Oligo-1,6-Glucosidase
alpha-Glucosidases
1-Deoxynojirimycin
Polyisoprenyl Phosphate Oligosaccharides
Oligosaccharides
Swainsonine
beta-Glucosidase
Calnexin
Alkaloids
Glycoproteins
Substrate Specificity
Endoplasmic Reticulum
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Glycosylation
alpha 1-Antitrypsin
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Chromatography, Gel
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Hypoxia-Inducible Factor 1, alpha Subunit
alpha7 Nicotinic Acetylcholine Receptor
Integrin alpha3beta1
Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.
Integrin alpha4
Integrin alpha6
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
Integrin alpha5beta1
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Interleukin-1alpha
Integrin alpha2beta1
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Receptors, Adrenergic, alpha-1
Integrin alpha5
Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Receptors, Adrenergic, alpha-2
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Integrin alpha6beta1
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Base Sequence
Integrin alpha6beta4
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Integrin alpha Chains
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Integrin alpha1
Alpha Rhythm
Integrin alpha3
An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.
alpha 1-Antitrypsin Deficiency
Protein Binding
Receptors, Nicotinic
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
PPAR alpha
Dinoprost
Adrenergic alpha-Antagonists
Hepatocyte Nuclear Factor 1-alpha
Binding Sites
Alternative splicing of transcripts encoding the alpha- and beta-subunits of mouse glucosidase II in T lymphocytes. (1/973)
Glucosidase II is a processing enzyme of the endoplasmic reticulum that functions to hydrolyze two glucose residues in immature N -linked oligosaccharides attached to newly synthesized polypeptides. We previously reported the cDNA cloning of the alpha- and beta-subunits of mouse glucosidase II from T cells following copurification of these proteins with the highly glycosylated transmembrane protein-tyrosine phosphatase CD45. Subsequent examination of additional cDNA clones, coupled with partial genomic DNA sequencing, has revealed that both subunits are encoded by gene products that undergo alternative splicing in T lymphocytes. The catalytic alpha-subunit possesses two variably expressed segments, box Alpha1, consisting of 22 amino acids located proximal to the amino-terminus, and box Alpha2, composed of 9 amino acids situated between the amino-terminus and the putative catalytic site in the central region of the molecule. Box Beta1, a variably expressed 7 amino acid segment in the beta-subunit of glucosidase II, is located immediately downstream of an acidic stretch near the carboxyl-terminus. Screening of reverse transcribed RNA by polymerase chain reaction confirms the variable inclusion of each of these segments in transcripts obtained from a panel of T-lymphocyte cell lines. Thus, distinct isoforms of glucosidase II exist that may perform specialized functions. (+info)The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. (2/973)
The putative biosynthetic gene cluster for the alpha-glucosidase inhibitor acarbose was identified in the producer Actinoplanes sp. 50/110 by cloning a DNA segment containing the conserved gene for dTDP-D-glucose 4,6-dehydratase, acbB. The two flanking genes were acbA (dTDP-D-glucose synthase) and acbC, encoding a protein with significant similarity to 3-dehydroquinate synthases (AroB proteins). The acbC gene was overexpressed heterologously in Streptomyces lividans 66, and the product was shown to be a C7-cyclitol synthase using sedo-heptulose 7-phosphate, but not ido-heptulose 7-phosphate, as its substrate. The cyclization product, 2-epi-5-epi-valiolone ((2S,3S,4S,5R)-5-(hydroxymethyl)cyclohexanon-2,3,4,5-tetrol), is a precursor of the valienamine moiety of acarbose. A possible five-step reaction mechanism is proposed for the cyclization reaction catalyzed by AcbC based on the recent analysis of the three-dimensional structure of a eukaryotic 3-dehydroquinate synthase domain (Carpenter, E. P., Hawkins, A. R., Frost, J. W., and Brown, K. A. (1998) Nature 394, 299-302). (+info)Trypanosoma cruzi calreticulin is a lectin that binds monoglucosylated oligosaccharides but not protein moieties of glycoproteins. (3/973)
Trypanosoma cruzi is a protozoan parasite that belongs to an early branch in evolution. Although it lacks several features of the pathway of protein N-glycosylation and oligosaccharide processing present in the endoplasmic reticulum of higher eukaryotes, it displays UDP-Glc:glycoprotein glucosyltransferase and glucosidase II activities. It is herewith reported that this protozoan also expresses a calreticulin-like molecule, the third component of the quality control of glycoprotein folding. No calnexin-encoding gene was detected. Recombinant T. cruzi calreticulin specifically recognized free monoglucosylated high-mannose-type oligosaccharides. Addition of anti-calreticulin serum to extracts obtained from cells pulse-chased with [35S]Met plus [35S]Cys immunoprecipitated two proteins that were identified as calreticulin and the lysosomal proteinase cruzipain (a major soluble glycoprotein). The latter but not the former protein disappeared from immunoprecipitates upon chasing cells. Contrary to what happens in mammalian cells, addition of the glucosidase II inhibitor 1-deoxynojirimycin promoted calreticulin-cruzipain interaction. This result is consistent with the known pathway of protein N-glycosylation and oligosaccharide processing occurring in T. cruzi. A treatment of the calreticulin-cruzipain complexes with endo-beta-N-acetylglucosaminidase H either before or after addition of anti-calreticulin serum completely disrupted calreticulin-cruzipain interaction. In addition, mature monoglucosylated but not unglucosylated cruzipain isolated from lysosomes was found to interact with recombinant calreticulin. It was concluded that the quality control of glycoprotein folding appeared early in evolution, and that T. cruzi calreticulin binds monoglucosylated oligosaccharides but not the protein moiety of cruzipain. Furthermore, evidence is presented indicating that glucosyltransferase glucosylated cruzipain at its last folding stages. (+info)Murine acid alpha-glucosidase: cell-specific mRNA differential expression during development and maturation. (4/973)
Acid alpha-glucosidase (GAA) cleaves the alpha1-4 and alpha1-6 glycosidic linkages of glycogen and related alpha-glucosyl substrates within lysosomes. Its deficiency results in glycogen storage disease type II (GSDII) variants including Pompe disease. To gain insight into the tissue patterns of involvement by glycogen storage in GSDII, GAA mRNA expression in mouse tissues was evaluated by Northern blot and in situ hybridization analyses. Extensive temporal and spatial variation of GAA mRNA was observed. During preterm maturation, GAA mRNA levels of whole mice progressively increased as assessed by Northern analysis. By in situ hybridization with GAA antisense mRNA, low signals were detected in most tissues throughout gestation. However, increased expression in specific cell types of different tissues was observed beginning at 16 days post coitum in developing brain neurons, primitive inner ear cells, and seminiferous tubular epithelium. In adult mice, whole-organ GAA mRNA levels were highest in brain, moderate in heart, liver, and skeletal muscle, and lowest in the series kidney > lung > testis > spleen. By in situ hybridization, the highest-intensity signals were in neurons of the central and peripheral nervous systems whereas neuroglial cells had only low-level signal. Signals of moderate intensity were in cardiomyocytes whereas low signals were in hepatocytes and skeletal muscle myocytes and very low in cells of the lungs, thymus, pancreas, spleen, and adrenal glands. However, testicular Sertoli cells and kidney tubular epithelial cells had significant signals even though surrounding cells had very low signals. The discrete temporal and spatial variations of GAA mRNA during development indicate different physiological roles for this enzyme in various cell types and developmental stages. (+info)Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with N-butyldeoxynojirimycin. (5/973)
