Progesterone Congeners
Crystallins
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.
alpha-Crystallins
A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Lens, Crystalline
gamma-Crystallins
beta-Crystallins
A class of crystallins that provides refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits.
Ricin
alpha-Crystallin A Chain
alpha-Crystallin B Chain
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
delta-Crystallins
Cataract
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Abrin
A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different proteins have so far been isolated: Abrus agglutinin, the component responsible for: hemagglutinating activity, & abrins a-d, the toxic principals each consisting of two peptide chains are held together by disulfide bonds.
Bungarus
Base Sequence
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
alpha 1-Antitrypsin
Macromolecular Substances
Alterations in the mouse and human proteome caused by Huntington's disease. (1/314)
Huntington's disease is an autosomal dominantly inherited disease that usually starts in midlife and inevitably leads to death. In our effort to identify proteins involved in processes upstream or downstream of the disease-causing huntingtin, we studied the proteome of a well established mouse model by large gel two-dimensional electrophoresis. We could demonstrate for the first time at the protein level that alpha1-antitrypsin and alphaB-crystalline both decrease in expression over the course of disease. Importantly, the alpha1-antitrypsin decrease in the brain precedes that in liver and testes in mice. Reduced expression of the serine protease inhibitors alpha1-antitrypsin and contraspin was found in liver, heart, and testes close to terminal disease. Decreased expression of the chaperone alphaB-crystallin was found exclusively in the brain. In three brain regions obtained post-mortem from Huntington's disease patients, alpha1-antitrypsin expression was also altered. Reduced expression of the major urinary proteins not found in the brain was seen in the liver of affected mice, demonstrating that the disease exerts its influence outside the brain of transgenic mice at the protein level. Maintaining alpha1-antitrypsin and alphaB-crystallin availability during the course of Huntington's disease might prevent neuronal cell death and therefore could be useful in delaying the disease progression. (+info)The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. (2/314)
Myoblasts respond to growth factor deprivation either by differentiating into multinucleated myotubes or by undergoing apoptosis; hence, the acquisition of apoptosis resistance by myogenic precursors is essential for their development. Here we demonstrate that the expression of the small heat shock protein alpha B-crystallin is selectively induced in C2C12 myoblasts that are resistant to differentiation-induced apoptosis, and we show that this induction occurs at an early stage in their differentiation in vitro. In contrast, the expression of several known anti-apoptotic proteins (FLIP, XIAP, Bcl-x(L)) was not altered during myogenesis. We also demonstrate that ectopic expression of alpha B-crystallin, but not the closely related small heat shock protein Hsp27, renders C2C12 myoblasts resistant to differentiation-induced apoptosis. Furthermore, we show that the myopathy-causing R120G alpha B-crystallin mutant is partly impaired in its cytoprotective function, whereas a pseudophosphorylation alpha B-crystallin mutant that mimics stress-induced phosphorylation is completely devoid of anti-apoptotic activity. Finally, we demonstrate that alpha B-crystallin negatively regulates apoptosis during myogenesis by inhibiting the proteolytic activation of caspase-3, whereas the R120G and pseudophosphorylation mutants are defective in this function. Taken together, our findings indicate that alpha B-crystallin is a novel negative regulator of myogenic apoptosis that directly links the differentiation program to apoptosis resistance. (+info)Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genes. (3/314)
The mouse Shsp/alphaB-crystallin and Mkbp/HspB2 genes are closely linked and divergently transcribed. In this study, we have analyzed the contribution of the intergenic enhancer to Shsp/alphaB-crystallin and Mkbp/HspB2 promoter activity using dual-reporter vectors in transient transfection and transgenic mouse experiments. Deletion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 30- and 93-fold and Mkbp/HspB2 promoter activity by 6- and 10-fold in transiently transfected mouse lens alpha-TN4 and myoblast C2C12 cells, respectively. Surprisingly, inversion of the enhancer reduced Shsp/alphaB-crystallin promoter activity by 17-fold, but did not affect Mkbp/HspB2 promoter activity in the transfected cells. In contrast, enhancer activity was orientation-independent in combination with a heterologous promoter in transfected cells. Transgenic mouse experiments established the orientation dependence and Shsp/alphaB-crystallin promoter preference of the intergenic enhancer in its native context. The orientation dependence and preferential effect of the Shsp/alphaB-crystallin enhancer on the Shsp/alphaB-crystallin promoter provide an example of adaptive changes in gene regulation accompanying the functional diversification of duplicated genes during evolution. (+info)Retinal pigment epithelium is protected against apoptosis by alphaB-crystallin. (4/314)
PURPOSE: The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the expression of the small heat shock protein alphaB-crystallin in the RPE in response to oxidative stress and to explore whether alphaB-crystallin expression confers an antiapoptotic cytoprotective effect on RPE cells. METHODS: Native human RPE cells from the macula and retinal periphery were analyzed by RT-PCR and Western blot analysis for expression of alphaB-crystallin. Monolayer cultures of human RPE cells were stressed by heat shock (42 degrees C for 20 minutes) or oxidant-mediated injury (50-300 micro M H(2)O(2) for 1 hour). Induction of alphaB-crystallin and the corresponding mRNA was assessed by Western and Northern blot analyses. To study the cytoprotective effect of alphaB-crystallin, human RPE cells were transfected with either a neomycin-selectable expression vector containing alphaB-crystallin cDNA or a control vector without alphaB-crystallin cDNA. Caspase-3 activity was determined by observing the cleavage of a colorimetric peptide substrate. Cell viability was quantified by combined propidium iodide and Hoechst 33342 staining. RESULTS: alphaB-crystallin is constitutively expressed in RPE under in vivo and in vitro conditions. Western blot analysis of freshly isolated RPE showed greater baseline expression levels in RPE derived from the macular area than in that from the more peripheral regions. Heat shock treatment and oxidative stress caused a significant increase in alphaB-crystallin mRNA and protein. Oxidant-mediated injury in RPE cells with baseline expression levels of alphaB-crystallin resulted in apoptotic cell death, as measured by caspase-3 activity, whereas RPE cells that had been stably transfected with alphaB-crystallin were more resistant to H(2)O(2)-induced cellular injury. CONCLUSIONS: alphaB-crystallin may function as a stress-inducible antiapoptotic protein in human RPE and is inducible by oxidative stress, a condition implicated in the pathogenesis of AMD. Overexpression of alphaB-crystallin may be an important mechanism for the RPE to prevent apoptotic cell death in response to cellular stress. (+info)The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination. (5/314)
AlphaB-crystallin is a small heat-shock protein in which three serine residues (positions 19, 45, and 59) can be phosphorylated under various conditions. We describe here the interaction of alphaB-crystallin with FBX4, an F-box-containing protein that is a component of the ubiquitin-protein isopeptide ligase SCF (SKP1/CUL1/F-box). The interaction with FBX4 was enhanced by mimicking phosphorylation of alphaB-crystallin at both Ser-19 and Ser-45 (S19D/S45D), but not at other combinations. Ser-19 and Ser-45 are preferentially phosphorylated during the mitotic phase of the cell cycle. Also alphaB-crystallin R120G, a mutant found to co-segregate with a desmin-related myopathy, displayed increased interaction with FBX4. Both alphaB-crystallin S19D/S45D and R120G specifically translocated FBX4 to the detergent-insoluble fraction and stimulated the ubiquitination of one or a few yet unknown proteins. These findings implicate the involvement of alphaB-crystallin in the ubiquitin/proteasome pathway in a phosphorylation- and cell cycle-dependent manner and may provide new insights into the alphaB-crystallin-induced aggregation in desmin-related myopathy. (+info)Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of two-mode binding in alphaB-crystallin. (6/314)
The consequences of alphaB-crystallin phosphorylation on its chaperone activity were investigated using a detailed analysis of the recognition and binding of destabilized T4 lysozyme (T4L) mutants by alphaB-crystallin phosphorylation mimics containing combinations of serine to aspartate substitutions. The T4L site-directed mutants were selected to constitute an energetic ladder of progressively destabilized proteins having similar structures in the folded state. alphaB-crystallin and its variants differentially recognize the T4L mutants, binding the more destabilized ones to a larger extent. Furthermore, the aspartate substitutions result in an increase in the extent of binding to the same T4L mutant and in the appearance of biphasic binding isotherms. The latter indicates the presence of two modes of binding characterized by different affinities and different numbers of binding sites. The transition to two-mode binding can also be induced by temperature or pH activation of the second mode. The similarity between the phosphorylation, pH, and temperature effects suggests a common structural origin. The location of the phosphorylation sites in the N-terminal domain and the hypothesized burial of this domain in the core of the oligomeric structure are consistent with a critical role for the destabilization of the quaternary structure in the process of recognition and binding by small heat-shock proteins. (+info)Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. (7/314)
BACKGROUND: One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO). METHODS: Lenses from 129SvEvTac mice and alpha A/BKO mice were examined by standard scanning electron microscopy and confocal microscopy methodologies. RESULTS: Equatorial and axial (sagittal) dimensions of lenses for alpha A/BKO mice were significantly smaller than age-matched wild type lenses. No posterior sutures or fiber cells extending to the posterior capsule of the lens were found in alpha A/BKO lenses. Ectopical nucleic acid staining was observed in the posterior subcapsular region of 5 wk and anterior subcapsular cortex of 54 wk alpha A/BKO lenses. Gross morphological differences were also observed in the equatorial/bow, posterior and anterior regions of lenses from alpha A/BKO mice as compared to wild mice. CONCLUSION: These results indicated that both alpha A- and alpha B-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation. (+info)Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis. (8/314)
AlphaB-crystallin (alphaBC), a small heat shock protein expressed in high levels in the heart, is phosphorylated on Ser-19, 45, and 59 after stress. However, it is not known whether alphaBC phosphorylation directly affects cell survival. In the present study, constructs were prepared that encode forms of alphaBC harboring Ser to Ala (blocks phosphorylation) or Ser to Glu (mimics phosphorylation) mutations at positions 19, 45, and 59. The effects of each form on apoptosis of cultured cardiac myocytes after hyperosmotic or hypoxic stress were assessed. Compared with controls, cells that expressed alphaBC with Ser to Ala substitutions at all three positions, alphaBC(AAA), exhibited more stress-induced apoptosis. Cells expressing either alphaBC(AAE) or (EEE) exhibited 3-fold less apoptosis than cells expressing alphaBC(AAA), indicating that phosphorylation of Ser-59 confers protection. alphaBC is known to bind to procaspase-3 and to decrease caspase-3 activation. Compared with cells expressing alphaBC(AAA), the activation of caspase-3 was decreased by 3-fold in cells expressing alphaBC(AAE). These results demonstrate that mimicking the phosphorylation of alphaBC on Ser-59 is necessary and sufficient to confer caspase-3 inhibition and protection of cardiac myocytes against hyperosmotic or hypoxic stress. These findings provide direct evidence that alphaBC(S59P) contributes to the cardioprotection observed after physiologically relevant stresses, such as transient hypoxia. Identifying the targets of alphaBC(S59P) will reveal important details about the mechanism underlying the cytoprotective effects of this small heat shock protein. (+info)
alphaB-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression
Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the...
