Cyclodextrins: A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.alpha-Cyclodextrins: Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.gamma-Cyclodextrins: Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.DextrinsTrimeprazine: A phenothiazine derivative that is used as an antipruritic.Rotaxanes: Complex compounds in which a dumbbell shaped molecule is encircled by a macrocycle. They are named after rota (wheel) and axis (axle). Notation with a prefix is used to indicate the number of interlocked components. They have potential use in NANOTECHNOLOGY. Rotaxanes have been made with CYCLODEXTRINS and CYCLIC ETHERS.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Starch: Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Micromonosporaceae: A family of gram-positive, saprophytic bacteria occurring in soil and aquatic environments.Optical Rotation: The rotation of linearly polarized light as it passes through various media.Sun Protection Factor: A measure of relative protection provided by SUNSCREENING AGENTS against burns due to ultraviolet (UV) radiation from a light source.alpha-Amylases: Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and related POLYSACCHARIDES and OLIGOSACCHARIDES containing 3 or more 1,4-alpha-linked D-glucose units.Myristates: Salts and esters of the 14-carbon saturated monocarboxylic acid--myristic acid.Glucan 1,4-alpha-Glucosidase: An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of polysaccharide chains with the release of beta-glucose. It is also able to hydrolyze 1,6-alpha-glucosidic bonds when the next bond in sequence is 1,4.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Glucosyltransferases: Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Acarbose: An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Glycoside HydrolasesSolutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Hydrophobic and Hydrophilic Interactions: The thermodynamic interaction between a substance and WATER.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Spectrometry, Mass, Fast Atom Bombardment: A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Kinetics: The rate dynamics in chemical or physical systems.Bacillus: A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic.

Properties of a cyclodextrin-specific, unusual porin from Klebsiella oxytoca. (1/76)

The function of CymA, 1 of the 10 gene products involved in cyclodextrin uptake and metabolism by Klebsiella oxytoca, was characterized. CymA is essential for growth on cyclodextrins, but it can also complement the deficiency of a lamB (maltoporin) mutant of Escherichia coli for growth on linear maltodextrins, indicating that both cyclic and linear oligosaccharides are accepted as substrates. CymA was overproduced in E. coli and purified to apparent homogeneity. CymA is a component of the outer membrane, is processed from a signal peptide-containing precursor, and possesses a high content of antiparallel beta-sheet. Incorporation of CymA into lipid bilayers and conductance measurements revealed that it forms ion-permeable channels, which exhibit a substantial current noise. CymA-induced membrane conductance decreased considerably upon addition of alpha-cyclodextrin. Titration experiments allowed the calculation of a half-saturation constant, K(S), of 28 microM for its binding to CymA. CymA assembled in vitro to two-dimensionally crystalline tubular membranes, which, on electron microscopy, are characterized by a p1-related two-sided plane group. The crystallographic unit cell contains four monomeric CymA molecules showing a central pore. The lattice parameters are a = 16.1 nm, b = 3.8 nm, gamma = 93 degrees. CymA does not form trimeric complexes in lipid membranes and shows no tendency to trimerize in solution. CymA thus is an atypical porin with novel properties specialized to transfer cyclodextrins across the outer membrane.  (+info)

Enzymatic synthesis of N-acetylglucosaminyl-cyclodextrin by the reverse reaction of N-acetylhexosaminidase from jack bean. (2/76)

Novel heterobranched cyclodextrins (CDs), N-acetylglucosaminyl-cyclodextrins (GlcNAc-CD), were synthesized from a mixture of GlcNAc and alpha, beta, or gamma CD by the reverse reaction of N-acetylhexosaminidase from jack bean. Optimum pH and temperature for the production of GlcNAc-alpha CD by N-acetylhexosaminidase were pH 4.9 and 50-70 degrees C, respectively. The maximum yield of GlcNAc-alpha CD was 17.5% (mol/mol) at the concentration of 1 M GlcNAc and 0.25 M alpha CD. The reverse reaction product, GlcNAc-alpha CD, was separated into two peaks by HPLC analysis on the ODS column. Their structures were identified as 6-O-beta-D-N-acetylglucosaminyl-alpha CD and 2-O-beta-D-N-acetylglucosaminyl-alpha CD by FAB-MS and NMR spectroscopies. N-Acetylhexosaminidase from jack bean also synthesized N-acetylgalactosaminyl-alpha CD from N-acetylgalactosamine and alpha CD.  (+info)

Probing protein-sugar interactions. (3/76)

We have investigated the partial specific volumes (2) (ml/g), hydration, and cosolvent interactions of rabbit muscle aldolase by equilibrium sedimentation in the analytical ultracentrifuge and by direct density increment (partial differential/partial differentialc(2))(mu) measurements over a range of sugar concentrations and temperature. In a series of sugars increasing in size, glucose, sucrose, raffinose, and alpha-cyclodextrin, (partial differential/ partial differentialc(2))(mu) decreases linearly with the solvent density rho(0). These sugar cosolvents do not interact with the protein; however, the interaction parameter B(1) (g water/g protein) mildly increases with increasing sugar size. The experimental B(1) values are smaller than values calculated by excluded volume (rolling ball) considerations. B(1) relates to hydration in this and in other instances studied. It decreases with increasing temperature, leading to an increase in (2) due to reduced water of hydration electrostriction. The density increments (partial differential/ partial differentialc(2))(mu), however, decrease in concave up form in the case of glycerol and in concave down form for trehalose, leading to more complex behavior in the case of carbohydrates playing a biological role as osmolytes and antifreeze agents. A critical discussion, based on the thermodynamics of multicomponent solutions, is presented.  (+info)

alpha-cyclodextrin extracts diacylglycerol from insect high density lipoproteins. (4/76)

alpha-Cyclodextrins are water-soluble cyclic hexamers of glucose units with hydrophobic cavities capable of solubilizing lipophiles. Incubating alpha-cyclodextrin with high density lipophorin from Manduca sexta or Bombyx mori resulted in a cloudy, turbid solution. Centrifugation separated a pale yellowish precipitate. Thin-layer chromatography analysis of the lipid extract of the precipitate showed that the major lipid was diacylglycerol, while KBr density gradient analysis of the supernatant demonstrated the presence of a lipid-depleted very high density lipophorin. Transfer of diacylglycerol from lipophorin to cyclodextrin was specific to alpha-cyclodextrin and was not observed with beta- or gamma-cyclodextrins. pH had no effect on diacylglycerol transfer to alpha-cyclodextrin. However, the transfer was strongly dependent on the concentration of alpha-cyclodextrin and temperature. Increasing the concentration of alpha-cyclodextrin in the incubation mixture was associated with the formation of increasingly higher density lipophorins. Thus, at 20, 30, and 40 mm alpha-cyclodextrin, the density of B. mori lipophorin increased from 1.107 g/ml to 1.123, 1. 148, and 1.181 g/ml, respectively. At concentrations greater than 40 mm, alpha-cyclodextrin had no further effect on the density of lipophorin. alpha-Cyclodextrin removed at most 83;-87% of the diacylglycerol present in lipophorin. Temperature played an important role in altering the amount of diacylglycerols transferred to alpha-cyclodextrin. At 30 mm alpha-cyclodextrin, the amount of diacylglycerol transferred at different temperatures was 50% at 4 degrees C, 41% at 15 degrees C, 20% at 28 degrees C, and less than 3% at 37 degrees C. We propose that diacylglycerol transfers to alpha-cyclodextrin via an aqueous diffusion pathway and that the driving force for the transfer is the formation of an insoluble alpha-cyclodextrin-diacylglycerol complex.  (+info)

Cyclodextrin encapsulation to prevent the loss of l-menthol and its retention during drying. (5/76)

The taste and flavor of spray-dried powdered products are the most important quality factors. In the present study, molecular encapsulation in cyclodextrin was applied to prevent the loss of a hydrophobic flavor compound (l-menthol) during the drying of a droplet. beta-Cyclodextrin appeared to be a better encapsulant for menthol than alpha- and gamma-cyclodextrin. The retention of menthol increased with increasing concentration of both cyclodextrin and maltodextrin. A simple mathematical model is proposed for estimating the flavor retention. The theoretical results by this model estimated well the final retention of menthol encapsulated in a blend of beta-cyclodextrin and maltodextrin.  (+info)

Mechanism of porcine pancreatic alpha-amylase. Inhibition of amylose and maltopentaose hydrolysis by alpha-, beta- and gamma-cyclodextrins. (6/76)

The effects of alpha-, beta- and gamma-cyclodextrins on the amylose and maltopentaose hydrolysis catalysed by porcine pancreatic alpha-amylase (PPA) were investigated. The results of the statistical analysis performed on the kinetic data using the general initial velocity equation of a one-substrate reaction in the presence of one inhibitor indicate that the type of inhibition involved depends on the substrate used: the inhibition of amylose hydrolysis by alpha-, beta- and gamma-cyclodextrin is of the competitive type, while the inhibition of maltopentaose hydrolysis is of the mixed noncompetitive type. Consistently, the Lineweaver-Burk plots intersect on the vertical axis when amylose is used as the substrate, while in the case of maltopentaose, the intersection occurs at a point located in the second quadrant. The inhibition of the hydrolysis therefore involves only one abortive complex, PPA-cyclodextrin, when amylose is used as the substrate, while two abortive complexes, PPA-cyclodextrin and PPA-maltopentaose-cyclodextrin, are involved with maltopentaose. The mixed noncompetitive inhibition thus shows the existence of one accessory binding site. In any case, only one molecule of inhibitor binds to PPA. In line with these findings, the difference spectra of PPA produced by alpha-, beta- and gamma-cyclodextrin indicate that binding occurs at a tryptophan and a tyrosine residue. The corresponding dissociation constants and the inhibition constants obtained using the kinetic approach are in the same range (1.2-7 mM). The results obtained here on the inhibition of maltopentaose hydrolysis by cyclodextrin are similar to those previously obtained with acarbose as the inhibitor [Alkazaz, M., Desseaux, V., Marchis-Mouren, G., Prodanov, E. & Santimone, M. (1998) Eur. J. Biochem. 252, 100-107], but differ from those obtained with amylose as the substrate and acarbose as inhibitor [Alkazaz, M., Desseaux, V., Marchis-Mouren, G., Payan, F., Forest, E. & Santimone, M. (1996) Eur. J. Biochem. 241, 787-796]. It is concluded that the hydrolysis of both long and short chain substrates requires at least one secondary binding site, including a tryptophan residue.  (+info)

Fluorescence enhancement of coumarin-6-sulfonyl chloride amino acid derivatives in cyclodextrin media. (7/76)

Coumarin-6-sulfonyl (6-CS) amino acid derivatives form inclusion complexes with a- and /-cyclodextrins (CD) in aqueous solution. The stoichiometry of the inclusion complex and the equilibrium constant were investigated. Using a fluorescence technique and alanine-beta-CD as a model, a 1:2 guest-host complex was established, and K = 4.7 x 10(5) mol(-2) l(2) was obtained. Fluorescence enhancement was observed for all derivatives studied, with glycine exhibiting a greater enhancement, and tyrosine showing the least. The stability of the inclusion complex was found to depend on the respective sizes of the guest-host complex and their interaction.  (+info)

Pharmacokinetics and pharmacodynamics of human chorionic gonadotropin (hCG) after rectal administration of hollow-type suppositories containing hCG. (8/76)

To determine the effectiveness of human chorionic gonadotropin (hCG) administered rectally, we studied the pharmacokinetics and pharmacodynamics of hCG using a hollow-type suppository. HCG was not detected in plasma when only hCG was administered rectally, even at a higher dose (4,000 IU/kg body weight) than intravenous injection, because of its low bioavailability due to high molecular weight or degradation by proteolytic activity. To enhance the rectal absorption of hCG, the effectiveness of its coadministration with alpha-cyclodextrin (alpha-CyD), an absorption-enhancing agent, was investigated in male rabbits. HCG was detected in plasma following coadministration of hCG and alpha-CyD (10 mg/kg body weight) into the rectum. The plasma hCG concentration increased with increasing dose of alpha-CyD. The AUC(0-48) observed after coadministration of hCG and alpha-CyD at 30 mg/kg body weight was approximately four times higher than that of hCG and alpha-CyD at 10mg/kg body weight. HCG at a high concentration induced a rapid increase in the plasma testosterone concentration (74.2 +/- 3.4 ng/ml) 2 h after intravenous administration. However, the testosterone concentration 24 h after intravenous administration decreased to the physiological level (approximately 20 ng/ml) which had been observed before such administration. On the other hand, the maximum level of testosterone concentration (40.0 +/- 12.6 ng/ml) was observed 24 h after rectal administration of hCG (400 IU/kg body weight) in combination with alpha-CyD (30 mg/kg body weight). Moreover, the plasma testosterone concentration (31.0 +/- 11.4 ng/ml) obtained 72 h after rectal administration tended to be maintained at a higher level than that (14.4 +/- 0.9ng/ml) observed before the administration. These results suggest that the hollow-type suppository as a rectal delivery system of hCG is promising as a new mode of hCG therapy.  (+info)

*Alpha-Cyclodextrin

... (α-dextrin, α-cyclodextrin, α-CD, alphadextrin, alpha cyclodextrin (dietary fiber)) is a polysaccharide of ... Tests showed that alpha cyclodextrins can cause a volume effect in various different food compositions with or without fat and ... Unlike lipase inhibitors, alpha-cyclodextrin forms a stable complex with the dietary fat which prevents lipase from digesting ... This fiber is sold under the brand names, "Alpha-Fibe" and "Calorease". Alpha-Fibe is the original product that contains this ...

