Serum Globulins
Fusobacteria
Pregnancy-Associated alpha 2-Macroglobulins
Large (>160 kDa) glycoproteins with electrophoretic mobility of ALPHA-GLOBULINS, found in high concentration in the plasma of pregnant women but also in a number of species including mouse, rat, and others (ALPHA-MACROGLOBULINS). In humans, they are always present in the circulation and are nonspecific inhibitors of PROTEINASES, similar to COMPLEMENT PROTEINS (C3; C4; C5).
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Waldenstrom Macroglobulinemia
A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.
gamma-Globulins
Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Immunoglobulin M
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
alpha 1-Antitrypsin
Low Density Lipoprotein Receptor-Related Protein-1
Amino Acid Sequence
Antibodies
Antibody Specificity
Complement C3
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Complement C4
Complement C4a
Complement C3a
The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.
Complement C1q
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Complement C5a
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Amyloid
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Clusterin
Molecular Chaperones
Receptor, PAR-1
Receptor, PAR-2
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Inventions
Intellectual Property
Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)
Biotechnology
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Structural details of proteinase entrapment by human alpha2-macroglobulin emerge from three-dimensional reconstructions of Fab labeled native, half-transformed, and transformed molecules. (1/1037)
Three-dimensional electron microscopy reconstructions of native, half-transformed, and transformed alpha2-macroglobulins (alpha2Ms) labeled with a monoclonal Fab Fab offer new insight into the mechanism of its proteinase entrapment. Each alpha2M binds four Fabs, two at either end of its dimeric protomers approximately 145 A apart. In the native structure, the epitopes are near the base of its two chisel-like features, laterally separated by 120 A, whereas in the methylamine-transformed alpha2M, the epitopes are at the base of its four arms, laterally separated by 160 A. Upon thiol ester cleavage, the chisels on the native alpha2M appear to split with a separation and rotation to give the four arm-like extensions on transformed alpha2M. Thus, the receptor binding domains previously enclosed within the chisels are exposed. The labeled structures further indicate that the two protomeric strands that constitute the native and transformed molecules are related and reside one on each side of the major axes of these structures. The half-transformed structure shows that the two Fabs at one end of the molecule have an arrangement similar to those on the native alpha2M, whereas on its transformed end, they have rotated. The rotation is associated with a partial untwisting of the strands and an enlargement of the openings to the cavity. We propose that the enlarged openings permit the entrance of the proteinase. Then cleavage of the remaining bait domains by a second proteinase occurs with its entrance into the cavity. This is followed by a retwisting of the strands to encapsulate the proteinases and expose the receptor binding domains associated with the transformed alpha2M. (+info)Heme and acute inflammation role in vivo of heme in the hepatic expression of positive acute-phase reactants in rats. (2/1037)
Acute-phase protein synthesis in the liver during inflammation is regulated via cytokines and glucocorticoids. Using quantitative reverse transcription (RT)-PCR analysis and immunoassay, we explored, in the rat, the response of the acute-phase protein, alpha-2 macroglobulin (A2M), after systemic inflammation induced by lipopolysaccharide (LPS) or localized inflammation induced by turpentine oil (TO). The results indicate that synthesis of A2M is higher following TO-induced inflammation than LPS-induced inflammation and is not correlated with interleukin (IL)-6 or glucocorticoid levels. We studied the putative role of heme in this differential A2M expression following localized vs. systemic inflammation; addition of heme during LPS-induced inflammation can boost the expression of A2M, whereas blocking heme synthesis (by succinyl acetone) or enhancing its consumption in parallel biosynthetic pathways (cytochrome P450 induction by phenobarbital) decreases A2M expression. This decrease was abolished by exogenous heme supplementation. Finally, we demonstrate that heme supplementation is also able to increase the A2M response in female rats to a level similar to that in male rats providing a new insight into the puzzling sexual dimorphism observed previously during localized inflammation. We propose that heme should be considered a new regulatory element in controlling liver A2M expression during inflammation. (+info)Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity. (3/1037)
Legumain was recently discovered as a lysosomal endopeptidase in mammals [Chen, Dando, Rawlings, Brown, Young, Stevens, Hewitt, Watts and Barrett (1997) J. Biol. Chem. 272, 8090-8098], having been known previously only from plants and invertebrates. It has been shown to play a key role in processing of the C fragment of tetanus toxin for presentation by the MHC class-II system [Manoury, Hewitt, Morrice, Dando, Barrett and Watts (1998) Nature (London) 396, 695-699]. We examine here the specificity of the enzyme from pig kidney by use of protein, oligopeptide and synthetic arylamide substrates, all determinations being made at pH 5.8. In proteins, only about one in ten of the asparaginyl bonds were hydrolysed, and these were mostly predicted to be located at turns on the protein surface. Bonds that were not cleaved in tetanus toxin were cleaved when presented in oligopeptides, sometimes faster than an equivalent oligopeptide based on a bond that was cleaved in the protein. Legumain cleaved the bait region of rat alpha1-macroglobulin and was 'trapped' by the macroglobulin, as most other endopeptidases are, but did not interact with human alpha2-macroglobulin, which contains no asparagine residue in its bait region. Glycosylation of asparagine totally prevented hydrolysis by legumain. Specificity for arylamide substrates was evaluated with reference to benzyloxycarbonyl-Ala-Ala-Asn-aminomethylcoumarin, and the preference for the P3-position amino acid was Ala>Tyr(tertiary butyl)>Val>Pro>Phe=Tyr>Leu=Gly. There was no hydrolysis of substrate analogues containing mono- or di-N-methylasparagines, l-2-amino-3-ureidopropionic acid or citrulline in the P1 position. We conclude that mammalian legumain appears to be totally restricted to the hydrolysis of asparaginyl bonds in substrates of all kinds. There seem to be no strong preferences for particular amino acids in other subsites, and yet there are still unidentified factors that prevent hydrolysis of many asparaginyl bonds in proteins. (+info)Alpha2-macroglobulin and eosinophil cationic protein in the allergic airway mucosa in seasonal allergic rhinitis. (4/1037)
As previously demonstrated in seasonal allergic rhinitis, increased microvascular permeability and eosinophil activation are key features of allergic airway inflammation. In the present study, the hypothesis that exudation of alpha2-macroglobulin may cause the appearance of eosinophil cationic protein (ECP) in the airway lumen was explored. Nasal lavages were carried out using the nasal pool device before and during the pollen season both at baseline and after histamine challenge in 10 children with allergic rhinitis. Nasal lavage fluid levels of alpha2-macroglobulin and ECP were determined. All patients experienced nasal symptoms of allergic rhinitis during the pollen season (p<0.01-0.05). Baseline nasal lavage fluid levels of alpha2-macroglobulin and ECP were increased during the season (p<0.01-0.05) and were found to be well correlated (p<0.0001). Histamine produced concentration-dependent plasma exudation before and during the pollen season, but it was only during the pollen season that this caused an increase in the lavage fluid levels of ECP (p<0.05). These data suggest that exudation of plasma and increased tissue levels and output of eosinophil cationic protein characterize nasal mucosal inflammation in children with seasonal allergic rhinitis. The plasma exudation process in part may account for lumenal entry of eosinophil cationic protein molecules that have been released in mucosal tissue compartments. A combination of induced exudation and nasal lavage may improve the yield of important markers of inflammation in studies of nasal diseases. (+info)NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein. (5/1037)
The low density lipoprotein receptor-related protein is a member of the low density lipoprotein receptor family and contains clusters of cysteine-rich complement-like repeats of about 42 residues that are present in all members of this family of receptors. These clusters are thought to be the principal binding sites for protein ligands. We have expressed one complement-like repeat, CR8, from the cluster in lipoprotein receptor-related protein that binds certain proteinase inhibitor-proteinase complexes and used three-dimensional NMR on the 13C/15N-labeled protein to determine the structure in solution of the calcium-bound form. The structure is very similar in overall fold to repeat 5 from the low density lipoprotein receptor (LB5), with backbone root mean square deviation of 1.5 A. The calcium-binding site also appears to be homologous, with four carboxyl and two backbone carbonyl ligands. However, differences in primary structure are such that equivalent surfaces that might represent the binding interfaces are very different from one another, indicating that different domains will have very different ligand specificities. (+info)Abnormality in urinary protein excretion in Japanese men with impaired glucose tolerance. (6/1037)
OBJECTIVE: To examine whether subjects with impaired glucose tolerance (IGT) for more than 2 years have any abnormality in the kidney. RESEARCH DESIGN AND METHODS: We measured urinary excretion rate and clearance of various plasma proteins with different molecular radii and different isoelectric points in 22 Japanese men with IGT (IGT group) and 37 age-matched healthy control subjects (control group). RESULTS: Clearance of ceruloplasmin (molecular radius approximately 45 A; isoelectric point 4.4), IgG4 (molecular radius 55 A; isoelectric point 5.4), and IgG (molecular radius 55 A; isoelectric point 7.4) was significantly higher in the IGT group than in the control group, whereas there were no significant differences in urinary excretion rate of albumin (molecular radius 36 A; isoelectric points 4.8-5.2) and clearance of alpha 2-macroglobulin (molecular radius 88 A; isoelectric point 5.4) between the two groups. CONCLUSIONS: In the present study, we found that clearance of neutral-charged IgG, negatively charged IgG4, and ceruloplasmin with molecular radii of approximately 45-55 A was selectively increased in IGT subjects. This finding does not seem to be explained by impairment of charge and pore-size selectivity in the glomerulus. Therefore, considering the present result together with our recent finding that enhanced glomerular filtration rate (GFR) after acute protein loading in healthy subjects induced a selective increase in clearance of IgG, IgG4, and ceruloplasmin, we suggest that increased intraglomerular hydraulic pressure, although enhanced GFR was not demonstrated, may be at work in these mildly hyperglycemic subjects. (+info)Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin. (7/1037)
