for human alpha 2M, rat alpha 1M, rat alpha 2M and mouse alpha 2M, respectively. Only rat alpha 2M, the acute-phase alpha-macroglobulin studied, showed no evidence of conformational change when subjected to electrophoresis after reaction with methylamine. The clearance of rat alpha 2M-methylamine was comparable with that of the native molecule. The other alpha-macroglobulin-methylamine complexes cleared faster than the inhibitors that ...
http://www.biochemj.org/content/209/1/99
alpha-Macroglobulins | Profiles RNS
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters ...
https://profiles.uchicago.edu/profiles/display/10756
Pregnancy zone proteinPregnancy zone protein
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase ...
https://pharos.nih.gov/idg/targets/P20742
Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin...Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin...
The binding of 125I-labelled transforming growth factor-beta 1 (TGF-beta 1) to human alpha 2-macroglobulin (alpha 2M) was studied by native PAGE and autoradiography. TGF-beta 1 bound preferentially to alpha 2M-methylamine and minimally, if at all, to native alpha 2M. Preparations of alpha 2M-proteinase complex were generated by incubating a standard concentration of alpha 2M (0.4 microM) with different concentrations of trypsin, chymotrypsin or neutrophil elastase (0.04-2.0 microM). The 125I-TGF-beta 1-binding activity depended on the initial ratio of active proteinase to alpha 2M, or r value, used to form the alpha 2M-proteinase complex. With all three proteinases, r values of 2 or greater yielded preparations with unchanged or decreased TGF-beta 1-binding activity relative to native alpha 2M. By contrast, r values near 1 yielded preparations with significantly increased TGF-beta 1-binding activity. The results of [3H]thymidine-incorporation studies performed in mouse keratinocytes were ...
http://www.biochemj.org/content/281/2/569
Absence of an α2-Macroglobulin-Protease Complex in Cystic Fibrosis - Semantic ScholarAbsence of an α2-Macroglobulin-Protease Complex in Cystic Fibrosis - Semantic Scholar
Extract: The present study using immunologic methodology confirms previous observations from this laboratory of an absence of a protease component with arginine esterase activity in plasma of patients with cystic fibrosis. In this study, the pooled plasma from control individuals was activated and partially purified after adsorption on columns of soybean trypsin inhibitor conjugated to Sepharose 4B followed by elution with benzamidine. The fraction was further purified by isoelectrofocusing on polyacrylamide gels. Proteins around the pI range of 5.5 were eluted and utilized to prepare an antiserum. Immunoelectrophoresis of activated plasma samples from control subjects and patients with cystic fibrosis was performed utilizing the antiserum. In controls, four precipitin arcs with residual esterase activity were observed, whereas only three were seen in plasma from patients with cystic fibrosis. Double gel diffusion experiments using specific antisera ruled out the presence of trypsin, chymotrypsin,
https://www.semanticscholar.org/paper/Absence-of-an-%CE%B12-Macroglobulin-Protease-Complex-in-Shapira-Rao/3a9275bee961b615ac74bc151eaaba064c39059d
Alpha-2-macroglobulin-like protein 1Alpha-2-macroglobulin-like protein 1
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases ...
https://pharos.nih.gov/idg/targets/A8K2U0
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site | PNASPotent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site | PNAS
Twenty-five monoclonal antibodies were generated by immunizing mice. Of these, the one named R10 had the strongest neutralizing activity against HAV [a 50% neutralizing concentration (neut50) value of ∼2 nM, ∼0.3 μg/mL]. The Fab fragment is also strongly neutralizing (neut50 = ∼3 nM, ∼0.45 μg/mL) (Fig. 1A). R10 does not recognize linear epitopes by immunoblot, but recognizes conformational epitopes by ELISA, and shows similar binding affinities to full and empty particles (Fig. 1B). Interestingly, a fluorescent assay revealed that whereas the R10 Fab portion destabilizes full HAV particles by 7 °C, the intact R10 stabilizes the particles by 2 °C (Fig. 1C and Fig. S1A). The same assay indicates that the bivalent intact antibody induces a two-stage transition in protein conformation to release the RNA genome (Fig. 1C and Fig. S1A). The first event, producing a slight exposure of RNA, occurs at a similar temperature to that seen with the Fab, whereas the second, which fully exposes the ...
https://www.pnas.org/content/114/4/770?ijkey=839820e025e01a516c3a46afb9db4a802272b530&keytype2=tf_ipsecsha
Assay Solution. Human alpha 2-Macroglobulin ELISA KitAssay Solution. Human alpha 2-Macroglobulin ELISA Kit
Alpha-2-Macroglobulin (α2M) is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. In humans it is encoded by the A2M gene. Alpha 2 macroglobulin acts as an antiprotease and is able to inactivate an enormous variety of proteinases. It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein. It functions as an inhibitor of coagulation by inhibiting thrombin. Alpha-2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β. No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of alpha-2-macroglobulin. The concentration of alpha-2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are ...
https://assaysolution.com/human-alpha-2-macroglobulin-elisa-kit
SMART: A2M N 2 domain annotationSMART: A2M N 2 domain annotation
This is a domain of the alpha-2-macroglobulin family.. The alpha-macroglobulin (aM) family of proteins includes protease inhibitors [(PUBMED:2473064)], typified by the human tetrameric a2-macroglobulin (a2M); they belong to the MEROPS proteinase inhibitor family I39, clan IL. These protease inhibitors share several defining properties, which include (i) the ability to inhibit proteases from all catalytic classes, (ii) the presence of a bait region and a thiol ester, (iii) a similar protease inhibitory mechanism and (iv) the inactivation of the inhibitory capacity by reaction of the thiol ester with small primary amines. aM protease inhibitors inhibit by steric hindrance [(PUBMED:2472396)]. The mechanism involves protease cleavage of the bait region, a segment of the aM that is particularly susceptible to proteolytic cleavage, which initiates a conformational change such that the aM collapses about the protease. In the resulting aM-protease complex, the active site of the protease is sterically ...
http://smart.embl.de/smart/do_annotation.pl?DOMAIN=A2M_N_2&START=449&END=599&E_VALUE=2.55e-41&TYPE=SMART&BLAST=IYLDTETSSILPCNQIHTVQAHFILKGDLGVLKELIFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGKFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLRFSTSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLL
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...
The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes and compositions com
http://patents.com/us-9566348.html
anti-alpha 2 Macroglobulin antibody [N2N3] | GeneTexanti-alpha 2 Macroglobulin antibody [N2N3] | GeneTex
alpha 2 Macroglobulin antibody [N2N3] (alpha-2-macroglobulin) for WB. Anti-alpha 2 Macroglobulin pAb (GTX112856) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/alpha-2-Macroglobulin-antibody-N2N3-GTX112856.html
Fertility Pregnancy Calculator | The Pregnancy ZoneFertility Pregnancy Calculator | The Pregnancy Zone
Now you can calculate your Pregnancy Fertility by using the Fertility calculator and here are the steps to calculate fertility by using a calculator.
http://www.thepregnancyzone.com/fertility-calculator/
PREGNANCY ZONE - FertilityZonePREGNANCY ZONE - FertilityZone
Dear visitor, welcome to FertilityZone . If this is your first visit here, please read the Help. It explains in detail how this page works. To use all features of this page, you should consider registering. Please use the registration form, to register here or read more information about the registration process. If you are already registered, please login here.. ...
http://www.pregnancyzone.co.uk/index.php?page=Board&boardID=10&s=eec4586f72f94adff59eaad0a79fd7f546e47b48
PREGNANCY ZONE - FertilityZonePREGNANCY ZONE - FertilityZone
Dear visitor, welcome to FertilityZone . If this is your first visit here, please read the Help. It explains in detail how this page works. To use all features of this page, you should consider registering. Please use the registration form, to register here or read more information about the registration process. If you are already registered, please login here.. ...
http://www.pregnancyzone.co.uk/index.php?page=Board&boardID=10&s=cdb2709e58404f9e944e59d734f5857cc334b3da&styleID=11&s=6e3d6a5c45b8f1b5efe242eb6b6c9a58d1da2981
Effects of GMO Foods on Pregnant Woman | The Pregnancy ZoneEffects of GMO Foods on Pregnant Woman | The Pregnancy Zone
Pregnant women beware - if you eat genetically modified organism or the GMO foods, you may be exposing your unborn baby to dangerous toxins.
https://www.thepregnancyzone.com/prenatal-care/pregnancy-diet/gmo-foods-affect-your-pregnancy/
Segmentation Fault with development versions of R, Bioconductor, and DropletUtils when processing output of CellRanger 3.0.2Segmentation Fault with development versions of R, Bioconductor, and DropletUtils when processing output of CellRanger 3.0.2
tmp ,- /home/met/data/Hong_Lab/02Apr19/S11M , sce ,- read10xCounts(tmp) , mol.info ,- read10xMolInfo(/home/met/data/Hong_Lab/02Apr19/S11M/molecule_info.h5) , no.sampling ,- downsampleReads(/home/met/data/Hong_Lab/02Apr19/S11M/molecule_info.h5, prop=1) Error: segfault from C stack overflow , with.sampling ,- downsampleReads(/home/met/data/Hong_Lab/02Apr19/S11M/molecule_info.h5, prop=0.5) Error: segfault from C stack overflow , sessionInfo() R Under development (unstable) (2019-04-01 r76306) Platform: x86_64-pc-linux-gnu (64-bit) Running under: openSUSE Leap 15.0 Matrix products: default BLAS/LAPACK: /usr/local/lib/OpenBLAS_home/lib/libopenblas_zenp-r0.2.20.so locale: [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C [3] LC_TIME=en_US.UTF-8 LC_COLLATE=en_US.UTF-8 [5] LC_MONETARY=en_US.UTF-8 LC_MESSAGES=en_US.UTF-8 [7] LC_PAPER=en_US.UTF-8 LC_NAME=C [9] LC_ADDRESS=C LC_TELEPHONE=C [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C attached base packages: [1] parallel stats4 stats graphics grDevices ...
https://support.bioconductor.org/p/119831/
AID 4853 - Compound was tested for its ability to displace [125I]GTI binding to 5-hydroxytryptamine 1D receptor recognition...AID 4853 - Compound was tested for its ability to displace [125I]GTI binding to 5-hydroxytryptamine 1D receptor recognition...