*Cyclodextrin

GRN 000155, alpha-cyclodextrin GRAS Notice No. GRN 000074, beta-cyclodextrin GRAS Notice No. GRN 000046, gamma-cyclodextrin ... Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the FDA. In the food industry, cyclodextrins are ... alpha)-cyclodextrin: 6-membered sugar ring molecule β (beta)-cyclodextrin: 7-membered sugar ring molecule γ (gamma)- ... Weight loss supplements are marketed from alpha-cyclodextrin which claim to bind to fat and be an alternative to other anti- ...

*Inhaled ciclosporin

Fukaya, H; Iimura, A; Hoshiko, K; Fuyumuro, T; Noji, S; Nabeshima, T (Aug 2003). "A cyclosporin A/maltosyl-alpha-cyclodextrin ...

*Dansyl chloride

The fluorescence of these sulfonamide adducts can be enhanced by adding alpha-cyclodextrin. Dansyl chloride is unstable in ...

*Gold cyanidation

... liquid mercury and alpha-cyclodextrin. Challenges include reagent cost and the efficiency of gold recovery. Thiourea has been ...

*Glycoside hydrolase family 14

Two maltose molecules also bind in the cleft, one sharing a binding site with alpha-cyclodextrin, and the other sitting more ... The 3D structure of a complex of soybean beta-amylase with an inhibitor (alpha-cyclodextrin) has been determined to 3.0A ... beta alpha)8 fold. The interface of the two domains, together with shorter loops from the (beta alpha)8 core, form a deep cleft ... preliminary chain tracing of the complex with alpha-cyclodextrin". J. Biochem. 112 (4): 541-546. PMID 1491009. This article ...

*Supramolecular polymers

Self-assembled supramolecular hydrogels formed by biodegradable PEO-PHB-PEO triblock copolymers and alpha-cyclodextrin for ... By combining ferrocene dimer with β-cyclodextrin dimer, Aredox-control supramolecular polymers system has been proposed as a ...

*Cucurbituril

Mono-, Oligo- und Polyrotaxane mit Cucurbituril und gemischte Polyrotaxane mit Cucurbituril und alpha-Cyclodextrin mittels ... U.S. Patent 6,365,734 The complex formation of a, w-dicarboxylic acids and a, w-diols with cucurbituril and a-cyclodextrin. the ... Other common molecular capsules that share a similar molecular shape with cucurbiturils include cyclodextrins, calixarenes, and ...

*Supramolecular catalysis

... hydrolysis of m-tert-butylphenyl acetate is accelerated in the presence of 2-benzimidazoleacetic acid and alpha-cyclodextrin, ... developed a catalyst based on a beta-cyclodextrin carrying two imidazole groups. This cyclodextrin catalytic system mimics ... Cyclodextrins have rigid ring structure, hydrophilic surface, and hydrophobic cavity on the inside; therefore, they are capable ... From the early 1970s, cyclodextrins have been extensively studied for its encapsulation properties and used as binding sites in ...

*List of MeSH codes (D09)

... cyclodextrins MeSH D09.698.365.855.400.375.222 --- alpha-cyclodextrins MeSH D09.698.365.855.400.375.333 --- beta-cyclodextrins ... MeSH D09.698.365.855.400.375.444 --- gamma-cyclodextrins MeSH D09.698.365.855.500 --- hetastarch MeSH D09.698.365.855.750 --- ...

*List of MeSH codes (D04)

... alpha-cyclodextrins MeSH D04.345.103.333 --- beta-cyclodextrins MeSH D04.345.103.444 --- gamma-cyclodextrins MeSH D04.345. ... 17-alpha-hydroxyprogesterone MeSH D04.808.745.745.654.829.614 --- medroxyprogesterone MeSH D04.808.745.745.654.829.614.500 --- ... 5-alpha-dihydroprogesterone MeSH D04.808.745.558.050 --- alfaxalone alfadolone mixture MeSH D04.808.745.558.783 --- ... 20-alpha-dihydroprogesterone MeSH D04.808.745.745.654.829.395 --- hydroxyprogesterones MeSH D04.808.745.745.654.829.395.400 ...

*Wolfram Saenger

Water Molecule in Hydrophobic Surroundings: Structure of alpha-Cyclodextrin-Hexahydrate (C6H10O5)66H2O, Nature, 1972 Circular ...

*Cyclodextrin glycosyltransferase

Rational design of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 to increase alpha-cyclodextrin ... Cyclodextrin glycosyl transferase (also Cyclodextrin glucosyltransferase or Cyclodextrin glucanotransferase) or CGTase for ... The coupling reaction can be easily described as the reverse process of cyclization: the enzyme cleaves a cyclodextrin to ... Disproportionation is very similar to coupling, but the cleaved dextrin is not a cyclodextrin, but a linear oligosaccharide ...

*Coordination sphere

"Selective isolation of gold facilitated by second-sphere coordination with alpha-cyclodextrin" Nature Communications 2013, 4, ... Macrocyclic molecules such as cyclodextrins act often as the second coordination sphere for metal complexes. Coordination ...

*Inclusion compound

alpha-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ... Cyclodextrin also forms inclusion compounds with fragrance molecules.[5] As a result, the fragrance molecules have a reduced ... Inclusion complexes are formed between cyclodextrins and different guest molecules[1][2][3] such as ferrocene.[4] When a ... cyclodextrin-ferrocene in the solid state Yu Liu, Rui-Qin Zhong, Heng-Yi Zhang and Hai-Bin Song Chemical Communications, 2005 ...

*Cyclomaltodextrin glucanotransferase

... alpha-cyclodextrin glucanotransferase, alpha-cyclodextrin glycosyltransferase, beta-cyclodextrin glucanotransferase, beta- ... The systematic name of this enzyme class is 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing). Other ... cyclodextrin glycosyltransferase, gamma-cyclodextrin glycosyltransferase, cyclodextrin glycosyltransferase, cyclomaltodextrin ... 4-alpha-D-glucan molecule through the formation of a 1,4-alpha-D-glucosidic bond. This enzyme belongs to the family of ...

*Synthetic ion channels

... as supramolecular or covalent bonding of cyclodextrins to alpha-hemolysin demonstrates. An ion channel can be characterized by ... Other substituted β-cyclodextrins have since been reported, including thiol-modified cyclodextrins, an anion-selective ... Chui, J. K. W.; Fyles, T. M. (May 2010). "Apparent fractal distribution of open durations in cyclodextrin-based ion channels". ... The first synthetic ion channel was constructed by partial substitution on the primary rim of β-cyclodextrin. ...

*Hemolysin

At the moment, apiegnin and beta-cyclodextrin are thought to alleviate S.aureus pneumonia, whereas the antibodies of anti alpha ... In this case, it has been proven that alpha-hemolysin takes part in inducing necrotic pulmonary injury by the use of the NLRP3 ... This pore consists of seven alpha-hemolysin subunits, which represent the major cytotoxic agent that is freed by this kind of ... Alpha-hemolysin from Staphylococcus aureus can cause severe diseases, such as pneumonia. Aerolysin from Aeromonas sobria ...

*Dextrin

Cyclodextrin The cyclical dextrins are known as cyclodextrins. They are formed by enzymatic degradation of starch by certain ... Alpha) Limit dextrin is a short chained branched amylopectin remnant, produced by hydrolysis of amylopectin with alpha amylase ... that can be produced by enzymatic hydrolysis of the alpha-1,6 glycosidic bonds or debranching amylopectin. Amylodextrin colors ... which cannot hydrolyse the alpha-1,6 bonds at branch points. ( ... Cyclodextrins have toroidal structures formed by 6-8 glucose ...

*Glycoside hydrolase family 13

The maltogenic alpha-amylase is an enzyme which catalyses hydrolysis of (1-4)-alpha-D-glucosidic linkages in polysaccharides so ... which hydrolyses cyclodextrins. Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic ... as to remove successive alpha-maltose residues from the non-reducing ends of the chains in the conversion of starch to maltose ...

*Cycloamylose

Chemically they are similar to the much smaller cyclodextrins, which are typically composed of 6, 7 or 8 glucose units. ... Takaha, T.; Yanase, M.; Okada, S.; Smith, S. M. (1993-01-15). "Disproportionating enzyme (4-alpha-glucanotransferase; EC 2.4. ... While the structures of cyclodextrins are planar circles, the structure of cycloamyloses with 10 to 14 glucose units were ... "Structures of the Common Cyclodextrins and Their Larger AnaloguesBeyond the Doughnut". Chemical Reviews. 98 (5): 1787-1802. doi ...

*List of biomolecules

Cortisol Creatine Creatine kinase Crystallin α-Cyclodextrin Cyclodextrin glycosyltransferase Cyclopamine Cyclopiazonic acid ... see Alpha-amanitin Amino acid Amylase (also see α-amylase) Anabolic steroid Anethole Angiotensinogen Anisomycin Antidiuretic ... Aequorin Aflatoxin Agar Alamethicin Alanine Albumins Aldosterone Aleurone Alpha-amanitin Allantoin Allethrin α-Amanatin, ...

*List of food additives

Carotenes - color Alpha-carotene - color Beta-carotene - color Gamma-carotene - color Carrageenan - thickener, vegetable gum, ... artificial sweetener beta-cyclodextrin - emulsifier Lemongrass (Cymbopogon citratus, C. flexuosus, and other species) - Damiana ... antioxidant Dl-alpha-tocopherol (synthetic) - antioxidant Dodecyl gallate - antioxidant Echinacea - EDTA - Antioxidant, ...

*Itraconazole

The cyclodextrin contained in the oral solution can cause an osmotic diarrhea, and if this is a problem, then half the dose can ... These distinct activities are unrelated to inhibition of the cytochrome P450 lanosterol 14 alpha-demethylase and the exact ... sometimes fatal The cyclodextrin used to make the syrup preparation can cause diarrhea. Side effects that may indicate a ... be given as oral solution and half as capsule to reduce the amount of cyclodextrin given. "Sporanox" itraconazole capsules ...

*Joint FAO/WHO Expert Committee on Food Additives

The first part deals with food additives such as benzyol peroxide, cyclodextrin, hexose oxidase, lutein, hydroxy ethylidine-1, ... alpha-acetolactate decarboxylase and maltogenic amylase), one flavoring agent (trans-anethole), one glazing agent (hydrogenated ...

