Progesterone Congeners: Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.Crystallins: A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.alpha-Crystallins: A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.Lens, Crystalline: A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.beta-Crystallin B Chain: The basic subunit of beta-crystallins.beta-Crystallin A Chain: The acidic subunit of beta-crystallins.gamma-Crystallins: A subclass of crystallins that found in the lens (LENS, CRYSTALLINE) of VERTEBRATES. Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. They are composed of monomeric subunits.beta-Crystallins: A class of crystallins that provides refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits.Ricin: A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.alpha-Crystallin A Chain: One of the subunits of alpha-crystallins. Unlike ALPHA-CRYSTALLIN B CHAIN the expression of ALPHA-CRYSTALLIN A CHAIN is limited primarily to the lens (LENS, CRYSTALLINE).alpha-Crystallin B Chain: One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.delta-Crystallins: A subclass of crystallins found in the lens (LENS, CRYSTALLINE) in BIRDS and REPTILES. They are inactive forms of the enzyme argininosuccinate lyase.Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Abrin: A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.Bungarus: A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. They comprise the kraits. Twelve species are recognized and all inhabit southeast Asia. They are considered extremely dangerous. (Moore: Poisonous Snakes of the World, 1980, p120)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.

Alterations in the mouse and human proteome caused by Huntington's disease. (1/314)

Huntington's disease is an autosomal dominantly inherited disease that usually starts in midlife and inevitably leads to death. In our effort to identify proteins involved in processes upstream or downstream of the disease-causing huntingtin, we studied the proteome of a well established mouse model by large gel two-dimensional electrophoresis. We could demonstrate for the first time at the protein level that alpha1-antitrypsin and alphaB-crystalline both decrease in expression over the course of disease. Importantly, the alpha1-antitrypsin decrease in the brain precedes that in liver and testes in mice. Reduced expression of the serine protease inhibitors alpha1-antitrypsin and contraspin was found in liver, heart, and testes close to terminal disease. Decreased expression of the chaperone alphaB-crystallin was found exclusively in the brain. In three brain regions obtained post-mortem from Huntington's disease patients, alpha1-antitrypsin expression was also altered. Reduced expression of the major urinary proteins not found in the brain was seen in the liver of affected mice, demonstrating that the disease exerts its influence outside the brain of transgenic mice at the protein level. Maintaining alpha1-antitrypsin and alphaB-crystallin availability during the course of Huntington's disease might prevent neuronal cell death and therefore could be useful in delaying the disease progression.  (+info)

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. (2/314)

Myoblasts respond to growth factor deprivation either by differentiating into multinucleated myotubes or by undergoing apoptosis; hence, the acquisition of apoptosis resistance by myogenic precursors is essential for their development. Here we demonstrate that the expression of the small heat shock protein alpha B-crystallin is selectively induced in C2C12 myoblasts that are resistant to differentiation-induced apoptosis, and we show that this induction occurs at an early stage in their differentiation in vitro. In contrast, the expression of several known anti-apoptotic proteins (FLIP, XIAP, Bcl-x(L)) was not altered during myogenesis. We also demonstrate that ectopic expression of alpha B-crystallin, but not the closely related small heat shock protein Hsp27, renders C2C12 myoblasts resistant to differentiation-induced apoptosis. Furthermore, we show that the myopathy-causing R120G alpha B-crystallin mutant is partly impaired in its cytoprotective function, whereas a pseudophosphorylation alpha B-crystallin mutant that mimics stress-induced phosphorylation is completely devoid of anti-apoptotic activity. Finally, we demonstrate that alpha B-crystallin negatively regulates apoptosis during myogenesis by inhibiting the proteolytic activation of caspase-3, whereas the R120G and pseudophosphorylation mutants are defective in this function. Taken together, our findings indicate that alpha B-crystallin is a novel negative regulator of myogenic apoptosis that directly links the differentiation program to apoptosis resistance.  (+info)

Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genes. (3/314)

The mouse Shsp/alphaB-crystallin and Mkbp/HspB2 genes are closely linked and divergently transcribed. In this study, we have analyzed the contribution of the intergenic enhancer to Shsp/alphaB-crystallin and Mkbp/HspB2 promoter activity using dual-reporter vectors in transient transfection and transgenic mouse experiments. Deletion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 30- and 93-fold and Mkbp/HspB2 promoter activity by 6- and 10-fold in transiently transfected mouse lens alpha-TN4 and myoblast C2C12 cells, respectively. Surprisingly, inversion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 17-fold, but did not affect Mkbp/HspB2 promoter activity in the transfected cells. In contrast, enhancer activity was orientation-independent in combination with a heterologous promoter in transfected cells. Transgenic mouse experiments established the orientation dependence and Shsp/alphaB-crystallin promoter preference of the intergenic enhancer in its native context. The orientation dependence and preferential effect of the Shsp/alphaB-crystallin enhancer on the Shsp/alphaB-crystallin promoter provide an example of adaptive changes in gene regulation accompanying the functional diversification of duplicated genes during evolution.  (+info)

Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. (4/314)

PURPOSE: The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the expression of the small heat shock protein alphaB-crystallin in the RPE in response to oxidative stress and to explore whether alphaB-crystallin expression confers an antiapoptotic cytoprotective effect on RPE cells. METHODS: Native human RPE cells from the macula and retinal periphery were analyzed by RT-PCR and Western blot analysis for expression of alphaB-crystallin. Monolayer cultures of human RPE cells were stressed by heat shock (42 degrees C for 20 minutes) or oxidant-mediated injury (50-300 micro M H(2)O(2) for 1 hour). Induction of alphaB-crystallin and the corresponding mRNA was assessed by Western and Northern blot analyses. To study the cytoprotective effect of alphaB-crystallin, human RPE cells were transfected with either a neomycin-selectable expression vector containing alphaB-crystallin cDNA or a control vector without alphaB-crystallin cDNA. Caspase-3 activity was determined by observing the cleavage of a colorimetric peptide substrate. Cell viability was quantified by combined propidium iodide and Hoechst 33342 staining. RESULTS: alphaB-crystallin is constitutively expressed in RPE under in vivo and in vitro conditions. Western blot analysis of freshly isolated RPE showed greater baseline expression levels in RPE derived from the macular area than in that from the more peripheral regions. Heat shock treatment and oxidative stress caused a significant increase in alphaB-crystallin mRNA and protein. Oxidant-mediated injury in RPE cells with baseline expression levels of alphaB-crystallin resulted in apoptotic cell death, as measured by caspase-3 activity, whereas RPE cells that had been stably transfected with alphaB-crystallin were more resistant to H(2)O(2)-induced cellular injury. CONCLUSIONS: alphaB-crystallin may function as a stress-inducible antiapoptotic protein in human RPE and is inducible by oxidative stress, a condition implicated in the pathogenesis of AMD. Overexpression of alphaB-crystallin may be an important mechanism for the RPE to prevent apoptotic cell death in response to cellular stress.  (+info)

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination. (5/314)

AlphaB-crystallin is a small heat-shock protein in which three serine residues (positions 19, 45, and 59) can be phosphorylated under various conditions. We describe here the interaction of alphaB-crystallin with FBX4, an F-box-containing protein that is a component of the ubiquitin-protein isopeptide ligase SCF (SKP1/CUL1/F-box). The interaction with FBX4 was enhanced by mimicking phosphorylation of alphaB-crystallin at both Ser-19 and Ser-45 (S19D/S45D), but not at other combinations. Ser-19 and Ser-45 are preferentially phosphorylated during the mitotic phase of the cell cycle. Also alphaB-crystallin R120G, a mutant found to co-segregate with a desmin-related myopathy, displayed increased interaction with FBX4. Both alphaB-crystallin S19D/S45D and R120G specifically translocated FBX4 to the detergent-insoluble fraction and stimulated the ubiquitination of one or a few yet unknown proteins. These findings implicate the involvement of alphaB-crystallin in the ubiquitin/proteasome pathway in a phosphorylation- and cell cycle-dependent manner and may provide new insights into the alphaB-crystallin-induced aggregation in desmin-related myopathy.  (+info)

Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of two-mode binding in alphaB-crystallin. (6/314)

