AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Progesterone CongenersCrystallinsalpha-CrystallinsLens, Crystallinebeta-Crystallin B Chainbeta-Crystallin A Chaingamma-Crystallinsbeta-CrystallinsRicinalpha-Crystallin A Chainalpha-Crystallin B Chaindelta-CrystallinsCataractMolecular Sequence DataAmino Acid SequenceAbrinBungarusBase SequencePolymerase Chain Reactionalpha 1-AntitrypsinMacromolecular Substances
Progesterone Congeners
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
Crystallins
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.
alpha-Crystallins
A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Lens, Crystalline
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
beta-Crystallin B Chain
The basic subunit of beta-crystallins.
beta-Crystallin A Chain
The acidic subunit of beta-crystallins.
gamma-Crystallins
A subclass of crystallins that found in the lens (LENS, CRYSTALLINE) of VERTEBRATES. Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. They are composed of monomeric subunits.
beta-Crystallins
A class of crystallins that provides refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits.
Ricin
A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.
alpha-Crystallin A Chain
One of the subunits of alpha-crystallins. Unlike ALPHA-CRYSTALLIN B CHAIN the expression of ALPHA-CRYSTALLIN A CHAIN is limited primarily to the lens (LENS, CRYSTALLINE).
alpha-Crystallin B Chain
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
delta-Crystallins
A subclass of crystallins found in the lens (LENS, CRYSTALLINE) in BIRDS and REPTILES. They are inactive forms of the enzyme argininosuccinate lyase.
Cataract
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Abrin
A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.
Bungarus
A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. They comprise the kraits. Twelve species are recognized and all inhabit southeast Asia. They are considered extremely dangerous. (Moore: Poisonous Snakes of the World, 1980, p120)
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
alpha 1-Antitrypsin
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Macromolecular Substances
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.

Alterations in the mouse and human proteome caused by Huntington's disease. (1/314)

Huntington's disease is an autosomal dominantly inherited disease that usually starts in midlife and inevitably leads to death. In our effort to identify proteins involved in processes upstream or downstream of the disease-causing huntingtin, we studied the proteome of a well established mouse model by large gel two-dimensional electrophoresis. We could demonstrate for the first time at the protein level that alpha1-antitrypsin and alphaB-crystalline both decrease in expression over the course of disease. Importantly, the alpha1-antitrypsin decrease in the brain precedes that in liver and testes in mice. Reduced expression of the serine protease inhibitors alpha1-antitrypsin and contraspin was found in liver, heart, and testes close to terminal disease. Decreased expression of the chaperone alphaB-crystallin was found exclusively in the brain. In three brain regions obtained post-mortem from Huntington's disease patients, alpha1-antitrypsin expression was also altered. Reduced expression of the major urinary proteins not found in the brain was seen in the liver of affected mice, demonstrating that the disease exerts its influence outside the brain of transgenic mice at the protein level. Maintaining alpha1-antitrypsin and alphaB-crystallin availability during the course of Huntington's disease might prevent neuronal cell death and therefore could be useful in delaying the disease progression.  (+info)

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. (2/314)

Myoblasts respond to growth factor deprivation either by differentiating into multinucleated myotubes or by undergoing apoptosis; hence, the acquisition of apoptosis resistance by myogenic precursors is essential for their development. Here we demonstrate that the expression of the small heat shock protein alpha B-crystallin is selectively induced in C2C12 myoblasts that are resistant to differentiation-induced apoptosis, and we show that this induction occurs at an early stage in their differentiation in vitro. In contrast, the expression of several known anti-apoptotic proteins (FLIP, XIAP, Bcl-x(L)) was not altered during myogenesis. We also demonstrate that ectopic expression of alpha B-crystallin, but not the closely related small heat shock protein Hsp27, renders C2C12 myoblasts resistant to differentiation-induced apoptosis. Furthermore, we show that the myopathy-causing R120G alpha B-crystallin mutant is partly impaired in its cytoprotective function, whereas a pseudophosphorylation alpha B-crystallin mutant that mimics stress-induced phosphorylation is completely devoid of anti-apoptotic activity. Finally, we demonstrate that alpha B-crystallin negatively regulates apoptosis during myogenesis by inhibiting the proteolytic activation of caspase-3, whereas the R120G and pseudophosphorylation mutants are defective in this function. Taken together, our findings indicate that alpha B-crystallin is a novel negative regulator of myogenic apoptosis that directly links the differentiation program to apoptosis resistance.  (+info)

Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genes. (3/314)

The mouse Shsp/alphaB-crystallin and Mkbp/HspB2 genes are closely linked and divergently transcribed. In this study, we have analyzed the contribution of the intergenic enhancer to Shsp/alphaB-crystallin and Mkbp/HspB2 promoter activity using dual-reporter vectors in transient transfection and transgenic mouse experiments. Deletion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 30- and 93-fold and Mkbp/HspB2 promoter activity by 6- and 10-fold in transiently transfected mouse lens alpha-TN4 and myoblast C2C12 cells, respectively. Surprisingly, inversion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 17-fold, but did not affect Mkbp/HspB2 promoter activity in the transfected cells. In contrast, enhancer activity was orientation-independent in combination with a heterologous promoter in transfected cells. Transgenic mouse experiments established the orientation dependence and Shsp/alphaB-crystallin promoter preference of the intergenic enhancer in its native context. The orientation dependence and preferential effect of the Shsp/alphaB-crystallin enhancer on the Shsp/alphaB-crystallin promoter provide an example of adaptive changes in gene regulation accompanying the functional diversification of duplicated genes during evolution.  (+info)

Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. (4/314)

PURPOSE: The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the expression of the small heat shock protein alphaB-crystallin in the RPE in response to oxidative stress and to explore whether alphaB-crystallin expression confers an antiapoptotic cytoprotective effect on RPE cells. METHODS: Native human RPE cells from the macula and retinal periphery were analyzed by RT-PCR and Western blot analysis for expression of alphaB-crystallin. Monolayer cultures of human RPE cells were stressed by heat shock (42 degrees C for 20 minutes) or oxidant-mediated injury (50-300 micro M H(2)O(2) for 1 hour). Induction of alphaB-crystallin and the corresponding mRNA was assessed by Western and Northern blot analyses. To study the cytoprotective effect of alphaB-crystallin, human RPE cells were transfected with either a neomycin-selectable expression vector containing alphaB-crystallin cDNA or a control vector without alphaB-crystallin cDNA. Caspase-3 activity was determined by observing the cleavage of a colorimetric peptide substrate. Cell viability was quantified by combined propidium iodide and Hoechst 33342 staining. RESULTS: alphaB-crystallin is constitutively expressed in RPE under in vivo and in vitro conditions. Western blot analysis of freshly isolated RPE showed greater baseline expression levels in RPE derived from the macular area than in that from the more peripheral regions. Heat shock treatment and oxidative stress caused a significant increase in alphaB-crystallin mRNA and protein. Oxidant-mediated injury in RPE cells with baseline expression levels of alphaB-crystallin resulted in apoptotic cell death, as measured by caspase-3 activity, whereas RPE cells that had been stably transfected with alphaB-crystallin were more resistant to H(2)O(2)-induced cellular injury. CONCLUSIONS: alphaB-crystallin may function as a stress-inducible antiapoptotic protein in human RPE and is inducible by oxidative stress, a condition implicated in the pathogenesis of AMD. Overexpression of alphaB-crystallin may be an important mechanism for the RPE to prevent apoptotic cell death in response to cellular stress.  (+info)

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination. (5/314)

AlphaB-crystallin is a small heat-shock protein in which three serine residues (positions 19, 45, and 59) can be phosphorylated under various conditions. We describe here the interaction of alphaB-crystallin with FBX4, an F-box-containing protein that is a component of the ubiquitin-protein isopeptide ligase SCF (SKP1/CUL1/F-box). The interaction with FBX4 was enhanced by mimicking phosphorylation of alphaB-crystallin at both Ser-19 and Ser-45 (S19D/S45D), but not at other combinations. Ser-19 and Ser-45 are preferentially phosphorylated during the mitotic phase of the cell cycle. Also alphaB-crystallin R120G, a mutant found to co-segregate with a desmin-related myopathy, displayed increased interaction with FBX4. Both alphaB-crystallin S19D/S45D and R120G specifically translocated FBX4 to the detergent-insoluble fraction and stimulated the ubiquitination of one or a few yet unknown proteins. These findings implicate the involvement of alphaB-crystallin in the ubiquitin/proteasome pathway in a phosphorylation- and cell cycle-dependent manner and may provide new insights into the alphaB-crystallin-induced aggregation in desmin-related myopathy.  (+info)

Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of two-mode binding in alphaB-crystallin. (6/314)

The consequences of alphaB-crystallin phosphorylation on its chaperone activity were investigated using a detailed analysis of the recognition and binding of destabilized T4 lysozyme (T4L) mutants by alphaB-crystallin phosphorylation mimics containing combinations of serine to aspartate substitutions. The T4L site-directed mutants were selected to constitute an energetic ladder of progressively destabilized proteins having similar structures in the folded state. alphaB-crystallin and its variants differentially recognize the T4L mutants, binding the more destabilized ones to a larger extent. Furthermore, the aspartate substitutions result in an increase in the extent of binding to the same T4L mutant and in the appearance of biphasic binding isotherms. The latter indicates the presence of two modes of binding characterized by different affinities and different numbers of binding sites. The transition to two-mode binding can also be induced by temperature or pH activation of the second mode. The similarity between the phosphorylation, pH, and temperature effects suggests a common structural origin. The location of the phosphorylation sites in the N-terminal domain and the hypothesized burial of this domain in the core of the oligomeric structure are consistent with a critical role for the destabilization of the quaternary structure in the process of recognition and binding by small heat-shock proteins.  (+info)

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. (7/314)

BACKGROUND: One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO). METHODS: Lenses from 129SvEvTac mice and alpha A/BKO mice were examined by standard scanning electron microscopy and confocal microscopy methodologies. RESULTS: Equatorial and axial (sagittal) dimensions of lenses for alpha A/BKO mice were significantly smaller than age-matched wild type lenses. No posterior sutures or fiber cells extending to the posterior capsule of the lens were found in alpha A/BKO lenses. Ectopical nucleic acid staining was observed in the posterior subcapsular region of 5 wk and anterior subcapsular cortex of 54 wk alpha A/BKO lenses. Gross morphological differences were also observed in the equatorial/bow, posterior and anterior regions of lenses from alpha A/BKO mice as compared to wild mice. CONCLUSION: These results indicated that both alpha A- and alpha B-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation.  (+info)

Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. (8/314)

