AnatomyOrganismsChemicals and DrugsPhenomena and ProcessesInformation Science
alpha KaryopherinsKaryopherinsbeta KaryopherinsNuclear PoreActive Transport, Cell Nucleusran GTP-Binding ProteinNuclear Pore Complex ProteinsNuclear Localization SignalsCell NucleusSaccharomyces cerevisiae ProteinsNuclear ProteinsSaccharomyces cerevisiaeReceptors, Cytoplasmic and NuclearProtein Bindingalpha 1-AntitrypsinReceptors, Adrenergic, alphaHypoxia-Inducible Factor 1, alpha Subunitalpha7 Nicotinic Acetylcholine ReceptorIntegrin alpha3beta1Integrin alpha4Integrin alpha6Integrin alpha5beta1Integrin alpha4beta1Interleukin-1alphaIntegrin alpha2beta1Receptors, Adrenergic, alpha-1Integrin alpha5Integrin alpha1beta1NucleoplasminsDatabases, ProteinInternetUser-Computer InterfaceAuthorshipKnowledge BasesDictionaries, MedicalDictionaries as TopicRats, Inbred BUFGTP-Binding Proteins
alpha Karyopherins
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Karyopherins
A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process.
beta Karyopherins
Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
Nuclear Pore
An opening through the NUCLEAR ENVELOPE formed by the nuclear pore complex which transports nuclear proteins or RNA into or out of the CELL NUCLEUS and which, under some conditions, acts as an ion channel.
Active Transport, Cell Nucleus
Gated transport mechanisms by which proteins or RNA are moved across the NUCLEAR MEMBRANE.
ran GTP-Binding Protein
A monomeric GTP-binding protein involved in nucleocytoplasmic transport of proteins into the nucleus and RNA into the cytoplasm. This enzyme was formerly listed as EC 3.6.1.47.
Nuclear Pore Complex Proteins
Proteins that form the structure of the NUCLEAR PORE. They are involved in active, facilitated and passive transport of molecules in and out of the CELL NUCLEUS.
Nuclear Localization Signals
Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Saccharomyces cerevisiae Proteins
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Nuclear Proteins
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Saccharomyces cerevisiae
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
alpha 1-Antitrypsin
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
alpha7 Nicotinic Acetylcholine Receptor
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Integrin alpha3beta1
Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.
Integrin alpha4
An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.
Integrin alpha6
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
Integrin alpha5beta1
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Interleukin-1alpha
An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
Integrin alpha2beta1
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Receptors, Adrenergic, alpha-1
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
Integrin alpha5
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Nucleoplasmins
A family of histone molecular chaperones that play roles in sperm CHROMATIN decondensation and CHROMATIN ASSEMBLY in fertilized eggs. They were originally discovered in XENOPUS egg extracts as histone-binding factors that mediate nucleosome formation in vitro.
Databases, Protein
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
User-Computer Interface
The portion of an interactive computer program that issues messages to and receives commands from a user.
Authorship
The profession of writing. Also the identity of the writer as the creator of a literary production.
Knowledge Bases
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Rats, Inbred BUF
GTP-Binding Proteins
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.

Phosphorylation-dependent binding of hepatitis B virus core particles to the nuclear pore complex. (1/392)

Although many viruses replicate in the nucleus, little is known about the processes involved in the nuclear import of viral genomes. We show here that in vitro generated core particles of human hepatitis B virus bind to nuclear pore complexes (NPCs) in digitonin-permeabilized mammalian cells. This only occurred if the cores contained phosphorylated core proteins. Binding was inhibited by wheat germ agglutinin, by antinuclear pore complex antibodies, and by peptides corresponding either to classical nuclear localization signals (NLS) or to COOH-terminal sequences of the core protein. Binding was dependent on the nuclear transport factors importins (karyopherins) alpha and beta. The results suggested that phosphorylation induces exposure of NLS in the COOH-terminal portion of the core protein that allows core binding to the NPCs by the importin- (karyopherin-) mediated pathway. Thus, phosphorylation of the core protein emerged as an important step in the viral replication cycle necessary for transport of the viral genome to the nucleus.  (+info)

Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. (2/392)

The erythroid membrane cytoskeletal protein 4.1 is the prototypical member of a genetically and topologically complex family that is generated by combinatorial alternative splicing pathways and is localized at diverse intracellular sites including the nucleus. To explore the molecular determinants for nuclear localization, we transfected COS-7 cells with epitope-tagged versions of natural red cell protein 4.1 (4.1R) isoforms as well as mutagenized and truncated derivatives. Two distant topological sorting signals were required for efficient nuclear import of the 4.1R80 isoform: a basic peptide, KKKRER, encoded by alternative exon 16 and acting as a weak core nuclear localization signal (4.1R NLS), and an acidic peptide, EED, encoded by alternative exon 5. 4.1R80 isoforms lacking either of these two exons showed decreased nuclear import. Fusion of various 4.1R80 constructs to the cytoplasmic reporter protein pyruvate kinase confirmed a requirement for both motifs for full NLS function. 4.1R80 was efficiently imported in the nuclei of digitonin-permeabilized COS-7 cells in the presence of recombinant Rch1 (human importin alpha2), importin beta, and GTPase Ran. Quantitative analysis of protein-protein interactions using a resonant mirror detection technique showed that 4.1R80 bound to Rch1 in vitro with high affinity (KD = 30 nM). The affinity decreased at least 7- and 20-fold, respectively, if the EED motif in exon 5 or if 4.1R NLS in exon 16 was lacking or mutated, confirming that both motifs were required for efficient importin-mediated nuclear import of 4.1R80.  (+info)

Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences. (3/392)

Although much is known about the mechanisms of signal-mediated protein and RNA nuclear import and export, little is understood concerning the nuclear import of plasmid DNA. Plasmids between 4.2 and 14.4 kilobases were specifically labeled using a fluorescein-conjugated peptide nucleic acid clamp. The resulting substrates were capable of gene expression and nuclear localization in microinjected cells in the absence of cell division. To elucidate the requirements for plasmid nuclear import, a digitonin-permeabilized cell system was adapted to follow the nuclear localization of plasmids. Nuclear import of labeled plasmid was time- and energy-dependent, was inhibited by the lectin wheat germ agglutinin, and showed an absolute requirement for cytoplasmic extract. Addition of nuclear extract alone did not support plasmid nuclear import but in combination with cytoplasm stimulated plasmid nuclear localization. Whereas addition of purified importin alpha, importin beta, and RAN was sufficient to support protein nuclear import, plasmid nuclear import also required the addition of nuclear extract. Finally, nuclear import of plasmid DNA was sequence-specific, requiring a region of the SV40 early promoter and enhancer. Taken together, these results confirm and extend our findings in microinjected cells and support a protein-mediated mechanism for plasmid nuclear import.  (+info)

Nuclear import of RPA in Xenopus egg extracts requires a novel protein XRIPalpha but not importin alpha. (4/392)

Replication protein A (RPA) is a eukaryotic single-stranded (ss) DNA-binding protein that is essential for general DNA metabolism. RPA consists of three subunits (70, 33 and 14 kDa). We have identified by two-hybrid screening a novel Xenopus protein called XRIPalpha that interacts with the ssDNA-binding domain of the largest subunit of RPA. XRIPalpha homologues are found in human and in Drosophila but not in yeast. XRIPalpha is complexed with RPA in Xenopus egg extracts together with another 90 kDa protein that was identified as importin beta. We have demonstrated that XRIPalpha, but not importin alpha, is required for nuclear import of RPA. Immunodepletion of XRIPalpha from the egg extracts blocks nuclear import of RPA but not that of nucleoplasmin, a classical import substrate. RPA import can be restored by addition of recombinant XRIPalpha. Conversely, depletion of importin alpha blocks import of nucleoplasmin but not that of RPA. GST-XRIPalpha pull-down assay shows that XRIPalpha interacts directly with recombinant importin beta as well as with RPA in vitro. Finally, RPA import can be reconstituted from the recombinant proteins. We propose that XRIPalpha plays the role of importin alpha in the RPA import scheme: XRIPalpha serves as an adaptor to link RPA to importin beta.  (+info)

The direction of transport through the nuclear pore can be inverted. (5/392)

Transport of macromolecules across the nuclear envelope is an active process that depends on soluble factors including the GTPase Ran. Ran-GTP is predominantly located in the nucleus and has been shown to regulate cargo binding and release of import and export receptors in their respective target compartments. Recently, it was shown that transport of receptor-cargo complexes across the nuclear pore complex (NPC) does not depend on GTP-hydrolysis by Ran; however, the mechanism of translocation is still poorly understood. Here, we show that the direction of transport through the NPC can be inverted in the presence of high concentrations of cytoplasmic Ran-GTP. Under these conditions, two different classes of export cargoes are transported into the nucleus in the absence of GTP hydrolysis. The inverted transport is very rapid and can be blocked by known inhibitors of nuclear protein export. These results suggest that the NPC functions as a facilitated transport channel, allowing the selective translocation of receptor-cargo complexes. We conclude that the directionality of nucleocytoplasmic transport is determined mainly by the compartmentalized distribution of Ran-GTP.  (+info)

Cellular uptake and nuclear delivery of recombinant adenovirus penton base. (6/392)

An Ad2 capsid component, the penton base, expressed as recombinant protein, was found to be capable of affecting the entire entry pathway of adenovirion in HeLa cells, i.e., cell attachment, endocytosis, vesicular escape, intracytoplasmic movement, and translocation through the nuclear pore complex. Data with pentamerization-defective mutants suggested that none of these successive steps depended upon penton base pentamer status, indicating that the peptide domains responsible for these functions were carried by the monomer. Observations performed with wild-type (WT) and an integrin-binding-site double-mutant (K288E340) suggested that the penton base could enter the cell via an alternative, RGD- and LDV-independent, pathway. Of three mutants that were found to be defective in nuclear addressing in insect cells, only one, W165H, was also altered in nuclear transport in HeLa cells. The other two, W119H and RRR547EQQ, showed a WT pattern of nuclear localization in HeLa cells, suggesting that the region including tryptophan-119 and the basic signal at position 547 did not act as a nuclear localization signal in the human cell context. The integrity of cellular structures and the cytoskeleton seemed to be required for the vectorial movement and nuclear import of WT penton base, as suggested by experiments using permeabilized HeLa cells, isolated nuclear membranes, and cytoskeleton-targeted drugs.  (+info)

The yeast nucleoporin Nup2p is involved in nuclear export of importin alpha/Srp1p. (7/392)

The importin alpha.beta heterodimer mediates nuclear import of proteins containing classical nuclear localization signals. After carrying its cargo into the nucleus, the importin dimer dissociates, and Srp1p (the yeast importin alpha subunit) is recycled to the cytoplasm in a complex with Cse1p and RanGTP. Nup2p is a yeast FXFG nucleoporin that contains a Ran-binding domain. We find that export of Srp1p from the nucleus is impaired in Deltanup2 mutants. Also, Srp1p fusion proteins accumulate at the nuclear rim in wild-type cells but accumulate in the nuclear interior in Deltanup2 cells. A deletion of NUP2 shows genetic interactions with mutants in SRP1 and PRP20, which encodes the Ran nucleotide exchange factor. Srp1p binds directly to an N-terminal domain of Nup2p. This region of Nup2p is sufficient to allow accumulation of an Srp1p fusion protein at the nuclear rim, but the C-terminal Ran-binding domain of Nup2p is required for efficient Srp1p export. Formation of the Srp1p.Cse1p. RanGTP export complex releases Srp1p from its binding site in Nup2p. We propose that Nup2p may act as a scaffold that facilitates formation of the Srp1p export complex.  (+info)

A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. (8/392)

Abnormal p53 cellular localization has been considered to be one of the mechanisms that could inactivate p53 function. To understand the regulation of p53 cellular trafficking, we have previously identified two p53 domains involved in its localization. A basic domain, Lys(305)-Arg(306), is required for p53 nuclear import, and a carboxyl-terminal domain, namely the cytoplasmic sequestration domain (CSD) from residues 326-355, could block the nuclear import of Lys(305) or Arg(306) mutated p53. To characterize further the function of these two domains, we demonstrate in this report that the previously described major nuclear localization signal works together with Lys(305)-Arg(306) to form a bipartite and functional nuclear localization sequence (NLS) for p53 nuclear import. The CSD could block the binding of p53 to the NLS receptor, importin alpha, and reduce the efficiency of p53 nuclear import in MCF-7, H1299, and Saos-2 cells. The blocking effect of the CSD is not due to the enhancement of nuclear export or oligomerization of the p53. These results indicate that the CSD can regulate p53 nuclear import by controlling access of the NLS to importin alpha binding.  (+info)