BioAssay record AID 4853 submitted by ChEMBL: Compound was tested for its ability to displace [125I]GTI binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranes.
https://pubchem.ncbi.nlm.nih.gov/bioassay/4853
Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of...Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of...
Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin.
https://scholars.duke.edu/display/pub674193
Gentaur Molecular :Kamiya \ Rat Alpha 2 Macroglobulin ELISA \ KT-353Gentaur Molecular :Kamiya \ Rat Alpha 2 Macroglobulin ELISA \ KT-353
Gentaur molecular products has all kinds of products like :search , Kamiya \ Rat Alpha_2 Macroglobulin ELISA \ KT-353 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=391256&supplier=search&name=Rat%20Alpha_2%20Macroglobulin%20ELISA
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017 Download the full report: https://www.
http://www.medindia.net/health-press-release/Complement-C5-C3-And-PZP-Like-Alpha-2-Macroglobulin-Domain-Containing-Protein-4-or-C5-Pipeline-Review-H2-2017--344249-1.htm
Content - Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2018 |...Content - Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2018 |...
Content - SummaryComplement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) pipeline Target constitutes close to 33 molec
https://www.asdreports.com/market-research-content-469691/complement-c-c-pzp-like-alpha-macroglobulin-domain-containing-protein
Natural Human alpha 2 Macroglobulin protein (ab91104)Natural Human alpha 2 Macroglobulin protein (ab91104)
Buy our Natural Human alpha 2 Macroglobulin protein. Ab91104 is a full length protein produced in Nativesyntheticaly and has been validated in SDS-PAGE. Abcam…
http://www.abcam.com/natural-human-alpha-2-macroglobulin-protein-ab91104.html
WO2011133920A1 - Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use - Google...
Provided are compounds of Formula I: Formula I or a pharmaceutically acceptable salt thereof, wherein R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, Z 1 , Z 2 , Z 3 , Z 4 and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
https://patents.google.com/patent/WO2011133920A1/en
BRIC Kit | MBL Life Sience -ASIABRIC Kit | MBL Life Sience -ASIA
Please optimize the BrU concentraiton, pulse-time, or chase-time. BrU concentrations of more than 500 μM may affect cell growth and/or other biological processes ...
http://ruo.mbl.co.jp/bio/g/support/faq_BRICKit.html
Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila
keywords = {*Gene Expression Regulation, *Genes, *Genome, *Homeostasis, *Immunity, *Models, *Nobel Prize, *RNA Interference, *RNA Interference, *Virulence, 5 Untranslated Regions, Abdomen, Actins, Active, Acute-Phase Proteins, Acute-Phase Proteins, Acute-Phase Proteins, Acute-Phase Proteins, Acylation, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adaptor Proteins, Adenosine Triphosphatases, Adenosine Triphosphate, Adenosine Triphosphate, Adipocytes, Adipogenesis, Adipose Tissue, Adipose Tissue, Adipose Tissue, Adult Stem Cells, Aedes, Aedes, Aedes, Aedes, Aedes, Aedes, Age Factors, Age Factors, Age Factors, Age Factors, Agglutination, Agglutination, Aging, Aging, Alleles, Alleles, Allergy and Immunology, alpha-Macroglobulins, alpha-Macroglobulins, alpha2-macroglobulins, Alphavirus, Alphavirus Infections, Alternative infection models, Alternative Splicing, Amino Acid, Amino Acid, ...
http://ibmc-m3i.cnrs.fr/en/2978-hyd-ubiquitinates-the-nf-%CE%BAb-co-factor-akirin-to-activate-an-effective-immune-response-in-drosophila/
Mucosal vaccination against Foot & Mouth Disease using bacterial toxin by Sreerupa V ChallaMucosal vaccination against Foot & Mouth Disease using bacterial toxin by Sreerupa V Challa
Synthetic peptides derived from the G-H loop of the Foot-and Mouth Disease Virus (FMDV) capsid protein VP1 are relatively poor at recapitulating the native conformation present in the virus, and thus are often poor immunogens. We hypothesized that a candidate mucosal vaccine against FMDV could be developed using the non-toxic Pseudomonas aeruginosa exotoxin A (ntPE) and B subunit of E. coli heat labile enterotoxin (LTB) to deliver the G-H loop in its native conformation. PE, secreted by Pseudomonas aeruginosa is a mucosal adjuvant that binds to α2-macroglobulin receptor/Low density Lipoprotein receptor-related Protein (LRP1)/CD91 present on epithelial cells and APC plasma membranes to traverse the mucosal barrier. The LTB subunit, a 55KDa pentameric molecule is also a potent mucosal adjuvant and is responsible for binding to various eukaryotic cell receptors including GM1, glycosphingolipids, glycoprotein receptors, polyglycosilceramides and paraglobosides. ^ The chimeric protein ntPE-GH was
https://opencommons.uconn.edu/dissertations/AAI3329118/
US Patent Application for METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASE USING ALPHA(2)...US Patent Application for METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASE USING ALPHA(2)...
The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. The invention also relates to methods for treating and preventing cancer and infectious disease using such complexes comprising, isolated from the serum of a mammal. The invention also encompasses methods for production of alpha (2) macroglobulin complexes.
https://patents.justia.com/patent/20150118253
Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly |...Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly |...
Hep I stimulates association of LRP with the Gαi2 subunit, and association is blocked by RAP and by peptides corresponding to the COOH terminus of Gαi2. (A) BAE cells were grown to near confluence and serum deprived overnight. Cells were then treated with 1 μM hep I for 0, 5, 10, 15, or 30 min and lysed. Cell lysates were immunoprecipitated with monoclonal anti-LRP antibody (8G1), separated by SDS-PAGE, and immunoblotted with mouse anti-Gαi2 antibodies. A representative immunoblot for LRP-associated Gαi2 is shown. Bands were analyzed using One-Dscan software (Scanalytics), and the fold change in LRP-Gαi2 association as compared with untreated conditions was determined. Equal loading of sample protein was assessed by protein staining with Ponceau S. *, P , 0.05; **, P , 0.01 (n = 3-5). (B) BAE cells were grown as in A, treated for 10 min with either DMEM, 100 nM hep I, 78 nM TSP, or 100 nM modified hep I and assayed for LRP-Gαi2 association as described in A. A representative immunoblot ...
https://rupress.org/jcb/article/161/6/1179/33434/Low-density-lipoprotein-receptor-related-protein
Lung bacteria feign pregnancy to avoid detection - Life Sciences ScotlandLung bacteria feign pregnancy to avoid detection - Life Sciences Scotland
Disease-causing bacteria in the lung evade the bodys immune system by pretending the lungs are pregnant, according to University of Dundee research presented today at the European Respiratory Society Congress in Madrid.. A new study, funded by the British Lung Foundation and the Scottish Governments Chief Scientist Office, has revealed that people with two common lung diseases - COPD and bronchiectasis - produce Pregnancy Zone Protein (PZP) in their lungs when they have a chest infection.. For the full article, please see here:. https://www.dundee.ac.uk/news/2019/lung-bacteria-feign-pregnancy-to-avoid-detection.php. ...
https://www.lifesciencesscotland.com/news/lung-bacteria-feign-pregnancy-avoid-detection
Studies on cell wall-attached proteins of <i>Streptococcus pyogenes</i>Studies on cell wall-attached proteins of <i>Streptococcus pyogenes</i>
phdthesis{e0687830-50ba-47d3-97d5-1bd517693461, abstract = {Cell wall-attached proteins (CWPs) are important for the virulence of Gram-positive bacteria, but are also targets for the host immune system. CWPs have a conserved COOH-terminal region, responsible for cell wall-sorting. A pattern based on this conserved region was developed. The pattern identifies genes encoding CWPs, with high sensitivity and specificity, in whole genomes of Gram-positive bacteria. In genomes of five Gram-positive bacterial species, 19 previously unknown putative CWPs were identified.,br/,,br, ,br/,,br, Three novel CWPs were identified and characterised in <i>Streptococcus pyogenes</i>, an important Gram-positive human pathogen. One CWP, GRAB, binds the human proteinase inhibitor alpha<sub>2</sub>-macroglobulin to the <i>S. pyogenes</i> surface, thus protecting other CWPs from proteolysis. Moreover, two novel CWPs (SclA and SclB) with regions similar to collagen were studied. These ...
https://lup.lub.lu.se/search/publication/42046
ALZFORUM | NETWORKING FOR A CUREALZFORUM | NETWORKING FOR A CURE
Ulery PG, Beers J, Mikhailenko I, Tanzi RE, Rebeck GW, Hyman BT, Strickland DK. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimers disease ...
https://www.alzforum.org/papers/modulation-beta-amyloid-precursor-protein-processing-low-density-lipoprotein-receptor-related
Sequence DetailSequence Detail
pep:known chromosome:VEGA66:19:3584828:3686556:-1 gene:OTTMUSG00000042195 transcript:OTTMUST00000110769 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Lrp5 description:low density lipoprotein receptor-related protein 5 ...
http://www.informatics.jax.org/sequence/OTTMUSP00000061850
A Receptor Mimic Neutralizing Mechanism Against Hepatitis A Virus Infection Identified by IBP and STRUBI Scientists---...