Sandhoff disease is a neurodegenerative disorder resulting from the autosomal recessive inheritance of mutations in the HEXB gene, which encodes the beta-subunit of beta-hexosaminidase. GM2 ganglioside fails to be degraded and accumulates within lysosomes in cells of the periphery and the central nervous system (CNS). There are currently no therapies for the glycosphingolipid lysosomal storage diseases that involve CNS pathology, including the GM2 gangliosidoses. One strategy for treating this and related diseases is substrate deprivation. This would utilize an inhibitor of glycosphingolipid biosynthesis to balance synthesis with the impaired rate of catabolism, thus preventing storage. One such inhibitor is N-butyldeoxynojirimycin, which currently is in clinical trials for the potential treatment of type 1 Gaucher disease, a related disease that involves glycosphingolipid storage in peripheral tissues, but not in the CNS. In this study, we have evaluated whether this drug also could be applied to the treatment of diseases with CNS storage and pathology. We therefore have treated a mouse model of Sandhoff disease with the inhibitor N-butyldeoxynojirimycin. The treated mice have delayed symptom onset, reduced storage in the brain and peripheral tissues, and increased life expectancy. Substrate deprivation therefore offers a potentially general therapy for this family of lysosomal storage diseases, including those with CNS disease. (+info)Androgen regulation of glycosidase secretion in epithelial cell cultures from human epididymis. (6/973)
The human epididymis and its secretions actively promote sperm fertilizing capacity and provide protection for spermatozoa against harmful influences. Among epididymal secretions, glycosidases have been recently studied and associated with molecular changes on the sperm surface. In the present work, we studied the influence of different concentrations of testosterone, dihydrotestosterone and cyproterone acetate on the secretion of alpha-glucosidase, N-acetyl-glucosaminidase, beta-glucuronidase and alpha-mannosidase by isolated and cultured epithelial cells from human caput, corpus and cauda epididymides. Cell cultures were obtained from aggregates of isolated tubule fragments plated on extracellular matrix-covered multi-well plates. Activities of the glycosidases were measured in conditioned culture media and were higher in the distal regions of the epididymis. Testosterone and dihydrotestosterone significantly increase the enzyme secretion in a concentration-dependent manner. This increase was higher in corpus and/or cauda than in caput epididymis. Cyproterone acetate caused a dose-dependent decrease in glycosidase secretion in cultures from all epididymal regions. It is concluded that the secretion of epididymal glycosidases is regulated by androgen, being stimulated by dihydrotestosterone and testosterone and inhibited by the androgen antagonist cyproterone acetate. (+info)Coordinate transcriptional control in the hyperthermophilic archaeon Sulfolobus solfataricus. (7/973)
The existence of a global gene regulatory system in the hyperthermophilic archaeon Sulfolobus solfataricus is described. The system is responsive to carbon source quality and acts at the level of transcription to coordinate synthesis of three physically unlinked glycosyl hydrolases implicated in carbohydrate utilization. The specific activities of three enzymes, an alpha-glucosidase (malA), a beta-glycosidase (lacS), and an alpha-amylase, were reduced 4-, 20-, and 10-fold, respectively, in response to the addition of supplementary carbon sources to a minimal sucrose medium. Western blot analysis using anti-alpha-glucosidase and anti-beta-glycosidase antibodies indicated that reduced enzyme activities resulted exclusively from decreased enzyme levels. Northern blot analysis of malA and lacS mRNAs revealed that changes in enzyme abundance arose primarily from reductions in transcript concentrations. Culture conditions precipitating rapid changes in lacS gene expression were established to determine the response time of the regulatory system in vivo. Full induction occurred within a single generation whereas full repression occurred more slowly, requiring nearly 38 generations. Since lacS mRNA abundance changed much more rapidly in response to a nutrient down shift than to a nutrient up shift, transcript synthesis rather than degradation likely plays a role in the regulatory response. (+info)Purification and characterization of an alpha-glucosidase from Rhizobium sp. (Robinia pseudoacacia L.) strain USDA 4280. (8/973)
A novel alpha-glucosidase with an apparent subunit mass of 59 +/- 0. 5 kDa was purified from protein extracts of Rhizobium sp. strain USDA 4280, a nodulating strain of black locust (Robinia pseudoacacia L), and characterized. After purification to homogeneity (475-fold; yield, 18%) by ammonium sulfate precipitation, cation-exchange chromatography, hydrophobic chromatography, dye chromatography, and gel filtration, this enzyme had a pI of 4.75 +/- 0.05. The enzyme activity was optimal at pH 6.0 to 6.5 and 35 degrees C. The activity increased in the presence of NH4+ and K+ ions but was inhibited by Cu2+, Ag+, Hg+, and Fe2+ ions and by various phenyl, phenol, and flavonoid derivatives. Native enzyme activity was revealed by native gel electrophoresis and isoelectrofocusing-polyacrylamide gel electrophoresis with fluorescence detection in which 4-methylumbelliferyl alpha-glucoside was the fluorogenic substrate. The enzyme was more active with alpha-glucosides substituted with aromatic aglycones than with oligosaccharides. This alpha-glucosidase exhibited Michaelis-Menten kinetics with 4-methylumbelliferyl alpha-D-glucopyranoside (Km, 0.141 microM; Vmax, 6.79 micromol min-1 mg-1) and with p-nitrophenyl alpha-D-glucopyranoside (Km, 0.037 microM; Vmax, 2.92 micromol min-1 mg-1). Maltose, trehalose, and sucrose were also hydrolyzed by this enzyme. (+info) Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that affects the liver and lungs. It is caused by mutations in the SERPINA1 gene, which codes for alpha-1 antitrypsin (AAT), a protein produced in the liver that helps protect the body against proteolytic enzymes, such as elastase and neutrophil elastase. These enzymes are involved in inflammation and tissue damage.
People with AATD have low levels of functional AAT in their blood, which can lead to premature lung disease and liver disease. The most common form of AATD is caused by the Pi*Z phenotype, which results from a missense mutation in the SERPINA1 gene. This mutation leads to misfolding and accumulation of AAT in the liver, where it is normally broken down and secreted into the bloodstream.
The most common symptoms of AATD are:
* Chronic obstructive pulmonary disease (COPD)
* Emphysema
* Lung fibrosis
* Liver cirrhosis
* Gallstones
The diagnosis of AATD is based on a combination of clinical symptoms, laboratory tests, and genetic analysis. Treatment for AATD typically involves managing the underlying symptoms and preventing complications. For example, individuals with COPD may receive bronchodilators and corticosteroids to help improve lung function and reduce inflammation. Liver disease may be treated with medications to slow the progression of cirrhosis or with liver transplantation in severe cases.