Structural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20 - UQ eSpaceStructural characterisation of the nuclear import receptor importin alpha in complex with the bipartite NLS of Prp20 - UQ eSpace
The translocation of macromolecules into the nucleus is a fundamental eukaryotic process, regulating gene expression, cell division and differentiation, but which is impaired in a range of significant diseases including cancer and viral infection. The import of proteins into the nucleus is generally initiated by a specific, high affinity interaction between nuclear localisation signals (NLSs) and nuclear import receptors in the cytoplasm, and terminated through the disassembly of these complexes in the nucleus. For classical NLSs (cNLSs), this import is mediated by the importin-alpha (IMP alpha) adaptor protein, which in turn binds to IMP beta to mediate translocation of nuclear cargo across the nuclear envelope. The interaction and disassembly of import receptor: cargo complexes is reliant on the differential localisation of nucleotide bound Ran across the envelope, maintained in its low affinity, GDP-bound form in the cytoplasm, and its high affinity, GTP-bound form in the nucleus. This in ...
https://espace.library.uq.edu.au/view/UQ:320592
KPNA6 karyopherin subunit alpha 6 [Homo sapiens (human)] - Gene - NCBIKPNA6 karyopherin subunit alpha 6 [Homo sapiens (human)] - Gene - NCBI
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008 ...
https://www.ncbi.nlm.nih.gov/gene/23633
TCDB » SEARCHTCDB » SEARCH
1.I.1 The Eukaryotic Nuclear Pore Complex (E-NPC) Family [formerly 1.A.75]. Numerous NPC proteins, called nucleoporins, have been identified and characterized from vertebrates and yeast (Brohawn et al., 2009). Thirty such proteins are recognized constituents of the yeast NPC, and at least 50 nucleopore proteins have been characterized from vertebrates. Many of these proteins have been tabulated for (1) S. cerevisiae and (2) vertebrates by Stoffler et al. (1999) and Tran and Wente (2006). How they function in transport is poorly defined. It is known, however, that nuclear proteins contain short sequences called nuclear localization sequences (NLS) that target them for nuclear import. A nuclear localization sequence receptor and several cytosolic factors appear to play roles in nuclear import of NLS-bearing proteins. Nuclear export signals (NESs) have also been identified. Several different forms of each type of targeting signal have been identified that lack homology to each other and may be ...
http://tcdb.org/search/result.php?tc=1.I.1
Catalyst 3750 Switch Software Configuration Guide, 12.2(52)SE - Configuring HSRP [Cisco Catalyst 3750 Series Switches] - CiscoCatalyst 3750 Switch Software Configuration Guide, 12.2(52)SE - Configuring HSRP [Cisco Catalyst 3750 Series Switches] - Cisco
HSRP provides high network availability by providing redundancy for IP traffic from hosts on networks. In a group of router interfaces, the active router is the router of choice for routing packets; the standby router is the router that takes over the routing duties when an active router fails or when preset conditions are met. HSRP is useful for hosts that do not support a router discovery protocol and cannot switch to a new router when their selected router reloads or loses power. When HSRP is configured on a network segment, it provides a virtual MAC address and an IP address that is shared among router interfaces in a group of router interfaces running HSRP. The router selected by the protocol to be the active router receives and routes packets destined for the groups MAC address. For n routers running HSRP, there are n +1 IP and MAC addresses assigned. HSRP detects when the designated active router fails, and a selected standby router assumes control of the Hot Standby groups MAC and IP ...
https://www.cisco.com/c/en/us/td/docs/switches/lan/catalyst3750/software/release/12-2_52_se/configuration/guide/3750scg/swhsrp.html
KPNA4 / Importin alpha-4 antibody | acris-antibodies.comKPNA4 / Importin alpha-4 antibody | acris-antibodies.com
KPNA4 (karyopherin alpha 4), also known as importin alpha 3, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha…
https://www.acris-antibodies.com/target/kpna4-antibody-importin-alpha-4-antibody.htm
Yeast karyopherin Kap95 is required for cell cycle progression at Start | BMC Molecular and Cell Biology | Full TextYeast karyopherin Kap95 is required for cell cycle progression at Start | BMC Molecular and Cell Biology | Full Text
The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors of the β-karyopherin family. In this work we characterized the terminal phenotype of a mutant strain in β-karyopherin Kap95, a component of the classical nuclear import pathway. When KAP95 was inactivated, most cells arrested at the G2/M phase of the cell cycle, which is in agreement with the results observed in mutants in the other components of this pathway. However, a number of cells accumulate at G1, suggesting a novel role of Kap95 and the classical import pathway at Start. We investigated the localization of Start transcription factors. It is known that Swi6 contains a classical NLS that interacts with importin α. Here we show that the in vivo nuclear import of Swi6 depends on Kap95. For Swi4, we identified a functional NLS between amino acids 371 and 376
https://bmcmolcellbiol.biomedcentral.com/articles/10.1186/1471-2121-11-47
NP - Nucleoprotein - Influenza A virus (strain A/Wilson-Smith/1933 H1N1) - NP gene & proteinNP - Nucleoprotein - Influenza A virus (strain A/Wilson-Smith/1933 H1N1) - NP gene & protein
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoproteins nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoproteins
https://www.uniprot.org/uniprot/Q1K9H2
CSE1L chromosome segregation 1 like [Homo sapiens (human)] - Gene - NCBICSE1L chromosome segregation 1 like [Homo sapiens (human)] - Gene - NCBI
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012 ...
https://www.ncbi.nlm.nih.gov/gene/1434
Importin alpha 5/KPNA1/SRP1 Research Products: Novus BiologicalsImportin alpha 5/KPNA1/SRP1 Research Products: Novus Biologicals
Importin alpha 5/KPNA1/SRP1 products available through Novus Biologicals. Browse our Importin alpha 5/KPNA1/SRP1 product catalog backed by our Guarantee+.
https://www.novusbio.com/common-name/importin-alpha-5-kpna1-srp1
KPNA2 Antibody | scrazzl.com - Simply Connecting ScienceKPNA2 Antibody | scrazzl.com - Simply Connecting Science
importin-alpha-P1, importin alpha 1, IPOA1, karyopherin alpha 2 (RAG cohort 1, importin alpha 1), Karyopherin subunit alpha-2, pendulin, QIP2importin alpha 2, RAG cohort 1, RAG cohort protein 1, RCH1importin subunit alpha-2, SRP1, SRP1alpha, SRP1- ...
http://scrazzl.com/872500/kpna2-antibody
WikiGenes - KPNA4 - karyopherin alpha 4 (importin alpha 3)WikiGenes - KPNA4 - karyopherin alpha 4 (importin alpha 3)
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/gene/e/3840.html
PLOS ONE: Identification of Karyopherin α1 and α7 Interacting Proteins in Porcine TissuePLOS ONE: Identification of Karyopherin α1 and α7 Interacting Proteins in Porcine Tissue
Specialized trafficking systems in eukaryotic cells serve a critical role in partitioning intracellular proteins between the nucleus and cytoplasm. Cytoplasmic proteins (including chromatin remodeling enzymes and transcription factors) must gain access to the nucleus to exert their functions to properly program fundamental cellular events ranging from cell cycle progression to gene transcription. Knowing that nuclear import mediated by members of the karyopherin α family of transport receptors plays a critical role in regulating development and differentiation, we wanted to determine the identity of proteins that are trafficked by this karyopherin α pathway. To this end, we performed a GST pull-down assay using porcine orthologs of karyopherin α1 (KPNA1) and karyopherin α7 (KPNA7) and prey protein derived from porcine fibroblast cells and used a liquid chromatography and tandem mass spectrometry (LC-MS/MS) approach to determine the identity of KPNA1 and KPNA7 interacting proteins. Our screen
http://journals.plos.org/plosone/article/related?id=10.1371/journal.pone.0038990
Switch to Europe/Worldwide websiteSwitch to Europe/Worldwide website
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization sigl. The protein encoded…
https://www.acris-antibodies.com/target/ranbp7-antibody-importin-7-antibody.htm?donor_vector=RFP-BSD
Karyopherin (importin) beta 3 RNAi: Novus BiologicalsKaryopherin (importin) beta 3 RNAi: Novus Biologicals
Karyopherin (importin) beta 3 RNAi available through Novus Biologicals. Browse our Karyopherin (importin) beta 3 RNAi catalog backed by our Guarantee+.
https://www.novusbio.com/rnai/karyopherin-
OPUS Würzburg | SearchOPUS Würzburg | Search
Hey-mutant mouse hearts at embryonic day E14.5 were shown to react to the knock out of Hey2 with several up-regualted genes. This up-regulation is due to the lack of Hey2 and cannot be explained by the structural changes in heart morphology as shown using control animals. Part of the gene regulation was further validated using in situ hybridization. Hey1 was located to the nucleus in immunofluorescence experiments. However, experiments on protein level showed also amount of Hey1 within the cytoplasm. The nuclear localization of Hey1 was unchanged during all cell cycle phases as well as when CaMKII was co-expressed or other cellular pathways were inhibited or stimulated. Hey1 does not seem to interact with the nuclear transport proteins importin-alpha and -beta, therefore it still needs to be elucidated how Hey1 is transported into the nucleus ...
https://opus.bibliothek.uni-wuerzburg.de/solrsearch/index/search/searchtype/all/rows/10/institutefq/Theodor-Boveri-Institut+f%C3%BCr+Biowissenschaften/facetNumber_subject/all/sortfield/year/sortorder/asc/start/0/subjectfq/Herzentwicklung
Nuclear import substrates compete for a limited number of binding sites : evidence for different classes of yeast nuclear...Nuclear import substrates compete for a limited number of binding sites : evidence for different classes of yeast nuclear...
A nuclear receptor likely involved in nuclear protein import is described. Purified ATP-depleted yeast nuclei show saturable high-affinity binding of the yeast nuclear protein Mcm1. The dissociation constant for the binding is 0.5 microM, and the number of binding sites is approximately 3,500 per nucleus, equivalent to 10-30 binding sites per nuclear pore. Mcm1 competes with other yeast nuclear proteins Ste12 and Swi5, but not with Rap1 or Nop1, indicating that there may be different types of import receptors. Bound Mcm1 is resistant to extraction by nucleases, salt, and non-ionic detergent, but can be released by 5 M urea, suggesting that Mcm1 binds to a yeast equivalent of the nuclear pore complex-lamina fraction of higher eukaryotes ...
https://edoc.unibas.ch/2657/
anti-KPNA3 antibody, C-term | GeneTexanti-KPNA3 antibody, C-term | GeneTex
KPNA3 antibody, C-term (karyopherin alpha 3 (importin alpha 4)) for ICC/IF, IHC-P, IP, WB. Anti-KPNA3 pAb (GTX26038) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
http://www.genetex.com/KPNA3-IPOA4-antibody-C-term-GTX26038.html
Addgene: pCMVTNT-T7-KPNA2Addgene: pCMVTNT-T7-KPNA2
Plasmid pCMVTNT-T7-KPNA2 from Dr. Bryce Paschals lab contains the insert Karyopherin Alpha 2 and is published in BMC Cell Biol. 2010 . 11():63. This plasmid is available through Addgene.
http://www.addgene.org/26678/
Protein-analysis] What do you use for MSA and Design?Protein-analysis] What do you use for MSA and Design?
I am currently working on a computer user interface for specifying (not designing) mutational protein libraries. In addition to a online forms interface I would like to be able to directly import protein sequence data and multiple sequence alignments from a file. I was wondering whether any researchers would like to comment on what types of programs and data formats are popular. In paticular, I am considering an function to directly import Excel spreadsheet files (ala GoCore, etc.). Any comments would be greatly appreciated. Rick Colman UC Irvine ...
http://www.bio.net/bionet/mm/proteins/2006-July/011936.html
SSR3 - PCR Primer Pair - SYBR | PrimePCR | Bio-RadSSR3 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad
Gene Information The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha beta gamma and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit which is predicted to span the membrane four times. [provided by RefSeq Aug 2010]. ...
https://www.bio-rad.com/en-us/prime-pcr-assays/assay/qhsaced0043566-primepcr-sybr-green-assay-ssr3-human
KPNA6抗体(ab105350)| Abcam中国KPNA6抗体(ab105350)| Abcam中国
购买KPNA6兔多克隆抗体(ab105350)，KPNA6抗体经WB,ICC/IF验证，可与人,小鼠,大鼠样本反应。产品出库一年都在质保范围内。中国现货速达。
http://www.abcam.cn/kpna6-antibody-ab105350.html
KPNA2抗体- N-terminal|Abcam中国|Anti-KPNA2抗体- N-terminalKPNA2抗体- N-terminal|Abcam中国|Anti-KPNA2抗体- N-terminal