The consequences of alphaB-crystallin phosphorylation on its chaperone activity were investigated using a detailed analysis of the recognition and binding of destabilized T4 lysozyme (T4L) mutants by alphaB-crystallin phosphorylation mimics containing combinations of serine to aspartate substitutions. The T4L site-directed mutants were selected to constitute an energetic ladder of progressively destabilized proteins having similar structures in the folded state. alphaB-crystallin and its variants differentially recognize the T4L mutants, binding the more destabilized ones to a larger extent. Furthermore, the aspartate substitutions result in an increase in the extent of binding to the same T4L mutant and in the appearance of biphasic binding isotherms. The latter indicates the presence of two modes of binding characterized by different affinities and different numbers of binding sites. The transition to two-mode binding can also be induced by temperature or pH activation of the second mode. The similarity between the phosphorylation, pH, and temperature effects suggests a common structural origin. The location of the phosphorylation sites in the N-terminal domain and the hypothesized burial of this domain in the core of the oligomeric structure are consistent with a critical role for the destabilization of the quaternary structure in the process of recognition and binding by small heat-shock proteins.  (+info)

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. (7/314)

BACKGROUND: One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO). METHODS: Lenses from 129SvEvTac mice and alpha A/BKO mice were examined by standard scanning electron microscopy and confocal microscopy methodologies. RESULTS: Equatorial and axial (sagittal) dimensions of lenses for alpha A/BKO mice were significantly smaller than age-matched wild type lenses. No posterior sutures or fiber cells extending to the posterior capsule of the lens were found in alpha A/BKO lenses. Ectopical nucleic acid staining was observed in the posterior subcapsular region of 5 wk and anterior subcapsular cortex of 54 wk alpha A/BKO lenses. Gross morphological differences were also observed in the equatorial/bow, posterior and anterior regions of lenses from alpha A/BKO mice as compared to wild mice. CONCLUSION: These results indicated that both alpha A- and alpha B-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation.  (+info)

Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. (8/314)

AlphaB-crystallin (alphaBC), a small heat shock protein expressed in high levels in the heart, is phosphorylated on Ser-19, 45, and 59 after stress. However, it is not known whether alphaBC phosphorylation directly affects cell survival. In the present study, constructs were prepared that encode forms of alphaBC harboring Ser to Ala (blocks phosphorylation) or Ser to Glu (mimics phosphorylation) mutations at positions 19, 45, and 59. The effects of each form on apoptosis of cultured cardiac myocytes after hyperosmotic or hypoxic stress were assessed. Compared with controls, cells that expressed alphaBC with Ser to Ala substitutions at all three positions, alphaBC(AAA), exhibited more stress-induced apoptosis. Cells expressing either alphaBC(AAE) or (EEE) exhibited 3-fold less apoptosis than cells expressing alphaBC(AAA), indicating that phosphorylation of Ser-59 confers protection. alphaBC is known to bind to procaspase-3 and to decrease caspase-3 activation. Compared with cells expressing alphaBC(AAA), the activation of caspase-3 was decreased by 3-fold in cells expressing alphaBC(AAE). These results demonstrate that mimicking the phosphorylation of alphaBC on Ser-59 is necessary and sufficient to confer caspase-3 inhibition and protection of cardiac myocytes against hyperosmotic or hypoxic stress. These findings provide direct evidence that alphaBC(S59P) contributes to the cardioprotection observed after physiologically relevant stresses, such as transient hypoxia. Identifying the targets of alphaBC(S59P) will reveal important details about the mechanism underlying the cytoprotective effects of this small heat shock protein.  (+info)

*CRYAB

... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Alpha B chain crystallins (αBC) can be induced by heat shock, ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. These ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein ...

*CRYAA

Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Crystallins are separated into two classes: ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an ...

*List of MeSH codes (D12.776)

... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate dehydrogenase MeSH D12.776.377.715.085.050 - alpha 1- ... immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - immunoglobulin alpha-chains MeSH D12.776.377.715.548.705. ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...

*CRYBB2

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as ... "Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2 ... Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four ... Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene. Crystallins are separated into two classes: taxon ...

*Chromosome 1 (human)

... heavy chain 14 ECM1 (1q21) EDEM3: ER degradation enhancing alpha-mannosidase like protein 3 EGLN1 (1q42) ENAH (1q42) ESRRG ( ... Crystallin zeta CYP4B1 (1p33) CYR61 (1p22) DBT: dihydrolipoamide branched chain transacylase E2 DCLRE1B: DNA cross-link repair ... 2-alpha-mannosidase IB MEAF6: MYST/ESA1 associated factor 6 MECR: Trans-2-enoyl-CoA reductase, mitochondrial MFAP2: ... C-4 to C-12 straight chain ACTL8: Actin-like 8 ADGRL2 (1p31.1): adhesion G protein-coupled receptor L2 ADPRHL2: Poly(ADP-ribose ...

*Aldo-keto reductase

... rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide ... Some proteins of this family contain a potassium channel beta chain regulatory domain; these are reported to have ... The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in ...

*List of A1 genes, proteins or receptors

... alpha 1 Collagen, type XIX, alpha 1 Collagen, type XXV, alpha 1 Collagen, type XXVII, alpha 1 Crystallin, beta A1 Cyclic ... DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein NADH ... alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ...

*Perlecan

The N-terminal domain I (aa ~1-195) contains attachment sites for HS chains. Although HS chains are not required for correct ... To this end, a transgenic mouse line was created expressing porcine TGF-β1 under the lens-specific αA-crystallin promoter and ... In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain ... The heparan sulfate chains of perlecan bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound ...

*OGT (gene)

"Vertebrate lens alpha-crystallins are modified by O-linked N-acetylglucosamine". The Journal of Biological Chemistry. 267 (1): ... and a peptide chain with a reactive serine or threonine hydroxyl group. The proposed reaction is an ordered sequential bi-bi ... "Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin". Biochemistry. 35 (11): 3578-86. doi:10.1021/ ...

*Argininosuccinate lyase

Domain 2 contains one small beta sheet, nine alpha helices, and the carboxyl terminus. Three of the nine alpha helices on one ... δ-crystallins are the major structural eye lens water-soluble proteins of most birds, reptiles, and some other vertebrates. ... ASL is composed of four identical monomers; each monomer consisting of a single polypeptide chain between 49 and 52 kDa, ... Two dimers then associate by way of alpha helix, one from each monomer, to form a central 20-helix core. The association of all ...

*Protease inhibitor (biology)

The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... is a double-chain inhibitor consisting of an 11-residue and a 41-residue chain. The Carboxypeptidase inhibitor I68 family ... The yeast killer toxin structure was thought to be a precursor of the two-domain beta gamma-crystallin proteins, because of its ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ...

*Sean M. Decatur

Silva, R.A.G.D., *Nguyen, J.Y., and Decatur, S.M. (2002) "Probing the Effects of Side Chains on the Conformation and Stability ... "Formation of Amyloid Fibrils in Vitro by Human γd-crystallin and its Isolated Domains," Molecular Vision 14:81-89. Decatur, S.M ... "Two dimensional infrared measurements of the coupling of the amide modes of an alpha helix," Chemical Physics Letters 382: 586- ... "Twodimensional IR Spectroscopy and Segmental 13C Labeling reveals the Domain Structure of Human γδ-crystallin amyloid fibrils ...

*Glucosepane

These compounds are thought to act as bidentate nucleophiles that attack the adjacent carbonyls in the alpha-dicarbonyl ... and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane ... This then condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the ... such as collagen in the skin and crystallin in the eyes. Skin collagen, for instance, has a half-life of fifteen years. Because ...

*List of distinct cell types in the adult human body

Alpha cells (secreting glucagon) Beta cells (secreting insulin and amylin) Delta cells (secreting somatostatin) PP cells (gamma ... Intermediate skeletal muscle cell Nuclear bag cell of muscle spindle Nuclear chain cell of muscle spindle Satellite cell (stem ... Anterior lens epithelial cell Crystallin-containing lens fiber cell Adipocytes: White fat cell Brown fat cell Liver lipocyte ...

*List of MeSH codes (D08)

... cholesterol side-chain cleavage enzyme MeSH D08.811.682.690.708.170.915.400 --- 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH ... delta-crystallins MeSH D08.811.520.232.400 --- ammonia-lyases MeSH D08.811.520.232.400.200 --- aspartate ammonia-lyase MeSH ... cholesterol side-chain cleavage enzyme MeSH D08.244.453.915.400 --- 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.244. ... cholesterol side-chain cleavage enzyme MeSH D08.811.682.690.708.783.400 --- 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH ...

*Transketolase

... and aspartate side-chains, with a glutamate side-chain playing a secondary role. These side-chains, to be specific Arg359, ... and Asp477 forms hydrogen bonds with the alpha hydroxyl group on the substrate, where it works to effectively bind the ... in the mammalian cornea by the stromal keratocytes and epithelial cells and is reputed to be one of the corneal crystallins. ... To be specific, the His 263 and His30 side-chains form hydrogen bonds to the aldehyde end of the substrate, which is deepest ...

