AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Crystallinsalpha-CrystallinsLens, Crystallinebeta-Crystallin B Chainbeta-Crystallin A Chaingamma-Crystallinsbeta-Crystallinsalpha-Crystallin A Chainalpha-Crystallin B Chaindelta-CrystallinsCataractMolecular Sequence DataPolymerase Chain Reactionalpha 1-AntitrypsinAmino Acid SequenceBase SequenceArgininosuccinate LyaseReceptors, Adrenergic, alphaHypoxia-Inducible Factor 1, alpha SubunitCattleElectrophoresis, Polyacrylamide GelProtein BindingRecombinant ProteinsProto-Oncogene Proteins c-mafReverse Transcriptase Polymerase Chain ReactionMutationNative Polyacrylamide Gel ElectrophoresisModels, MolecularBinding Sitesalpha7 Nicotinic Acetylcholine ReceptorImmunoglobulin Light ChainsRNA, MessengerCloning, MolecularProtein ConformationImmunoglobulin Heavy Chains
Crystallins
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.
alpha-Crystallins
A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Lens, Crystalline
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
beta-Crystallin B Chain
The basic subunit of beta-crystallins.
beta-Crystallin A Chain
The acidic subunit of beta-crystallins.
gamma-Crystallins
A subclass of crystallins that found in the lens (LENS, CRYSTALLINE) of VERTEBRATES. Gamma-crystallins are similar in structure to BETA-CRYSTALLINS in that they both form into a Greek key-like structure. They are composed of monomeric subunits.
beta-Crystallins
A class of crystallins that provides refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Beta-crystallins are similar in structure to GAMMA-CRYSTALLINS in that they both contain Greek key motifs. Beta-crystallins exist as oligomers formed from acidic (BETA-CRYSTALLIN A CHAIN) and basic (BETA-CRYSTALLIN B CHAIN) subunits.
alpha-Crystallin A Chain
One of the subunits of alpha-crystallins. Unlike ALPHA-CRYSTALLIN B CHAIN the expression of ALPHA-CRYSTALLIN A CHAIN is limited primarily to the lens (LENS, CRYSTALLINE).
alpha-Crystallin B Chain
One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.
delta-Crystallins
A subclass of crystallins found in the lens (LENS, CRYSTALLINE) in BIRDS and REPTILES. They are inactive forms of the enzyme argininosuccinate lyase.
Cataract
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
alpha 1-Antitrypsin
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Argininosuccinate Lyase
An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Proto-Oncogene Proteins c-maf
Maf proto-oncogene protein is the major cellular homolog of the V-MAF ONCOGENE PROTEIN. It was the first of the mammalian MAF TRANSCRIPTION FACTORS identified, and it is induced in activated T-LYMPHOCYTES and regulates GENETIC TRANSCRIPTION of INTERLEUKIN-4. c-maf is frequently translocated to an immunoglobulin locus in MULTIPLE MYELOMA.
Reverse Transcriptase Polymerase Chain Reaction
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Native Polyacrylamide Gel Electrophoresis
Polyacrylamide gel electrophoresis under conditions in which the components, such as PROTEINS, being separated can remain in their naturally folded state.
Models, Molecular
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.
alpha7 Nicotinic Acetylcholine Receptor
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Immunoglobulin Light Chains
Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Immunoglobulin Heavy Chains
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.

Decreased heat stability and increased chaperone requirement of modified human betaB1-crystallins. (1/136)

PURPOSE: To determine how deamidation and partial loss of the N- and C-terminal extensions alter the heat stability of betaB1-crystallin. METHODS: Human lens betaB1, a deamidated betaB1, Q204E, and alphaA-crystallins were expressed. Truncated betaB1 was generated by proteolytic removal of part of its terminal extensions. The aggregation and precipitation of these proteins due to heating was monitored by circular dichroism and light scattering. The effect of heat on the stability of both monomers and oligomers was investigated. The flexibility of the extensions in wild type and deamidated betaB1 was assessed by 1H NMR spectroscopy. RESULTS: With heat, deamidated betaB1 precipitated more readily than wild type betaB1. Similar effects were obtained for either monomers or oligomers. Flexibility of the N-terminal extension in deamidated betaB1 was significantly reduced compared to the wild type protein. Truncation of the extensions further increased the rate of heat-induced precipitation of deamidated betaB1. The presence of the molecular chaperone, alphaA-crystallin, prevented precipitation of modified betaB1s. More alphaA was needed to chaperone the truncated and deamidated betaB1 than deamidated betaB1 or truncated betaB1. CONCLUSIONS: Deamidation and truncation of betaB1 led to destabilization of the protein and decreased stability to heat. Decreased stability of lens crystallins may contribute to their insolubilization and cataract formation.  (+info)