The goal of genetic counseling for AATD is to provide information about the risk of transmitting the disorder to offspring and to discuss options for prenatal testing and family planning. Prenatal testing can be performed on a fetus by analyzing a sample of cells from the placenta or amniotic fluid. Carrier testing can also be performed in individuals who have a family history of AATD.
The prognosis for AATD varies depending on the severity of the mutation and the specific symptoms present. With appropriate management, many individuals with AATD can lead active and productive lives. However, the disorder can be severe and life-threatening in some cases, especially if left untreated or if there is a delay in diagnosis.
Currently, there is no cure for AATD, and treatment is focused on managing symptoms and preventing complications. However, research into the genetics of AATD is ongoing, and new developments in gene therapy and other areas may provide hope for improved treatments and outcomes in the future.
Alpha-glucosidase
Alglucosidase alfa Alpha-glucosidase inhibitor alpha-Glucosidases at the US National Library of Medicine Medical Subject ... α-Glucosidase breaks down starch and disaccharides to glucose. Other glucosidases include: Cellulase Beta-glucosidase ... Trout liver α-glucosidases were extracted and characterized. It was shown that for one of the trout liver α-glucosidases ... Yeast and rat small intestinal α-glucosidases have been shown to be inhibited by several groups of flavonoids. α-Glucosidases ...
Glucan endo-1,3-alpha-glucosidase
... (EC 3.2.1.59, endo-1,3-alpha-glucanase, mutanase, endo-(1->3)-alpha-glucanase, cariogenase, ... Glucan+endo-1,3-alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC ... 3-alpha-D-glucan) are nigerose and alpha-D-glucose. Hasegawa S, Nordin JH (October 1969). "Enzymes that hydrolyze fungal cell ... alpha-D-glucan 3-glucanohydrolase) is an enzyme with systematic name 3-alpha-D-glucan 3-glucanohydrolase. The enzyme catalyses ...
Lysosomal alpha-glucosidase
... may refer to: Glucan 1,4-a-glucosidase, an enzyme Acid alpha-glucosidase, an enzyme This set index ...
Acid alpha-glucosidase
... , also called α-1,4-glucosidase and acid maltase, is an enzyme (EC 3.2.1.20) that helps to break down ... Ratner L, vander Heyden N, Dedera D (March 1991). "Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase ... Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of ... Hermans MM, Kroos MA, van Beeumen J, Oostra BA, Reuser AJ (July 1991). "Human lysosomal alpha-glucosidase. Characterization of ...
Sucrose alpha-glucosidase
... (EC 3.2.1.48, sucrose alpha-glucohydrolase, sucrase, sucrase-isomaltase, sucrose.alpha.- ... Sucrose+alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.2.1). ... This enzyme catalyses the following chemical reaction Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type action ... the other serving as a sucrose alpha-glucosidase. Conklin KA, Yamashiro KM, Gray GM (August 1975). "Human intestinal sucrase- ...
Alpha-glucosidase inhibitor
Hence, alpha-glucosidase inhibitors reduce the impact of dietary carbohydrates on blood sugar. Examples of alpha-glucosidase ... Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha- ... acarbose inhibits pancreatic alpha-amylase in addition to alpha-glucosidase, and is degraded by gut bacterial maltogenic alpha- ... Development of alpha-glucosidase inhibitor from medicinal herbs]" 药用植物来源的α-葡萄糖苷酶抑制剂研究进展 [Development of
Amylo-alpha-1,6-glucosidase
... (EC 3.2.1.33, amylo-1,6-glucosidase, dextrin 6-alpha-D-glucosidase, amylopectin 1,6-glucosidase, ... dextrin-1,6-glucosidase, glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase) is an enzyme with systematic name ... Lee EY, Carter JH, Nielsen LD, Fischer EH (May 1970). "Purification and properties of yeast amylo-1,6-glucosidase--oligo-1,4 ... Nelson TE, Kolb E, Larner J (April 1969). "Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4- ...
Glucan 1,3-alpha-glucosidase
... (EC 3.2.1.84, exo-1,3-alpha-glucanase, glucosidase II, 1,3-alpha-D-glucan 3-glucohydrolase) is an ... Glucan+1,3-alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.2.1) ... This enzyme catalyses the following chemical reaction Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D- ... enzyme with systematic name 3-alpha-D-glucan 3-glucohydrolase. ...
Branched-dextran exo-1,2-alpha-glucosidase
2-alpha-glucosidase (EC 3.2.1.115, dextran 1,2-alpha-glucosidase, dextran alpha-1,2 debranching enzyme, 1,2-alpha-D-glucosyl- ... Branched-dextran+exo-1,2-alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ... This enzyme catalyses the following chemical reaction Hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of ... Mitsuishi Y, Kobayashi M, Matsuda K (August 1980). "Dextran alpha-(1 yields 2)-debranching enzyme from Flavobacterium Sp. M-73 ...
Hesperidin 6-O-alpha-L-rhamnosyl-beta-D-glucosidase
... (EC 3.2.1.168) is an enzyme with systematic name hesperetin 7-(6-O-alpha-L- ... doi:10.1007/s00203-011-0709-6. Hesperidin+6-O-alpha-L-rhamnosyl-beta-D-glucosidase at the US National Library of Medicine ... rhamnopyranosyl-beta-D-glucopyranoside) 6-O-alpha-rhamnopyranosyl-beta-glucohydrolase. This enzyme catalyses the following ...
Maltose-6'-phosphate glucosidase
This enzyme is also called phospho-alpha-glucosidase. As of late 2007, only one structure has been solved for this class of ... In enzymology, a maltose-6'-phosphate glucosidase (EC 3.2.1.122) is an enzyme that catalyzes the chemical reaction maltose 6'- ... "Purification from Fusobacterium mortiferum ATCC 25557 of a 6-phosphoryl-O-alpha-D-glucopyranosyl:6-phosphoglucohydrolase that ... hydrolyzes maltose 6-phosphate and related phospho-alpha-D-glucosides". J. Bacteriol. 177 (9): 2505-12. doi:10.1128/jb.177.9. ...
Protein-glucosylgalactosylhydroxylysine glucosidase
Isolation and characterization of a rat kidney alpha-glucosidase of high specificity". J. Biol. Chem. 254 (20): 10329-36. PMID ... Hamazaki H, Hotta K (1979). "Purification and characterization of an alpha-glucosidase specific for hydroxylysine-linked ... Other names in common use include 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-, and lysine glucohydrolase ... The systematic name of this enzyme class is protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase. ...
Mannosyl-oligosaccharide glucosidase
... processing alpha-glucosidase I, Glc3Man9NAc2 oligosaccharide glucosidase, trimming glucosidase I, GCS1) is an enzyme with ... and partial characterization of Saccharomyces cerevisiae processing alpha glucosidase I". Glycobiology. 12 (3): 229-34. doi: ... Mannosyl-oligosaccharide+glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ( ... Rat liver microsomal glucosidases which process oligosaccharides". The Journal of Biological Chemistry. 254 (18): 8814-8. PMID ...