*Amyloid beta

"Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the ... Oligomerization is a chemical process that converts individual molecules into a chain consisting of a finite number of ... Intra-cellular deposits of tau protein are also seen in the disease, and may also be implicated, as has aggregation of alpha ... leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in ...
Myofibrillar myopathy (MFM) is a non-committal term for a pathological pattern of myofibrillar dissolution associated with accumulation of myofibrillar degradation products and ectopic expression of multiple proteins that include desmin, alphaB-crystallin (alphaBC), dystrophin and (...). ...
Giving mice a naturally occurring protein called alpha-B-crystallin that is made in the body, shrank brain lesions caused by stroke, even when treated 12 hours after the event, according to...
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... , Authors: Aysegul Ilhan, Ludwig Wagner, Wolfgang Gartner. Published in: Atlas Genet Cytogenet Oncol Haematol.
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Desmin-related myopathy is a subgroup of myofibrillar myopathy caused by mutations in desmin, CryAB, and other proteins that interact with the intermediate filaments. The pathology is characterized by myofibril disruption that appears to initiate at the Z-disk. Dislocation and aggregation of membranous organelles is observed as well as the accumulation of the mutant, misfolded desmin, and/or CryAB into insoluble aggregates, which gradually increase in the cytoplasm and are thought to eventually result in cell death.1-3 We previously showed that these aggregates may be classified as aggresomes, whose accumulation is often associated with neurodegenerative diseases caused by protein misfolding or unfolding.8 Our studies showed that the aggresomes present in the cardiomyocytes contain large concentrations of a toxic amyloid oligomer, which is typically found in many of the amyloid-based neurodegenerative diseases. The data thus link these cardiomyopathies to a broad class of amyloid-based ...
Desmin-related cardiomyopathy (DRC) belongs to the family of myofibrillar diseases characterized by the presence of toxic desmin-positive aggregates and degeneration at Z-disk structures. DRC has been linked to the mutations in the desmin, αBcrystallin (CryAB), or myotilin genes. Several human CryAB mutations cause multisystem disorders and experimental models of R120GCryAB in transgenic mice strikingly recapitulate similar phenotype observed in patients. In this context, we have generated the 450delACryAB linked to inheritable cataracts in neonatal rat cardiomyocytes and mice hearts. 450delACryAB formed aggregates or aggresomes, and recruited HSP25 into the insoluble fraction in the cardiomyocytes. However, heart-specific 450delA CryAB overexpression neither causes desmin-related cardiomyopathy nor exacerbates pressure overload-induced hypertrophy. To our knowledge, this is the first report of compensation to protein aggregates formation abrogates the development of cardiomyopathy and suggests ...
Accordingly, its important to look beyond the ostensibly obvious results like "low AGE diets promote fat and weight loss". While this may be true, even the cursory analysis of the study results in todays SuppVersity short news indicates that the obvious conclusion that reducing AGEs would mechanistically reduce body fat is probably flawed. Rather than that people who avoid high AGE foods will necessary avoid foods with high energy density, consume less energy and lose weight in response to a reduction in energy intake - not in response to the reduced intake of AGEs. Problems like these are why it is important to look beyond the conclusions in the abstracts and / or come back to the SuppVersity regularly for short and in-depth analyses of the latest studies , Comment on Facebook ...
Jeffrey Rosenthal - Jeffrey Rosenthal earned his PhD in mathematics from Harvard at just 24 years old. From there, he became a professor in the department of statistic...
Sporadic and familial neuromuscular conditions marked by a surplus of proteins present in a granular or filamentous form, such as desmin-related (...)
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TY - JOUR. T1 - P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress. AU - Su, Huabo. AU - Wang, Xuejun. PY - 2011/11/1. Y1 - 2011/11/1. N2 - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.. AB - As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated ...
Title:In Vitro Holdase Activity of E. coli Small Heat-Shock Proteins IbpA, IbpB and IbpAB: A Biophysical Study with Some Unconventional Techniques. VOLUME: 21 ISSUE: 6. Author(s):Sourav Singha Roy, Monobesh Patra, Suman Kumar Nandy, Milon Banik, Rakhi Dasgupta and Tarakdas Basu. Affiliation:Department of Biochemistry and Biophysics, University of Kalyani, Kalyani - 741 235, West Bengal, India.. Keywords:Atomic force microscopy, dynamic light scattering, E. coli Small heat shock proteins IbpA & IbpB, holdase activity, lactate dehydrogenase, micro-viscometry.. Abstract:E. coli small heat shock proteins IbpA and IbpB (inclusion body binding proteins A and B) are known to act as holding chaperones on denaturing, aggregate-prone proteins. But, there is no clear understanding about which of the IbpA and IbpB has more holdase activity and how the holdase activity of one was influenced by the presence of the other. This study was conducted to resolve the questions, using some uncommon physical ...
Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Post-translational modifications decrease the ability to chaperone. Defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimers disease and Parkinsons disease. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the CNS. A key step in pathogenesis appears to be the accumulation of GFAP within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites: CSF and blood. We find that GFAP levels are consistently elevated in the CSF of patients with Alexander disease, but only occasionally and modestly elevated in blood. These results provide the
Alexander Disease on National Stem Cell Foundation | Alexander disease is a leukodystrophy, a group of more than 15 rare genetic disorders that cause…
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Alexander disease, a Leukodystrophy, is a progressive and fatal neurological disorder in which the destruction of white matter in the brain is accompanied by the formation of abnormal deposits known as Rosenthal fibers. Rosenthal fibers are aggregations of protein that occur in astrocytes, one of the so-called "glial" cells of the central nervous system. These aggregates are found occasionally in other disorders, but not with the abundance or particular distribution in the brain that occurs in Alexander disease.. The age of onset is quite variable, ranging from prenatal through the sixth decade. The most common classification divides patients into three categories based on age of onset, infantile (0-2 years), juvenile (2-12 years), and adult (,12 years). More recently, a different classification has been proposed, with only two categories of type I and type II, with the distinction hinging more on distribution of lesions and clinical presentation rather than age of onset (all type I cases being ...
J Pathol. 176(2):207-16. PubMed Abstract.. 2. Cassiman D, Roskams T, van Pelt J, Libbrecht L, Aertsen P, Crabbe T, Vankelecom H, Denef C. (2001) Alpha B-crystallin expression in human and rat hepatic stellate cells. J Hepatol. 35(2):200-7. PubMed Abstract.. 3. Ishiguro Y, Kato K, Akatsuka H, Iwata H, Nagaya M. (1997) Chemotherapy-induced expression of alpha B-crystallin in neuroblastoma. Med Pediatr Oncol. 29(1):11-5. PubMed Abstract.. 4. Iwaki T, Iwaki A, Liem RK, Goldman JE. (1991) Expression of alpha B-crystallin in the developing rat kidney. Kidney Int. 40(1):52-6. PubMed Abstract. 5. Iwaki T, Wisniewski T, Iwaki A, Corbin E, Tomokane N, Tateishi J, Goldman JE. (1992) Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions. Am J Pathol. 140(2):345-56. PubMed Abstract.. 6. Cooper PN, Jackson M, Lennox G, Lowe J, Mann DM. (1995) Tau, ubiquitin, and alpha B-crystallin immunohistochemistry define the principal causes of degenerative frontotemporal ...
A representation of NAD showing the change that occurs in the nicotinamide moiety (encircled) when NAD+ is reduced to NADH. In NAD+, the nicotinamide moiety has a planar structure, whereas it is puckered in NADH as shown in this animation (avi).. In facultative aerobic bacteria the catabolism of fuel molecules is associated with the reduction of NAD+ to NADH. During the transition to oxygen limited growth, an increased level of NADH builds up, as it is less efficiently reoxidized to NAD+ as a result of reduced aerobic respiration. These roles of NADH and NAD+ provide a link between energy homeostasis and gene regulation. In most Gram-positive bacteria a novel sensor of the NAD redox balance is present. This transcriptional repressor is called Rex (from redox; Figure 2). Transcription of Rex-repressed genes in Bacillus subtilis is activated when oxygen is limiting for aerobic respiration, and as a consequence the levels of free NADH increase. This leads to production of cytochrome bd (a ...
α-Crystallin is the principal lens protein which, in addition to its structural role, also acts as a molecular chaperone, to prevent aggregation and precipitation of other lens proteins. One of its two subunits, αB-crystallin, is also expressed in many non-lenticular tissues, and a natural missense mutation, R120G, has been associated with cataract and desminrelated myopathy, a disorder of skeletal muscles (Vicart et al., 1998, Nature Genet. 20:92-95). In the present study, real-time 1H NMR spectroscopy showed that the ability of R120G αB-crystallin to stabilize the partially folded, molten globule state of α- lactalbumin was significantly reduced in comparison with wild type αB-crystallin. The mutant showed enhanced interaction with, and promoted unfolding of reduced α- lactalbumin, while it showed limited chaperone activity for other target proteins. Using NMR spectroscopy, gel electrophoresis and mass spectrometry (MS) it was observed that, unlike the wild type protein, R120G αB-crystallin is
Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.: The autosomal dominant mutation in the human al
See the Rosenthal surname, family crest & coat of arms. Free Search. Uncover the Rosenthal surname history for the German Origin. What is the history of the last name Rosenthal?
ATGen operates in the Commercial Physical Research sector. ATGen is a Korea-based company principally engaged in developing and manufacturing reagent used for experimentation . The Companys product portfolio consists of recombination proteins including binding immunoglobulin protein, carboxy terminus of HSP70 interacting protein, BCL2-associated athanogene 2; monoclonal antibodies including 14-3-3 beta antibody, A crystallin A antibody , alpha-crystallin B and NK Vue Kit used for physical examination and diagnosis. The Company distributes its products within domestic market and to overseas markets.
The Rosenthal Malibu winery holds a variety of year-round Malibu wine tasting events. We offer special VIP access for members and a variety of wines online.
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A young Southern woman of modest means suddenly finds herself thrust into New Yorks high society when she discovers that she is the illegitimate daughter of...
Purpose: : In our previous studies, we have demonstrated that alpha-crystallins can negatively regulate stress-induced apoptosis through suppression of the ERK-mediated pathway and activation of the AKT signaling pathway. In the present study, we present evidence to show that alpha-crystallins can regulate the ATR-p53 pathway to prevent UVA-induced apoptosis. Methods: : UVA was used to irradiate human lens epithelial cells stably expressing vector, alphaA, and alphaB. Western blot analysis was used for detection of ATR, CHK1/2 and p53 activation. Reporter gene activity assay was used to explore the transactivity of p53. Hoechst staining was used for apoptosis assay. Results: : Human lens epithelial cells expressing either alphaA- or alphaB-crystallin are substantially resistant to UVA-induced apoptosis. UVA-induces activation of ATR and CHK1/2 kinases to activate p53 in vector-transfected cells. However, in alphaA- or alphaB-crystallin-transfected cells, activation of ATR, CHK1/2 kinases and p53 ...
Alexander disease, also known as fibrinoid leukodystrophy, is a progressive and fatal neurodegenerative disease. It is a rare genetic disorder and mostly affects infants and children, causing developmental delay and changes in physical characteristics. Delays in development of some physical, psychological and behavioral skills; progressive enlargement of the head (macrocephaly), seizures, spasticity, and in some cases also hydrocephalus, idiopathic intracranial hypertension, and dementia. Alexander disease is a genetic disorder affecting the midbrain and cerebellum of the central nervous system. It is caused by mutations in the gene for glial fibrillary acidic protein (GFAP) that maps to chromosome 17q21. It is inherited in an autosomal dominant manner, such that the child of a parent with the disease has a 50% chance of inheriting the condition, if the parent is heterozygotic. However, most cases arise de novo as the result of sporadic mutations. Alexander disease belongs to leukodystrophies, a ...
Mycobacterium tuberculosis (Mtb) forms biofilms harbouring antibiotic-tolerant bacilli in vitro, but the factors that induce biofilm formation and the nature of the extracellular material that holds the cells together are poorly understood. Here we show that intracellular thiol reductive stress (TRS) induces formation of Mtb biofilms in vitro, which harbour drug-tolerant but metabolically active bacteria with unchanged levels of ATP/ADP, NAD(+)/NADH and NADP(+)/NADPH. The development of these biofilms requires DNA, RNA and protein synthesis. Transcriptional analysis suggests that Mtb modulates only ∼7% of its genes for survival in biofilms. In addition to proteins, lipids and DNA, the extracellular material in these biofilms is primarily composed of polysaccharides, with cellulose being a key component. Our results contribute to a better understanding of the mechanisms underlying Mtb biofilm formation, although the clinical relevance of Mtb biofilms in human tuberculosis remains ...
Evolutionary variation for accumulation of small heat shock protein (sHsp) may contribute to thermal niche differentiation between species. Here we examine temperature and time-course-dependent variation for sHsp accumulation in a recently diverged pair of Encelia raised in a common environment: Encelia farinosa, common in the Mojave desert, and Encelia californica, which is found along the cool coastal bluffs of southern North America. Both species exhibit peak sHsp accumulation at 42oC. Encelia californica accumulated greater levels of sHsp at temperatures below 42oC, while E. farinosa had greater levels above 42oC. Encelia farinosa accumulates sHsp at temperatures up to 45oC, while E. californica does not synthesize sHsp above 44oC. Both species accumulated significant levels of sHsp while maintaining photosynthetic electron transport Fv/Fm, but above the temperatures that elicited peak sHsp expression, levels of sHsp and Fv/Fm declined in parallel to zero. Encelia californica accumulated greater
Health,...SALT LAKE CITY -- Antioxidants are widely considered an important defe...The findings published in the Aug. 10 issue of Cell indicate a new c...The protein alpha B-Crystallin termed a molecular chaperone normally...In a study of laboratory mice with failing hearts caused by mutant alp...,Reductive,stress,linked,to,heart,disease,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The eleven students involved learned basic experimental design (with positive and negative controls), troubleshooting, a wide variety of laboratory techniques, and data collection, analysis and presentations skills. In addition, students learned to read and analyze scientific work from other labs since they are given scientific articles to read beginning on their first day in the lab. This project is in collaboration with Ivor Benjamin M.D., Ph.D. at the University of Utah, which allowed these students the unique opportunity of discussing their research with a larger audience once a month. In addition to intellectual enrichment, students learned to function as a team, with those more experienced (graduate students Kelsey Langston and Whitney Hayes) mentoring those who are new in the lab. As students progressed in their understanding of the project and mastery of basic laboratory skills, they become involved in planning our weekly group meeting, preparing figures for presentations/publications, ...
JUPITER, Fla. -- Trevor Rosenthal stopped his live batting-practice session a few pitches early due to a right groin strain on Tuesday, but he said afterward that he does not expect the issue to sideline him for long. Rosenthal called trainer Greg Hauck and manager Mike Matheny over near the end of his throwing session to alert them to the discomfort. Rosenthal said he wanted to make the staff aware, because he had never before experienced tightness in that area.
View mouse Hspb11 Chr4:107253593-107279938 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Emed, A.; Rosenthal, Móricz.; Grünfeld, József.; Spitzer, Sándor., 2003: Hungarian physicians in Vienna: Móric Rosenthal, József Grünfeld, Sándor Spitzer
Helianthus annuus hsp17.6 G1 protein: a small heat-shock protein from sunflower; amino acid sequence in first source; GenBank Z95153
https://twitter.com/#!/CCSVI_Society Dr. Alexander (endothelial biologist) now presenting MS and cerebral endothelial dysfunctionDr. Alexander: endothelium becomes sticky with shear: activates leukocytes into brain parenchyma Dr. Alexander: endothelial cells very sensitive to glycemic (glucose) and oxidative stressDr. Alexander: Interferon beta may have ...
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Rosenthal, A S., "Determinant selection and macrophage function in genetic control of the immune response." (1978). Subject Strain Bibliography 1978. 3821 ...
Heat-stress induced alterations in localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for ?B-crystallin and hsp ...
Complete information for HSPA2 gene (Protein Coding), Heat Shock Protein Family A (Hsp70) Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
WHAT fellow art thou, who darest thus to lie at thy ease in our presence, when all others, as thou seest, rise to do us homage? dost thou not know us?. Diog. I cannot say I do: but by the number of thy attendants, by the splendour of thy habit; but, above all, by the vanity of thy appearance, and the arrogance of thy speech, I conceive thou mayst be Alexander the son of Philip.. Alex. And who can more justly challenge thy respect, than Alexander, at the head of that victorious army, who hath performed such wonderful exploits, [1] and, under his conduct, hath subdued the world?. Diog. Who? why the tailor who made me this old cloke.. Alex. Thou art an odd fellow, and I have a curiosity to know thy name.. Diog. I am not ashamed of it: I am called Diogenes: a name composed of as many and as well-sounding syllables as Alexander.. Alex. Diogenes, I rejoice at this encounter. I have heard of thy name, and been long desirous of seeing thee; in which wish, since fortune hath accidentally favoured me, I ...
Chen X, Lin S, Liu Q, Huang J, Zhang W, Lin J, Wang Y, Ke Y, He H. Expression and interaction of small heat shock proteins (sHsps) in rice in response to heat stress. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2014, 1844 (4): 818-828. ...
At file:///home/bar/mysql-bzr/mysql-trunk-wl946/ based on revid:[email protected] 3365 Alexander Barkov 2011-05-18 WL#946: fixing some test failures. As the datatype of @@timestamp has changed from Sys_var_session_special (ulonglong based) to Sys_var_session_special_double (double bases), its not any more correct to use "~(time_t)0" as the upper limit parameter to constructor. modified: sql/sys_vars.cc === modified file sql/sys_vars.cc --- a/sql/sys_vars.cc 2011-05-18 17:21:03 +0000 +++ b/sql/sys_vars.cc 2011-05-18 19:59:19 +0000 @@ -2730,7 +2730,7 @@ static bool check_timestamp(sys_var *sel static Sys_var_session_special_double Sys_timestamp( "timestamp", "Set the time for this client", sys_var::ONLY_SESSION, NO_CMD_LINE, - VALID_RANGE(0, ~(time_t)0), BLOCK_SIZE(1), + VALID_RANGE(0, TIMESTAMP_MAX_VALUE + 1), BLOCK_SIZE(1), NO_MUTEX_GUARD, IN_BINLOG, ON_CHECK(check_timestamp), ON_UPDATE(update_timestamp), ON_READ(read_timestamp)); Attachment: [text/bzr-bundle] ...