Quantification of chick lens alphaA- and delta-crystallins in experimentally induced ametropia. (2/136)

PURPOSE: The role of the lens in experimentally induced ametropia is not known. A recent study of the chick lens demonstrated optical quality deterioration with the induction of refractive errors, without alteration in lens morphology, size or shape. A change in lens gradient of refractive index (which is dependent on alpha-, beta-, and delta-crystallin concentration and arrangement), could underlie this observation. The purpose of this work was to quantify the concentrations of alphaA- and delta-crystallin in lenses from chick eyes with induced high myopia or hyperopia. METHODS: White Leghorn chicks were unilaterally fitted on the day of hatching either with translucent plastic goggles to induce form-deprivation myopia (n=21) or with +15 D defocus goggles to induce hyperopia (n=14). The ungoggled contralateral eyes were used as controls. The chicks were refracted twice, once on the day of hatching and again seven days later, using streak retinoscopy. On day 7 chicks were sacrificed, lenses decapsulated, and soluble proteins were isolated. Western blot assays were optimized and used to assess crystallin concentration. RESULTS: Analysis revealed no significant difference in alphaA- or delta-crystallin concentration in lenses from eyes induced with form-deprivation myopia and hyperopia as compared to their respective control eyes. Analysis of the difference in medians of delta-crystallin between the control and treated groups of the myopia and hyperopia experiments revealed significance (p=0.030). CONCLUSIONS: This study suggests that with the induction of ametropia, the increased lens spherical aberration previously noted is not due to a change in the absolute concentration of lens alphaA- or delta-crystallin. However, results suggest that the myopic and hyperopic treatments had different effects on lens delta-crystallin concentration. Further investigation is necessary to expand the current knowledge of the role played by the lens in experimental ametropia.  (+info)

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. (3/136)

BACKGROUND: One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated. In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alpha A and alpha B are normally expressed at high levels. The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alpha A- and alpha B-crystallin genes (alpha A/BKO). METHODS: Lenses from 129SvEvTac mice and alpha A/BKO mice were examined by standard scanning electron microscopy and confocal microscopy methodologies. RESULTS: Equatorial and axial (sagittal) dimensions of lenses for alpha A/BKO mice were significantly smaller than age-matched wild type lenses. No posterior sutures or fiber cells extending to the posterior capsule of the lens were found in alpha A/BKO lenses. Ectopical nucleic acid staining was observed in the posterior subcapsular region of 5 wk and anterior subcapsular cortex of 54 wk alpha A/BKO lenses. Gross morphological differences were also observed in the equatorial/bow, posterior and anterior regions of lenses from alpha A/BKO mice as compared to wild mice. CONCLUSION: These results indicated that both alpha A- and alpha B-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation.  (+info)

Reduced survival of lens epithelial cells in the alphaA-crystallin-knockout mouse. (4/136)

alphaA-Crystallin (alphaA) is a molecular chaperone expressed preferentially in the lens. alphaA transcripts are first detected during the early stages of lens development and its synthesis continues as the lens grows throughout life. alphaA(-/-) mouse lenses are smaller than controls, and lens epithelial cells derived from these mice have diminished growth in culture. In the current work, we tested the hypothesis thatalphaA prevents cell death at a specific stage of the cell cycle in vivo. Seven-day-old 129Sv (wild-type) and alphaA(-/-) mice were injected with 5-bromo-2'-deoxyuridine (BrdU) to label newly synthesized DNA in proliferating cells. To follow the fate of the labeled cells, wholemounts of the capsule epithelial explants were made at successive times after the BrdU pulse, and the labeling index was determined. Immunofluorescence and confocal microscopy showed that both wild-type and alphaA(-/-) cells had a 3-hour labeling index of 4.5% in the central region of the wholemount, indicating that the number of cells in S phase was the same. Twenty-four hours after the pulse, individual cells labeled with BrdU had divided and BrdU-labeled cells were detected in pairs. The 24-hour labeling index in the wild-type lens was 8.6%, but in the alphaA(-/-) lens it was significantly lower, suggesting that some of the cells failed to divide and/or that the daughter cells died during mitosis. TUNEL labeling was rarely detected in the wild-type lens, but was significant and always detected in pairs in the alphaA(-/-) wholemounts. Dual labeling with TUNEL and BrdU also suggested that the labeled cells were dying in pairs in the alphaA(-/-) lens epithelium. Immunolabeling of wholemounts with beta-tubulin antibodies indicated that the anaphase spindle in a significant proportion of alphaA(-/-) cells was not well organized. Examination of the cellular distribution of alphaA in cultured lens epithelial cells showed that it was concentrated in the intercellular microtubules of cells undergoing cytokinesis. These data suggest that alphaA expression in vivo protects against cell death during mitosis in the lens epithelium, and the smaller size of the alphaA(-/-) lens may be due to a decrease in the net production of epithelial cells.  (+info)