KPNA2兔多克隆抗体(ab82313)可与人样本反应并经WB, ELISA实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/kpna2-antibody-n-terminal-ab82313.html
Acetic Acid Market Growth Rate 2019 | Rising Trends, Demand Status and Growth Potential in Chemicals & Materials Sector...Acetic Acid Market Growth Rate 2019 | Rising Trends, Demand Status and Growth Potential in Chemicals & Materials Sector...
Report Titled: Acetic Acid Market - Growth, Trends, and Forecast (2019 - 2024). The Research Report on Acetic Acid Market 2019 report includes every aspect of the Acetic Acid industry along with the progress performance. Acetic Acid Market report presents an analysis of market size, share, and growth, trends, and price structure, statistical and detailed data of the Acetic Acid industry. Additionally, Acetic Acid Market 2019 research report offers key analysis on the industry status of the Acetic Acid producers with market size, growth, share, trends as well as business price structure.. The Acetic Acid Market report is a professional and detailed study on the Acetic Acid business. Acetic Acid market to predict future market directions between the forecast periods from 2019 to 2024 providing you with vital data for your business decisions.. Get a Sample Copy of the Report - https://www.industryresearch.co/enquiry/request-sample/14245773. Scope of the Report:. ...
https://bestmarketherald.com/2019/08/15/acetic-acid-market-growth-rate-2019-rising-trends-demand-status-and-growth-potential-in-chemicals-materials-sector-forecast-to-2024-2/
Karyopherin alpha 5 | definition of karyopherin alpha 5 by Medical dictionaryKaryopherin alpha 5 | definition of karyopherin alpha 5 by Medical dictionary
Looking for online definition of karyopherin alpha 5 in the Medical Dictionary? karyopherin alpha 5 explanation free. What is karyopherin alpha 5? Meaning of karyopherin alpha 5 medical term. What does karyopherin alpha 5 mean?
https://medical-dictionary.thefreedictionary.com/karyopherin+alpha+5
Significant Proportions of Nuclear Transport Proteins with Reduced Intracellular Mobilities Resolved by Fluorescence...Significant Proportions of Nuclear Transport Proteins with Reduced Intracellular Mobilities Resolved by Fluorescence...
TY - JOUR. T1 - Significant Proportions of Nuclear Transport Proteins with Reduced Intracellular Mobilities Resolved by Fluorescence Correlation Spectroscopy. AU - Paradise, Allison. AU - Levin, Mikhail K.. AU - Korza, George. AU - Carson, John H.. N1 - Funding Information: This work was supported by NIH grants NS15190, RR13186 and RR22232 (to J.H.C.). Initial FCS experiments on Ran protein in B104 cells were performed by students (Nancy Skoura, Cheryl Habrukowich, Matt Buckwalter) in the Biochemistry II course at UCHC (Farmington, CT). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2007/1/5. Y1 - 2007/1/5. N2 - Nuclear transport requires freely diffusing nuclear transport proteins to facilitate movement of cargo molecules through the nuclear pore. We analyzed dynamic properties of importin α, importin β, Ran and NTF2 in nucleus, cytoplasm and at the nuclear pore of neuroblastoma cells using fluorescence correlation spectroscopy. Mobile components were quantified by global ...
https://utsouthwestern.pure.elsevier.com/en/publications/significant-proportions-of-nuclear-transport-proteins-with-reduce
HSRP1 | definition of hSRP1 by Medical dictionaryHSRP1 | definition of hSRP1 by Medical dictionary
Looking for online definition of hSRP1 in the Medical Dictionary? hSRP1 explanation free. What is hSRP1? Meaning of hSRP1 medical term. What does hSRP1 mean?
https://medical-dictionary.thefreedictionary.com/hSRP1
OpenEmory | Search ResultsOpenEmory | Search Results
Satellite cells are stem cells with an essential role in skeletal muscle repair. Precise regulation of gene expression is critical for proper satellite cell quiescence, proliferation, differentiation and self-renewal. Nuclear proteins required for gene expression are dependent on the nucleocytoplasmic transport machinery to access to nucleus, however little is known about regulation of nuclear transport in satellite cells. The best characterized nuclear import pathway is classical nuclear import which depends on a classical nuclear localization signal (cNLS) in a cargo protein and the heterodimeric import receptors, karyopherin alpha (KPNA) and beta (KPNB). Multiple KPNA1 paralogs exist and can differ in importing specific cNLS proteins required for cell differentiation and function. We show that transcripts for six Kpna paralogs underwent distinct changes in mouse satellite cells during muscle regeneration accompanied by changes in cNLS proteins in nuclei. Depletion of KPNA1, the most ...
https://open.library.emory.edu/publications/search/?keywords=t&department=Pharmacology%3A+Admin&subject=Health+Sciences%2C+General&keywords=engin
Six classes of nuclear localization signals specific to different binding grooves of importinα<...Six classes of nuclear localization signals specific to different binding grooves of importinα<...
TY - JOUR. T1 - Six classes of nuclear localization signals specific to different binding grooves of importinα. AU - Kosugi, Shunichi. AU - Hasebe, Masako. AU - Matsumura, Nobutaka. AU - Takashima, Hideaki. AU - Miyamoto-Sato, Etsuko. AU - Tomita, Masaru. AU - Yanagawa, Hiroshi. PY - 2009/1/2. Y1 - 2009/1/2. N2 - The importin α/β pathway mediates nuclear import of proteins containing the classical nuclear localization signals (NLSs). Although the consensus sequences of the classical NLSs have been defined, there are still many NLSs that do not match the consensus rule and many nonfunctional sequences that match the consensus. We report here six different NLS classes that specifically bind to distinct binding pockets of importin α. By screening of random peptide libraries using an mRNA display, we selected peptides bound by importin α and identified six classes of NLSs, including three novel classes. Two noncanonical classes (class 3 and class 4) specifically bound the minor binding pocket ...
https://keio.pure.elsevier.com/en/publications/six-classes-of-nuclear-localization-signals-specific-to-different
Importin - WikipediaImportin - Wikipedia
Importin is a type of karyopherin that transports protein molecules into the nucleus by binding to specific recognition sequences, called nuclear localization sequences (NLS). Importin has two subunits, importin α and importin β. Members of the importin-β family can bind and transport cargo by themselves, or can form heterodimers with importin-α. As part of a heterodimer, importin-β mediates interactions with the pore complex, while importin-α acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo. The NLS-Importin α-Importin β trimer dissociates after binding to Ran GTP inside the nucleus, with the two importin proteins being recycled to the cytoplasm for further use. Importin can exist as either a heterodimer of importin-α/β or as a monomer of Importin-β. Importin-α was first isolated in 1994 by a group including Enno Hartmann, based at the Max Delbrück Center for Molecular Medicine. The process of nuclear protein import had already been ...
https://en.wikipedia.org/wiki/Importin
Lecture 6 10 - Lecture 6 Nuclear Import/Export Nuclear Import Receptors Importins Helps cargo get into nucleus does this by...Lecture 6 10 - Lecture 6 Nuclear Import/Export Nuclear Import Receptors Importins Helps cargo get into nucleus does this by...
View Notes - Lecture 6 10 from BICD 110 at UCSD. Lecture 6 10/10/07 Nuclear Import/Export Nuclear Import Receptors Importins Helps cargo get into nucleus does this by binding to cargo (protein with
https://www.coursehero.com/file/211136/Lecture-6-10/
Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3 | The Journal...Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA-Binding Activity of IFN Regulatory Factor 3 | The Journal...
Our results define a bipartite NLS that is integrated within the DNA-recognition region of IRF3. We mapped the NLS of IRF3 to aa 64-130, partially overlapping with the DBD. Basic amino acids KR77/78 and RK86/87 are required for efficient nuclear import of IRF3. Significantly, we demonstrate that the NLS of IRF3 also plays an important role in the DNA-binding activity.. The IRF family contains nine mammalian members (IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, IRF8, and IRF9), which are most conserved in their DBD. IRF1 and IRF2, which are closely related to each other, contain a conserved NLS located immediately C-terminal to the DBD, involving aa 120-138 (33). IRF4, IRF8, and IRF9 are highly conserved with each other and use the homologous NLS (aa 66-85) to direct their accumulation in the nucleus (34). Interestingly, IRF5 contains two monopartite consensus NLSs, a N-terminal NLS and a C-terminal NLS (35). Our study, together with previous reports, demonstrated that the NLSs of IRFs are generally ...
http://www.jimmunol.org/content/195/1/289
Mutagenetix > Incidental...Mutagenetix > Incidental...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002 ...
https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=255152
KPNA6 - Importin subunit alpha-7 - Homo sapiens (Human) - KPNA6 gene & proteinKPNA6 - Importin subunit alpha-7 - Homo sapiens (Human) - KPNA6 gene & protein
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
https://www.uniprot.org/uniprot/O60684
Nuclear localization of the DNA repair scaffold XRCC1: Uncovering the functional role of a bipartite NLS (Journal Article) |...Nuclear localization of the DNA repair scaffold XRCC1: Uncovering the functional role of a bipartite NLS (Journal Article) |...
We have characterized the nuclear localization signal (NLS) of XRCC1 structurally using X-ray crystallography and functionally using fluorescence imaging. Crystallography and binding studies confirm the bipartite nature of the XRCC1 NLS interaction with Importin α (Impα) in which the major and minor binding motifs are separated by ,20 residues, and resolve previous inconsistent determinations. Binding studies of peptides corresponding to the bipartite NLS, as well as its major and minor binding motifs, to both wild-type and mutated forms of Impα reveal pronounced cooperative binding behavior that is generated by the proximity effect of the tethered major and minor motifs of the NLS. The cooperativity stems from the increased local concentration of the second motif near its cognate binding site that is a consequence of the stepwise binding behavior of the bipartite NLS. We predict that the stepwise dissociation of the NLS from Impα facilitates unloading by providing a partially complexed ...
https://www.osti.gov/pages/biblio/1213717-nuclear-localization-dna-repair-scaffold-xrcc1-uncovering-functional-role-bipartite-nls
Exportin-2Exportin-2
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus ...
https://pharos.nih.gov/idg/targets/P55060
Nukleärer Import von 19S regulatorischen Komplexen in der Hefe Saccharomyces cerevisiaeNukleärer Import von 19S regulatorischen Komplexen in der Hefe Saccharomyces cerevisiae
Das 26S Proteasom führt die letzen Schritte des essentiellen, Ubiquitin abhängigen Proteinabbaus durch, indem es ubiquitinierte und fehlgefaltete Proteine erkennt und eliminiert. Da es in S. cerevisiae während allen Stadien der Zellteilung vornehmlich im Zellkern lokalisiert ist, ist der Importweg dieses 2,5 MDa umfassenden proteolytischen Komplexes in den Zellkern von besonderem Interesse. Das 26S Proteasom unterteilt sich in das katalytisch aktive 20S Proteasom sowie den 19S Regulatorkomplex. Für 20S Proteasomen konnten Lehmann und Mitarbeitende (2002, JMB, 317, 401) zeigen, dass Vorläuferkomplexe über den Karyopherin alpha/beta abhängigen Importweg in den Zellkern gelangen und dort zu 20S Proteasomen heranreifen. In dieser Arbeit wird gezeigt, dass die nukleäre Lokalisation der 19S Regulatorkomplexe ebenfalls von Karyopherin alpha/beta abhängt. Die Untersuchung der potentiellen klassischen Kernlokalisationssequenzen (cNLS) in den Untereinheiten des 19S Base Subkomplex ergab, dass ...
https://edoc.hu-berlin.de/handle/18452/15772
karyopherin beta 3 CRISPR Plasmids | SCBT - Santa Cruz Biotechnologykaryopherin beta 3 CRISPR Plasmids | SCBT - Santa Cruz Biotechnology
Santa Cruz Biotechnology, Inc. offers a broad range of karyopherin beta 3 CRISPR/Cas9 Knockout plasmids and karyopherin beta 3 Double Nickase Plasmids.
https://www.scbt.com/browse/gene-editing-CRISPR-Knockout-Activation-Products-transport-and-trafficking-crispr-knockout-and-activation-products-karyopherin-beta-3-CRISPR-Plasmids/_/N-1nbjt0h
KPNB1 (karyopherin (importin) beta 1)KPNB1 (karyopherin (importin) beta 1)
KPNB1 (karyopherin (importin) beta 1), Authors: Maria Giubettini, Pauline van der Watt, Annalisa Verrico, Valeria de Turris, Virna Leaner, Patrizia Lavia. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://www.atlasgeneticsoncology.org/Genes/KPNB1ID41101ch17q21.html
Structure Cluster - 1EE5: YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE 3D...Structure Cluster - 1EE5: YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE 3D...
