alpha-L-Fucosidase: An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Methylmalonate-Semialdehyde Dehydrogenase (Acylating): An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Kinetics: The rate dynamics in chemical or physical systems.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Fucosidosis: An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS; GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.FucoseDisaccharidasesOctopodiformes: A superorder in the class CEPHALOPODA, consisting of the orders Octopoda (octopus) with over 200 species and Vampyromorpha with a single species. The latter is a phylogenetic relic but holds the key to the origins of Octopoda.Isoelectric Focusing: Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.Imino Pyranoses: Six-carbon pyranose sugars in which the OXYGEN is replaced by a NITROGEN atom.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Epididymis: The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Sperm Maturation: The maturing process of SPERMATOZOA after leaving the testicular SEMINIFEROUS TUBULES. Maturation in SPERM MOTILITY and FERTILITY takes place in the EPIDIDYMIS as the sperm migrate from caput epididymis to cauda epididymis.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Carbohydrate Metabolism, Inborn ErrorsHydrothermal Vents: Hot springs on the ocean floor. They are commonly found near volcanically active places such as mid-oceanic ridges.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.alpha-Mannosidosis: An inborn error of metabolism marked by a defect in the lysosomal isoform of ALPHA-MANNOSIDASE activity that results in lysosomal accumulation of mannose-rich intermediate metabolites. Virtually all patients have psychomotor retardation, facial coarsening, and some degree of dysostosis multiplex. It is thought to be an autosomal recessive disorder.Lymphocyte Function-Associated Antigen-1: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (ANTIGENS, CD18) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.Glycoside HydrolasesAntigens, CD18: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Cell Adhesion: Adherence of cells to surfaces or to other cells.Pseudogenes: Genes bearing close resemblance to known genes at different loci, but rendered non-functional by additions or deletions in structure that prevent normal transcription or translation. When lacking introns and containing a poly-A segment near the downstream end (as a result of reverse copying from processed nuclear RNA into double-stranded DNA), they are called processed genes.Pacific OceanSearch Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase: A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.Hexosaminidase A: A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits. Deficiency of hexosaminidase A due to mutations in the gene encoding the hexosaminidase alpha subunit is a case of TAY-SACHS DISEASE. Deficiency of hexosaminidase A and HEXOSAMINIDASE B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.Serotyping: Process of determining and distinguishing species of bacteria or viruses based on antigens they share.alpha-Mannosidase: An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.Hexosaminidases: Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.Hexosaminidase B: A mammalian beta-hexosaminidase isoform that is comprized of hexosaminidase beta subunits. Deficiency of hexosaminidase B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.

Endometrial lysosomal enzyme activity in normal cycling endometrium. (1/168)

The objective of this study was to evaluate the possible role of four lysosomal enzymes in endometrial function and remodelling during the normal menstrual cycle by fluorimetric measurement (acid phosphatase, N-acetyl-beta-D-glucosaminidase, alpha-L-fucosidase and alpha-D-mannosidase). A prospective study was conducted of 45 endometrial biopsies obtained from women with normal menstrual cycles. Activity of all four enzymes was identified in human endometrium. Activity of acid phosphatase and N-acetyl-beta-D-glucosaminidase was relatively high, whilst that of alpha-L-fucosidase and alpha-D-mannosidase was low. There was no significant change in the activity of any of the four enzymes from the proliferative to the secretory phase of the cycle. This study suggests that the activity of these enzymes remains constant throughout a major portion of the normal cycle.  (+info)

Characterization of human semen alpha-L-fucosidases. (2/168)

Human semen contains a large amount of alpha-L-fucosidase activity, the great majority of which is found in the seminal fluid. Immunocytochemical studies indicate that a small amount of semen fucosidase activity is present on the sperm plasma membrane, primarily in the posterior head region. Subcellular fractionation studies also indicate that sperm alpha-L-fucosidase is present in the plasma membrane-enriched fraction. Comparative characterization of human seminal fluid and sperm alpha-L-fucosidases indicates that seminal fluid alpha-L-fucosidase has a broad pH optimum curve with a number of near-equal maxima between pH 4.8 and 7.0 while sperm fucosidase has a major optimum between pH 3.4 and 4.0. Isoelectric focusing indicates that seminal fluid alpha-L-fucosidase contains three to six isoforms with isoelectric points (pI) of 5-7 while sperm fucosidase contains two distinct isoforms with pI values of 5. 2 +/- 0.2 and 7.0 +/- 0.2. Western blotting indicates that seminal fluid fucosidase contains a major protein band with a molecular mass ratio (M(r)) of approximately 56 kDa while sperm fucosidase contains a major protein band of approximately 51 kDa. The overall results indicate the presence of a low-abundance, plasma membrane-associated human sperm alpha-L-fucosidase, which is different in its properties from human seminal fluid alpha-L-fucosidase(s), and whose function is not yet known.  (+info)

Fucose in alpha(1-6)-linkage regulates proliferation and histogenesis in reaggregated retinal spheroids of the chick embryo. (3/168)

We have used the lectin from Aleuria aurantia (AAL) which is highly specific for alpha(1-6)-linked fucose, to examine its effect on chicken retinogenesis in a reaggregation culture system. When dispersed cells of the embryonic chick retina are reaggregated to form histotypic retinospheroids, AAL elicits strong inhibition of spheroid growth. The action of AAL is specific, since its effect is dose-dependent, saturable, and inhibited by an excess of fucose. Fucosidase treatment entirely abolishes reaggregation. In contrast, Anguilla anguilla agglutinin (AAA) binding to fucose in alpha(1-2)-linkage does not show any effects. Incubation with CAB4-a specific monoclonal antibody for fucose in alpha(1-6)-linkage-reduces spheroid size and shape. AAL does not much affect primary aggregation, but rather subsequent processes of cell proliferation and histogenesis. In particular, AAL inhibits uptake of bromo-desoxyuridine (BrdU), most efficiently so during days in vitro 2 (div2) and div3. As a consequence, the histological differentiation is entirely disturbed, as evidenced by vimentin immunostaining; particularly, rosettes are not forming and the radial glia scaffold is disorganized. We conclude that glycoproteins exhibiting fucose in alpha(1-6)-linkage may play major roles in early processes of retinal tissue formation.  (+info)

Glycosylation alterations of cells in late phase apoptosis from colon carcinomas. (4/168)

Comparisons of carbohydrate profiles between control and apoptotic colon carcinoma cells were performed by flow cytometry using a set of lectins and anti-carbohydrate antibodies. The six cell lines analyzed presented distinct carbohydrate profiles before induction of apoptosis. PHA-L and MAA binding decreased after induction of apoptosis by UV-treatment. In contrast an increase of PNA binding was observed after induction of apoptosis, except on SW-48 cells for which a decrease occurred. A decrease of SNA binding was observed after induction of apoptosis from strongly positive control cell lines, whereas it increased on weakly positive ones. All the blood group related antigens A, H, Lewis a, Lewis x, Lewis b, and Lewis y, had their expression strongly diminished on apoptotic cells. These changes occurred irrespective of the mode of apoptosis induction since similar results were obtained after UV, TNFalpha, or anti-Fas treatment. Fucosyltransferases activities were also decreased after apoptosis induction, except for alpha1,3fucosyltransferase in anti-Fas treated HT-29 cells, where it was strongly augmented. This could be attributed to the IFNgamma preteatment required to induce Fas expression on these cells. Fucosidase activity decreased after induction of apoptosis suggesting that it was not responsible for the loss of fucosylated structures. In the rat PRO cell line, H blood group antigens are mainly carried by a high molecular weight variant of CD44. It could be shown that the loss of H antigen after induction of apoptosis correlated with a loss of the carrier glycoprotein.  (+info)

Terminal glycosylation in cystic fibrosis. (5/168)

Cystic fibrosis (CF) is a common genetic disease for which the gene was identified within the last decade. Pulmonary disease predominates in this ultimately fatal disease and current therapy only slows the progression. CF transmembrane regulator (CFTR), the gene product, is an integral membrane glycoprotein that normally functions as a chloride channel in epithelial cells. The most common mutation, deltaF508, results in mislocalization and altered glycosylation of CFTR. Altered fucosylation and sialylation are hallmarks of both membrane and secreted glycoproteins in CF and the focus here is on these investigations. Oligosaccharides from CF membrane glycoproteins have the Lewis x, selectin ligand in terminal positions. In addition, two major bacterial pathogens in CF, Pseudomonas aeruginosa and Haemophilus influenzae, have binding proteins, which recognize fucose in alpha1,3 linkage and asialoglycoconjugates. We speculate that the altered terminal glycosylation of airway epithelial glycoproteins in CF contributes to the chronic infection and robust inflammatory response in the CF lung. Understanding the effects of mutant CFTR on glycosylation may provide further insight into the regulation of glycoconjugate processing as well as therapy for CF.  (+info)