Alteration of protein-protein interactions of congenital cataract crystallin mutants. (5/136)

PURPOSE: A recent study demonstrated the presence of protein-protein interactions among lens crystallins in a mammalian cell two-hybrid system assay and speculated about the significance of these interactions for protein solubility and lens transparency. The current study extends those findings to the following crystallin genes involved in some congenital cataracts: CRYAA (R116C), CRYAB (R120G), and CRYGC (T5P). METHODS: A mammalian two-hybrid system was used to assay the protein-protein interactions. Congenital cataract crystallin genes were cloned and fused into the two-hybrid system vectors (target and prey proteins). Together, with the third vector containing a reporter gene, chloramphenicol acetyltransferase (CAT), they were cotransfected into human HeLa cells. The presence of protein-protein interactions and the strength of these interactions were assayed by CAT ELISA. RESULTS: The pattern of changes in protein-protein interactions of those congenital cataract gene products with the three major crystallins, alphaA- or alphaB-, betaB2-, and gammaC-crystallins, differed. For the T5P gammaC-crystallin, most of the interactions were decreased; for the R116C alphaA-crystallin, the interactions with betaB2- and gammaC-crystallin decreased and those with alphaB-crystallin and heat-shock protein (Hsp)27 increased; and for the R120G alphaB-crystallin, the interactions with alphaA- and alphaB-crystallin decreased, but those with betaB2- and gammaC-crystallin increased slightly. An attempt was made to interpret the results on the basis of conformational change and disruption of dimeric interaction involving beta-strands. CONCLUSIONS: The results clearly indicate that crystallin mutations involved in congenital cataracts altered protein-protein interactions, which may contribute to decreased protein solubility and formation of cataract.  (+info)

Immunological detection of D-beta-aspartate-containing protein in lens-derived cell lines. (6/136)

PURPOSE: Although the presence of biologically uncommon D-beta-aspartate (D-beta-Asp) in lens protein is thought to be related to aging, we recently found this isomer in lens alphaA-crystallin from human newborns. The objective of this study was to examine whether D-beta-Asp occurs in protein from lens-derived cell lines. METHODS: We examined the expression of D-beta-Asp-containing protein in the lens-derived cell lines alphaTN4-1 and N/N1003A, by western blot and immunoprecipitation analysis using a polyclonal antibody against Gly-Leu-D-beta-Asp-Ala-Thr-Gly-Leu-D-beta-Asp-Ala-Thr-Gly-Leu-D-beta-Asp-Ala-Thr (peptide 3R), which corresponds to three repeats of positions 149-153 in human alphaA-crystallin. The anti-peptide 3R antibody, prepared in a previous study, is a useful tool for investigating D-beta-Asp-containing peptides. RESULTS: Western immunoblot and immunoprecipitation analysis showed that a 50 kDa protein in N/N1003A cells was strongly immunoreactive with the anti-peptide 3R antibody. Antibodies against alphaA- and alphaB-crystallin also stained this protein. On the other hand, the alphaTN4-1 cell line only expressed proteins of about 20 kDa, which also reacted to antibodies against alphaA-crystallin and alphaB-crystallin. CONCLUSIONS: The results indicate that the N/N1003A cell line expressed a 50 kDa D-beta-Asp-containing protein, which may share a common amino acid sequence with alphaA- and alphaB-crystallin.  (+info)

Induction of the differentiation of lentoids from primate embryonic stem cells. (7/136)