Using cryo-electron microscopy, an international group of scientists have reported a potent HAV-specific neutralizing monoclonal antibody R10 that blocks receptor attachment and interferes viral uncoating. High resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. HAV is unique amongst picornaviruses in targeting the liver, and despite a successful vaccine continues to be a source of mortality. It has radically different properties from other picornaviruses, for instance it exists in an enveloped form and is unusually stable, both genetically and physically. In 2015, IBP scientists solved crystal structure of unenveloped HAV showing no trace of the canyon which encircles the 5-fold axes of enteroviruses and is often the site of receptor binding. However, the molecular basis where the cellular receptor TIM-1 might attach remains unknown. ...
http://english.ibp.cas.cn/rh/rp/201705/t20170505_176786.html
Gentaur Molecular :Accu \ Alpha 2 Macroglobulin, Goat anti Human, Rabbit, Bovine, Swine, Dog, Cat \ ACL20010APGentaur Molecular :Accu \ Alpha 2 Macroglobulin, Goat anti Human, Rabbit, Bovine, Swine, Dog, Cat \ ACL20010AP
Gentaur molecular products has all kinds of products like :search , Accu \ Alpha_2_Macroglobulin, Goat anti_Human, Rabbit, Bovine, Swine, Dog, Cat \ ACL20010AP for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=18301&supplier=search&name=Alpha_2_Macroglobulin,%20Goat%20anti_Human,%20Rabbit,%20Bovine,%20Swine,%20Dog,%20Cat
OpenWrt Project: Cisco ON-100 k9 v01/ v02OpenWrt Project: Cisco ON-100 k9 v01/ v02
V / __/ , , ,_, ,_,\__,_,_, \_/ \___,_,_, _ _ ____ _ , , , , , __ ) ___ ___ , ,_ , , , ,___, _ \ / _ \ / _ \, __, , ,_, ,___, ,_) , (_) , (_) , ,_ \___/ ,____/ \___/ \___/ \__, ** MARVELL BOARD: DB-88F6282A-BP LE U-Boot 1.1.4 (Feb 22 2011 - 14:06:09) Marvell version: 3.5.9 - Cisco Plasma U-Boot code: 00600000 -, 0067FFF0 BSS: -, 006D2340 Soc: 88F6282 A1CPU running @ 1600Mhz L2 running @ 533Mhz SysClock = 400Mhz , TClock = 200Mhz DRAM (DDR3) CAS Latency = 6 tRP = 6 tRAS = 15 tRCD=6 DRAM CS[0] base 0x00000000 size 256MB DRAM CS[1] base 0x10000000 size 256MB DRAM Total size 512MB 16bit width Addresses 8M - 0M are saved for the U-Boot usage. Mem malloc Initialization (8M - 7M): Done NAND:512 MB Flash: 0 kB CPU : Marvell Feroceon (Rev 1) Streaming disabled Write allocate disabled Module 0 is RGMII USB 0: host mode PEX 0: interface detected no Link. PEX 1: interface detected no Link. Net: egiga0 [PRIME], egiga1 Hit any key to stop autoboot: 3 2 1 0 ### JFFS2 loading boot.img to 0x400000 Scanning ...
https://openwrt.org/toh/cisco/cisco_on-100_k9_v01?s%5B%5D=%2Ax86%2A&s%5B%5D=%2Ageneric%2A
Words ending in M (page 2)Words ending in M (page 2)
You need to find all english words ending in M ? We have that list and for sure you will find the word you are looking for. All these words ending in M are sorted by the number of points they give at Scrabble.
http://scrabble-words.net/ending-in/words-ending-in-M-2.html
Fórum / Old Punx fest 2012
Fórum. Old Punx fest - letní punkový open air festival se zcela novou a originální koncepcí. Vystoupí zde pouze legendy - kapely, které jsou na scéně déle než 18 let. To vše v novém areálu Milín..
http://oldpunx.cz/?page=forum&query=6966
Fórum / Old Punx fest 2012
Fórum. Old Punx fest - letní punkový open air festival se zcela novou a originální koncepcí. Vystoupí zde pouze legendy - kapely, které jsou na scéně déle než 18 let. To vše v novém areálu Milín..
http://oldpunx.cz/?page=forum&query=6775
Quick integral question | Physics Forums - The Fusion of Science and CommunityQuick integral question | Physics Forums - The Fusion of Science and Community
where n and m are just integers. These kind of integrals come up all the time in vector calculus and they take me ages to do. Is there a general method of doing them or a few common integrals i could learn? I end up having to apply about 3 trig identites and then sorting out the mess of resulting sinxs, cosx, cos2x ...
https://www.physicsforums.com/threads/quick-integral-question.165541/
Plus itPlus it
RESULTS The top two urine proteins with the highest difference in ratio of case subjects to control subjects were haptoglobin (8.7 times; P , 0.0001) and α-2-macroglobulin (5.7 times; P , 0.0001). In the cohort study, patients with baseline urinary haptoglobin ≥20 ng/min (haptoglobinuria) had a higher incidence of CRI than those without (hazard ratio [95% CI] 3.27 [1.41-7.58]; P = 0.006). The overall CRI rate was 3.2% for patients without haptoglobinuria or MAU, 9.5% for those with MAU, and 13.3% for those with haptoglobinuria. The highest rate for CRI (22.4%) was in patients with both MAU and haptoglobinuria (P , 0.001). ...
https://care.diabetesjournals.org/content/early/2016/11/29/dc16-1529
Criteria for the specific measurement of plasmin inhibitor activity using an enzymatic procedure - IFCCCriteria for the specific measurement of plasmin inhibitor activity using an enzymatic procedure - IFCC
In the measurement of plasmin inhibitor three reactions of plasmin are of importance. First is the reaction with the PB-form of the plasmin inhibitor. Second is the reaction with the NPB-form of the plasmin inhibitor and third the reaction with a 2 -macroglobulin. Using a small excess of plasmin ( approx. 1 m M), all three reactions take place as a second order reaction ([plasmin inhibitor] total approx. [plasmin] total ). At a plasmin inhibitor concentration of 1 m M gives this a velocity for the plasmin-PB-plasmin inhibitor complex formation of 27 s -1 . For the plasmin-NPB-plasmin inhibitor complex formation this is 0.2 s -1 and for the plasmin- a 2 -macroglobulin complex formation this is 1.0 s -1 . Expressed in ratios of the complexes this is 95.7% for the plasmin-PB-plasmin inhibitor complex, 0.7% for the plasmin-NPB-plasmin inhibitor complex and 3.6% for the plasmin- a 2 -macroglobulin complex ...
http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2002-vol-13/vol-13-no-2/criteria-for-the-specific-measurement-of-plasmin-inhibitor-activity-using-an-enzymatic-procedure/
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors ...The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors ...
Gelatinase B/matrix metalloproteinase-9 (MMP-9), a key regulator and effector of immunity, contains a C-terminal hemopexin domain preceded by a unique linker sequence of ?64 amino acid residues. This linker sequence is demonstrated to be an extensively O-glycosylated (OG) domain with a compact three-dimensional structure. The OG and hemopexin domains have no influence on the cleavage efficiency of MMP-9 substrates. In contrast, the hemopexin domain contains a binding site for the cargo receptor low density lipoprotein receptor-related protein-1 (LRP-1). Furthermore, megalin/LRP-2 is identified as a new functional receptor for the hemopexin domain of MMP-9, able to mediate the endocytosis and catabolism of the enzyme. The OG domain is required to correctly orient the hemopexin domain for inhibition by TIMP-1 and internalization by LRP-1 and megalin. Therefore, the OG and hemopexin domains down-regulate the bioavailability of active MMP-9 and the interactions with the cargo receptors are proposed ...
http://westminsterresearch.wmin.ac.uk/10377/
OriGene - LRP5 (NM 002335) Human ORF cDNA CloneOriGene - LRP5 (NM 002335) Human ORF cDNA Clone
LRP5 - LRP5 (GFP-tagged) - Human low density lipoprotein receptor-related protein 5 (LRP5) available for purchase from OriGene - Your Gene Company.
http://www.origene.com/Human_ORF_Clone/RG218864.aspx
Macroglobulin, Ask a Doctor about Macroglobulin - Doctors insight on HealthcareMagicMacroglobulin, Ask a Doctor about Macroglobulin - Doctors insight on HealthcareMagic
A macroglobulin is a plasma globulin of high molecular weight . Elevated levels of macroglobulins ( macroglobulinemia ) may cause manifestations of excess blood viscosity (as is the case for IgM...
https://www.healthcaremagic.com/topics/macroglobulin/237832
Toxins | Free Full-Text | Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands...Toxins | Free Full-Text | Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands...
Inhibition of AB5-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxins pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effective in vivo protection from Shiga toxin Type 1 (Stx1) is achieved by polymer-bound, heterobifunctional inhibitors-adaptors (PolyBAITs), which exhibit prolonged half-life in circulation and by mediating formation of face-to-face SAP-AB5 complexes, block receptor recognition sites and redirect toxins to the spleen and liver for degradation. Direct correlation between solid-phase activity and protective dose of PolyBAITs both in the cytotoxicity assay and in vivo indicate that the mechanism of protection from intoxication is inhibition of toxin binding to the host cell membrane. The polymeric scaffold influences the activity not only by clustering active binding fragments but also by sterically interfering with the
http://www.mdpi.com/2072-6651/3/9/1065/htm
Fibrinogen γ-chain dodecapeptide - CCP1202-5mg | acris-antibodies.com
Fibrinogen γ-chain dodecapeptide, 5 mg. The synthetic dodecapeptide HHLGGAKQAGDV represents the specific platelet receptor recognition site of the human fibrinogen �� chain (residues 400-411).
https://www.acris-antibodies.com/synthetic-peptides/fibrinogen-chain-dodecapeptide-ccp1202-5mg.htm
A Metabolomic Approach (1H HRMAS NMR Spectroscopy) Supported by Histology to Study Early Post-transplantation Responses in...A Metabolomic Approach (1H HRMAS NMR Spectroscopy) Supported by Histology to Study Early Post-transplantation Responses in...
Abstract. Intrahepatic transplantation of islets requires a lot of islets because more than 50% of the graft is lost during the 24 hours following transplantation. We analyzed, in a rat model, early post-transplantation inflammation using systemic inflammatory markers, or directly in islet-transplanted livers by immunohistochemistry. 1H HRMAS NMR was employed to investigate metabolic responses associated with the transplantation. Inflammatory markers (Interleukin-6, α2-macroglobulin) are not suitable to follow islet reactions as they are not islet specific. To study islet specific inflammatory events, immunohistochemistry was performed on sections of islet transplanted livers for thrombin (indicator of the instant blood-mediated inflammatory reaction (IBMIR)) and granulocytes and macrophages. We observed a specific correlation between IBMIR and granulocyte and macrophage infiltration after 12 h. In parallel, we identified a metabolic response associated with transplantation: after 12 h, ...
http://www.ijbs.com/v12p1168
Panza dIschia Hotels with Meeting Facilities- Meeting Hotels in Panza dIschia- Corporate Meeting Planning: Meetings and...Panza dIschia Hotels with Meeting Facilities- Meeting Hotels in Panza dIschia- Corporate Meeting Planning: Meetings and...