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Smenes, Benedikte Therese; Pettersen, Øystein; Stenseth, Roar; Karlsen, Øystein; Wahba, Alexander. (2017) Evaluering av phase of care mortality analysis og failure to rescue i en Norsk thoraxkirurgisk klinikk. Vitenskapelige forhandlinger / De norske kirurgiske foreninger. vol. 93. ...
Free and open person profile of Alexander Dick, who is Representative before the EPO of Herzog Fiesser & Partner Patentanwälte PartG mbB.
Ilena Rosenthal used Tim Bolens defamatory posts to target Terry Polevoy, MD for destruction. Its now in the hands of the California courts for final disposition.
Ilena Rosenthal used Tim Bolens defamatory posts to target Terry Polevoy, MD for destruction. Its now in the hands of the California courts for final disposition.
Demilly, D. et al. Liste alphabétique des principales espèces de plantes cultivées et de mauvaises herbes. Noms latins et noms français, ed. 7. 2001 (L Noms French ed7 ...
Zilinskas, J. and Costan, A. and Cascella, R. G. and Kecskemeti, G. and Emmanuel, J. and Cannataro, M. and Ricci, L. and Benkner, Siegfried and Petit, S. and Scarano, V. and Gracia, J. and Hunold, S. and Scott, S. L: and Lankes, S. and Lengauer, C. and Carretero, J. and Breitbart, J. and Alexander, M. ISSN 0302-9743 (2014) ...
The coordinated cellular responses to physiological stress are known to be effected in part by the activation of heat-shock factor 1, a transcriptional activator protein capable of binding to, and inducing transcription from genes containing heat shock elements. Other stress responsive signal transduction pathways also exist including the stress activated protein kinase cascade that regulates the activity of the transcription factor AP1. We have examined the expression of the low molecular stress proteins, heat shock protein 27 and alpha B-crystallin in astrocytes in response to physiological stress of different types and asked what component of this induction is effected at the transcriptional level and whether activation of heat shock factor 1 and AP1 might account for these events. We have found that stress regulated induction of alpha B-crystallin has a strong transcriptional component and that it may be effected by at least two different transcriptional mechanisms. In one set of phenomena, ...
The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular pathogenesis remains incompletely defined in HCC. Here we report that increased expression of αB-Crystallin in human HCC predicts poor survival and disease recurrence after surgery. Multivariate analysis identifies αB-Crystallin expression as an independent predictor for postoperative recurrence and overall survival. We show that elevated expression of αB-Crystallin promotes HCC progression in vivo and in vitro. We demonstrate that αB-Crystallin overexpression fosters HCC progression by inducing epithelial-mesenchymal transition (EMT) in HCC cells through activation of the extracellular-regulated protein kinase (ERK) cascade, which can counteract the effect of sorafenib. αB-Crystallin complexes with and elevates 14-3-3ζ protein, leading to up-regulation of ERK1/2 activity. Moreover, overexpression of αB-Crystallin in HCC cells induces EMT progression through an ERK1/2/Fra-1/slug signaling ...
Dr. Walter Rosenthal is the director of the Forschungsinstitut für Molekulare Pharmakologie in Berlin, Germany. His involvement in Nephrogenic Diabetes Insipidus began by chance in 1991 with a visit from an old friend, Dr. Lutz Birnbaumer. During their visit Dr. Birnbaumer mentioned that his wife, Dr. Mariel Birnbaumer was working to clone the human V2 receptor. Dr. Rosenthal was, at that time, studying mechanisms of transmembrane signalling. The possibility of cloning the V2 receptor was of great interest to him since he was planning to look at signal transduction defects underlying diseases. He was soon working with Dr. Birnbaumer on the cloning project. Shortly after the V2 receptor gene was successfully cloned, Dr. Rosenthal identified the first mutation in the V2 receptor associated with NDI. Visualization of the V2 receptor expressed in COS cells -laser confocal microscopy- Dr. Rosenthal feels that the ability to make early, positive diagnosis of NDI has been a great help in management of
As with other simple jerry rosenthal casino mentioned above the Paroli System relies on you placing outside even money bets on roulette. Although it works best on the bets that have a near fifty-fifty chance of winning or losing, it can be applied to any game of chance. Youve got to give them the key to everything thats yours. FlexPay is a free and easy way to divide your purchase into monthly payments with your debit or credit card. You tell the dealer how much each of your roulette chips will be jerry rosenthal casino, she indicates that amount on her wheel of chips, and then she parcels your chips out to you. Hi Ms Chievous. The exact odds offered and the minimum winning hand vary jerry rosenthal casino game to game. I hope Ill be able incorporate them in a novel Im working on, and I really hope yours gets published. They have both gained weight as they have grown, and they have now, as my hubby put it, broken the kilo barrier. In order for a VP machine to be profitable, however, it will ...
Cramer Rosenthal Mcglynn LLC lessened its stake in shares of CONMED Corporation (NASDAQ:CNMD) by 4.0% during the 3rd quarter, according to its most recent filing with the Securities and Exchange Commission. The institutional investor owned 1,025,284 shares of the medical technology companys stock after selling 42,560 shares during the quarter. Cramer Rosenthal Mcglynn LLC owned […]
Dave Rosenthal is CEO of N. Virginia-based, FoundationDB. He started programming by building games. In high school he formed a team of students that designed and built Fire and Darkness, a 3D strategy game that won the grand prize at the 1st Independent Games Festival. In 2001 he applied his interactive design skills to large-scale data processing as the first employee at Visual Sciences. Visual Sciences unique take on web analytics data analytics product defined the high end of web analytics. After Visual Sciences was acquired in 2006 he served as CTO of the combined company till a 2008 acquisition by Omniture (now part of Adobe). Mr. Rosenthal has a bachelor of science in computer science from MIT.. ...
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Ashley threw herself into running Alexanders therapy program full-time, and my daily routine as a work-from-home freelancer soon involved at least as much duty as a therapy assistant. The stress was enormous, and our debt grew whenever we sacrificed more work time for Alexanders sessions. For my wife, the manager of our ersatz team, administering the multiple programs meant constructing a self-made cage. Once, our professional lives had involved extended research trips, and now whole weeks could pass without either of us leaving the house except to ferry our daughter to and from school.. Still, we agreed that the strain on our family was far better than the despair of not knowing what to do. We believed, most of the time, that there was a smart little boy straining to emerge from those flapping, disorganized limbs. Alexanders program required a platoon of volunteer helpers, which meant most of our block knew all about his condition. The spring after he turned three, when he started to walk up ...
Abstract The members of the small heat shock protein (sHSP) family are molecular chaperones that play major roles in development, stress responses, and diseases, and have been envi..
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Dr. Alexander Donath, Sektionsleiter, Koordinator HPC-Cluster, -Bioinformatische Genomik, -Hochleistungsrechner, Tel.: +49 228 9122-344, Fax: +49 228 9122-295
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This week, a video showing a cat saving a 4-year-old California boy from a vicious dog attack went viral. The video shows the ... Dog Bites & Injuries
Parents often face a battle when it is time to travel with young children. For some, even a trip to the local grocery store ... blog
The mystery of the death of Alexander the Great, shrouded in intrigue, may have finally been solved, thanks to a team of academics, including a University of Birmingham toxicologist.
Fremont, CA (PRWEB) December 1, 2004 -- Everdream Corporation, the leader in hosted desktop IT services, today announced that Alexander Youth Network (AYN), a
A review of the Nobodys Baby by Leslie Alexander. Published June 13, 2011. ; !earshot magazine features campus/community radio charts, cd reviews, articles and interviews, label profiles and more.
Horizon 2020 Health, Demographic Change & Wellbeing EU funding, research and collaboration opportunities for 2016/17 Innovate UK funding opportunities in omics, bridging health and life sciences Dr Alexander
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Urmărim sfârşitul zilelor condamnatului irlandez, Alexander Pearce care aşteaptă să fie executat. Acţiunea se petrece în anul 1824, în colonia britanică a lui Van Diemen, unde viaţa este ceva mai dură ca în iad. Legat de un zid în întuneric, intr-o celulă din închisoarea Hobart, Pearce este vizitat de către Părintele Connolly, colegul sau irlandez, preotul parohiei fugit din colonie. Ultima mărturisire a lui Alexander Pearce va reda imaginea unei scene din iadul pe pământ şi suferinţa de neimagi ...
Suppose that in the future, cybernetics become so commmonplace that everyone has machine components implanted to enhance their ability to compete in the workforce. A sect arise who begin to genetically predispose their children to interface with these computer components, making them even more effective. Are these children still human? Would you oppose such genetic modification or would you yourself modify your children so that they would have the same enhancements and competitive edge? Why or why not? ...
ALL periods - be sure to put your Analog/Digital CER conclusion in your class period bin. I ONLY need that one sheet of paper. If you did it digitally, I STILL need it ...