PURPOSE: To produce lens cells from primate embryonic stem (ES) cells in a reproducible, controlled manner. METHODS: Cynomologus monkey ES cells were induced to differentiate by stromal cell-derived inducing activity (SDIA). The lentoids produced by this treatment were processed for immunohistochemical and immunoblotting analysis. The effect of varying the concentration of fibroblast growth factor (FGF)-2 and the density of the ES colonies plated during the differentiation process were also examined. RESULTS: After a 2- to 3-week induction period, lentoids were produced by a subpopulation of ES colonies. Western blot analysis and immunohistochemistry revealed that these lentoids expressed alphaA-crystallin and Pax6. The number of lentoids resulting from treatment increased with increasing FGF-2 concentration and plated colony density. CONCLUSIONS: The differentiation of primate ES cells into lentoids can be achieved by treatment with SIDA. ES cells can be used to facilitate a greater understanding of the mechanisms functioning in differentiation in vivo and in vitro.  (+info)

Pathogenesis of axonal dystrophy and demyelination in alphaA-crystallin-expressing transgenic mice. (8/136)

We recently described a transgenic mouse strain overexpressing hamster alphaA-crystallin, a small heat shock protein, under direction of the hamster vimentin promoter. As a result myelin was degraded and axonal dystrophy in both central nervous system (especially spinal cord) and peripheral nervous system occurred. Homozygous transgenic mice developed hind limb paralysis after 8 weeks of age and displayed progressive loss of myelin and axonal dystrophy in both the central and peripheral nervous system with ongoing age. Pathologically the phenotype resembled, to a certain extent, neuroaxonal dystrophy. The biochemical findings presented in this paper (activity of the enzymes superoxide dismutase, catalase and transglutamase, myelin protein zero expression levels and blood sugar levels) confirm this pathology and exclude other putative pathologies like Amyothrophic Lateral Sclerosis and Hereditary Motor and Sensory Neuropathy. Consequently, an excessive cytoplasmic accumulation of the transgenic protein or a disturbance of the normal metabolism are considered to cause the observed neuropathology. Therefore, extra-ocular alphaA-crystallin-expressing transgenic mice may serve as a useful animal model to study neuroaxonal dystrophy.  (+info)