Meeting planners find Panza dIschia meeting hotel information for your next Panza dIschia meeting, conference, or event. Meeting room information for Panza dIschia hotels with meeting facilities. Find a meeting hotel in Panza dIschia by room amenities, services, size, price and location. Find convention centers and meeting locations by available resources and specifications
http://www.meetings-conventions.com/Meeting-Facilities/Panza-dIschia-Italy/Hotels
Bioline International Official Site (site up-dated regularly)Bioline International Official Site (site up-dated regularly)
Pulmonary tuberculosis (PTB) is global disease affecting about one third of the worlds population with its attendant mortality and morbidity. Acute phase proteins have been used in monitoring the progression of infections but not in relation to PTB in this environment. The levels of total protein, albumin, α-2-macroglobulin, transferrin, and haptoglobulin were determined in 23 patients with PTB and 17- age / sex matched PTB-free controls using spectrophotometric and immunodiffusion methods respectively. The result showed that α-2-macroglobulin was significantly raised in PTB patients compared with controls ( ...
http://www.bioline.org.br/abstract?id=md06029&lang=en
alpha2-M (alpha2-Macroglobulin)
1 front of precipitation against rabbit antisera to halpha2-M. Scientific note: Serum glycoprotein of MW approx. 800,000 daltons, containing 38 histidine residues. Two protomers of MW aprox. 370,000 daltons. Each protomer is formed by two sub-units of MW 185,000 daltons, linked by disulfide bridges. N-linked complex carbohydrate side chains ...
http://affiland.com/protein/humanmacroglob.htm
diglloyd blog: Grab em While You Can: Leica 28/2 Summicron, 35/2 Summicron, 50/1.4 Summilux
Watch my gear pages for in-stock status and easy-click links. (Various pages for different brands, etc). Be sure to refresh the page in your browser (cmd-R in some browsers).. Update (Wednesday): the 18/3.8, 21/3.4 and 24/3.8 are in stock. All three of those lenses are superb.. Update (Thursday): the 18/3.8 and 21/3.4 sold out yesterday, but the 24/3.8 Elmar-M is still available and if anything, its a little bit better than the outstanding 21/3.4 SEM. ALSO, a number of the Zeiss ZM lenses for Leica M are in stock. And the 18/3.8 popped back into stock.. .... As I write this, the very hard to get 50/1.4 Summilux is IN STOCK at B&H, along with the 28/2 Summicron and 35/2 Summicron.. Bookmark my Leica gear page for in-stock status and easy-click links.. Update: that 50/1.4 Sumilux lasted all of 1/2 hour. Watch my Leica gear page for status changes; most days it updates every 30 minutes (working hours) and I often see it update before the B&H in-stock email arrives. Ditto for all the other pages. ...
https://diglloyd.com/blog/2012/20120320_1-LeicaM.html
Jaimi (25) - Looking in Rosanna, Ivanhoe East, Ivanh... | Flatmates.com.auJaimi (25) - Looking in Rosanna, Ivanhoe East, Ivanh... | Flatmates.com.au
Looking anywhere north of the eastern but south of the ring road - pretty flexible!. Me (24, F) and my dog Tobias (1, M) are on the hunt for a queen size room with my own bathroom (preferably, but Im flexible on this) in a pet friendly house that has a bit of a backyard. Weve given our 4 weeks notice at our current place, so wanting to move before the end of Feb. More than happy to join a lease, or start a new one! Budget up to $200 a week or $240 for my own bathroom excl bills. To save you reading the novel below, both me and Toby are clean, friendly and respectful and enjoy watching sports over a bev! We have two solid incomes between us (both from me) and Toby will definitely keep you entertained with his antics!. About me ...
https://flatmates.com.au/F916663
CyFlow™ CD11b FITC | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry CanadaCyFlow™ CD11b FITC | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry Canada
Quantity100 testsVolume2.0 mLImmunogenHuman granulocytesBackground InformationCD11b (integrin αM subunit) is a 165-170 kDa type I transmembrane glyco…
https://ca.sysmex-flowcytometry.com/reagents/expanded-antibody-search/1687/cyflow-cd11b-fitc
Alpha-2-MacroglobulinAlpha-2-Macroglobulin
"A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor". Biochemistry ... α2-Macroglobulin (α2M), or alpha-2-macroglobulin, is a large (720 KDa) plasma protein found in the blood. It is mainly produced ... Stevenson, FT; Greene, S; Kaysen, GA (January 1998). "Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are ... "Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3". J. Biol. Chem. 264 (19): 11428 ...
https://en.wikipedia.org/wiki/Alpha-2-Macroglobulin
SDS-PAGESDS-PAGE
... for proteinuria evaluates the levels of various serum proteins in the urine, e.g. Albumin, Alpha-2-macroglobulin and ...
https://en.wikipedia.org/wiki/SDS-PAGE
A2ML1A2ML1
Alpha-2-macroglobulin-like 1 abbreviated as α2ML1 is a protein that in humans is encoded by the A2ML1 gene. α2ML1 is a large, ... "Entrez Gene: Alpha-2-macroglobulin-like 1". Galliano MF, Toulza E, Gallinaro H, Jonca N, Ishida-Yamamoto A, Serre G, Guerrin M ... This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several ... "The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies ...
https://en.wikipedia.org/wiki/A2ML1
LDL-receptor-related protein-associated proteinLDL-receptor-related protein-associated protein
It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density ... Jou YS, Goold RD, Myers RM (Nov 1994). "Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) ... coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the ... "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen". The ...
https://en.wikipedia.org/wiki/LDL-receptor-related_protein-associated_protein
TGF beta 2TGF beta 2
Comparison to the TGF-beta-alpha 2-macroglobulin interaction". Eur. J. Biochem. 221 (2): 687-93. doi:10.1111/j.1432-1033.1994. ...
https://en.wikipedia.org/wiki/TGF_beta_2
Acute-phase proteinAcute-phase protein
Alpha 2-macroglobulin and coagulation factors affect coagulation, mainly stimulating it. This pro-coagulant effect may limit ... December 1993). "Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in ...
https://en.wikipedia.org/wiki/Acute-phase_protein
Developmental HaemostasisDevelopmental Haemostasis
alpha-2-Macroglobulin (A2M): is also a major inhibitor of thrombin. It is present in 2-3 fold higher concentration during ... the functional role of alpha-2-macroglobulin and influence of Developmental Haemostasis. British Journal of Haematology, 138(3 ...
https://en.wikipedia.org/wiki/Developmental_Haemostasis
Interleukin-6 receptorInterleukin-6 receptor
"Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin". Biol. Chem. Hoppe-Seyler. 373 (7): ... Kluck PM, Wiegant J, Jansen RP, Bolk MW, Raap AK, Willemze R, Landegent JE (1993). "The human interleukin-6 receptor alpha ... The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528-35. doi:10.1074/jbc. ...
https://en.wikipedia.org/wiki/Interleukin-6_receptor
Low-density lipoprotein receptor-related protein 8Low-density lipoprotein receptor-related protein 8
ApoER2 splice variants can act as a receptor for alpha-2-macroglobulin which can have a role in clearance of alpha-2- ... which is controlled by proteolytic inhibitors such as alpha-2-macroglobulin. Studies have shown that a high presence of alpha-2 ... Isolation of cDNA encoding proteins associated with Aβ was used to discover alpha-2-macroglobulin. These discoveries may link ... alpha-2-macroglobulin and its receptors, one of them being ApoER2, to Alzheimer's disease. ApoER2 interaction with reelin and ...
https://en.wikipedia.org/wiki/Low-density_lipoprotein_receptor-related_protein_8
George StoufferGeorge Stouffer
Stouffer, G. A.; LaMarre, J.; Gonias, S. L.; Owens, G. K. (August 25, 1993). "Activated alpha 2-macroglobulin and transforming ... Stouffer attended the University of Maryland School of Medicine and was inducted into the Alpha Omega Alpha honor society. He ...
https://en.wikipedia.org/wiki/George_Stouffer
Glucocorticoid receptorGlucocorticoid receptor
... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes & Development. 17 (20): 2564-2577. ... The role of alpha and beta isoforms of the glucocorticoid receptor]". Archivos de Bronconeumologia. 38 (9): 436-440. doi: ... Heck S, Bender K, Kullmann M, Göttlicher M, Herrlich P, Cato AC (August 1997). "I kappaB alpha-independent downregulation of NF ...
https://en.wikipedia.org/wiki/Glucocorticoid_receptor
STAT3STAT3
... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes & Development. 17 (20): 2564-77. ... Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y (May 2003). "Opposing effects of PML and PML/RAR alpha ... "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". ...
https://en.wikipedia.org/wiki/STAT3
LRP1LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein ... "The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine ... The extracellular domain of LRP1 is the alpha-chain, which comprises four ligand-binding domains (numbered I-IV) containing two ... LRP1 has been shown to interact with: A2-Macroglobulin, β-amyloid precursor protein, APBB1, APOE, Aprotinin, C1S/C1q inhibitor ...
https://en.wikipedia.org/wiki/LRP1
Lipoprotein lipaseLipoprotein lipase
"The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine ... domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP ...
https://en.wikipedia.org/wiki/Lipoprotein_lipase
Withaferin AWithaferin A
Anti-inflammatory property of withaferin A has been attributed to its ability to suppress alpha-2 macroglobulin, NF-κB and AP1 ... It binds to intermediate filament protein, vimentin by covalently modifying its highly conserved cysteine residue in alpha- ...
https://en.wikipedia.org/wiki/Withaferin_A
KLK7KLK7
... elafin and alpha-2-Macroglobulin-like 1. Both Zn2+ and Cu2+ ions are also able to inhibit KLK7. KLK7 is a chymotrypsin-like ... "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis". The Journal of Biological ...