*Glycogen branching enzyme

4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase. Other names in common use include branching ... cyclodextrin glucanotransferase (CGT), and branching enzyme. Shown by x-ray crystallography, glycogen branching enzyme has four ... 4-alpha-glucan branching enzyme, plant branching enzyme, alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase, and starch ... Buisson, G; Duee, E; Haser, R; Payan, F (December 20, 1987). "Three dimensional structure of porcine pancreatic alpha-amylase ...
alpha-Cyclodextrin (α-dextrin, α-cyclodextrin, α-CD, alphadextrin, alpha cyclodextrin (dietary fiber)) is a polysaccharide of six glucose units that are covalently attached end to end via α-1, 4 linkages. This fiber is sold under the brand names, "Alpha-Fibe" and "Calorease". Alpha-Fibe is the original product that contains this unique fiber, introduced to the worldwide nutritional supplement market by Bio-Form Essentials in 2007. Soho Flordis International became the patent Assignee as of March 30, 2012 and launched the brand Calorease in 2013. FBCx is not an ingredient, only an abbreviation, and is not part of the scientific name. The abbreviation FBCx, stands for "Fat Binding Complexer" and can be associated with the brand names, "Alpha-Fibe" and "Calorease". There are two other naturally occurring cyclodextrins, β (beta) - and γ (gamma) -, which contain seven and eight glucose units respectively. In water, these fibers take on a toroid or truncated cone configuration. In aqueous ...
[Product Name] alpha-Cyclodextrin [Synonyms] alpha-Schardinger dextrin Cyclohexaamylose [CAS] 10016-20-3 [Formula] C36H60O30 [Molecular Weight] 972.86 [EINECS] 233-007-4 [RTECS] GU2292000 [RTECS Class] Other [Merck] 13,2747 [Beilstein/Gmelin]...
Patients with advanced cirrhosis often develop a hyperdynamic circulation with central hypovolaemia. The events that initiate the systemic haemodynamic abnormalities and the coupling of these factors to splanchnic haemodynamics are still unclear. Objective On the basis of a large population of patients with cirrhosis to identify splanchnic and clinical characteristics associated with the development of the hyperdynamic circulation and survival ...
3L2M: X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin.
article{846db9be-cde0-4c61-ad98-3a878883f3ac, abstract = {Dodecyl glucooligosides, a class of interesting non ionic surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin (alpha-CD) or soluble starch as glycosyl donor and dodecyl beta-D-glucoside (C(12)G(1)) or dodecyl beta-D-maltoside (C(12)G(2)) as acceptor substrates. The primary coupling products obtained in the respective reactions were identified as dodecyl glucoheptaoside and dodecyl maltooctaoside by mass spectrometry. Higher yields of coupling products were obtained using alpha-CD as donor, while more dispoportionation occurred with starch. Nearly 78% conversion of the acceptor substrate C(12)G(1) into dodecyl glucooligosides could be achieved at 132 mu g/ml of CGTase in 20 min, while 93% of C(12)G(2) could be transformed into products at 17.6 mu g/ml of enzyme in 120 min using soluble starch as donor substrate. For applications requiring pure compounds like ...
Three conformationally preorganised host molecules based on the [3]polynorbornyl framework and incorporating di-urea receptors were synthesised and their interaction with a series of anions investigated by 1H NMR spectroscopy. A high affinity of each host molecule for dihydrogenphosphate (H2PO4-) and dihydrogenpyrophosphate (H2P2O72-) was identified. In addition to binding to the urea receptors of the host molecules, evidence for an interaction involving the non-polar C-H groups within the binding cavity of the framework and guest anions was also discovered. Furthermore, an unusual 2 : 1 host-to-anion stoichiometry was indicated when binding H2P2O72-, and a model for the anion-mediated self-assembly of this complex species is proposed ...
Incorporates a phase consisting of a 2,6-di-O-pentyl-3-trifluoroacetyl derivative of alpha-cyclodextrin. Exhibits high selectivity for oxygen containing analytes in the form of alcohols, ketones, acids, aldehydes, and lactones. Highly selective for halogenated compounds.
A chain superstructure is formed (bundles of needles) is formed during rapid co-precipitation of alpha-cyclodextrin (cyclic starch w/ glucose) and KAuBr4 in ...
SFX-01 is a synthetic version of the naturally occurring compound sulforaphane, which has been stabilised in an alpha-cyclodextrin lattice. Evgen Pharma is currently conducting two Phase II trials of SFX-01, one in advanced breast cancer and one in a type of stroke called subarachnoid haemorrhage.. The patent granted today, which covers the manufacturing and scale-up of SFX-01, marks the first patent to be granted for SFX-01 in Europe, where a composition of matter patent is also pending. Todays patent grant marks the Companys eighth patent to be granted this year, reflecting the growth in the Companys patent estate.. The European patent, numbered EP2854861 and entitled Method of Synthesising Sulforaphane, can be viewed at this link: https://register.epo.org/application?number=EP13726846&tab=doclist. The patent runs until May 2033.. This core manufacturing patent has already been granted in the United States, Australia and Japan and is pending in other countries worldwide.. Evgen Pharma holds ...
COMMUNICATIONS (C;imhridge Skieoscm 250 M3). The density of the synthesized material ({I = 2.47 gcni I ) was determined with the suspension method using butyl acetate and broinoforni as suspension liquids N M R experiments were carried out on a Bruker ASX 400 spectrometer at 79.495 MHz for Si. Received: July 2. 1994 [Z7092IE] German version: Arrgm.. C,iwi. 1995. 107. 12.5 - Keywords: silicon compounds structure elucidation zeolites zinc compounds bonds results in the specific and enthalpicallq strong binding of the anionic guest ion.[5.61 In order to mimic this natural binding principle we designed the artificial hosts 1 and 2. By virtue of the electrostatic repulsion of the inner cationic centers these molecules are inclined to adopt inflated conformations with cavities which may encapsu- - 111 J. V Smith. ~ / 7 ~ 1 ? 7Reij. . 1988. 8. 149. (21 (3 0. Brunner. W. M. Meier. Nurure 1989. 337, 146. [3] S . Merlino. tur. J Minrrul. 1990. 2,809. [4] M. J. Anncn. M . E. Davis. J. B. Higgins. J. L. ...
The body defences have evolved in such a way that they can deal with any conceivable kind of foreign material that enters the biological system, including bacteria, viruses and particles. The foreign surface is coated with host molecules present at portals of entry. These host molecules act in several ways. Some are opsonins and following binding to particle surfaces, they are recognised by defence cells, which possess receptors for them, resulting in phagocytosis and clearance e.g. scavenger receptors. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles (Arredouani et al. 2004). Proteins of the complement system bind to foreign surfaces. This results in a cascade of effects including production of opsonins and induction of inflammation. The complement system can also be involved in the response to some dusts (Warheit et al. 1991). Immunoglobulins are present in serous fluids at portals of entry. IgG is an opsosin that was found to ...
The absolute configuration and structure of aegelinol, a pyranocoumarin isolated from Ferulago asparagifolia Boiss (Apiaceae), has been determined by crystallography. Crystal structure of the inclusion complex of aegelinol in β-cyclodextrin was determined (a = 15.404(1) Å, b = 15.281(1) Å, c = 17.890(1) Å, α = 99.662(1), β = 113.4230(1), γ = 102.481(1)°, P1; R1 = 6.71%) and allowed unambiguous determination of the absolute configuration of the stereogenic center of aegelinol. The pyranocoumarin guest is included within the cylindrical cavity formed by dimeric β-cyclodextrin molecules with a head-to-head arrangement. Crystal structure of aegelinol alone was also determined (a = 6.8921(3) Å, b = 11.4302(9) Å, c = 44.964(3) Å, P212121; R1 = 4.44%) and allowed precise determination of its geometry. Aegelinol crystallizes with three molecules in the asymmetric unit held together by H-bonds and π-stacking interactions.
The absolute configuration and structure of aegelinol, a pyranocoumarin isolated from Ferulago asparagifolia Boiss (Apiaceae), has been determined by crystallography. Crystal structure of the inclusion complex of aegelinol in β-cyclodextrin was determined (a = 15.404(1) Å, b = 15.281(1) Å, c = 17.890(1) Å, α = 99.662(1), β = 113.4230(1), γ = 102.481(1)°, P1; R1 = 6.71%) and allowed unambiguous determination of the absolute configuration of the stereogenic center of aegelinol. The pyranocoumarin guest is included within the cylindrical cavity formed by dimeric β-cyclodextrin molecules with a head-to-head arrangement. Crystal structure of aegelinol alone was also determined (a = 6.8921(3) Å, b = 11.4302(9) Å, c = 44.964(3) Å, P212121; R1 = 4.44%) and allowed precise determination of its geometry. Aegelinol crystallizes with three molecules in the asymmetric unit held together by H-bonds and π-stacking interactions.
We synthesized the new supramolecular host molecules 7 and 13 based on functionalized resorcarenes bearing Kemps triacid. Conformations in solution have been investigated and the influence of intra-and intermolecular hydrogen bonds from the triacid was shown by low temperature and DOSY NMR experiments. The results of host 7 are supported by DFT calculations. The binding behaviour of 7 towards different 2-amino pyridincs in chloroform has been investigated by NMR titrations. The association constants reach from K 207 M-1 for 2-amino-5-cyano pyridine to K=1551 M-1 for 2-amino-4-methyl pyridine. The association constants of the formed complexes of 7 with 2-amino pyridines were compared with those of the simple host systems 14 and 15 in order to evaluate the influence of the attached resorcarene host. (c) 2008 Elsevier Ltd. All rights reserved ...
Combining population genomic data with clinical information on the human IgG response to pneumococcal proteins provides a unique insight into the complex immunological interaction between host and pathogen. The continuous distribution of IgG binding values suggests that adaptive immunity responds to many antigens in both the core and the accessory genome. The most immunogenic proteins had physical properties expected to be associated with antibody binding: signal peptides, including those with a YSIRK motif, for secretion out of the bacterial cell; large size; and a lipoprotein processing motif, LPXTG sortase processing motif or CBD for surface attachment. The great majority of the ABTs either were variants of the diverse PspA, PspC, ZmpA, and ZmpB proteins or could be grouped into surface-exposed roles in host molecule adhesion or degradation, cell wall metabolism, or solute binding for transport. Despite the proteins on the microarray being expressed in vitro, detected ABTs included examples ...
INTRODUCTION. Structure-based drug design seeks to identify and optimize specific attractive interactions between two partner molecules in biological systems between ligands and their host molecules, typically proteins. The simple answer to whats holding the industry back in terms of adoption of latest drug discovery techniques is Education. There simply arent enough individuals trained on the use of Proteomics, Virtual Screening, Molecular Docking, Simulations, Dynamics and ADMET- multidisciplinary approaches, which is why we continue to offer courses, for both novice and experienced users, on the use of this technology as it applies to their research functions.. This 1 day training course will focus on the use of efficient technologies used in the discovery & designing of Drugs on the basis of the biological targets critical to the disease condition.. During this course, you will be introduced to basic principles of Rational Drug Design along with Proteomics in Drug Discovery. The course ...
These data show that there is an increasing potency of then-alkanol series for stabilizing BSA, but that the low aqueous solubility of the members longer than C10 limit the occupancy of n-alkanol binding sites, despite progressively increasing binding constants. For a soluble protein that does not significantly bind the alcohols studied, i.e., myoglobin, a progressive increase in potency for destabilization was observed until, again, a water solubility-limited cutoff effect occurred at about C10. Taken together, these results strongly suggest that solubility issues dominate then-alkanol cutoff effect. This is consistent with the observed shift in cutoff point in other homologous series. For example, relative to the C13-14 in vivo cutoff point for the saturatedn-alkanols, the less soluble n-alkane series have a shorter cutoff point (C10; Miller and Alifimoff, 1998), and the more soluble unsaturated n-alkanol series have a longer cutoff point (C15; Pringle et al., 1981). Also, similar in vivo ...
1OT1: The fully conserved Asp residue in Conserved sequence region I of the alpha-amylase Family is crucial for the Catalytic Site Architecture and Activity
The arrangement of the glucose units in the three different forms of cyclodextrin are shown in figure 26. The mouth of the torus-shaped cyclodextrin molecule has a larger circumference than at the base and is linked to secondary hydroxyl groups of the C2 and C3 atoms of each glucose unit (see figure 27). The primary hydroxyl groups are located at the base of the torus on the C6 atoms. As these hydroxyl groups are free to rotate, they partially block the base aperture. The size of the cavity increases with increasing number of glucose units (figure 26).The secondary hydroxyl groups can be reacted with appropriate reagents to introduce additional and different interactive character to the cyclodextrin molecule. The strong chiral selectivity of the cyclodextrins structures is thought to arise from the many chiral centers they contain (e.g., b-cyclodextrin has 35 stereogenic centers). The cyclodextrins are probably the most effective chirally selective stationary phases presently available for the ...
The solubility of natural cyclodextrins is very poor and initially this prevented cyclodextrins from becoming effective complexing agents. In the late 1960s, it was discovered that chemical substitutions at the 2-, 3-, and 6-hydroxyl sites would greatly increase solubility. The degree of chemical substitution and the nature of the groups used for substitution determine the final maximum concentration of cyclodextrin in an aqueous medium. Most chemically modified cyclodextrins are able to achieve a 50% (w/v) concentration in water.. Cavity size is the major determinant as to which cyclodextrin is used in complexation. "Fit" is critical to achieving good incorporation of cyclodextrins. α-Cyclodextrins have small cavities that are not capable of accepting many molecules. γ-Cyclodextrins have much larger cavities than many molecules to be incorporated, and cyclodextrin hydrophobic charges cannot effectively interact to facilitate complexation. The cavity diameter of β-cyclodextrins has been ...