1EE5: Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.
https://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1EE5
EuRBPDBEuRBPDB
Snurportin1 is a novel nuclear import receptor which contains an N-terminal importin beta binding domain which is essential for its function of a snRNP-specific nuclear import receptor [1]. Snurportin1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and digitonin-permeabilized HeLa cells [1]. ...
http://eurbpdb.syshospital.org/rbp_genelist.php?domain=Snurportin1&species=Mus_musculus
Quality Improvement PlanQuality Improvement Plan
Baycrest is pleased to share our Quality Improvement Plan (QIP) with our clients, family members and broader community. The QIP is a requirement under the Excellent Care For All Act, 2010 and was approved by the Baycrest Board of Directors.. This plan describes the key actions we are committed to taking to make improvements to the care and services you receive. As in previous years, these improvement priorities are rooted in our strategic goal to deliver exceptional quality of care and quality of life for our patients and residents.. Our QIP was developed with extensive feedback from clients, staff and physicians and reflects what they told us matters most to deliver safe, high quality care. Along with a review of our improvement achievements and challenges over the past year, required standards, legislation, and best practices, our QIP reflects consistent themes across our organization while at the same time, making sure these priorities reflect the specific needs of our long term care ...
http://www.baycrest.org/about/accountability-performance/quality-improvement-plan/
Importin and nucleoplasmin complex - Stock Image C025/1566 - Science Photo LibraryImportin and nucleoplasmin complex - Stock Image C025/1566 - Science Photo Library
Importin and nucleoplasmin complex, molecular model. Nucleoplasmin tags proteins for entry to the cell nucleus, while importin transports the protein across the nuclear membrane. - Stock Image C025/1566
http://www.sciencephoto.com/media/665805/view
ImportinImportin
is a type of protein that moves other protein molecules into the nucleus by binding to a specific recognition sequence, called the nuclear localization signal (NLS). Importin is classified as a karyopherin.…
https://en.academic.ru/dic.nsf/enwiki/2880444
Karyopherin (zebrafish) | Protein Target - PubChemKaryopherin (zebrafish) | Protein Target - PubChem
Protein target information for Karyopherin (zebrafish). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
https://pubchem.ncbi.nlm.nih.gov/protein/A0A0R4IMZ8
QIP 2014 Accepted PapersQIP 2014 Accepted Papers
Yanxiao Gong, Shengli Zhang, Ping Xu, Zhenda Xie and Shining Zhu. Realization of a hybrid squeeze operator via a single chi(2) nonlinear photonic crystal and its applications in quantum information ...
http://benasque.org/2014QIP/MondaySession.html
RCSB PDB - 4BA3: mImp alphadIBB A89NLS Macromolecule Annotations PageRCSB PDB - 4BA3: mImp alphadIBB A89NLS Macromolecule Annotations Page
4BA3: Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals.
http://www.rcsb.org/pdb/explore/derivedData.do?structureId=4BA3
Recombinant Human KPNA2 protein (ab123205) | AbcamRecombinant Human KPNA2 protein (ab123205) | Abcam
Buy our Recombinant Human KPNA2 protein. Ab123205 is a full length protein produced in Escherichia coli and has been validated in SDS-PAGE. Abcam provides free…
http://www.abcam.com/recombinant-human-kpna2-protein-ab123205.html
beta Karyopherins - Importin-beta Summary Report | CureHunterbeta Karyopherins - Importin-beta Summary Report | CureHunter
beta Karyopherins: Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.
http://www.curehunter.com/public/keywordSummaryD028961-beta-Karyopherins-Importin-beta.do
Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. | Molecular and...Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. | Molecular and...
The FG nucleoporins are a conserved family of proteins, some of which bind to the nuclear localization sequence receptor, karyopherin. Distinct members of this family are found in each region of the nuclear pore complex (NPC), spanning from the cytoplasmically disposed filaments to the distal end of the nuclear basket. Movement of karyopherin from one FG nucleoporin to the next may be required for translocation of substrates across the NPC. So far, nothing is known about how the FG nucleoporins are localized within the NPC. To identify proteins that interact functionally with one member of this family, the Saccharomyces cerevisiae protein Nup1p, we previously identified 16 complementation groups containing mutants that are lethal in the absence of NUP1 These mutants were referred to as nle (Nup-lethal) mutants. Mutants in the nle3/nlel7 complementation group are lethal in combination with amino-terminal nup1 truncation mutants, which we have previously shown to be defective for localization to ...
https://mcb.asm.org/content/16/5/2025
Peroxisomal long-chain fatty acid import protein 1 (P34230) - Yeast Metabolome DatabasePeroxisomal long-chain fatty acid import protein 1 (P34230) - Yeast Metabolome Database
Wiemann, S., Voss, H., Schwager, C., Rupp, T., Stegemann, J., Zimmermann, J., Grothues, D., Sensen, C., Erfle, H., Hewitt, N., et, a. l. .. (1993). Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene. Yeast 9:1343-1348.8154185 ...
http://www.ymdb.ca/proteins/P34230
Gene Ontology ClassificationsGene Ontology Classifications
Predicted to have nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in negative regulation of muscle cell differentiation and protein import into nucleus. Predicted to localize to the cytoplasm and nucleus. Orthologous to human TNPO2 (transportin 2 ...
http://www.informatics.jax.org/go/marker/MGI:2384849
How mRNAs traffic to the endoplasmic reticulum and controls protein import | Department of molecular geneticsHow mRNAs traffic to the endoplasmic reticulum and controls protein import | Department of molecular genetics
mRNAs encoding secreted and membrane proteins (mSMPs) were originally proposed to be recruited to the ER upon translation initiation as a part of an RNA-ribosome-nascent chain complex recognized by the signal recognition particle (SRP). However, it is becoming more and more apparent that cells use multiple means to import proteins into the ER via SRP-dependent and -independent mechanisms [Kraut-Cohen and Gerst, 2010]. Moreover, work from our lab using fluorescence microscopy and subcellular fractionation/RT-PCR has shown that a wide variety of mSMPs localize to ER membranes [Kraut-Cohen et al 2013]. Unlike mRNAs encoding polarity and secretion factors, which localize to cortical ER and are asymmetrically localized to polarized extensions in cells [Aronov et al 2007 and Gelin-Licht et al 2012], mSMPs localize to ER in mainly in the mother cell and are found in daughter cells after division. In addition, we show that mSMP localization to ER membranes is independent of both the SRP and translation ...
https://www.weizmann.ac.il/molgen/Gerst/research-activities/how-mrnas-traffic-endoplasmic-reticulum-and-controls-protein-import
QIP, A Component of the Vegetative RNA Silencing Pathway, is Essential for Meiosis and Suppresses Meiotic Silencing in...QIP, A Component of the Vegetative RNA Silencing Pathway, is Essential for Meiosis and Suppresses Meiotic Silencing in...
The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.. Online ISSN: 1943-2631. ...
http://www.genetics.org/content/early/2010/06/30/genetics.110.118422
admin, Author at Hand Therapyadmin, Author at Hand Therapy
Hand Therapy Group has been recognised for the quality and safety of their service with the award of accreditation by Quality Innovation Performance (QIP) at our Macquarie, Pacific and Hills Norwest practices. QIP is Australias most comprehensive not-for-profit accreditation organisation, dedicated to delivering accreditation and support services to a diverse…. ...
http://handtherapy.com.au/author/admin/
Long-Distance Distress Signal from Periphery of Injured Nerve Cells Begins with Locally Made Protein | CoAS | Drexel UniversityLong-Distance Distress Signal from Periphery of Injured Nerve Cells Begins with Locally Made Protein | CoAS | Drexel University
Video: Senior author Dr. Michael Fainzilber and lead author Rotem Ben-Tov Perry describe the new Neuron study in a video abstract.. Finding this evidence was far from simple: Importins are so crucial in the cells nucleus that even the smallest embryo could not survive without them. But Rotem Ben-Tov Perry, a research student at the Weizmann Institute who was lead author of the new study, found a way to distinguish the importin beta1 in the cell body from that in the axon: The axonal protein was apparently made from a longer version of messenger RNA, the cells working recipe for building a protein. To see if they could selectively affect just the axonal version of the protein, the Weizmann researchers worked with Drexels Twiss to take advantage of high precision knock-out technology. Rather than knocking a whole gene out of the system, they managed to remove one little piece of the messenger RNAs recipe for manufacturing importins- just the longer bit that sends the RNA to the axon.. Now they ...
http://drexel.edu/coas/academics/departments-centers/biology/news/2012/July/Injured-Nerve-Axons-Signal-Distress-with-Locally-Made-Protein/
Info Req. on Source of Nuclear Localization Signal for lac-Z gene.Info Req. on Source of Nuclear Localization Signal for lac-Z gene.
I am looking for NLS for lac-Z gene. I believe the NLS is now available commercially, but I have looked up some common suppliers with no success. I would appreciate if anyone can help me out with this. Or if knows of any source where I can get hold of NLS-LacZ plasmid. Thanks Obaid Khan ...
http://www.bio.net/bionet/mm/methods/1995-December/037939.html
NLS LENGTH SEMANTICS = CHAR import is too slowNLS LENGTH SEMANTICS = CHAR import is too slow
313175.1 Except import which takes way too long. I took a full export of WE8ISO8859p1 Database and now importing it in AL32UTF8. It is always difficult to prove where the slowness is coming from; but I think it has to do something with NLS_LENGTH_SEMANTICS. On the same server; if new database was in WE8ISO8859P1, a 5 million row table import took 2 hours; but in Al32UTF8 with NLS_LENGTH_SEMANTICS it is taking 1 day!!! Any idea how to improve the performance of import. ...
http://www.orafaq.com/usenet/comp.databases.oracle.server/2013/05/04/0011.htm
Tokotna Import Information Error ReportsTokotna Import Information Error Reports
This is the primary hub for reporting Import Errors on our companion site. Please note that IMPORTS ARE A WORK IN PROGRESS. We are only accepting specif... Tokotna Import Information Error Reports
https://www.deviantart.com/tokotas/journal/Tokotna-Import-Information-Error-Reports-776607389
TMCO6TMCO6
The SRP1 domain is Karyopherin(importin) alpha. This is involved in the exchange of molecules from the nucleus and the ... The SRP1 domain encodes alpha-Karyopherin (importin) and is known for intracellular trafficking and secretion on the membrane. ... The exchange involves the active transport by a carrier protein called karyopherins. A di-leucine motif is also abundant in ...
https://en.wikipedia.org/wiki/TMCO6
KPNA3KPNA3
"Entrez Gene: KPNA3 karyopherin alpha 3 (importin alpha 4)". Köhler, M; Speck C; Christiansen M; Bischoff F R; Prehn S; Haller H ... The similarities among these proteins suggests that karyopherin alpha-3 may be involved in the nuclear transport system. KPNA3 ... "Isolation and mapping of karyopherin alpha 3 (KPNA3), a human gene that is highly homologous to genes encoding Xenopus importin ... Importin subunit alpha-3 is a protein that in humans is encoded by the KPNA3 gene. The transport of molecules between the ...
https://en.wikipedia.org/wiki/KPNA3
KPNA6KPNA6
"Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)". Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of ... a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in ... Importin subunit alpha-7 is a protein that in humans is encoded by the KPNA6 gene. Nucleocytoplasmic transport, a signal- and ... Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by ...
https://en.wikipedia.org/wiki/KPNA6
KPNA4KPNA4
karyopherin subunit alpha-4, also known as importin alpha-3, is a protein that in humans is encoded by the KPNA4 gene. The ... "Entrez Gene: KPNA4 karyopherin alpha 4 (importin alpha 3)". Liu L, McBride KM, Reich NC (Jun 2005). "STAT3 nuclear import is ... "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family ... Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: ...
https://en.wikipedia.org/wiki/KPNA4
KPNA5KPNA5
"Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)". Bukrinsky MI, Haffar OK (2004). "HIV-1 nuclear import: in search of ... "Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family ... Importin subunit alpha-6 is a protein that in humans is encoded by the KPNA5 gene. The transport of molecules between the ... 1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import". J. Virol. 70 (2): 1027-32. doi: ...