https://en.wikipedia.org/wiki/KLK7
Nephrotic syndromeNephrotic syndrome
... such as alpha-2 macroglobulin and lipoproteins. An increase in the latter can cause the hyperlipidemia associated with this ...
https://en.wikipedia.org/wiki/Nephrotic_syndrome
CD109CD109
2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing ... 2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family". Gene. 327 (2): 171-83. doi:10.1016 ...
https://en.wikipedia.org/wiki/CD109
POTEBPOTEB
... and alpha-2-macroglobulin. This data is based on affinity capture- mass spectrometry. POTEB expression is low or completely ... However, there is unpublished data suggesting an interaction between POTEB and alpha-1-B glycoproteins, APOBEC1 complementation ...
https://en.wikipedia.org/wiki/POTEB
Disease-modifying osteoarthritis drugDisease-modifying osteoarthritis drug
Zhang Y, Wei X, Browning S, Scuderi G, Hanna LS, Wei L (July 2017). "Targeted designed variants of alpha-2-macroglobulin (A2M) ... "Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritis of the Knee With Alpha-2 Macroglobulin" at ...
https://en.wikipedia.org/wiki/Disease-modifying_osteoarthritis_drug
Pancreatic elastasePancreatic elastase
Alpha 1-antitrypsin and alpha-2-macroglobulin are human serum protease inhibitors that completely inhibit the general ...
https://en.wikipedia.org/wiki/Pancreatic_elastase
Hep G2Hep G2
... alpha 2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen.[citation needed] They have been grown successfully in ...
https://en.wikipedia.org/wiki/Hep_G2
Placental alpha microglobulin-1 (PAMG-1)Placental alpha microglobulin-1 (PAMG-1)
Placental alpha macroglobulin-1 (PAMG-1) has been the subject of over 20 clinical investigations, the majority of which have ... Placental alpha microglobulin-1 (PAMG-1) is a human protein that was first isolated in 1975 from amniotic fluid. PAMG-1 is an ... Lee, S. E.; Park, J. S.; Norwitz, E. R.; Kim, K. W.; Park, H. S.; Jun, J. K. (2007). "Measurement of placental alpha- ... PAMG-1 was originally referred to as specific alpha-1 globulin of placenta. PAMG-1 is present in blood and the amniotic fluid ...
https://en.wikipedia.org/wiki/Placental_alpha_microglobulin-1_(PAMG-1)
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... alpha 1-antichymotrypsin MeSH D12.776.377.715.085.085 - alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins ... alpha-macroglobulins See List of MeSH codes (D12.776.395). MeSH D12.776.402.150.100.200 - chimerin 1 MeSH D12.776.402.150. ... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
List of MeSH codes (D12.776.124)List of MeSH codes (D12.776.124)
... alpha-macroglobulins MeSH D12.776.124.790.720.100.500 - pregnancy-associated alpha 2-macroglobulins The list continues at List ... alpha 1-antichymotrypsin MeSH D12.776.124.790.106.085 - alpha 1-antitrypsin MeSH D12.776.124.790.106.100 - alpha-macroglobulins ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 - immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 - ... immunoglobulin alpha-chains MeSH D12.776.124.790.651.114.619.251 - immunoglobulin d MeSH D12.776.124.790.651.114.619.251.500 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
Whale barnacleWhale barnacle
... so it may be that whale barnacles use the alpha-2-macroglobulin, a plasma protein of the blood common in vertebrates. After ...
https://en.wikipedia.org/wiki/Whale_barnacle
FibroTestFibroTest
Alpha-2-macroglobulin, Haptoglobin, Apolipoprotein A1, Gamma-glutamyl transpeptidase (GGT), Total bilirubin, and Alanine ... FibroSure uses quantitative results of five serum biochemical markers, α2-macroglobulin, haptoglobin, apolipoprotein A1, ...
https://en.wikipedia.org/wiki/FibroTest
Protease inhibitor (biology)Protease inhibitor (biology)
... alpha-2-Macroglobulin Pefabloc SC Pepstatin PMSF (phenylmethanesulfonyl fluoride) TLCK Trypsin inhibitors Kunitz domain ... The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ... In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this ...
https://en.wikipedia.org/wiki/Protease_inhibitor_(biology)
RheopheresisRheopheresis
... alpha-2-macroglobulin, von Willebrand factor, LDL cholesterol and immunoglobulin M. It is an experimental treatment for dry age ...
https://en.wikipedia.org/wiki/Rheopheresis
Pregnancy zone proteinPregnancy zone protein
... alpha-2-macroglobulin like, Xh-antigen, Schwangerschaftsprotein-3, Pα-1, pregnancy-associated α-macroglobulin, pregnancy- ... PZP is part of the alpha-2 globulin family of proteins. It is often associated with pregnancy, during which it can be the most ...
https://en.wikipedia.org/wiki/Pregnancy_zone_protein
Index of biochemistry articlesIndex of biochemistry articles
... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ... alpha adrenergic receptor - alpha helix - alpha-1 adrenergic receptor - alpha-2 adrenergic receptor - ... transforming growth factor alpha - transforming growth factor beta - transforming growth factor beta receptor - transient ... interferon-alpha - interferon-beta - interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - ...
https://en.wikipedia.org/wiki/Index_of_biochemistry_articles
Pharmacology of bicalutamidePharmacology of bicalutamide
5 alpha-dihydrotestosterone and [3H]cortisol binding to plasma proteins". J. Steroid Biochem. 33 (2): 251-5. doi:10.1016/0022- ... and as a ligand and inhibitor of α2-macroglobulin. The pharmacokinetics of bicalutamide are unaffected by food, age, body ... role of 3 alpha- and 3 beta-androstanediols". Biology of Reproduction. 51 (3): 562-71. doi:10.1095/biolreprod51.3.562. PMID ...
https://en.wikipedia.org/wiki/Pharmacology_of_bicalutamide
Gel electrophoresis of proteinsGel electrophoresis of proteins
α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ... The alpha (α) band consists of two parts, 1 and 2: α1 - α1-antitrypsin, α1-acid glycoprotein. ...
https://en.wikipedia.org/wiki/Gel_electrophoresis_of_proteins
Alpha globulinAlpha globulin
... amyloid A Alpha 1-lipoprotein Haptoglobin Alpha-2u globulin α2-macroglobulin Ceruloplasmin Thyroxine-binding globulin Alpha 2- ... The alpha globulins typically have molecular weights of around 93 kDa. Alpha globulins include certain hormones, proteins that ... antiplasmin Protein C Alpha 2-lipoprotein Angiotensinogen Cortisol binding globulin Vitamin D-binding protein Alpha-Globulins ... Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions ...
https://en.wikipedia.org/wiki/Alpha_globulin
Affinity chromatographyAffinity chromatography
Lectins, such as concanavalin A are proteins which can bind specific alpha-D-mannose and alpha-D-glucose carbohydrate molecules ... Affinity purification of albumin and macroglobulin contamination is helpful in removing excess albumin and α2-macroglobulin ...
https://en.wikipedia.org/wiki/Affinity_chromatography
Serum protein electrophoresisSerum protein electrophoresis
Alpha-2 macroglobulin may be elevated in children and the elderly. This is seen as a sharp front to the alpha-2 band. AMG is ... Stevenson, FT; Greene, S; Kaysen, GA (January 1998). "Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are ... The alpha-1 fraction does not disappear in alpha 1-antitrypsin deficiency, however, because other proteins, including alpha- ... resulting in a typical elevation in the alpha-2 zone during inflammation. A normal alpha-2 and an elevated alpha-1 zone is a ...
https://en.wikipedia.org/wiki/Serum_protein_electrophoresis
MicroglobulinMicroglobulin
It can be contrasted to macroglobulin., Examples include: Beta-2 microglobulin Alpha-1-microglobulin "Definition: microglobulin ...
https://en.wikipedia.org/wiki/Microglobulin
Follicular lymphomaFollicular lymphoma
... alpha-induced protein 3 which inhibits the activation of NF-κB, blocks cell death due to apoptosis, and regulates lymphocyte- ... high levels of Beta-2 macroglobulin or bone marrow involvement). The combination of lenalidomide with rituximab has shown good ...
https://en.wikipedia.org/wiki/Follicular_lymphoma
MMP7MMP7
MMP4 is inhibited by α 2-macroglobulin and TIMP. The inhibition of MMP7 activity commonly relies on metal-chelating agents ... TNF-alpha, RAS, heparin-binding EGF, IGF binding proteins and plasminogen. Further, this process promotes epithelial cell ...
https://en.wikipedia.org/wiki/MMP7
Metalloprotease inhibitorMetalloprotease inhibitor
α2-Macroglobulin (α2M) is a protease inhibitor which inhibits activated MMPs. α2M and MMP form a complex which is able to ... The metalloproteinases that release TNF-alpha, TNF-II, L-selectin, IL-1-RII and IL-6 are for example not inhibited by ... α2-macroglobulin does not inhibit the activation of MMPs or the MMPs themselves. It entraps proteinases like MMPs and forms a ... α2-macroglobulin is an abundant plasma protein that acts in tissue fluids. The plasma glycoprotein consists of four subunits. ...
https://en.wikipedia.org/wiki/Metalloprotease_inhibitor
Alpha-2-Macroglobulin | ARUP Laboratories Test DirectoryAlpha-2-Macroglobulin | ARUP Laboratories Test Directory
May be used as a marker of membrane permeability in urine or as an indirect marker for liver fibrosis. ||Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Serum Separator Tube (SST).
https://ltd.aruplab.com/Tests/Pub/0050005
IMSEAR at SEARO: Alpha-2 macroglobulin--new tumour marker?