The effect of dextran on subunit exchange of αA-crystallin by A. Ghahghaei, A. Rekas et al.The effect of dextran on subunit exchange of αA-crystallin by A. Ghahghaei, A. Rekas et al.
α-Crystallin, a member of small heat shock protein (sHsp) family, is comprised of αA and αB subunits and acts as a molecular chaperone by interacting with unfolding proteins to prevent their aggregation. The αA-crystallin homopolymer consists of 30-40 subunits that are undergoing dynamic exchange. α-Crystallin and αA-crystallin are poorer chaperones in the presence of the crowding agent, dextran. Using fluorescence resonance energy transfer, it is shown that the αAcrystallin subunit exchange rate strongly increased with temperature. Binding of reduced ovotransferrin to αA-crystallin markedly decreases the rate of subunit exchange, as does the presence of dextran. In addition, in the presence of dextran the effect of reduced ovotransferrin on decreasing the rate of subunit exchange of αA-crystallin is stronger than in the absence of dextran. Under the conditions of molecular crowding, the αA-crystallin subunit exchange rate is not temperature-dependent. The exchange rate of αA-crystallin
http://ro.uow.edu.au/scipapers/131/
CSIR - Centre for Cellular & Molecular Biology
The cataract-causing mutation G98R in human aA-crystallin leads to folding defects and loss of chaperone activity Molecular Vision, 12, 1372-9 2006 ...
http://www.ccmb.res.in/index.php?view=publications&mid=128&id=68&grpid=5
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Alpha-Crystallins Regulate DNA Damage Pathway to Prevent Stress-Induced Apoptosis of Human Lens Epithelial Cells | IOVS | ARVO...Alpha-Crystallins Regulate DNA Damage Pathway to Prevent Stress-Induced Apoptosis of Human Lens Epithelial Cells | IOVS | ARVO...
Purpose: : In our previous studies, we have demonstrated that alpha-crystallins can negatively regulate stress-induced apoptosis through suppression of the ERK-mediated pathway and activation of the AKT signaling pathway. In the present study, we present evidence to show that alpha-crystallins can regulate the ATR-p53 pathway to prevent UVA-induced apoptosis. Methods: : UVA was used to irradiate human lens epithelial cells stably expressing vector, alphaA, and alphaB. Western blot analysis was used for detection of ATR, CHK1/2 and p53 activation. Reporter gene activity assay was used to explore the transactivity of p53. Hoechst staining was used for apoptosis assay. Results: : Human lens epithelial cells expressing either alphaA- or alphaB-crystallin are substantially resistant to UVA-induced apoptosis. UVA-induces activation of ATR and CHK1/2 kinases to activate p53 in vector-transfected cells. However, in alphaA- or alphaB-crystallin-transfected cells, activation of ATR, CHK1/2 kinases and p53 ...
http://iovs.arvojournals.org/article.aspx?articleid=2367547
Alpha-crystallin elisa and antibodyAlpha-crystallin elisa and antibody
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Ed to contribute to its chaperone-like activity [57], while the N-terminal domains | Caspase1-Inhibitors caspase1inhibitor.com
Ed to contribute to its chaperone-like activity , while the N-terminal domains contain phosphorylation sites that are the targets of various protein kinases .
http://www.caspase1inhibitor.com/2017/09/11/ed-to-contribute-to-its-chaperone-like-activity-57-while-the-n-terminal-domains/
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Regulation of Signaling Pathways by A-Crystallin: A Possible Role for A-Crystallin Association With 6 Integrin Complexes |...Regulation of Signaling Pathways by A-Crystallin: A Possible Role for A-Crystallin Association With 6 Integrin Complexes |...
Abstract: : Purpose: To examine the dependence of lens cell signaling pathways on αA-crystallin and determine whether this novel function for αA-crystallin may be related to its association with α6 integrin. Methods: Mouse lenses obtained from wild type or αA knockout lenses were microdissected into epithelial and cortical fiber fractions. Immunoblot analysis with antibodies to activated forms of specific cell signaling proteins (Src, p38, ERK and JNK) was performed. Analysis of these cell signaling pathways was also performed with control mouse lens cultures and those transfected with wild type αA-crystallin or the R116C αA-crystallin mutant. The association of αA-crystallin with α6 integrin in mouse epithelial and cortical fiber fractions was analyzed by immunoprecipitation with antibodies to α6 integrin followed by immunoblotting for αA-crystallin. Similar studies were performed with chicken embryo lenses microdissected into central and equatorial epithelia, cortical and nuclear ...
https://iovs.arvojournals.org/article.aspx?articleid=2403298
Burgio, Mol Vis 2001; 7:228-233.Burgio, Mol Vis 2001; 7:228-233.
Discussion. The data presented here indicate that heat incubation produces structural and functional changes in renatured a-, aA-, and aB-crystallins as well as in the native a-crystallin. The chain like structures observed in the 65 °C transmission electron micrographs may indicate the particles formed after heat incubation have a greater propensity to interact with each other than the native particles. These chains could also be artifacts of the negative staining process, however.. There are major differences in the heat-induced secondary structural transitions that separate the native a-crystallin from the other a-crystallins. Renatured a-crystallin exhibits more severe structural changes that are observable at lower incubation temperatures than the native a-crystallin. The effects of heat incubation on chaperone-like activity are also completely opposite, with the native a-crystallin samples showing an improvement and renatured a-crystallin samples showing a progressive decline in activity ...