AlphaB-crystallin (alphaBC), a small heat shock protein expressed in high levels in the heart, is phosphorylated on Ser-19, 45, and 59 after stress. However, it is not known whether alphaBC phosphorylation directly affects cell survival. In the present study, constructs were prepared that encode forms of alphaBC harboring Ser to Ala (blocks phosphorylation) or Ser to Glu (mimics phosphorylation) mutations at positions 19, 45, and 59. The effects of each form on apoptosis of cultured cardiac myocytes after hyperosmotic or hypoxic stress were assessed. Compared with controls, cells that expressed alphaBC with Ser to Ala substitutions at all three positions, alphaBC(AAA), exhibited more stress-induced apoptosis. Cells expressing either alphaBC(AAE) or (EEE) exhibited 3-fold less apoptosis than cells expressing alphaBC(AAA), indicating that phosphorylation of Ser-59 confers protection. alphaBC is known to bind to procaspase-3 and to decrease caspase-3 activation. Compared with cells expressing alphaBC(AAA), the activation of caspase-3 was decreased by 3-fold in cells expressing alphaBC(AAE). These results demonstrate that mimicking the phosphorylation of alphaBC on Ser-59 is necessary and sufficient to confer caspase-3 inhibition and protection of cardiac myocytes against hyperosmotic or hypoxic stress. These findings provide direct evidence that alphaBC(S59P) contributes to the cardioprotection observed after physiologically relevant stresses, such as transient hypoxia. Identifying the targets of alphaBC(S59P) will reveal important details about the mechanism underlying the cytoprotective effects of this small heat shock protein.  (+info)