Alpha-2 macroglobulin--new tumour marker? Journal of the Association of Physicians of India. 1987 Apr; 35(4): 257. ...
https://imsear.searo.who.int/handle/123456789/90665?locale=zh_TW
Alpha-2-Macroglobulin (A2M) InjectionsAlpha-2-Macroglobulin (A2M) Injections
... may potentially halt the degenerative process in arthritis. Studies have suggested that ... Alpha-2-Macroglobulin, or A2M, is a naturally occurring molecule found in your blood that acts as a powerful protector against ... Alpha-2-Macroglobulin, or A2M Injections uses proven scientific techniques and natural healing methods to treat arthritis at ... Your liver actually makes large quantities of Alpha-2-Macroglobulin and it circulates in your blood stream in reasonably high ...
https://www.bostonbiologic.com/our-treatments/alpha-2-macroglobulin/
Bovine alpha 2 Macroglobulin ELISA Kit | Biorbyt
Alpha 2M ELISA Kit, Alpha-2-M ELISA Kit, Alpha-2-macroglobulin ELISA Kit, C3 and PZP-like alpha-2-macroglobulin domain- ... Youre reviewing:Bovine alpha 2 Macroglobulin ELISA Kit - orb403037. Your Rating. 1 star. 2 stars. 3 stars. 4 stars. 5 stars. ... click to expand) A2M ELISA Kit, Alpha 2 M ELISA Kit, ... Bovine alpha 2 Macroglobulin ELISA Kit Catalog Number: ...
https://www.biorbyt.com/bovine-alpha-2-macroglobulin-e-orb403037.html
Cytonics - Alpha-2-Macroglobulin (A2M) based therapies for osteoarthritis.Cytonics - Alpha-2-Macroglobulin (A2M) based therapies for osteoarthritis.
Cytonics corporation is a R&D biotech leader specializing in developing diagnostic and Alpha-2-Macroglobulin (A2M) therapies ... Cytonics has developed a lead recombinant drug candidate, a variant of human alpha-2-macroglobulin that possesses a unique and ... Alpha-2 Macroglobulin (A2M), which protects cartilage from degradation and can alleviate joint pain. We developed an autologous ... "I have been using Cytonics alpha2- macroglobulin kits to treat various joint pains mostly in the knee. This is part of my ...
https://cytonics.com/
Mouse Alpha-2-macroglobulin-P(A2MP) ELISA kit | Doron ScientificMouse Alpha-2-macroglobulin-P(A2MP) ELISA kit | Doron Scientific
Specificity of age-related carbonylation of plasma proteins in the mouse and ratSpecificity of age-related carbonylation of plasma proteins in the mouse and rat
In the rat, albumin and a 167-kDa protein, alpha1-macroglobulin (alpha-1M), showed significant age-dependent accrual of ... However, neither transferrin nor alpha-1M were carbonylated in the plasma of Rhesus monkey. Albumin was the only protein that ...
https://pubmed.ncbi.nlm.nih.gov/11795905/?dopt=Abstract
Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic...Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic...
Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however ... Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic ... Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in typ ...
https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1410223
C3 gene: MedlinePlus GeneticsC3 gene: MedlinePlus Genetics
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1. *C3a ...
https://medlineplus.gov/genetics/gene/c3/
Interaction of Silver Nanoparticles with Human Alpha-2-macroglobulin: Biochemical and Biophysical Investigation | Siddiqui |...Interaction of Silver Nanoparticles with Human Alpha-2-macroglobulin: Biochemical and Biophysical Investigation | Siddiqui |...
Interaction of Silver Nanoparticles with Human Alpha-2-macroglobulin: Biochemical and Biophysical Investigation ... Inactivation of alpha-2-macroglobulin by photo-illuminated gallic acid. J Fluoresc. 2019; 29(4): 969-79, CrossRef. ... Deciphering the binding of dutasteride with human alpha-2-macroglobulin: Molecular docking and calorimetric approach. Int J ... Characterization of the binding between anti-tumor drug 5-fluorouracil and human alpha-2-macroglobulin: Spectroscopic and ...
https://cellbiopharm.com/ojs/index.php/MCBS/article/view/281
CD109 (CD109 Antigen, 150kD TGF-beta-1-binding Protein, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 7,...CD109 (CD109 Antigen, 150kD TGF-beta-1-binding Protein, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 7,...
CD109 (CD109 Antigen, 150kD TGF-beta-1-binding Protein, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 7, ... CD109 (CD109 Antigen, 150kD TGF-beta-1-binding Protein, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 7, ...
https://labstore.ru/en/catalog/antitela-3/cd109-cd109-antigen-150kd-tgf-beta-1-binding-protein-c3-and-pzp-like-alpha-2-macroglobulin-domain-containing-protein-7-platelet-specific-gov-antigen-p180-r150-cpamd7-dkfzp762l1111-flj38569-flj41966-rp11-525g31-maxlig-1/100-mkl/
Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin...Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin...
Transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations [arithmetic mean (±SD)] ... Reference values of cord blood transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin ...
https://avesis.ktu.edu.tr/yayin/55767798-2199-4637-964d-d7a47646fcaa/reference-values-of-cord-blood-transferrin-ceruloplasmin-alpha-1-antitrypsin-prealbumin-and-alpha-2-macroglobulin-concentrations-in-healthy-term-newborns
PDB 4ZJG | Chain CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1. | 4ZJG A...PDB 4ZJG | Chain CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1. | 4ZJG A...
CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1. - 4ZJG , canSARS ... CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1. ... CRYSTAL STRUCTURE OF NATIVE ALPHA-2-MACROGLOBULIN FROM ESCHERICHIA COLI SPANNING DOMAINS MG0-NIE-MG1. ...
https://corona-2.cansar.icr.ac.uk/structure/4ZJG/3d/4ZJG_A
Viral Hepatitis Workup: Approach Considerations, Hepatitis A, Hepatitis BViral Hepatitis Workup: Approach Considerations, Hepatitis A, Hepatitis B
HepaScore is based on levels of hyaluronic acid, alpha-2 macroglobulin, gamma glutamyl transferase (GGT), and total bilirubin, ... HCV FibroSURE measures alpha-2 macroglobulin, haptoglobin, GGT, bilirubin, ALT, and apolipoprotein A1 ... FIBROSpect II uses measurements of hyaluronic acid, tissue inhibitor of metalloproteinase-1 (TIMP-1) and alpha-2 macroglobulin ... Pegylated interferon alpha-2b as monotherapy or in combination with ribavirin in chronic hepatitis delta. Hepatology. 2006 Sep ...
https://www.medscape.com/answers/775507-38329/how-is-liver-stiffness-estimated-in-the-evaluation-of-hepatitis-c-virus-hcv-infection
GenAge Human Genes: List of EntriesGenAge Human Genes: List of Entries
alpha-2-macroglobulin. 5. 21. ABL1. 78. ABL proto-oncogene 1, non-receptor tyrosine kinase. 5. 69. ... transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha). 7. 30. ... eukaryotic translation elongation factor 1 alpha 1. 5. 43. EEF1E1. 266. eukaryotic translation elongation factor 1 epsilon 1. 3 ... platelet-derived growth factor receptor, alpha polypeptide. 4. 17. PDGFRB. 51. platelet-derived growth factor receptor, beta ...
https://genomics.senescence.info/genes/allgenes.php
MMRRC:044056-MUMMRRC:044056-MU
Name: alpha-2-macroglobulin. Synonyms: A2mp. Type: Gene. Species: Mus musculus (mouse) ... Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC ... Synonyms: meprin A alpha-subunit, Mep-1a, Mep-1, meprin alpha, Mep1 ... Name: myosin, heavy polypeptide 6, cardiac muscle, alpha. ...
https://www.mmrrc.org/catalog/sds.php?mmrrc_id=44056
Biology, Administration, and Therapy of Small Cell Lung Most cancer - Department of Developmental & Cell BiologyBiology, Administration, and Therapy of Small Cell Lung Most cancer - Department of Developmental & Cell Biology
Rat alpha 2-Macroglobulin (A2M) ELISA kit 96 tests, Quantitative. 610-420-A2M Alpha Diagnostics 1 Kit. ...
https://www.ucidevcell.org/exosomes/
Plasma proteomic profiles of bovine growth hormone transgenic mice as they agePlasma proteomic profiles of bovine growth hormone transgenic mice as they age
Finally, alpha-2 macroglobulin (seven isoforms) was altered in an isoform-specific manner with two isoforms increased and two ...
https://pubmed.ncbi.nlm.nih.gov/21365322/
SCOP 1.55: Species: Human (Homo sapiens)SCOP 1.55: Species: Human (Homo sapiens)
Class a: All alpha proteins [46456] (138 folds). *. Fold a.13: alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 ... Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.13.1.1 alpha-2-Macroglobulin receptor associated protein (RAP) ... More info for Species Human (Homo sapiens) [TaxId:9606] from a.13.1.1 alpha-2-Macroglobulin receptor associated protein (RAP) ... Species Human (Homo sapiens) [TaxId:9606] from a.13.1.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1 ...
http://scop.berkeley.edu/sunid=47048&ver=1.55
PDF) Glutathione Metabolism and Its Implications for HealthPDF) Glutathione Metabolism and Its Implications for Health
Ceruloplasmin, alpha-2-macroglobulin and alpha-1-acid glycoprotein were higher in TNF-treated rats than in saline controls in ... alpha-2-Macroglobulin concentration was lower in all animals fed low protein diets than in those fed the high protein diet. ... alpha-1-Acid glycoprotein was lowest in groups fed cysteine-supplemented diets and highest in the glycine-supplemented group.( ... or a high protein diet for 1 wk before injection with tumor necrosis factor alpha (TNF) or saline. The high protein diet-fed ...
https://www.researchgate.net/publication/6686626_Glutathione_Metabolism_and_Its_Implications_for_Health
Natural Proteins | Recombinant Proteins | Adooq BioscienceNatural Proteins | Recombinant Proteins | Adooq Bioscience
Macroglobulin Alpha-2 Human Learn More * Quick View Hemopexin Human Catalog No. AP2533. ...
https://www.adooq.com/natural-proteins.html
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
C3 and PZP like, alpha-2-macroglobulin domain containing 8. protein-coding. ...
https://www.genscript.com/gene/9823/sus-scrofa?search=c
Mouse Beta-2-Microglobulin ELISA Kit (ab223590) | AbcamMouse Beta-2-Microglobulin ELISA Kit (ab223590) | Abcam
Beta-2-Microglobulin can dissociate from the MHC and circulate in complex with alpha 2-Macroglobulin. ...
https://www.abcam.com/mouse-beta-2-microglobulin-elisa-kit-ab223590.html?productwalltab=abreviews
Donkey anti-Sheep IgG Secondary Antibody [HRP (Horseradish Peroxidase)] (HAF016): Novus BiologicalsDonkey anti-Sheep IgG Secondary Antibody [HRP (Horseradish Peroxidase)] (HAF016): Novus Biologicals
St Jean A, Swofford C, Panteli J, Brentzel Z, Forbes N Bacterial delivery of Staphylococcus aureus alpha-hemolysin causes ...
https://www.novusbio.com/products/igg-antibody_haf016
LitteratureLitterature
Unique features of a Pseudomonas aeruginosa {alpha}2-macroglobulin homolog.. Journal: mBio (Aug 2013). Authors: Robert-Genthon ... Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction. Journal: Movement Disorders (April 2022). Authors: ... alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation.. ... The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent ...
https://www.covalab.com/eu/support-litterature
SMART: LDLa domain annotationSMART: LDLa domain annotation
The overall structure of gp330 is similar to that of the LDLR-related protein (LRP)/alpha 2-macroglobulin receptor and shows ... including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in ... including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in ... EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN. ...
http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&ACC=SM00192
WHO EMRO | C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia? |...