Enzyme replacement therapy
"GAA: glucosidase alpha, acid". NIH Genetics Home Reference. US Government. (All pages needing factual verification, Wikipedia ...
Glucosidases
Members marked with a "#" are considered by MeSH to be glucosidases. Alpha-glucosidases are targeted by alpha-glucosidase ... Glucosidases are the glycoside hydrolase enzymes categorized under the EC number 3.2.1. Alpha-glucosidases are enzymes involved ... "α-Glucosidases". Biochemistry (Moscow). 66 (3): 267-281. doi:10.1023/A:1010243611814. Glucosidases at the US National Library ... They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked ...
Glycoside hydrolase family 31
... alpha-glucosidase (EC 3.2.1.20), alpha-galactosidase (EC 3.2.1.22); glucoamylase (EC 3.2.1.3), sucrase-isomaltase (EC 3.2.1.48 ... Hermans MM, Kroos MA, van Beeumen J, Oostra BA, Reuser AJ (July 1991). "Human lysosomal alpha-glucosidase. Characterization of ... Homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal alpha-glucosidase". European Journal of ... and lysosomal alpha-glucosidase. GH31 in CAZypedia Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995 ...
GANC
Kamimura H, Ogata H, Takahara H (1992). "Alpha-glucoside formation of xenobiotics by rat liver alpha-glucosidases". Drug ... Neutral alpha-glucosidase C is an enzyme that in humans is encoded by the GANC gene. Glycoside hydrolase enzymes hydrolyse the ... "Entrez Gene: GANC glucosidase, alpha; neutral C". Feizi T, Larkin M (Sep 1990). "AIDS and glycosylation". Glycobiology. 1 (1): ... Martiniuk F, Hirschhorn R, Smith M (Oct 1980). "Assignment of the gene for human neutral alpha-glucosidase C to chromosome 15 ...
Glycoside hydrolase family 15
... alpha-glucosidase (EC 3.2.1.20); glucodextranase (EC 3.2.1.70). Glucoamylase (GA) catalyses the release of D-glucose from the ... The protein belongs to the mainly alpha class, and contains 19 helices and 9 strands. Henrissat B, Callebaut I, Fabrega S, Lehn ...
GANAB
"Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II". J. ... "Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies ... Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene. GANAB has been shown to interact with ... Ratner L, vander Heyden N, Dedera D (1991). "Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity". ...
Voglibose
Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after ... Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for ... Chen X, Zheng Y, Shen Y (2006). "Voglibose (Basen, AO-128), one of the most important alpha-glucosidase inhibitors". Current ... Dabhi AS, Bhatt NR, Shah MJ (December 2013). "Voglibose: an alpha glucosidase inhibitor". Journal of Clinical and Diagnostic ...
Maltase-glucoamylase
"Entrez Gene: maltase-glucoamylase (alpha-glucosidase)". Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E (January ... Alpha-glucosidase Maltase ENSG00000282607 GRCh38: Ensembl release 89: ENSG00000257335, ENSG00000282607 - Ensembl, May 2017 ... Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity ... Frandsen TP, Svensson B (May 1998). "Plant alpha-glucosidases of the glycoside hydrolase family 31. Molecular properties, ...
Glucan 1,6-a-glucosidase
Glucan 1,6-alpha-glucosidase (EC 3.2.1.70, exo-1,6-beta-glucosidase, glucodextrinase, glucan alpha-1,6-D-glucohydrolase) is an ... Glucan+1,6-alpha-glucosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (EC 3.2.1) ... This enzyme catalyses the following chemical reaction: Hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D- ... Sawai T, Yamaki T, Ohya T (1976). "Preparation and some properties of Arthrobacter globiformis exo-1,6-α-glucosidase". Agric. ...
Glycogen debranching enzyme
6-glucosidase (EC 3.2.1.33), or glucosidase, cleaves the remaining alpha-1,6 linkage, producing glucose and a linear chain of ... Yamamoto E, Makino Y, Omichi K (May 2007). "Active site mapping of amylo-alpha-1,6-glucosidase in porcine liver glycogen ... Gillard BK, White RC, Zingaro RA, Nelson TE (September 1980). "Amylo-1,6-glucosidase/4-alpha-glucanotransferase. Reaction of ... Gillard BK, Nelson TE (September 1977). "Amylo-1,6-glucosidase/4-alpha-glucanotransferase: use of reversible substrate model ...
Trefoil knot fold
... and lysosomal alpha-glucosidase (EC 3.2.1.20). Human gene encoding proteins containing the trefoil domain include: acid alpha- ... SCOP alpha/beta knot fold CATH alpha/beta knot topology pKNOT the web server to detect knots in proteins Tkaczuk KL, Dunin- ... glucosidase, MGAM, TFF1, TFF2, TFF3, and ZP4. Zarembinski TI, Kim Y, Peterson K, Christendat D, Dharamsi A, Arrowsmith CH, ... The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. ...
Glycoside hydrolase family 4
... alpha-galactosidase (EC 3.2.1.22); alpha-D-glucuronidase (EC 3.2.1.139). 6-phospho-alpha-glucosidase requires both NAD(H) and ... dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily". The Journal of Biological ... Glycoside hydrolase family 4 CAZY GH_4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase (EC 3.2.1.86 ...
Maltase
... alpha-D-glucosidase, alpha-glucoside hydrolase, alpha-1,4-glucosidase, alpha-D-glucoside glucohydrolase) is one type of alpha- ... Maltase (EC 3.2.1.20, alpha-glucosidase, glucoinvertase, glucosidosucrase, maltase-glucoamylase, alpha-glucopyranosidase, ... Alpha-amylase 1 which is coded on the AMY1A gene is responsible of cleaving α-glucosidase linkages in oligosaccharides and ... The following are genes that can code for maltase: Acid alpha-glucosidase which is coded on the GAA gene is essential to ...
Diplazium esculentum
The extract also had alpha-glucosidase inhibitory activity. Yam phak khut, a Thai salad of fern leaves and pork Ensaladang pako ... 28 (2). Chai TT, Yeoh LY, Mohd Ismail NI, Ong HC, Abd Manan F, Wong FC (2015) Evaluation of glucosidase inhibitory and ...
Miglitol
Alpha-glucosidase inhibitor Miglustat Voglibose "Migliotl: MedlinePlus Drug Information". MedlinePlus. National Institutes of ... v t e (ECHA InfoCard ID from Wikidata, Alpha-glucosidase inhibitors, Iminosugars, Piperidines, Polyols, All stub articles, ... In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not ... Miglitol, and other structurally-related iminosugars, inhibit glycoside hydrolase enzymes called alpha-glucosidases. Since ...