alphaB-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progressionalphaB-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression
The molecular chaperone alphaB-crystallin has emerged as a target for cancer therapy due to its expression in human tumors and its role in regulating tumor angiogenesis. alphaB-crystallin also reduces neuroinflammation, but its role in other inflammatory conditions has not been investigated. Here, we examined whether alphaB-crystallin regulates inflammation associated with tumors and ischemia. We found that CD45(+) leukocyte infiltration is 3-fold increased in tumors and ischemic myocardium in alphaB-crystallin-deficient mice. Notably, alphaB-crystallin is prominently expressed in CD11b(+) Gr-1(+) immature myeloid cells (IMCs), known as regulators of angiogenesis and immune responses, while lymphocytes and mature granulocytes show low alphaB-crystallin expression. alphaB-Crystallin deficiency results in a 3-fold higher accumulation of CD11b(+) Gr-1(+) IMCs in tumors and a significant rise in CD11b(+) Gr-1(+) IMCs in spleen and bone marrow. Similarly, we noted a 2-fold increase in CD11b(+) ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:865888
Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the...Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the...
Expression of small stress proteins (shsp) enhances the survival of mammalian cells exposed to heat or oxidative injuries. Recently, we have shown that the expression of shsp from different species, such as human hsp27, Drosophila hsp27 or human alphaB-crystallin protected murine L929 cells against …
https://pubmed.ncbi.nlm.nih.gov/8654367/?dopt=Abstract
Browse our CRYAB ELISA KitsBrowse our CRYAB ELISA Kits
Order CRYAB ELISA Kits for many Reactivities. Chicken, Cow, Dog and more. Compare CRYAB ELISA Kits and find the right product on antibodies-online.com.
http://www.antibodies-online.com/abstract/Crystallin%2C+alpha+B+
P. de Ronsard; Oeuvres Poétiques: Index Alphabétique (French Edition) Vaganay, Hugues » holypet.ruP. de Ronsard; Oeuvres Poétiques: Index Alphabétique (French Edition) Vaganay, Hugues » holypet.ru
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http://holypet.ru/p-de-ronsard-oeuvres-po-tiques-index-alphab-tique-french-edition-vaganay-hugues
Liste alphabétique des applications, logiciels et plateformes SAPListe alphabétique des applications, logiciels et plateformes SAP
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IU School of Medicine discovery may lead to precision-based strategy for triple negative breast cancerIU School of Medicine discovery may lead to precision-based strategy for triple negative breast cancer
INDIANAPOLIS - Unlike the three most common forms of breast cancer, triple negative breast cancer has no currently approved targeted therapies for treatment. That was one of the reasons it was chosen as a disease area of focus for the Indiana University Grand Challenge Precision Health Initiative, aimed to research and develop better treatments, cures or preventions, as quickly as possible.. Xiongbin Lu, PhD, a researcher in the Vera Bradley Foundation Center for Breast Cancer Research at Indiana University School of Medicine, working in collaboration with researchers from the University of Maryland, recently reported several important findings related to triple negative breast cancer and its treatment future, in the prestigious journal Nature Nanotechnology.. According to the paper now available online, TP53 is the most frequently mutated gene in triple negative breast cancer, meaning it is fueling the growth of this aggressive form of breast cancer. However, the problem with trying to target ...
https://medicine.iu.edu/news/2019/03/iu-school-of-medicine-discovery-may-lead-to-precision-based-strategy-for-triple-negative-breast-cancer
Mitochondrial Dysfunction and Apoptosis Underlie the Pathogenic Process in α-B-Crystallin Desmin-Related Cardiomyopathy |...Mitochondrial Dysfunction and Apoptosis Underlie the Pathogenic Process in α-B-Crystallin Desmin-Related Cardiomyopathy |...
Desmin-related myopathy is a subgroup of myofibrillar myopathy caused by mutations in desmin, CryAB, and other proteins that interact with the intermediate filaments. The pathology is characterized by myofibril disruption that appears to initiate at the Z-disk. Dislocation and aggregation of membranous organelles is observed as well as the accumulation of the mutant, misfolded desmin, and/or CryAB into insoluble aggregates, which gradually increase in the cytoplasm and are thought to eventually result in cell death.1-3 We previously showed that these aggregates may be classified as aggresomes, whose accumulation is often associated with neurodegenerative diseases caused by protein misfolding or unfolding.8 Our studies showed that the aggresomes present in the cardiomyocytes contain large concentrations of a toxic amyloid oligomer, which is typically found in many of the amyloid-based neurodegenerative diseases. The data thus link these cardiomyopathies to a broad class of amyloid-based ...
http://circ.ahajournals.org/content/112/22/3451.long
Abstract 258: Human 450delACryAB Overexpression Associated with Protein Aggregation Uncovers a Novel Mechanism for Inheritable...Abstract 258: Human 450delACryAB Overexpression Associated with Protein Aggregation Uncovers a Novel Mechanism for Inheritable...
Desmin-related cardiomyopathy (DRC) belongs to the family of myofibrillar diseases characterized by the presence of toxic desmin-positive aggregates and degeneration at Z-disk structures. DRC has been linked to the mutations in the desmin, αBcrystallin (CryAB), or myotilin genes. Several human CryAB mutations cause multisystem disorders and experimental models of R120GCryAB in transgenic mice strikingly recapitulate similar phenotype observed in patients. In this context, we have generated the 450delACryAB linked to inheritable cataracts in neonatal rat cardiomyocytes and mice hearts. 450delACryAB formed aggregates or aggresomes, and recruited HSP25 into the insoluble fraction in the cardiomyocytes. However, heart-specific 450delA CryAB overexpression neither causes desmin-related cardiomyopathy nor exacerbates pressure overload-induced hypertrophy. To our knowledge, this is the first report of compensation to protein aggregates formation abrogates the development of cardiomyopathy and suggests ...
http://circres.ahajournals.org/content/111/Suppl_1/A258
A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy. - PubMed - NCBIA missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/9731540?dopt=Abstract
Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide<...Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide<...
TY - JOUR. T1 - Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide. AU - Yang, Seung Won. AU - Lee, Seung Min. AU - Choi, Eun Young. AU - Lee, Kyung Hye. AU - Kim, Soo Hyuk. AU - Shin, Min Jeong. AU - Han, Ye Sun. AU - Kang, Seok Min. AU - Chung, Ji Hyung. PY - 2011/9/1. Y1 - 2011/9/1. N2 - Cell-penetrating peptides (CPPs), including TAT-CPP, have been used to deliver exogenous proteins into living cells. Although a number of proteins fused to TAT-CPP can be delivered into various cells, little is known about the proteolytic cleavage of TAT-fusion proteins in cells. In this study, we demonstrate that a small heat shock protein (sHSP), alphaB-crystallin (αB-crystallin), delivered by TAT-CPP is susceptible to proteolytic cleavage by matrix metalloproteinase-1 (MMP-1) in cardiac myoblast H9c2 cells. Recombinant TAT-αB-crystallin was efficiently transduced into H9c2 cells. For a few hours following protein transduction, generation of ...
https://yonsei.pure.elsevier.com/en/publications/matrix-metalloproteinase-1-induces-cleavage-of-exogenous-alphab-c
Active H2 :: Oxidative Stress
Not surprisingly, the body can also suffer from reductive stress which frequently goes unmentioned. Reductive stress is achieved when the concentrations of reducing agents exceeds that of oxidizing agents. This is commonly encountered with the metabolism of ethanol. It is therefore possible for Health Fanatics to overdose on anti-oxidants and push the body into reductive stress instead of the oxidative stress they are steadfastly trying to avoid. Exercise can have positive or negative effects with regard to Redox effects on the body according to how it is performed. Exercise increases oxidative stress due to metabolic processes but when exercise is undertaken on a regular basis the body up-regulates its own anti-oxidant capacity to cope with the increased demand. This improved anti-oxidant activity clearly has additional benefits when we are not exercising but are under oxidative stress in other ways. Intermittent exercise will increase the oxidative stress burden on the body but is not ...
https://serw.org/oxidative-stress
Reductive Stress: An Argument Against Anti-Oxidants for Athletes & Everyone Else? Plus: AGE-Reduced Diets for Health & Weight...Reductive Stress: An Argument Against Anti-Oxidants for Athletes & Everyone Else? Plus: AGE-Reduced Diets for Health & Weight...
Accordingly, its important to look beyond the ostensibly obvious results like low AGE diets promote fat and weight loss. While this may be true, even the cursory analysis of the study results in todays SuppVersity short news indicates that the obvious conclusion that reducing AGEs would mechanistically reduce body fat is probably flawed. Rather than that people who avoid high AGE foods will necessary avoid foods with high energy density, consume less energy and lose weight in response to a reduction in energy intake - not in response to the reduced intake of AGEs. Problems like these are why it is important to look beyond the conclusions in the abstracts and / or come back to the SuppVersity regularly for short and in-depth analyses of the latest studies , Comment on Facebook ...
https://suppversity.blogspot.com/2014/11/reductive-stress-argument-against-anti.html
The Probabilities of Oddities : Jeffrey RosenthalThe Probabilities of Oddities : Jeffrey Rosenthal
Jeffrey Rosenthal - Jeffrey Rosenthal earned his PhD in mathematics from Harvard at just 24 years old. From there, he became a professor in the department of statistic...
https://www.trendhunter.com/keynote/jeffrey-rosenthal
Linda Rosenthal · Change.orgLinda Rosenthal · Change.org
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https://www.change.org/decision-makers/linda-rosenthal
Lehnes Pharmacology for Nursing Care, 10th Ed., Burchum & Rosenthal, 2019 - Picmonic for Nursing RNLehnes Pharmacology for Nursing Care, 10th Ed., Burchum & Rosenthal, 2019 - Picmonic for Nursing RN
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https://www.picmonic.com/pathways/nursing/books/lehnes-pharmacology-for-nursing-care-10th-ed-burchum-rosenthal-2019-6881?scroll_to=content
Clinical Studies in Medical Biochemistry - Hardcover - Robert H. Glew; Miriam D. Rosenthal - Oxford University PressClinical Studies in Medical Biochemistry - Hardcover - Robert H. Glew; Miriam D. Rosenthal - Oxford University Press
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https://global.oup.com/academic/product/clinical-studies-in-medical-biochemistry-9780195176872?cc=us&lang=en
Alexander Disease, symptoms and Alexander Disease treatmentsAlexander Disease, symptoms and Alexander Disease treatments
Learn about Alexander Disease and other health conditions at HealtheTreatment. What is Alexander Disease? Compare Alexander Disease symptoms Alexander Disease treatments and . Share online in the health community.
http://www.healthetreatment.com/condition/alexander-disease/
P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic...
TY - JOUR. T1 - P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress. AU - Su, Huabo. AU - Wang, Xuejun. PY - 2011/11/1. Y1 - 2011/11/1. N2 - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.. AB - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated ...
https://augusta.pure.elsevier.com/en/publications/p62-stages-an-interplay-between-the-ubiquitin-proteasome-system-a
CRYAB - WikipediaCRYAB - Wikipedia
Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications decrease the ability to chaperone. Defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and ...
https://en.wikipedia.org/wiki/CRYAB
Alexander Disease - National Stem Cell FoundationAlexander Disease - National Stem Cell Foundation
Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause progressive degeneration of the white matter of the brain due…
https://nationalstemcellfoundation.org/glossary/alexander-disease/
Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by...