Diagnostic and prognostic utility of C-reactive protein, alpha-1-antitrypsin and alpha-2-macroglobulin in neonatal sepsis: a ...
http://www.emro.who.int/emhj-volume-15-2009/volume-15-issue-2/article3.html
Complement C3d Human Enzyme | C3d Protein | ProSpecComplement C3d Human Enzyme | C3d Protein | ProSpec
Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1. ...
https://www.prospecbio.com/c3d-human
Plasma Proteins - α2 Macroglobulin (A2M) - scrippslabs.comPlasma Proteins - α2 Macroglobulin (A2M) - scrippslabs.com
α2 Macroglobulin. α2 Macroglobulin (A2M) belongs to the α2-globulin family of human plasma proteins and functions as an ...
https://scrippslabs.com/alpha-2-macroglobulin/
Alpha2-macroglobulinProteinsProteinPrealbuminMoleculeInjectionsTransferrinInhibitsOsteoarthritisGeneAlzheimer'sHumanAssociationBloodMajorMouseProteinSerumProteinasePlatelet Rich PlasmaGenePeptideWestern blotHaptoglobinTrypsinProtease inhibitorSubstanceInhibitorInhibitorsProteasesInteractionBoundDeletionNeuronalConcentrationsCleavageTumorInterleukinComplexInhibitoryInhibitionAcuteFormPatientsFibronectinElectrophoresisTissueGrowthIncludeProducts
Alpha2-macroglobulin4
  • I have been using Cytonics' alpha2- macroglobulin kits to treat various joint pains mostly in the knee. (cytonics.com)
  • We postulate that very large macromolecules like IgM will not pass the glomerular filter at all under normal conditions, whereas the urine concentration of alpha2-macroglobulin will normally be extremely low. (lu.se)
  • Alpha2-macroglobulin exon 24 (Val-1000-Ile) polymorphism is not associated with late-onset sporadic Alzheimer's dementia in the Hungarian population. (cdc.gov)
  • Neither the tumor necrosis factor alpha-308 A/G polymorphism nor the alpha2-macroglobulin polymorphism was associated with late-onset Alzheimer's disease in the Chinese population. (cdc.gov)
Proteins9
  • Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl-heidelberg.de)
  • α 2 Macroglobulin (A2M) belongs to the α 2-globulin family of human plasma proteins and functions as an inhibitor of all types of proteases. (scrippslabs.com)
  • The proteins studied varied in radius from 16.2 A (Beta 2-microglobulin) to 90 A (alpha 2-macroglobulin). (lu.se)
  • 2005) [ 11 ] found that innate immune and amyloidogenic proteins were detected more frequently in the cerebrospinal fluid of patients compared to controls, and that the presence of one or more of a subset of proteins (α-1-macroglobulin, amyloid precursor-like protein 1, keratin 16, orosomucoid 2, and pigment epithelium-derived factor) predicted ME/CFS status with 80% accuracy. (plos.org)
  • A number of other proteins namely thyroxine binding globulin, GC globulin and alpha 2HS-glycoprotein appeared in bile at concentrations greater than those expected if entry is by the sieving mechanism. (bmj.com)
  • It involves injecting alpha-2 macroglobulin - a naturally-occurring molecule - into the body to eliminate the proteins that cause joint pain. (sport-topics.com)
  • Mass spectrometric analysis of the changes observed in two-dimensional electrophoresis identified a number of proteins previously implicated in the disease pathology, including complement factor H (CFH) precursor and alpha-2-macroglobulin (alpha-2M). (ox.ac.uk)
  • These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as alpha-2M may be a specific markers of this illness. (ox.ac.uk)
  • The proteolytic activity of PSA in blood is inhibited by the irreversible formation of complexes with protease inhibitors such as alpha-1-antichymotrypsin, alpha-2-macroglobulin, and other acute phase proteins. (hancockregionalhospital.org)
Protein3
  • Discovery of FAC as a biomarker for osteoarthritis led to the identification of a naturally-occurring blood protein, Alpha-2 Macroglobulin (A2M), which protects cartilage from degradation and can alleviate joint pain. (cytonics.com)
  • In the rat, albumin and a 167-kDa protein, alpha1-macroglobulin (alpha-1M), showed significant age-dependent accrual of carbonylation. (nih.gov)
  • G protein subunit alpha i3 [Source:H. (gsea-msigdb.org)
Prealbumin1
  • Transferrin, ceruloplasmin, alpha-1 antitrypsin, prealbumin, and alpha-2 macroglobulin concentrations [arithmetic mean (±SD)] were found to be 199.7 (±34.6) mg/dl, 14.6 (±4.0) mg/dl, 160.2 (±23.6) mg/dl, 11.9 (±2.2) mg/dl, and 284.6 (±44.4) mg/dl, respectively. (ktu.edu.tr)
Molecule2
  • Alpha-2-Macroglobulin, or A2M, is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown. (bostonbiologic.com)
  • This molecule, alpha-2-macroglobulin (A2M), is found within. (cytonics.com)
Injections1
  • Alpha-2-Macroglobulin, or A2M Injections uses proven scientific techniques and natural healing methods to treat arthritis at its source. (bostonbiologic.com)
Transferrin1
  • However, neither transferrin nor alpha-1M were carbonylated in the plasma of Rhesus monkey. (nih.gov)
Inhibits1
  • Cytonics' recombinant drug development program is anchored in robust preclinical data indicating that the proteinase inhibitor alpha-2-macroglobulin critically inhibits cartilage breakdown in models of osteoarthritis. (cytonics.com)
Osteoarthritis1
  • Alpha-2-Macroglobulin (A2M) based therapies for osteoarthritis. (cytonics.com)
Gene1
  • Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients. (cdc.gov)
Alzheimer's2
  • Using semi-quantitative immunoblotting, the elevation of CFH and alpha-2M was shown to be specific for Alzheimer's disease and to correlate with disease severity although alternative assays would be necessary to improve sensitivity and specificity. (ox.ac.uk)
  • Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease. (cdc.gov)
Human2
  • Cytonics has developed a lead recombinant drug candidate, a variant of human alpha-2-macroglobulin that possesses a unique and improved bioactivity profile. (cytonics.com)
  • Present study investigated the interaction of chemically synthesized AgNPs with human major antiproteinase alpha-2-macroglobulin (α2M). (cellbiopharm.com)
Association1
  • On the lack of a clear-cut association between alpha-2-macroglobulin deletion and the risk of Alzheimer disease in Poland. (cdc.gov)
Blood1
  • Your liver actually makes large quantities of Alpha-2-Macroglobulin and it circulates in your blood stream in reasonably high quantities. (bostonbiologic.com)
Major1
  • The major form of PSA is believed to be enveloped by alpha-2 macroglobulin. (cdc.gov)
Mouse1
  • Finally, alpha-2 macroglobulin (seven isoforms) was altered in an isoform-specific manner with two isoforms increased and two decreased in bGH mouse plasma compared to controls. (nih.gov)
Protein11
  • Alpha-2-Macroglobulin (A2M) is a major plasma protein in humans with various functions including ion transport, carrier protein, and the inhibition of proteinases. (q2labsolutions.com)
  • Human alpha-2-macroglobulin is a large plasma protein composed of four identical subunits of 180 kDa and is present in human plasma at concentrations ranging from 2 to 5 uM. (allcovered.io)
  • The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. (nih.gov)
  • A LDL-receptor related protein involved in clearance of chylomicron remnants and of activated ALPHA-MACROGLOBULINS from plasma. (umassmed.edu)
  • Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
  • The clearance of the FVIIIa heterodimer was inhibited by the alpha-2-macroglobulin receptor-associated protein (RAP), which is a universal ligand of the LDLR family. (nih.gov)
  • Gligorijević, N. Antipsychotic Clozapine Binding to Alpha-2-Macroglobulin Protects Interacting Partners against Oxidation and Preserves the Anti-Proteinase Activity of the Protein. (ac.rs)
  • 2 -macroglobulin as the most important anti-elastase protein in aortic tissue. (kiev.ua)
  • Research has indicated that oral proteases bound to alpha-II macroglobulins are capable of digesting protein pathogens in the blood, thus supporting the immune system. (mysupplementrd.com)
  • The proteins were α-1-macroglobulin, amyloid precursor-like protein 1, keratin 16, orosomucoid 2 and pigment epithelium-derived factor. (biomedcentral.com)
  • complement component 4 binding protein, alpha.C4BP.complement component 4 binding protein, alpha. (stanford.edu)
Serum7
  • Preparative isoelectric focusing of human serum isolated inhibitory fractions containing these same alpha globulins. (ajtmh.org)
  • 1. [Diagnostic value of serum level of alpha 2-macroglobulin-trypsin complex in pancreatic diseases using a colorimetric assay with a synthetic chromogenic substrate]. (nih.gov)
  • 4. Serum alpha 2-macroglobulin-trypsin complex and early recognition of severe acute pancreatitis after endoscopic retrograde pancreatography. (nih.gov)
  • 18. [alpha 2-Macroglobulin in serum and plasma: reference values with carbobenzoxy-valyl-glycyl-arginine-p-nitroanilide, a chromogenic substrate]. (nih.gov)
  • Now, for Alpha, because he's little bit older, he's fighting mother nature like a kung fu ninja - so he applies a nighttime super serum - Tiege Hanley's anti aging Super Serum. (antiaginghelper.com)