Prediction of the development of hepato-cellular-carcinoma in patients with liver cirrhosis by the serial determinations of serum alpha-L-fucosidase activity. (6/168)

OBJECTIVE: Evaluation of the usefulness of the serial determinations of serum alpha-L-fucosidase (AFU) activity for prediction of the development of hepatocellular carcinoma (HCC) was performed. METHODS AND PATIENTS: Serum AFU activity was determined monthly for 42 months in 73 patients with liver cirrhosis (LC). RESULTS: HCC was diagnosed in 27 patients by means of ultrasonography during this observation period. In 23 (85%) of the 27 patients, serum AFU activity was found to exceed 700 nmole/ml/h during the LC stage. HCC developed within a few years in 23 (82%) of 28 LC patients with AFU activity exceeding 700 nmole/ml/h, in contrast, it developed in only 4 (9%) of 45 LC patients with AFU activity below 700 nmole/ml/h. AFU activity was already elevated in 23 (85%) of 27 patients at least 6 months before the detection of HCC by ultrasonography. CONCLUSION: It is conceivable that the development of HCC can be predicted by means of serial determinations of serum AFU activity in patients with LC.  (+info)

Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women. (7/168)

The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal enzymes in three contrasting groups: (i) women with ovulatory dysfunctional uterine bleeding and users of intrauterine contraceptive devices; (ii) breastfeeding post-partum women in whom there are long periods of amenorrhoea, particularly in the early months post-partum; and (iii) normal cycling women. It was found that the total activity of lysosomal enzymes, particularly acid phosphatase and N-acetyl-beta-D-glucosaminidase, was markedly elevated (P < 0.001) in IUCD-exposed endometrium, and endometrium from women with dysfunctional uterine bleeding when compared with endometrium from women with a history of entirely normal menstrual periods or that in post-partum breastfeeding women. The activity of alpha-L-fucosidase was moderately elevated in IUCD users (P < 0.05) and ovulatory dysfunctional uterine bleeding (P < 0.05), whereas alphaD-mannosidase activity was elevated in ovulatory dysfunctional uterine bleeding (P < 0.05), but decreased in IUCD users (P < 0.01). No significant differences were observed in the lysosomal enzyme activities of breastfeeding post-partum women and normal cycling women. These results show that total endometrial tissue activity of four lysosomal enzymes was substantially increased throughout the cycle in most circumstances in women with two different causes for increased menstrual bleeding. This suggests a contributory role to the increased bleeding.  (+info)

Sequence and expression of Thai Rosewood beta-glucosidase/beta-fucosidase, a family 1 glycosyl hydrolase glycoprotein. (8/168)

Dalcochinin-8'-O-beta-glucoside beta-glucosidase (dalcochinase) from the Thai rosewood (Dalbergia cochinchinensis Pierre) has aglycone specificity for isoflavonoids and can hydrolyze both beta-glucosides and beta-fucosides. To determine its structure and evolutionary lineage, the sequence of the enzyme was determined by peptide sequencing followed by PCR cloning. The cDNA included a reading frame coding for 547 amino acids including a 23 amino acid propeptide and a 524 amino acid mature protein. The sequences determined at peptide level were found in the cDNA sequence, indicating the sequence obtained was indeed the dalcochinase enzyme. The mature enzyme is 60% identical to the cyanogenic beta-glucosidase from white clover glycosyl hydrolase family 1, for which an X-ray crystal structure has been solved. Based on this homology, residues which may contribute to the different substrate specificities of the two enzymes were identified. Eight putative glycosylation sites were identified, and one was confirmed to be glycosylated by Edman degradation and mass spectrometry. The protein was expressed as a prepro-alpha-mating factor fusion in Pichia pastoris, and the activity of the secreted enzyme was characterized. The recombinant enzyme and the enzyme purified from seeds showed the same K(m) for pNP-glucoside and pNP-fucoside, had the same ratio of V(max) for these substrates, and similarly hydrolyzed the natural substrate, dalcochinin-8'-beta-glucoside.  (+info)

*Alpha-L-fucosidase

1,2-alpha-L-fucosidase 1,3-alpha-L-fucosidase 1,6-alpha-L-fucosidase FUCA2 Endreffy I, Bjørklund G, Szerafin L, Urbina MA, ... In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction an alpha-L-fucoside + H2O ... The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This ... doi: 10.1007/s12026-017-8943-x. Levvy GA, Mcallan A (August 1961). "Mammalian fucosidases. 2. alpha-L-Fucosidase". The ...

*1,2-alpha-L-fucosidase

In enzymology, a 1,2-alpha-L-fucosidase (EC 3.2.1.63) is an enzyme that catalyzes the chemical reaction methyl-2-alpha-L- ... Other names in common use include almond emulsin fucosidase, and alpha-(1->2)-L-fucosidase. As of late 2007, 4 structures have ... 2-alpha-L-fucosidase". J. Biol. Chem. 245 (2): 299-304. PMID 5460888. Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L- ... Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66 (2): 379-87. doi:10.1111/j.1432 ...

*1,3-alpha-L-fucosidase

In enzymology, a 1,3-alpha-L-fucosidase (EC 3.2.1.111) is an enzyme that catalyzes the chemical reaction of cleaving the 1,3- ... Yoshima H, Takasaki S, Ito-Mega S, Kobata A (1979). "Purification of almond emulsin alpha-L-fucosidase I by affinity ... Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L-fucosidases from almond emulsin: characterization of the two enzymes ... The systematic name of this enzyme class is 3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase. This enzyme is ...

*1,6-alpha-L-fucosidase

This enzyme is also called alpha-L-fucosidase. Yazawa S, Madiyalakan R, Chawda RP, Matta KL (1986). "alpha-L-fucosidase from ... 6-alpha-L-fucosidase (EC 3.2.1.127) is an enzyme that catalyzes the chemical reaction Hydrolysis of 1,6-linkages between alpha- ... aspergillus niger: demonstration of a novel alpha-L-(1----6)-fucosidase acting on glycopeptides". Biochem. Biophys. Res. Commun ...

*Fucosidase

Tissue alpha-L-fucosidase is an enzyme that in humans is encoded by the FUCA1 gene. Alpha-Fucosidase is an enzyme that breaks ... "Entrez Gene: FUCA1 fucosidase, alpha-L- 1, tissue". HPRD entry [1] Willems PJ, Gatti R, Darby JK, et al. (1991). "Fucosidosis ... Fukushima H, de Wet JR, O'Brien JS (1985). "Molecular cloning of a cDNA for human alpha-L-fucosidase". Proc. Natl. Acad. Sci. U ... Yang M, Allen H, DiCioccio RA (1993). "A mutation generating a stop codon in the alpha-L-fucosidase gene of a fucosidosis ...

*Fucosidosis

The gene encoding the alpha-fucosidase, FUCA 1, was found to be located to the short arm of chromosome 1p36 - p34, by Carrit ... If they are present, a skin or blood sample will be taken to test for below-normal amounts of alpha-fucosidase. - Fucosidosis ... The FUCA1 gene provides instructions for making an enzyme called alpha-L-fucosidase. The enzyme plays a role in the breakdown ... The deficiency of the enzyme alpha-L-fucosidase, which is used to metabolize complex compounds in the body (fucose-containing ...

*Glycoside hydrolase family 29

Alpha-L-fucosidase is responsible for hydrolysing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of ... Glycoside hydrolase family 29 includes alpha-L-fucosidases, They are lysosomal enzymes responsible for hydrolyzing the alpha-1, ... making alpha-l-fucosidases, the enzymes responsible for their processing, critically important. Deficiency in alpha-l- ... In human sperm, membrane-associated alpha-l-fucosidase is stable for extended periods of time, which is made possible by ...

*FUCA2

Plasma alpha-L-fucosidase (see alpha-L-fucosidase) is an enzyme that in humans is encoded by the FUCA2 gene. GRCh38: Ensembl ... "Entrez Gene: FUCA2 fucosidase, alpha-L- 2, plasma". Narahara K, Tsuji K, Yokoyama Y, et al. (1991). "Specification of small ... 2001). "Cell surface human alpha-L-fucosidase". Eur. J. Biochem. 268 (11): 3321-31. doi:10.1046/j.1432-1327.2001.02237.x. PMID ... 1988). "Molecular biology of the alpha-L-fucosidase gene and fucosidosis". Enzyme. 38 (1-4): 45-53. PMID 2894306. Cordero OJ, ...

*Macrococcus brunensis

... alpha-galactosidase, N-acetyl-beta-glucosaminidase, alpha-mannosidase, alpha-fucosidase and esterase-lipase (C8) are negative. ... Acid is not produced from arabinose, N-acetylglucosamine, D-cellobiose, D-galactose, or methyl alpha-D-glucoside, lactose, D- ...