https://en.wikipedia.org/wiki/KPNA5
ARL4AARL4A
... has been shown to interact with Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000122644 - Ensembl, May 2017 ...
https://en.wikipedia.org/wiki/ARL4A
PLAG1PLAG1
Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (2002). "Identification of a karyopherin alpha 2 recognition ... PLAG1 has been shown to interact with Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000181690 - Ensembl, May 2017 ... "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal". J. Biol. ...
https://en.wikipedia.org/wiki/PLAG1
RECQLRECQL
... has been shown to interact with KPNA4 and Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000004700 - Ensembl, May ... Seki T, Tada S, Katada T, Enomoto T (1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination ... "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability ...
https://en.wikipedia.org/wiki/RECQL
Nucleoporin 153Nucleoporin 153
Moroianu J, Blobel G, Radu A (1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the ... It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous ... Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): ... Brownawell AM, Macara IG (2002). "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding ...
https://en.wikipedia.org/wiki/Nucleoporin_153
UBR5UBR5
... has been shown to interact with: CIB1, Karyopherin alpha 1, MAPK1, and TOPBP1. GRCh38: Ensembl release 89: ENSG00000104517 ...
https://en.wikipedia.org/wiki/UBR5
KPNB1KPNB1
... has been shown to interact with: KPNA3, Karyopherin alpha 1, Karyopherin alpha 2, Mothers against decapentaplegic homolog ... Each of these subunits are part of the karyopherin family of proteins. Importin alpha binds the NLS-containing cargo in the ... Moroianu J, Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction ... Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta". Proc. ...
https://en.wikipedia.org/wiki/KPNB1
NUP98NUP98
Moroianu J, Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction ... Bonifaci N, Moroianu J, Radu A, Blobel G (May 1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". ... Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin beta3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): ... Bonifaci N, Moroianu J, Radu A, Blobel G (1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". Proc. ...
https://en.wikipedia.org/wiki/NUP98
Nuclear localization sequenceNuclear localization sequence
"Crystallographic analysis of the recognition of a nuclear localisation signal by the nuclear import factor karyopherin alpha". ... A protein translated with an NLS will bind strongly to importin (aka karyopherin), and, together, the complex will move through ... analysis of the specific yet versatile recognition of distinct nuclear localisation signals by karyopherin alpha". Structure. 8 ... also known as transportin or karyopherin β2), which then translocates the cargo protein into the nucleus. The structural basis ...
https://en.wikipedia.org/wiki/Nuclear_localization_sequence
Colin DingwallColin Dingwall
"Crystallographic analysis of the recognition of a nuclear localisation signal by the nuclear import factor karyopherin alpha". ... The broad outline of this model was confirmed ten years later by the crystallographic analysis of importin alpha complexed with ...
https://en.wikipedia.org/wiki/Colin_Dingwall
ImportinImportin
"Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha". ... Importin: IPO4, IPO5, IPO7, IPO8, IPO9, IPO11, IPO13 Karyopherin-α: KPNA1, KPNA2, KPNA3, KPNA4, KPNA5, KPNA6 Karyopherin-β: ... Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by ... Each one of these repeats contains two antiparallel alpha helices linked by a turn, which stack together to form the overall ...
https://en.wikipedia.org/wiki/Importin
ITK (gene)ITK (gene)
"Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)". Int. ...
https://en.wikipedia.org/wiki/ITK_(gene)
KPNA6 - ويكيبيدياKPNA6 - ويكيبيديا
"Entrez Gene: KPNA6 karyopherin alpha 6 (importin alpha 7)". مؤرشف من الأصل في 05 ديسمبر 2010.. الوسيط ,CitationClass=. تم ... KPNA6‏ (Karyopherin subunit alpha 6) هوَ بروتين يُشَفر بواسطة جين KPNA6 في الإنسان.[1][2] ... KPNA6, IPOA7, KPNA7, karyopherin subunit alpha 6. معرفات خارجية. الوراثة المندلية البشرية عبر الإنترنت 610563 MGI: MGI:1100836 ... Chook YM, Blobel G (2002). "Karyopherins and nuclear import". Curr. Opin. Struct. Biol. 11 (6): 703-15. doi:10.1016/S0959-440X( ...
https://ar.wikipedia.org/wiki/KPNA6
Importin αImportin α
Importin alpha, or karyopherin alpha refers to a class of adaptor proteins that are involved in the import of proteins into the ... Moroianu, J; Blobel, G; Radu, A (25 June 1996). "The binding site of karyopherin alpha for karyopherin beta overlaps with a ... "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import ... Wang, P.; Palese, P.; O'Neill, R. E. (1 March 1997). "The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus ...
https://en.wikipedia.org/wiki/Importin_α
Ebola viral protein 24Ebola viral protein 24
August 2014). "Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear ... KPNA proteins have 10 armadillo repeats each consisting of three alpha helices which determine their binding specificity, the ... Additionally, eVP24 inhibits interferon signaling by competitively binding to karyopherins which blocks phosphorylated STAT1 ... "The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import". The ...
https://en.wikipedia.org/wiki/Ebola_viral_protein_24
List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.157)
... karyopherins MeSH D12.776.157.530.750.500.100 - alpha karyopherins MeSH D12.776.157.530.750.500.249 - beta karyopherins MeSH ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.157.325.332.100.200 - gtp-binding protein alpha subunits, gi-go MeSH ... gtp-binding protein alpha subunits, gq-g11 MeSH D12.776.157.325.332.100.400 - gtp-binding protein alpha subunits, gs MeSH ... alpha subunit MeSH D12.776.157.057.061.500.500 - stat1 transcription factor MeSH D12.776.157.057.061.500.750 - stat2 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
IRF1IRF1
"Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: ...
https://en.wikipedia.org/wiki/IRF1
Transportin 1Transportin 1
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... The classical karyopherin receptor complex, such as the complex that uses Importin-β1 (encoded by gene KPNB1), is a heterodimer ... However, Transportin-1 can directly bind to the cargo proteins and may not need importin alpha subunit to do it. Transportin-1 ... Bonifaci N, Moroianu J, Radu A, Blobel G (Jun 1997). "Karyopherin beta2 mediates nuclear import of a mRNA binding protein". ...
https://en.wikipedia.org/wiki/Transportin_1
IPO5IPO5
... a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in ... Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between ... May 2020). "X-ray Structure of the Human Karyopherin RanBP5, an Essential Factor for Influenza Polymerase Nuclear Trafficking ... Yaseen NR, Blobel G (April 1997). "Cloning and characterization of human karyopherin beta3". Proceedings of the National ...
https://en.wikipedia.org/wiki/IPO5
KaryopherinKaryopherin
First, it is binding importin alpha - another type of karyopherin that binds the cargo protein in the cytoplasm-before the ... Most proteins require karyopherins to traverse the nuclear pore. Karyopherins can act as importins (i.e. helping proteins get ... Karyopherins at the US National Library of Medicine Medical Subject Headings (MeSH) Illustrations at berkeley.edu Karyopherin ... Karyopherins are proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell. The ...
https://en.wikipedia.org/wiki/Karyopherin
Karyopherin alpha 1Karyopherin alpha 1
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene. Karyopherin alpha 1 has been shown to ... "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import ... Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta ...
https://en.wikipedia.org/wiki/Karyopherin_alpha_1
Karyopherin alpha 2Karyopherin alpha 2
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... "Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)". Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC ... KPNA2 also may play a role in V(D)J recombination Karyopherin alpha 2 has been shown to interact with: ARL4A ITK, KPNB1, PLAG1 ... Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002). "Identification of a karyopherin alpha 2 ...
https://en.wikipedia.org/wiki/Karyopherin_alpha_2
Alpha solenoidAlpha solenoid
For example, the beta-karyopherin superfamily consists of alpha solenoid proteins formed from HEAT repeats; importin beta is a ... "alpha alpha superhelix". The CATH database uses the term "alpha horseshoe" for these proteins, and uses "alpha solenoid" for a ... An alpha solenoid (sometimes also known as an alpha horseshoe or as stacked pairs of alpha helices, abbreviated SPAH) is a ... Examples of alpha solenoid structures binding RNA and lipids have also been described. The term "alpha solenoid" has been used ...
https://en.wikipedia.org/wiki/Alpha_solenoid
List of MeSH codes (D12.776.543)List of MeSH codes (D12.776.543)
... karyopherins MeSH D12.776.543.585.750.500.100 - alpha karyopherins MeSH D12.776.543.585.750.500.249 - beta karyopherins MeSH ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.543.325.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH D12.776. ... alpha-1 MeSH D12.776.543.750.720.300.300.300.300.200 - receptors, adrenergic, alpha-2 MeSH D12.776.543.750.720.300.300.300.340 ... alpha MeSH D12.776.543.750.070.300.300.300.700 - receptors, adrenergic, alpha-1 MeSH D12.776.543.750.070.300.300.300.725 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)
Nucleoporin 62Nucleoporin 62
Karyopherin beta2 (transportin), a riboprotein transporter also interacts with p62. P62 also interacts with Nup93, and when ... This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear ... Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin β3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451- ... Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin β3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451- ...
https://en.wikipedia.org/wiki/Nucleoporin_62
HEAT repeatHEAT repeat
A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats ... Representative examples of HEAT repeat proteins include importin β (also known as karyopherin β) family, regulatory subunits of ... "Structure of importin-beta bound to the IBB domain of importin-alpha". Nature. 399 (6733): 221-229. Bibcode:1999Natur.399..221C ... "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp". Nature. 399 (6733): 230-237. doi:10.1038/20375. ...
https://en.wikipedia.org/wiki/HEAT_repeat
Cell nucleusCell nucleus
Most karyopherins interact directly with their cargo, although some use adaptor proteins.[11] Steroid hormones such as cortisol ... Like the components of other intermediate filaments, the lamin monomer contains an alpha-helical domain used by two monomers to ... Those karyopherins that mediate movement into the nucleus are also called importins, whereas those that mediate movement out of ... macromolecules such as RNA and proteins require association karyopherins called importins to enter the nucleus and exportins to ...
https://en.m.wikipedia.org/wiki/Cell_nuclei
XPO1XPO1
"Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. 110 (3): 349-60 ... Karyopherin. References[edit]. *^ a b c GRCh38: Ensembl release 89: ENSG00000082898 - Ensembl, May 2017 ...
https://en.wikipedia.org/wiki/XPO1
MicroRNAMicroRNA
Zuo Y, Qiang L, Farmer SR (March 2006). "Activation of CCAAT/enhancer-binding protein (C/EBP) alpha expression by C/EBP beta ... a member of the karyopherin family, recognizes a two-nucleotide overhang left by the RNase III enzyme Drosha at the 3' end of ... such as TNF alpha or GM-CSF. It has been demonstrated that given complete complementarity between the miRNA and target mRNA ... adipogenesis requires a peroxisome proliferator-activated receptor-gamma-associated repression of HDAC1 at the C/ebp alpha gene ...
https://en.wikipedia.org/wiki/MicroRNA
RCC1RCC1
"The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The ... "Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochemistry and Cell ... karyopherin alpha3/Qip". The Journal of Biological Chemistry. 275 (14): 10099-104. doi:10.1074/jbc.275.14.10099. PMID 10744690 ...
https://en.wikipedia.org/wiki/RCC1
DUT (gene)DUT (gene)
Though both isoforms contain the NLS, the sequence in DUT-M is sequestered away from cognate karyopherins. The isoelectric ... and identification of rat deoxyuridine triphosphatase as an inhibitor of peroxisome proliferator-activated receptor alpha". The ...
https://en.wikipedia.org/wiki/DUT_(gene)
Cell nucleusCell nucleus