Directed by Alexander Yan. With Lukas Gage, Betsy Holt, Bernadette Sullivan. A repressed young woman finds power in an act of deviance.
Hsp27, a small heat-shock protein, has important roles in many cellular processes, including cytoskeleton dynamics, cell differentiation, and apoptosis. Its expression in normal epidermis correlates with differentiation; however, little is known about the regulatory mechanisms involved. In this study, we report that Hsp27 undergoes upregulation, phosphorylation, and redistribution to the cytoskeleton during the late phase of epidermal keratinocyte differentiation. Our results also show that the expression of the dual leucine zipper-bearing kinase (DLK), an upstream activator of the MAP kinase pathways, is sufficient by itself to induce Hsp27 phosphorylation, cell periphery localization, and redistribution to the insoluble protein fraction (cytoskeleton) in poorly differentiated keratinocytes. This redistribution correlates with the insolubilization of cornified envelope-associated proteins such as involucrin. Interestingly, the effects of DLK on Hsp27 were blocked by PD98059, a selective ...
phdthesis{b8e3240b-679f-4607-910e-2b46d721ef7c, abstract = {Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimers and Parkinsons disease. sHsps are especially abundant in plants, where most are highly upregulated as the first line of defence against heat and other types of stress. sHsps are ATP-independent chaperones that contain a conserved α -crystallin domain with a characteristic β-sandwich fold, flanked by a flexible N-terminal region (NTR), which varies in length between different sHsps and a short C-terminal region (CTR), which contains a conserved I/V-X-I/V-motif important for oligomerization. Since sHsps are highly dynamic, only a few high-resolution structures are available. Most structures have either truncated or unresolved NTR. Hsp21, a dodecameric sHsp ...
Molecular biology of small heat shock protein mutations associated with Charcot-Marie-Tooth and distal hereditary motor neuropathies ...
Amyotrophic lateral sclerosis (ALS) is a disease of variable severity in terms of speed of progression of the disease course. We found a similar variability in disease onset and progression of 2 familial ALS mouse strains, despite the fact that they carry the same transgene copy number and express the same amount of mutant SOD1G93A messenger RNA and protein in the central nervous system. Comparative analysis of 2 SOD1G93A mouse strains highlights differences associated with the disease severity that are unrelated to the degree of motor neuron loss but that appear to promote early dysfunction of these cells linked to protein aggregation. Features of fast progressing phenotype are (1) abundant protein aggregates containing mutant SOD1 and multiple chaperones; (2) low basal expression of the chaperone alpha-B-crystallin (CRYAB) and β5 subunits of proteasome; and (3) downregulation of proteasome subunit expression at disease onset. In contrast, high levels of functional chaperones such as ...
Alexander disease is a rare, progressive, and generally fatal neurological disorder that results from dominant mutations affecting the coding region of GFAP, the gene encoding glial fibrillary acidic protein, the major intermediate filament protein of astrocytes in the central nervous system. A key step in pathogenesis appears to be the accumulation of GFAP protein within astrocytes to excessive levels. Studies using mouse models indicate that the severity of the phenotype correlates with the level of expression, and suppression of GFAP expression and/or accumulation is one strategy that is being pursued as a potential treatment. With the goal of identifying biomarkers that indirectly reflect the levels of GFAP in brain parenchyma, we have assayed GFAP levels in two body fluids in humans that are readily accessible as biopsy sites - cerebrospinal fluid and blood. We find that GFAP levels are consistently elevated in the CSF of Alexander disease patients, but only occasionally and modestly in ...
αB-Crystallin (αB) and HSP27 belong to the class of small Heat Shock Proteins (sHSPs) whose levels of expression increase under conditions of cellular stress, viz., heat, pH, and ischemia. sHSPs form an integral part of the cellular chaperone network by maintaining aggregation-prone proteins in a soluble state. Due to their tendency to form large oligomeric structures, human small heat shock factors have been refractory to structural studies. We are using a combination of solution-state and solid-state NMR approaches to define the structures of dimeric constructs and of large oligomers. Although the full extent of the functions of αB-Crystallin (αB) and HSP27 remain to be determined, the proteins are each implicated in certain inherited forms of dystrophies and αB is also implicated in breast and other forms of cancer.. The PhoQ/PhoP two-component regulatory system plays a critical role in bacterial virulence. PhoQ is a sensor kinase that is capable of sensing the environment in which the ...
Bacterial diversity analysis of moderately thermophilic microflora enriched by different energy sources In this study, cultures grown from explants of rabbit rib perichondrium were exposed to exogenously added transforming growth factor-beta 1 at concentrations of 0.1-10 ng/ml of media. Correlations with the Short Form-36 were used to investigate the convergent validity. Antioxidant status in ceftin dogs with idiopathic dilated cardiomyopathy. The pathological hallmark of Alexander disease is the inclusion body, known as Rosenthal fiber, within the cell bodies and processes of astrocytes. Although IL-4, IL-5, IL-10, and IL-13 each regulate distinct aspects of the granulomatous inflammatory response, IL-13 was identified as the primary mediator of liver fibrosis. Acute effect of whole body vibration on postural control in congenitally blind subjects: clarithromycin a preliminary evidence. Heterokaryons have been utilized for complementation and dominance testing of mutations that affect ...
Rosenthal 3 v National Academy for State Health Policy v © Feb 2006 v Systems Problems Errors occur because of systems problems -Shift focus from blaming individuals to safety improvement Preventing errors means designing safer systems of care
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Dr. Jeanne Rosenthal, MD, rated 4.3/5 by patients. 17 reviews, Phone number & practice locations, Ophthalmologist in New York, NY.
Complete information for HSPE1 gene (Protein Coding), Heat Shock Protein Family E (Hsp10) Member 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Prust et al, characterized 30 patients with Alexander disease and reviewed 185 previously reported cases in an effort to better determine the disease’s phenotypes and correlations with age at onset and genetic mutation. Based on their results, they propose to revise the Alexander’s disease subtypes from three to only two. Type I is characterized by early age at onset, seizures, encephalopathy, paroxysmal deterioration, failure to thrive, developmental delay and hallmark radiological features. In contrast, type II manifests across the lifespan and is characterized by autonomic dysfunction, bulbar symptoms, ocular movement abnormalities and palatal myoclonus and is largely without neurocognitive or developmental deficits.. Periklis Makrythanasis MD, PhD. http://www.neurology.org/content/77/13/1287.abstract?sid=fb3fb700-a768-4d35-a0b3-9d770db7cadf. ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor α family of cytokines that preferentially induces apoptosis in transformed cells, making it a promising cancer therapy. However, many neoplasms are resistant to TRAIL-induced apoptosis by mechanisms that are poorly understood. We demonstrate that the expression of the small heat shock protein αB-crystallin (but not other heat shock proteins or apoptosis-regulating proteins) correlates with TRAIL resistance in a panel of human cancer cell lines. Stable expression of wild-type αB-crystallin, but not a pseudophosphorylation mutant impaired in its assembly and chaperone function, protects cancer cells from TRAIL-induced caspase-3 activation and apoptosis in vitro. Furthermore, selective inhibition of αB-crystallin expression by RNA interference sensitizes cancer cells to TRAIL. In addition, wild-type αB-crystallin promotes xenograft tumor growth and inhibits TRAIL-induced apoptosis in vivo in nude
Distal hereditary motor neuronopathies (dHMNs) are a clinically and genetically heterogeneous group of disorders in which motor neurons selectively undergo age-dependant degeneration. Mutations in the small heat-shock protein HSPB1 (HSP27) are responsible for one form of dHMN. In this study, we have analysed the effect of expressing a form of mutant HSPB1 in primary neuronal cells in culture. Mutant (P182L) but not wild-type HSPB1 led to the formation of insoluble intracellular aggregates and to the sequestration in the cytoplasm of selective cellular components, including neurofilament middle chain subunit (NF-M) and p150 dynactin. These findings suggest a possible pathogenic mechanism for HSPB1 whereby the mutation may lead to preferential motor neuron loss by disrupting selective components essential for axonal structure and transport.
TY - JOUR. T1 - Structural and Mechanical Hierarchies in the α-Crystallin Domain Dimer of the Hyperthermophilic Small Heat Shock Protein Hsp16.5. AU - Bertz, Morten. AU - Chen, Jin. AU - Feige, Matthias J.. AU - Franzmann, Titus M.. AU - Buchner, Johannes. AU - Rief, Matthias. PY - 2010/7. Y1 - 2010/7. N2 - In biological systems, proteins rarely act as isolated monomers. Association to dimers or higher oligomers is a commonly observed phenomenon. As an example, small heat shock proteins form spherical homo-oligomers of mostly 24 subunits, with the dimeric α-crystallin domain as the basic structural unit. The structural hierarchy of this complex is key to its function as a molecular chaperone. In this article, we analyze the folding and association of the basic building block, the α-crystallin domain dimer, from the hyperthermophilic archaeon Methanocaldococcus jannaschii Hsp16.5 in detail. Equilibrium denaturation experiments reveal that the α-crystallin domain dimer is highly stable against ...