BACKGROUND: We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient, and severe motor-neuron disease (MND) in her half-brother, the brain Magnetic Resonance Imaging (MRI) features were compatible with adult-onset Alexanders disease (AOAD), suggesting different expression of the same, genetically determined, condition.METHODS: Since mutations in the alpha isoform of glial fibrillary acidic protein, GFAP-α, the only cause so far known of AOAD, were excluded, we applied exome Next Generation Sequencing (NGS) to identify gene variants, which were then functionally validated by molecular characterization of recombinant and patient-derived cells.RESULTS: Exome-NGS revealed a mutation in a previously neglected GFAP isoform, GFAP-ϵ, which disrupts the GFAP-associated ...
http://www.mrc-mbu.cam.ac.uk/publications/1180/adult-onset-alexander-disease-associated-mutation-alternative-gfap-transcript-may
Pepco NewsPepco News
Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called glial cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
http://www.pepconet.com/blog/page/4
Reductive stress | Department of BiologyReductive stress | Department of Biology
A representation of NAD showing the change that occurs in the nicotinamide moiety (encircled) when NAD+ is reduced to NADH. In NAD+, the nicotinamide moiety has a planar structure, whereas it is puckered in NADH as shown in this animation (avi).. In facultative aerobic bacteria the catabolism of fuel molecules is associated with the reduction of NAD+ to NADH. During the transition to oxygen limited growth, an increased level of NADH builds up, as it is less efficiently reoxidized to NAD+ as a result of reduced aerobic respiration. These roles of NADH and NAD+ provide a link between energy homeostasis and gene regulation. In most Gram-positive bacteria a novel sensor of the NAD redox balance is present. This transcriptional repressor is called Rex (from redox; Figure 2). Transcription of Rex-repressed genes in Bacillus subtilis is activated when oxygen is limiting for aerobic respiration, and as a consequence the levels of free NADH increase. This leads to production of cytochrome bd (a ...
https://www.biology.lu.se/research/research-groups/microbiology-group/research-projects/bacterial-stress-responses/reductive-stress
R120G αB-crystallin promotes the unfolding of reduced α-lactalbumin an by T. M. Treweek, A. Rekas et al.R120G αB-crystallin promotes the unfolding of reduced α-lactalbumin an by T. M. Treweek, A. Rekas et al.
α-Crystallin is the principal lens protein which, in addition to its structural role, also acts as a molecular chaperone, to prevent aggregation and precipitation of other lens proteins. One of its two subunits, αB-crystallin, is also expressed in many non-lenticular tissues, and a natural missense mutation, R120G, has been associated with cataract and desminrelated myopathy, a disorder of skeletal muscles (Vicart et al., 1998, Nature Genet. 20:92-95). In the present study, real-time 1H NMR spectroscopy showed that the ability of R120G αB-crystallin to stabilize the partially folded, molten globule state of α- lactalbumin was significantly reduced in comparison with wild type αB-crystallin. The mutant showed enhanced interaction with, and promoted unfolding of reduced α- lactalbumin, while it showed limited chaperone activity for other target proteins. Using NMR spectroscopy, gel electrophoresis and mass spectrometry (MS) it was observed that, unlike the wild type protein, R120G αB-crystallin is
http://ro.uow.edu.au/scipapers/71/
Rosenthal Name Meaning, Family History, Family Crest & Coats of ArmsRosenthal Name Meaning, Family History, Family Crest & Coats of Arms
See the Rosenthal surname, family crest & coat of arms. Free Search. Uncover the Rosenthal surname history for the German Origin. What is the history of the last name Rosenthal?
https://www.houseofnames.com/rosenthal-family-crest
Novelties | Rosenthal Porcelain Online ShopNovelties | Rosenthal Porcelain Online Shop
Order Novelties online - Discover 770 Novelties from the Rosenthal brand environments and collections. Purchase your porcelain and more from the Rosenthal Porcelain Online Shop.
https://www.rosenthal.de/en/novelties-2/?page_number=3
Novelties | Rosenthal Porcelain Online ShopNovelties | Rosenthal Porcelain Online Shop
Order Novelties online - Discover 780 Novelties from the Rosenthal brand environments and collections. Purchase your porcelain and more from the Rosenthal Porcelain Online Shop.
https://www.rosenthal.de/en/novelties-2/?page_number=4
ATGen (182400) Company Profile - CorporateInformation.comATGen (182400) Company Profile - CorporateInformation.com
ATGen operates in the Commercial Physical Research sector. ATGen is a Korea-based company principally engaged in developing and manufacturing reagent used for experimentation . The Companys product portfolio consists of recombination proteins including binding immunoglobulin protein, carboxy terminus of HSP70 interacting protein, BCL2-associated athanogene 2; monoclonal antibodies including 14-3-3 beta antibody, A crystallin A antibody , alpha-crystallin B and NK Vue Kit used for physical examination and diagnosis. The Company distributes its products within domestic market and to overseas markets.
http://www.corporateinformation.com/Company-Snapshot.aspx?cusip=C410CR710
Rosenthal - the Malibu Estate - Tasting Room and VineyardRosenthal - the Malibu Estate - Tasting Room and Vineyard
The Rosenthal Malibu winery holds a variety of year-round Malibu wine tasting events. We offer special VIP access for members and a variety of wines online.
https://rosenthalestatewines.com/?date=2017-11-14&t=list
Rosenthal - The Malibu Estate - Tasting Room and VineyardRosenthal - The Malibu Estate - Tasting Room and Vineyard
The Rosenthal Malibu winery holds a variety of year-round Malibu wine tasting events. We offer special VIP access for members and a variety of wines online.
http://rosenthalestatewines.com/malibu-tasting-room/?date=2017-6&t=mini
Dr. Howard Rosenthal, DDS - Newtown, PA - Dentistry | Healthgrades.comDr. Howard Rosenthal, DDS - Newtown, PA - Dentistry | Healthgrades.com
Visit Healthgrades for information on Dr. Howard Rosenthal, DDS Find Phone & Address information, medical practice history, affiliated hospitals and more.
https://www.healthgrades.com/dentist/dr-howard-rosenthal-xqs9w
Dr. Robert Rosenthal, MD - Rockwall, TX - Emergency Medicine & Family Medicine | Healthgrades.comDr. Robert Rosenthal, MD - Rockwall, TX - Emergency Medicine & Family Medicine | Healthgrades.com
Visit Healthgrades for information on Dr. Robert Rosenthal, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
https://www.healthgrades.com/physician/dr-robert-rosenthal-2dkvx
The Pleasant Trees - Tom Rosenthal | Last.fmThe Pleasant Trees - Tom Rosenthal | Last.fm
Listen free to Tom Rosenthal - The Pleasant Trees (Its OK, Going To be Wonderful and more). 6 tracks (16:49). Discover more music, concerts, videos, and pictures with the largest catalogue online at Last.fm.
https://www.last.fm/music/Tom+Rosenthal/The+Pleasant+Trees
Protocols and Video Articles Authored by Nikolai Rosenthal (Translated to Hebrew)Protocols and Video Articles Authored by Nikolai Rosenthal (Translated to Hebrew)
Nikolai Rosenthal is the author of this article in the Journal of Visualized Experiments: תכנון ויישום מערכת עצבים בסימולציות לגו רובוטים
https://www.jove.com/author/Nikolai_Rosenthal?language=Hebrew
New Money | Lorraine Zago Rosenthal | MacmillanNew Money | Lorraine Zago Rosenthal | Macmillan
A young Southern woman of modest means suddenly finds herself thrust into New Yorks high society when she discovers that she is the illegitimate daughter of...
http://us.macmillan.com/excerpt?isbn=9781250025357
Alpha-Crystallins Regulate DNA Damage Pathway to Prevent Stress-Induced Apoptosis of Human Lens Epithelial Cells | IOVS | ARVO...Alpha-Crystallins Regulate DNA Damage Pathway to Prevent Stress-Induced Apoptosis of Human Lens Epithelial Cells | IOVS | ARVO...
Purpose: : In our previous studies, we have demonstrated that alpha-crystallins can negatively regulate stress-induced apoptosis through suppression of the ERK-mediated pathway and activation of the AKT signaling pathway. In the present study, we present evidence to show that alpha-crystallins can regulate the ATR-p53 pathway to prevent UVA-induced apoptosis. Methods: : UVA was used to irradiate human lens epithelial cells stably expressing vector, alphaA, and alphaB. Western blot analysis was used for detection of ATR, CHK1/2 and p53 activation. Reporter gene activity assay was used to explore the transactivity of p53. Hoechst staining was used for apoptosis assay. Results: : Human lens epithelial cells expressing either alphaA- or alphaB-crystallin are substantially resistant to UVA-induced apoptosis. UVA-induces activation of ATR and CHK1/2 kinases to activate p53 in vector-transfected cells. However, in alphaA- or alphaB-crystallin-transfected cells, activation of ATR, CHK1/2 kinases and p53 ...
http://iovs.arvojournals.org/article.aspx?articleid=2367547
Alexander disease - WikipediaAlexander disease - Wikipedia
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
https://en.wikipedia.org/wiki/Alexander_disease
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. - openThiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. - open
Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD(+)/NADH and NADP(+)/NADPH. The development of these biofilms requires DNA, RNA and protein synthesis. Transcriptional analysis suggests that Mtb modulates only ∼7% of its genes for survival in biofilms. In addition to proteins, lipids and DNA, the extracellular material in these biofilms is primarily composed of polysaccharides, with cellulose being a key component. Our results contribute to a better understanding of the mechanisms underlying Mtb biofilm formation, although the clinical relevance of Mtb biofilms in human tuberculosis remains ...
http://crdd.osdd.net/open/1908/
Genetic variation of alphaB-crystallin in multiple sclerosis, hypertrophic cardiomyopathy and dilated cardiomyopathy</em>...Genetic variation of alphaB-crystallin in multiple sclerosis, hypertrophic cardiomyopathy and dilated cardiomyopathy</em>...
TY - BOOK. T1 - Genetic variation of alphaB-crystallin in multiple sclerosis, hypertrophic cardiomyopathy and dilated cardiomyopathy. AU - Støvring, Birgitte. PY - 2009. Y1 - 2009. M3 - Ph.D. thesis. BT - Genetic variation of alphaB-crystallin in multiple sclerosis, hypertrophic cardiomyopathy and dilated cardiomyopathy. PB - Roskilde Universitet. CY - Roskilde. ER - ...
https://forskning.ruc.dk/da/publications/genetic-variation-of-alphab-crystallin-in-multiple-sclerosis-hype
Diamond Publications - Search Results
Abstract: Small heat shock proteins form large cytosolic assemblies from an α-crystallin domain (ACD) flanked by sequence extensions. Mutation of a conserved arginine in the ACD of several human small heat shock protein family members causes many common inherited diseases of the lens and neuromuscular system. The mutation R120G in αB-crystallin causes myopathy, cardiomyopathy and cataract. We have solved the X-ray structure of the excised ACD dimer of human αB R120G close to physiological pH and compared it with several recently determined wild-type vertebrate ACD dimer structures. Wild-type excised ACD dimers have a deep groove at the interface floored by a flat extended bottom sheet. Solid-state NMR studies of large assemblies of full-length αB-crystallin have shown that the groove is blocked in the ACD dimer by curvature of the bottom sheet. The crystal structure of R120G ACD dimer also reveals a closed groove, but here the bottom sheet is flat. Loss of Arg120 results in rearrangement of ...
https://publications.diamond.ac.uk/pubman/searchpublicationsadvanced?advancedsearch=1&authorId=7273&publicationStates%5B4%5D.selected=true
DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21)DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21)
DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_DNAJC21.html
DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4)DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4)
DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_DNAJC4.html
Reductive stress linked to hea...( SALT LAKE CITY -- Antioxidants are wid...)
Health,...SALT LAKE CITY -- Antioxidants are widely considered an important defe...The findings published in the Aug. 10 issue of Cell indicate a new c...The protein alpha B-Crystallin termed a molecular chaperone normally...In a study of laboratory mice with failing hearts caused by mutant alp...,Reductive,stress,linked,to,heart,disease,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
http://news.bio-medicine.org/medicine-news-3/Reductive-stress-linked-to-heart-disease-49-1/
Elucidating a Precise Role for the Small Heat Shock Proteins CryAB and HspB2 in Cardiac RobustnessElucidating a Precise Role for the Small Heat Shock Proteins CryAB and HspB2 in Cardiac Robustness