Browse our CRYAB ELISA Kits
P. de Ronsard; Oeuvres Poétiques: Index Alphabétique (French Edition) Vaganay, Hugues » holypet.ru
Liste alphabétique des applications, logiciels et plateformes SAP
IU School of Medicine discovery may lead to precision-based strategy for triple negative breast cancer
Mitochondrial Dysfunction and Apoptosis Underlie the Pathogenic Process in α-B-Crystallin Desmin-Related Cardiomyopathy |...
Abstract 258: Human 450delACryAB Overexpression Associated with Protein Aggregation Uncovers a Novel Mechanism for Inheritable...
A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy. - PubMed - NCBI
Matrix metalloproteinase-1 induces cleavage of exogenous alphab-crystallin transduced by a cell-penetrating peptide<...
Active H2 :: Oxidative Stress
Reductive Stress: An Argument Against Anti-Oxidants for Athletes & Everyone Else? Plus: AGE-Reduced Diets for Health & Weight...
The Probabilities of Oddities : Jeffrey Rosenthal
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Alexander Disease, symptoms and Alexander Disease treatments
P62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic...
CRYAB - Wikipedia
Alexander Disease - National Stem Cell Foundation
Adult-onset Alexander disease, associated with a mutation in an alternative GFAP transcript, may be phenotypically modulated by...
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R120G αB-crystallin promotes the unfolding of reduced α-lactalbumin an by T. M. Treweek, A. Rekas et al.
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Novelties | Rosenthal Porcelain Online Shop
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Alexander disease - Wikipedia
Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. - open
Genetic variation of alphaB-crystallin in multiple sclerosis, hypertrophic cardiomyopathy and dilated cardiomyopathy</em>...
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DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21)
DNAJC4 (DnaJ heat shock protein family (Hsp40) member C4)
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Elucidating a Precise Role for the Small Heat Shock Proteins CryAB and HspB2 in Cardiac Robustness
Hspb11 MGI Mouse Gene Detail - MGI:1920188 - heat shock protein family B (small), member 11
Alexander disease
Albee Messing VMD, PhD
Curated Information
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Helianthus annuus hsp17.6 G1 protein
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Publications scientifiques | CépiDc
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CRYAA
Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Crystallins are separated into two classes: ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an ...
CRYAB
... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Alpha B chain crystallins (αBC) can be induced by heat shock, ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. These ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein ...
List of MeSH codes (D12.776)
... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate dehydrogenase MeSH D12.776.377.715.085.050 - alpha 1- ... immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - immunoglobulin alpha-chains MeSH D12.776.377.715.548.705. ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
CRYBB2
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as ... "Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2 ... Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four ... Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene. Crystallins are separated into two classes: taxon ...
Chromosome 1
Crystallin zeta CYP4B1 (1p33) CYR61 (1p22) DBT: dihydrolipoamide branched chain transacylase E2 DCLRE1B: DNA cross-link repair ... encoding protein Sterile alpha motif domain containing 11 SDC3: Syndecan-3 SDHB (1p36) SFPQ (1p34) SGIP1: SH3 domain GRB2-like ... 1 alpha subcomplex, 4, 9kda, pseudogene 1 NGF: Nerve Growth Factor NOL9: Nucleolar protein 9 NRAS (1p13) NOTCH2 (1p12) OLFML3: ... encoding TNF alpha induced protein 8 like 2 TNFSF18 (1q25) TNN (1q25) TNNT2: cardiac troponin T2 TOR1AIP1: Torsin-1A- ...
Chromosome 21
... encoding alpha-2 chain of collagen VI COL18A1: encoding alpha-1 chain of collagen XVIII CRYAA: encoding alpha-crystallin A ... encoding GA-binding protein alpha chain GART: encoding enzyme trifunctional purine biosynthetic protein adenosine-3 GATD3A: ... encoding interferon alpha/beta receptor 1 IFNAR2: encoding interferon alpha/beta receptor 2 IFNGR1: encoding interferon gamma ... chain CRYZL1: Crystallin zeta-like 1 CXADR: encoding protein coxsackievirus and adenovirus receptor CYYR1: Cysteine and ...
Aldo-keto reductase
... rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide ... Some proteins of this family contain a potassium channel beta chain regulatory domain; these are reported to have ... The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in ...