In the molecular interplay between pathogenic microorganisms and their host, proteolytic mechanisms are believed to play a crucial role. Here we find that the important human pathogen Streptococcus pyogenes (group A Streptococcus) expresses a surface protein with high affinity (Ka = 2.0 x 10(8) M-1) for alpha2-macroglobulin (alpha2M), the dominating proteinase inhibitor of human plasma. The immunoglobulin-binding protein G of group C and G streptococci also contains an alpha2M-binding domain and a gene encoding protein GRAB (protein G-related alpha2M-binding protein) was identified in the S. pyogenes Genome Sequencing data base. The grab gene is present in most S. pyogenes strains and is well conserved. Protein GRAB has typical features of a surface-attached protein of Gram-positive bacteria. It also contains a region homologous to parts of the alpha2M-binding domain of protein G and a variable number of a unique 28-amino acid-long repeat. Using Escherichia coli-produced protein GRAB and synthetic GRAB peptides, the alpha2M-binding region was mapped to the NH2-terminal part of protein GRAB, which is the region with homology to protein G. An isogenic S. pyogenes mutant lacking surface-associated protein GRAB showed no alpha2M binding activity and was attenuated in virulence when injected intraperitoneally in mice. Finally, alpha2M bound to the bacterial surface via protein GRAB was found to entrap and inhibit the activity of both S. pyogenes and host proteinases, thereby protecting important virulence determinants from proteolytic degradation. This regulation of proteolytic activity at the bacterial surface should affect the host-microbe relation during S. pyogenes infections. (+info)Destruction of articular cartilage by alpha 2 macroglobulin elastase complexes: role in rheumatoid arthritis. (8/1037)
OBJECTIVE: Neutrophil elastase accounts for the ability of some fresh rheumatoid synovial fluids to degrade cartilage matrix in vitro. The aim of this study was to determine if enzyme activity could result from depletion of synovial fluid inhibitors or protection of the enzyme from inhibition. METHODS: The ability of synovial fluids to inhibit porcine pancreatic elastase was investigated together with chemical pretreatments capable of inactivating alpha 1 protease inhibitor (alpha 1PI) or preventing formation of alpha 2 macroglobulin (alpha 2M) elastase complexes. Subsequently, complexes of human neutrophil elastase with alpha 2M were prepared and applied to frozen sections of cartilage. Proteoglycan loss was quantified by alcian blue staining and scanning and integrating microdensitometry. Parallel studies were carried out using a low molecular weight chromogenic elastase substrate. The effects of alpha 1PI and SF on these systems were investigated. Finally, synovial fluids were subjected to gel filtration and the fractions assayed for elastase activity. High molecular weight fractions were pooled, concentrated, and tested for their ability to degrade cartilage sections. RESULTS: All synovial fluids reduced the activity of porcine pancreatic elastase, the inhibition mainly being attributable to alpha 1PI, whereas remaining activity resulted from complexes of elastase with alpha 2M. Complexes of human neutrophil elastase with alpha 2M were shown to cause proteoglycan degradation in frozen sections of human articular cartilage. Alpha 1PI prevented alpha 2M elastase complexes from degrading cartilage but not the chromogenic substrate. The data suggested that alpha 1PI does not inhibit elastase bound to alpha 2M but sterically hinders the complex. However, only one of five synovial fluids was able to completely block the actions of alpha 2M elastase complexes against cartilage. Gel filtration of rheumatoid synovial fluids showed elastase and cartilage degrading activity to be associated with fractions that contained alpha 2M, and not with fractions expected to contain free enzyme. CONCLUSIONS: The data suggest that synovial fluid alpha 2M elastase complexes can degrade cartilage matrix in rheumatoid arthritis. (+info)
Ligand binding, conformational change and plasma elimination of human, mouse and rat α-macroglobulin proteinase inhibitors |...
alpha-Macroglobulins | Profiles RNS
Pregnancy zone protein
Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin...
Absence of an α2-Macroglobulin-Protease Complex in Cystic Fibrosis - Semantic Scholar
Alpha-2-macroglobulin-like protein 1
Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site | PNAS
Assay Solution. Human alpha 2-Macroglobulin ELISA Kit
SMART: A2M N 2 domain annotation
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious
disease using alpha(2)...
anti-alpha 2 Macroglobulin antibody [N2N3] | GeneTex
Fertility Pregnancy Calculator | The Pregnancy Zone
PREGNANCY ZONE - FertilityZone
PREGNANCY ZONE - FertilityZone
Effects of GMO Foods on Pregnant Woman | The Pregnancy Zone
AID 4853 - Compound was tested for its ability to displace [125I]GTI binding to 5-hydroxytryptamine 1D receptor recognition...
Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of...
Gentaur Molecular :Kamiya \ Rat Alpha 2 Macroglobulin ELISA \ KT-353
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017
Content - Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2018 |...
Natural Human alpha 2 Macroglobulin protein (ab91104)
WO2011133920A1 - Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
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BRIC Kit | MBL Life Sience -ASIA
Hyd ubiquitinates the NF-κB co-factor Akirin to activate an effective immune response in Drosophila
Mucosal vaccination against Foot & Mouth Disease using bacterial toxin by Sreerupa V Challa
US Patent Application for METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER AND INFECTIOUS DISEASE USING ALPHA(2)...
Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly |...
Lung bacteria feign pregnancy to avoid detection - Life Sciences Scotland
Studies on cell wall-attached proteins of <i>Streptococcus pyogenes</i>
ALZFORUM | NETWORKING FOR A CURE
Sequence Detail
A Receptor Mimic Neutralizing Mechanism Against Hepatitis A Virus Infection Identified by IBP and STRUBI Scientists---...
Gentaur Molecular :Accu \ Alpha 2 Macroglobulin, Goat anti Human, Rabbit, Bovine, Swine, Dog, Cat \ ACL20010AP
OpenWrt Project: Cisco ON-100 k9 v01/ v02
Words ending in M (page 2)
Fórum / Old Punx fest 2012
Fórum / Old Punx fest 2012
Quick integral question | Physics Forums - The Fusion of Science and Community
Plus it
Criteria for the specific measurement of plasmin inhibitor activity using an enzymatic procedure - IFCC
The hemopexin and O-glycosylated domains tune gelatinase B/MMP-9 bioavailability via inhibition and binding to cargo receptors ...
OriGene - LRP5 (NM 002335) Human ORF cDNA Clone
Macroglobulin, Ask a Doctor about Macroglobulin - Doctors insight on HealthcareMagic
Toxins | Free Full-Text | Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands...
Fibrinogen γ-chain dodecapeptide - CCP1202-5mg | acris-antibodies.com
A Metabolomic Approach (1H HRMAS NMR Spectroscopy) Supported by Histology to Study Early Post-transplantation Responses in...
Panza dIschia Hotels with Meeting Facilities- Meeting Hotels in Panza dIschia- Corporate Meeting Planning: Meetings and...
Bioline International Official Site (site up-dated regularly)
alpha2-M (alpha2-Macroglobulin)
diglloyd blog: Grab em While You Can: Leica 28/2 Summicron, 35/2 Summicron, 50/1.4 Summilux
Jaimi (25) - Looking in Rosanna, Ivanhoe East, Ivanh...
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CyFlow™ CD11b FITC | Expanded Antibody Search | Reagents | Sysmex Flow Cytometry Canada
SDS-PAGE
... for proteinuria evaluates the levels of various serum proteins in the urine, e.g. Albumin, Alpha-2-macroglobulin and ...
Interstitial collagenase
Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue This enzyme belongs to the ... Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins". The Journal of Biological Chemistry ... Sottrup-Jensen L, Birkedal-Hansen H (January 1989). "Human fibroblast collagenase-alpha-macroglobulin interactions. ...
A2ML1
Alpha-2-macroglobulin-like 1 abbreviated as α2ML1 is a protein that in humans is encoded by the A2ML1 gene. α2ML1 is a large, ... "Entrez Gene: Alpha-2-macroglobulin-like 1". Galliano MF, Toulza E, Gallinaro H, Jonca N, Ishida-Yamamoto A, Serre G, Guerrin M ... This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several ... "The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies ...
Fibrinolysis
Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin. Plasmin activity is also reduced by thrombin-activatable ... Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ... Nevertheless, excess levels of PAI and alpha 2-antiplasmin have been implicated in the metabolic syndrome and various other ... alpha 2-antiplasmin, and plasminogen) from plasma and then observing the time required for clot dissolution. A shortened lysis ...
LDL-receptor-related protein-associated protein
It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density ... Jou YS, Goold RD, Myers RM (Nov 1994). "Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) ... coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the ... "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen". The ...
Acute-phase protein
Alpha 2-macroglobulin and coagulation factors affect coagulation, mainly stimulating it. This pro-coagulant effect may limit ... December 1993). "Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in ...
Developmental Haemostasis
alpha-2-Macroglobulin (A2M): is also a major inhibitor of thrombin. It is present in 2-3 fold higher concentration during ... the functional role of alpha-2-macroglobulin and influence of Developmental Haemostasis. British Journal of Haematology, 138(3 ...
Interleukin-6 receptor
"Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin". Biol. Chem. Hoppe-Seyler. 373 (7): ... Kluck PM, Wiegant J, Jansen RP, Bolk MW, Raap AK, Willemze R, Landegent JE (1993). "The human interleukin-6 receptor alpha ... The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528-35. doi:10.1074/jbc. ...