Those karyopherins that mediate movement into the nucleus are also called importins, whereas those that mediate movement out of ... Like the components of other intermediate filaments, the lamin monomer contains an alpha-helical domain used by two monomers to ... Most karyopherins interact directly with their cargo, although some use adaptor proteins. Steroid hormones such as cortisol and ... October 2007). "LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in ...
https://en.wikipedia.org/wiki/Cell_nucleus
Ran (protein)Ran (protein)
Shamsher MK, Ploski J, Radu A (2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proc. Natl. Acad. Sci ... Percipalle P, Clarkson WD, Kent HM, Rhodes D, Stewart M (1997). "Molecular interactions between the importin alpha/beta ... Ran is involved in the transport of proteins across the nuclear envelope by interacting with karyopherins and changing their ... Chook YM, Blobel G (1999). "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp". Nature. 399 (6733): 230 ...
https://en.wikipedia.org/wiki/Ran_(protein)
NXF1NXF1
The Tap-C domain is made of four alpha helices packed against each other. The arrangement of helices 1, 2 and 3 is similar to ... Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings ...
https://en.wikipedia.org/wiki/NXF1
Transporter Classification DatabaseTransporter Classification Database
... including karyopherins 1.I.2 Plant plasmodesmata family 2.A.1 Major Facilitator superfamily (MFS), see also Lactose permease, ... Family 1.D.60 The Alpha,Gamma-Cyclic Peptide (AGCP) Family 1.D.61 The Anionophoric 2,6-Bis(Benzimidazol-2-yl)Pyridine (ABBP) ... Family 1.D.53 The alpha, gamma-Peptide Nanotube (a,gPepNT) Family 1.D.54 The potassium-selective Hexyl-Benzoureido-15-Crown-5- ... Ether Ion Channel (HBEC) Family 1.D.55 The Porphyrin-based Nanopore (PorNP) Family 1.D.56 The Alpha-Aminoisobutyrate (Aib) ...
https://en.wikipedia.org/wiki/Transporter_Classification_Database
Nuclear poreNuclear pore
... this family is further subdivided to the karyopherin-α and the karyopherin-β subfamilies. Other nuclear transport receptors ... of 34 distinct nucleoporin proteins.About half of the nucleoporins typically contain solenoid protein domains-either an alpha ... The largest family of nuclear transport receptors are karyopherins, which includes dozens of both importins and exportins; ...
https://en.wikipedia.org/wiki/Nuclear_pore
List of A1 genes, proteins or receptorsList of A1 genes, proteins or receptors
... alpha 1 Interleukin 13 receptor, alpha 1 Karyopherin alpha 1 Laminin, alpha 1 Major histocompatibility complex, class II, DP ... alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ... alpha 1 Collagen, type XIII, alpha 1 Collagen, type XIV, alpha 1 Collagen, type XV, alpha 1 Collagen, type XVI, alpha 1 ...
https://en.wikipedia.org/wiki/List_of_A1_genes,_proteins_or_receptors
Karyopherin alpha 1 - WikipediaKaryopherin alpha 1 - Wikipedia
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene. Karyopherin alpha 1 has been shown to ... "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import ... Percipalle, P; Clarkson W D; Kent H M; Rhodes D; Stewart M (Mar 1997). "Molecular interactions between the importin alpha/beta ...
https://en.wikipedia.org/wiki/Karyopherin_alpha_1
Karyopherin alpha 2 - WikipediaKaryopherin alpha 2 - Wikipedia
"Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... "Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)". Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC ... KPNA2 also may play a role in V(D)J recombination Karyopherin alpha 2 has been shown to interact with: ARL4A ITK, KPNB1, PLAG1 ... Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML (May 2002). "Identification of a karyopherin alpha 2 ...
https://en.wikipedia.org/wiki/Karyopherin_alpha_2
KPNA6 karyopherin subunit alpha 6 [Homo sapiens (human)] - Gene - NCBIKPNA6 karyopherin subunit alpha 6 [Homo sapiens (human)] - Gene - NCBI
importin subunit alpha-7. Names. importin alpha 7 subunit. importin-alpha-S2. karyopherin alpha 6 (importin alpha 7). ... KPNA6 karyopherin subunit alpha 6 [Homo sapiens] KPNA6 karyopherin subunit alpha 6 [Homo sapiens]. Gene ID:23633 ... HIV-1 Rev interacting protein, karyopherin alpha 6 (importin alpha 7) (KPNA6), is identified by the in-vitro binding ... karyopherin subunit alpha 6provided by HGNC. Primary source. HGNC:HGNC:6399 See related. Ensembl:ENSG00000025800 MIM:610563 ...
https://www.ncbi.nlm.nih.gov/gene/23633
karyopherin subunit alpha 2 ELISA Kits | Biocomparekaryopherin subunit alpha 2 ELISA Kits | Biocompare
Compare karyopherin subunit alpha 2 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... karyopherin subunit alpha 2 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for ... Provided below are ELISA kits targeting karyopherin subunit alpha 2, a human protein encoded by KPNA2. This protein is 529 ... Your search returned 37 karyopherin subunit alpha 2 ELISA Kit across 11 suppliers. ...
https://www.biocompare.com/pfu/110627/soids/2264827/ELISA_Kit/karyopherin_subunit_alpha_2
RCSB PDB - 1BK6: KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS Methods Report PageRCSB PDB - 1BK6: KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS Methods Report Page
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. ...
http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1BK6
3D View - 1BK6: KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS 3D View Report Page3D View - 1BK6: KARYOPHERIN ALPHA (YEAST) + SV40 T ANTIGEN NLS 3D View Report Page
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. ...
http://www.rcsb.org/pdb/explore/jmol.do?structureId=1BK6&bionumber=1
RCSB PDB - 1EE5: YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDERCSB PDB - 1EE5: YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE
Karyopherin alpha (importin alpha) is an adaptor molecule that recognizes proteins containing nuclear localization signals ( ... Karyopherin alpha (importin alpha) is an adaptor molecule that recognizes proteins containing nuclear localization signals ( ... KARYOPHERIN ALPHA. A. 424. Saccharomyces cerevisiae. Mutation(s): 1 Find proteins for Q02821 (Saccharomyces cerevisiae (strain ... YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE. *DOI: 10.2210/pdb1EE5/pdb ...
https://www.rcsb.org/structure/1EE5
LOC365232 (similar to karyopherin (importin) alpha 4) - Rat Genome DatabaseLOC365232 (similar to karyopherin (importin) alpha 4) - Rat Genome Database
similar to karyopherin (importin) alpha 4 LOC365232 similar to karyopherin (importin) alpha 4 (predicted) predicted is ... similar to karyopherin (importin) alpha 4 (predicted) Symbol and Name status set to provisional. 70820. PROVISIONAL. ...
https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1583798
WikiGenes - KPNA4 - karyopherin alpha 4 (importin alpha 3)WikiGenes - KPNA4 - karyopherin alpha 4 (importin alpha 3)
Synonyms: IPOA3, Importin alpha Q1, Importin subunit alpha-3, Karyopherin subunit alpha-4, MGC12217, ... ... Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, ... Assignment of KPNA4 and KPNB1 encoding karyopherin alpha 4 and beta 1 to human chromosome bands 11q22 and 17q21 respectively, ... Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability ...
https://www.wikigenes.org/e/gene/e/3840.html
karyopherin alpha 6 CRISPR Plasmids | SCBT - Santa Cruz Biotechnologykaryopherin alpha 6 CRISPR Plasmids | SCBT - Santa Cruz Biotechnology
offers a broad range of karyopherin alpha 6 CRISPR/Cas9 Knockout plasmids and karyopherin alpha 6 Double Nickase Plasmids. ... karyopherin alpha 6 gene silencers are available as karyopherin alpha 6 CRISPR/Cas9 Knockout plasmids and karyopherin alpha 6 ... karyopherin alpha 6 Antibodies for analysis of cellular responses to karyopherin alpha 6 CRISPR Products ... karyopherin alpha 6 CRISPR Knockout, HDR and Nickase Knockout Plasmids PRODUCT NAME. CATALOG #. Species. APPLICATIONS. MARKER. ...
https://www.scbt.com/browse/gene-editing-CRISPR-Knockout-Activation-Products-transport-and-trafficking-crispr-knockout-and-activation-products-karyopherin-alpha-6-CRISPR-Plasmids/_/N-yxvzbb
Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5 -...Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5 -...
Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5 ... Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5 X. ...
https://pubs.rsc.org/en/Content/ArticleLanding/OB/2017/C7OB00012J
Karyopherin alpha 5 | definition of karyopherin alpha 5 by Medical dictionaryKaryopherin alpha 5 | definition of karyopherin alpha 5 by Medical dictionary
What is karyopherin alpha 5? Meaning of karyopherin alpha 5 medical term. What does karyopherin alpha 5 mean? ... Looking for online definition of karyopherin alpha 5 in the Medical Dictionary? karyopherin alpha 5 explanation free. ... redirected from karyopherin alpha 5) KPNA5. A gene on chromosome 6q22.1 that encodes an alpha subunit of karyopherin, which ... Karyopherin alpha 5 , definition of karyopherin alpha 5 by Medical dictionary https://medical-dictionary.thefreedictionary.com/ ...
https://medical-dictionary.thefreedictionary.com/karyopherin+alpha+5
KPNA2 (karyopherin (importin) alpha 2) - KOMP (Knockout Mouse Project)KPNA2 (karyopherin (importin) alpha 2) - KOMP (Knockout Mouse Project)
Vega: OTTMUSG3580 (Kpna2, karyopherin (importin) alpha 2)*CCDS: 25565, 25565.1*OMIM: KARYOPHERIN ALPHA-2; KPNA2*Gene Ontology: ... karyopherin (importin) alpha 2. Synonyms: 2410044B12Rik, importin, Importin alpha, importin alpha 1, IPOA1, m-importin, m- ... importin-alpha-P1, pendulin, Rch1. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are updated daily ...
https://www.komp.org/geneinfo.php?geneid=65750
Targeting Nuclear Import Shuttles, Importins/Karyopherins Alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization...Targeting Nuclear Import Shuttles, Importins/Karyopherins Alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization...
... with endogenous human importins/karyopherins to determine the mechanism of NTM modulation of importin alpha-mediated nuclear ... Targeting Nuclear Import Shuttles, Importins/Karyopherins Alpha by a Peptide Mimicking the NFκB1/p50 Nuclear Localization ... with endogenous human importins/karyopherins to determine the mechanism of NTM modulation of importin alpha-mediated nuclear ...
https://www.moleculardevices.com/resources/publications/targeting-nuclear-import-shuttles-importins-karyopherins-alpha-by-a-peptide-mimicking-the-nuclear-localization-sequence
Die nukleäre Expression von Karyopherin alpha 2: ein prädiktiver Faktor für das Überleben von Patientinnen mit...Die nukleäre Expression von Karyopherin alpha 2: ein prädiktiver Faktor für das Überleben von Patientinnen mit...
Meiler, Robert Paul (2010) Die nukleäre Expression von Karyopherin alpha 2: ein prädiktiver Faktor für das Überleben von ... Die nukleäre Expression von Karyopherin alpha 2: ein prädiktiver Faktor für das Überleben von Patientinnen mit ... Karyopherin a2 (KPNA2) has been reported as a important factor of tumorgenesis and progression of breast cancer. The aim of ... Karyopherin α2 (KPNA2) stellte sich als ein wichtiger Faktor bezüglich Tumorentstehung und Fortschreiten des Mammakarzinoms dar ...
https://epub.uni-regensburg.de/17823/
Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer | Journal of Experimental ...Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer | Journal of Experimental ...
... a member of the karyopherin family, plays a vital role in carcinogenesis. Yet its role in colon cancer is poorly characterized ... Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, plays a vital role in carcinogenesis. Yet its role in colon ... Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer. *Yu Zhang1. , ... Hu ZY, Yuan SX, Yang Y, Zhou WP, Jiang H. Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has ...
https://jeccr.biomedcentral.com/articles/10.1186/s13046-015-0261-3
KPNA6 Gene - GeneCards | IMA7 Protein | IMA7 AntibodyKPNA6 Gene - GeneCards | IMA7 Protein | IMA7 Antibody
Karyopherin Subunit Alpha 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in ... KPNA6 (Karyopherin Subunit Alpha 6) is a Protein Coding gene. Diseases associated with KPNA6 include Lennox-Gastaut Syndrome. ... Acetylation of importin-alpha nuclear import factors by CBP/p300. (PMID: 10801418) Bannister AJ … Kouzarides T (Current biology ...
http://www.genecards.org/cgi-bin/carddisp.pl?gene=KPNA6&keywords=GH01G033035&prefilter=genomic_location
KPNA2 Gene - GeneCards | IMA1 Protein | IMA1 AntibodyKPNA2 Gene - GeneCards | IMA1 Protein | IMA1 Antibody
Karyopherin Subunit Alpha 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (Q6NVW7_HUMAN). *Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) ( ... Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... karyopherin (importin) alpha 2,56kDa,component of the nuclear protein complex (NPC),yeast SRP1 and Xenopus importin homolog, ...
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KPNA2
beta Karyopherins - Importin-beta Summary Report | CureHunterbeta Karyopherins - Importin-beta Summary Report | CureHunter
Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. ... Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules ... Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN ... GTP-BINDING PROTEIN causes release of karyopherin beta. ... formation by tethering karyopherin alpha 2 and karyopherin beta ...
http://www.curehunter.com/public/keywordSummaryD028961-beta-Karyopherins-Importin-beta.do
Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of...Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of...
Fingerprint Dive into the research topics of Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to ... T1 - Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of ... Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of ... Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of ...
https://utsouthwestern.pure.elsevier.com/en/publications/ebola-virus-vp24-targets-a-unique-nls-binding-site-on-karyopherin
Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma...Pleomorphic adenoma gene 1 mediates the role of karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma...
Karyopherin alpha 2 (KPNA2) promotes tumor growth in hepatocellular carcinoma (HCC). We aimed to determine the content and ... Karyopherin alpha 2 (KPNA2) is one of karyopherin a family, and could form heterodimer with Karyopherin 1 to promote nucleus ... Braem CV, Kas K, Meyen E, Debiec-Rychter M, Van De Ven WJ, Voz ML: Identification of a karyopherin alpha 2 recognition site in ... Karyopherin alpha 2 (KPNA2) promotes tumor growth in hepatocellular carcinoma (HCC). We aimed to determine the content and ...
https://jeccr.biomedcentral.com/articles/10.1186/s13046-014-0061-1
KPNA2 - Importin subunit alpha-1 - Homo sapiens (Human) - KPNA2 gene & proteinKPNA2 - Importin subunit alpha-1 - Homo sapiens (Human) - KPNA2 gene & protein
At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ... "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ... "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal ...
https://www.uniprot.org/uniprot/P52292
Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein importNpap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import
... by the importin-alpha:beta receptor. We now show that Npap60 (also called Nup50), a protein previously believed to be a ... structural component of the NPC, is a Ran binding protein and a cofactor for importin-alpha:be … ... alpha Karyopherins / genetics * alpha Karyopherins / metabolism* * beta Karyopherins / genetics * beta Karyopherins / ... The N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. Npap60:importin-alpha:beta ...
https://pubmed.ncbi.nlm.nih.gov/12176322/?dopt=Abstract
The Host-Dependent Interaction of Alpha-Importins With Influenza PB2 Polymerase Subunit Is Required for Virus RNA ReplicationThe Host-Dependent Interaction of Alpha-Importins With Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication
alpha Karyopherins / chemistry * alpha Karyopherins / metabolism* Substances * Mutant Proteins * Nuclear Localization Signals ... Alpha-importin was identified as a PB2-associated factor by proteomic analyses. To study the relevance of this interaction for ... Human alpha importin isoforms associated efficiently to PB2 protein of an H3N2 human virus but bound to diminished and variable ... The Host-Dependent Interaction of Alpha-Importins With Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication ...
https://pubmed.ncbi.nlm.nih.gov/19066626/?dopt=Abstract
KPNA6 - Importin subunit alpha-7 - Homo sapiens (Human) - KPNA6 gene & proteinKPNA6 - Importin subunit alpha-7 - Homo sapiens (Human) - KPNA6 gene & protein
At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta ... "Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.". Reid S. ... Importin subunit alpha-7Add BLAST. 536. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view ... IPR024931, Importing_su_alpha. Pfami. View protein in Pfam. PF00514, Arm, 8 hits. PF16186, Arm_3, 1 hit. PF01749, IBB, 1 ...
https://www.uniprot.org/uniprot/O60684
KEGG BRITE: KEGG Orthology (KO) - Saccharomyces cerevisiae (budding yeast)KEGG BRITE: KEGG Orthology (KO) - Saccharomyces cerevisiae (budding yeast)
YNL189W SRP1; karyopherin alpha YLR347C KAP95; karyopherin beta YJR042W NUP85; Nup85p YMR047C NUP116; FG-nucleoporin NUP116 ... YML085C TUB1; alpha-tubulin TUB1 YML124C TUB3; alpha-tubulin TUB3 YFL037W TUB2; beta-tubulin YPL174C NIP100; Nip100p YHR129C ... YML085C TUB1; alpha-tubulin TUB1 YML124C TUB3; alpha-tubulin TUB3 YNL148C ALF1; Alf1p YHR172W SPC97; Spc97p YNL126W SPC98; ... YML085C TUB1; alpha-tubulin TUB1 YML124C TUB3; alpha-tubulin TUB3 YFL037W TUB2; beta-tubulin YLR212C TUB4; gamma-tubulin ...
https://www.genome.jp/kegg-bin/get_htext?sce00001+YML085C
1ee5 - Proteopedia, life in 3D1ee5 - Proteopedia, life in 3D
BACKGROUND: Karyopherin alpha (importin alpha) is an adaptor molecule that recognizes proteins containing nuclear localization ... YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A NUCLEOPLASMIN NLS PEPTIDE. ... RESULTS: We report the crystal structures of two peptide complexes of yeast karyopherin alpha (Kapalpha): one with a human c- ... Karyopherin alpha): role for Srp1p and Sts1p in protein degradation. Mol Cell Biol. 2000 Aug;20(16):6062-73. PMID:10913188 ...
http://proteopedia.org/wiki/index.php/1ee5
Kpna4 alimentary system gene expressionKpna4 alimentary system gene expression
karyopherin (importin) alpha 4 MGI:1100848 .yui-skin-sam .yui-dt th{ background:url(http://www.informatics.jax.org/webshare/ ...
http://www.informatics.jax.org/gxd/summary?markerMgiId=MGI:1100848&structureID=EMAPA:16246&structure=alimentary%20system&tab=stagegridtab
Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients | BMC Medical...Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients | BMC Medical...
Signal transducers and activators of transcription (STAT) utilize karyopherins-alpha (KPNA) for their passage from cytoplasm ... of karyopherin-mediated nuclear transport in the onset and development of DGF. Additionally, it reveals that karyopherins could ... which includes genes encoding for several subtypes of karyopherins, a group of proteins involved in nucleocytoplasmic transport ... Karyopherin-alpha (also known as importin-alpha) is an adaptor protein that recognizes the first discovered or classical NLS, ...
https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-7-14
Nucleus-specific importin alpha proteins and nucleoporins regulate protein import and nuclear division in the binucleate...Nucleus-specific importin alpha proteins and nucleoporins regulate protein import and nuclear division in the binucleate...
thermophila encodes a large, karyopherin alpha-like protein family. The diagram in panel A depicts the conserved domains of ... Localization studies of 13 putative importin (imp) alpha- and 11 imp beta-like proteins revealed that imp alpha-like proteins ... These data suggest that micronucleus-specific proteins are transported by specific imp alpha adapters. The different imp alpha ... Nucleus-specific importin alpha proteins and nucleoporins regulate protein import and nuclear division in the binucleate ...
https://www.ncbi.nlm.nih.gov/pubmed?term=18676955
Subunit alphaProteinKPNA2NucleusKPNABindsAntibodyKPNB1Classical karyopherinHeterodimerAntigen2002CYTOSOLSignalsImportin alpha familyReceptorsAntibodiesAdaptorYEASTComplexesBetaFamilyPEPTIDEInteractMetabolismBindHumanImportReplication
Subunit alpha8
  • Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA1 gene. (wikipedia.org)
  • Proteins involved in the first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-2. (wikipedia.org)
  • Provided below are ELISA kits targeting karyopherin subunit alpha 2, a human protein encoded by KPNA2. (biocompare.com)
  • Other alias names for this protein include: importin subunit alpha-1, RAG cohort protein 1, importin subunit alpha-2, importin-alpha-P1, pendulin, IPOA1, and QIP2. (biocompare.com)
  • Your search returned 37 karyopherin subunit alpha 2 ELISA Kit across 11 suppliers. (biocompare.com)
  • KPNA6 (Karyopherin Subunit Alpha 6) is a Protein Coding gene. (genecards.org)
  • KPNA6 ‏ ( Karyopherin subunit alpha 6 ) هوَ بروتين يُشَفر بواسطة جين KPNA6 في الإنسان . (wikipedia.org)
  • Differential gene expression analysis suggested that sorafenib resistance correlated with high karyopherin subunit alpha 3 (KPNA3) expression. (jcancer.org)
Protein26
  • Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. (nih.gov)
  • The protein encoded by this gene is a member of the importin alpha family. (nih.gov)
  • This protein is 529 amino acids long, with a mass of 57.9 kDa, and is a member of the Importin alpha family. (biocompare.com)
  • A gene on chromosome 6q22.1 that encodes an alpha subunit of karyopherin, which plays a key role in nuclear protein import as an adapter protein for nuclear receptor KPNB1. (thefreedictionary.com)
  • Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. (curehunter.com)
  • Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta. (curehunter.com)
  • Karyopherin alpha 2 (KPNA2) is one of karyopherin a family, and could form heterodimer with Karyopherin 1 to promote nucleus protein import as an adapter protein [ 7 ]. (biomedcentral.com)
  • We now show that Npap60 (also called Nup50), a protein previously believed to be a structural component of the NPC, is a Ran binding protein and a cofactor for importin-alpha:beta-mediated import. (nih.gov)
  • Human alpha importin isoforms associated efficiently to PB2 protein of an H3N2 human virus but bound to diminished and variable extents to PB2 from H5N1 avian or human strains, suggesting that the function of alpha importin during RNA replication is important for the adaptation of avian viruses to the human host. (nih.gov)
  • Tabb MM, Tongaonkar P, Vu L, Nomura M. Evidence for separable functions of Srp1p, the yeast homolog of importin alpha (Karyopherin alpha): role for Srp1p and Sts1p in protein degradation. (proteopedia.org)
  • Nucleus-specific importin alpha proteins and nucleoporins regulate protein import and nuclear division in the binucleate Tetrahymena thermophila. (nih.gov)
  • Disruption of the IMA10 gene encoding an imp alpha-like protein that accumulates in dividing micronuclei results in nuclear division defects and lethality. (nih.gov)
  • Thus, nucleus-specific protein import and nuclear function in Tetrahymena are regulated by diverse, specialized karyopherins. (nih.gov)
  • The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. (genetex.com)
  • KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. (acris-antibodies.com)
  • KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. (acris-antibodies.com)
  • Karyopherins shuttle their NLS-containing cargo through nuclear pore complexes (NPCs), protein channels that permeate the nuclear membrane. (asm.org)
  • The imp α proteins have a characteristic structure consisting of an amino (N)-terminal imp β-binding (IBB) domain of ∼100 amino acids (aa) that is followed by 8 to 10 alpha-helical armadillo (ARM) repeats that span most of the remainder of the protein. (asm.org)
  • Dies wurde in vitro durch Bindung des Adapterproteins Karyopherin-alpha an CKII-phosphoryliertes Terminales Protein bestätigt. (hu-berlin.de)
  • Moreover, its functionality was depended on CKII activity that was verified by in vitro binding experiments of terminal protein to the import adaptor karyopherin-alpha. (hu-berlin.de)
  • Many nuclear proteins possess a nuclear localisation signal (NLS) that is recognised by the importer protein importin-alpha. (eu.org)
  • Importin-alpha is an adaptor protein for importin-beta which interacts with nuclear pore components to effect transport into the nucleus. (eu.org)
  • In addition to binding plant karyopherin α, VirE3 interacts with VirE2, a major bacterial protein that directly associates with the T‐DNA and facilitates its nuclear import. (deepdyve.com)
  • Karyopherin α2 was first identified as Rch-1, an NLS receptor which interacts with the RAG-1 recombination-activating protein in developing B and T cells. (bdbiosciences.com)
  • A nucleocytoplasmic transport protein that binds to ALPHA KARYOPHERINS and RAN GTP BINDING PROTEIN inside the CELL NUCLEUS and participates in their export into CYTOPLASM. (curehunter.com)
  • Moroianu J, Blobel G, Radu A. Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta. (proteopedia.org)
KPNA25
  • KPNA2 also may play a role in V(D)J recombination Karyopherin alpha 2 has been shown to interact with: ARL4A ITK, KPNB1, PLAG1, RECQL, and SGK. (wikipedia.org)
  • Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, plays a vital role in carcinogenesis. (biomedcentral.com)
  • KPNA2 is a member of the karyopherin α-family, also known as importin α-1 or RAG cohort 1, weighs about 58 kDa and consist of 529 amino acids [ 5 ]. (biomedcentral.com)
  • Karyopherin alpha 2 (KPNA2) promotes tumor growth in hepatocellular carcinoma (HCC). (biomedcentral.com)