Pathophysiology of multiple sclerosis
Bsibsi M, Holtman IR, Gerritsen WH, Eggen BJ, Boddeke E, van der Valk P, van Noort JM, Amor S (2013). "Alpha-B-Crystallin ... free light chains (FLC). Several authors have reported that they are comparable or even better than oligoclonal bands. Multiple ...
Perlecan
The N-terminal domain I (aa ~1-195) contains attachment sites for HS chains. Although HS chains are not required for correct ... To this end, a transgenic mouse line was created expressing porcine TGF-β1 under the lens-specific αA-crystallin promoter and ... In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain ... Domain V also has attachment sites for HS/CS chains. Thus, perlecan core protein and HS chains could modulate matrix assembly, ...
List of A1 genes, proteins or receptors
... alpha 1 Collagen, type XIX, alpha 1 Collagen, type XXV, alpha 1 Collagen, type XXVII, alpha 1 Crystallin, beta A1 Cyclic ... DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein NADH ... alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ...
Protein footprinting
Shum WK, Maleknia SD, Downard KM (September 2005). "Onset of oxidative damage in alpha-crystallin by radical probe mass ... The rate or level of oxidation at the reactive amino acid side chains (Met, Cys, Trp, Tyr, Phe, His, Pro and Leu) provides a ... The mechanisms of side chain oxidation were explored by performing the radiolysis reactions in 18O-labeled water. A critical ... Downard KM, Kokabu Y, Ikeguchi M, Akashi S (November 2011). "Homology-modelled structure of the βB2B3-crystallin heterodimer ...
Ageing
The cause is lens hardening by decreasing levels of alpha-crystallin, a process which may be sped up by higher temperatures. ... The authors propose that mtDNA mutations lead to respiratory-chain-deficient cells and thence to apoptosis and cell loss. They ... the Growth hormone/Insulin-like growth factor 1 signalling pathway the activity levels of the electron transport chain in ...
Protease inhibitor (biology)
The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... is a double-chain inhibitor consisting of an 11-residue and a 41-residue chain. The Carboxypeptidase inhibitor I68 family ... The yeast killer toxin structure was thought to be a precursor of the two-domain beta gamma-crystallin proteins, because of its ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ...
Argininosuccinate lyase
Domain 2 contains one small beta sheet, nine alpha helices, and the carboxyl terminus. Three of the nine alpha helices on one ... δ-crystallins are the major structural eye lens water-soluble proteins of most birds, reptiles, and some other vertebrates. ... ASL is composed of four identical monomers; each monomer consisting of a single polypeptide chain between 49 and 52 kDa, ... Two dimers then associate by way of alpha helix, one from each monomer, to form a central 20-helix core. The association of all ...
Sean M. Decatur
Silva, R.A.G.D., *Nguyen, J.Y., and Decatur, S.M. (2002) "Probing the Effects of Side Chains on the Conformation and Stability ... "Formation of Amyloid Fibrils in Vitro by Human γd-crystallin and its Isolated Domains," Molecular Vision 14:81-89. Decatur, S.M ... "Two dimensional infrared measurements of the coupling of the amide modes of an alpha helix," Chemical Physics Letters 382: 586- ... "Twodimensional IR Spectroscopy and Segmental 13C Labeling reveals the Domain Structure of Human γδ-crystallin amyloid fibrils ...
Glucosepane
These compounds are thought to act as bidentate nucleophiles that attack the adjacent carbonyls in the alpha-dicarbonyl ... and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane ... This then condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the ... such as collagen in the skin and crystallin in the eyes. Skin collagen, for instance, has a half-life of fifteen years. Because ...
Charles Daniel Lane
The translation of reticulocyte 9S RNA in frog oocytes gives rise to alpha and beta globin chains. Communication to FEBS ... Berns, A. J. M.; Kraaikamp, M. Van; Bloemendal, H.; Lane, C. D. (1972). "Calf Crystallin Synthesis in Frog Cells: The ...
List of MeSH codes (D08)
... cholesterol side-chain cleavage enzyme MeSH D08.244.453.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.244.453.915 ... delta-crystallins MeSH D08.811.520.232.400 - ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811 ... cholesterol side-chain cleavage enzyme MeSH D08.811.682.690.708.170.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH ... cholesterol 7 alpha-hydroxylase MeSH D08.811.682.690.708.783.212 - cholesterol side-chain cleavage enzyme MeSH D08.811.682.690. ...
Transketolase
... and aspartate side-chains, with a glutamate side-chain playing a secondary role. These side-chains, to be specific Arg359, ... and Asp477 forms hydrogen bonds with the alpha hydroxyl group on the substrate, where it works to effectively bind the ... in the mammalian cornea by the stromal keratocytes and epithelial cells and is reputed to be one of the corneal crystallins. ... To be specific, the His 263 and His30 side-chains form hydrogen bonds to the aldehyde end of the substrate, which is deepest ...