http://www.molvis.org/molvis/v7/a32/
CRYAA2 - Alpha-crystallin A2 chain - Homo sapiens (Human) - CRYAA2 gene & proteinCRYAA2 - Alpha-crystallin A2 chain - Homo sapiens (Human) - CRYAA2 gene & protein
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
https://www.uniprot.org/uniprot/A0A140G945
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Thermal and acid denaturation of bovine lens alpha-crystallin | Drug Delivery TechnologyThermal and acid denaturation of bovine lens alpha-crystallin | Drug Delivery Technology
The chaperone-like protein alpha-crystallin is a approximately 35 subunit hetero-oligomer consisting of alphaA and alphaB subunits in a 3:1 molar ratio and has the function of maintaining eye lens transparency. We studied the thermal denaturation of alpha-crystallin by differential scanning calorimetry (DSC), circular dichroism (CD), and dynamic light scattering (DLS) as a function of pH. Our results show that between pH 7 and 10 the protein undergoes a reversible thermal transition. However, the thermodynamic parameters obtained by DSC are inconsistent with the complete denaturation of an oligomeric protein of the size of alpha-crystallin. Accordingly, the CD data suggest the presence of extensive residual secondary structure above the transition temperature. Within the pH range from 4 to 7 the increased aggregation propensity around the isoelectric point (pI approximately 6) precludes observation of a thermal transition. As pH decreases below 4 the protein undergoes a substantial unfolding. ...
http://drugdeliverytechnology.leidenuniv.nl/publications/3269
Fluorescence study of the effects of aging and diabetes mellitus on human lens alpha-crystallin. - Semantic ScholarFluorescence study of the effects of aging and diabetes mellitus on human lens alpha-crystallin. - Semantic Scholar
Human alpha-crystallins were separated from fetal, young, senile nondiabetic and diabetic lenses. The effects of aging and diabetes mellitus were studied by fluorescence measurements, including emission maximum, quantum yield and polarization, using both intrinsic probes (tryptophan and non-tryptophan) and extrinsic probes [4-(N-iodoacetoxy)N-methylamino-7-nitrobenz-2-oxa-1,3-diazole (IANBD) and 6-(p-toluidinyl)naphthalene-2-sulfonate (TNS)]. Results indicate that diabetic effects (glycation and aggregation) give fluorescence change to a far greater extent than that of aging. This was demonstrated by a large decrease in tryptophan quantum yield and an increase in non-tryptophan quantum yield, and also by a decrease in polarization of non-tryptophan. The sulfhydryl (SH)-specific probe IANBD shows a blue-shift in emission maximum, a decrease in intensity and an increase in polarization. The hydrophobic probe TNS shows a decrease in both intensity and polarization. These results suggest that tryptophan
https://www.semanticscholar.org/paper/Fluorescence-study-of-the-effects-of-aging-and-dia-Liang/9c963224479bfafdcd5777d9ed0f0e8e761112d0
alphaB-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progressionalphaB-Crystallin regulates expansion of CD11b(+)Gr-1(+) immature myeloid cells during tumor progression
The molecular chaperone alphaB-crystallin has emerged as a target for cancer therapy due to its expression in human tumors and its role in regulating tumor angiogenesis. alphaB-crystallin also reduces neuroinflammation, but its role in other inflammatory conditions has not been investigated. Here, we examined whether alphaB-crystallin regulates inflammation associated with tumors and ischemia. We found that CD45(+) leukocyte infiltration is 3-fold increased in tumors and ischemic myocardium in alphaB-crystallin-deficient mice. Notably, alphaB-crystallin is prominently expressed in CD11b(+) Gr-1(+) immature myeloid cells (IMCs), known as regulators of angiogenesis and immune responses, while lymphocytes and mature granulocytes show low alphaB-crystallin expression. alphaB-Crystallin deficiency results in a 3-fold higher accumulation of CD11b(+) Gr-1(+) IMCs in tumors and a significant rise in CD11b(+) Gr-1(+) IMCs in spleen and bone marrow. Similarly, we noted a 2-fold increase in CD11b(+) ...
http://umu.diva-portal.org/smash/record.jsf?pid=diva2:865888
ZFIN Publication: Wu et al., 2018ZFIN Publication: Wu et al., 2018
Mutations in the small heat shock proteins α-crystallins have been linked to autosomal dominant cataracts in humans. Extensive studies in vitro have revealed a spectrum of alterations to the structure and function of these proteins including shifts in the size of the oligomer, modulation of subunit exchange and modification of their affinity to client proteins. Although mouse models of these mutants were instrumental in identifying changes in cellular proliferation and lens development, a direct comparative analysis of their effects on lens proteostasis has not been performed. Here, we have transgenically expressed cataract-linked mutants of αA- and αB-crystallin in the zebrafish lens to dissect the underlying molecular changes that contribute to the loss of lens optical properties. Zebrafish lines expressing these mutants displayed a range of morphological lens defects. Phenotype penetrance and severity were dependent on the mutation even in fish lines lacking endogenous α-crystallin. The ...