  • Taken together, our findings suggest that Kallistatin and α-2-macroglobulin are potential serum biomarkers for both AAA and TAA and TAA, respectively. (biomedcentral.com)
  • 2 - macroglobulin in blood serum and aortic tissues has been established. (kiev.ua)
Proteinase8
  • 16. Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. (nih.gov)
  • 20. The trypsin-inhibitory efficiency of human alpha 2-macroglobulin in the presence of alpha 1-proteinase inhibitor: evidence for the formation of an alpha 2-macroglobulin--alpha 1-proteinase inhibitor complex. (nih.gov)
  • Treatment of the human plasma proteinase inhibitor alpha 2-macroglobulin (alpha 2M) with proteinase results in conformational changes in the inhibitor and subsequent activation and cleavage of the internal thiolester bonds of alpha 2M. (duke.edu)
  • Previous studies from this laboratory have shown that cross-linking the alpha 2M subunits with cis-dichlorodiammineplatinum(II) (cis-DDP) prevents the proteinase-induced conformational changes which lead to the activation and cleavage of the internal thiolester bonds of alpha 2M. (duke.edu)
  • In addition, cis-DDP treatment prevents the proteinase- or CH3NH2-induced conformational changes in alpha 2M which lead to a 'slow' to 'fast' change in nondenaturing polyacrylamide gel electrophoresis. (duke.edu)
  • In this paper, we demonstrate that treatment of alpha 2M with dithiobis(succinimidyl propionate) (DSP) also results in cross-linking of the subunits of alpha 2M with concomitant loss of proteinase inhibitory activity. (duke.edu)
  • Although proteinase is not inhibited by DSP-treated alpha 2M, bait region specific proteolysis of the alpha 2M subunits still occurs. (duke.edu)
  • Unlike cis-DDP-treated alpha 2M, however, incubation of DSP-treated alpha 2M with proteinase does not prevent the bait region cleavage dependent conformational changes which lead to activation and cleavage of the internal thiolester bonds in alpha 2M. (duke.edu)
Platelet Rich Plasma1
  • These may include Platelet Rich Plasma and A2M (alpha 2 macroglobulin) therapy. (regenpainnynj.com)
Gene4
  • Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. (nih.gov)
  • Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients. (cdc.gov)
  • This gene encodes a member of the alpha-macroglobulin superfamily. (creative-biolabs.com)
  • The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. (wikidata.org)
Peptide1
  • 14. Cleavage of peptide hormones by alpha 2-macroglobulin-trypsin complex and its relation to the pathogenesis and chemotherapy of acute pancreatitis. (nih.gov)
Western blot3
  • Western Blot: Serpin A1/alpha 1-Antitrypsin Antibody [NBP1-90309] - Analysis using Anti-SERPINA1 antibody NBP1-90309 (A) shows similar pattern to independent antibody NBP1-90308 (B). (novusbio.com)
  • Western Blot: Serpin A1/alpha 1-Antitrypsin Antibody [NBP1-90309] - Analysis in human plasma. (novusbio.com)
  • Among them, we confirmed that kallistatin in both AAA and TAA patients and α-2-macroglobulin in TAA patients showed decrease levels in postsurgical sera similar to those in control sera by Western blot analysis with other sera from AAA and TAA patients. (biomedcentral.com)
Haptoglobin2
  • The LEGENDplex™ Human Acute Phase Panel 1 Mix and Match Beads are individual capture beads for 8 targets including α2-macroglobulin, α1-AGP, Haptoglobin, α1-antitrypsin, Ceruloplasmin, Fibrinogen, Prothrombin, and SAP. (biolegend.com)
  • The addition of physiologically relevant concentrations of the extracellular chaperones, clusterin, haptoglobin and alpha(2)-macroglobulin into CSF protected neuroblastoma cells from II1-422 toxicity and promoted II1-422 uptake in macrophage-like cells. (edu.au)
Trypsin3
  • 2. Determination of alpha 2-macroglobulin-trypsin complex with a new synthetic substrate. (nih.gov)
  • 5. Plasma alpha 2-macroglobulin-trypsin complexlike substance (MTLS) in pancreatic disease. (nih.gov)
  • 7. The two alpha 2-macroglobulin-bound trypsin molecules have different affinities for the basic pancreatic trypsin inhibitor. (nih.gov)
Protease inhibitor2
  • In fact, contrary to some belief, Apha 2-Macroglobulin is not a protease inhibitor per se. (healthynewage.com)
  • Alpha-2-Macroglobulin, more commonly referred to as A2M, is a master protease inhibitor that already exists in your blood and acts as a powerful inhibitor of cartilage breakdown. (boulderlongevity.com)
Substance1
  • Alpha 2 Macroglobulin (A2M) is a natural substance found in blood. (sdomg.com)
Inhibitor2
  • Identification of α2‐Macroglobulin as a Master Inhibitor of Cartilage‐Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis. (cellingbiosciences.com)
  • Injectable corticosteroids, which can be used to inhibit the creation of collagen, works as an inhibitor of DMH-1 alpha-2 macroglobulin. (sns-314.org)
Inhibitors1
  • Its enzyme inhibitors include Phosphoric acid diisopropyl ester fluoride (DFP), alpha-2-macroglobulin, and Nα-Tosyl-L-lysine chloromethyl ketone (TLCK). (marvelgent.com)
Proteases2
  • When taken on an empty stomach, oral proteases pass readily into the blood stream where they bind to Alpha 2-Macroglobulin. (healthynewage.com)
  • Some proteases when bound to Alpha 2-Macroglobulin maintain their catalytic activities, while other proteases do not. (healthynewage.com)
Interaction1
  • The interaction of vWF and GP1b alpha. (iiab.me)
Bound1
  • This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. (randrme.com)
Deletion1
  • On the lack of a clear-cut association between alpha-2-macroglobulin deletion and the risk of Alzheimer disease in Poland. (cdc.gov)
Neuronal1
  • Monoamine-activated alpha 2-macroglobulin (alpha 2M) has been shown to inhibit choline acetyltransferase in basal forebrain neurons as well as neurotrophin-dependent neuronal functions. (omeka.net)
Concentrations1
  • Intracranial infusion of monoamine-activated alpha 2-macroglobulin decreases dopamine concentrations within the rat caudate putamen. (omeka.net)
Cleavage2
  • Independent analysis of bait region cleavage dependent and thiolester bond cleavage dependent conformational changes by cross-linking of alpha 2-macroglobulin with cis-dichlorodiammineplatinum(II) and dithiobis(succinimidyl propionate). (duke.edu)
  • On the other hand, cross-linking of alpha 2M with DSP does prevent the conformational changes which trigger receptor recognition site exposure following cleavage of the alpha 2M thiolester bonds by CH3NH2. (duke.edu)
Tumor1
Interleukin2
Complex2
  • 11. Reaction of nerve growth factor gamma and 7S nerve growth factor complex with human and murine alpha 2-macroglobulin. (nih.gov)
  • The binding to alpha 2-macroglobulin "Hides" the exogenous protease from the immune system, yet allowing it to maintain its hydrolytic activity and act upon substrates small enough to come in contact with the protease/Alpha 2-Macroglobulin complex. (healthynewage.com)
Inhibitory2
  • A high molecular weight inhibitory fraction was identified as predominantly alpha-2 macroglobulin and a low molecular weight inhibitory fraction was identified as predominantly alpha-1 antiprotease. (ajtmh.org)
  • Alpha-2 macroglobulin was purified and alpha-1 antiprotease was partially purified from human sera by other methods and shown to have high inhibitory activity against the amebal cytotoxin. (ajtmh.org)
Inhibition1
  • Yu RJ, Grappel SF, Blank F. Inhibition of keratinases by alpha-2 macroglobulin. (msjonline.org)
Acute1
  • Acute, but not subchronic ozone increased α2-macroglobulin, adiponectin and osteopontin. (nih.gov)
Form1
  • The major form of PSA is believed to be enveloped by alpha-2 macroglobulin. (cdc.gov)
Patients1
  • 12. Degradation of a chromogenic substrate by alpha 2-macroglobulin from plasma of patients with rheumatoid arthritis. (nih.gov)
Fibronectin1
  • In addition, thrombospondin type 1, coagulation aspect 5/8, and fibronectin had been all down-regulated, but serpin and alpha 2-macroglobulin (A2M) had been up-regulated. (beloranib.net)
Electrophoresis1
  • Precipitation by electrophoresis is in the alpha region. (nih.gov)
Tissue2
  • Immunohistochemistry: Serpin A1/alpha 1-Antitrypsin Antibody [NBP1-90309] - Assessment of CCL18 and A1AT (Serpin A1/alpha 1-Antitrypsin) in bladder tissue. (novusbio.com)
  • Immunohistochemistry: Serpin A1/alpha 1-Antitrypsin Antibody [NBP1-90309] - Representative expression status for SERPINA1 level in benign tissue. (novusbio.com)
Growth2
  • Platelets have a lot of growth factors in them, but [they] also have something called alpha-2-macroglobulin," Dr. Davis explains to Bonnie Kate. (thedoctorstv.com)
  • transforming growth factor, alpha. (stanford.edu)
Include1
  • They include alpha 1-macroglobulins and alpha 2-macroglobulins. (nih.gov)
Products2
  • Once Alpha started actually using the right products for his face when he goes to bed at night, his skin started to look unbelievably different: the way it feels and he doesn't get breakouts anymore. (antiaginghelper.com)
  • IL-1 alpha/IL-1F1 " has 3 results in Products. (rndsystems.com)
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