List of distinct cell types in the adult human body
... alpha and gamma-endorphin, bombesin Thyroid gland cells Thyroid epithelial cell Parafollicular cell Parathyroid gland cells ... Intermediate skeletal muscle cell Nuclear bag cell of muscle spindle Nuclear chain cell of muscle spindle Myosatellite cell ( ... Medium spiny neurons Astrocytes Oligodendrocytes Ependymal cells Tanycytes Pituicytes Anterior lens epithelial cell Crystallin- ... Parathyroid chief cell Oxyphil cell Pancreatic islets (islets of Langerhans) Alpha cell (secretes glucagon) Beta cell (secretes ...
Proteinopathy
Ecroyd H, Carver JA (January 2009). "Crystallin proteins and amyloid fibrils". Cellular and Molecular Life Sciences. 66 (1): 62 ... Badar T, D'Souza A, Hari P (2018). "Recent advances in understanding and treating immunoglobulin light chain amyloidosis". ... "Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein". Proceedings of the ... In immunoglobulin light chain amyloidosis (AL amyloidosis), chemotherapy can be used to lower the number of the blood cells ...
Amyloid beta
"Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the ... Oligomerization is a chemical process that converts individual molecules into a chain consisting of a finite number of ... Intra-cellular deposits of tau protein are also seen in the disease, and may also be implicated, as has aggregation of alpha ... leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in ...
"alpha-Crystallin B Chain/genetics/*physiology" | Glembotski...
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio
Light scattering of human lens vesicles in vitro
... was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. Increased ... The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. Hydrocarbon chain ... lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid ...
GlyConnect
32 Alpha crystallin - a and b chains Bos taurus P02510 # id : 32 Alpha crystallin - a and b chains Bos taurus ... 33 Alpha crystallin - a and b chains Homo sapiens P02489 # id : 33 Alpha crystallin - a and b chains Homo sapiens ... 34 Alpha crystallin - a and b chains Rattus norvegicus P24623 # id : 34 Alpha crystallin - a and b chains Rattus norvegicus ... Alpha crystallin - a and b chains / Bos taurus P02470 P02510 # Export GlyConnect protein list related to protein with id 32 ...
GlyConnect
Alpha crystallin b chain (b2 subunit) (Bos taurus). All glycosylation sites SNFG, Text, Oxford ... Alpha crystallin b chain (b2 subunit) / Bos taurus P02510 # Export GlyConnect protein list related to glycosylation_site_ ... structure with id 3800000008849 P02510 # id : 38 Alpha crystallin b chain (b2 subunit) Bos taurus ... Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (1991 - Roquemore E, Dell A, Hart G) / Status : ...
GeniePlex Rat LIX/GCP2/CXCL5 Multiplex Assay
DeCS
alpha-Crystallin B Chain Entry term(s). B Chain, alpha-Crystallin B Subunit alpha-Crystallin Crystallins, alpha B Chain ... alpha B Crystallin alpha B-Crystallin alpha Crystallin B Chain alpha Crystallin, B Subunit alpha-Crystallin, B Subunit ... alpha B Crystallin. alpha B-Crystallin. alpha Crystallin B Chain. alpha Crystallin, B Subunit. alpha-Crystallin, B Subunit. ... Chaîne B de la cristalline alpha Entry term(s):. B Chain, alpha-Crystallin. B Subunit alpha-Crystallin. Crystallins, alpha B ...
Infantile muscular dystrophy in Canadian aboriginals is an αb-crystallinopathy<...
Crystallins Medicine & Life Sciences 72% * alpha-Crystallin B Chain Medicine & Life Sciences 48% ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ...
IMSEAR at SEARO: Search
CRYAB Antibody Monoclonal | HSPB5 Antibody | ProSpec
Alpha crystallins are composed of two gene products; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Mouse IgG2b heavy chains and κ light chain.. Purification Method. CRYAB antibody was purified from mouse ascitic fluids by ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of -crystallins are an autokinase ... Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. ...
Pesquisa | Prevenção e Controle de Câncer
... alpha 1; CRYBA1: crystallin, beta A1; DAPI: 46-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: ... ferritin heavy chain 1; GPX: glutathione peroxidase; GST: glutathione S-transferase; H2O2: hydrogen peroxide; His280: histidine ... Herein, we demonstrate an important role for ßA3/A1-crystallin in RPE. ßA3/A1-crystallin deficiency leads to clathrin-mediated ... We found that ßA3/A1-crystallin binds to phosphatidylinositol transfer protein (PITPß) and that ßA3/A1-crystallin deficiency ...
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
KIT - IBG2Teaching and Seminars - Group Seminar - Past group seminars
Polydisperse alpha B-crystallin - About termini and finding the right groove". 20.05 Thilo Mast (Vertiefer student). "Synthese ... Synthesis of photoswitchable side-chain stapled helical peptides. 22.05. Volodymyr Kubyshkin (TU Berlin). What can proline ... "Analysis of the orientation of fluor-labeled amino acid side chains at various positions. inside peptides via molecular ... "Rekombinante Expression des Transmembransegments de T-Zell Receptors alpha". Papia Sanyal. "Promotion, inhibition and killing ...
DeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
ORF Clones: Search result
Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA.. A8610. ... Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 2, mRNA.. A7467. ... Homo sapiens crystallin alpha A (CRYAA), mRNA.. D0373. NM_013501.3. Cryaa. Acry-1, Crya-1, Crya1, DAcry-1, lop18. Mouse. Mus ... Mus musculus crystallin, alpha A (Cryaa), transcript variant 1, mRNA.. Mm36859. NM_001278570.1. Cryaa. Acry-1, Crya-1, Crya1, ...
cataract | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the ... The amino acid sequences of the a-crystallin A and B chains of the dogfish, Squalus acanthias, have been determined. Comparison ... some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene ... Speculation emerged that these structures were thin filaments with bound alpha crystallin particles, or nucleosomes on DNA, but ...
aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica
Recombination and identification of human alpha B-crystallin.. *. Preston. To recombine the human alpha B-crystallin (αB- ... A Guide to Cloning the Products of Polymerase Chain Reactions. *. Preston. This introduction outlines varied strategies to ... human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, ... Due to the benefit with which the termini of amplified DNAs will be tailor-made by polymerase chain response (PCR), most of the ...
Keith Van Haren, MD's Profile | Stanford Profiles
... and alpha-B-crystallin. In contrast, MS was characterized by IgM autoantibodies targeting myelin basic protein, proteolipid ... We performed a combination of tests: (i) a test for very-long-chain fatty acids (VLCFA) levels, (ii) a D3-C22:0 loading test to ... The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin ... saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have ...
SCOP 1.71: Domain d1u15a : 1u15 A
d1u15a_ a.127.1.1 (A:) Argininosuccinate lyase/delta-crystallin {Domestic duck (Anas platyrhynchos), delta-crystallin} ... Class a: All alpha proteins [46456] (226 folds). *. Fold a.127: L-aspartase-like [48556] (1 superfamily). multihelical, ... Domains from other chains:. (mouse over for more information). d1u15b_, d1u15c_, d1u15d_ ... Protein Argininosuccinate lyase/delta-crystallin [48564] (4 species). *. Species Domestic duck (Anas platyrhynchos), delta- ...
尋找研究成果 - 臺北醫學大學
Cloning of a putative chicken MHC class II alpha chain gene.. Kivela, J., Kung, H. J., Dodgson, J. & Bacon, L., 1月 1 1987, 於: ... Cloning and sequencing of a carp βs-crystallin cDNA. Chang, T. & Chang, W. C., 10月 9 1987, 於: BBA - Gene Structure and ... Extracellular thermostable alpha-amylase from Bacillus stearothermophilus Q8. Lin, H. Y. & Tsay, S. S., 1月 1 1987, 於: Zhonghua ...
Domain IPR003439:ABC transporter-like
Alpha-D-phosphohexomutase, alpha/beta/alpha domain II 76 Domain IPR002068:Alpha crystallin/Hsp20 domain 75 Domain IPR001030: ... alpha chain 2 Domain IPR025959:Winged helix-turn helix domain 2 Family IPR022053:Protein of unknown function DUF3613 2 Domain ... alpha/beta subunit, N-terminal domain 81 Domain IPR001623:DnaJ domain 81 Domain IPR005846:Alpha-D-phosphohexomutase, alpha/beta ... Alpha-D-phosphohexomutase, alpha/beta/alpha domain I 74 Domain IPR008333:Oxidoreductase, FAD-binding domain 74 Domain IPR000064 ...
GSE360 DC VS MAC L MAJOR UP
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
DeCS 2018 - July 31, 2018 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
DeCS 2017 - July 04, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
DeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
DeCS 2017 - December 21, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
IMP: Integrative Multi-species Prediction
crystallin, alpha A. 0.016. Olfr159. olfactory receptor 159. 0.016. Myh8. myosin, heavy polypeptide 8, skeletal muscle, ... hemoglobin Y, beta-like embryonic chain. 0.014. Rbp3. retinol binding protein 3, interstitial. 0.014. ... mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative). 0.010. ... serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10. 0.014. ...