article{7ad5f90a-94c1-4c5e-b086-8e73a88d96b6, abstract = {,p,Helicobacter pylori is an important human pathogen and a common cause of peptic ulcers and gastric cancer. Despite H. pylori provoking strong innate and adaptive immune responses, the bacterium is able to successfully establish long-term infections. Vitronectin (Vn), a component of both the extracellular matrix and plasma, is involved in many physiological processes, including regulation of the complement system. The aim of this study was to define a receptor in H. pylori that binds Vn and determine the significance of the interaction for virulence. Surprisingly, by using proteomics, we found that the hydrogen peroxide-neutralizing enzyme catalase KatA is a major Vn-binding protein. Deletion of the katA gene in three different strains resulted in impaired binding of Vn. Recombinant KatA was generated and shown to bind with high affinity to a region between heparin-binding domain 2 and 3 of Vn that differs from previously characterised ...
Have you wondered whether Febreze actually removes odors or whether it just covers them with a perfume? Have you wondered how it works? Heres the lowdown on Febreze. Its a product that was invented by Procter & Gamble and introduced in 1996. The active ingredient in Febreze is beta-cyclodextrin, a carbohydrate. Beta-cyclodextrin is an 8-sugar ringed molecule that is formed via an enzymatic conversion of starch. The cyclodextrin molecule sort of resembles a donut. When you spray Febreze, the water in the product partially dissolves the odor, allowing it to form a complex inside the hole of the cyclodextrin donut shape. The stink molecule is still there, but it cant bind to your odor receptors, so you cant smell it. Depending on the type of Febreze youre using, the odor might simply be deactivated or it might be replaced with something nice-smelling, like a fruity or floral fragrance. As Febreze dries, more and more of the odor molecules bind to the cyclodextrin, lowering the concentration ...
The synthesis and structural analysis of two novel families of three-component reversible redox cycles [(C2B9H11)M(m-SPh)2]2nPPNn (M = Mo, n = 2-, 2; 1-, 3; 0, 4; and M = W, n = 2-, 6; 1-, 7; 0, 8), where the cleavage and re-formation of the carborane cage C-C bond is observed during the redox reaction, are reported. Electronic saturation of the metal center (18e center) and the lack of bulky substituents on the carborane cage suggest that the deformed carborane cages in 2·PPN2, 6·PPN2, and 7·PPN invoke a new kind of deformed cage (semicloso framework). The XPS results show that the unprecedented competition for electron density between the metal center and the carborane cage is involved in the cleavage and formation of the carborane C-C bond. ...
To create an oil and water emulsion, it is necessary to put in a great deal of energy and to add an emulsifier to the mixture. Creating an unstable emulsion only requires stirring the mixture fast....
Polyelectrolyte multilayers assembled from hyaluronic acid (HA) and poly-l-lysine (PLL) are most widely studied showing excellent reservoir characteristics to host molecules of diverse nature; however, thick (HA/PLL)n films are often found cell repellent. By a systematic study of the adhesion and proliferation of various cells as a function of bilayer number "n" a correlation with the mechanical and chemical properties of films is developed. The following cell lines have been studied: mouse 3T3 and L929 fibroblasts, human foreskin primary fibroblasts VH-Fib, human embryonic kidney HEK-293, human bone cell line U-2-OS, Chinese hamster ovary CHO-K and mouse embryonic stem cells ...
1cdg: Nucleotide sequence and X-ray structure of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 in a maltose-dependent crystal form.
Branched cyclodextrins are produced by the pyrolysis of cyclodextrins. The temperature range is 135 C. to 220 C. using equipment suitable for making British gum and other starch dextrins.
Hi everyone.... Thanks to all of you who responded to my article request.......& heres another question Does anyone know of a staining method that would demonstrate the limit dextrin, after amylase digestion in FFPE tissue..... Thanks WAY in advance.... Good Weekend to all.... Luis _______________________________________________ Histonet mailing list [email protected] http://lists.utsouthwestern.edu/mailman/listinfo/histonet ...
Cyclodextrins - Roquette is a pioneer in the industrial development of Betacyclodextrins, bio-transformation of starch. | Roquette
Shop Beta-amylase ELISA Kit, Recombinant Protein and Beta-amylase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
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Formation of maltosyl cyclodextrins from mixtures of maltose and cyclodextrins by reverse reactions of Flavobacterium isoamylase and Klebsiella pullulanase was experimented and it was found that Klebsilla pullulanase produced 50.4 mg maltosyl alpha-cyclodextrin, 35.0 mg maltosyl beta-cyclodextrin and 55.4 mg maltosyl gamma-cyclodextrin per ml of reaction mixture, whereas Flavobacterium isoamylase did not form maltosyl cyclodextrins. Optimum conditions for formation of maltosyl beta-cyclodextrin by Klebsiella pullulanase were pH 4, 50 degrees C reaction temperature and proportion of substrate 100 mg beta-cyclodextrin/600 mg maltose per ml ...
Novelty, in brief, is represented by the intended elaboration of carborane, heteroborane and metallaborane compounds as active-site inhibitors of CA isoenzymes. All currently used inhibitors anhydrase inhibitors contain a sulfonamide or a sulfamate moiety connected to so called ring structure which is usually a 5- or 6-membered aromatic ring or conjugated ring system containing nitrogen, oxygen, and/or sulfur heteroatoms. The ring structure bears characteristics or functionality which modulates the affinity toward certain CA isoform. The use of three-dimensional boron cluster is a novel approach in development of isoform-specific CA inhibitors. Selected sulfamides incorporating cluster with inhibitory effects toward CAs (IC50 values in low micromolar and submicromolar range, some of the inhibitors being more than 50-times more selective toward the tumor specific CAIX than for CAII abundantly present in normal tissues ...
β-N-acetylhexosaminidase exhibits a relatively high activity in human epididymis. Its isoenzymatic profile and immunological properties led us to conclude that the increased activity was not due to the expression of an isoform unrelated to the HEX A and B present in other human tissues. Measurement of enzyme levels in the three distinct epididymal regions revealed that in any given sample, activity was higher in the caput than in the corpus or cauda. Moreover, we found a striking correlation between β-HEX activity in the caput region and concentrations of blood testosterone, suggesting a possible involvement of the hormone in modulating enzyme expression. Since the caput epididymis plays a role in the maturation of sperm cells, our data may be an indication that β-HEX activity in the caput has a physiological relevance in human epididymis functions.. ...
... A novel membrane was developed by growing polymer chains from the surface of a porous ceramic support, resulting in a composite membrane which combines the mechanical properties of the inorganic membrane with the selective interactions of the polymer. The configuration of the grafted polymer brush layer is determined by solvent - polymer interactions, with a hydrophilic polymer being stretched away from the surface by aqueous solutions and collapsed against the surface by organic solvents. This behavior of the grafted chains provides Ceramic-Supported Polymeric (CSP) membranes with unique properties for certain water treatment applications. One application envisioned for these CSP membranes, in which the selectivity is influenced by interactions between the solvent and the grafted polymer, is the cross-flow filtration of an oil-in-water emulsion. In this case, a hydrophilic grafted polyvinylpyrrolidone (PVP) brush layer
In the past years, cyclodextrins (CDs) became more and more an important excipient for drug formulations. The main use of CDs in ophthalmic drug delivery is to increase the water solubility of lipophilic drugs, to modify drug bioavailability and to reduce ocular irritation. In the present study, the corneal permeability of different betablockers (in part combined with pilocarpine) in the presence of alpha-CD and hydroxypropylated (HP) alpha-, beta- and gamma-CD was examined. Addition of CDs often led to significant changes in permeation parameters, compared to CD-free solutions. The prodrug mycophenolate mofetil and its active drug mycophenolic acid (MPA) were solubilized by HP-beta-CD. The intraocular availability of these solutions was studied in the rabbit eye in vivo in comparison to a MMF-suspension. Applying MMF/HP-beta-CD-solution, the MPA level in cornea and aqueous humour (after 60 min) turned out to be significant higher than those of the MMF-suspension. In addition, for the extremely ...
A new technique to produce very small magnetic nanoparticles of maghemite (gamma-Fe(2)O(3)) is presented. The particles form and precipitate in the presence of the oligosaccharide gamma-cyclodextrin and in the final product remain entrapped in tiny pseudo-single crystals of the organic host. Evidence of nanosized particles embedded in the organic crystal was obtained by HR-TEM studies that showed the occurrence of uniformly dispersed particles with average diameter of 18 Angstrom. The resulting objects gave diffraction patterns with the same spacing as that of cyclodextrin crystals without iron. The magnetic properties were investigated by ZFC-FC magnetizations, hysteresis loops, and ac susceptibility measurements. The compound presents a complex magnetic behavior that deviates from that predicted on the basis of the classic single domain particle model. The deviation is ascribed to the complex properties of the surface, which, for such small sizes, plays the major role in determining the total ...
TY - JOUR. T1 - Interactions between cyclodextrins and cell-membrane phospholipids. AU - Szejtli, J.. AU - Cserháti, T.. AU - Szögyi, M.. PY - 1986. Y1 - 1986. N2 - The interactions between cyclodextrins (CDs) and selected cell membrane phospholipids, liposomes and human erythrocytes were studied. Non-methylated cyclodextrins did not influence the differential scanning calorimetric behaviour of phospholipids and did not increase the permeability of dipalmitoyl-phosphatidyl-choline liposomes. Dimethyl- and trimethyl- β-CD interacted with the phospholipids but the effect was negligible compared to the effect of valinomycin. Reversed-phase thin-layer chromatography revealed complex formation with dimethyl-β-cyclodextrin, but not with others. The addition of cyclodextrins up to 10-2 mol litre-1 concentration did not modify the active or passive alkali ion transport of human erythrocytes, however, higher concentrations of added β-cyclodextrin especially dimethyl-β-cyclodextrin resulted in ...
As expected the addition of enzymes boosted attenuation. Beano seems to digest more dextins than a malt extract. I wonder to what extent the difference is caused by limit dextrins (1-6 glucose links), which can only be broken by limit dextrinase, an enzyme which likely did not survive the 30 min mash at 60 C. Beanos glucoamylase is likely able to cleave both the 1-4 and the 1-6 links found in starch leaving only glucose and no limit dextrins.. It was surprising, however, that even with enzyme use during fermentation the apparent attenuation stayed in the mid 80s. This suggests that the low wort fermentability may not have been the result of incomplete starch and dextrin break-down during the mash. After all, I was going for very fermentable wort and held 30 min rests at 55 C, 63 C and 65 C followed by a 45 min rest at 72 C. I was expecting to get an attenuation limit in the high 80s with this mash schedule.. There was also a drop in pH. I contribute this to the extended fermentation activity, ...
Carbohydrate is a major component of the human diet, and includes starch (amylose and amylopectin) and disaccharides such as sucrose, lactose, maltose and, in small amounts, trehalose. The digestion of starch begins with the action of amylase enzymes secreted in the saliva and small intestine, which convert it to maltotriose, maltose, limit dextrins, and some glucose. Digestion of the limit dextrins and disaccharides, both dietary and starch-derived, to monosaccharides - glucose, galactose, and fructose - is accomplished by enzymes located on the luminal surfaces of enterocytes lining the microvilli of the small intestine (Van Beers et al. 1995).. ...
A process for treating an emulsion or solution of water and oil or the like comprising the steps of (a) contacting said emulsion or solution with an inorganic salt; (b) contacting said emulsion or sol
A process for controlling sulfur-oxide formation and emissions when burning a combustible fuel prepared from a hydrocarbon containing sulfur comprising forming a hydrocarbon in water emulsion and adding to the hydrocarbon in water emulsion a water soluble additive selected from the group consisting of Na+, K+, Li+, Ca++, Ba++, Mg++, Fe+++ and mixtures thereof so as to obtain SO2 emission levels upon combustion of said emulsion of less than or equal to 1.50 LB/MMBTU.
The photochem. behavior of alkyldeoxybenzoins $PhCOCHPhCH_2CH_2R$ (R = H, Me, Et, hexyl, decyl) has been investigated in isotropic org. solvents, in aq. cyclodextrin solns., and bound to cyclodextrin in the solid state. Norrish type I and type II reactions occur in these media and the product distribution resulting from these primary processes are dependent on the medium. In org. solvents, type I and type II products are obtained in equal amts. In aq. cyclodextrin soln., type II products are formed in large excess. In the solid state, type II products constitute more than 90% of the product distribution. Ratios of products resulting from elimination and cyclization from the type II 1,4-diradical are also altered by the host cyclodextrin. Conformational and super-cage effects have been invoked to rationalize the dramatic alteration of the photobehavior of alkyldeoxybenzoins by cyclodextrin.. ...
Different from EC 3.2.1.142 (limit dextrinase) in its action on glycogen, and its rate of hydrolysis of limit dextrins. Its action on amylopectin is complete. Maltose is
The other activity is similar to that of EC 2.4.1.25, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyze ...
TY - GEN. T1 - Branching of cyclodextrins with various mono-, di-, and tri-saccharides by Bacillus acidophilus pullulanase.. AU - Madsen, U.. AU - Larsen, Kim Lambertsen. PY - 2002. Y1 - 2002. KW - Bioteknologi. KW - Bioteknologi. M3 - Article in proceeding. BT - Third Nordic Starch network Symposium. PB - Denmark.. ER - ...
The step-by-step analysis of high-resolution proton and 13C NMR spectra of per-O-methylated-6-monoamino and 6,6-diamino-A,D-β-cyclodextrins is described. Selected 2-D experiments (COSY, NOESY, HSQC, DEPT, and HMBC) allowed us to challenge the current interpretation. The full assignment of the proton and carbon-13 NMR spectra of these two compounds was performed enabling us to complete the assignment of NMR spectra acquired at 500 and 800 MHz for these important synthetic intermediates ...