Understanding the molecular genetics of congenital cataract may have wider implications for age related cataract | British...Understanding the molecular genetics of congenital cataract may have wider implications for age related cataract | British...

Vicart P, Caron A, Guicheney P, et al. A missense mutation in the alpha B-crystallin chaperone gene causes a desmin-related ... Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2. ... The γ-crystallin gene cluster on chromosome 2q33-35 encompasses genes γA to D but only γC (CRYGC) and γD(CRYGD) are highly ... Heon E, Priston M, Schorderet DF, et al. The gamma-crystallins and human cataracts: a puzzle made clearer. Am J Hum Genet 1999; ...
more infohttp://bjo.bmj.com/content/88/1/2

RCSB PDB - Protein Feature View 









 - Alpha-crystallin B chain - P02510 (CRYAB BOVIN)RCSB PDB - Protein Feature View - Alpha-crystallin B chain - P02510 (CRYAB BOVIN)

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
more infohttp://www.rcsb.org/pdb/protein/P02510

CRYAA - Alpha-crystallin A chain - Cavia porcellus (Guinea pig) - CRYAA gene & proteinCRYAA - Alpha-crystallin A chain - Cavia porcellus (Guinea pig) - CRYAA gene & protein

IPR002068. A-crystallin/Hsp20_dom. IPR001436. Alpha-crystallin/HSP. IPR012274. Alpha-crystallin_A. IPR003090. Alpha-crystallin_ ... IPR002068. A-crystallin/Hsp20_dom. IPR001436. Alpha-crystallin/HSP. IPR012274. Alpha-crystallin_A. IPR003090. Alpha-crystallin_ ... help/chain target=_top>More...,/a>,/p>ChainiPRO_0000125852. 1 - 173. Alpha-crystallin A chainAdd BLAST. 173. ... sp,P68281,CRYAA_CAVPO Alpha-crystallin A chain OS=Cavia porcellus GN=CRYAA PE=1 SV=1 ...
more infohttp://www.uniprot.org/uniprot/P68281

Alpha crystallin B chain | definition of alpha crystallin B chain by Medical dictionaryAlpha crystallin B chain | definition of alpha crystallin B chain by Medical dictionary

What is alpha crystallin B chain? Meaning of alpha crystallin B chain medical term. What does alpha crystallin B chain mean? ... Looking for online definition of alpha crystallin B chain in the Medical Dictionary? alpha crystallin B chain explanation free ... redirected from alpha crystallin B chain) CRYAB. A gene on chromosome 11q22.3-q23.1 that encodes alpha crystallin B, a protein ... Alpha crystallin B chain , definition of alpha crystallin B chain by Medical dictionary https://medical-dictionary. ...
more infohttp://medical-dictionary.thefreedictionary.com/alpha+crystallin+B+chain

CRYAA - Crystallin alpha A - Daptrius ater - CRYAA gene & proteinCRYAA - Crystallin alpha A - Daptrius ater - CRYAA gene & protein

Alpha-crystallin A chain. CHICK. 173. UniRef50_P02504. Alpha A-crystallin (Fragment). LOPNY ... IPR002068 A-crystallin/Hsp20_dom. IPR001436 Alpha-crystallin/HSP. IPR012274 Alpha-crystallin_A. IPR003090 Alpha-crystallin_N. ... IPR002068 A-crystallin/Hsp20_dom. IPR001436 Alpha-crystallin/HSP. IPR012274 Alpha-crystallin_A. IPR003090 Alpha-crystallin_N. ... Crystallin alpha AImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a ...
more infohttps://www.uniprot.org/uniprot/B4Z7V1

HKU Scholars Hub: Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and...HKU Scholars Hub: Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and...

alpha-Crystallin B Chain - physiology. -. dc.title. Identification of tumor suppressive activity by irradiation microcell- ... The association of alpha B-crystallin (CRYAB), a gene identified as being differentially expressed by gene profiling of NPC and ... The association of alpha B-crystallin (CRYAB), a gene identified as being differentially expressed by gene profiling of NPC and ... Alpha B-crystallin (CRYAB). Chromosome 11q. Irradiation microcell-mediated chromosome transfer. Microcell hybrid. ...
more infohttp://hub.hku.hk/handle/10722/58245

Anti-alpha A Crystallin/CRYAA antibody (ab5595) | AbcamAnti-alpha A Crystallin/CRYAA antibody (ab5595) | Abcam

Rabbit polyclonal alpha A Crystallin/CRYAA antibody. Validated in WB, IHC, BL, sELISA and tested in Mouse, Rat, Cow. Cited in ... O-glycosylated; contains N-acetylglucosamine side chains.. Deamidation of Asn-101 in lens occurs mostly during the first 30 ... Alpha-crystallin is the largest of the crystallins and is composed of 2 primary gene products--alpha-A and alpha-B. There are ... Biochimica et Biophysica Acta 1991 v1080 p173-180) describes the alpha-A crystallin and how it is split into alpha-A1 and alpha ...
more infohttps://www.abcam.com/alpha-a-crystallincryaa-antibody-ab5595.html

Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics...Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics...

L-lactate dehydrogenase B chain; CRYAB: Alpha-crystallin B chain; YBX1: Nuclease-sensitive element-binding protein 1; PRKDC: ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/31231467

Human Hsp22 peptide (ab22992) | AbcamHuman Hsp22 peptide (ab22992) | Abcam

Alpha crystallin C chain. *Alpha-crystallin C chain. *Charcot Marie Tooth disease axonal type 2L ...
more infohttps://www.abcam.com/human-hsp22-peptide-ab22992.html

CRYA1 (human)CRYA1 (human)

Alpha-crystallin A chain Show on y-axis - References (HTP + LTP). References (LTP). References (HTP). Mutation Frequency in ...
more infohttps://www.phosphosite.org/proteinAction.action?id=5658&showAllSites=true

All Gene list by Location (Kb)All Gene list by Location (Kb)

crystallin alpha A. LOC102724652 43169.041. 21p12. alpha-crystallin A chain. LINC00322 43322.209. 21q22.3. long intergenic non- ... collagen type VI alpha 1 chain. COL6A2 46098.119. 21q22.3. collagen type VI alpha 2 chain. ...
more infohttp://atlasgeneticsoncology.org/Indexbychrom/idxg_21.html

Alpha crystallin B chain Control PeptideAlpha crystallin B chain Control Peptide

Alpha_crystallin B chain Control Peptide - Gentaur molecular products ... We have also other products like : Alpha crystallin B chain Control Peptide Related products : Alpha crystallin B chain Control ... Index / ACR / Alpha crystallin B chain Control Peptide /Product Detail : NB100-2520PEP Alpha crystallin B chain Control Peptide ...
more infohttps://www.antibody-antibodies.com/product148019/acr-alpha-crystallin-b-chain-control-peptide.html