Polycystic kidney disease 3 (autosomal dominant)
7] GANAB glucosidase II alpha subunit Homo sapiens (human). Gene ID:23193, 2016. Chen J, Deng F, Singh SV, Wang QJ (May 2008 ... The GANAB gene codes the catalytic alpha subunit of glucosidase II and noncatalytic beta subunit; the glycosyl hydrolase 31 ... The heterodimeric glucosidase II enzyme has an important function in protein folding and catalyzes the hydrolysis of glucose ... Yuan J, Rey O, Rozengurt E (2006). "Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the ...
Streptomyces galbus
Drug Concentration Monitoring Microbial Alpha-Glucosidase Inhibitors Plasminogen Activators. Berlin, Heidelberg: Springer ...
Naringinase
It is a multienzyme complex which possesses alpha-L-rhamnosidase and beta glucosidase active centers. The E.C. No.(EC 3.2.1.40 ... Lastly glucosidase breaks prunin into glucose and naringenin, a flavorless flavanone also found in various citrus. Ram gene is ...
Angelicin
Notably, this reaction uses alpha-ketoglutarate which is reduced to succinate both of which are involved in the Krebs cycle. ... Dehghan, Hossein; Sarrafi, Yaghoub; Salehi, Peyman; Ebrahimi, Samad Nejad (2017-04-01). "α-Glucosidase inhibitory and ...
Lipid signaling
This signaling lipid has great affinity for the GRP55 receptor and the PPAR alpha receptor. It has been identified as an anti- ... In turn, certain β-glucosidases hydrolyze these lipids to regenerate ceramide. GluCer appears to be synthesized in the inner ... studies in cells have shown that ceramide-inducing agents such as tumor necrosis factor-alpha α (TNFα) and palmitate induce the ...
Glycogen phosphorylase
... and then a α1-6 glucosidase enzyme is required to break the remaining (single glucose) α1-6 residue that remains in the new ... catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4- ...
Malbranchea cinnamomea
... such as alpha-glucosidases, xylanases, alpha-amylases, and glucanases. The genome of M. cinnamomea has been published in 2017 ...
Chebulagic acid
It has been found to be immunosuppressive, hepatoprotective, and a potent alpha-glucosidase inhibitor, a human gut enzyme ... Pham, AT; Malterud, KE; Paulsen, BS; Diallo, D; Wangensteen, H (2014). "α-Glucosidase inhibition, 15-lipoxygenase inhibition, ...
Glycosidic bond
It is worth noting that Wen-Ya Lu utilized glucosidase in a reverse manner opposite to the enzyme's biological functionality: ... investigated use of cellobiose phosphorylase (CP) toward synthesis of alpha-glycosides in ionic liquids. The best condition for ... one example being Wen-Ya Lu's conversion of D-Glucose to Ethyl β-D-glucopyranoside using naturally-derived glucosidase. ...
Actinoplanes utahensis
... is a species of bacteria and a source of the drug acarbose, an alpha-glucosidase inhibitor used in the ...
Inborn errors of metabolism
Acid-alpha glucosidase for Pompe disease Gene therapy Bone marrow or organ transplantation Treatment of symptoms and ...
GCS1
Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked ... Ratner L, vander Heyden N, Dedera D (1991). "Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity". ... Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G (Sep 1996). "Localization of the human glucosidase I gene to ... "Entrez Gene: GCS1 glucosidase I". Goodman CD, McFadden GI (2008). "Gamete Fusion: Key Protein Identified". Current Biology. 18 ...
Pseudogymnoascus destructans
Under laboratory conditions, P. destructans has been shown to produce numerous enzymes including β-glucosidase, esterase/ ... alpha/beta-galactosidase, β-glucuronidase, α-fucosidase, α-mannosidase, and trypsin. Important dual virulence factors found in ...
Cellulase
McCleary BV (November 1980). "New chromogenic substrates for the assay of alpha-amylase and (1 leads to 4)-β-D-glucanase". ... The ancillary enzyme present in the reagent mixture (β-glucosidase) then acts to hydrolyse the fragment containing the ... Cellobiases (EC 3.2.1.21) or β-glucosidases hydrolyse the exocellulase product into individual monosaccharides. Oxidative ... Separation and characterization of cellulases and β-glucosidases". The Biochemical Journal. 177 (1): 9-19. doi:10.1042/ ...
Acarviosin
Alpha-glucosidase inhibitors, Disaccharides, Amino sugars, Cyclitols, Cyclohexenes). ...
Indigestion
Alpha-glucosidase inhibitor, amylin analogs, GLP-1 receptor antagonists), antihypertensive medications (angiotensin converting ...
MAPK13
2009). "Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an ... 2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection ...
Inulinase
... which has one alpha helix. Being made of beta sheets allows the structures to be more stable during chemical reactions. Both of ... glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369-1380. doi:10.1021/ja01247a029. Liu Y, Zhou SH, Cheng YR, Chi Z, ...
Hypoglycemia
... alpha-glucosidase inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase IV inhibitors, do not cause ... as well as medical treatment with an alpha-glucosidase inhibitor, diazoxide, or octreotide. Some causes of hypoglycemia require ...
Alpha-D-xyloside xylohydrolase
... alpha-D-glucosidases". Planta. 214 (3): 406-13. doi:10.1007/s004250100631. PMID 11859845. Lovering AL, Lee SS, Kim YW, Withers ... Alpha-D-xyloside xylohydrolase (EC 3.2.1.177, alpha-xylosidase) is an enzyme. This enzyme catalyses the following chemical ... into alpha-glucosidase". FEBS Letters. 580 (11): 2707-11. doi:10.1016/j.febslet.2006.04.025. PMID 16631751. Larsbrink J, Izumi ... non-reducing alpha-D-xylose residues with release of alpha-D-xylose. The enzyme catalyses hydrolysis of a terminal, ...
17α-Estradiol
... glucosidase inhibitor or a Nrf2‐inducer". Aging Cell. 15 (5): 872-884. doi:10.1111/acel.12496. ISSN 1474-9718. PMC 5013015. ... "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". ... "Quantitative structure-activity relationship of various endogenous estrogen metabolites for human estrogen receptor alpha and ...
Structural bioinformatics
... such as alpha-helix, beta-sheets, and loops (secondary structure). Also, weak interactions (such as hydrogen bonds) stabilize ... "Molecular Dynamics Gives New Insights into the Glucose Tolerance and Inhibition Mechanisms on β-Glucosidases". Molecules. 24 ( ...
Hypospermia
The biochemical markers that are measured are alpha-glucosidase (in the epididymis), fructose (in the seminal vesicles) and ...
Snodgrassella alvi
Tests of the strains for β-glucosidase, β-galactosidase, indole production, proteolysis of gelatin, and glucose fermentation ... phylum Actinobacteria), Gilliamella apicola, Frischella perrara, Bartonella apis, and Alpha 2.1 (phylum Proteobacteria). ...
Sucrase
EC 3.2.1.10 is isomaltase EC 3.2.1.26 is invertase EC 3.2.1.48 is sucrose alpha-glucosidase Sucrose intolerance (also known as ...