*Thymidine kinase in clinical chemistry

Zhang SY, Lin BD, Li BR (2015). "Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine ...

*Penicillium multicolor

"An alpha-L-fucosidase from Penicillium multicolor as a candidate enzyme for the synthesis of alpha (1-->3)-linked fucosyl ... Penicillium multicolor is an anamorph species of the genus of Penicillium which produces alpha-L-fucosidase, tilactase, ... Ajisaka, K.; Fujimoto, H.; Miyasato, M. (1998). "An α-l-fucosidase from Penicillium multicolor as a candidate enzyme for the ...

*Fucoidanase

... alpha-L-fucosidase, poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase) is an enzyme with systematic name poly((1->2)-alpha- ... This enzyme catalyses the following chemical reaction Endohydrolysis of (1->2)-alpha-L-fucoside linkages in fucoidan without ...

*List of EC numbers (EC 3)

2-alpha-L-fucosidase EC 3.2.1.64: 2,6-b-fructan 6-levanbiohydrolase EC 3.2.1.65: levanase EC 3.2.1.66: quercitrinase EC 3.2. ... 3-alpha-L-fucosidase EC 3.2.1.112: 2-deoxyglucosidase EC 3.2.1.113: mannosyl-oligosaccharide 1,2-a-mannosidase EC 3.2.1.114: ... 6-alpha-L-fucosidase EC 3.2.1.128: glycyrrhizinate beta-glucuronidase EC 3.2.1.129: endo-a-sialidase EC 3.2.1.130: glycoprotein ... alpha-agarase EC 3.2.1.159: alpha-neoagaro-oligosaccharide hydrolase EC 3.2.1.160: now EC 3.2.1.155 EC 3.2.1.161: beta-apiosyl- ...

*List of MeSH codes (D08)

... alpha-L-fucosidase MeSH D08.811.277.450.410 --- galactosidases MeSH D08.811.277.450.410.050 --- alpha-galactosidase MeSH ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 --- gtp-binding protein alpha subunits, gq-g11 ... gtp-binding protein alpha subunits, g12-g13 MeSH D08.811.277.040.330.300.200.100.200 --- gtp-binding protein alpha subunits, gi ... steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 --- steroid 16-alpha-hydroxylase MeSH D08.244.453.915.748 --- steroid 17- ...

*Pseudogymnoascus destructans

... alpha/beta-galactosidase, β-glucuronidase, α-fucosidase, α-mannosidase, and trypsin. Important dual virulence factors found in ...