  • Recent studies show that Karyopherin alpha 2 (KPNA2) is up-regulated in quite a number of cancers and associated with poor prognosis. (pubmedcentralcanada.ca)
Nucleus12
  • Karyopherins act as carrier proteins between the cytoplasm and the nucleus. (biomedcentral.com)
  • At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. (genecards.org)
  • Although some molecules are able to diffuse through the large Nucleus Pore Complexes (NPCs) in the nucleus membrane, factors larger than 45 kDa including that associated with malignant diseases need to be mediated by karyopherin to import into the nucleus [ 6 ]. (biomedcentral.com)
  • Interestingly, the most up-regulated pathway at both time points was NLS-bearing substrate import into nucleus , which includes genes encoding for several subtypes of karyopherins, a group of proteins involved in nucleocytoplasmic transport. (biomedcentral.com)
  • Signal transducers and activators of transcription (STAT) utilize karyopherins-alpha (KPNA) for their passage from cytoplasm into the nucleus. (biomedcentral.com)
  • Localization studies of 13 putative importin (imp) alpha- and 11 imp beta-like proteins revealed that imp alpha-like proteins are nucleus specific--nine localized to the germ line micronucleus--but that most imp beta-like proteins localized to both types of nuclei. (nih.gov)
  • After their synthesis, TFs are transported into the nucleus a process regulated by karyopherins commonly known as importin alpha and β. (plantphysiol.org)
  • We have shown that 20S core particles are translocated into the nucleus as inactive precursor complexes via the classical karyopherin alpha/beta import pathway (Lehmann et al. (hu-berlin.de)
  • The importin-β family of transport receptors, also called karyopherins, or more specifically, importins or exportins, carries cargoes both into and out of the nucleus. (genetics.org)
  • Here, we demonstrate that VirE3 is transferred from Agrobacterium to the plant cell and then imported into its nucleus via the karyopherin α‐dependent pathway. (deepdyve.com)
  • Our data indicate that VirE3 can mimic this VIP1 function, acting as an 'adapter' molecule between VirE2 and karyopherin α and 'piggy‐backing' VirE2 into the host cell nucleus. (deepdyve.com)
  • Most proteins imported into the nucleus contain a classical nuclear localization signal (cNLS) sequence that is recognized by members of the karyopherin-α (also known as KPNA or importin-α) family and mediates their nuclear import. (sciencemag.org)
KPNA2
  • Summary During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) nuclear transporters. (elsevier.com)
  • A, Immunoblotting with Flag antibody in HEK293T cells expressing either one of 7 members of Flag-tagged karyopherin alpha (KPNA) family (top left). (aacrjournals.org)
Binds5
  • Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. (nih.gov)
  • The N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. (nih.gov)
  • Npap60:importin-alpha:beta binds cargo and can stimulate nuclear import. (nih.gov)
  • The monopartite nuclear localisation signal (mNLS) binds to the major site of importin-alpha. (eu.org)
  • Nevertheless, it is clear that most proteins do specify their own import signal and, of these, the vast majority have an NLS that binds to importin-alpha (also termed karyopherin-alpha). (eu.org)
Antibody2
  • Immunohistochemical analysis of paraffin-embedded KYSE170 xenograft, using karyopherin alpha 3(GTX106324) antibody at 1:500 dilution. (genetex.com)
  • Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10,000 dilution of the mouse anti-karyopherin antibody. (bdbiosciences.com)
KPNB12
  • Karyopherin alpha 1 has been shown to interact with KPNB1 and UBR5. (wikipedia.org)
  • Because RAN is a small GTPase that regulates nuclear transport controlled by karyopherin subunit beta 1 (KPNB1), RAN was further analyzed together with KPNB1. (frontiersin.org)
Classical karyopherin1
  • Compared with wild-type, passive export rates of a classical karyopherin/importin (Kap) Kap60p/Kap95p-targeted NLS-GFP reporter (cNLS-GFP) were significantly faster in nup188- Δ and nup170- Δ cells. (rupress.org)
Heterodimer1
  • The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. (nih.gov)
Antigen1
  • Antigen standard for karyopherin alpha 3 (importin alpha 4) (KPNA3) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
20021
  • Für 20S Proteasomen konnten Lehmann und Mitarbeitende (2002, JMB, 317, 401) zeigen, dass Vorläuferkomplexe über den Karyopherin alpha/beta abhängigen Importweg in den Zellkern gelangen und dort zu 20S Proteasomen heranreifen. (hu-berlin.de)
CYTOSOL2
  • Nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. (curehunter.com)
  • Importin-alpha must be returned to the cytosol to repeat the process. (eu.org)
Signals5
  • Karyopherin alpha (importin alpha) is an adaptor molecule that recognizes proteins containing nuclear localization signals (NLSs). (rcsb.org)
  • Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha. (proteopedia.org)
  • Conti E, Kuriyan J. Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha. (proteopedia.org)
  • The import of proteins containing nuclear localization signals (NLSs) is facilitated by karyopherin proteins, also known as importins. (asm.org)
  • Many cargoes destined for nuclear import carry nuclear localization signals that are recognized by karyopherins (Kaps). (rupress.org)
Importin alpha family1
  • Belongs to the importin alpha family. (abcam.com)
Receptors2
  • Tumorigenesis and tumor progression are associated with dysfunction of the nuclear transport machinery at the level of import and export receptors (karyopherins) [ 3 ]. (biomedcentral.com)
  • This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. (antibodies-online.com)
Antibodies1
  • A molecular docking and dynamics study concluded that R521C and R521H mutations in FUS (show FUS Antibodies ) result in weak binding with Karyopherin-beta2 leading to amyotrophic lateral sclerosis. (antibodies-online.com)
Adaptor1
  • Importin-alpha is itself an adaptor for the nuclear transport receptor importin-beta. (eu.org)
YEAST2
  • RESULTS: We report the crystal structures of two peptide complexes of yeast karyopherin alpha (Kapalpha): one with a human c-myc NLS peptide, determined at 2.1 A resolution, and one with a Xenopus nucleoplasmin NLS peptide, determined at 2.4 A resolution. (proteopedia.org)
  • In yeast and humans, which contain at least 14 and 20 karyopherins, respectively, most are members of the imp β family. (asm.org)
Complexes1
  • Here, we provide evidence that nuclear import of base and lid complexes also depends on karyopherin alpha/beta. (hu-berlin.de)
Beta8
  • Interestingly, the arginine-rich NLS of Rex uses importin beta for import but does so by a mechanism that is importin alpha independent. (curehunter.com)
  • Many nuclear-targeted proteins are transported through the nuclear pore complex (NPC) by the importin-alpha:beta receptor. (nih.gov)
  • These results identify Npap60 as a cofactor for importin-alpha:beta nuclear import and as a previously unidentified subunit of the importin complex. (nih.gov)
  • There are two subfamilies of karyopherins: importin alpha and importin beta ( Tamura and Hara-Nishimura, 2014 ). (plantphysiol.org)
  • In dieser Arbeit wird gezeigt, dass die nukleäre Lokalisation der 19S Regulatorkomplexe ebenfalls von Karyopherin alpha/beta abhängt. (hu-berlin.de)
  • Unsere Daten unterstützen ein Modell wonach die nukleären 26S Proteasomen aus Subkomplexen zusammengelagert werden, die durch Karyopherin alpha/beta in den Zellkern gelangen. (hu-berlin.de)
  • Our data support the model by which nuclear 26S proteasomes are assembled from subcomplexes imported by karyopherin alpha/beta. (hu-berlin.de)
  • Finally, binding of RanGTP to importin-beta drives cargo release, with the importin-alpha still being bound to nucleoporins located on the nucleoplasmic side. (eu.org)
Family2
  • Importin-alpha constitutes a multiprotein family in Metazoa with generally similar but perhaps not identical binding specificities ( Mason,2009 ). (eu.org)
  • Heterodimers belonging to a highly conserved family of proteins called karyopherins are required for successful nuclear localization of cytosolic proteins. (bdbiosciences.com)
PEPTIDE1
  • The authors analyzed interaction of a hydrophobic peptide, derived from the bifunctional nuclear transport modifier (NTM) peptide, with endogenous human importins/karyopherins to determine the mechanism of NTM modulation of importin alpha-mediated nuclear transport. (moleculardevices.com)
Interact1
  • To identify the import machineries that interact with these different pores, we characterized the large families of karyopherin homologs encoded within the genome. (nih.gov)
Metabolism1
  • Akt1/PKB alpha plays an important role in cell proliferation and cell metabolism. (antibodies-online.com)
Bind1
Human3
  • 1996). "Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import" . (wikipedia.org)
  • Recombinant Human Importin alpha 5. (novusbio.com)
  • High-efficiency synthesis of human alpha-endorphin and magainin in the erythrocytes of transgenic mice: a production system for therapeutic peptides. (labome.org)
Import2
  • Karyopherins and nuclear import. (nih.gov)
  • Nup53p and Nup59p (but not Nup170p) contain FG repeats that act as binding sites for the import karyopherin, Kap121p. (rupress.org)
Replication2
  • Karyopherin Alpha 6 Is Required for Replication of Porcine Reproductive and Respiratory Syndrome Virus and Zika Virus. (nih.gov)
  • These results indicate that, above and beyond its role in nuclear accumulation, PB2 interaction with alpha-importins is required for virus RNA replication. (nih.gov)
RCSB PDB - 1EE4: CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE
RCSB PDB - 1EE4: CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE (rcsb.org)
1ee5 - Proteopedia, life in 3D
1ee5 - Proteopedia, life in 3D (proteopedia.org)
Global Gene Expression Analysis in a Mouse Model for Norrie Disease: Late Involvement of Photoreceptor Cells | IOVS | ARVO...
Global Gene Expression Analysis in a Mouse Model for Norrie Disease: Late Involvement of Photoreceptor Cells | IOVS | ARVO... (iovs.arvojournals.org)
Anti-KPNA5 antibody (ab125529) | Abcam
Anti-KPNA5 antibody (ab125529) | Abcam (abcam.com)
Structure Gallery | Max Planck Institute of Biochemistry
Structure Gallery | Max Planck Institute of Biochemistry (biochem.mpg.de)
Addgene: pCMVTNT-T7-KPNA2
Addgene: pCMVTNT-T7-KPNA2 (addgene.org)
Karyopherin subunit alpha 2 ELISA Kits | Biocompare
Karyopherin subunit alpha 2 ELISA Kits | Biocompare (biocompare.com)
The human pathology proteome in pancreatic cancer - The Human Protein Atlas
The human pathology proteome in pancreatic cancer - The Human Protein Atlas (proteinatlas.org)
Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle...
Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle... (bmccancer.biomedcentral.com)
Anti-KPNA6 antibody (ab105350) | Abcam
Anti-KPNA6 antibody (ab105350) | Abcam (abcam.com)
Anti-KPNA3 antibody [C3], C-term | GeneTex
Anti-KPNA3 antibody [C3], C-term | GeneTex (genetex.com)
KPNA3 / Importin alpha-3 antibody | acris-antibodies.com
KPNA3 / Importin alpha-3 antibody | acris-antibodies.com (acris-antibodies.com)
KPNA5 / Importin alpha-6 antibody | acris-antibodies.com
KPNA5 / Importin alpha-6 antibody | acris-antibodies.com (acris-antibodies.com)
LOC365232 (similar to karyopherin (importin) alpha 4) - Rat Genome Database
LOC365232 (similar to karyopherin (importin) alpha 4) - Rat Genome Database (rgd.mcw.edu)
Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients | BMC Medical...
Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients | BMC Medical... (bmcmedgenomics.biomedcentral.com)
YRC Public Data Repository - Protein Overview - SRP1 / YNL189W
YRC Public Data Repository - Protein Overview - SRP1 / YNL189W (yeastrc.org)
KPNA4 / Importin alpha-4 antibody | acris-antibodies.com
KPNA4 / Importin alpha-4 antibody | acris-antibodies.com (acris-antibodies.com)
Nucleus-Specific Importin Alpha Proteins and Nucleoporins Regulate Protein Import and Nuclear Division in the Binucleate...
Nucleus-Specific Importin Alpha Proteins and Nucleoporins Regulate Protein Import and Nuclear Division in the Binucleate... (ec.asm.org)
Plus it
Plus it (plantphysiol.org)
Oligomerization of Ebola Virus VP40 Is Essential for Particle Morphogenesis and Regulation of Viral Transcription | Journal of...
Oligomerization of Ebola Virus VP40 Is Essential for Particle Morphogenesis and Regulation of Viral Transcription | Journal of... (jvi.asm.org)
Anti-NTF97/Importin beta/kpnb1 antibody [3E9] (ab2811)
Anti-NTF97/Importin beta/kpnb1 antibody [3E9] (ab2811) (abcam.com)
Anti-Nup153 antibody [QE5] (ab24700) | Abcam
Anti-Nup153 antibody [QE5] (ab24700) | Abcam (abcam.com)
Plus it
Plus it (cancerres.aacrjournals.org)
KPNA2 / Importin alpha-2 antibody | acris-antibodies.com
KPNA2 / Importin alpha-2 antibody | acris-antibodies.com (acris-antibodies.com)
ELM - Detail for TRG_NLS_MonoExtN_4
ELM - Detail for TRG_NLS_MonoExtN_4 (elm.eu.org)