Low-density lipoprotein receptor-related protein 8
ApoER2 splice variants can act as a receptor for alpha-2-macroglobulin which can have a role in clearance of alpha-2- ... which is controlled by proteolytic inhibitors such as alpha-2-macroglobulin. Studies have shown that a high presence of alpha-2 ... Isolation of cDNA encoding proteins associated with Aβ was used to discover alpha-2-macroglobulin. These discoveries may link ... alpha-2-macroglobulin and its receptors, one of them being ApoER2, to Alzheimer's disease. ApoER2 interaction with reelin and ...
George Stouffer
Stouffer, G. A.; LaMarre, J.; Gonias, S. L.; Owens, G. K. (August 25, 1993). "Activated alpha 2-macroglobulin and transforming ... Stouffer attended the University of Maryland School of Medicine and was inducted into the Alpha Omega Alpha honor society. He ...
Glucocorticoid receptor
... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes Dev. 17 (20): 2564-77. doi:10.1101/ ... The role of alpha and beta isoforms of the glucocorticoid receptor]". Arch. Bronconeumol. 38 (9): 436-40. doi:10.1016/S0300- ...
STAT3
... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes & Development. 17 (20): 2564-77. ... Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y (May 2003). "Opposing effects of PML and PML/RAR alpha ... "Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin". ...
Nephrotic syndrome
... such as alpha-2 macroglobulin and lipoproteins. An increase in the latter can cause the hyperlipidemia associated with this ...
LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein ... "The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine ... The extracellular domain of LRP1 is the alpha-chain, which comprises four ligand-binding domains (numbered I-IV) containing two ... LRP1 has been shown to interact with: A2-Macroglobulin, β-amyloid precursor protein, APBB1, APOE, Aprotinin, C1S/C1q inhibitor ...
Lipoprotein lipase
"The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine ... domain of lipoprotein lipase binds to the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor (LRP ...
KLK7
... elafin and alpha-2-Macroglobulin-like 1. Both Zn2+ and Cu2+ ions are also able to inhibit KLK7. KLK7 is a chymotrypsin-like ... "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis". J Biol Chem. 281 (9): 5780- ...
CD109
2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing ... 2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family". Gene. 327 (2): 171-83. doi:10.1016 ...
POTEB
... and alpha-2-macroglobulin. This data is based on affinity capture- mass spectrometry. POTEB expression is low or completely ... However, there is unpublished data suggesting an interaction between POTEB and alpha-1-B glycoproteins, APOBEC1 complementation ...
Disease-modifying osteoarthritis drug
"Reduction of Pro-Inflammatory Synovial Fluid Biomarkers in Osteoarthritis of the Knee With Alpha-2 Macroglobulin - Full Text ... "Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis ...
Pancreatic elastase
Alpha 1-antitrypsin and alpha-2-macroglobulin are human serum protease inhibitors that completely inhibit the general ...
Hep G2
... alpha 2-macroglobulin, alpha 1-antitrypsin, transferrin and plasminogen.[citation needed] They have been grown successfully in ...
List of MeSH codes (D12.776)
... alpha 1-antichymotrypsin MeSH D12.776.377.715.085.085 - alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins ... alpha-macroglobulins See List of MeSH codes (D12.776.395). MeSH D12.776.402.150.100.200 - chimerin 1 MeSH D12.776.402.150. ... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ...
List of MeSH codes (D12.776.124)
... alpha-macroglobulins MeSH D12.776.124.790.720.100.500 - pregnancy-associated alpha 2-macroglobulins The list continues at List ... alpha 1-antichymotrypsin MeSH D12.776.124.790.106.085 - alpha 1-antitrypsin MeSH D12.776.124.790.106.100 - alpha-macroglobulins ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 - immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 - ... immunoglobulin alpha-chains MeSH D12.776.124.790.651.114.619.251 - immunoglobulin d MeSH D12.776.124.790.651.114.619.251.500 - ...
Tissue plasminogen activator
... inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin ... Tissue plasminogen activator has been shown to interact with: Fibrinogen alpha chain LRP1 SERPINI1 tPA and plasmin are the key ... alpha C-domains". Biochemistry. 40 (3): 801-8. doi:10.1021/bi001789t. PMID 11170397. Ichinose A, Takio K, Fujikawa K (July 1986 ...
Cryofibrinogenemia
... alpha-1 antitrypsin and alpha-2-macroglobulin, which inhibit the naturally occurring fibrinolytic agent, plasmin. 2) The blood ...
Whale barnacle
... so it may be that whale barnacles use the alpha-2-macroglobulin, a plasma protein of the blood common in vertebrates. After ...
FibroTest
Alpha-2-macroglobulin, Haptoglobin, Apolipoprotein A1, Gamma-glutamyl transpeptidase (GGT), Total bilirubin, and Alanine ... FibroSure uses quantitative results of five serum biochemical markers, α2-macroglobulin, haptoglobin, apolipoprotein A1, ...
Protease inhibitor (biology)
... alpha-2-Macroglobulin Pefabloc SC Pepstatin PMSF (phenylmethanesulfonyl fluoride) TLCK Trypsin inhibitors Kunitz domain ... The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ... In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this ...
Rheopheresis
... alpha-2-macroglobulin, von Willebrand factor, LDL cholesterol and immunoglobulin M. It is an experimental treatment for dry age ...
Pregnancy zone protein
... alpha-2-macroglobulin like, Xh-antigen, Schwangerschaftsprotein-3, Pα-1, pregnancy-associated α-macroglobulin, pregnancy- ... PZP is part of the alpha-2 globulin family of proteins. It is often associated with pregnancy, during which it can be the most ...
Category:Blood proteins
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Transferrin
Alpha 1-antichymotrypsin. *Alpha 1-antitrypsin. *Alpha 2-macroglobulin. *C-reactive protein ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ...
Gel electrophoresis of proteins
α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ... The globulins are classified by their banding pattern (with their main representatives): The alpha (α) band consists of two ...
Antibody
alpha-2 (Ceruloplasmin). *Retinol binding protein. other:. *alpha-1 (Orosomucoid). *alpha-2 (alpha-2-Macroglobulin, Haptoglobin ... Feldmann M, Maini R (2001). "Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?". Annu Rev Immunol. 19 (1): ... Possible classes of heavy chains in antibodies include alpha, gamma, delta, epsilon, and mu, and they define the antibody's ... Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain ...
Integrin beta 3
platelet alpha granule membrane. • integrin alphav-beta3 complex. • extracellular exosome. • lamellipodium membrane. • cell ... Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing". Thromb. Haemost. 87 (2): 187-93. doi: ... The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha ... Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as ...
Affinity chromatography
Lectins, such as concanavalin A are proteins which can bind specific alpha-D-mannose and alpha-D-glucose carbohydrate molecules ... Of many uses of affinity chromatography, one use of it is seen in affinity purification of albumin and macroglobulin ... This type of purification is helpful in removing excess albumin and α2-macroglobulin contamination, when performing mass ...
Plasminogen activator inhibitor-2
Like other serpins, PAI-2 has three beta sheets (A, B, C) and nine alpha helices (hA-hI).[6][7] The structure of PAI-2 mutants ... gene are associated with basal and tumor necrosis factor-alpha-induced transcription in monocytes". European Journal of ... "Plasminogen activator inhibitor type 2 inhibits tumor necrosis factor alpha-induced apoptosis. Evidence for an alternate ...
Albumin
alpha-2 (Ceruloplasmin). *Retinol binding protein. other:. *alpha-1 (Orosomucoid). *alpha-2 (alpha-2-Macroglobulin, Haptoglobin ... Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin ... A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein, vitamin D-binding ... alpha-fetoprotein, and vitamin D-binding protein gene family". The Journal of Biological Chemistry. 269 (27): 18149-54. PMID ...
Lactalbumin
alpha-2 (Ceruloplasmin). *Retinol binding protein. other:. *alpha-1 (Orosomucoid). *alpha-2 (alpha-2-Macroglobulin, Haptoglobin ... There are alpha and beta lactalbumins; both are contained in milk.. Scientific studies suggest that certain types of ... alpha-1 (Alpha 1-antichymotrypsin, Alpha 1-antitrypsin). *alpha-2 (Alpha 2-antiplasmin) ...
Albumin
alpha-2 (Ceruloplasmin). *Retinol binding protein. other:. *alpha-1 (Orosomucoid). *alpha-2 (alpha-2-Macroglobulin, Haptoglobin ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin ... A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein, vitamin D-binding ...
File:Ideogram house mouse chromosome 6.svg
Alpha-2-Macroglobulin. *Alpha-synuclein. *Amylin. *Aquaporin 1. *Arachidonate 5-lipoxygenase. *Atrophin 1 ...
Serum protein electrophoresis
Alpha-2 zone[edit]. This zone consists principally of alpha-2 macroglobulin (AMG or A2M) and haptoglobin. There are typically ... Alpha-2 macroglobulin may be elevated in children and the elderly. This is seen as a sharp front to the alpha-2 band. AMG is ... Alpha-1 - alpha-2 interzone[edit]. Two faint bands may be seen representing alpha 1-antichymotrypsin and vitamin D binding ... Stevenson, FT; Greene, S; Kaysen, GA (January 1998). "Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are ...