*Beta-D-fucosidase

... beta-D-glucosides and alpha-L-arabinosides. Chinchetru, M.A.; Cabezas, J.A.; Calvo, P. (1983). "Characterization and kinetics ... Beta-D-fucosidase (EC 3.2.1.38, beta-fucosidase) is an enzyme with systematic name beta-D-fucoside fucohydrolase. This enzyme ... Beta-D-fucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular Biology portal ... Rodriguez, J.A.; Cabezas, J.A.; Calvo, P. (1982). "β-Fucosidase, β-glucosidase and β-galactosidase activities associated in ...
For further information read more below or download the product sheet. Enzyme activity: Fuc123 Alpha-Fucosidase is a glycosyl hydrolase that cleaves alpha-glucan residues from various alpha-fucosylated oligosaccharides including hydrolysis of alpha-L-fucose from algal fucosidan (Ascophyllum nodosum).. Activity determination: The standard assay is performed by mixing 10 μL enzyme sample to 80 μL of 125mM phosphate buffer at pH 6,5 with 20 μL PNP-alpha-fucopyranoside, incubated at 65°C. Reaction is stopped with 200μL 0,5M sodium borat and OD measured at 405 nm. Unit definition: One unit of activity is defined as the amount of enzyme, which liberates 1 μmol of p-nitrophenol per minute under the given assay conditions.. Synonyms: glycoside hydrolase, alpha-L-fucoside fucohydrolase, alpha-fucosidase. Protein family: Glycosyl hydrolase family. Enzyme classification: EC 3.2.1.51. Source: Proprietary environmental DNA. Substrates:. Fucoidan is a group of sulfated polysaccharides containing fucose ...
Alpha-Fucosidase enzymes release non-reducing terminal linked fucose from N and O-glycans. These products may be used in the sequence analysis of N-glycans as w
Définitions de 1 3 alpha l fucosidase, synonymes, antonymes, dérivés de 1 3 alpha l fucosidase, dictionnaire analogique de 1 3 alpha l fucosidase (anglais)
Alpha-l-fucosidase (AFU) plays vital roles in some physiological processes that closely relate to several diseases. Herein, a ratiometric fluorescent probe for the alpha-l-fucosidase (AFU) assay based on a single fluorophore has been developed by functionalizing a new fluorophore platform (6-bromo-anthracene MCF Editors Recommendation
While the catalytic nucleophile in the configuration-retaining alpha-L-fucosidases from family GH29 is fully conserved with respect to sequence, there is no fully sequence-conserved acid/base residue candidate across the family. X-ray crystallographic studies and kinetic characterizations have allowed the identification of this residue in a few cases, and a recent combination of phylogenetic tree analyses with substrate specificity data has allowed the division of GH29 enzymes into two subfamilies, A and B, allowing the probable assignment of these residues. Here, we perform detailed kinetic and mechanistic characterizations of the corresponding alanine mutants and other candidates. Through comparison of kinetic parameters obtained for the hydrolysis of fucosyl substrates with activated leaving groups by these mutants with those of the corresponding wild-type enzymes, in conjunction with the demonstration of azide rescue, we largely confirm the acid/base residue predictions for the GH29 ...
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
BioAssay record AID 36841 submitted by ChEMBL: Inhibition of the enzyme alpha-L-fucosidase from bovine epididymis was determined at 1 mM concentration of the compound; No inhibition.
K01186 NEU1; sialidase-1 [EC:3.2.1.18] K01186 NEU1; sialidase-1 [EC:3.2.1.18] K01190 lacZ; beta-galactosidase [EC:3.2.1.23] K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] K12373 HEXA_B; hexosaminidase [EC:3.2.1.52] K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] K01227 E3.2.1.96; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96] K01206 FUCA; alpha-L-fucosidase [EC:3.2.1.51] K15923 AXY8; alpha-L-fucosidase 2 [EC:3.2.1.51 ...
Complete information for FUCA1P1 gene (Pseudogene), Alpha-L-Fucosidase 1 Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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A series of phenyl-D-thioglucopyranosides were prepared and characterized in order to determine the absolute specificity of the .B-thioglucosidase and B-glucosidese enzyme systems toward the th1oglucosidic bond. The specificity of B-glucosidase of almond emulsin toward oxygen linkage seems to be absolute, since no hydrolysis was observed by this enzyme system toward the phenyl-D-thioglucopyranosides. The P-th1oglucosidase system was found to hydrolyze only two of the thioglucopyranosides. It was apparent that only where the electron-attracting substituents in the phenyl group were strong enough to greatly weaken the strength of the sulfur linkage, as in the case of the nitro group, would there be any hydrolysis. The lack of hydrolysis prevented application of the Hammett equation in testing the quantitative electronic effects of the substitutents on the rate of bond hydrolysis.
Complete information for FUCA1 gene (Protein Coding), Fucosidase, Alpha-L- 1, Tissue, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.- ...
endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (3.2.1.21); β-glucuronidase (EC 3.2.1.31); β-xylosidase (EC 3.2.1.37); β-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); β-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-β-1,4-xylanase (EC 3.2.1.136); endo-β-1,6-galactanase (EC:3.2.1.164); [reducing end] β-xylosidase (EC 3.2.1.- ...
Fast delivery of FUCA2 knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes matched wildtype control.
References for Abcams Recombinant Human FUCA2 protein (ab117022). Please let us know if you have used this product in your publication
The molecular basis of the deficiency of alpha-L-fucosidase has been investigated in eight patients who had been diagnosed clinically and enzymatically as suffering from the autosomal recessive lysosomal storage disease fucosidosis. None of the patients had a deletion or gross alteration of the alpha-L-fucosidase gene (FUCA1). Single strand conformation polymorphism (SSCP) analysis followed by direct sequencing of amplified exons and flanking regions identified putative disease causing mutations in six of the patients, who had severe forms of the disease and very low residual alpha-L-fucosidase activity and protein. They were a 10 bp deletion in exon 1 (E113fs), a 1 bp deletion at position -2 of intron 2 (S216fs), a g--,a transition at IVS5+1, point mutations W183X and N329Y in exons 3 and 6, respectively, and a compound allele consisting of a point mutation in the signal peptide in exon 1, P5R, and a 1 bp insertion in exon 6 (Y330fs). One patient in whom an SSCP change was not detected had ...
1ODU: Crystal Structure of Thermotoga Maritima {Alpha}-L-Fucosidase: Insights Into the Catalytic Mechanism and the Molecular Basis for Fucosidosis
Fucosidosis is a rare lysosomal storage disorder caused by the inherited deficiency of the lysosomal hydrolase α-L-fucosidase, which leads to an impaired degradation of fucosylated glycoconjugates. Here we report the generation of a fucosidosis mouse model, in which the gene for lysosomal α-L-fucosidase (Fuca1) was disrupted by gene targeting. Homozygous knock-out mice completely lack α-L-fucosidase activity in all tested organs leading to highly elevated amounts of the core-fucosylated glycoasparagine Fuc(α1,6)-GlcNAc(β1-N)-Asn and, to a lesser extent, other fucosylated glycoasparagines, which all were also partially excreted with the urine. Lysosomal storage pathology was observed in many visceral organs like liver, kidney, spleen and bladder as well as in the CNS. On the cellular level storage was characterized by membrane-limited cytoplasmic vacuoles primarily containing water-soluble storage material. In the CNS cellular alterations included enlargement of the lysosomal compartment in ...
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InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
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Expression of FUCA2 in human tissue. Overview of the antibody staining with HPA031659, HPA031660 and HPA031661 in immunohistochemistry
Expression of FUCA2 (dJ20N2.5, MGC1314) in caudate tissue. Antibody staining with HPA031659, HPA031660 and HPA031661 in immunohistochemistry.
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In terms of performance, users should keep in mind that the warm-up time during a power failure, pull down time, uniformity a ...
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At least 26 mutations in the FUCA1 gene have been found to cause fucosidosis. Most of these mutations result in an abnormally short, nonfunctional alpha-L-fucosidase enzyme. Without this enzyme, glycolipids and glycoproteins cannot be completely broken down. These partially broken down compounds accumulate in the lysosomes and cause cells throughout the body to malfunction. Brain cells are particularly sensitive to the buildup of glycolipids and glycoproteins, which can result in cell death. Loss of brain cells is thought to cause the neurological symptoms of fucosidosis. Accumulation of glycolipids and glycoproteins also occurs in other organs such as the liver, spleen, skin, heart, pancreas, and kidneys, contributing to the additional symptoms of fucosidosis. ...
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Background: Some salivary markers of alcohol abuse/dependence have been proposed so far: aminotransferases, gamma-glutamyltransferase, ethanol, ethyl glucuronide, ethyl sulfate, sialic acid, β-hexosaminidase A, oral peroxidase, methanol, diethylene/ethylene glycol, α-amylase, clusterin, haptoglobin, heavy/light chains of immunoglobulins and transferrin. Aim: To investigate the effect of chronic alcohol drinking and smoking on the activity (pKat/ml) and output (pKat/min) of salivary lysosomal exoglycosidases: α-fucosidase (FUC), α-mannosidase (MAN), β-galactosidase (GAL), and β-glucuronidase (GLU), and their applicability as markers of alcohol dependence. Methods: The activity of FUC, MAN, GAL and GLU was measured colorimetrically in the saliva of healthy social drinkers, alcohol-dependent non-smokers and alcohol-dependent smokers. Results: We observed an increased salivary activity of FUC, GAL, GLU and MAN, as well as an increased output of GAL and GLU, in comparison with controls. The ...
Catheter ablation of atrial fibrillation (AFCA) efficacy in patients with impaired left ventricular systolic function improves when performed early in the natural history of atrial fibrillation (AF) and heart failure, according to a study published recently in Circulation: Arrhythmia and Electrophysiology.1 AFCA provides long-term benefits on left ventricular function, significantly reducing the number of patients with severely impaired systolic function, the authors add. ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
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Zhao, Y, Chen, L, Yakubov, G, Aminiafshar, T, Han, L and Lian, G (2012) Erratum: Experimental and theoretical studies on the binding of epigallocatechin gallate to purified porcine gastric mucin (Journal of Physical Chemistry B (2012) 116 DOI:10.1021/jp212059x) ...
Looking for online definition of AFU or what AFU stands for? AFU is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Sperm-associated antigen 8 is a protein that in humans is encoded by the SPAG8 gene. The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein encoded by this gene is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined. GRCh38: Ensembl release 89: ENSG00000137098 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000066196 - Ensembl, May 2017 "Human PubMed Reference:". ...
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Plasminogen, the proenzyme of the fibrinolytically active enzyme plasmin, is a single chain glycoprotein with a molecular weight of about 90,000-94,000 Da (2). Various isoelectric forms exist and can be separated by means of isoelectric focusing (IEF).
According to the medical personnel of the AFU units (Ukrainian troops) there were recorded mass diseases among the Ukrainian military personnel in the field. Physicians recorded the unknown virus as a result of which the infected get the high fever which cannot be subdues by any medicines, and in two days there comes the fatal outcome. Thus far from the virus there have died more than twenty servicemen, what is carefully shielded by the commandment of the AFU from the publicity", said Basurin in daily MoD situation report ...
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Toshiba has begun shipping a 14TB helium-filled hard drive to clients, its largest capacity to date and the company's first foray into helium territory. Of course, helium-filled HDDs are not new, and WD already released a 14TB HDD a couple of months ago. However, Toshiba's is the industry's first HDD to pack nine disks inside, and the only 14TB drive to use conventional magnetic recording (CMR) technology.The new drive is part of Toshiba's MG07ACA series. It is available in both 12TB and 14TB capacities, both of which are CMR drives.We have raised the bar with the new MG07ACA Series 9-disk helium-sealed design, said Akitoshi Iwata, Vice President of Storage Products Division, Toshiba Electronic Devices and Storage Corporation. By utilizing an innovative design, we continue to improve the benefits that high-capacity disk storage can deliver to our broad global customer base.There are a couple of things to note about the 14TB model that make it sta
A software developer now living in Copenhagen with interest in Biology, Bioinformatics, Computational Biology. rokhline/yahoo/com/au ...
... is a probiotic found mostly in the digestive system which has been used to protect the body from harmful bacteria and to maintain or restore a normal, healthy condition in the intestines
Bifidobacterium bifidum, known as B. bifidum, is a strain of bacteria commonly used as a probiotic. Probiotics are living microorganisms that simulate the...
α-L-fucosidase (EC 3.2.1.51) [1] is a lysosomal enzyme responsible for hydrolyzing the α-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of α-L-fucosidase results in the lysosomal storage disease fucosidosis. A cysteine residue is important for the activity of the enzyme. There is only one cysteine conserved between the sequence of mammalian α-L-fucosidase and that of the slime mold Dictyostelium discoideum. We have derived a pattern from the region around that conserved cysteine. Note: These proteins belong to family 29 in the classification of glycosyl hydrolases [2,E1]. Last update: May 2004 / Text revised. ...
Mucopolysaccharidosis like inherited storage disorders. Four have been identified so far: muramidase deficiency (ML I), I cell disease (ML II), pseudo Hurler polydystrophy (ML III), and sialicosis (ML IV, also called fucosidosis). Abbreviated ML
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014 ...
Mucolipidosis II (I-cell disease) and mucolipidosis IIIA (classical pseudo-hurler polydystrophy) are caused by mutations in the GlcNAc-phosphotransferase alpha / beta -subunits precursor gene. Kudo M, Brem MS, Canfield WM Am J Hum Genet. 2006 Mar;78(3):451-63. For more information on Mucolipidosis II and mucolipidosis IIIA, please visit OMMBID Chapter 138. Thank you very much in advance […]. ...
食品、饮料与营养保健品 (Glycosidase) | 食品、饮料与营养保健品 一站式进行配方,数据表,物质安全数据表搜索,产品特性和样品申请 -- 免费使用
Normark, W.R., Morton, J.L., and Delaney, J.R., 1982, Geologic setting of massive sulfide deposits and hydrothermal vents along the southern Juan de Fuca Ridge: U.S. Geological Survey Open-File Report 82-0200-A, 22 p. Koski, Randolph A., Normark, William R., Morton, Janet L., and Delaney, John R., 1982, Metal sulfide deposits on the Juan de Fuca Ridge: Woods Hole, MS, Oceanus, v. 25, no. 3, Deep ocean mining, p. 43-48. Normark, William R., Lupton, John E., Murray, James W., Koski, Randolph A., Clague, David A., Morton, Janet L., Delaney, John R., and Johnson, H. Paul, 1982, Polymetallic sulfide deposits and water-column tracers of active hydrothermal vents on the southern Juan de Fuca Ridge, in Special issue, Polymetallic sulfides: Marine Technology Society Journal, v. 16, no. 3, p. 46-53. Delaney, J.R., Koski, Randolph A., Clague, D.A., Bischoff, J.L., and Normark, William R., 1982, Massive zinc and iron-rich sulfide deposits associated with hot springs, Juan de Fuca Ridge, in American ...
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PROCESS FOR PRODUCING AN OXIDIZED NANOFIBRILLAR CELLULOSE HYDROGEL | METHOD AND APPARATUS FOR CONTROLLING THE CATALYTIC OXIDATION OF CELLULOSE | MULTISPECIFIC ANTIBODIES | OPTIMIZED CROSS-SPECIES SPECIFIC BISPECIFIC SINGLE CHAIN ANTIBODY CONTRUCTS | C-MET ANTIBODY COMBINATIONS |
As energy saving regulations are gradually tightened and products continue to be miniaturized, demand is increasing for microcontrollers (MCUs) with low pin-count that can efficiently control multiple motors. The new products meet requirements for the motor control systems of home appliances, such as air-conditioners, and are based on the ARM® Cortex®-M4F, which incorporates a floating point processing unit. Integrated features include a high-precision AD convertor with a 0.5 μs conversion speed, high-speed Flash memory with 80 MHz operation, and a co-processor for Toshibas original vector engine. Together, they ensure the new products realize efficient motor control while improving the power factor and system control.. ...