Trans-2-hexenal, a naturally occurring plant volatile with antimicrobial capacity, was encapsulated into β-cyclodextrins (β-CDs), enzymatically modified starch, and shown effective to control main microorganisms causing food spoilage (Alternaria so
The three-dimensional structures of the catalytic residue Glu219--|Gln mutant of Pseudomonas stutzeri maltotetraose-forming exo-alpha-amylase, and its complex with carbohydrate obtained by cocrystallization with maltopentaose were determined. Two cry
The perspective of adding stimuli-response to isoporous membranes stimulates the development of separation devices with pores, which would open or close under control of environment chemical composition, temperature or exposure to light. Changes in pH and temperature have been previously investigated. In this work,
A major factor in the survival of an organism is its ability to communicate with and respond to its environment. Among the environmental factors is a portion of the electromagnetic spectrum, from...
The preparation and characterization of a supramolecular host-guest inclusion complex between a fluorescent indolizinyl-pyridinium salt and β-cyclodextrin is reported. The formation of the inclusion complex was investigated by ESI-MS experiments, transmission electron microscopy, Jobs plot investigations an
Non-covalent bonds between aromatic rings and a hydrogen joined to either a carbon, nitrogen or oxygen atom, are common and critical in molecular biology. These relatively weak electrostatic bonds are the currency of countless biomolecular interactions between proteins, nucleic acids and the milieu of molecules on which life relies. Theoreticians and experimentalists have looked closely at many of these bonds and modelled the likes of benzene-haloalkane, benzene-ammonia and benzene-water complexes. Such bonds in, for example, carborane systems have hinted at a new approach to drug design in which a B-H group interacts with a proton donor in a target biomolecule. However, an interaction between a B-H and an aromatic ring had not been observed until now ...
Zhiyuan Biological is one of the leading China cyclodextrin complexes manufacturers and suppliers, as a professional company, we have productive factory, which is able to produce high-quality cyclodextrin complexes at good price. Welcome to buy products from us.
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Publication Details (including relevant citation information): Nociari, M.M., Lehmann, G.L., Perez Bay, A.E., Radu, R.A., Jiang, Z., Goicochea,
yes, its written by patrick arnold and yes its an ad for ergopharms product....but you know what? they have never deceived us (knowingly) and
For my own experiments I was curious how exactly you go about complexing a compound with cyclodextrins(CD), primarily a hydrophobic compound. Ive
Page contains details about sugar appended β-cyclodextrin derivative-capped metallo-glycodendrimers . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
[102 Pages Report] Check for Discount on Global Dextrin Sales Market Report 2017 report by QYResearch Group. In this report, the global Dextrin market is valued at...
In vitro studies of α-amylase degradation of α-, β- and γ-cyclodextrins and 2-hydroxypropyl-β- and -γ-cyclodextrins were investigated spectrophotometrically by measuring the formation of reducing sugars, the reaction products of α-amylase degradation. This was done to evaluate potential degradation and thereby biological conversion of the cyclodextrins if dosed orally, as the intestinal tract contains α-amylase for digestive purposes. The results demonstrated that only γ- and 2-hydroxypropyl-γ-cyclodextrins can be degraded by α-amylase to a relevant extent, that is, γ- and 2-hydroxypropyl-γ-cyclodextrins have different biopharmaceutical behaviours than the other evaluated cyclodextrins. The rate of degradation was affected by the addition of the inclusion complex forming additives flurbiprofen, ibuprofen and benzo[a]pyrene. This effect between the degradation dynamics and the included additives was caused by a correlation between solubility of the additives and the stability of the ...
1. To determine whether activation of the left ventricular C-fibre mechanoreceptors initiates the vasodepressor reflex that often causes syncope, we exposed six orthotopic cardiac transplant patients and six matched, healthy control subjects to progressively increasing lower body negative pressure until the onset of vasodepressor responses.. 2. There was no significant difference (P = 0.78) between the central hypovolemia tolerances of the cardiac transplant and the control groups.. 3. The decrease in systolic blood pressure before the onset of vasodepressor reflexes was greater in the cardiac transplant group. The cardiac transplant group did not maintain diastolic blood pressure during central hypovolaemia. From baseline to the onset of vasodepression, there were no differences in leg circumference, forearm blood flow and forearm vascular resistance responses between the two groups.. 4. We conclude that the left ventricular mechanoreceptors may not be the primary afferent trigger for ...
A suitable host-guest inclusion complex has beenmade with a guest molecule, 1-methyl-3- octylimidazolium chloride ([MOIm]Cl) and a host molecule, α-cyclodextrin in aqueous medium. Formation of the host-guest inclusion complex has been established by Surface tension and conductivity readings while1H NMR and ultraviolet spectroscopy readingconfirms1:1 host-guest stoichiometry. These results have implications for the formation of host-guest inclusion complex of studied ionic liquid as guest in aqueous α-cyclodextrin media.. ...
Molecular recognition and self-assembly in aqueous solution have experienced rapid growth in recent years. The use of alpha-, beta-, and gamma-cyclodextrins, calixarenes, and cyclophanes have served as the platforms for molecular recognition in aqueous solution. Recently, the investigation of an alternative platform based on cucurbituril has become the focus of several research groups. The rigid structure and capability of forming complexes with molecules and ions through hydrophobic, ion-dipole and hydrogen-bonding interactions make cucurbituril an attractive candidate as a synthetic receptor as well as a building block for the construction of supramolecular architectures. However, before cucurbituril can be used to supplant the more common platforms as the molecule of choice for molecular recognition and self-assembly in aqueous solution, several advances must be made: 1) cucurbiturils must become available in a variety of sizes, 2) their solubility must be improved, and 3) synthetic ...
Molecular tweezers, and molecular clips, are noncyclic host molecules with open cavities capable of binding guest molecules. The term "molecular tweezers" was first used by Howard J. Whitlock, but the class of hosts was developed and popularized by Steven C. Zimmerman in the mid-1980s to early 1990s and later by Frank-Gerrit Klärner and colleagues. The open cavity of the molecular tweezers may bind guests using non-covalent bonding which includes hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, π-π interactions, and/or electrostatic effects. These complexes are a subset of macrocyclic molecular receptors and their structure is that the two "arms" that bind the guest molecule between them are only connected at one end leading to a certain flexibility of these receptor molecules (induced fit model). One example of molecular tweezers has been reported by Lehn and coworkers. This molecule is capable of binding aromatic guests. The molecular tweezers are composed of ...
Bifidobacterium is an important genus of the human gastrointestinal microbiota, affecting several host physiological features. Despite the numerous Bifidobacterium related health-promoting activities, there is still a dearth of information about the molecular mechanisms at the basis of the interaction between this microorganism and the host. Bacterial surface associated proteins may play an important role in this interaction because of their ability to intervene with host molecules, as recently reported for the host protein plasminogen. Plasminogen is the zymogen of the trypsin-like serine protease plasmin, an enzyme with a broad substrate specificity. Aim of this thesis is to deepen the knowledge about the interaction between Bifidobacterium and the human plasminogen system and its role in the Bifidobacterium-host interaction process. As a bifidobacterial model, B. animalis subsp. lactis BI07 has been used because of its large usage in dairy and pharmaceutical preparations. We started from the ...
in Journal of Pharmaceutical & Biomedical Analysis (2007), 43(3), 910-919. The inclusion complexes of tagitinin C with beta-, 2,6-di-O-methyl-beta- and gamma-cyclodextrin (CyD) was investigated in aqueous medium. The stoichiometric ratios and stability constants (K(f)) which ... [more ▼]. The inclusion complexes of tagitinin C with beta-, 2,6-di-O-methyl-beta- and gamma-cyclodextrin (CyD) was investigated in aqueous medium. The stoichiometric ratios and stability constants (K(f)) which describe the extent of formation of the complexes have been determined by UV spectroscopy and direct current tast polarography (DC(tast)), respectively. For each complex, a 1:1 molar ratio was formed in solution and the trend of stability constants was K(f) (2,6-di-O-methyl-beta-CyD),K(f) (gamma-CyD),K(f) (beta-CyD). The effect of molecular encapsulation on the photochemical conversion of tagitinin C was evaluated. No significant protection efficacy was noticed with beta- and gamma-CyD for the complexed drug ...
In 2005, he started to work on his PhD thesis in the group of Prof. Qijin Zhang at the University of Science and Technology of China. In 2007, he was supported by the joint doctoral promotion program of the Max Planck Society and the Chinese Academy of Sciences to work with Prof. Christoph Bubeck at the Max Planck Institute for Polymer Research, Mainz, Germany. In 2010, he received his PhD on photoresponsive composites of azopolymers. From 2010 to 2012, he worked as a postdoc at the Max Planck Institute for Polymer Research. He has been a group leader at the Max Planck Institute for Polymer Research since 2012. He is now heading an experimental group focusing on photoresponsive materials, including photoresponsive polymers and photoresponsive nanomaterials.. ...
Conversion of Carbon Dioxide to Few‑Layer Graphene. Chakrabarti, A.; Lu, J.; Skrabutenas, J.C.; Xu, T.; Xiao, Z.; Maguire, J.A.; Hosmane, N.S.(2011) J. Mater. Chem., 21: 9491-9493.. Nano and Dendritic Structured Carboranes and Metallacarboranes: From Materials to Cancer Therapy. Hosmane, N. S.; Yinghuai, Z.; Maguire, J. A.; Kaim, W.; Takagaki, M. (2009) J. Organomet. Chem., 694: 1690-1697.. Synthesis, Characterization and Polymerization of a Neutral Tantalacarborane Sandwich Complex Derived from Quintanionic exo‑Polyhedrally Linked Bis(C2B10‑carborane) Ligands. Yinghuai, Z.; Nong, L. C.; Zhao, L. C.; Widjaja, E.; Hwei, C. S.; Cun, W.; Tan, J.; Van Meurs, M.; Hosmane, N. S.; Maguire, J. A. (2009) Organometallics, 28: 60-64.. Silicon (IV) and Germanium (IV) Moieties Stabilized by Charge‑Compensated Carborane Ligand, [9‑SMe2‑7,8‑C2B9H10]−: Synthetic and Structural Investigation. Vladimir Meshcheryakov, V.; Zheng, C.; Kudinov, A. R.; Maguire, J. A.; Hosmane, N. S.(2008) ...
A luminescence detection device for quantitatively detecting an analyte in a liquid sample, which device comprises (1) a reaction compartment having, along a primary axis, opposite end portions, a first of which is for introduction of fluid reagents and sample into the compartment and the other of which forms a light transmissive aperture of predetermined size, the compartment being suitable to hold a composition which luminesces in response to contact with analyte-containing sample; (2) closure means in said first end portion for admitting a cannula, whereby fluid is introduced into said compartment, and for closing the reaction compartment; (3) a photoresponsive imaging layer; (4) means for associating the photoresponsive imaging layer and the reaction compartment such that the photoresponsive imaging layer is positioned preferably substantially perpendicular to the primary axis of the reaction compartment, at a predetermined distance from the end portion forming the aperture so as to be exposed
This enzyme, like EC 3.2.1.33 (amylo-alpha-1,6-glucosidase), can release an alpha-1->6-linked glucose, whereas the shortest chain that can be released by EC 3.2.1.41 (pullulanase), EC 3.2.1.142 (limit dextrinase), and EC 3.2.1.68 (isoamylase) is maltose. It also hydrolyses isomaltulose (palatinose), isomaltotriose and panose, but has no action on glycogen or phosphorylase limit dextrin. The enzyme from intestinal mucosa is a single polypeptide chain that also catalyses the reaction of EC 3.2.1.48 (sucrose alpha-glucosidase). Differs from EC 3.2.1.33 (amylo-alpha-1,6-glucosidase) in its preference for short-chain substrates and in its not requiring the 6-glucosylated residue to be at a branch point, i.e. linked at both C-1 and C-4 ...
Principal Investigator:YUI Nobuhiko, Project Period (FY):1997 - 2000, Research Category:Grant-in-Aid for Scientific Research (B)., Section:一般, Research Field:Biomedical engineering/Biological material science
Cyclodextrins: Roquette offers a wide range of betacyclodextrins KLEPTOSE® with different characteristics, solubility, water content, compactibility. | Roquette
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where [P]0 denotes the initial concentration of IBU and [CD]0 denotes that of CDs. F and F0 are the fluorescence intensities of IBU in the presence and absence of CDs, respectively. K is a formation constant, k is the instrument constant and Q is the fluorescence quantum yield of the inclusion complex. If the curve of 1/(F-F0) versus 1/[CD]0 exhibits good linearity, it implies that inclusion complexes with a stoichiometry of 1:1 are formed. B. Effect of the types of CDs β-CDs have the hydrophilic outer surface and a hydrophobic internal cavity. The inclusion interaction of β-CDs and the guest molecules is affected by the size of the internal cavity and hydrophilic, hydrophobic characters of the host. It is generally believed that dipole-dipole, electrostatic, van der Walls forces, hydrogen bonding, hydrophobic interaction, and the release of distortion energy of CD ring upon guest binding cooperatively govern the stability of an inclusion complex. The effect of HP-β-CD concentration on the ...
Energetic compositions and the process for obtaining same for use as the ignitable composition in infrared emitting decoy flares, for high temperature ignition compositions, and the like, are disclosed. These compositions are attained by combining a fluorinated hydrocarbon, either in a liquid state or as a water emulsion, with a powdered metal fuel such as aluminum, magnesium, titanium or zirconium to yield volatile solvent free energetic compositions.*FUELS