SubunitProteinsCRYABSubunitsCRYAAGeneLensProteinAntibodyMRNAChromosomeDyneinHumanTroponinAttached to the coTissuesMouseLightLensELISA KitGlycoproteinMammalianNeurological diseasesAntibodyGammaSubunit alphaRecombinantPutativeSequenceAntigensGene ExpressionZetaCollagen typeAntibodiesDomainMutantSymbol20kDaBreastStructuralBetaMeshPeptideNuclearDescriptionMajorSpecificAcidActivityStructure
Subunit1
- SLBB domain, 4Fe-4S dicluster domain, RnfC Barrel sandwich hybrid domain, Respiratory-chain NADH dehydrogenase 51 Kd subunit [Interproscan]. (ntu.edu.sg)
Proteins4
- However, fast skeletal myosin light chain 2 followed by troponin T, F-actin-capping and small heat shock proteins showed the greatest phosphorylation change, and therefore they were the most important phosphoproteins underlying LT muscle conversion to DFD meat in the Rubia Gallega breed. (biomedcentral.com)
- A total of 21 proteins were successfully identified by MALDI-TOF-MS analysis, among which some interesting proteins, such as alpha B-crystallin, annexin A2, and stathmin 1, had been reported to involve in cell proliferation and differentiation through different signaling pathways. (big.ac.cn)
- Utilizing a betasheet of the human ubiquitin for paratope creation we obtained binding proteins against tumor necrosis factor (TNF)-alpha. (navigo-proteins.com)
- The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. (cipsm.de)
CRYAB1
- To recombine the human alpha B-crystallin (αB-crystallin) utilizing gene cloning expertise and prokaryotic expression vector and ensure the organic exercise of recombinant human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, setting up the pET-28/CRYAB prokaryotic expression plasmid by restriction enzyme digestion technique, and stably expressing remodeled into the Escherichia coli (E. coli) DH5 alpha. (aprofarm.org)
Subunits3
- Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (expasy.org)
- One of the alpha crystallin subunits. (bvsalud.org)
- the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. (prospecbio.com)
CRYAA1
- Homo sapiens crystallin alpha A (CRYAA), mRNA. (genecopoeia.com)
Gene2
- 8] Moreover, an analysis of antigen receptor H chain gene transcripts of B and plasma cells isolated from s-IBM muscle showed evidence of clonal expansion and variation, isotype switching, and somatic hypermutation, indicative of a local antigen-driven humoral response. (medscape.com)
- A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. (musclegenetable.fr)
Lens1
- The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. (nih.gov)
Protein2
- Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. (elsevier.com)
- Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). (prospecbio.com)
Antibody1
- Various concepts for new formats combining antibody chains or antibody fragments and fusions with other entities have been developed recently. (navigo-proteins.com)
MRNA1
- Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA. (genecopoeia.com)
Chromosome1
- A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12. (musclegenetable.fr)
Dynein1
- dynein axonemal heavy chain 17 [Sou. (gsea-msigdb.org)
Human2
- Recombination and identification of human alpha B-crystallin. (aprofarm.org)
- Accumulation of amyloid in breast cancer is a well-known phenomenon, but only immunoglobulin light-chain amyloidosis (AL) or transthyretin (TTR) amyloid had been detected in human breast tumor samples previously. (inyushinlab.org)
Troponin1
- Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. (musclegenetable.fr)
Attached to the co1
- These dyes differ in the number of polyethylene glycol (PEG) chains attached to the core structure which is either a perylene derivate or a terrylene derivate. (cipsm.de)
Tissues2
- Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. (prospecbio.com)
- The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin and blood. (stanford.edu)
Mouse2
- Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. (glembotskilab.org)
- Mouse IgG2b heavy chains and κ light chain. (prospecbio.com)
Light3
- Hydrocarbon chain order also correlated with light scattering intensity by sphingomyelin LUVs. (nih.gov)
- Light scattered by LUVs composed of sphingomyelin (1-30 mg ml(-1)) was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. (nih.gov)
- Increased lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid compositional changes can influence membrane light scattering properties. (nih.gov)
Lens8
- Genes associated with the development of lens include crystallin genes. (nih.gov)
- From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. (nih.gov)
- alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. (nih.gov)
- The extent of normal lens lipid hydrocarbon chain order increased with age from the equatorial and cortical regions to the nucleus. (arvojournals.org)
- Increased lipid oxidation and hydrocarbon chain disorder correlate with increased lens nuclear opacity in the in vivo HBO model. (arvojournals.org)
- Since it has been shown that lens injury may promote nerve regeneration, crystallin has been an area of neural research. (absoluteastronomy.com)
- It is becoming increasingly clear that crystallins may have several metabolic and regulatory functions, both within the lens and in other parts of the body. (absoluteastronomy.com)
- Yamada T、Tsuchida S. The Hirosaki small-eye rat: A novel recessive model animal of lens and retinal degeneration with loss of A3/A1-crystallin. (nichiyaku.ac.jp)
ELISA Kit2
- Description: A sandwich ELISA kit for detection of Fibrinogen Alpha from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
- Should the Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (wildpalm.net)
Glycoprotein1
- We have examined the cleavage of ribonuclease A and the related N-linked glycoprotein ribonuclease B, and the O-linked glycoprotein alpha crystallin A chain, using MALDI-TOF and LC-ESI-MS to identify the peptide products. (researchgate.net)
Mammalian1
- In addition, fish γM-crystallins do not conserve the paired tryptophan residues found in each domain in mammalian γ-crystallins and in the related β-crystallins. (nih.gov)
Neurological diseases1
- Crystallins are divided into B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy. (neobiotechnologies.com)
Antibody5
- Formalin-fixed, paraffin-embedded human Breast stained with Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
- Western Blot Analysis of HeLa cell lysate using Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