glycosidase Definition, glycosidase Best Plays of glycosidase in Scrabble® and Words With Friends, Length tables of words in glycosidase, Word growth of glycosidase, Sequences of glycosidase
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In the previous communication of this series (No. XII, 1908, B, Vol. 80, pp. 321-329) the contention was advanced that "emulsinprepared from sweet almonds contains at least three distinct enzymes, viz., amygdalase, a β-glucase and gluco-lactase: the first of these, amygdalase, being the enzyme by which amygdalin is resolved into glucose and Fiscliers glucoside, β-glucase that by which β-glucosides are hydrolysed, gluco-lactase that which hydrolyses milk sugar. Meanwhile the striking discovery has been made by Rosenthaler that emulsin has the property of inducing the formation of dextro-rotatory benzylidenecyanhydrol-such as may be obtained from amygdalin-from benzaldehyde and hydrogen cyanide; this raises the question whether there may not also be present in "emulsin" a specific enzyme capable of operating on the cyanophoric radicle of amygdalin and of resolving it into hydrogen cyanide and benzaldehyde. To avoid periphrasis this hypothetical enzyme may be spoken of as benzcyancise. ...
Bifidobacterium bifidum is a bacterial species of the Bifidobacterium genus. B. bifidum is one of the most common probiotic bacteria that can be found in the body of mammals, including humans. Since B. bifidum is a Gram-positive bacterium that is not motile, anaerobic, and not spore-forming. The bacterium is rod-shaped and can be found living in clusters, pairs, or even independently. The majority of the population of B. bifidum is found in the colon, lower small intestine, breast milk, and often in the vagina.[citation needed] The use of B. bifidum in probiotic applications may reduce the chances of acute diarrhea and the risk of E. coli infections, and contributes to the maintenance of vaginal homeostasis. The manipulation of the gut flora is complex and may cause bacteria-host interactions. Although probiotics, in general, are considered safe, there are concerns about their use in certain cases. Some people, such as those with compromised immune systems, short bowel syndrome, central venous ...
T-cells infiltrating sites of inflammation of the skin typically express the cutaneous lymphocyte-associate antigen (CLA). This antigen is defined by the binding of the monoclonalCLA antibody HECA-452. The CLA antigen is a fucose-containing oligosaccharide and is found on many of the ligands that are recognized by the adhesion proteins P-selectin and E-selectin.
Xu, F., Zhen, P., Zheng, Y., LIjuan, F., Aiting, Y., Min, C., Hong, Y. and Jidong, J. (2013), Preparation of Kupffer cell enriched non-parenchymal liver cells with high yield and reduced damage of surface markers by a modified method for flow cytometry. Cell Biology International, 37: 284-291. doi: 10.1002/cbin.10035 ...
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Although Sun is listed by IDC in the Others category, it grew disk storage system sales 25 per cent in its second consecutive quarter of revenue growth, with 16.1 per cent growth in external disk systems. The company sold more disk storage for Unix servers than any other supplier has done, it claimed, for the past 20 consecutive quarters. If the new Open Storage products take off then it could start approaching Hitachi and NetApp. That would be a noteworthy feat.. IDC shows IBM losing a huge share of the total disk market because, presumably, its customers bought networked storage from other vendors for IBM servers. Dell suffered the same way but to a lesser extent and is flatlining in external disk storage sales. The big winners are EMC, growing faster than NetApp and solidifying its number one spot, and NetApp. If these trends continue NetApp will overtake Hitachi in total disk storage sales and catch up with Dell in external disk storage sales. The rebranding and focus on new customers is ...
L-Fucose CT is a naturally occurring sugar in a white crystalline powder form. This product is most commonly used in functional food applications.
The IUPHAR/BPS Guide to Pharmacology. amylase, alpha 2A (pancreatic) - 3.2.1.- Glycosidases. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
The starch and protein in wheat (Triticum aestivum L.) endosperm provide 20% of the calories eaten by humans and were heavily selected for during domestication. We examined the main storage products and gene expression patterns that may embody compositional differences between two wild species Aegilops crassa and Aegilops tauschii and cultivated bread wheat. The storage product profiles differed significantly with T. aestivum accumulating twice as much carbon as the wild species, while the latter had 1.5 to 2-fold more total nitrogen per seed. Transcriptional analyses of endosperms of similar fresh weight were compared using a cDNA macroarray. Aegilops tauschii, and especially Ae. crassa had stronger hybridizations with storage protein sequences, but while there were differences in transcripts for starch biosynthetic genes, they were less dramatic. Of these, we cloned the Starch Branching Enzymes (SBE) IIa promoter region and the genomic clone of the Brittle-1 (Bt1) ADPglucose transporter. While ...
Mucous membranes are covered with mucus, a viscoelastic hydrogel that plays an essential role in their protection from shear and pathogens. The viscoelasticity of mucus is owing to mucins, a group of densely glycosylated proteins. Mucins can interact with a wide range of surfaces; thus, there is big interest in exploring and manipulating such interactions for biomedical applications. This thesis presents investigations of mucin interactions with hydrophobic surfaces in order to identify the key features of mucin lubricity, as well as describes the development of materials that are optimized to interact with mucins.. In Paper I we investigated the domains which make mucins outstanding boundary lubricants. The results showed that the hydrophobic terminal domains of mucins play a crucial role in the adsorption and lubrication on hydrophobic surfaces. Specifically, protease digestion of porcine gastric mucins and salivary mucins resulted in the cleavage of these domains and the loss of lubricity and ...
The kinetic adsorption-desorption behaviour of porcine gastric mucin in the presence of physiologically relevant concentrations of the polyphenol epigallocatechin gallate (EGCG) was investigated using high-resolution kinetic optical waveguide lightmode spectroscopy (OWLS) and atomic force microscopy (AFM). Comparison with dynamic light scattering results from EGCG-mucin mixtures indicates that discrete particles are formed whose size increases with increasing EGCG:mucin ratio. These particles are deduced to be the adsorbing entities, which fuse on the surface to form complex surface layers. At low molar EGCG:mucin ratios ...
Glycosidase activities in principal cells, basal cells, fibroblasts and spermatozoa isolated from the rat epididymis.: The activity levels of beta-N-acetylgluco
Dear Straight Dope:. I have heard from numerous sources (many of them seemingly credible) that the average human consumes an average of four spiders per year in his or her sleep. Is there any truth to this fact? And if so, why would the spiders go in our mouths?. - Michael OShea. SDStaff Doug replies:. Amazingly, I cannot find this one debunked in either the alt.folklore.urban or snopes urban legend archives. I know its been debunked in the AFU newsgroup - Ive been in on the debunking personally, but none of that comes up in a search on the AFU archive. So its up to me to do what must be done.. One amazing thing about urban legends is that they never appear the same way twice. This statistic variously appears as 10 per year, 57 per year, 19 per year, and all sorts of other numbers. No one can ever tell you where the statistic came from originally, either.. Realistically, the average number of spiders swallowed at night per person per lifetime is probably less than one. After all, most people ...
None of the Afu predictions have been verified as RNA transcripts by primer extension. Exceptions to consensus box features shown in red. Predicted methylation guide regions with Watson-Crick/G-U base pairings to target RNAs shown in green. Predicted terminal stem pairings shown in blue. 5 and 3 ends of sRNAs were not determined experimentally (an invariant 10 nucleotides of sequence flanking the C box and D boxes is displayed ...
This graph shows the total number of publications written about "Gastric Mucins" by people in this website by year, and whether "Gastric Mucins" was a major or minor topic of these publications ...
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At work, I encountered an interesting problem: While testing the Fibre Channel (FC) scalability of a storage product, we needed to create a lot of FC connections between hosts and the storage system. This would in turn require a large number of FC Initiators, each of which having a unique World-Wide Port Name (WWPN).. The easiest and cheapest method to set up a lot of initiators without actually purchasing zillions of FC HBAs would be to use N_Port ID Virtualization, a.k.a. NPIV. This method allows a single FC HBA to present itself to the FC fabric with multiple WWPNs. This, in turn, allows the creation of many connections to the target storage device from a small number of hosts.. ...
Clear differences in the number and nature of GH proteins secreted by S4F8 and Rut C30 were evident, with S4F8 expressing a larger range of GH families (32 versus 24 GH families in S4F8 and Rut C30, respectively), and more protein representatives per GH family (Figure 3). More proteins belonging to GH families 3 (β-glucosidase/β-xylosidase), 5 (various), 11 (endoxylanase), 16 (transglycosylase and glucanosyltransferase), 28 (polygalacturonase), 31 (α-glucosidase/α-xylosidase), 62 (α-L/N-arabinofuranosidase), 72 (glucanosyltransglycosylase) and 92 (mannosidase) were detected for S4F8. Representatives of GH families 10 (endoxylanase), 12 (endoglucanase), 15 (starch-related), 17 (glucan 1,3-β-glucosidase), 18 (chitinase), 43 (xylosidase), 47 (α-mannosidase), 79 (glucoronidase), 93 (exo-arabinase) and 95 (fucosidase) were unique to S4F8, whereas only representatives of GH families 30 (β-glucocerebrosidase) and 61 (endoglucanases, recently reclassified as copper-dependent lytic monooxygenases ...
Beta Galactosidase | Learn more about Beta Galactosidase | Meaning of Beta Galactosidase | Description of Beta Galactosidase | Details of Beta Galactosidase | Article on Beta Galactosidase | Essay on Beta Galactosidase | Definition of Beta Galactosidase | Infospaze
The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.
Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
High purity 4 Methylumbelliferyl beta Xylobioside for use in research biochemical enzyme assays and in vitro diagnostic analysis Purchase
Page contains details about β-galactosidase/ZIF-8 MOF coating . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
This 3.5-inch enterprise hard disk has been selected by enterprise market leaders for it`s ability to satisfy storage demands unlike any other technology in storage indusrty. "Cloud-based data center storage needs are expanding faster than many current infrastructures can sustain, rendering the capacity demands of users a herculean task for cloud managers," said Mark Re, senior VP and CTO, Seagate. "Built on our years of R&D of sealed-drive technology, our new helium-based enterprise drive is designed precisely to help data-centric organizations worldwide solve the needs of their growing storage business.". "With the amount of data today growing at an increasingly rapid rate, we are always on the lookout for storage solutions that offer better performance with lower overhead," said Fan Ruiqi, president of storage products, Huawei Technologies Co., Ltd. "The new Enterprise Capacity 3.5 HDD from Seagate helps us meet these demands by offering incredible capacity with improvements in power and ...
Tesla product unveiling on the 17th (unexpected by most)," Musk tweeted on Sunday. The cryptic language was enough to prompt speculation while simultaneously leaving investors pretty much clueless. (Thanks a lot, Elon.). Fortunately, Musk did rule out one announcement when he tweeted that the event would be "followed by Tesla/SolarCity on the 28th." This statement referenced a previous tweet in September noting the company was "aiming" to reveal its new solar roof, with an integrated second-generation energy storage product and a "Tesla charger," on Oct. 28. Its not clear whether this Oct. 28 product announcement is contingent on the closing of its acquisition attempt of solar panel company SolarCity -- a deal Tesla hopes to close in the fourth quarter of 2016. But it looks like Tesla is continuing to plan on the event even as the two companies remain separate. ...
[124 Pages Report] Check for Discount on United States Bifidiobacterium Bifidum Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Bifidiobacterium Bifidum Revenue,...
gp120 is a subunit of the envelope glycoprotein of HIV-1. The third variable loop region of gp120 (V3 loop) contains multiple immunodominant epitopes and is also functionally important for deciding cell-tropism of the virus. 447-52D is a monoclonal antibody that recognizes the conserved tip of the V3 loop in a β-turn conformation. This antibody has previously been shown to neutralize diverse strains of the virus. In an attempt to generate an immunogen competent to generate 447-52D-like antibodies, the known epitope of 447-52D was inserted at three different surface loop locations in the small, stable protein Escherichia coli Trx (thioredoxin). At one of the three locations (between residues 74 and 75), the insertion was tolerated, the resulting protein was stable and soluble, and bound 447-52D with an affinity similar to that of intact gp120. Upon immunization, the V3 peptide-inserted Trx scaffold was able to generate anti-V3 antibodies that could compete out 447-52D binding to gp120. Epitope ...
consist of a backbone of (1→3)- and/or (1→4)-linked α-L-fucopyranose residues that may be substituted with sulfate (SO3-) on C-2, C-3, or C-4 and acetyl groups at C-4 on the main chain or may have short fucoside side chains that are usually linked from the O-4 of one or several of the fucopyranose backbone residues. FCSPs are known to exhibit crucial biological activities including anti-tumor activity. Although differently extracted, purified, fucose-rich, modified fucoidans have been reported to exert bioactive properties such as anti-coagulant and enhance immune response activity, few studies have investigated the bioactivity of unfractionated FCSPs, notably FCSPs extracted using milder and fewer processing steps. Crude fucoidan from Sargassum sp. and Fucus vesiculosus were examined for their bioactivity against lung and skin cancer cell lines in both in vitro and in vivo studies. This study showed that unfractionated FCSPs hinder the in vitro proliferation of Lewis lung carcinoma and ...
Matsushima, R., Kondo, M., Nishimura, M. and Hara-Nishimura, I. (2003), A novel ER-derived compartment, the ER body, selectively accumulates a β-glucosidase with an ER-retention signal in Arabidopsis. The Plant Journal, 33: 493-502. doi: 10.1046/j.1365-313X.2003.01636.x ...
Page contains details about β-galactosidase expressing plasmid encapsulating liposomes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Alpha-complementation of β-galactosidase does not seem to yield activities equal to wildtype β-galactosidase. Depending on the fragment, the activity can be up to 24% of wildtype [5]. (If anyone has a better reference comparing results from a Miller assay of alpha-complementated β-galactosidase with wildtype, please include it here.) ...
Comments in order of generation, not importance: "This is a port of boost.uuid from the boost project with some minor additions and API changes for a more D-like API." shouldnt be the first line in the docs. "A UUID, or Universally unique identifier," one of these (or both) should link to the Wikipedia article. Variant is the name of an existing Phobos library type and version is a D keyword. Now, thanks to Wikipedia I understand that variants and versions are a core part of UUIDs, but a lack of documentation explanation sent me for a loop. These terms should be explained better. Suggested rewrite: "This library implements a UUID as a struct allowing a UUID to be used in the most efficient ways, including using memcpy. A drawback is that a struct can not have a default constructors, and thus simply declaring a UUID will not initialize it to a value generated by one of the defined mechanisms. Use the structs constructors or the UUID generator functions to get an initialized UUID."-, "For ...
A protocol for high-throughput quantitation of β-galactosidase expression in mammalian cells. Quantitation of β-galactosidase expression is accomplished by batch processing of 96- and 384-well plates.