The eleven students involved learned basic experimental design (with positive and negative controls), troubleshooting, a wide variety of laboratory techniques, and data collection, analysis and presentations skills. In addition, students learned to read and analyze scientific work from other labs since they are given scientific articles to read beginning on their first day in the lab. This project is in collaboration with Ivor Benjamin M.D., Ph.D. at the University of Utah, which allowed these students the unique opportunity of discussing their research with a larger audience once a month. In addition to intellectual enrichment, students learned to function as a team, with those more experienced (graduate students Kelsey Langston and Whitney Hayes) mentoring those who are new in the lab. As students progressed in their understanding of the project and mastery of basic laboratory skills, they become involved in planning our weekly group meeting, preparing figures for presentations/publications, ...
http://jur.byu.edu/?p=18099
Hspb11 MGI Mouse Gene Detail - MGI:1920188 - heat shock protein family B (small), member 11Hspb11 MGI Mouse Gene Detail - MGI:1920188 - heat shock protein family B (small), member 11
View mouse Hspb11 Chr4:107253593-107279938 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
http://www.informatics.jax.org/marker/MGI:1920188
Alexander diseaseAlexander disease
A slowly progressive and ultimately fatal brain disorder that most commonly occurs in children. The infantile form of the disease is characterized by megalencephaly (an abnormally large head), seizures, spasticity and developmental retardation.…
https://medicine.academic.ru/276/Alexander_disease
Albee Messing VMD, PhDAlbee Messing VMD, PhD
Alexander disease (AxD) is a primary genetic disorder of astrocytes caused by dominant mutations in the gene encoding the intermediate filament (IF) protein GFAP. This disease is characterized by excessive accumulation of GFAP, known as Rosenthal fibers, within astrocytes.
https://www.waisman.wisc.edu/2017/04/03/albee-messing/
Curated InformationCurated Information
Singh BN, Rao KS, Rao ChM (2010) Ubiquitin-proteasome-mediated degradation and synthesis of MyoD is modulated by alphaB-crystallin, a small heat shock protein, during muscle differentiation. Biochim Biophys Acta 1803, 288-99 20005263 ...
https://www.phosphosite.org/curatedInfoAction.action?record=12028115
Hungarian physicians in Vienna: Móric Rosenthal, József Grünfeld, Sándor Spitzer - GeoScience.netHungarian physicians in Vienna: Móric Rosenthal, József Grünfeld, Sándor Spitzer - GeoScience.net
Emed, A.; Rosenthal, Móricz.; Grünfeld, József.; Spitzer, Sándor., 2003: Hungarian physicians in Vienna: Móric Rosenthal, József Grünfeld, Sándor Spitzer
https://geoscience.net/research/049/254/049254919.php
Dr. Norman Rosenthal, MD, Psychiatry Specialist - Rockville, MD | SharecareDr. Norman Rosenthal, MD, Psychiatry Specialist - Rockville, MD | Sharecare
Dr. Norman Rosenthal, MD is a psychiatry specialist in Rockville, MD. Dr. Rosenthal completed a residency at Ny State Psychology Institute. He currently practices at Capital Clinical Research Assocs.
https://www.sharecare.com/doctor/norman-rosenthal-1
Helianthus annuus hsp17.6 G1 protein Summary Report | CureHunterHelianthus annuus hsp17.6 G1 protein Summary Report | CureHunter
Helianthus annuus hsp17.6 G1 protein: a small heat-shock protein from sunflower; amino acid sequence in first source; GenBank Z95153
http://www.curehunter.com/public/keywordSummaryC108947-Helianthus-annuus-hsp17-6-G1-protein.do
Dr. Alexander at ISNVD endothelial researcherDr. Alexander at ISNVD endothelial researcher
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
http://www.thisisms.com/forum/chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic19275.html
Rosenthal, K. S.<...
Mikecz, K., Glant, T. T., Markovics, A., Rosenthal, K. S., Kurko, J., Carambula, R. E., Cress, S., Steiner, H. L. & Zimmerman, D. H., Jul 13 2017, In : Vaccine. 35, 32, p. 4048-4056 9 p.. Research output: Contribution to journal › Article ...
https://augusta.pure.elsevier.com/en/persons/kenneth-steven-rosenthal
Reviews | Dr. Randall Rosenthal, MD | Newport, RI | Obstetrician & GynecologistReviews | Dr. Randall Rosenthal, MD | Newport, RI | Obstetrician & Gynecologist
Read ratings and reviews for Dr. Randall Rosenthal who has 28 years of experience as a Obstetrician & Gynecologist in Newport, RI.
https://www.vitals.com/doctors/Dr_Randall_Rosenthal/reviews
Determinant selection and macrophage function in genetic control of th by A S. RosenthalDeterminant selection and macrophage function in genetic control of th by A S. Rosenthal
Rosenthal, A S., Determinant selection and macrophage function in genetic control of the immune response. (1978). Subject Strain Bibliography 1978. 3821 ...
https://mouseion.jax.org/ssbb1978/3821/
CSIR - Centre for Cellular & Molecular Biology
Heat-stress induced alterations in localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for ?B-crystallin and hsp ...
http://www.ccmb.res.in/index.php?view=publications&mid=128&id=68&grpid=9
HSPA2 Gene - GeneCards | HSP72 Protein | HSP72 AntibodyHSPA2 Gene - GeneCards | HSP72 Protein | HSP72 Antibody
Complete information for HSPA2 gene (Protein Coding), Heat Shock Protein Family A (Hsp70) Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=HSPA2
A Dialogue between Alexander the Great, and Diogenes the Cynic - Wikisource, the free online libraryA Dialogue between Alexander the Great, and Diogenes the Cynic - Wikisource, the free online library
WHAT fellow art thou, who darest thus to lie at thy ease in our presence, when all others, as thou seest, rise to do us homage? dost thou not know us?. Diog. I cannot say I do: but by the number of thy attendants, by the splendour of thy habit; but, above all, by the vanity of thy appearance, and the arrogance of thy speech, I conceive thou mayst be Alexander the son of Philip.. Alex. And who can more justly challenge thy respect, than Alexander, at the head of that victorious army, who hath performed such wonderful exploits, [1] and, under his conduct, hath subdued the world?. Diog. Who? why the tailor who made me this old cloke.. Alex. Thou art an odd fellow, and I have a curiosity to know thy name.. Diog. I am not ashamed of it: I am called Diogenes: a name composed of as many and as well-sounding syllables as Alexander.. Alex. Diogenes, I rejoice at this encounter. I have heard of thy name, and been long desirous of seeing thee; in which wish, since fortune hath accidentally favoured me, I ...
https://en.wikisource.org/wiki/A_Dialogue_between_Alexander_the_Great,_and_Diogenes_the_Cynic
HSPA13 (human) | Gene Target - PubChemHSPA13 (human) | Gene Target - PubChem
Gene target information for HSPA13 - heat shock protein family A (Hsp70) member 13 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
https://pubchem.ncbi.nlm.nih.gov/gene/6782
Tracy L. Hagemann, PhD & Albee Messing, VMD, PhD - Slide of the WeekTracy L. Hagemann, PhD & Albee Messing, VMD, PhD - Slide of the Week
Alexander disease results from gain of function mutations in the gene encoding glial fibrillary acidic protein (GFAP). At least eight GFAP isoforms have been described, however, the predominant alpha isoform accounts for approximately 90% of GFAP protein.
https://www.waisman.wisc.edu/2020/03/06/hagemann-slide-of-the-week-2020/
Publications - He LabPublications - He Lab
Chen X, Lin S, Liu Q, Huang J, Zhang W, Lin J, Wang Y, Ke Y, He H. Expression and interaction of small heat shock proteins (sHsps) in rice in response to heat stress. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2014, 1844 (4): 818-828. ...
http://bioinformatics.fafu.edu.cn/?page_id=14
MySQL Lists: commits: bzr commit into mysql-trunk branch (alexander.barkov:3365) WL#946MySQL Lists: commits: bzr commit into mysql-trunk branch (alexander.barkov:3365) WL#946
At file:///home/bar/mysql-bzr/mysql-trunk-wl946/ based on revid:[email protected] 3365 Alexander Barkov 2011-05-18 WL#946: fixing some test failures. As the datatype of @@timestamp has changed from Sys_var_session_special (ulonglong based) to Sys_var_session_special_double (double bases), its not any more correct to use ~(time_t)0 as the upper limit parameter to constructor. modified: sql/sys_vars.cc === modified file sql/sys_vars.cc --- a/sql/sys_vars.cc 2011-05-18 17:21:03 +0000 +++ b/sql/sys_vars.cc 2011-05-18 19:59:19 +0000 @@ -2730,7 +2730,7 @@ static bool check_timestamp(sys_var *sel static Sys_var_session_special_double Sys_timestamp( timestamp, Set the time for this client, sys_var::ONLY_SESSION, NO_CMD_LINE, - VALID_RANGE(0, ~(time_t)0), BLOCK_SIZE(1), + VALID_RANGE(0, TIMESTAMP_MAX_VALUE + 1), BLOCK_SIZE(1), NO_MUTEX_GUARD, IN_BINLOG, ON_CHECK(check_timestamp), ON_UPDATE(update_timestamp), ON_READ(read_timestamp)); Attachment: [text/bzr-bundle] ...
https://lists.mysql.com/commits/137554
2009 Dodge Avenger for Sale in Alexander City, AL 35010 - Autotrader2009 Dodge Avenger for Sale in Alexander City, AL 35010 - Autotrader
Find 2009 Dodge Avenger for sale in Alexander City, AL. Find car prices, photos, and more. Locate Alexander City, AL car dealers and find your car at Autotrader!
https://www.autotrader.com/cars-for-sale/2009/Dodge/Avenger/Alexander+City+AL-35010
Mercedes-Benz SLR for Sale in Alexander City, AL 35010 - AutotraderMercedes-Benz SLR for Sale in Alexander City, AL 35010 - Autotrader
Find Mercedes-Benz SLR for sale in Alexander City, AL. Find car prices, photos, and more. Locate Alexander City, AL car dealers and find your car at Autotrader!
https://www.autotrader.com/cars-for-sale/Mercedes-Benz/SLR/Alexander+AL-35010
Alexander Semeonov - MOOC transcript, reviews, and interests | Class CentralAlexander Semeonov - MOOC transcript, reviews, and interests | Class Central
View Alexander Semeonovs MOOC Record on Class Central. Class Central profile pages makes it easy for you to learn about Alexander Semeonovs interests in MOOCs.
https://www.class-central.com/u/38674
Alexander Wahba - NTNU
Smenes, Benedikte Therese; Pettersen, Øystein; Stenseth, Roar; Karlsen, Øystein; Wahba, Alexander. (2017) Evaluering av phase of care mortality analysis og failure to rescue i en Norsk thoraxkirurgisk klinikk. Vitenskapelige forhandlinger / De norske kirurgiske foreninger. vol. 93. ...
https://www.ntnu.edu/employees/alexander.wahba
Alexander Khovanov - NHL - DraftSite.comAlexander Khovanov - NHL - DraftSite.com
Player profile for Alexander Khovanov (C). See what DraftSite and fans have to say about Khovanov. Submit your own scouting profile & videos.
https://www.draftsite.com/nhl/player/alexander-khovanov/29200/
Geometry by Its History by Gerhard Wanner, Alexander Ostermann (Paperback, 2014) | eBayGeometry by Its History by Gerhard Wanner, Alexander Ostermann (Paperback, 2014) | eBay
Find great deals for Geometry by Its History by Gerhard Wanner, Alexander Ostermann (Paperback, 2014). Shop with confidence on eBay!
https://www.ebay.co.uk/p/Geometry-by-its-History-by-Gerhard-Wanner-Alexander-Ostermann-Paperback-2014/209384932
Thermo-Poroelasticity and Geomechanics by Alexander Suvorov, A. P. S. Selvadurai (Hardback, 2016) | eBayThermo-Poroelasticity and Geomechanics by Alexander Suvorov, A. P. S. Selvadurai (Hardback, 2016) | eBay
Find great deals for Thermo-Poroelasticity and Geomechanics by Alexander Suvorov, A. P. S. Selvadurai (Hardback, 2016). Shop with confidence on eBay!
https://www.ebay.co.uk/p/Thermo-Poroelasticity-and-Geomechanics-by-Alexander-Suvorov-A-P-S-Selvadurai-Hardback-2016/228924268
Category:Alexander Blok - Wikimedia CommonsCategory:Alexander Blok - Wikimedia Commons
Aleksandr Blok (es); Александр Александрович Блок (kk-kz); Alexander Blok (en-gb); Александър Блок (bg); الیگزینڈر بلوک (pnb); الکساندربلوک (ur); Aleksandr Blok (sv); Блок Олександр Олександрович (uk); 亞歷山大·勃洛克 (zh-hant); 亚历山大·勃洛克 (zh-cn); Aleksandr Blok (uz); Александр Александрович Блок (kk); Aleksandro Blok (eo); Александар Блок (mk); আলেক্সান্দ্‌র ব্লক‌ (bn); Alexandre Blok (fr); Aleksander Aleksandrovič Blok (hr); अलेक्झांडर ब्लॉक (mr); Aleksander Aleksandrowič Blok (hsb); Aleksandr Aleksandrovich Blok (vi); الەكساندر الەكساندروۆىيتش بلوك (kk-arab); Aleksandrs Bloks (lv); Александар Блок (sr); Aleksandr Blok (pt-br); 亚历山大·勃洛克 (zh-sg); Александр Александрович Блок (kk-cyrl); Aleksandr ...
https://commons.wikimedia.org/wiki/Category:Alexander_Blok
Movie Review: How It Ends (2018) | The Ü ReviewsMovie Review: How It Ends (2018) | The Ü Reviews
How It Ends (dir. David M. Rosenthal, 2018) - After a mysterious event sends the world into chaos, two men set out on a desperate drive to find their missing family.VerdictHow It Ends itself is as much of a disappointment as how it actually ends.ReviewAn unsettling disruption cuts short a call between Will (Theo James)…
https://theuumlaut.wordpress.com/2018/07/31/review-how-it-ends-2018/
EuRBPDB