抗體 - 維基百科,自由的百科全書
巨球蛋白(英語:Macroglobulin)/微球蛋白(英語:Microglobulin) ... Feldmann M, Maini R. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Annu Rev Immunol. 2001, 19 (1): 163 ... Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. ... α1胰凝乳蛋白酶抑制劑(英語:Alpha
Orosomucoid
Alpha 1-antichymotrypsin. *Alpha 1-antitrypsin. *Alpha 2-macroglobulin. *C-reactive protein ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... Orosomucoid (ORM) or alpha-1-acid glycoprotein (α1AGp,[1] AGP or AAG) is an acute phase (acute phase protein) plasma alpha- ... Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five- ...
Tissue factor
Endothelial cells do not express TF except when they are exposed to inflammatory molecules such as tumor necrosis factor-alpha ... TNF-alpha). Another cell type that expresses TF on the cell surface in inflammatory conditions is the monocyte (a white blood ...
Platelet
α granules (alpha granules) - containing P-selectin, platelet factor 4, transforming growth factor-β1, platelet-derived growth ... Platelets store vWF in their alpha granules. When the endothelial layer is disrupted, collagen and VWF anchor platelets to the ... Alpha granules contain clotting mediators such as factor V, factor VIII, fibrinogen, fibronectin, platelet-derived growth ... Platelets contain dense granules, lambda granules and alpha granules. Activated platelets secrete the contents of these ...
Fibrin
Alpha 1-antichymotrypsin. *Alpha 1-antitrypsin. *Alpha 2-macroglobulin. *C-reactive protein ... The chemical structures of the ligands are Ca2+ ion, alpha-D-mannose (C6H12O6), and D-glucosamine (C6H13NO5). ... The structure is mainly made up of single alpha helices shown in red and beta sheets shown in yellow. The two blue structures ...
Placental alpha microglobulin-1 (PAMG-1)
Placental alpha macroglobulin-1 (PAMG-1) has been the subject of over 20 clinical investigations, the majority of which have ... Placental alpha microglobulin-1 (PAMG-1) is a human protein that was first isolated in 1975 from amniotic fluid. PAMG-1 is an ... Lee, S. E.; Park, J. S.; Norwitz, E. R.; Kim, K. W.; Park, H. S.; Jun, J. K. (2007). "Measurement of placental alpha- ... PAMG-1 was originally referred to as specific alpha-1 globulin of placenta. PAMG-1 is present in blood and the amniotic fluid ...
Index of biochemistry articles
... alpha-beta T-cell antigen receptor - alpha-fetoprotein - alpha-globulin - alpha-macroglobulin - alpha-MSH - Ames test - amide ... alpha adrenergic receptor - Alpha helix - alpha-1 adrenergic receptor - alpha-2 adrenergic receptor - ... transforming growth factor alpha - transforming growth factor beta - transforming growth factor beta receptor - transient ... interferon-alpha - interferon-beta - interleukin receptor - interleukin-1 receptor - interleukin-2 receptor - interleukin-3 - ...
Pharmacology of bicalutamide
5 alpha-dihydrotestosterone and [3H]cortisol binding to plasma proteins". J. Steroid Biochem. 33 (2): 251-5. doi:10.1016/0022- ... and as a ligand and inhibitor of α2-macroglobulin. The pharmacokinetics of bicalutamide are unaffected by food, age, body ... role of 3 alpha- and 3 beta-androstanediols". Biology of Reproduction. 51 (3): 562-71. doi:10.1095/biolreprod51.3.562. PMID ...
Alpha globulin
... amyloid A Alpha 1-lipoprotein Haptoglobin Alpha-2u globulin α2-macroglobulin Ceruloplasmin Thyroxine-binding globulin Alpha 2- ... The alpha globulins typically have molecular weights of around 93 kDa. α1-antitrypsin Alpha 1-antichymotrypsin Orosomucoid ( ... antiplasmin Protein C Alpha 2-lipoprotein Angiotensinogen Cortisol binding globulin Vitamin D-binding protein Alpha-Globulins ... Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions ...
Alpha-2-Macroglobulin - Wikipedia
The loss of alpha-2-macroglobulin into urine is prevented by its large size. The net result is that alpha-2-macroglobulin ... 10-15% of copper in human plasma is chelated by alpha-2-macroglobulin. alpha-2-Macroglobulin levels are increased when the ... of alpha-2-macroglobulin leads to increased risk of Alzheimers disease. alpha-2-Macroglobulin binds to and removes the active ... alpha-2-macroglobulin is retained in the bloodstream. Increased production of all proteins means alpha-2-macroglobulin ...
Alpha-2-Macroglobulin
Upregulation of Alpha-2-Macroglobulin in Replicative Senescence | SpringerLink
Ma H, Li RZ, Zhang ZY, Tong TJ (2004) mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture ... Alpha-2-macroglobulin (α2Μ) Electrophoretic mobility shift assays (EMSA) Functional promoter region determination α2M ... Ma L.W., Li G.D., Tong T.J. (2014) Upregulation of Alpha-2-Macroglobulin in Replicative Senescence. In: Hayat M. (eds) Tumor ... Lin VK, Wang SY, Boetticher NC, Vazquez DV, Saboorian H, McConnell JD, Roehrborn CG (2005) Alpha(2) macroglobulin, a PSA ...
Alpha-2-macroglobulin, thiol-ester bond-forming (IPR019565) | InterPro | EMBL-EBI
A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor.. Biochemistry ... Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3.. J. Biol. Chem. 264 11428-35 ... The alpha-macroglobulin (aM) family of proteins includes protease inhibitors [PMID: 2473064], typified by the human tetrameric ... Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation.. J. Biol. Chem. 264 11539-42 1989 ...
Molecular cloning of Limulus alpha 2-macroglobulin
alpha 2M from Limulus shows many of the typical characteristics of mammalian alpha 2M, including the presence of an internal ... alpha 2M) in the hemolymph plasma and hemocytes. ... The American horseshoe crab Limulus polyphemus contains alpha 2 ... Trypsin-treated Limulus alpha 2M, but not the native alpha 2M, displaced methylamine-treated human 125I-alpha 2M from the human ... The American horseshoe crab Limulus polyphemus contains alpha 2-macroglobulin (alpha 2M) in the hemolymph plasma and hemocytes ...
TNO Repository search for: subject:'alpha-Macroglobulins'
alpha 2 macroglobulin · biological marker · gelatinase A · gelatinase B · hydroxyproline · interstitial collagenase · matrix ... Biomedical Research · alpha 2 macroglobulin · interstitial collagenase · matrix metalloproteinase · prointerstitial collagenase ... Chemicals / CAS: alpha 2 macroglobulin, 95568-41-5; gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; hydroxyproline, 51-35 ... A2-antiplasmin · Activity assay · Automated · Plasmin inhibitor · Adult · alpha-Macroglobulins · Antifibrinolytic Agents · ...
Natural Human alpha 2 Macroglobulin protein (ab91104)
Buy our Natural Human alpha 2 Macroglobulin protein. Ab91104 is a full length protein produced in Nativesyntheticaly and has ... Lane 4. 5 µg alpha 2 Macroglobulin (reduced/ heated) Lane 5. 10 µg alpha 2 Macroglobulin (reduced/ heated) Lane 6. 20 µg alpha ... 5 µg alpha 2 Macroglobulin (non-reduced/no heat) Lane 2. 10 µg alpha 2 Macroglobulin (non-reduced/no heat) Lane 3. 20 µg alpha ... Natural Human alpha 2 Macroglobulin protein. See all alpha 2 Macroglobulin proteins and peptides. ...
Anti-alpha 2 Macroglobulin antibody (HRP) (ab7339) Protocols
alpha 2-Macroglobulin Lysates: Novus Biologicals
Browse our alpha 2-Macroglobulin Lysate catalog backed by our Guarantee+. ... alpha 2-Macroglobulin lysate, A2M lysate, ALPL lysate, alpha-2-M lysate, alpha-2-macroglobulin lysate, C3 and PZP-like alpha-2- ... alpha 2-Macroglobulin Lysates. We offer alpha 2-Macroglobulin Lysates for use in common research applications: Western Blot. ... Our alpha 2-Macroglobulin Lysates can be used in a variety of model species: Human. Use the list below to choose the alpha 2- ...
alpha 2-Macroglobulin Proteins: Novus Biologicals
Browse our alpha 2-Macroglobulin Protein catalog backed by our Guarantee+. ... alpha 2-Macroglobulin Proteins. We offer alpha 2-Macroglobulin Peptides and alpha 2-Macroglobulin Proteins for use in common ... alpha 2-Macroglobulin protein, A2M protein, ALPL protein, alpha-2-M protein, alpha-2-macroglobulin protein, C3 and PZP-like ... Our alpha 2-Macroglobulin Peptides and alpha 2-Macroglobulin Proteins can be used in a variety of model species: Human. Use the ...
BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells | PNAS
Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: Presence of the alpha 2-macroglobulin ... 1992) Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J 6(15):3345-3353. ... 2006) Lack of site-specific production of decidual alpha-2 macroglobulin in human pregnancy. J Soc Gynecol Investig 13(7):491- ... 1994) Expression of the alpha 2-macroglobulin-encoding gene in rat brain and cultured astrocytes. Gene 141(2):155-162. ...
Alpha 2-macroglobulin | definition of Alpha 2-macroglobulin by Medical dictionary
What is Alpha 2-macroglobulin? Meaning of Alpha 2-macroglobulin medical term. What does Alpha 2-macroglobulin mean? ... Looking for online definition of Alpha 2-macroglobulin in the Medical Dictionary? Alpha 2-macroglobulin explanation free. ... alpha-2 macroglobulin. (redirected from Alpha 2-macroglobulin). Also found in: Wikipedia. alpha-2 macroglobulin. Plasma ... Structure of the human alpha 2-macroglobulin gene and its promoter.. Alpha 2 macroglobulin activity in rats infected with ...