Fucosidosis: genetic and biochemical analysis of eight cases. | Journal of Medical GeneticsFucosidosis: genetic and biochemical analysis of eight cases. | Journal of Medical Genetics

... had a partial deficiency of alpha-L-fucosidase in her fibroblasts and leucocytes at a young age but normal alpha-L-fucosidase ... The basis of her transient deficiency of alpha-L-fucosidase is not known. The detection of five novel mutations in six severely ... The molecular basis of the deficiency of alpha-L-fucosidase has been investigated in eight patients who had been diagnosed ... None of the patients had a deletion or gross alteration of the alpha-L-fucosidase gene (FUCA1). Single strand conformation ...
more infohttp://jmg.bmj.com/content/34/2/105

Alpha-fucosidase | definition of alpha-fucosidase by Medical dictionaryAlpha-fucosidase | definition of alpha-fucosidase by Medical dictionary

... alpha-fucosidase explanation free. What is alpha-fucosidase? Meaning of alpha-fucosidase medical term. What does alpha- ... Looking for online definition of alpha-fucosidase in the Medical Dictionary? ... Alpha-fucosidase , definition of alpha-fucosidase by Medical dictionary https://medical-dictionary.thefreedictionary.com/alpha- ... medical-dictionary.thefreedictionary.com/alpha-fucosidase,alpha-fucosidase,/a,. *Facebook ...
more infohttp://medical-dictionary.thefreedictionary.com/alpha-fucosidase

Sequence Similarity 









- 1HL8: CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE Sequence Similarity Report PageSequence Similarity - 1HL8: CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE Sequence Similarity Report Page