Staub E, Fiziev P, Rosenthal A, Hinzmann B; , Bioessays 2004;26:567-581.: Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. PUBMED:15112237 EPMC:15112237. ...
http://eurbpdb.syshospital.org/rbp_genelist.php?domain=DBP10CT&species=Macaca_mulatta
Publications scientifiques | CépiDcPublications scientifiques | CépiDc
Lewden C, May T, Rosenthal E, Burty C, Bonnet F, Costagliola D, et al. Changes in causes of death among adults infected by HIV between 2000 and 2005: The Mortalité 2000 and 2005 surveys (ANRS EN19 and Mortavic). J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):590-8 ...
https://cepidc.inserm.fr/publications-scientifiques?f%5B0%5D=annee%3A48&f%5B1%5D=annee%3A61&f%5B2%5D=annee%3A537&f%5B3%5D=annee%3A565&f%5B4%5D=langues%3A84
Publications scientifiques | CépiDcPublications scientifiques | CépiDc
Lewden C, May T, Rosenthal E, Burty C, Bonnet F, Costagliola D, et al. Changes in causes of death among adults infected by HIV between 2000 and 2005: The Mortalité 2000 and 2005 surveys (ANRS EN19 and Mortavic). J Acquir Immune Defic Syndr. 2008 Aug 15;48(5):590-8 ...
https://cepidc.inserm.fr/publications-scientifiques?f%5B0%5D=annee%3A61&f%5B1%5D=annee%3A126&f%5B2%5D=annee%3A537&f%5B3%5D=annee%3A565&f%5B4%5D=annee%3A644&f%5B5%5D=langues%3A84
Ilena Rosenthals Defamation of Terry Polevoy
Ilena Rosenthal used Tim Bolens defamatory posts to target Terry Polevoy, MD for destruction. Its now in the hands of the California courts for final disposition.
http://www.healthwatcher.net/Quackerywatch/Hulda_Clark/Rosenthal/index.html
CRYAACRYAA
Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Crystallins are separated into two classes: ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an ...
https://en.wikipedia.org/wiki/CRYAA
CRYABCRYAB
... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Alpha B chain crystallins (αBC) can be induced by heat shock, ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. These ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein ...
https://en.wikipedia.org/wiki/CRYAB
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate dehydrogenase MeSH D12.776.377.715.085.050 - alpha 1- ... immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - immunoglobulin alpha-chains MeSH D12.776.377.715.548.705. ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
CRYBB2CRYBB2
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as ... "Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2 ... Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four ... Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene. Crystallins are separated into two classes: taxon ...
https://en.wikipedia.org/wiki/CRYBB2
Chromosome 1Chromosome 1
Crystallin zeta CYP4B1 (1p33) CYR61 (1p22) DBT: dihydrolipoamide branched chain transacylase E2 DCLRE1B: DNA cross-link repair ... encoding protein Sterile alpha motif domain containing 11 SDC3: Syndecan-3 SDHB (1p36) SFPQ (1p34) SGIP1: SH3 domain GRB2-like ... 1 alpha subcomplex, 4, 9kda, pseudogene 1 NGF: Nerve Growth Factor NOL9: Nucleolar protein 9 NRAS (1p13) NOTCH2 (1p12) OLFML3: ... encoding TNF alpha induced protein 8 like 2 TNFSF18 (1q25) TNN (1q25) TNNT2: cardiac troponin T2 TOR1AIP1: Torsin-1A- ...
https://en.wikipedia.org/wiki/Chromosome_1
Chromosome 21Chromosome 21
... encoding alpha-2 chain of collagen VI COL18A1: encoding alpha-1 chain of collagen XVIII CRYAA: encoding alpha-crystallin A ... encoding GA-binding protein alpha chain GART: encoding enzyme trifunctional purine biosynthetic protein adenosine-3 GATD3A: ... encoding interferon alpha/beta receptor 1 IFNAR2: encoding interferon alpha/beta receptor 2 IFNGR1: encoding interferon gamma ... chain CRYZL1: Crystallin zeta-like 1 CXADR: encoding protein coxsackievirus and adenovirus receptor CYYR1: Cysteine and ...
https://en.wikipedia.org/wiki/Chromosome_21
Aldo-keto reductaseAldo-keto reductase
... rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide ... Some proteins of this family contain a potassium channel beta chain regulatory domain; these are reported to have ... The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in ...
https://en.wikipedia.org/wiki/Aldo-keto_reductase
Pathophysiology of multiple sclerosisPathophysiology of multiple sclerosis
Bsibsi M, Holtman IR, Gerritsen WH, Eggen BJ, Boddeke E, van der Valk P, van Noort JM, Amor S (2013). "Alpha-B-Crystallin ... free light chains (FLC). Several authors have reported that they are comparable or even better than oligoclonal bands. Multiple ...
https://en.wikipedia.org/wiki/Pathophysiology_of_multiple_sclerosis
PerlecanPerlecan
The N-terminal domain I (aa ~1-195) contains attachment sites for HS chains. Although HS chains are not required for correct ... To this end, a transgenic mouse line was created expressing porcine TGF-β1 under the lens-specific αA-crystallin promoter and ... In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain ... Domain V also has attachment sites for HS/CS chains. Thus, perlecan core protein and HS chains could modulate matrix assembly, ...
https://en.wikipedia.org/wiki/Perlecan
List of A1 genes, proteins or receptorsList of A1 genes, proteins or receptors
... alpha 1 Collagen, type XIX, alpha 1 Collagen, type XXV, alpha 1 Collagen, type XXVII, alpha 1 Crystallin, beta A1 Cyclic ... DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein NADH ... alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ...
https://en.wikipedia.org/wiki/List_of_A1_genes,_proteins_or_receptors
Protein footprintingProtein footprinting
Shum WK, Maleknia SD, Downard KM (September 2005). "Onset of oxidative damage in alpha-crystallin by radical probe mass ... The rate or level of oxidation at the reactive amino acid side chains (Met, Cys, Trp, Tyr, Phe, His, Pro and Leu) provides a ... The mechanisms of side chain oxidation were explored by performing the radiolysis reactions in 18O-labeled water. A critical ... Downard KM, Kokabu Y, Ikeguchi M, Akashi S (November 2011). "Homology-modelled structure of the βB2B3-crystallin heterodimer ...
https://en.wikipedia.org/wiki/Protein_footprinting
AgeingAgeing
The cause is lens hardening by decreasing levels of alpha-crystallin, a process which may be sped up by higher temperatures. ... The authors propose that mtDNA mutations lead to respiratory-chain-deficient cells and thence to apoptosis and cell loss. They ... the Growth hormone/Insulin-like growth factor 1 signalling pathway the activity levels of the electron transport chain in ...
https://en.wikipedia.org/wiki/Ageing
Protease inhibitor (biology)Protease inhibitor (biology)
The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... is a double-chain inhibitor consisting of an 11-residue and a 41-residue chain. The Carboxypeptidase inhibitor I68 family ... The yeast killer toxin structure was thought to be a precursor of the two-domain beta gamma-crystallin proteins, because of its ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ...
https://en.wikipedia.org/wiki/Protease_inhibitor_(biology)
Argininosuccinate lyaseArgininosuccinate lyase
Domain 2 contains one small beta sheet, nine alpha helices, and the carboxyl terminus. Three of the nine alpha helices on one ... δ-crystallins are the major structural eye lens water-soluble proteins of most birds, reptiles, and some other vertebrates. ... ASL is composed of four identical monomers; each monomer consisting of a single polypeptide chain between 49 and 52 kDa, ... Two dimers then associate by way of alpha helix, one from each monomer, to form a central 20-helix core. The association of all ...
https://en.wikipedia.org/wiki/Argininosuccinate_lyase
Sean M. DecaturSean M. Decatur
Silva, R.A.G.D., *Nguyen, J.Y., and Decatur, S.M. (2002) "Probing the Effects of Side Chains on the Conformation and Stability ... "Formation of Amyloid Fibrils in Vitro by Human γd-crystallin and its Isolated Domains," Molecular Vision 14:81-89. Decatur, S.M ... "Two dimensional infrared measurements of the coupling of the amide modes of an alpha helix," Chemical Physics Letters 382: 586- ... "Twodimensional IR Spectroscopy and Segmental 13C Labeling reveals the Domain Structure of Human γδ-crystallin amyloid fibrils ...
https://en.wikipedia.org/wiki/Sean_M._Decatur
GlucosepaneGlucosepane
These compounds are thought to act as bidentate nucleophiles that attack the adjacent carbonyls in the alpha-dicarbonyl ... and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane ... This then condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the ... such as collagen in the skin and crystallin in the eyes. Skin collagen, for instance, has a half-life of fifteen years. Because ...
https://en.wikipedia.org/wiki/Glucosepane
Charles Daniel LaneCharles Daniel Lane
The translation of reticulocyte 9S RNA in frog oocytes gives rise to alpha and beta globin chains. Communication to FEBS ... Berns, A. J. M.; Kraaikamp, M. Van; Bloemendal, H.; Lane, C. D. (1972). "Calf Crystallin Synthesis in Frog Cells: The ...
https://en.wikipedia.org/wiki/Charles_Daniel_Lane
List of MeSH codes (D08)List of MeSH codes (D08)
... cholesterol side-chain cleavage enzyme MeSH D08.244.453.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.244.453.915 ... delta-crystallins MeSH D08.811.520.232.400 - ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811 ... cholesterol side-chain cleavage enzyme MeSH D08.811.682.690.708.170.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH ... cholesterol 7 alpha-hydroxylase MeSH D08.811.682.690.708.783.212 - cholesterol side-chain cleavage enzyme MeSH D08.811.682.690. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
TransketolaseTransketolase
... and aspartate side-chains, with a glutamate side-chain playing a secondary role. These side-chains, to be specific Arg359, ... and Asp477 forms hydrogen bonds with the alpha hydroxyl group on the substrate, where it works to effectively bind the ... in the mammalian cornea by the stromal keratocytes and epithelial cells and is reputed to be one of the corneal crystallins. ... To be specific, the His 263 and His30 side-chains form hydrogen bonds to the aldehyde end of the substrate, which is deepest ...
https://en.wikipedia.org/wiki/Transketolase
List of distinct cell types in the adult human bodyList of distinct cell types in the adult human body
... alpha and gamma-endorphin, bombesin Thyroid gland cells Thyroid epithelial cell Parafollicular cell Parathyroid gland cells ... Intermediate skeletal muscle cell Nuclear bag cell of muscle spindle Nuclear chain cell of muscle spindle Myosatellite cell ( ... Medium spiny neurons Astrocytes Oligodendrocytes Ependymal cells Tanycytes Pituicytes Anterior lens epithelial cell Crystallin- ... Parathyroid chief cell Oxyphil cell Pancreatic islets (islets of Langerhans) Alpha cell (secretes glucagon) Beta cell (secretes ...
https://en.wikipedia.org/wiki/List_of_distinct_cell_types_in_the_adult_human_body
ProteinopathyProteinopathy
Ecroyd H, Carver JA (January 2009). "Crystallin proteins and amyloid fibrils". Cellular and Molecular Life Sciences. 66 (1): 62 ... Badar T, D'Souza A, Hari P (2018). "Recent advances in understanding and treating immunoglobulin light chain amyloidosis". ... "Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein". Proceedings of the ... In immunoglobulin light chain amyloidosis (AL amyloidosis), chemotherapy can be used to lower the number of the blood cells ...
https://en.wikipedia.org/wiki/Proteinopathy
Amyloid betaAmyloid beta
"Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the ... Oligomerization is a chemical process that converts individual molecules into a chain consisting of a finite number of ... Intra-cellular deposits of tau protein are also seen in the disease, and may also be implicated, as has aggregation of alpha ... leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in ...
https://en.wikipedia.org/wiki/Amyloid_beta
alpha-Crystallin B Chain/genetics/*physiology | Glembotski..."alpha-Crystallin B Chain/genetics/*physiology" | Glembotski...
"alpha-Crystallin B Chain/genetics/*physiology". Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ...
https://www.glembotskilab.org/tag/alpha-crystallin-b-chain/genetics/physiology/
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBioAnti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio
HSPB8 , Alpha-crystallin C chain , CMT2L , Crystallin alpha c , DHMN2 , E2-induced gene 1 protein , CRYAC , E2IG1 , HMN2 , H11 ...
https://www.lsbio.com/antibodies/hspb8-antibody-h11-antibody-hsp22-antibody-clone-oti1e3-flow-if-immunofluorescence-wb-western-ls-c337133/347744
Light scattering of human lens vesicles in vitroLight scattering of human lens vesicles in vitro
... was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. Increased ... The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. Hydrocarbon chain ... lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid ...
https://pubmed.ncbi.nlm.nih.gov/12697424/