Alpha 2-macroglobulin is the major neutralizing inhibitor of influenza A virus in pig serum
Although alpha 2-macroglobulin has been identified as the inhibitor in horse serum, the inhibitors in pig and rabbit sera have ... The inhibitor corresponded in size to alpha 2-macroglobulin and cross-reacted antigenically with human alpha 2-macroglobulin. ... Alpha 2-macroglobulin is the major neutralizing inhibitor of influenza A virus in pig serum Virology. 1993 Apr;193(2):974-6. ... 6-galactose but not N-acetylneuraminic acid-alpha 2,3-galactose. These data indicate that alpha 2-macroglobulin is the major ...
Prostate-specific antigen forms complexes with human alpha 2-macroglobulin and binds to the alpha 2-macroglobulin receptor/LDL...
To investigate the binding of the prostate-specific antigen (PSA) to human alpha 2-macroglobulin (alpha 2-M) and to alpha 1- ... Prostate-specific antigen forms complexes with human alpha 2-macroglobulin and binds to the alpha 2-macroglobulin receptor/LDL ... Complexes of PSA-alpha 2-M and PSA-ACT were found to bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein ( ... Kinetic analysis revealed faster binding of PSA to alpha 2-M than to ACT. The PSA bound to alpha 2-M is caged by the inhibitor ...
Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma. - PubMed - NCBI
Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma.. Thieme R1, Kurz S1 ... Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma ... Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma ... Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma ...
RCSB PDB - 4ZIU: Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7...
Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7 to the C-terminus ... Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7 to the C-terminus ... Structural and functional insights into Escherichia coli alpha 2-macroglobulin endopeptidase snap-trap inhibition.. Garcia- ... Gram-negative bacteria from the human gut microbiome encode a relative of the human endopeptidase inhibitor, α2-macroglobulin ( ...
A Role for Alpha-2-Macroglobulin in the Cancer Immunity of Naked Mole-Rats - Fight Aging!
anti-alpha 2 Macroglobulin antibody [N2N3] | GeneTex
... alpha-2-macroglobulin) for WB. Anti-alpha 2 Macroglobulin pAb (GTX112856) is tested in Human samples. 100% Ab-Assurance. ... alpha-2-macroglobulin antibody, alpha-2-M antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody ... alpha-2-macroglobulin. Background. Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many ... Storage Conditions: alpha 2 Macroglobulin antibody [N2N3]. Storage Buffer. 1XPBS, 1% BSA, 20% Glycerol (pH7). 0.01% Thimerosal ...
Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017
... Download the ... 12, 2017 /PRNewswire/ -- Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline ... Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Pipeline Review, H2 2017. Friday, ... It also reviews key players involved in Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5 ...
alpha-Macroglobulins | Semantic Scholar
Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These ... alpha-Macroglobulins. Known as: alpha Macrofetoproteins, alpha macroglobulin, Alpha macroglobulins Expand. Glycoproteins with a ... Rat alpha 1-macroglobulin (alpha 1M), rat alpha 2-macroglobulin (alpha 2M) migrated as single bands on non-denaturing gels when ... Human alpha 2-macroglobulin (H alpha 2M) is a major IL-1 beta binding plasma protein. The characteristics of the H alpha 2M IL- ...
Alpha-2 Macroglobulin (A2M), anti-Human Po | LeeBio.com
Buy goat anti-human Alpha 2-Macroglobulin polyclonal antibody for research, development and IVD manufacturing uses - Inquire ... Polyclonal anti-human alpha 2 macroglobulin (a2M) procedure goats were immunized with highly purified human alpha 2- ... macroglobulin isolated from human serum. The resulting anti-human alpha-2 Macroglobulin (a2M) was solid phase absorbed then ... This anti-human alpha 2-macroglobulin (A2M) is suitable for depletion, ELISA and Blotting applications. ...
Inhibition of Entamoeba Histolytica Cytotoxin by Alpha 1 Antiprotease and Alpha 2 Macroglobulin* | The American Journal of...
Alpha-2 macroglobulin was purified and alpha-1 antiprotease was partially purified from human sera by other methods and shown ... A high molecular weight inhibitory fraction was identified as predominantly alpha-2 macroglobulin and a low molecular weight ... Preparative isoelectric focusing of human serum isolated inhibitory fractions containing these same alpha globulins. ... inhibitory fraction was identified as predominantly alpha-1 antiprotease. ...
Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive protein production | SpringerLink
Alpha-2-macroglobulin (α2-M), a serum protease inhibitor that also binds cytokines, neutralized the inhibitory effect exerted ... Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive protein production. *Andrew W. Taylor1. & ... Alpha-2-macroglobulin (α2-M), a serum protease inhibitor that also binds cytokines, neutralized the inhibitory effect exerted ... Taylor, A.W., Mortensen, R.F. Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive protein production. ...
"Protease-activated alpha-2-macroglobulin can inhibit amyloid formation" by Amy R. Wyatt, Patrick Constantinescu et al.
"α2-Macroglobulin (α2M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of ... Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms ... Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms. FEBS Letters, 587 (5), 398- ... α2-Macroglobulin (α2M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of ...
Alpha-2-macroglobulin Antibody 13545-1-AP | Proteintech
Alpha-2-macroglobulin Antibody 13545-1-AP has been identified with IF, IHC, IP, WB, ELISA. 13545-1-AP detected 185 kDa band in ... alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and ... A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, FWP007, S863 7, α-2M ... Alpha-2-macroglobulin Antibody 0 Publications. Rabbit Polyclonal, Catalog number: 13545-1-AP ...
"Alpha-2-macroglobulin is acutely sensitive to freezing and lyophilizat" by Amy R. Wyatt, Janet R. Kumita et al.
... and are also influenced by dissociation of the native alpha-2-macroglobulin tetramer into stable dimers. Alpha-2-macroglobulin ... The activities of alpha-2-macroglobulin are typically dependent on whether its conformation is native or transformed (i.e. ... We show that sucrose (but not glycine) effectively protects native alpha-2-macroglobulin from denaturation during freezing and/ ... These conformational changes in alpha-2-macroglobulin are not always detected by standard native polyacrylamide gel ...
Get PDF - Interactions of pregnancy associated plasma protein a and alpha 2 macro globulin on metal chelate affinity...
Interactions of pregnancy associated plasma protein a and alpha 2 macro globulin on metal chelate affinity chromatography ... Evolution of alpha 2 macro globulin the structure of a protein homologous with human alpha 2 macro globulin from plaice ... Studies on alpha 2 macro globulin in bovine plasma part 2 interaction of alpha 2 macro globulin and trypsin. Journal of ... Evolution of alpha 2 macro globulin the purification and characterization of a protein homologous with human alpha 2 macro ...
US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious
disease using alpha(2)...
... macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes ... The present invention relates to the use of alpha (2) ... The Alpha (2) Macroglobulin Receptor, or "CD91" The alpha (2) ... macroglobulin-binding molecule is an antibody specific to alpha (2) macroglobulin. The alpha (2) macroglobulin-specific ... Alpha (2) Macroglobulin The .alpha.-macroglobulins are members of a protein superfamily of structurally related proteins which ...
Anti-A2M / Alpha-2-Macroglobulin Antibody (clone SPM178) for WB/Western, ELISA LS-C189385
... that binds human alpha-2-macroglobulin (also known as A2M). Validated for ELISA and western blot. ... Alpha-2-macroglobulin antibody LS-C189385 is a purified mouse monoclonal (clone SPM178, isotype IgG1, kappa) ... Anti-A2M / Alpha-2-Macroglobulin Antibody (HRP) LS-C25313 Antibody:. Goat Polyclonal (IgG) to Human A2M / Alpha-2-Macroglobulin ... Anti-A2M / Alpha-2-Macroglobulin Antibody (C-Terminus) LS-C46958 Antibody:. Rabbit Polyclonal to Human A2M / Alpha-2- ...
Rat Alpha-2 Macroglobulin (A2M) - Innovative Research
Alpha-2 macroglobulin (A2M) is a large plasma protein found in the blood. A2M is produced by the liver, and is a major ... component of the alpha-2 band in protein elec ... Rat Alpha-2 Macroglobulin, Alpha-2 macroglobulin (A2M) is a ... studies showed that the comparison of the amino acid compositions of Alpha-2 macroglobulin from Rat and Alpha-2 macroglobulin ... It was reported that the conformation of rat acute-phase Alpha-2 macroglobulin , both at the molecular and secondary structural ...