http://zfin.org/ZDB-PUB-181127-84
HSP27 Antibody Staining Protocol for Immunohistochemistry
Description: The heat-shock proteins (HSPs) belong to a larger group of polypeptides, the stress proteins, that are induced in various combinations in response to environmental challenges and developmental transitions. Synthesis of the small (27-kD) HSP has been shown to be correlated with the acquisition of thermotolerance. The deduced 199-amino acid HSP27 protein shows sequence similarity to mammalian alpha-crystallins. Approximately 20% of its residues are susceptible to phosphorylation. The HSP27 gene, which is mapped to 7q11.23 and has 3 exons1, produced a 2.2-kb transcript in an in vitro transcription assay. Decreasing ROS in cells expressing mutant huntingtin, HSP27 protects cells against oxidative stress2. In other words, HSP27 is a suppressor of polyglutamine (polyQ)-mediated cell death3. Furthermore, MAPKAPK5 is a major stress-activated kinase that can phosphorylate HSP27 in vitro.. Primary Antibody. ...
http://www.ihcworld.com/_protocols/antibody_protocols/hsp27_ihcworld.htm
Hereditary Cataract (HSF4)Hereditary Cataract (HSF4)
Der Hereditäre Katarakt ist eine vererbbare Linsentrübung, auch als Grauer Star bezeichnet. Bei manchen Hunderassen kann sie schon in der Jugend auftreten.
https://shop.labogen.com/en/genetic-test-order/dog/boston-terrier/1972/hereditary-cataract-hsf4?c=453
Import Data And Price Of FOLDABLE INTRA OCULAR LENS | www.eximpulse.comImport Data And Price Of FOLDABLE INTRA OCULAR LENS | www.eximpulse.com
Import Data And Price Of FOLDABLE INTRA OCULAR LENS , www.eximpulse.com Eximpulse Services will provide you the latest and relevant market intelligence reports of FOLDABLE INTRA OCULAR LENS Import Data. You can find live data of maximum number of ports of India which is based on updated shipment data of Indian Customs. Only previous two days data will be seen on website. You can use this FOLDABLE INTRA OCULAR LENS import data for multiple kinds of analysis; lets say Import price, Quantity, market scenarios, Price trends, Duty optimization and many more. You can go through some of the sample shipment records for FOLDABLE INTRA OCULAR LENS import data mentioned above. Here on Eximpulse Services you will get all kind of free sample as well as detailed reports of Export/ Import data as per your requirement. To get in touch for any kind of enquiry related to free sample or detailed report contact on +91-120-408-4957, +91-120-408-4958,+91-120-428-4019.. Data post 2012 as per Notification No.18/2012 - ...
https://www.eximpulse.com/import-product-FOLDABLE-INTRA-OCULAR-LENS.htm
CRYAA - Alpha-crystallin A chain - Cavia porcellus (Guinea pig) - CRYAA gene & proteinCRYAA - Alpha-crystallin A chain - Cavia porcellus (Guinea pig) - CRYAA gene & protein
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity).
http://www.uniprot.org/uniprot/P68281
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P. de Ronsard; Oeuvres Poétiques: Index Alphabétique (French Edition) Vaganay, Hugues » holypet.ruP. de Ronsard; Oeuvres Poétiques: Index Alphabétique (French Edition) Vaganay, Hugues » holypet.ru
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Protective mechanisms against oxidative stress in retinal pathogenesis :: University of Southern California Dissertations and...
Ample evidence suggests that oxidative stress and other external stressors contribute to retinal and retinal pigment epithelium (RPE) pathology, as implicated in diseases like age-related macular degeneration. Therefore the understanding of cellular protection against these insults is of therapeutic importance. We adapted two approaches for studying the mechanisms of macular and retinal degeneration. In one, the contribution and significance of these pathologic processes was investigated by use of cultured human and mouse RPE. In the in vivo counterpart studies, we assessed the importance of alpha-crystallins in the retina (and RPE) in models using knockout mice and cobalt chloride injections. In addition to alpha-crystallins, we looked at other oxidative stress protectants of the cell and examined the redox regulation and antioxidant functions mediated by hepatocyte growth factor (HGF). These studies have greatly contributed to the elucidation of the pathways involved in retinal dysfunction and ...
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll127/id/327478/rec/10
Rubisco activase - Rubiscos catalytic chaperoneRubisco activase - Rubiscos catalytic chaperone
The current status of research on the structure, regulation, mechanism and importance of Rubisco activase is reviewed. The activase is now recognized to be a member of the AAA(+) family, whose members participate in macromolecular complexes that perform diverse chaperone-like functions. The conserve …
https://pubmed.ncbi.nlm.nih.gov/16245090/?dopt=Abstract
Taxonomy - GRIN-Global Web v 1.9.9.2
Demilly, D. et al. Liste alphabétique des principales espèces de plantes cultivées et de mauvaises herbes. Noms latins et noms français, ed. 7. 2001 (L Noms French ed7 ...
https://npgsweb.ars-grin.gov/gringlobal/taxonomydetail.aspx?id=32923
What is an ocular lens on a microscope | www.QACollections.comWhat is an ocular lens on a microscope | www.QACollections.com