Page contains details about octadecyl acrylate-modified polyamidoamine dendrimer G5 . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
We have recently described a novel cyclic tetrasaccharide of D-glucose (Cote & Biely, Eur. J. Biochem. 226:641-648, 1994), and would like to know if anyone in the carbohydrate chemistry community has any ideas for using it. We would especially like to collaborate with someone who would like to study its ability to complex small molecules or ions. It has practically no internal cavity, so would probably not form inclusion complexes similar to those of cyclodextrins. We can only provide milligram amounts at this time, and only if your idea is interesting and has scientific merit. Please contact me via e-mail or snail mail. Gregory Cote USDA/ARS/NCAUR 1815 N. University St. Peoria, IL 61604 E-mail: cotegl at ncaur1.ncaur.gov ...
ß-Cyclodextrin, base (BCD) for biochemistry & microbiology datasheet and description hight quality product and Backed by our Guarantee
I wonder if we need a place for XMRV specific treatments in the treatment secion. Cyclodextrin is currently being used to treat the twins with...
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Boc Sciences is the worlds leading provider for special chemicals. We offer qualified products for 104723-60-6(6-o-alpha-Maltosyl-beta-cyclodextrin),please inquire us for 104723-60-6(6-o-alpha-Maltosyl-beta-cyclodextrin).
Separation of dicarboxylic acids by means of a host-guest interaction is challenging because the mixtures include isomers or molecules that are very geometrically similar. This is the case for two important dicarboxylic acids, fumaric acid and maleic acid. Fumaric acid is an intermediate product in the energy metabolism of all cells. It has many applications in the food and pharmaceutical industries. Maleic acid is used in polymer production, dying cotton, and decalcifying agents.. Fumaric acid is usually obtained through the isomerization of maleic acid, which is harmful to health, so all residues of maleic acid must be scrupulously removed from the fumaric acid product. As the host molecule for their separation, the research team selected a polyamine that consists of two oxygen-containing, six-membered, hydrocarbon rings bound together through a hydrocarbon chain that contains three amino groups. This compound is flexible and can crystallize in different conformations. This host molecule ...
The structure of 2,3,7,8-tetramethyl-2,3,7,8-tetracarbadodecaborane(12) [(CH3)4C4B8H8], a carborane formed by air oxidation of [(CH3)2C2B4H4] 2CoH or [(CH3)2C2B4H4] 2FeH2, has been determined from a single-crystal x-ray diffraction study. The molecule is a distorted icosahedron, in which two carbon-carbon bonds have been severed to create two four-sided open faces, and consists of two pyramidal (CH3)2C2B4H4 units fused face-to-face with the four skeletal carbon atoms forming a contiguous chain. The polyhedral cage contains two more electrons than the icosahedral C2B10H12 system and is isoelectronic with the C2B10H12 2- ion. The geometry of (CH3)4C4B8H8 differs sharply from those of the only other structurally established 12-vertex nido systems, (C6H5)2C2B10H 11 - and (η5-C5H5)Fe(CH3) 4C4B7H8, each of which has a single large open face. The compound crystallizes in the monoclinic space group P21/n with a = 8.398 (3) Å, b = 11.420 (5) Å, c = 13.458 (7) Å, β = 90.61 (4)°, dobsd = 1.05 g cm-3, and
The outer membrane (OM) is the front line of leptospiral interactions with their environment and the mammalian host. Unlike most invasive spirochetes, pathogenic leptospires must be able to survive in both free-living and host-adapted states. As organisms move from one set of environmental conditions to another, the OM must cope with a series of conflicting challenges. For example, the OM must be porous enough to allow nutrient uptake, yet robust enough to defend the cell against noxious substances. In the host, the OM presents a surface decorated with adhesins and receptors for attaching to, and acquiring, desirable host molecules such as the complement regulator, Factor H. On the other hand, the OM must enable leptospires to evade detection by the hosts immune system on their way from sites of invasion through the bloodstream to the protected niche of the proximal tubule. The picture that is emerging of the leptospiral OM is that, while it shares many of the characteristics of the OMs of ...
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rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" , ,rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/13594", ,dc:contributor,Fillaut, Jean-Luc,/dc:contributor, ,dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime",2011-06-17T07:17:23Z,/dcterms:available, ,bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13594"/, ,dc:contributor,Kutta, Roger-Jan,/dc:contributor, ,dcterms:abstract xml:lang="eng",Novel photoresponsive materials based on ruthenium(II) σ-acetylides coupled to an azobenzene moiety in the main π-conjugated chain have been synthesized. The introduction of a metal acetylide ...
Books by International Symposium on Cyclodextrins (8th 1996 Budapest, Hungary), Proceedings of the Eighth International Symposium on Cyclodextrins, Budapest, Hungary, March 31-April 2, 1996
Equilibrium constants and standard enthalpies have been measured calorimetrically for the formation of complexes of α-and β-cyclodextrins with substituted phenols in aqueous solutions at 298.15 K. The study includes variation of the size and shape of the phenol, the size and degree of methylation of the cyclodextrin, and the effects of pH and ionic strength. Substituent effects were measured for p-chloro-, p-bromo-, p-methyl-, p-hydroxy-, p-nitro- and m-nitrophenols. The effects of ionization were studied with m- and p-nitrophenolate ions. The effects of methyl substitutions of β-cyclodextrin were investigated with nitrophenol and nitrophenolate ions complexing with heptakis(2,6-di-O-methyl)-β-cyclodextrin and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin. All of the effects studied show a substantial amount of entropic-enthalpic compensation, such that free energy effects are relatively small in comparison to enthalpic and/or entropie effects, but there was no simple relationship between the
Inclusion complexes of cyclodextrins, particularly β-cyclodextrin, and cardiac glycosides, particularly digoxin, are disclosed. The complexes have high aqueous solubility and are useful in the preparation of pharmaceutical formulations containing cardiac glycosides for use in therapy.
The inclusion complexation of pyrimethamine in 2-hydroxypropyl-beta-cyclodextrin has been investigated by 2D H-1 NMR, FTIR and UV/visible spectroscopy and also by molecular modelling methods (AM1, PM3, MM3). From the phase-solubility diagram a linear increase was observed in pyrimethamine aqueous solubility in the presence of 2-hydroxypropyl-beta-cyclodextrin, evidencing the formation of a soluble inclusion complex. According to the continuous variation method (Jobs plot) applied to fluorescence measurements, a 1:1 stoichiometry has been proposed for the complex. Concerning the structure of the complex, a Cl-in orientation of pyrimethamine in the 2-hydroxypropyl-o-cyclodextrin cavity has been proposed from the theoretical calculations, being confirmed by two-dimensional H-1 NMR spectroscopy (ROESY). The thermal behaviour has also been studied, providing complementary evidences of complex formation. (c) 2007 Elsevier Ltd. All rights reserved ...
From the kinetic investigation of the cleavage of the 4-acetoxybenzoate anion (4-ABA) in the presence of three cyclodextrins (Ì-CD, Ý-CD, and Þ-CD) in basic aqueous solution, the results indicate that 4-ABA binds to Ì-CD fairly weakly while no binding is observed between 4-ABA and Ý-CD or Þ-CD. The effects of the three CDs on the kinetics of the aminolysis of 4-ABA by primary amines have been investigated. Rate constants for the nucleophilic attack by free and CD-bound amine are obtained. For Ì-CD, values of the reactivity ratios for the linear amines are low (,1) implying deceleration of the aminolysis reaction due to binding to the CD. In the case of Ý-CD, the reactivity ratios are slightly larger (,1 for both n -alkyl and branched amines), implying modest catalysis. As for Þ-CD, the values of the reactivity ratios are ,2, which also signifies modest catalysis ...
Figure 6: DSC thermograms of a β-CD : Cin system. From top: Cin : β-CD inclusion complex, pure β-CD, and physical mixture of Cin and pure β-CD ...
Genistein: β-cyclodextrin complexes with high drug loading (19.22%) were prepared by freeze-drying and characterized by differential scanning calorimetry and hydrogen nuclear magnetic resonance spectroscopy. The spatial configuration of the complex was proposed by means of 2D-NOESY experiment combined with molecular modeling. According to the results obtained, the interaction of genistein with β-cyclodextrin in a 1:1 complex is supposed to occur mainly through the insertion of the guest A-ring in cyclodextrin cavity, without rule out the possibility of inclusion through the B-ring, as previously reported in the literature ...
Vijaya Enterprises dealing in Corn Dextrins, Dextrin Powder, Exporters of Corn Dextrin, Corn Dextrin Products, Corn Dextrins Suppliers from India.
Abstract Hydrogels are soft materials composed of a three-dimensional network which contain a high percentage of water similar to body tissue and are therefore regarded as a biocom..
The present invention relates to a process for producing a creamer comprising; (a) i) incorporating a mineral into an oil component by high shear mixing to provide a first composition; and ii) mixing the first composition with an aqueous component to provide a second composition; or (b) i) incorporating a mineral into an aqueous component to provide a first composition; and ii) mixing the first composition with an oil component to provide a second composition; iii) homogenizing the second composition from step ii) of (a) or (b) to provide an oil-in- water emulsion.
I . Deprotonation of arachno -C 2 B 7 H 3 with KH to give K + arachno -C 2 B 7 H 12 - was studied and two reaction mechanisms were proposed. One mechanism involved a direction abstraction of possibly the most acidic hydrogen in the carborane by the strong base. The second mechanism involves an initial incorporation of a hydride ion from the metal hydride to form C 2 B 7 H 14 - . This intermediate which was not isolated would then lose H 2 gas to give aracho -4,5-C 2 B 7 H 12 - . Calculated chemical shifts of several isomers of C 2 B 7 H 12 - and C 2 B 7 H 14 - were not consistent with variant-temperature 1 H, 2 D, 11 B, 13 C NMR spectra of the reaction mixture. II . The rearrangement process of nido -4,5-C 2 B 6 H 10 was studied by studied by computational and low temperature NMR experiments. Nido -4,5-C 2 B 6 H 9 D was prepared and monitored by 2 D and 11 B NMR experiments to calculate a rate constant and an activation energy for the process. A calculated E a of ∼8 kcal/mol from the NMR ...
Germain, P. ; Lenders, JP. ; Guzman, LH. ; Crichton, Robert. The Immobilization of a Chemically Thermostabilized Beta-amylase.In: Archives Internationales de Physiologie et de Biochimie, Vol. 93, no. 3, p. B87-B87 (1985 ...
Cyclodextrin glycosyltransferase (CGTase) catalyzes the conversion of starch into non-reducing cyclic sugars, cyclodextrins, which have several industrial applications. This study aimed to establish optimal culture conditions for β-CGTase production by Bacillus sp. SM-02, isolated from soil of cassava industries waste water lake. The optimization was performed by Central Composite Design (CCD) 2, using cassava flour and corn steep liquor as substrates. The maximum production of 1087.9 U mL−1 was obtained with 25.0 g L−1 of cassava flour and 3.5 g L−1 of corn steep after 72 h by submerged fermentation. The enzyme showed optimum activity at pH 5.0 and temperature 55 °C, and maintained thermal stability at 55 °C for 3 h. The enzymatic activity was stimulated in the presence of Mg+2, Ca+2, EDTA, K+, Ba+2 and Na+ and inhibited in the presence of Hg+2, Cu+2, Fe+2 and Zn+2. The results showed that Bacillus sp. SM-02 have good potential for β-CGTase production.
Looking for online definition of 2-hydroxypropyl-beta-cyclodextrin or what 2-hydroxypropyl-beta-cyclodextrin stands for? 2-hydroxypropyl-beta-cyclodextrin is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
Author Summary Human African trypanosomiasis (HAT) is caused by infection with either Trypanosoma brucei gambiense or T.b.rhodesiense and is fatal if untreated. In the late stages of the disease the parasites enter the brain, producing severe neurological symptoms. The arsenical drug melarsoprol is the only treatment available for rhodesiense disease once it has reached the brain. Melarsoprol is very poorly soluble in water which severely limits its oral bioavailability. Currently melarsoprol is solubilised in propylene glycol which restricts its administration to the intravenous route and treatment schedules are protracted and extremely painful. Further, this formulation of melarsoprol is toxic and kills 5% of all treated patients through the induction of a severe post-treatment reactive encephalopathy. In this study we show that combining melarsoprol with cyclodextrin molecules increases the oral bioavailability of the drug. In a murine model of late stage HAT oral treatment regimens employing
Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of enantiomers. In this mode, one or more chiral selectors are added to the background electrolyte acting as pseudostationary phases. Within the various chiral selectors that have been applied to enantioseparations in capillary electrokinetic chromatography, cyclodextrins are by far the most often used selectors because of their versatility, structural variety and commercial availability. This is reflected in the large number of applications of cyclodextrins to analytical enantioseparations that have been reported between January 2012 and July 2016, the period of time covered by this review. Many of these applications cover aspects of life sciences such as drug analysis, bioanalysis or food analysis. Despite the large number of commercially available cyclodextrins, new derivatives have been developed in order to achieve altered enantioselectivities or ...
TY - JOUR. T1 - Glucosylation of sucrose laurate with cyclodextrin glucanotransferase. AU - Okada, Katsuhide. AU - Zhao, Haisuo. AU - Izumi, Minoru. AU - Nakajima, Shuhei. AU - Baba, Naomichi. PY - 2007. Y1 - 2007. N2 - Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester.. AB - Sucrose monolauroyl esters were found to serve as substrates for cyclodextrin glucanotransferase (CGTase)-catalyzed transglucosidation reactions, affording new sucrose esters that have an additional 1-3 glucose residues on the pyranose ring of the sucrose moiety in the ester.. KW - CGTase. KW - Cyclodextrin glucanotransferase. KW - Sucrose monolaurate. KW - Surfactant. UR - http://www.scopus.com/inward/record.url?scp=33947580881&partnerID=8YFLogxK. UR - ...