AntibodyProteinAntibodiesAlpha2-macroglobulinComplexesReceptorNative alpha-2-macroglobulReactivityGeneProteins and peptidesInhibitsInhibitorSequenceProteinase inhibitorsGlycoproteinThiol-esterMammalianInhibitSepsisELISA KitPlasmaCharacterizationInhibitorsSwineAmino AcidReceptorsWestern BlotSerum albuminAssayCartilageAlzheimer'sDegenerationPeptides1989AffinityThioredoxinAmyloidDeficiencyMolecular weightIMSEARBait regionConformationGlycoproteins
Antibody8
- Human tissue extract (30 μg) was separated by 5% SDS-PAGE, and the membrane was blotted with alpha 2 Macroglobulin antibody [N2N3] (GTX112856) diluted at 1:10000. (genetex.com)
- This HRP-conjugated antibody forms a complex with the previously bound alpha 2-macroglobulin. (antibody-antibodies.com)
- Inquiry About anti-Alpha-2-macroglobulin antibody If you hope to order it or contact us directly, please contact us via [email protected] (biobool.com)
- Further information about each individual A2M - Alpha 2 Macroglobulin Antibody is available by following the associated links. (affinitybiologicals.com)
- We have developed a quantitative sandwich enzyme-linked immunosorbent assay (ELISA) for the alpha 2-macroglobulin-kallikrein (alpha 2M-Kal) complex using an F(ab')2 derivative of a monospecific polyclonal antibody against alpha 2 M as the capture antibody and a unique murine monoclonal antibody, 13G11, against the heavy chain of kallikrein as the detector antibody. (chaen-rcah.ca)
- Use of anti-idiotypic antibodies to establish that monoclonal antibody 7H11D6 binds to the alpha 2-macroglobulin receptor recognition site. (duke.edu)
- Studies were performed to determine if monoclonal antibody 7H11D6 binds to the region of alpha 2-macroglobulin (alpha 2M) that interacts with cell-surface receptors. (duke.edu)
- F(ab')2 fragments prepared from this antibody delayed the in vivo clearance of alpha 2M-trypsin complexes from the murine circulation and blocked the in vitro binding of 125I-labeled alpha 2M-trypsin to rat kidney fibroblasts. (duke.edu)
Protein49
- alpha-2-Macroglobulin (α2M) is a large (720 KDa) plasma protein found in the blood. (wikipedia.org)
- Alpha-2-macroglobulin may act as a carrier protein because it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β. (wikipedia.org)
- Overall, alpha-2-Macroglobulin is the largest major nonimmunoglobulin protein in human plasma. (wikipedia.org)
- The amino acid sequence of alpha-2-macroglobulin has been shown to be 71% the same as that of the Pregnancy zone protein. (wikipedia.org)
- a sequence of amino acids in an α2-macroglobulin molecule, or a homologous protein, that contains scissile peptide bonds for those proteinases that it inhibits) and a thiol ester, (iii) a similar protease inhibitory mechanism and (iv) the inactivation of the inhibitory capacity by reaction of the thiol ester with small primary amines. (wikipedia.org)
- Human pregnancy zone protein and alpha 2-macroglobulin. (ebi.ac.uk)
- We offer alpha 2-Macroglobulin Peptides and alpha 2-Macroglobulin Proteins for use in common research applications: Blocking/Neutralizing, Control, ELISA, Protein Array, SDS-Page, Western Blot. (novusbio.com)
- Each alpha 2-Macroglobulin Peptide and alpha 2-Macroglobulin Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
- We demonstrate that BK Ca interacts with the immunomodulator α-2-macroglobulin (α 2 M) and its receptor low-density lipoprotein receptor-related protein 1 in human uterine muscle cells isolated from pregnant women. (pnas.org)
- From this screen, we identified alpha-2-macroglobulin (α 2 M). We then used immunoprecipitation followed by immunoblot and the proximity ligation assay to confirm the interaction between BK Ca and both α 2 M and its receptor, low-density lipoprotein receptor-related protein 1 (LRP1), in cultured primary human myometrial smooth muscle cells (hMSMCs). (pnas.org)
- Alpha 2-macroglobulin , a multifunctional binding protein with targeting characteristics. (thefreedictionary.com)
- Complexes of PSA-alpha 2-M and PSA-ACT were found to bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein (alpha 2-M-R/LRP) which may be the clearance receptor for PSA. (nih.gov)
- Recombinant protein encompassing a sequence within the center region of human alpha 2 Macroglobulin. (genetex.com)
- Download the full report: https://www.reportbuyer.com/product/4368352 Summary Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) - Complement component 5 is a protein is encoded by the C5 gene. (medindia.net)
- C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) pipeline Target constitutes close to 31 molecules. (medindia.net)
- It also reviews key players involved in Complement C5 (C3 And PZP Like Alpha 2 Macroglobulin Domain Containing Protein 4 or C5) targeted therapeutics development with respective active and dormant or discontinued projects.The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. (medindia.net)
- Human alpha 2-macroglobulin (H alpha 2M) is a major IL-1 beta binding plasma protein. (semanticscholar.org)
- Alpha-2-macroglobulin ( α 2-M), a serum protease inhibitor that also binds cytokines, neutralized the inhibitory effect exerted by transforming growth factor- Β (TGF- Β ) on IL-6-induced C-reactive protein (CRP) production by the human hepatoma cell line PLC/PRF/5. (springer.com)
- α2-Macroglobulin (α2M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. (edu.au)
- alpha-2-macroglobulin, also known as α2-macroglobulin (α2M or A2M), is a protein abundant in the plasma of vertebrates and several invertebrates. (ptglab.com)
- Alpha-2-macroglobulin is an abundant secreted protein that is of particular interest because of its diverse ligand binding profile and multifunctional nature, which includes roles as a protease inhibitor and as a molecular chaperone. (edu.au)
- We show that sucrose (but not glycine) effectively protects native alpha-2-macroglobulin from denaturation during freezing and/or lyophilization, thereby providing a reproducible method for the handling and long-term storage of this protein. (edu.au)
- A2M is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. (innov-research.com)
- alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor. (rupress.org)
- Both LB6 clone 19 cells, a mouse cell line transfected with the human uPAR cDNA, and the human U937 monocytic cell line, express in addition to uPAR also the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP/alpha 2-MR) which is required to internalize uPAR-bound uPA-PAI-1 and uPA-PN-1 complexes. (rupress.org)
- Studies support a role for alpha-2-macroglobulin-like 1 protein (A2ML1) in the pathophysiology of otitis media. (nih.gov)
- Alpha 2 macroglobulin is a protein. (livelongstayyoung.com)
- Discovery of FAC as a biomarker for osteoarthritis led to the identification of a naturally-occurring blood protein, Alpha-2 Macroglobulin (A2M), which protects cartilage from degradation and can alleviate joint pain. (cytonics.com)
- Alpha 2 macroglobulin (A2M) uses the most advanced science to not only stop osteoarthritis at its source, but also protect you from a protein complex that causes your joints to ache. (thrivemdvail.com)
- The 1474-amino acid protein is a member of the Protease inhibitor I39 (alpha-2-macroglobulin) family. (biocompare.com)
- A2ML1 (Alpha-2-Macroglobulin Like 1) is a Protein Coding gene. (genecards.org)
- Alpha-2-macroglobulin (a2M) occurs as an acute-phase protein in the rat and in the human brain, and it has been implicated in Alzheimer's disease. (elsevier.com)
- Alpha 2 Macroglobulin (A2M) is a naturally occurring protein that is found in joints and in a person's blood. (checkbiotech.org)
- Alph-2 macroglobulin may yet be one of the most specific markers of microvascular complications in diabetes than any other serum protein . (bvsalud.org)
- These included proteins already studied in the context of CVD (such as apolipoprotein B, alpha-2-macroglobulin), as well as novel findings (such as low density lipoprotein receptor related protein 2 [LRP2], protein SZT2) for which a mechanism of action is suggested. (springer.com)
- CPAMD8 (C3 And PZP Like Alpha-2-Macroglobulin Domain Containing 8) is a Protein Coding gene. (genecards.org)
- Nonproteolytic incorporation of protein ligands into human alpha 2-macroglobulin: implications for the binding mechanism of alpha 2-macroglobulin. (duke.edu)
- alpha 2-Macroglobulin (alpha 2M) is a complex tetrameric protein of 718 kDa. (duke.edu)
- The present study is a further investigation of the properties of alpha 2M with cleaved thiol esters and the potential for incorporation of protein ligands at the site of the thiol ester. (duke.edu)
- After removal of excess NH3, the alpha 2M derivative was incubated with excess protein ligand (hen egg lysozyme or bovine insulin) at 23, 37, or 50 degreesC, leading to covalent incorporation of the ligands in alpha 2M as analyzed by SDS-PAGE, gel filtration, and centrifugal microfiltration. (duke.edu)
- This is the first demonstration of nonproteolytic, covalent incorporation of protein ligands into receptor-recognized alpha 2M. (duke.edu)
- The α-macroglobulins are members of a protein superfamily of structurally related proteins which also comprises complement components C3, C4 and C5. (justia.com)
- The human plasma protein alpha (2) macroglobulin (α2M) is a 720 kDa homotetrameric protein primarily known as a proteinase inhibitor and plasma and inflammatory fluid proteinase scavenger molecule (for review see Chu and Pizzo, 1994, Lab. (justia.com)
- The other proteins were significantly lower at birth than adult values but after 6 months, only albumin, prealbumin, retinol-binding protein, and alpha 1-acid glycoprotein still remained lower in infants. (biomedsearch.com)
- The α 2 -macroglobulin receptor (α 2 MR) or low-density lipoprotein receptor-related protein (LRP) is a cell-surface receptor synthesized as a 600-kd precursor protein (1, 2). (springer.com)
- Sequence identity between the a2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. (springer.com)
- Kristensen T, Moestrup SK, Gliemann J, Bendtsen L, Sand O, Sottrup-Jensen L. Evidence that the newly cloned low-density-lipoprotein receptor related (LRP) protein is the α2-macroglobulin receptor. (springer.com)