- SDS-PAGE Analysis Purified Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibrinogen Alpha (FGa) in Plasma. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fibrinogen Alpha (FGa) in samples from Plasma with no significant corss-reactivity with analogues from other species. (scalegen.com)
Gamma3
- Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (uams.edu)
- crystallin beta-gamma domain containi. (gsea-msigdb.org)
- Alpha, beta, and gamma tubulins have all been used as loading controls. (neobiolab.com)
Subunit alpha1
- Description: A competitive ELISA for quantitative measurement of Human Voltage dependent N type calcium channel subunit Alpha 1B(CACNA1B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (wildpalm.net)
Recombinant10
- IFI30 Human Recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids (58-232) and having a molecular mass of 22.5 kDa. (neobiolab.com)
- IFNA1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids (24-189) and having a molecular mass of 19.5 kDa. (neobiolab.com)
- Interferon-alpha 1a Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19.4 kDa.The Interferon-alpha 1a contains Valine residue at position 114.The IFN-a 1a is purified by proprietary chromatographic techniques. (neobiolab.com)
- Interferon-a 2b Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19269 Dalton. (neobiolab.com)
- Interferon-beta 1a Human Recombinant produced in CHO (Chinese Hamster Ovarian) cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton.IFN-beta1a is purified by proprietary chromatographic techniques. (neobiolab.com)
- Interferon beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human Interferon beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. (neobiolab.com)
- Description: TDG Human Recombinant produced in E. coli is a single polypeptide chain containing 433 amino acids (1-410) and having a molecular mass of 48.4 kDa. (gentaur.se)
- BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.BMP-5 is purified by proprietary chromatographic techniques. (kendallscientific.com)
- BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, Polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. (kendallscientific.com)
- BMPR1A Human Recombinant produced in HEK-293 cells is a single, glycosylated, polypeptide chain containing 369 amino acids with a molecular weight of43.7 kDa thoµgh on SDS-PAGE migrates at about 50 kDa due to the glycosilation.The BMPR1A is purified by proprietary chromatographic techniques. (kendallscientific.com)
Putative1
- Cloning of a putative chicken MHC class II alpha chain gene. (elsevier.com)
Sequence1
- The DNA sequence encoding the human BMP-2 signal peptide and propeptide (1~282 amino acid) fused to the human rhBMP-7 mature chain (293~431 amino acid) was expressed in a Chinese hamster ovary cell line. (kendallscientific.com)
Antigens2
- Specifically, this diagnostic approach exploits M. tuberculosis secreted latency specific antigens, such as alpha-crystallin, in the blood or urine of patients. (nih.gov)
- These antigens have a heavy chain and an associated light chain. (medscape.com)
Gene Expression1
- Gene expression changes induced by short-term tumor necrosis factor-alpha (TNF-α) treatment were largely sustained in the FLS exposed to chronic inflammation. (surfaceyourrealself.com)
Zeta1
- crystallin zeta like 1 [Source:HGNC Sy. (gsea-msigdb.org)
Collagen type3
- collagen type XXII alpha 1 chain [Sou. (gsea-msigdb.org)
- collagen type IX alpha 3 chain [Sourc. (gsea-msigdb.org)
- collagen type XX alpha 1 chain [Source. (gsea-msigdb.org)
Antibodies1
- we performed immunohistochemistry on sectioned Myf-5 and MyoD mutant embryos with antibodies reactive with desmin , nestin, myosin heavy chain, sarcomeric actin, Myf-5, MyoD and myogenin. (labome.org)
Domain1
- C.A. Barnes, Y. Shen, J. Ying, and A. Bax: Modulating the Stiffness of the Myosin VI Single alpha-Helical Domain. (nih.gov)
Mutant1
- Mutant (P182L) but not wild-type HSPB1 led to the formation of insoluble intracellular aggregates and to the sequestration in the cytoplasm of selective cellular components, including neurofilament middle chain subunit (NF-M) and p150 dynactin. (lookformedical.com)
Symbol1
- alpha fetoprotein [Source:HGNC Symbol. (gsea-msigdb.org)
20kDa1
- The Pegylated IFN-a 2b is produced by attaching a 20kDa mPEG-aldehyde to the N-terminal IFN alpha-2b. (neobiolab.com)
Breast2
- 10. Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR. (nih.gov)
- 18. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. (nih.gov)
Structural2
- An alpha and beta tubulin heterodimer is the basic structural unit of microtubules. (neobiolab.com)
- S.C. Chiliveri, J.M. Louis, and A. Bax: Concentration-dependent structural transition of the HIV-1 gp41 MPER peptide into alpha-helical trimers. (nih.gov)
Beta2
- The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. (neobiolab.com)
- TCR beta-chain does not appear to interact directly with beta2M. (cusabio.com)
Mesh1
- Crystallins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Peptide1
- A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of. (absoluteastronomy.com)
Nuclear1
- spectrin repeat containing nuclear en. (gsea-msigdb.org)
Description3
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibrinogen Alpha (FGa) in samples from plasma. (scalegen.com)
- Description: A competitive ELISA for quantitative measurement of Mouse fibrinogen alpha chain(FGA) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) in samples from tissue homogenates, cell lysates or other biological fluids. (wildpalm.net)
Major1
- This graph shows the total number of publications written about "Crystallins" by people in UAMS Profiles by year, and whether "Crystallins" was a major or minor topic of these publications. (uams.edu)
Specific1
- A specific phosphorylation regulates the protective role of αA-crystallin in diabetes. (vanderbilt.edu)
Acid2
- The linkage of the glycosidic group to the asparagine side-chain in ribonuclease B was found not to be cleaved by brief microwave treatment in 12.5 % acetic acid. (researchgate.net)
- The distribution of the heterogeneous carbohydrate side chain in the glycopeptide products of acid cleavage was compared to that of the glycopeptide products of tryptic digestion. (researchgate.net)
Activity1
- Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (nih.gov)
Structure1
- Solution Structure of the alpha-crystallin do. (nih.gov)