Crystal Structure of Thermotoga Maritima Alpha-L-Fucosidase. Insights Into the Catalytic Mechanism and the Molecular Basis for ... Alpha-L-fucosidase, putative 2336 3.2.1.51 , Details 4 1HL9 1 A, B PUTATIVE ALPHA-L-FUCOSIDASE ORF TM0306 2336 3.2.1.51 , ... Alpha-L-fucosidase, putative 2336 3.2.1.51 , Details 7 1HL8 1 A, B PUTATIVE ALPHA-L-FUCOSIDASE ORF TM0306 2336 3.2.1.51 , ... ALPHA-L-FUCOSIDASE, PUTATIVE 2336 3.2.1.51 , Details 14 1ODU 1 A, B PUTATIVE ALPHA-L-FUCOSIDASE ORF TM0306 2336 3.2.1.51 , ...
more infohttp://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1HL8&entity=1&seqid=95

Alpha-fucosidase elisa and antibodyAlpha-fucosidase elisa and antibody

Recombinant Protein and Alpha-fucosidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are ... Alpha-fucosidase A. Alpha-fucosidase A ELISA Kit. Alpha-fucosidase A Recombinant. Alpha-fucosidase A Antibody. Also known as ... Alpha-fucosidase A (Alpha-L-fucoside fucohydrolase A).. Alpha-fucosidase involved in degradation of fucosylated xyloglucans. ... Alpha-fucosidase involved in degradation of fucosylated xyloglucans. Hydrolyzes alpha-1,2-linked fucose. Active on cotton ...
more infohttps://www.mybiosource.com/protein_family.php?root=alpha-fucosidase

Probable alpha-fucosidase elisa and antibodyProbable alpha-fucosidase elisa and antibody

Recombinant Protein and Probable alpha-fucosidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Probable alpha-fucosidase A. Probable alpha-fucosidase A ELISA Kit. Probable alpha-fucosidase A Recombinant. Probable alpha- ... fucosidase A Antibody. Also known as Probable alpha-fucosidase A (Alpha-L-fucoside fucohydrolase A).. Alpha-fucosidase involved ... Hydrolyzes alpha-1,2-linked fucose (By similarity).. Below are the list of possible Probable alpha-fucosidase products. If you ...
more infohttps://www.mybiosource.com/protein_family.php?root=probable-alpha-fucosidase

Sequence Similarity 









- 1HL9: CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE IN COMPLEX WITH A MECHANISM...Sequence Similarity - 1HL9: CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE IN COMPLEX WITH A MECHANISM...

L-Fucosidase: Insights Into the Catalytic Mechanism and the Molecular Basis for Fucosidosis ... PUTATIVE ALPHA-L-FUCOSIDASE protein, length: 449 (BLAST) Sequence Similarity Cutoff. Rank. Chains in Cluster. Cluster ID / Name ... CRYSTAL STRUCTURE OF THERMOTOGA MARITIMA ALPHA-FUCOSIDASE IN COMPLEX WITH A MECHANISM BASED INHIBITOR. ...
more infohttp://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1HL9

Alpha-L-fucosidase - WikipediaAlpha-L-fucosidase - Wikipedia

1,2-alpha-L-fucosidase 1,3-alpha-L-fucosidase 1,6-alpha-L-fucosidase FUCA2 Endreffy I, Bjørklund G, Szerafin L, Urbina MA, ... In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction an alpha-L-fucoside + H2O ... The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This ... doi: 10.1007/s12026-017-8943-x. Levvy GA, Mcallan A (August 1961). "Mammalian fucosidases. 2. alpha-L-Fucosidase". The ...
more infohttps://en.wikipedia.org/wiki/Alpha-L-fucosidase

1,2-alpha-L-fucosidase - Wikipedia1,2-alpha-L-fucosidase - Wikipedia

In enzymology, a 1,2-alpha-L-fucosidase (EC 3.2.1.63) is an enzyme that catalyzes the chemical reaction methyl-2-alpha-L- ... Other names in common use include almond emulsin fucosidase, and alpha-(1->2)-L-fucosidase. As of late 2007, 4 structures have ... 2-alpha-L-fucosidase". J. Biol. Chem. 245 (2): 299-304. PMID 5460888. Ogata-Arakawa M, Muramatsu T, Kobata A (1977). "alpha-L- ... Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66 (2): 379-87. doi:10.1111/j.1432 ...
more infohttps://en.wikipedia.org/wiki/1,2-alpha-L-fucosidase

Human Metabolome Database: Showing Protein Plasma alpha-L-fucosidase (HMDBP00876)Human Metabolome Database: Showing Protein Plasma alpha-L-fucosidase (HMDBP00876)

Involved in alpha-L-fucosidase activity. Specific Function. Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6- ... Showing Protein Plasma alpha-L-fucosidase (HMDBP00876). IdentificationBiological propertiesGene propertiesProtein properties ...
more infohttp://www.hmdb.ca/proteins/HMDBP00876

Identifying the Catalytic Acid/Base in GH29 alpha-L-Fucosidase Subfamilies | UBC ChemistryIdentifying the Catalytic Acid/Base in GH29 alpha-L-Fucosidase Subfamilies | UBC Chemistry

While the catalytic nucleophile in the configuration-retaining alpha-L-fucosidases from family GH29 is fully conserved with ... we largely confirm the acid/base residue predictions for the GH29 fucosidases from the two subfamilies. ...
more infohttps://www.chem.ubc.ca/identifying-catalytic-acidbase-gh29-alpha-l-fucosidase-subfamilies

Anti-alpha-L-Fucosidase, 01-20151  | ARP American Research Products, Inc.Anti-alpha-L-Fucosidase, 01-20151 | ARP American Research Products, Inc.

Rat monoclonal Antibody to alpha-L-Fucosidase. Clone. ALF89. Immunogen. Alpha-L-Fucosidase from human liver (51 kDa & 56 kDa ...
more infohttps://www.arp1.com/products/antibodies/monoclonal-antibodies/anti-alpha-l-fucosidase.html

An anthracenecarboximide fluorescent probe for in vitro and in vivo ratiometric imaging of endogenous alpha-l-fucosidase for...An anthracenecarboximide fluorescent probe for in vitro and in vivo ratiometric imaging of endogenous alpha-l-fucosidase for...

Herein, a ratiometric fluorescent probe for the alpha-l-fucosidase (AFU) assay based on a single fluorophore has been developed ... Alpha-l-fucosidase (AFU) plays vital roles in some physiological processes that closely relate to several diseases. ... Alpha-L-fucosidase (AFU) plays vital roles in some physiological processes that closely relate to several diseases. Herein, a ... An anthracenecarboximide fluorescent probe for in vitro and in vivo ratiometric imaging of endogenous alpha-L-fucosidase for ...
more infohttp://pubs.rsc.org/en/content/articlelanding/2017/qm/c6qm00112b

AID 488425 - Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at 1000 uM at pH 5.5 by...AID 488425 - Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at 1000 uM at pH 5.5 by...

Inhibition of bovine epididymis alpha-L-fucosidase assessed as p-nitrophenol release at 1000 uM at pH 5.5 by spectrometric ...
more infohttps://pubchem.ncbi.nlm.nih.gov/bioassay/488425

PDF] Alteration of the isoform composition of plasma-membrane-associated rat sperm alpha-L-fucosidase during late epididymal...PDF] Alteration of the isoform composition of plasma-membrane-associated rat sperm alpha-L-fucosidase during late epididymal...

... rat sperm alpha-L-fucosidase was characterized during epididymal maturation. The pH 7 activity optimum of alpha-L-fucosidase ... alpha-L-Fucosidase from sperm from the distal half of the cauda, which contained a significant enrichment of sperm and alpha-L- ... Isoelectric focusing of alpha-L-fucosidase indicated the presence of a major isoform (B) with a pI near 7 in sperm from testis ... Neuraminidase treatment of sperm alpha-L-fucosidase from distal cauda (when compared with the appropriate heat-treated control ...
more infohttps://www.semanticscholar.org/paper/Alteration-of-the-isoform-composition-of-rat-sperm-Abascal-Skalaban/a556f77fd3588e5ca354abb4d40fa9f7a9f551f6

Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase ...Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase ...