GlyConnectGlyConnect
32 Alpha crystallin - a and b chains Bos taurus P02510 # id : 32 Alpha crystallin - a and b chains Bos taurus ... 33 Alpha crystallin - a and b chains Homo sapiens P02489 # id : 33 Alpha crystallin - a and b chains Homo sapiens ... 34 Alpha crystallin - a and b chains Rattus norvegicus P24623 # id : 34 Alpha crystallin - a and b chains Rattus norvegicus ... Alpha crystallin - a and b chains / Bos taurus P02470 P02510 # Export GlyConnect protein list related to protein with id 32 ...
https://glyconnect.expasy.org/o-monosaccharide/proteins?n=0
GlyConnectGlyConnect
Alpha crystallin b chain (b2 subunit) (Bos taurus). All glycosylation sites SNFG, Text, Oxford ... Alpha crystallin b chain (b2 subunit) / Bos taurus P02510 # Export GlyConnect protein list related to glycosylation_site_ ... structure with id 3800000008849 P02510 # id : 38 Alpha crystallin b chain (b2 subunit) Bos taurus ... Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (1991 - Roquemore E, Dell A, Hart G) / Status : ...
https://glyconnect.expasy.org/o-monosaccharide/proteins/38/sites
GeniePlex Rat LIX/GCP2/CXCL5 Multiplex AssayGeniePlex Rat LIX/GCP2/CXCL5 Multiplex Assay
Rat Alpha-crystallin A chain (Cryaa) ELISA KitProduct Code:RTEB0981Alias:Alpha-crystallin A chain, Cryaa,... ...
https://www.assaygenie.com/genieplex-rat-lix-gcp2-cxcl5-immunoassay/
DeCSDeCS
alpha-Crystallin B Chain Entry term(s). B Chain, alpha-Crystallin B Subunit alpha-Crystallin Crystallins, alpha B Chain ... alpha B Crystallin alpha B-Crystallin alpha Crystallin B Chain alpha Crystallin, B Subunit alpha-Crystallin, B Subunit ... alpha B Crystallin. alpha B-Crystallin. alpha Crystallin B Chain. alpha Crystallin, B Subunit. alpha-Crystallin, B Subunit. ... Chaîne B de la cristalline alpha Entry term(s):. B Chain, alpha-Crystallin. B Subunit alpha-Crystallin. Crystallins, alpha B ...
https://decs.bvsalud.org/en/ths/resource/?id=37441
Infantile muscular dystrophy in Canadian aboriginals is an αb-crystallinopathy<...
Crystallins Medicine & Life Sciences 72% * alpha-Crystallin B Chain Medicine & Life Sciences 48% ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ...
https://mayoclinic.pure.elsevier.com/en/publications/infantile-muscular-dystrophy-in-canadian-aboriginals-is-an-%CE%B1b-cry
IMSEAR at SEARO: Search
1 alpha-Crystallin A Chain --isolat.... *. next > Date issued. *1 2010 - 2011 ... Lens proteome map and -crystallin profile of the catfish Rita rita.. Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas ...
https://imsear.searo.who.int/handle/123456789/1364/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=subject&filter_type_1=equals&filter_value_1=Mice&etal=0&filtername=subject&filterquery=Cattle&filtertype=equals
CRYAB Antibody Monoclonal | HSPB5 Antibody | ProSpecCRYAB Antibody Monoclonal | HSPB5 Antibody | ProSpec
Alpha crystallins are composed of two gene products; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Mouse IgG2b heavy chains and κ light chain.. Purification Method. CRYAB antibody was purified from mouse ascitic fluids by ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of -crystallins are an autokinase ... Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. ...
https://www.prospecbio.com/cryab_antibody
Pesquisa | Prevenção e Controle de CâncerPesquisa | Prevenção e Controle de Câncer
... alpha 1; CRYBA1: crystallin, beta A1; DAPI: 46-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: ... ferritin heavy chain 1; GPX: glutathione peroxidase; GST: glutathione S-transferase; H2O2: hydrogen peroxide; His280: histidine ... Herein, we demonstrate an important role for ßA3/A1-crystallin in RPE. ßA3/A1-crystallin deficiency leads to clathrin-mediated ... We found that ßA3/A1-crystallin binds to phosphatidylinositol transfer protein (PITPß) and that ßA3/A1-crystallin deficiency ...
https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=au:Grebe,+Rhonda
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
collagen type IV alpha 6 chain. protein-coding. CXXC5. CXXC finger protein 5. protein-coding. ... crystallin alpha B. protein-coding. CDC42EP4. CDC42 effector protein 4. protein-coding. ... C3 and PZP like, alpha-2-macroglobulin domain containing 8. protein-coding. ...
https://www.genscript.com/gene/9823/sus-scrofa?search=c
PDGF-ABELISA檢測試劑盒價格48T/96T-上海一研生物
晶狀體蛋白αA檢測試劑盒Alpha-crystallin A chain 定做種屬檢測試劑盒/中藥材鑒定試劑盒
http://www.sb1516.com/Products-33078575.html
KIT - IBG2Teaching and Seminars - Group Seminar - Past group seminarsKIT - IBG2Teaching and Seminars - Group Seminar - Past group seminars
Polydisperse alpha B-crystallin - About termini and finding the right groove". 20.05 Thilo Mast (Vertiefer student). "Synthese ... Synthesis of photoswitchable side-chain stapled helical peptides. 22.05. Volodymyr Kubyshkin (TU Berlin). What can proline ... "Analysis of the orientation of fluor-labeled amino acid side chains at various positions. inside peptides via molecular ... "Rekombinante Expression des Transmembransegments de T-Zell Receptors alpha". Papia Sanyal. "Promotion, inhibition and killing ...
https://www.ibg.kit.edu/nmr/902.php
DeCS 2016 - June 12, 2016 versionDeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs.bvs.br/I/DeCS2016_Alfab-B.htm
ORF Clones: Search resultORF Clones: Search result
Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA.. A8610. ... Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 2, mRNA.. A7467. ... Homo sapiens crystallin alpha A (CRYAA), mRNA.. D0373. NM_013501.3. Cryaa. Acry-1, Crya-1, Crya1, DAcry-1, lop18. Mouse. Mus ... Mus musculus crystallin, alpha A (Cryaa), transcript variant 1, mRNA.. Mm36859. NM_001278570.1. Cryaa. Acry-1, Crya-1, Crya1, ...
https://www.genecopoeia.com/product/search/result.php?key=CRYAA&prt=25&field=0
cataract | Leaders in Pharmaceutical Business Intelligence (LPBI) Groupcataract | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the ... The amino acid sequences of the a-crystallin A and B chains of the dogfish, Squalus acanthias, have been determined. Comparison ... some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene ... Speculation emerged that these structures were thin filaments with bound alpha crystallin particles, or nucleosomes on DNA, but ...
https://pharmaceuticalintelligence.com/tag/cataract/
aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológicaaa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica
Recombination and identification of human alpha B-crystallin.. *. Preston. To recombine the human alpha B-crystallin (αB- ... A Guide to Cloning the Products of Polymerase Chain Reactions. *. Preston. This introduction outlines varied strategies to ... human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, ... Due to the benefit with which the termini of amplified DNAs will be tailor-made by polymerase chain response (PCR), most of the ...
https://www.aprofarm.org/category/aa-214/page/3/
Keith Van Haren, MDs Profile | Stanford ProfilesKeith Van Haren, MD's Profile | Stanford Profiles
... and alpha-B-crystallin. In contrast, MS was characterized by IgM autoantibodies targeting myelin basic protein, proteolipid ... We performed a combination of tests: (i) a test for very-long-chain fatty acids (VLCFA) levels, (ii) a D3-C22:0 loading test to ... The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin ... saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have ...
https://profiles.stanford.edu/keith-vanharen?tab=bio
SCOP 1.71: Domain d1u15a : 1u15 ASCOP 1.71: Domain d1u15a : 1u15 A
d1u15a_ a.127.1.1 (A:) Argininosuccinate lyase/delta-crystallin {Domestic duck (Anas platyrhynchos), delta-crystallin} ... Class a: All alpha proteins [46456] (226 folds). *. Fold a.127: L-aspartase-like [48556] (1 superfamily). multihelical, ... Domains from other chains:. (mouse over for more information). d1u15b_, d1u15c_, d1u15d_ ... Protein Argininosuccinate lyase/delta-crystallin [48564] (4 species). *. Species Domestic duck (Anas platyrhynchos), delta- ...
http://scop.berkeley.edu/sunid=112948&ver=1.71
尋找研究成果 - 臺北醫學大學
Cloning of a putative chicken MHC class II alpha chain gene.. Kivela, J., Kung, H. J., Dodgson, J. & Bacon, L., 1月 1 1987, 於: ... Cloning and sequencing of a carp βs-crystallin cDNA. Chang, T. & Chang, W. C., 10月 9 1987, 於: BBA - Gene Structure and ... Extracellular thermostable alpha-amylase from Bacillus stearothermophilus Q8. Lin, H. Y. & Tsay, S. S., 1月 1 1987, 於: Zhonghua ...
https://tmu.pure.elsevier.com/zh/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Findustry_innovation_and_infrastructure&format=&ordering=publicationYearThenTitle&descending=true&page=886
Domain IPR003439:ABC transporter-likeDomain IPR003439:ABC transporter-like
Alpha-D-phosphohexomutase, alpha/beta/alpha domain II 76 Domain IPR002068:Alpha crystallin/Hsp20 domain 75 Domain IPR001030: ... alpha chain 2 Domain IPR025959:Winged helix-turn helix domain 2 Family IPR022053:Protein of unknown function DUF3613 2 Domain ... alpha/beta subunit, N-terminal domain 81 Domain IPR001623:DnaJ domain 81 Domain IPR005846:Alpha-D-phosphohexomutase, alpha/beta ... Alpha-D-phosphohexomutase, alpha/beta/alpha domain I 74 Domain IPR008333:Oxidoreductase, FAD-binding domain 74 Domain IPR000064 ...
https://www.cbrc.kaust.edu.sa/aamg/1502720332816_CamiLowProdigalV2_40.0_intikhab/WWWAAMG/visuals/CamiLowProdigalV2_AAMG_DOMAINS_data_summary.txt
GSE360 DC VS MAC L MAJOR UPGSE360 DC VS MAC L MAJOR UP
crystallin alpha A [Source:HGNC Sym.... CSF1R. 1436. CSF1R. colony stimulating factor 1 recepto.... ... dynein axonemal heavy chain 17 [Sou.... DNPEP. 23549. DNPEP. aspartyl aminopeptidase [Source:HGN.... ...
https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE360_DC_VS_MAC_L_MAJOR_UP.html
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
https://www.medscape.com/answers/1953022-186640/what-is-the-role-of-urinary-biomarkers-in-bladder-cancer-surveillance
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
http://emedicine.medscape.com/article/1953022-overview
DeCS 2018 - July 31, 2018 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2018.bvsalud.org/I/DeCS2018_Alfab-B.htm
DeCS 2017 - July 04, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2017.bvsalud.org/I/DeCS2017_Alfab-B.htm
DeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2019.bvsalud.org/I/DeCS2016_Alfab-B.htm
DeCS 2017 - December 21, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2020.bvsalud.org/I/DeCS2017_Alfab-B.htm
IMP: Integrative Multi-species Prediction
crystallin, alpha A. 0.016. Olfr159. olfactory receptor 159. 0.016. Myh8. myosin, heavy polypeptide 8, skeletal muscle, ... hemoglobin Y, beta-like embryonic chain. 0.014. Rbp3. retinol binding protein 3, interstitial. 0.014. ... mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative). 0.010. ... serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10. 0.014. ...
http://imp.princeton.edu/predictions/process/mouse-context-global/8070/?gene=88781
SubunitProteinsCRYABSubunitsCRYAAGeneLensProteinAntibodyMRNAChromosomeDyneinHumanTroponinAttached to the coTissuesMouseLightLensELISA KitGlycoproteinMammalianNeurological diseasesAntibodyGammaSubunit alphaRecombinantPutativeSequenceAntigensGene ExpressionZetaCollagen typeAntibodiesDomainMutantSymbol20kDaBreastStructuralBetaMeshPeptideNuclearDescriptionMajorSpecificAcidActivityStructure
Subunit1
  • SLBB domain, 4Fe-4S dicluster domain, RnfC Barrel sandwich hybrid domain, Respiratory-chain NADH dehydrogenase 51 Kd subunit [Interproscan]. (ntu.edu.sg)
Proteins4
  • However, fast skeletal myosin light chain 2 followed by troponin T, F-actin-capping and small heat shock proteins showed the greatest phosphorylation change, and therefore they were the most important phosphoproteins underlying LT muscle conversion to DFD meat in the Rubia Gallega breed. (biomedcentral.com)
  • A total of 21 proteins were successfully identified by MALDI-TOF-MS analysis, among which some interesting proteins, such as alpha B-crystallin, annexin A2, and stathmin 1, had been reported to involve in cell proliferation and differentiation through different signaling pathways. (big.ac.cn)
  • Utilizing a betasheet of the human ubiquitin for paratope creation we obtained binding proteins against tumor necrosis factor (TNF)-alpha. (navigo-proteins.com)
  • The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. (cipsm.de)
CRYAB1
  • To recombine the human alpha B-crystallin (αB-crystallin) utilizing gene cloning expertise and prokaryotic expression vector and ensure the organic exercise of recombinant human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, setting up the pET-28/CRYAB prokaryotic expression plasmid by restriction enzyme digestion technique, and stably expressing remodeled into the Escherichia coli (E. coli) DH5 alpha. (aprofarm.org)
Subunits3
  • Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (expasy.org)
  • One of the alpha crystallin subunits. (bvsalud.org)