DailyMed - Search Results for alpha-Glucosidase Inhibitor
Alpha-glucosidase inhibitors: MedlinePlus Medical Encyclopedia Image
Alpha Glucosidase Inhibitors - PubMed
Alpha glucosidase is an intestinal brush border enzyme responsible for the hydrolysis of disaccharides which is necessary for ... Alpha glucosidase inhibitors have been shown to be effective in improving glycemic control in type 2 diabetes. Two alpha ... Alpha Glucosidase Inhibitors No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [ ... Usefulness of antidiabetic alpha-glucosidase inhibitors: a review on the timing of administration and effects on gut hormones. ...
Alpha Glucosidase Inhibitors - PubMed
Alpha glucosidase is an intestinal brush border enzyme responsible for the hydrolysis of disaccharides which is necessary for ... Alpha glucosidase inhibitors have been shown to be effective in improving glycemic control in type 2 diabetes. Two alpha ... Alpha Glucosidase Inhibitors No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [ ... Usefulness of antidiabetic alpha-glucosidase inhibitors: a review on the timing of administration and effects on gut hormones. ...
Pediatric Type 2 Diabetes Mellitus Medication: Biguanides, Sulfonylureas, Meglitinides, Alpha-glucosidase inhibitors,...
Pediatric Type 2 Diabetes Mellitus Medication: Biguanides, Sulfonylureas, Meglitinides, Alpha-glucosidase inhibitors,...
Lysosomal Alpha Glucosidase (GAA) Antibody - Connecting Americans to Their Personal Health Care
... glucosidase activity, glucosidase alpha, glucosidase assay, glucosidase enzyme, glucosidase function, glucosidase ii, ... Lysosomal Alpha Glucosidase (GAA) Antibody. April 12, 2022. Jamie Lysosomal Alpha Glucosidase (GAA, otherwise called Alpha Acid ... Human Lysosomal Alpha Glucosidase (GAA) ELISA Kit. ELISA Kit for the in vitro quantitative estimation of Human Lysosomal Alpha ... glucosidase inhibitors, glucosidase inhibitors drugs, glucosidase pronunciation, glucosidasen, glucosidases and galactosidases ...
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides...
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides ... Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides ... Inhibitors of alpha glucosidases prevent the trimming of oligosaccharides on certain nascent glycoproteins, including the ... Using either a model epitope, or a natural MHBs epitope, it was demonstrated that glucosidase inhibitors enhanced presentation ...
acid alpha-glucosidase
... Snapshots of Life: Lost Connections in Pompe Disease Posted on December 18th, 2014. by Dr. Francis ... Tags: acid alpha-glucosidase, BioArt 2014, FASEB, gene therapy, muscular dystrophy, Pompe disease ... Without enough of this enzyme, called acid alpha-glucosidase (GAA), glycogen can accumulate destructively in the liver, heart, ...
Subjects: alpha-Glucosidases - Digital Collections - National Library of Medicine Search Results
DailyMed - Search Results for alpha Glucosidase Inhibitors
Global Alpha Glucosidase Inhibitors - Market Analysis | Size
Global Alpha Glucosidase Inhibitors Market Forecasts By Disease Type (Type 1, Type 2) By Distribution Channel (Online ... Alpha-Glucosidase Inhibitors Market Insights. The Global Alpha-Glucosidase Inhibitors market is expected to grow at a moderate ... Alpha Glucosidase Inhibitors Market: Disease Type Insights. On the basis of disease type, the Alpha-Glucosidase Inhibitors ... Alpha Glucosidase Inhibitors Market: Share & Competitor Analysis. Some of the key players operating in the Alpha Glucosidase ...
Alpha-Glucosidase - DNA Ligase Inhibitors with Broad-Spectrum Activity
Categorized as Alpha-Glucosidase and J. and J.C.; Supervision, J.C.; Funding Acquisition, A.C. centrioles revealing centriole ... Categorized as Alpha-Glucosidase After 15 min and 72 h, IL-2 stimulated pSTAT5A (G,H) and T cells proliferation (ACF) were ... Categorized as Alpha-Glucosidase From the point of view of water structure, positive entropy was frequently taken as the ... Categorized as Alpha-Glucosidase ERKi focus on wild-type kinases, thus they will probably have a narrow therapeutic index: ...
Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship...
Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship ... In this study, the active components of Schisandra chinensis responsible for pancreatic lipase and alpha-glucosidase inhibitory ... Peak1, Peak2, Peak4, Peak6, Peak9, Peak10, Peak11, and Peak13 were responsible for alpha-glucosidase inhibitory activity, while ... The half-maximal inhibition concentration values for pancreatic lipase and alpha-glucosidase inhibition were separately ...
Alpha-glucosidase activity in four varieties of Fiji sugar cane - USP Electronic Research Repository
Novel Methods and Data Sources for Surveillance of State-Level Diabetes and Prediabetes Prevalence
Design, synthesis, ADME prediction and anti-hyperglycemic evaluation of new alkoxyimino-substituted phenyl carboxylic acids as...
... prediction and anti-hyperglycemic evaluation of new alkoxyimino-substituted phenyl carboxylic acids as potent alpha-glucosidase ... Among all the tested compounds, 102 & 105 has displayed the most potent activity against a-glucosidase with the IC50 of 142.21± ... The mode of binding interactions between the a-glucosidase enzyme and the compound 102 was established to be uncompetitive ... the inhibition activity of 102 and 105 on a-glucosidase had higher potential than a-amylase. ...
Materials | Free Full-Text | A Review on Plant-Mediated Synthesis of Bimetallic Nanoparticles, Characterisation and Their...
Lebovitz, H.E. Alpha-Glucosidase Inhibitors. Endocrinol. Metab. Clin. N. Am. 1997, 26, 539-551. [Google Scholar] [CrossRef] ... Alpha-glucosidase is an enzyme that participates in the process of digesting carbohydrates. It mediates the cleavage of ... Diabetes is the third leading cause of death worldwide after cardiovascular disease and cancer [131,132]. α-Glucosidase and α- ... Therefore, amylase and glucosidase inhibitors prevent the breakdown of carbohydrates into monosaccharides, the main reason for ...
Invokana: Side effects, dosage, alternatives, uses, and more
Intracranial Aneurysms Guide: Causes, Symptoms and Treatment Options
Microwave Assistant Synthesis of Novel Inhibitors of Lipase, Alpha-Glucosidase and Antimicrobial Activities Based on...
Pompe disease: MedlinePlus Genetics
The GAA gene provides instructions for producing an enzyme called acid alpha-glucosidase (also known as acid maltase). This ... Mutations in the GAA gene prevent acid alpha-glucosidase from breaking down glycogen effectively, which allows this sugar to ... Fukuda T, Roberts A, Plotz PH, Raben N. Acid alpha-glucosidase deficiency (Pompe disease). Curr Neurol Neurosci Rep. 2007 Jan;7 ...
MedlinePlus - Search Results for: ACARBOSE
Creator: Halvorson, Harlyn O. - Sol Spiegelman - Profiles in Science Search Results
Publication Detail
... alpha-Amylases/antagonists & inhibitors*; alpha-Amylases/chemistry; alpha-Glucosidases/chemistry ... on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. To evaluate the relative ... Title: Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. ... Results showed that grape seed extract strongly inhibited both α-amylase and α-glucosidase activity, with equal and much higher ...