- Purified α 2 -macroglobulin receptor/ LDL receptor-related protein binds urokinase: plasminogen activator inhibitor type-1 complex. (springer.com)
- Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/α 2 -macroglobulin receptor. (springer.com)
Antibodies12
- The PSA's proteolytic cleavage triggers the transformation of alpha 2-M as detected by conformation-specific monoclonal antibodies. (nih.gov)
- The PSA bound to alpha 2-M is caged by the inhibitor and thus escapes detection by antibodies. (nih.gov)
- ELISA Kits Human and Animal Rabbit Alpha-2 Macroglobulin ELISA Kit rabbit polyclonal These antibodies are very stable and can be stored up to 2 months at fridge temperature under 10C. (antibody-antibodies.com)
- GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as ELISA Kits Human and Animal Rabbit Alpha-2 Macroglobulin ELISA Kit. (antibody-antibodies.com)
- In this assay the alpha 2-macroglobulin present in the sample reacts with the anti-A2M antibodies, which have been adsorbed to the surface of polystyrene microtiter wells. (antibody-antibodies.com)
- Affinity Biologicals, Inc. manufactures a broad range of A2M - Alpha 2 Macroglobulin Antibodies which can be found in the listing below. (affinitybiologicals.com)
- Our A2M - Alpha 2 Macroglobulin Antibodies are excellent for use in immunoassays where high sensitivity is required and are frequently the preferred reagent for immunopreciptaion techniques and activity neutralization assays. (affinitybiologicals.com)
- Affinity's A2M - Alpha 2 Macroglobulin Antibodies are manufactured for use in research applications. (affinitybiologicals.com)
- Listed below are anti-Alpha-2M antibodies from multiple suppliers. (biocompare.com)
- Your search returned 103 alpha-2M Antibodies across 11 suppliers. (biocompare.com)
- Anti-human alpha 2-Macroglobulin, Goat, Affinity Purified HRP Conjugated IgG (5D-15103G) are polyclonal antibodies recognising multiple binding sites with general applications that may include ELISA, gel precipitation, etc. (quadratech.co.uk)
- To determine if the epitope for 7H11D6 is comprised of residues involved in the alpha 2M receptor determinant, anti-idiotypic antibodies against 7H11D6 were prepared. (duke.edu)
Alpha2-macroglobulin4
- Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. (ebi.ac.uk)
- Transcriptome analysis of NMR liver compared to wild-derived mice revealed very high expression of cell adhesion molecules involved in tumour development as well as the pan- proteinase inhibitor alpha2-macroglobulin (A2M). (fightaging.org)
- I have been using Cytonics' alpha2- macroglobulin kits to treat various joint pains mostly in the knee. (cytonics.com)
- Proteolytic and hemorrhagic activities of BaP1 were readily inhibited by the plasma proteinase inhibitor, alpha2-macroglobulin, and normal mouse serum also inhibited hemorrhage. (lstmed.ac.uk)
Complexes10
- Prostate-specific antigen forms complexes with human alpha 2-macroglobulin and binds to the alpha 2-macroglobulin receptor/LDL receptor-related pro. (nih.gov)
- The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. (patents.com)
- The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. (patents.com)
- The invention also encompasses methods for production of alpha (2) macroglobulin complexes. (patents.com)
- The assay does not detect complexes in normal plasma but reacts with complexes generated by activating normal plasma with dextran sulfate at 4 degrees C in a range of 5 to 375 nmol/L. A close correlation of the ELISA with an amidolytic assay for alpha 2M-Kal was documented. (chaen-rcah.ca)
- Patients with sepsis syndrome but negative bacterial blood cultures did not show elevated plasma complexes, whereas a majority of those with positive blood cultures did show modest elevation and a single patient with septic shock showed a very high level of alpha 2M-Kal complex. (chaen-rcah.ca)
- A competitive enzyme-linked immunosorbent assay demonstrated that the anti-idiotypic IgG competed with alpha 2M-trypsin complexes for binding to 7H11D6. (duke.edu)
- The anti-idiotypic IgG inhibited the binding of 125I-labeled alpha 2M-trypsin complexes to normal rat kidney fibroblasts, and a Kd of 194 pM for the binding of the anti-idiotype to these cells was derived from a fit of the data to a model involving a single class of sites. (duke.edu)
- The invention also encompasses compositions and methods for making alpha (2) macroglobulin-antigenic molecule complexes derived from sera. (justia.com)
- Activity of MMP-1 and MMP-3 in α2 macroglobulin complexes was measured using specific low molecular weight fluorogenic substrates. (tudelft.nl)
Receptor9
- Each monomer of human alpha-2-macroglobulin is composed of several functional domains, including macroglobulin domains, a thiol ester-containing domain and a receptor-binding domain. (wikipedia.org)
- A conserved region in alpha-macroglobulins participates in binding to the mammalian alpha-macroglobulin receptor. (ebi.ac.uk)
- alpha 2M from Limulus shows many of the typical characteristics of mammalian alpha 2M, including the presence of an internal thiol-ester, reactivity with a diversity of endopeptidases, a unique proteinase-trapping mechanism, and reactivity with the mammalian alpha 2M receptor. (nih.gov)
- Trypsin-treated Limulus alpha 2M, but not the native alpha 2M, displaced methylamine-treated human 125I-alpha 2M from the human alpha 2M receptor with a Kd of 30 nM, suggesting conservation of the proteinase-clearance mechanisms between mammalian and arthropod evolutionary lineages. (nih.gov)
- Cleavage of the thiol ester with small nucleophiles destabilizes the native conformation and causes a major conformational change in alpha 2M, which leads to exposure of receptor binding sites and a change in electrophoretic mobility. (duke.edu)
- Receptor binding studies and native pore-limit PAGE confirmed that the alpha 2M derivatives with ligand incorporated remained in the receptor-recognized, 'fast' migrating conformation. (duke.edu)
- Binding of the anti-idiotypic IgG to the alpha 2M receptor provides unequivocal evidence that 7H11D6 is binding to residues within the receptor recognition site on alpha 2M and not merely to residues sufficiently close to that region to cause steric hindrance. (duke.edu)
- En route to the cell surface, the receptor is processed into 515- and 85-kd subunits. (springer.com)
- LRP/α 2 -macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator (t-PA). (springer.com)
Native alpha-2-macroglobul2
- 4ZIU: Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning the residues from domain MG7 to the C-terminus. (rcsb.org)
- The activities of alpha-2-macroglobulin are typically dependent on whether its conformation is native or transformed (i.e. adopts a more compact conformation after interactions with proteases or small nucleophiles), and are also influenced by dissociation of the native alpha-2-macroglobulin tetramer into stable dimers. (edu.au)
Reactivity1
- No significant cross-reactivity or interference between human alpha 2-Macroglobulin and analogues was observed. (assaysolution.com)
Gene5
- Using high-density complementary deoxyribonucleic acid (cDNA) arrays, we identified alpha-2-macroglobulin (α2M) as a differentially expressed gene in replicative senescence. (springer.com)
- Structure of the human alpha 2-macroglobulin gene and its promoter. (thefreedictionary.com)
- This gene encodes a member of the alpha-macroglobulin superfamily. (nih.gov)
- Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. (nih.gov)
- This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. (genecards.org)
Proteins and peptides1
- Alpha (2) macroglobulin promiscuously binds to proteins and peptides with nucleophilic amino acid side chains in a covalent manner (Chu et al. (justia.com)
Inhibits2
- Alpha 2 macroglobulin captures and inhibits the activity of these four groups of proteases. (livelongstayyoung.com)
- Cytonics' recombinant drug development program is anchored in robust preclinical data indicating that the proteinase inhibitor alpha-2-macroglobulin critically inhibits cartilage breakdown in models of osteoarthritis. (cytonics.com)
Inhibitor15
- Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. (ebi.ac.uk)
- No interference was detected from a2- macroglobulin, lysine, unfractionated and low-molecular weight heparln, and ε-amino caproic acid or from the non-plasminogen binding form of plasmin inhibitor. (tudelft.nl)
- Free active MMP is unlikely to be present in plasma: upon entering the circulation, active MMP is expected to be captured by the proteinase inhibitor α2-macroglobulin (α2M). (tudelft.nl)
- Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. (abcam.com)
- Although alpha 2-macroglobulin has been identified as the inhibitor in horse serum, the inhibitors in pig and rabbit sera have not been identified. (nih.gov)
- The inhibitor corresponded in size to alpha 2-macroglobulin and cross-reacted antigenically with human alpha 2-macroglobulin. (nih.gov)
- These data indicate that alpha 2-macroglobulin is the major neutralizing inhibitor of influenza A virus in pig serum. (nih.gov)
- The proteinase inhibitor alpha 2-M has to be considered as a main contributor to PSA complex formation in the blood. (nih.gov)
- Gram-negative bacteria from the human gut microbiome encode a relative of the human endopeptidase inhibitor, α2-macroglobulin (α2M). (rcsb.org)
- Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. (genetex.com)
- In short, alpha 2 macroglobulin is a master inhibitor of cartilage degrading enzymes. (livelongstayyoung.com)
- Alpha 2-Macroglobulin (α2M) is a large proteinase inhibitor molecule of 718,000 daltons, consisting of 4 identical subunits of 185,000 each. (affinitybiologicals.com)
- A2M (Alpha-2-Macroglobulin) is a newly discovered compound that acts as a powerful inhibitor of cartilage breakdown. (nonamedicalarts.com)
- Alpha-2 macroglobulin (Alpha-2-M) is a major plasma protease inhibitor that also regulates the activity of a variety of bioactive peptides including interleukins and exerts a range of immunomodulatory effects. (bvsalud.org)