The Entotympanic of Pangolins and the Phylogeny of the Pholidota (Mammalia) | SpringerLinkThe Entotympanic of Pangolins and the Phylogeny of the Pholidota (Mammalia) | SpringerLink

McKenna, M. C. (1992). The alpha crystallin A chain of the eye lens and mammalian phylogeny. Ann. Zool. Fenn. 28: 349-360. ...
more infohttps://link.springer.com/article/10.1023%2FA%3A1020538313412

SDS-PAGE analysis of UV-A-exposed and unexposed WT α | Open-iSDS-PAGE analysis of UV-A-exposed and unexposed WT α | Open-i

SDS-PAGE analysis of UV-A-exposed and unexposed WT αB-crystallin and its three deamidated mutant species. After UV-A-exposure ... alpha-Crystallin B Chain/chemistry*/isolation & purification/metabolism*. Minor. *Amino Acid Sequence ... The WT alphaB-crystallin and its three deamidated species were exposed to UV-A light (320-400 nm) at intensities of 20 or 50 J/ ... The WT alphaB-crystallin and its three deamidated species were exposed to UV-A light (320-400 nm) at intensities of 20 or 50 J/ ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2255029_mv-v14-234-f1&req=4

Generation of the required genotypes of mice.(A) Schema | Open-iGeneration of the required genotypes of mice.(A) Schema | Open-i

The KO and KOTg samples were devoid of αB-crystallin as expected. WT samples showed higher amounts of αB-crystallin than WTTg ... The KO and KOTg samples were devoid of αB-crystallin as expected. WT samples showed higher amounts of αB-crystallin than WTTg ... We hypothesized that αB-crystallin protects cells against Aβ toxicity. To test this, we crossed αB-crystallin/HspB2 deficient ( ... We hypothesized that αB-crystallin protects cells against Aβ toxicity. To test this, we crossed αB-crystallin/HspB2 deficient ( ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3040748_pone.0016550.g002&req=4

Heat Shock Proteins in Human Endometrium Throughout the Menstrual CycleHeat Shock Proteins in Human Endometrium Throughout the Menstrual Cycle

The maximal expression of the molecular chaperone, alpha crystallin B chain, occurs during the secretory phase. In view of ... and alpha crystallin B chain. The expression of Hsp27, Hsp60, and the constitutive form of Hsp70 (Hsc70) shows a sharp increase ...
more infohttps://www.hindawi.com/journals/idog/1999/404213/abs/

Shop & Learn about Monoclonal Antibodies - MyBioSourceShop & Learn about Monoclonal Antibodies - MyBioSource

Alpha-crystallin A chain; Heat shock protein beta 4; Acry-1; Alpha crystallin A chain; CRYA 1; Crystallin Alpha 1; Crystallin ... Anti -a-Fetoprotein; NT (Alpha-1-fetoprotein; Alpha-fetoglobulin; Alpha-fetoprotein precursor; HPAFP); alpha-fetoprotein ... alpha/beta SNAP; mouse anti alpha/beta soluble NSF attachment protein; alpha-soluble NSF attachment protein; N-ethylmaleimide- ... a-Fetoprotein, NT (Alpha-1-fetoprotein, Alpha-fetoglobulin, Alpha-fetoprotein precursor, FETA, HPAFP). ...
more infohttps://www.mybiosource.com/monoclonal

Purified anti-Alpha Crystallin B Antibody by BioLegendPurified anti-Alpha Crystallin B Antibody by BioLegend

Purified anti-Alpha Crystallin B - read details of BioLegend antibodies in the SelectScience.net Antibody products and ... Alpha-crystallin B chain, alpha B crystallin, heat shock protein beta-5, rosenthal fiber component, heat-shock 20 kD like- ... Purified anti-Alpha Crystallin B. Be the first to review this product ... Purified anti-Alpha Crystallin B; Clone: Poly9079; Reactivity: Human, Mouse; Apps: IHC, WB; Size: 200 μl ...
more infohttp://www.selectscience.net/antibodyProductDetails.aspx?antibodyID=43533

ZFIN Publication: Zou et al., 2015ZFIN Publication: Zou et al., 2015

Real-Time Polymerase Chain Reaction. *Zebrafish/embryology*. *alpha-Crystallin A Chain/physiology* ... Alpha-crystallin, TALEN, cataract, chaperone, lens development, maternal transcript, morpholino, small heat shock protein, ... αA- and αB-crystallins are small heat shock proteins that bind thermodynamically destabilized proteins thereby inhibiting their ... Here, we have examined the role of α-crystallins in the development of the vertebrate zebrafish lens. For this purpose, we have ...
more infohttp://zfin.org/ZDB-PUB-150708-6

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Alpha-crystallin A chain / CRYA1 (1-175). Nicht möglich. Mouse. Purified. > 95 % > 95 % by SDS PAGE. E. coli. 0.5 mg / 820,00 € ... Alpha-crystallin A chain / CRYA1 (1-175). Nicht möglich. Mouse. Purified. > 95 % > 95 % by SDS PAGE. E. coli. 0.1 mg / 320,00 € ...
more infohttps://www.acris-antikoerper.de/proteins-growth-factors.htm?ag_species=Mouse

Sharon Pitteri | Stanford Medicine ProfilesSharon Pitteri | Stanford Medicine Profiles

Tandem mass spectrometry was applied both to ions of a tryptic fragment and intact protein of bovine alpha-crystallin A chain ... The [M + 19H](19+) to [M + 11H](11+) charge states of both phosphorylated and unphosphorylated bovine alpha-crystallin A chain ... A tryptic digest of the bovine alpha-crystallin A chain yielded a phosphopeptide containing one missed cleavage site. The ... Bovine alpha-crystallin A chain ANALYTICAL CHEMISTRY Hogan, J. M., Pitteri, S. J., McLuckey, S. A. 2003; 75 (23): 6509-6516 ...
more infohttps://med.stanford.edu/profiles/sharon-pitteri?tab=research-and-scholarship

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Alpha-crystallin A chain / CRYA1 Antikörper. Nicht möglich. CRYAA (Alpha A Crystallin) mouse monoclonal antibody, Clone , clone ... Alpha-crystallin B chain / CRYA2 Antikörper. Nicht möglich. CRYAB (Alpha B Crystallin) mouse monoclonal antibody, clone OTI6D11 ... Alpha-2-HS-glycoprotein / AHSG Antikörper. Nicht möglich. AHSG (alpha-2-HS-glycoprotein) mouse monoclonal antibody, clone ... Alpha-crystallin A chain / CRYA1 (1) * Alpha-crystallin B chain / CRYA2 (1) ...
more infohttps://www.acris-antikoerper.de/topseller.htm

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Alpha-crystallin A chain / CRYA1 anticorps. Not available. CRYAA (Alpha A Crystallin) mouse monoclonal antibody, Clone , clone ... Alpha-crystallin B chain / CRYA2 anticorps. Not available. CRYAB (Alpha B Crystallin) mouse monoclonal antibody, clone OTI6D11 ... Alpha-2-HS-glycoprotein / AHSG anticorps. Not available. AHSG (alpha-2-HS-glycoprotein) mouse monoclonal antibody, clone OTI2H2 ... Alpha-crystallin A chain / CRYA1 (1) * Alpha-crystallin B chain / CRYA2 (1) ...
more infohttps://www.acris-anticorps.fr/topseller.htm

Gradishar, W. J.<...Gradishar, W. J.<...

Targeting alpha B-Crystallin in Basal-like Breast Cancer. Gradishar, W. J. ...
more infohttps://www.scholars.northwestern.edu/en/persons/william-j-gradishar
  • Three deamidated mutants previously generated from recombinant WT alphaB-crystallin, using a site-specific mutagenesis procedure as previously described , were used. (nih.gov)
  • Based on our observations of reduced αB-crystallin in older transgenic but not in non-transgenic mice, we hypothesized that if this chaperone is protective, then its loss may show an exaggerated phenotype. (nih.gov)
  • Alpha-B crystallin has been linked to Alexander's disease where it accumulates in brain cells of those afflicted. (abcam.com)
  • Among the four spots recovered after two-dimensional (2D)-gel electrophoresis from WT and the three deamidated species, the Met and Trp residues of alphaB-Asn146Asp mutant showed maximum oxidation after UV-A exposure, which might account for its greater loss in chaperone activity compared to WT alphaB-crystallin and two other deamidated species. (nih.gov)
  • Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (wikipedia.org)