Diovan (valsartan) dose, indications, adverse effects, interactions... from PDR.net
Alpha-glucosidase Inhibitors: (Moderate) Angiotensin II receptor antagonists (ARBs) may enhance the hypoglycemic effects of ... Apraclonidine: (Minor) Alpha blockers as a class may reduce heart rate and blood pressure. While no specific drug interactions ... Lurasidone: (Moderate) Due to the antagonism of lurasidone at alpha-1 adrenergic receptors, the drug may enhance the ... Ziprasidone: (Minor) Ziprasidone is a moderate antagonist of alpha-1 receptors and may cause orthostatic hypotension with or ...
MMRRC:044343-MU
1u8x.1 | SWISS-MODEL Template Library
CRYSTAL STRUCTURE OF GLVA FROM BACILLUS SUBTILIS, A METAL-REQUIRING, NAD-DEPENDENT 6-PHOSPHO-ALPHA-GLUCOSIDASE Coordinates. PDB ... 1 x G6P: 6-O-phosphono-alpha-D-glucopyranose(Non-covalent). G6P.1: 13 residues within 4Å:*. Chain A: R.111, R.118, E.134, N.172 ... Dependent Phospho-alpha-Glucosidase from Bacillus subtilis. STRUCTURE (2004) Release Date. 2004-08-24. Peptides. Maltose-6- ...
Inhibitors21
- Alpha-glucosidase inhibitors (such as acarbose) decrease the absorption of carbohydrates from the digestive tract, thereby lowering the after-meal glucose levels. (medlineplus.gov)
- Alpha glucosidase inhibitors have been shown to be effective in improving glycemic control in type 2 diabetes. (nih.gov)
- Two alpha glucosidase inhibitors have been approved for use in the United States, acarbose (Precose) in 1995 and miglitol (Glyset) in 1996. (nih.gov)
- Inhibitors of alpha glucosidases prevent the trimming of oligosaccharides on certain nascent glycoproteins, including the hepatitis B virus MHBs envelope glycoprotein. (nih.gov)
- Using either a model epitope, or a natural MHBs epitope, it was demonstrated that glucosidase inhibitors enhanced presentation by MHC class I and promoted activation of antigen-specific CTLs, suggesting a pharmacologic approach to immune modulation. (nih.gov)
- The Global Alpha-Glucosidase Inhibitors market is expected to grow at a moderate CAGR during the forecast period. (globalmarketestimates.com)
- Rise in the geriatric population in emerging economies in the Asia Pacific region is likely to further boost the market for Alpha-Glucosidase Inhibitors. (globalmarketestimates.com)
- The market for Alpha-Glucosidase Inhibitors is expected to be larger in areas with high carbohydrate consumption. (globalmarketestimates.com)
- However, Alpha-Glucosidase Inhibitors are used as a second line monotherapy treatment or are used in combination with first-line therapy drugs. (globalmarketestimates.com)
- On the basis of disease type, the Alpha-Glucosidase Inhibitors market can be segmented into type-1 and type-2 diabetes. (globalmarketestimates.com)
- Use of Alpha-Glucosidase Inhibitors is higher in the treatment of type-2 diabetes and is therefore projected to hold the higher market share in terms of revenue. (globalmarketestimates.com)
- The Global Alpha-Glucosidase Inhibitors market is segmented into Online Pharmacies, Retail Pharmacies, and Hospital Pharmacies based on the distribution channel. (globalmarketestimates.com)
- The Asia Pacific market for Alpha-Glucosidase Inhibitors is projected to grow at the highest CAGR owing to a demonstrated rise in geriatric population over the past few years along with a rise in cases of type-2 diabetes. (globalmarketestimates.com)
- The North American region is likely to hold the larger market share in the Alpha-Glucosidase Inhibitors Market owing to technological advancements and easy availability of the drug in medical facilities. (globalmarketestimates.com)
- The market for Alpha-Glucosidase Inhibitors in Central & South America is also expected to grow at a significant rate due to initiatives were taken by the Government to use advanced drugs for diabetes treatment. (globalmarketestimates.com)
- Pancreatic lipase and alpha-glucosidase inhibitors screening from Schisandra chinensis based on spectrum-effect relationship and ultra-high-performance liquid chromatography-tandem mass spectrometry. (bvsalud.org)
- Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. (nih.gov)
- Whereas tea extracts and catechin 3-gallates were less effective inhibitors of α-amylase, they were potent inhibitors of α-glucosidase. (nih.gov)
- The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of α-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit α-amylase activity. (nih.gov)
- 11. Identification of alpha-glucosidase inhibitors from a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves. (nih.gov)
- For example, pu- erh contains alpha-amylase and alpha-glucosidase inhibitors that reduce the absorption of dietary glucose and lower blood glucose levels, particularly after eating. (marksdailyapple.com)
Inhibition8
- Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. (nih.gov)
- As peptides loaded onto newly synthesized MHC class I complexes are predominantly derived from proteasomes, the possibility that glucosidase inhibition could increase presentation by MHC class I was determined. (nih.gov)
- The half-maximal inhibition concentration values for pancreatic lipase and alpha-glucosidase inhibition were separately measured by enzymatic reactions. (bvsalud.org)
- Based on the inhibition percentage, the inhibition activity of 102 and 105 on a -glucosidase had higher potential than a -amylase. (thesciencein.org)
- To evaluate the relative potency of extracts and catechins, their concentrations required for 50 and 90% inhibition of enzyme activity were determined and compared to the widely used pharmacological glucosidase inhibitor, acarbose. (nih.gov)
- 3. Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. (nih.gov)
- 13. Antidiabetic activity of lipophilic (-)-epigallocatechin-3-gallate derivative under its role of alpha-glucosidase inhibition. (nih.gov)
- The antihyperglycemic action of acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (nih.gov)
Inhibitory8
- In this study, the active components of Schisandra chinensis responsible for pancreatic lipase and alpha-glucosidase inhibitory activity were screened and identified based on a spectrum-effect relationship study in combination with ultra-performance liquid chromatography - tandem mass spectrometry analysis . (bvsalud.org)
- In an attempt to further explore the role of substituted carboxylic acid derivatives as antidiabetic agent, a series of alkoxyimino-substituted carboxylic acid derivatives ( 101-206 ) were designed, synthesized and evaluated for their inhibitory potential against a -amylase and a -glucosidase enzyme. (thesciencein.org)
- This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers (catechins) on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. (nih.gov)
- 1. alpha-Glucosidase inhibitory profile of catechins and theaflavins. (nih.gov)
- 9. alpha-Glucosidase inhibitory activity of some Sri Lanka plant extracts, one of which, Cassia auriculata, exerts a strong antihyperglycemic effect in rats comparable to the therapeutic drug acarbose. (nih.gov)
- One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity. (nih.gov)
- 2) Antidiabetic function has been attributed to α -glucosidase inhibitory activity. (stuartxchange.com)