- Earlier studies have shown that germ cells or germ cell-conditioned media are capable of regulating α2-macroglobulin (α2-MG, a non-specific protease inhibitor) expression by Sertoli cells and hepatocytes cultured in vitro. (hku.hk)
Sequence3
- The entire amino acid sequence is similar to those of the mammalian alpha 2Ms (28-29% identity) and contains common features found in mammalian alpha 2Ms. (nih.gov)
- However, the N-terminal portion (positions 24-105) has no sequence similarity with those of mammalian alpha 2Ms, and it is structurally related to that of the human complement factor C8 chain, consistent with a role for Limulus alpha 2M in host defense. (nih.gov)
- Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins. (semanticscholar.org)
Proteinase inhibitors1
- Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. (semanticscholar.org)
Glycoprotein2
- Alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a tetrameric glycoprotein produced in the liver and found in blood. (bio-rad-antibodies.com)
- identification of a 420-kD cell surface glycoprotein specific for the activated conformation of α 2 -macroglobulin. (springer.com)
Thiol-ester3
- This short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. (ebi.ac.uk)
- In native alpha 2M, each of the four subunits contains a thiol ester between the side chains of Cys949 and Gln952. (duke.edu)
- The thiol ester in alpha 2M was cleaved by NH3. (duke.edu)
Mammalian3
- The component sugar analysis of Limulus alpha 2M showed the existence of a complex type of oligosaccharide chain similar to those of mammalian alpha 2M. (nih.gov)
- However, unlike mammalian alpha 2M, no sialic acid was detected in Limulus alpha 2M and it contained approximately 3 mol/mol N-acetylgalactosamine, suggesting the presence of O-linked sugar chains, which have not been found in mammalian alpha 2M. (nih.gov)
- Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins. (semanticscholar.org)
Inhibit2
- Protease-activated alpha-2-macroglobulin can inhibit amyloid formation" by Amy R. Wyatt, Patrick Constantinescu et al. (edu.au)
- Wild-type alpha-2-macroglobulin ( WT-A2M ) ( left ) and A2M variants CYT-98 and CYT-108 ( right ) inhibit cartilage catabolism induced by TNFα and IL-1β. (biomedcentral.com)
Sepsis2
- We recently reported that levels alpha‐2‐macroglobulin (A2MG)‐containing microparticles are elevated in plasma from patients with sepsis. (embopress.org)
- The ELISA for alpha 2M-Kal appears to be sensitive, specific, and quantitative, and it can be used to reflect the degree of contact system activation in human sepsis and in HAE attacks. (chaen-rcah.ca)
ELISA Kit4
- We can supply standards separately if you suspect the storage was at too high temperature or if your lot nr has passed the expiry date and if you still want to work with the same ELISA Kits Human and Animal Rabbit Alpha-2 Macroglobulin ELISA Kit lot number. (antibody-antibodies.com)
- Do not freeze taw, rather use ELISA Kits Human and Animal Rabbit Alpha-2 Macroglobulin ELISA Kit from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
- ELISA Kits Human and Animal Rabbit Alpha-2 Macroglobulin ELISA Kit Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
- ELISA: Human alpha 2-Macroglobulin ELISA Kit (Colorimetric) - These standard curves are provided for demonstration only. (assaysolution.com)
Plasma11
- alpha-2-Macroglobulin is known to bind zinc, as well as copper in plasma, even more strongly than albumin, and such it is also known as transcuprein. (wikipedia.org)
- 10-15% of copper in human plasma is chelated by alpha-2-macroglobulin. (wikipedia.org)
- The American horseshoe crab Limulus polyphemus contains alpha 2-macroglobulin (alpha 2M) in the hemolymph plasma and hemocytes. (nih.gov)
- Additionally, Limulus alpha 2M has the unique property that it regulates the limulin-based hemolytic system of the plasma. (nih.gov)
- Analysis of Alpha-2 Macroglobulin from the Long-Lived and Cancer-Resistant Naked Mole-Rat and Human Plasma. (nih.gov)
- Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulin. (semanticscholar.org)
- once purified from human blood plasma, however, alpha-2-macroglobulin can undergo a number of conformational changes during storage, including transformation, aggregation or dissociation. (edu.au)
- Some experts in the field of regenerative medicine question the need to concentrate alpha 2 macroglobulin stating that blood plasma has enough alpha 2 macroglobulin to shut down the degrading cartilage enzymes without the need to concentrate it. (livelongstayyoung.com)
- A study of plasma alpha-2-macroglobulin levels in type 2 diabetic subjects with microalbuminuria. (bvsalud.org)
- Plasma Alpha-2-M levels were assayed in 100 (53 males and 47 females ) randomly selected type 2 diabetic subjects with microalbuminuria. (bvsalud.org)
- The increase in plasma alpha-2 macroglobulin levels in diabetes may be a correlative measure to encounter the potential proteolytic challenge associated with diabetic microangiopathy , even very early in the course of the disease . (bvsalud.org)
Characterization1
- Characterization of the inhibitor's oligosaccharide moiety using linkage-specific lectins revealed the presence of N-acetylneuraminic acid-alpha 2,6-galactose but not N-acetylneuraminic acid-alpha 2,3-galactose. (nih.gov)
Inhibitors1
- In addition to tetrameric forms of alpha-2-macroglobulin, dimeric, and more recently monomeric aM protease inhibitors have been identified. (wikipedia.org)
Swine1
- Do not freeze taw, rather use Alpha_2_Macroglobulin, Goat anti_Human, Rabbit, Bovine, Swine, Dog, Cat from the fridge if your use is less than 1 or 2 weeks. (antibody-antibodies.com)
Amino Acid2
- Alpha-2-macroglobulin has in its structure a 35 amino acid "bait" region. (wikipedia.org)
- When High resolution images of rat acute-phase Alpha-2 macroglobulin were performed, studies showed that the comparison of the amino acid compositions of Alpha-2 macroglobulin from Rat and Alpha-2 macroglobulin from human indicated a high degree of homology between the two molecules. (innov-research.com)
Receptors1
- Increased surface hydrophobicity of alpha-2-macroglobulin, as assessed by bisANS fluorescence measurements, is accompanied by (i) reduced trypsin binding activity, (ii) increased chaperone activity, and (iii) increased binding to the surfaces of SH-SY5Y neurons, in part, via lipoprotein receptors. (edu.au)
Western Blot1
- We offer alpha 2-Macroglobulin Lysates for use in common research applications: Western Blot. (novusbio.com)
Serum albumin2
- alpha-2-Macroglobulin levels are increased when the serum albumin levels are low, which is most commonly seen in nephrotic syndrome, a condition wherein the kidneys start to leak out some of the smaller blood proteins. (wikipedia.org)
- It has been reported that Cu(II) ions in human blood are bound mainly to serum albumin (HSA), ceruloplasmin (CP), alpha-2-macroglobulin (α2M) and His, however, data for α2M are very limited and the thermodynamics and kinetics of the copper distribution are not known. (nature.com)
Assay1
- This assay has high sensitivity and excellent specificity for detection of human alpha 2-Macroglobulin. (assaysolution.com)
Cartilage1
- The study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo. (biomedcentral.com)
Alzheimer's1
- A common variant (29.5%) (polymorphism) of alpha-2-macroglobulin leads to increased risk of Alzheimer's disease. (wikipedia.org)
Degeneration3
- Alpha 2 macroglobulin shuts down the destructive processes that leads to joint degeneration and PRP provides the growth factors for repair. (livelongstayyoung.com)
- Koo, P. H. / Alpha-2-macroglobulin homologues mediating nerve degeneration and regeneration . (elsevier.com)
- Alpha 2-macroglobulin can suppress TNF-a-induced activation of NF-?B signaling pathway in CEP cells, thus alleviating the degeneration of IVD. (lww.com)
Peptides2
- Our alpha 2-Macroglobulin Peptides and alpha 2-Macroglobulin Proteins can be used in a variety of model species: Human. (novusbio.com)
- Choose from our alpha 2-Macroglobulin Peptides and Proteins. (novusbio.com)
19891
- 1989. α 2-Macroglobulin traps a proteinase in the midregion of its arms. (springer.com)
Affinity2
- Crookston KP, Webb DJ, Wolf BB, Gonias SLJ (1994) Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. (springer.com)
- The resulting anti-human alpha-2 Macroglobulin (a2M) was solid phase absorbed then affinity purified off an antigen containing immunoabsorbant. (leebio.com)
Thioredoxin1
- Binding of IL-1 beta to alpha-macroglobulins and release by thioredoxin. (semanticscholar.org)
Amyloid1
- Longstanding chronic kidney failure can lead to amyloid by alpha-2-macroglobulin (see main article: amyloid). (wikipedia.org)
Deficiency1
- No specific deficiency with associated disease has been recognized, and no disease state is attributed to low concentrations of alpha-2-macroglobulin. (wikipedia.org)
Molecular weight2
- The concentration of alpha-2-macroglobulin rises 10-fold or more in the nephrotic syndrome when other lower molecular weight proteins are lost in the urine. (wikipedia.org)
- A high molecular weight inhibitory fraction was identified as predominantly alpha-2 macroglobulin and a low molecular weight inhibitory fraction was identified as predominantly alpha-1 antiprotease. (ajtmh.org)
IMSEAR1
- IMSEAR at SEARO: Alpha-2 macroglobulin--new tumour marker? (who.int)
Bait region2
- Binding of PSA to alpha 2-M is initiated by the cleavage of the peptide bond between amino acids Tyr 686 and Glu 687 of the bait region indicating a chymotrypsin-like activity of the PSA. (nih.gov)
- The alpha-macroglobulin bait region. (semanticscholar.org)
Conformation1
- It was reported that the conformation of rat acute-phase Alpha-2 macroglobulin , both at the molecular and secondary structural levels, is strikingly similar to that of human Alpha-2 macroglobulin. (innov-research.com)
Glycoproteins1
- Alpha macroglobulins are large glycoproteins which are present in the body fluids of both invertebrates and vertebrates. (semanticscholar.org)