  • the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. (prospecbio.com)
CRYAA1
Gene2
  • 8] Moreover, an analysis of antigen receptor H chain gene transcripts of B and plasma cells isolated from s-IBM muscle showed evidence of clonal expansion and variation, isotype switching, and somatic hypermutation, indicative of a local antigen-driven humoral response. (medscape.com)
  • A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. (musclegenetable.fr)
Lens1
  • The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. (nih.gov)
Protein2
  • Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. (elsevier.com)
  • Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). (prospecbio.com)
Antibody1
  • Various concepts for new formats combining antibody chains or antibody fragments and fusions with other entities have been developed recently. (navigo-proteins.com)
MRNA1
  • Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA. (genecopoeia.com)
Chromosome1
  • A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12. (musclegenetable.fr)
Dynein1
Human2
  • Recombination and identification of human alpha B-crystallin. (aprofarm.org)
  • Accumulation of amyloid in breast cancer is a well-known phenomenon, but only immunoglobulin light-chain amyloidosis (AL) or transthyretin (TTR) amyloid had been detected in human breast tumor samples previously. (inyushinlab.org)
Troponin1
  • Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. (musclegenetable.fr)
Attached to the co1
  • These dyes differ in the number of polyethylene glycol (PEG) chains attached to the core structure which is either a perylene derivate or a terrylene derivate. (cipsm.de)
Tissues2
  • Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. (prospecbio.com)
  • The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin and blood. (stanford.edu)
Mouse2
  • Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. (glembotskilab.org)
  • Mouse IgG2b heavy chains and κ light chain. (prospecbio.com)
Light3
  • Hydrocarbon chain order also correlated with light scattering intensity by sphingomyelin LUVs. (nih.gov)
  • Light scattered by LUVs composed of sphingomyelin (1-30 mg ml(-1)) was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. (nih.gov)
  • Increased lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid compositional changes can influence membrane light scattering properties. (nih.gov)
Lens8
  • Genes associated with the development of lens include crystallin genes. (nih.gov)
  • From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. (nih.gov)
  • alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. (nih.gov)
  • The extent of normal lens lipid hydrocarbon chain order increased with age from the equatorial and cortical regions to the nucleus. (arvojournals.org)
  • Increased lipid oxidation and hydrocarbon chain disorder correlate with increased lens nuclear opacity in the in vivo HBO model. (arvojournals.org)
  • Since it has been shown that lens injury may promote nerve regeneration, crystallin has been an area of neural research. (absoluteastronomy.com)
  • It is becoming increasingly clear that crystallins may have several metabolic and regulatory functions, both within the lens and in other parts of the body. (absoluteastronomy.com)
  • Yamada T、Tsuchida S. The Hirosaki small-eye rat: A novel recessive model animal of lens and retinal degeneration with loss of A3/A1-crystallin. (nichiyaku.ac.jp)
ELISA Kit2
  • Description: A sandwich ELISA kit for detection of Fibrinogen Alpha from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • Should the Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (wildpalm.net)
Glycoprotein1
  • We have examined the cleavage of ribonuclease A and the related N-linked glycoprotein ribonuclease B, and the O-linked glycoprotein alpha crystallin A chain, using MALDI-TOF and LC-ESI-MS to identify the peptide products. (researchgate.net)
Mammalian1
  • In addition, fish γM-crystallins do not conserve the paired tryptophan residues found in each domain in mammalian γ-crystallins and in the related β-crystallins. (nih.gov)
Neurological diseases1
  • Crystallins are divided into B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy. (neobiotechnologies.com)
Antibody5
  • Formalin-fixed, paraffin-embedded human Breast stained with Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • Western Blot Analysis of HeLa cell lysate using Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • SDS-PAGE Analysis Purified Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibrinogen Alpha (FGa) in Plasma. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fibrinogen Alpha (FGa) in samples from Plasma with no significant corss-reactivity with analogues from other species. (scalegen.com)
Gamma3
  • Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (uams.edu)
  • crystallin beta-gamma domain containi. (gsea-msigdb.org)
  • Alpha, beta, and gamma tubulins have all been used as loading controls. (neobiolab.com)
Subunit alpha1
  • Description: A competitive ELISA for quantitative measurement of Human Voltage dependent N type calcium channel subunit Alpha 1B(CACNA1B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (wildpalm.net)
Recombinant10
  • IFI30 Human Recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids (58-232) and having a molecular mass of 22.5 kDa. (neobiolab.com)
  • IFNA1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids (24-189) and having a molecular mass of 19.5 kDa. (neobiolab.com)
  • Interferon-alpha 1a Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19.4 kDa.The Interferon-alpha 1a contains Valine residue at position 114.The IFN-a 1a is purified by proprietary chromatographic techniques. (neobiolab.com)
  • Interferon-a 2b Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19269 Dalton. (neobiolab.com)
  • Interferon-beta 1a Human Recombinant produced in CHO (Chinese Hamster Ovarian) cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton.IFN-beta1a is purified by proprietary chromatographic techniques. (neobiolab.com)
  • Interferon beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human Interferon beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. (neobiolab.com)
  • Description: TDG Human Recombinant produced in E. coli is a single polypeptide chain containing 433 amino acids (1-410) and having a molecular mass of 48.4 kDa. (gentaur.se)
  • BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.BMP-5 is purified by proprietary chromatographic techniques. (kendallscientific.com)
  • BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, Polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. (kendallscientific.com)
  • BMPR1A Human Recombinant produced in HEK-293 cells is a single, glycosylated, polypeptide chain containing 369 amino acids with a molecular weight of43.7 kDa thoµgh on SDS-PAGE migrates at about 50 kDa due to the glycosilation.The BMPR1A is purified by proprietary chromatographic techniques. (kendallscientific.com)
Putative1
  • Cloning of a putative chicken MHC class II alpha chain gene. (elsevier.com)
Sequence1
  • The DNA sequence encoding the human BMP-2 signal peptide and propeptide (1~282 amino acid) fused to the human rhBMP-7 mature chain (293~431 amino acid) was expressed in a Chinese hamster ovary cell line. (kendallscientific.com)
Antigens2
  • Specifically, this diagnostic approach exploits M. tuberculosis secreted latency specific antigens, such as alpha-crystallin, in the blood or urine of patients. (nih.gov)
  • These antigens have a heavy chain and an associated light chain. (medscape.com)
Gene Expression1
  • Gene expression changes induced by short-term tumor necrosis factor-alpha (TNF-α) treatment were largely sustained in the FLS exposed to chronic inflammation. (surfaceyourrealself.com)
Zeta1
Collagen type3
Antibodies1
  • we performed immunohistochemistry on sectioned Myf-5 and MyoD mutant embryos with antibodies reactive with desmin , nestin, myosin heavy chain, sarcomeric actin, Myf-5, MyoD and myogenin. (labome.org)
Domain1
  • C.A. Barnes, Y. Shen, J. Ying, and A. Bax: Modulating the Stiffness of the Myosin VI Single alpha-Helical Domain. (nih.gov)
Mutant1
  • Mutant (P182L) but not wild-type HSPB1 led to the formation of insoluble intracellular aggregates and to the sequestration in the cytoplasm of selective cellular components, including neurofilament middle chain subunit (NF-M) and p150 dynactin. (lookformedical.com)
Symbol1
20kDa1
  • The Pegylated IFN-a 2b is produced by attaching a 20kDa mPEG-aldehyde to the N-terminal IFN alpha-2b. (neobiolab.com)
Breast2
  • 10. Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR. (nih.gov)
  • 18. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. (nih.gov)
Structural2
  • An alpha and beta tubulin heterodimer is the basic structural unit of microtubules. (neobiolab.com)
  • S.C. Chiliveri, J.M. Louis, and A. Bax: Concentration-dependent structural transition of the HIV-1 gp41 MPER peptide into alpha-helical trimers. (nih.gov)
Beta2
  • The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. (neobiolab.com)
  • TCR beta-chain does not appear to interact directly with beta2M. (cusabio.com)
Mesh1
  • Crystallins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Peptide1
  • A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of. (absoluteastronomy.com)
Nuclear1
Description3
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibrinogen Alpha (FGa) in samples from plasma. (scalegen.com)
  • Description: A competitive ELISA for quantitative measurement of Mouse fibrinogen alpha chain(FGA) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) in samples from tissue homogenates, cell lysates or other biological fluids. (wildpalm.net)
Major1
  • This graph shows the total number of publications written about "Crystallins" by people in UAMS Profiles by year, and whether "Crystallins" was a major or minor topic of these publications. (uams.edu)
Specific1
  • A specific phosphorylation regulates the protective role of αA-crystallin in diabetes. (vanderbilt.edu)
Acid2
  • The linkage of the glycosidic group to the asparagine side-chain in ribonuclease B was found not to be cleaved by brief microwave treatment in 12.5 % acetic acid. (researchgate.net)
  • The distribution of the heterogeneous carbohydrate side chain in the glycopeptide products of acid cleavage was compared to that of the glycopeptide products of tryptic digestion. (researchgate.net)
Activity1
  • Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (nih.gov)
Structure1
  • Solution Structure of the alpha-crystallin do. (nih.gov)
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio (lsbio.com)
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1 (genscript.com)
Lens proteins | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Lens proteins | Leaders in Pharmaceutical Business Intelligence (LPBI) Group (pharmaceuticalintelligence.com)
Shop - dianova
Shop - dianova (dianova.com)
Aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica
Aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica (aprofarm.org)
Keith Van Haren, MD's Profile | Stanford Profiles
Keith Van Haren, MD's Profile | Stanford Profiles (profiles.stanford.edu)
SCOP 1.71: Domain d1u15a_: 1u15 A
SCOP 1.71: Domain d1u15a_: 1u15 A (scop.berkeley.edu)
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,... (medscape.com)
SCOPe 2.08: Structural Classification of Proteins - extended
SCOPe 2.08: Structural Classification of Proteins - extended (scop.berkeley.edu)
SCOPe 2.07: Domain d1u16a_: 1u16 A
SCOPe 2.07: Domain d1u16a_: 1u16 A (scop.berkeley.edu)
The first evidence of global meat phosphoproteome changes in response to pre-slaughter stress | BMC Genomics | Full Text
The first evidence of global meat phosphoproteome changes in response to pre-slaughter stress | BMC Genomics | Full Text (bmcgenomics.biomedcentral.com)
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Eisenberg, David S.<...
Eisenberg, David S.<... (chemistry.ucla.edu)
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) | BMC Biology |...
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) | BMC Biology |... (bmcbiol.biomedcentral.com)
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations | Science...
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations | Science... (science.org)
Congenital Myopathies Treatment & Management: Approach Considerations, Medical Care, Surgical Care
Congenital Myopathies Treatment & Management: Approach Considerations, Medical Care, Surgical Care (medscape.com)
Inyushin Lab - UCC, School of Medicine
Inyushin Lab - UCC, School of Medicine (inyushinlab.org)
Douglas Vollrath's Profile | Stanford Profiles
Douglas Vollrath's Profile | Stanford Profiles (profiles.stanford.edu)
ISMARA results: EMX1
ISMARA results: EMX1 (ismara.unibas.ch)
MeSH Browser
MeSH Browser (meshb.nlm.nih.gov)