2-alpha-l-fucosidase (AfcA) was isolated. The afcA gene was found to comprise 1,959 amino acid residues with a predicted ... A domain responsible for fucosidase activity (the Fuc domain; amino acid residues 577 to 1474) was localized by deletion ... The recombinant Fuc domain specifically hydrolyzed the terminal alpha-(1--,2)-fucosidic linkages of various oligosaccharides ... genomic library of Bifidobacterium bifidum constructed in Escherichia coli was screened for the ability to hydrolyze the alpha ...
more infohttps://www.semanticscholar.org/paper/Molecular-cloning-and-characterization-of-bifidum-a-Katayama-Sakuma/91e9df349be585a3b4ce31976835cb73edcf8763

1 3 alpha l fucosidase : définition de 1 3 alpha l fucosidase et synonymes de 1 3 alpha l fucosidase (anglais)1 3 alpha l fucosidase : définition de 1 3 alpha l fucosidase et synonymes de 1 3 alpha l fucosidase (anglais)

... dérivés de 1 3 alpha l fucosidase, dictionnaire analogique de 1 3 alpha l fucosidase (anglais) ... In enzymology, a 1,3-alpha-L-fucosidase (EC 3.2.1.111) is an enzyme that catalyzes the chemical reaction of cleaving the 1,3- ... 1,3-alpha-L-fucosidase. From Wikipedia, the free encyclopedia. Jump to: navigation, search ... Ogata-Arakawa M, Muramatsu T, Kobata A (1977). [Expression error: Missing operand for , "alpha-L-fucosidases from almond ...
more infohttp://dictionnaire.sensagent.leparisien.fr/1+3+alpha+l+fucosidase/en-en/

Alpha- l -Fucosidase Isoenzyme iso2 from Paenibacillus thiaminolyticus | BMC Biotechnology | Full TextAlpha- l -Fucosidase Isoenzyme iso2 from Paenibacillus thiaminolyticus | BMC Biotechnology | Full Text

Activity-based screening of a genomic library was used to isolate the gene encoding a novel α-L-fucosidase. The enzyme was ... As a very low amino acid sequence similarity with known α-l-fucosidases was found, following study could be important for ... In this study, new enzyme α-l-fucosidase iso2 originating from Paenibacillus thiaminolyticus was described and prepared in ... Hydrolytic and transglycosylation abilities of α-l-fucosidase iso2 were tested using different acceptor molecules. ...
more infohttps://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-015-0160-x

First trimester prenatal diagnosis of lysosomal storage disease. Study of alpha-L-fucosidase isoenzyme patterns in fetal and...First trimester prenatal diagnosis of lysosomal storage disease. Study of alpha-L-fucosidase isoenzyme patterns in fetal and...

Study of alpha-L-fucosidase isoenzyme patterns in fetal and maternal tissue.. dc.contributor.author. Lissens, W. ... For the sixth enzyme, alpha-L-fucosidase, where on occasion very low activities were found, the results obtained on fresh ... Study of alpha-L-fucosidase isoenzyme patterns in fetal and maternal tissue.. en. ... Differences in the isoenzyme pattern of alpha-L-fucosidase were found in chorionic villi and maternal decidua. Although further ...
more infohttp://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/40607?show=full

ATFXG1 - PrimePCR Assay and Template | Life Science | Bio-RadATFXG1 - PrimePCR Assay and Template | Life Science | Bio-Rad

Alpha-fucosidase 1 Assay Type: SYBR® Green Assay Design: Exonic Application: Gene Expression Unique Assay ID: qAthCED0040680 ... Alpha-fucosidase 1 Assay Type: Probe Assay Design: Exonic Application: Gene Expression Unique Assay ID: qAthCEP0013522 FAM HEX ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/atfxg1-arabidopsis

Fucosidosis
     Summary Report | CureHunterFucosidosis Summary Report | CureHunter

An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an ... alpha Fucosidase Deficiency Disease; alpha L Fucosidase Deficiency Disease; alpha-Fucosidase Deficiency Diseases; alpha-L- ... alpha-L-Fucosidase; Disease, Fucosidase Deficiency; Disease, alpha-Fucosidase Deficiency; Disease, alpha-L-Fucosidase ... alpha-Fucosidase Deficiency Disease; alpha-L-Fucosidase Deficiency; alpha-L-Fucosidase Deficiency Disease; 1, Fucosidosis Type ...
more infohttp://www.curehunter.com/public/keywordSummaryD005645-Fucosidosis.do

FUCA1 gene - Genetics Home Reference - NIHFUCA1 gene - Genetics Home Reference - NIH

OMIM: FUCOSIDASE, ALPHA-L, 1. *. Willems PJ, Gatti R, Darby JK, Romeo G, Durand P, Dumon JE, OBrien JS. Fucosidosis revisited ... alpha-L-fucosidase 1. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... The FUCA1 gene provides instructions for making an enzyme called alpha-L-fucosidase. This enzyme is found in lysosomes, which ... Most of these mutations result in an abnormally short, nonfunctional alpha-L-fucosidase enzyme. Without this enzyme, ...
more infohttps://ghr.nlm.nih.gov/gene/FUCA1

FUCA2 Gene - GeneCards | FUCO2 Protein | FUCO2 AntibodyFUCA2 Gene - GeneCards | FUCO2 Protein | FUCO2 Antibody

Alpha-L-Fucosidase 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of ... Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of ... This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=FUCA2

IJMS  | Free Full-Text | Exploring the Glycosylation of Serum CA125 | HTMLIJMS | Free Full-Text | Exploring the Glycosylation of Serum CA125 | HTML

BKF-bovine kidney alpha-fucosidase (EC 3.2.1.51), 1 U/mL; GUH-β-N-acetylglucosaminidase cloned from Streptococcus pneumonia, ... Monitoring core-fucosylation levels in alpha-fetoprotein is a sensitive marker for early tumour detection [40]. In early stage ...
more infohttp://www.mdpi.com/1422-0067/14/8/15636/htm

FUCA1 Gene - GeneCards | FUCO Protein | FUCO AntibodyFUCA1 Gene - GeneCards | FUCO Protein | FUCO Antibody

Alpha-L- 1, Tissue, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... R&D Systems Antibodies for FUCA1 (Tissue alpha-L-Fucosidase/FUCA1). *R&D Systems Proteins and Enzymes for FUCA1 (Tissue alpha-L ... Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of ... Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=FUCA1
  • α- l -Fucosidases (3.2.1.51) are glycosidases that are able to cleave terminal α- l -fucosyl moiety from different types of oligosaccharides and glycoconjugates. (biomedcentral.com)
  • Using a genomic library of Paenibacillus thiaminolyticus , constructed in E.coli DH5α cells, nucleotide sequence of a new α- l -fucosidase isoenzyme was determined and submitted to the EMBL database (HE654122). (biomedcentral.com)
  • Differences in the isoenzyme pattern of alpha-L-fucosidase were found in chorionic villi and maternal decidua. (ac.ke)
  • It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children. (wikipedia.org)
  • α- l -Fucosidases are enzymes involved in metabolism of α- l -fucosylated molecules, compounds with a fundamental role in different life essential processes including immune response, fertilization and development, but also in some serious pathological events. (biomedcentral.com)
  • α- l -Fucosidases catalyzing transglycosylation reactions might be interesting in synthesis of α- l -fucosylated molecules with potential application especially in pharmaceutical industry, as these molecules are involved in many life-important or life-threatening processes in eukaryotic organisms. (biomedcentral.com)
  • Alpha- L -fucosidase (AFU) plays vital roles in some physiological processes that closely relate to several diseases. (rsc.org)
  • Stabilization of membrane-associated alpha-L-fucosidase by the human sperm equatorial segment. (semanticscholar.org)
  • Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. (semanticscholar.org)
  • Through comparison of kinetic parameters obtained for the hydrolysis of fucosyl substrates with activated leaving groups by these mutants with those of the corresponding wild-type enzymes, in conjunction with the demonstration of azide rescue, we largely confirm the acid/base residue predictions for the GH29 fucosidases from the two subfamilies. (ubc.ca)
  • For the sixth enzyme, alpha-L-fucosidase, where on occasion very low activities were found, the results obtained on fresh chorionic villi have to be interpreted with extreme caution. (ac.ke)
  • Below are the list of possible Alpha-fucosidase products. (mybiosource.com)
  • This project aimed to discover and analyze the molecular mechanism of synthesis of two particular fucosylated oligosaccharide products in a mutant enzyme, Thermatoga maratima Alpha-L-Fucosidase D224G, whose wild type performs the opposite reaction (cleavage of fucosyl glycosidic bonds). (umich.edu)
  • While the catalytic nucleophile in the configuration-retaining alpha-L-fucosidases from family GH29 is fully conserved with respect to sequence, there is no fully sequence-conserved acid/base residue candidate across the family. (ubc.ca)
  • Identification of the catalytic nucleophile of the family 29 alpha-L-fucosidase from Sulfolobus solfataricus via chemical rescue of an inactive mutant. (semanticscholar.org)
  • In the present study, rat sperm alpha-L-fucosidase was characterized during epididymal maturation. (semanticscholar.org)
  • In this study, new enzyme α- l -fucosidase iso2 originating from Paenibacillus thiaminolyticus was described and prepared in recombinant form and its hydrolytic and transglycosylation properties were characterized. (biomedcentral.com)