- Study showed the methanolic extract from the stems of Salacia chinensis showed potent anti-hyperglycemic effects in oral sucrose or maltose-loaded rats, inhibitory effects on intestinal α-glucosidase, rat lens aldose reductase and radical scavenging activities. (stuartxchange.com)
Enzyme13
- Alpha glucosidase is an intestinal brush border enzyme responsible for the hydrolysis of disaccharides which is necessary for the absorption of starch, dextrins and disaccharides. (nih.gov)
- Without enough of this enzyme, called acid alpha-glucosidase (GAA), glycogen can accumulate destructively in the liver, heart, and skeletal muscles, making it increasingly difficult to walk, eat, and even breathe. (nih.gov)
- The mode of binding interactions between the a -glucosidase enzyme and the compound 102 was established to be uncompetitive using kinetic analysis. (thesciencein.org)
- The GAA gene provides instructions for producing an enzyme called acid alpha-glucosidase (also known as acid maltase). (nih.gov)
- Pompe disease is a rare, inherited disorder characterized by the deficiency of an enzyme called acid alpha-glucosidase (GAA). (nih.gov)
- glucosidase as adjuvant enzyme(s) for .alpha. (justia.com)
- glucosidase as an adjuvant enzyme needs to immediately decompose the maltooligosaccharide produced by .alpha. (justia.com)
- When the enzyme is kept in contact with a substrate for a long period of time, the enzyme gradually acts on the substrate, for which reason the reagent containing the enzyme and a substrate need to be used immediately for the determination of .alpha. (justia.com)
- This method is advantageous in that the substrate is not attacked by an adjuvant enzyme before the action of .alpha. (justia.com)
- Accordingly, reagents are still usable upon long-term storage after preparation of reagents containing the enzyme and the substrate, enabling preparation of a single-vial reagent containing enzyme(s) and substrate(s) for the determination of .alpha. (justia.com)
- A genetic deficiency or lysosomal enzyme acid alpha-glucosidase (GAA) dysfunction causes Pompe disease. (pharmaceutical-technology.com)
- Pompe disease is a genetic disease that occurs when a specific enzyme (acid alpha-glucosidase) is absent or the body doesn't produce enough. (dukehealth.org)
- These tests look for the presence of a key enzyme -- acid alpha-glucosidase - as well as the buildup of glycogen in muscle and tissues in the body. (dukehealth.org)
Glycogen3
- Lysosomal Alpha Glucosidase (GAA, otherwise called Alpha Acid-Glucosidase) is a catalyst that corrupts glycogen into glucose. (phrconference.org)
- Mutations in the GAA gene prevent acid alpha-glucosidase from breaking down glycogen effectively, which allows this sugar to build up to toxic levels in lysosomes. (nih.gov)
- Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II . (nih.gov)
Deficiency1
- Fukuda T, Roberts A, Plotz PH, Raben N. Acid alpha-glucosidase deficiency (Pompe disease). (nih.gov)
Acarbose3
- Among all the tested compounds, 102 & 105 has displayed the most potent activity against a -glucosidase with the IC 50 of 142.21±1.8 mM and 182.83±2.43 mM respectively, as compared to the standard drug acarbose (136.89±1.67 mM). (thesciencein.org)
- Results showed that grape seed extract strongly inhibited both α-amylase and α-glucosidase activity, with equal and much higher potency, respectively, than acarbose. (nih.gov)
- Acarbose Tablets are an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. (nih.gov)
Intestinal1
- Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. (nih.gov)
Lysosomal1
- ELISA Kit for the in vitro quantitative estimation of Human Lysosomal Alpha Glucosidase (GAA) focuses in tissue homogenates, cell lysates and other natural liquids. (phrconference.org)
Glucose7
- Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. (nih.gov)
- amylase substrate and optically determining a liberated label, the substrate being a maltooligosaccharide composed of at least 3 glucose units, whose reducing terminal glucose is bonded to an optically measurable label at the 1-position by .alpha. (justia.com)
- glucoside linkage, and whose non-reducing terminal glucose is modified by a substituent other than glucose, and the .alpha. (justia.com)
- glucosidase being substantially capable of acting on glucose to which the label is bonded at the 1-position by .alpha. (justia.com)
- Amylase activity has hitherto been determined by using a maltooligosaccharide having an unmodified non-reducing terminal glucose and .alpha. (justia.com)
- glucosidase also acts on maltooligosaccharides whose reducing terminal glucose is bonded to a label, but scarcely acts on maltooligosaccharides having a glucose chain length equal to or longer than that of maltotetraose (G4), it acts very slowly on maltooligosaccharides having a chain length not less than G4 and unmodified non-reducing terminal glucose prior to the action of .alpha. (justia.com)
- glucosidase originated from yeast, however, exhibits lowered activity as the glucose chain becomes longer. (justia.com)
Pancreatic1
- amylase activity in body fluid, which is a clinical parameter in the diagnoses of pancreatic diseases and sialadenotropic diseases, and to reagents for the determination of .alpha. (justia.com)
Activity2
- amylase activity which involves bringing a sample into contact with an .alpha. (justia.com)
- amylase activity comprising the .alpha. (justia.com)
Presence1
- glucosidase in the presence of an .alpha. (justia.com)
Analysis1
- Comparative analysis among fully sequenced Dyella species indicate that the genome synteny is not conserved, and that D. jiangningensis FCAV SCS01 carries 372 unique genes, including an alpha-glucosidase and maltodextrin glucosidase coding genes, and other potential biomass degradation related genes. (mendeley.com)
Beta1
- glucosidase and, if necessary, .beta. (justia.com)
Method5
- US Patent for Method for determination of .alpha. (justia.com)
- Method for determination of .alpha. (justia.com)
- A method for determining .alpha. (justia.com)
- The present invention relates to a method for the determination of .alpha. (justia.com)
- Nonetheless, this method also poses problems of specificity of .alpha. (justia.com)
Structure1
- Novel Catalytic Mechanism of Glycoside Hydrolysis Based on the Structure of an NAD(+)/Mn(2+)-Dependent Phospho-alpha-Glucosidase from Bacillus subtilis. (expasy.org)
Sensitive1
- glucosidase for a substrate, and for a sensitive determination to be conducted by an efficient adjuvant reaction, it is required to add a large excess of .alpha. (justia.com)
Lysosomal2
Acid3
- Many of these mutations change one of the protein building blocks (amino acids) used to make acid alpha-glucosidase. (nih.gov)
- Fukuda T, Roberts A, Plotz PH, Raben N. Acid alpha-glucosidase deficiency (Pompe disease). (nih.gov)
- Yan B, Raben N, Plotz P. The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway. (nih.gov)
Catechins2
- This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers (catechins) on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. (nih.gov)
- 1. alpha-Glucosidase inhibitory profile of catechins and theaflavins. (nih.gov)
Gene1
- Genomic organization and promoter activity of glucosidase I gene. (nih.gov)