Alpha-Cyclodextrin - WikipediaAlpha-Cyclodextrin - Wikipedia

alpha-Cyclodextrin (α-dextrin, α-cyclodextrin, α-CD, alphadextrin, alpha cyclodextrin (dietary fiber)) is a polysaccharide of ... Tests showed that alpha cyclodextrins can cause a volume effect in various different food compositions with or without fat and ... Unlike lipase inhibitors, alpha-cyclodextrin forms a stable complex with the dietary fat which prevents lipase from digesting ... This fiber is sold under the brand names, "Alpha-Fibe" and "Calorease". Alpha-Fibe is the original product that contains this ...
more infohttps://en.wikipedia.org/wiki/Alpha-Cyclodextrin

RCSB PDB 









- 1G1Y: CRYSTAL STRUCTURE OF ALPHA-AMYLASE II (TVAII) FROM THERMOACTINOMYCES VULGARIS R-47 AND BETA...RCSB PDB - 1G1Y: CRYSTAL STRUCTURE OF ALPHA-AMYLASE II (TVAII) FROM THERMOACTINOMYCES VULGARIS R-47 AND BETA...

X-ray structure of the mutant E354A complexed with beta-cyclodextrin, and kinetic analyses on cyclodextrins. ... Studies on the hydrolyzing mechanism for cyclodextrins of Thermoactinomyces vulgaris R-47 alpha-amylase 2 (TVAII). ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases A4. 1g1yA04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ... Alpha Beta Alpha-Beta Barrel TIM Barrel Glycosidases B4. 1g1yB04. Mainly Beta Sandwich Immunoglobulin-like Golgi alpha- ...
more infohttp://www.rcsb.org/pdb/explore/derivedData.do?structureId=1G1Y

Patent US6878695 - Compositions comprising cyclodextrin derivatives - Google PatentsPatent US6878695 - Compositions comprising cyclodextrin derivatives - Google Patents

The compositions can further comprise cyclodextrin-compatible and -incompatible materials, and other optional ingredients. ... A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin ... alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, or mixtures thereof. The alpha-cyclodextrin consists of six glucose ... and/or beta-cyclodextrin and its derivatives thereof; more preferably a mixture of alpha-cyclodextrin, or an alpha-cyclodextrin ...
more infohttp://www.google.com.au/patents/US6878695

Repositorio da Producao Cientifica e Intelectual da Unicamp: Production of branched cyclodextrins by reverse reaction of...Repositorio da Producao Cientifica e Intelectual da Unicamp: Production of branched cyclodextrins by reverse reaction of...

... pullulanase was experimented and it was found that Klebsilla pullulanase produced 50.4 mg maltosyl alpha-cyclodextrin, 35.0 mg ... Formation of maltosyl cyclodextrins from mixtures of maltose and cyclodextrins by reverse reactions of Flavobacterium ... Production of branched cyclodextrins by reverse reaction of microbial debranching enzymes. Author: Yim, DK. Park, YH. Park, YH ... Optimum conditions for formation of maltosyl beta-cyclodextrin by Klebsiella pullulanase were pH 4, 50 degrees C reaction ...
more infohttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70398

Feasibility Studies: Alpha-Cyclodextrin Manufacturing - EnglishFeasibility Studies: Alpha-Cyclodextrin Manufacturing - English

Techno-economic analyses of specific alpha cyclodextrin production processes, presenting capital investment breakdown, raw ... ECONOMICS OF ALPHA-CYCLODEXTRIN PRODUCTION FROM CORN (ALPHA-CYCLODEXTRIN E12A) It presents the economics of alpha-Cyclodextrin ... Understand Alpha- Cyclodextrin production costs Industrial Process Economics About Alpha-Cyclodextrin Reports Coverage of Alpha ... ALPHA-CYCLODEXTRIN E11A) This report presents the economics of alpha-Cyclodextrin production from corn in the USA, using a ...
more infohttps://www.slideshare.net/intratec/feasibility-studies-alphacyclodextrin-manufacturing

RCSB PDB 









- 3L2M: X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Alpha-cyclodextrin Structure...RCSB PDB - 3L2M: X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Alpha-cyclodextrin Structure...

X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin. ... X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Alpha-cyclodextrin. *DOI: 10.2210/pdb3l2m/pdb ... Pancreatic alpha-amylase A 496 Sus scrofa EC#: 3.2.1.1 IUBMB Fragment: residues 16-511 Mutation: Q1X, A411D Gene Name(s): AMY2 ... ALPHA-D-GLUCOSE. C6 H12 O6 WQZGKKKJIJFFOK-DVKNGEFBSA-N ...
more infohttp://www.rcsb.org/pdb/explore.do?structureId=3l2m

Cyclodextrin glucanotransferase (CGTase) catalyzed synthesis of dodecyl glucooligosides by transglycosylation using alpha...Cyclodextrin glucanotransferase (CGTase) catalyzed synthesis of dodecyl glucooligosides by transglycosylation using alpha...

Cyclodextrin glucanotransferase (CGTase) catalyzed synthesis of dodecyl glucooligosides by transglycosylation using alpha- ... surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin ... surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin ... surfactant molecules were synthesized by cyclodextrin glucanotransferase from Bacillus macerans using either alpha-cyclodextrin ...
more infohttps://lup.lub.lu.se/search/publication/2278898

Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an <i>in vivo</i>...Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an <i>in vivo</i>...

Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation ... Cyclodextrins (CyDs) are cyclic oligosaccharides consisting of six to eight glucose residues. Administration of α-CyD (six ...
more infohttps://www.jstage.jst.go.jp/article/ddt/12/3/12_2018.01028/_article/-char/en

alpha cyclodextrin gold extractionalpha cyclodextrin gold extraction

... _BioResources: Peer-reviewed online journal for lignocellulosic science Hubbe, M. A., and ... alpha cyclodextrin gold extraction. 06/Apr/2010. polysorbate 20 9005-64-5 - The Good Scents Company Food Additive: Functional ... Cyclodextrin - Wikipedia, the free encyclopedia Cyclodextrins are able to form host-guest complexes with hydrophobic molecules ... beta-cyclodextrin 7585-39-9 - The Good Scents Company Category: carrier solvents, encapsulating agent for food additives, ...
more infohttp://www.santagusti.net/alpha-cyclodextrin-gold-extraction/

Molecular Weight of Alpha Cyclodextrin China ManufacturerMolecular Weight of Alpha Cyclodextrin China Manufacturer

Leading Molecular Weight of Alpha Cyclodextrin Manufacturers & Suppliers, find Molecular Weight of Alpha Cyclodextrin Factory ... China Molecular Weight of Alpha Cyclodextrin with High-Quality, ... Molecular Weight of Alpha Cyclodextrin * Alpha Cyclodextrin ... Home > Products > Natural Alpha Beta Gamma Cyclodextrin > Natural Alpha Cyclodextrin > Molecular Weight of Alpha Cyclodextrin ... Alpha-cyclodextrin is widely used in the drugs, food, flavor and cosmetics. Alpha-cyclodextrin is also widely used in the field ...
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Alpha CyclodextrinAlpha Cyclodextrin

Be free to buy quality alpha cyclodextrin made in China with our factory. ... Qianhui Biological is one of professional alpha cyclodextrin manufacturers and suppliers in China with rich experience. ... Natural Cyclodextrin Main Beta Cyclodextrin Derivatives Other Beta Cyclodextrin Derivatives Alpha Cyclodextrin Derivatives ... High Standard Daily Chemical Field Additives Alpha Cyclodextrin. Name: alpha-cyclodextrin Other name : α-cyclodextrin ; ...
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Sulfobutylether Alpha CyclodextrinSulfobutylether Alpha Cyclodextrin

Be free to buy quality sulfobutylether alpha cyclodextrin made in China with our factory. ... Qianhui Biological is one of professional sulfobutylether alpha cyclodextrin manufacturers and suppliers in China with rich ... Natural Cyclodextrin Main Beta Cyclodextrin Derivatives Other Beta Cyclodextrin Derivatives Alpha Cyclodextrin Derivatives ... Sulfobutylether Alpha Cyclodextrin. *. Contact Us. Pharmaceutical Grade Excipients Embedding Medium Sulfobutylether Alpha ...
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Essential Dietary Fiber - Alpha Cyclodextrin - Nuvexa - Inhibits Fat A - Being Well EssentialsEssential Dietary Fiber - Alpha Cyclodextrin - Nuvexa - Inhibits Fat A - Being Well Essentials

Essential Dietary Fiber - Alpha Cyclodextrin - Nuvexa - Inhibits Fat Absorption - 180 tablets - FREE US SHIPPING. Default Title ... FBCx®** Alpha-cyclodextrin 2 g*. Other ingredients: Croscarmellose sodium, stearic acid, magnesium stearate, silicon dioxide, ... Home › Essential Dietary Fiber - Alpha Cyclodextrin - Nuvexa - Inhibits Fat Absorption - 180 tablets - FREE US SHIPPING ... Essential Dietary Fiber contains the soluble fiber alpha-cyclodextrin, patented as FBCx®. Decades of preclinical and clinical ...
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PDF] Correlation of polymer-like solution behaviors with electrospun fiber formation of hydroxypropyl-β-cyclodextrin and the...PDF] Correlation of polymer-like solution behaviors with electrospun fiber formation of hydroxypropyl-β-cyclodextrin and the...

... aggregates were one of the most important factors that significantly influenced fiber formation during cyclodextrin ... the formation of hydroxypropyl-β-cyclodextrin (HPCD) nanofibers in electrospinning and the adsorption of organic molecules on ... Electrospinning of cyclodextrins: hydroxypropyl-alpha-cyclodextrin nanofibers. *Asli Celebioglu, Tamer Uyar. *Materials Science ... Electrospun Fibers of Cyclodextrins and Poly(cyclodextrins). *Alejandro Costoya, Angel Concheiro, Carmen Alvarez-Lorenzo ...
more infohttps://www.semanticscholar.org/paper/Correlation-of-polymer-like-solution-behaviors-with-Zhang-Chen/280d9e2fb36e44a87dc04799bdec25c83620035e

Weight Loss - Life ExtensionWeight Loss - Life Extension

Alpha-Cyclodextrin. Researchers have identified a natural fiber called alpha-cyclodextrin that selectively absorbs and ... Studies showed if alpha-cyclodextrin were taken three times daily during high-fat meals (2 g per meal), it could engulf as much ... Moreover, alpha-cyclodextrin has been shown to selectively reduce unhealthy fats while leaving alone the safer fats. In a ... Unlike conventional dietary fiber, which non-selectively binds fat in about a 1:1 ratio, a single gram of alpha-cyclodextrin is ...
more infohttps://www.lifeextension.com/protocols/Metabolic-Health/Weight-Loss

104326-94-5 - 3-Chloro-2-fluorobenzamide, 97+% - B24162 - Alfa Aesar104326-94-5 - 3-Chloro-2-fluorobenzamide, 97+% - B24162 - Alfa Aesar

alpha-Cyclodextrin, 97+%. * A11118. 2,2-Dipyridyl disulfide, 98%. * 35600. Potassium hydrogen iodate, 0.025N Standardized ...
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Fiber Food Ingredients in the U.S.:  Soluble, Insoluble, and Digestive-Resistant Types, 2nd Edition : Market ReportFiber Food Ingredients in the U.S.: Soluble, Insoluble, and Digestive-Resistant Types, 2nd Edition : Market Report

Alpha-cyclodextrin Arabinogalactan Beta-glucan Bran Cellulose Chicory Root Fiber Chitosan Dextrin Fiber Fructooligosaccharide ( ...
more infohttps://www.packagedfacts.com/Sitemap/Product/6710826

Innovative fiber improves metabolic health. - Free Online LibraryInnovative fiber improves metabolic health. - Free Online Library

... alpha-cyclodextrin , Report) by Life Extension; Health, general Cyclodextrins Health aspects Usage Metabolism ... HOW ALPHA-CYCLODEXTRIN FIBER MOLECULES WORK The capacity of the natural fiber alpha-cyclodextrin to selectively absorb ... Alpha-Cyclodextrin Reduces Unhealthy Fats Japanese researchers have been investigating alpha-cyclodextrin for 30 years since ... Scientists have identified a natural fiber called alpha-cyclodextrin that lowers after-meal glucose and insulin surges. Alpha- ...
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Patent US5352717 - Adhesives and sealants - Google PatentsPatent US5352717 - Adhesives and sealants - Google Patents

Where the complex of cyclodextrin and blowing agent is employed, an expandable mixture is formed. ... adhesion is provided by incorporating into an adhesive and/or sealant plastic material an effective amount of cyclodextrin or a ... Suitably, the cyclodextrins used in the present invention are alpha, beta or gamma cyclodextrin. Beta cyclodextrin is preferred ... A six membered ring is called alpha cyclodextrin; seven, beta cyclodextrin, and eight, gamma cyclodextrin. These six, seven and ...
more infohttp://www.google.com/patents/US5352717?dq=inventor:%22Arthur+R.+Hair%22&ei=VAy0Tsa4NYTl0QGQiqWiBA

Hypercholesterolemia - Pipeline Review, H1 2014 Market Research ReportHypercholesterolemia - Pipeline Review, H1 2014 Market Research Report

Alpha Cyclodextrin - Drug Profile 69. Product Description 69. Mechanism of Action 69. R&D Progress 69. evolocumab - Drug ...
more infohttps://www.researchmoz.us/hypercholesterolemia-pipeline-review-h1-2014-report.html

Cyclomaltodextrin glucanotransferase precursor - Bacillus circulansCyclomaltodextrin glucanotransferase precursor - Bacillus circulans

DB01909 Alpha-Cyclodextrin (Cyclohexa-Amylose). DB03773 alpha-D-quinovopyranose. DB02379 Beta-D-Glucose. DB03323 Maltose. ... DB01909 Alpha-Cyclodextrin (Cyclohexa-Amylose). DB03773 alpha-D-quinovopyranose. DB02379 Beta-D-Glucose. DB03323 Maltose. ... PF00128 Alpha-amylase, 1 hit. PF02806 Alpha-amylase_C, 1 hit. PF00686 CBM_20, 1 hit. PF01833 TIG, 1 hit. ... PF00128 Alpha-amylase, 1 hit. PF02806 Alpha-amylase_C, 1 hit. PF00686 CBM_20, 1 hit. PF01833 TIG, 1 hit. ...
more infohttps://www.uniprot.org/uniprot/P30920

JPH04327570A - Alkyl ether carboxylic acid tauride 
      - Google PatentsJPH04327570A - Alkyl ether carboxylic acid tauride - Google Patents

Diglucosyl-alpha-cyclodextrin and its production JPH03271295A (en) 1991-12-03. Production of aluminoxane ...
more infohttps://patents.google.com/patent/JPH04327570A/en

Neuroblastoma | GreenMedInfo | Disease | Natural MedicineNeuroblastoma | GreenMedInfo | Disease | Natural Medicine

The use of moringin with alpha-cyclodextrin complex may open novel perspectives to improve the poor prognosis of patients with ... Pharmacological Actions : Anti-Inflammatory Agents, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha Inhibitor ...
more infohttp://www.greenmedinfo.com/disease/neuroblastoma
  • Unlike lipase inhibitors, alpha-cyclodextrin forms a stable complex with the dietary fat which prevents lipase from digesting the triglyceride and the normal gut flora from using it as a carbon source, thus preventing the side effects of the lipase inhibitors. (wikipedia.org)
  • full citation needed] According to these authors, the number of cyclodextrin molecules per fatty acid appears to be dependent upon the length of the fatty acids that are involved. (wikipedia.org)
  • full citation needed][full citation needed] α-Cyclodextrin is a multifunctional, soluble dietary fiber marketed for use as a fiber ingredient, an odor or flavor masking agent as well as for emulsification applications. (wikipedia.org)
  • There are two other naturally occurring cyclodextrins, β (beta) - and γ (gamma) -, which contain seven and eight glucose units respectively. (wikipedia.org)
  • As the molecular weight of the fiber and triglycerides are about the same, it would appear to follow that the cyclodextrin is actually forming a layer on the surface of the fat droplets. (wikipedia.org)
  • Lower blood (LDL or bad) low-density lipoprotein cholesterol levels Lower blood triglyceride levels Preferentially lowers blood saturated fat and trans fat levels Increased insulin sensitivity Increased leptin sensitivity - increased satiety[full citation needed] Improved glycemic index of foods and improved glycemic control Due to its surface active properties, α-cyclodextrin can also be used as an emulsifying fiber, for example in mayonnaise. (wikipedia.org)
  • Alpha-Fibe is the original product that contains this unique fiber, introduced to the worldwide nutritional supplement market by Bio-Form Essentials in 2007. (wikipedia.org)
  • Due to the small pore size it was generally believed that α-cyclodextrin could not form a complex with triglyceride. (wikipedia.org)
  • for example, demonstrated that α-cyclodextrin was very effective at solubilizing the free fatty acids that are generated in the colorimetric determination of triglycerides. (wikipedia.org)
  • α-Cyclodextrin is marketed for a range of medical, healthcare and food and beverage applications which rely on its ability to bind to fats and reduce their bioavailability both in the body and in food and beverage products. (wikipedia.org)
  • medical citation needed] Animal and human studies are consistent with each other in demonstrating the positive benefits of taking alpha-cyclodextrin fiber. (wikipedia.org)
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