The ocular lens is one of two lenses in the optical train of a microscope, the other being the objective lens. Located in the eyepiece, the ocular lens is the nearest lens to the observer's eye providing additional magnification and directing the image into the observer's eye.Total MagnificationThe total magnification of a microscope is the product of the magnification of the ocular lens and the objective lens. For example, a 10x ocular lens and a 40x objective lens produce a total magnification of 400x.Monocular vs. Binocular MicroscopesMonocular microscopes have one ocular lens, while binocular microscopes have two ocular lenses--one for...
http://www.qacollections.com/What-is-an-ocular-lens-on-a-microscope
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Zaidi, Mol Vis 2002; 8:472-476. Figure 2.Zaidi, Mol Vis 2002; 8:472-476. Figure 2.
Figure 2. Medians of normalized data for αA-crystallin from treated (OD) and control (OS) lens samples. A: The OS and OD group medians were 1.01 and 1.05 respectively. Statistical analysis (Wilcoxon Signed Rank Test, p=0.90) revealed no significant difference in αA-crystallin concentration in lenses from form-deprived myopic (OD) and control (OS) eyes. B: The OS and OD group medians were 1.24 and 1.37 respectively. Statistical analysis (Wilcoxon Signed Rank Test, p=0.54) revealed no significant difference in αA-crystallin concentration in lenses from eyes induced with hyperopia (OD) versus control eyes (OS). Statistical analysis (Mann-Whitney, p=0.70) revealed no significance in the difference of medians between the myopic and hyperopic study.. ...
http://www.molvis.org/molvis/v8/a57/zaidi-fig2.html
Cataract | Era Göz Hastanesi
What Is Cataract? Cataract is the loss of transparency of the natural lens in the eye. The lens becomes transparent, frosted or stained glass, and complaints about vision begin. Objects appear as amorphous or fuzzy. Eye fatigue and headache occurs.. The structure of the innate lens in the eye consists of protein and water. The special sequence of the protein ensures that the lens is transparent and transparent. Over the years, small protein molecules begin to clump and eventually lose their lens transparency. When this turbidity covers the entire lens so that it cannot pass the light, mature cataracts occur.. Why Do Cataracts Occur ...
https://en.eragoz.com.tr/katarakt/
gamma C Crystallin Research Products: Novus Biologicalsgamma C Crystallin Research Products: Novus Biologicals
gamma C Crystallin products available through Novus Biologicals. Browse our gamma C Crystallin product catalog backed by our Guarantee+.
https://www.novusbio.com/common-name/gamma-c-crystallin
TOMM34 Polyclonal Antibody - Gardos-Channel-gardos-channel.com
Background: The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein ...
https://www.gardos-channel.com/2017/06/30/TOMM34-Polyclonal-Antibody/
Price Transparency in Healthcare | IBMPrice Transparency in Healthcare | IBM
Learn about the goals of price transparency in healthcare and understand the Hospital Price Transparency and Transparency In Coverage Final Rules
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Pan Beta Crystallins Research Products: Novus BiologicalsPan Beta Crystallins Research Products: Novus Biologicals
Pan Beta Crystallins products available through Novus Biologicals. Browse our Pan Beta Crystallins product catalog backed by our Guarantee+.
https://www.novusbio.com/common-name/pan-beta-crystallins
Creating a Culture of Transparency - SmartData CollectiveCreating a Culture of Transparency - SmartData Collective
So if CEOs are starting to embrace social concepts for their businesses then that means the leadership model is starting to change in these organizations…or at least its starting to get very stressed. At the core of this change though is the concept of transparency. The software that enables social business has inherent transparency built in but is that enough? Unfortunately no, just because you enable information flow doesnt mean that it will actually flow anywhere. Underneath the software theres a need for a culture of transparency, which is fundamentally different from what often happens in businesses today. Transparency is build on trust, or maybe trust is built on transparency…frankly I dont know which comes first, theyre inexorably linked in my mind. I suppose I could have titled this Creating a Culture of Trust just as easily as transparency. Building an organization of trust requires free and open access to information and a culture that encourages openness (which is IMHO a ...
https://www.smartdatacollective.com/21471/
ATGen (182400) Company Profile - CorporateInformation.comATGen (182400) Company Profile - CorporateInformation.com
ATGen operates in the Commercial Physical Research sector. ATGen is a Korea-based company principally engaged in developing and manufacturing reagent used for experimentation . The Companys product portfolio consists of recombination proteins including binding immunoglobulin protein, carboxy terminus of HSP70 interacting protein, BCL2-associated athanogene 2; monoclonal antibodies including 14-3-3 beta antibody, A crystallin A antibody , alpha-crystallin B and NK Vue Kit used for physical examination and diagnosis. The Company distributes its products within domestic market and to overseas markets.
http://www.corporateinformation.com/Company-Snapshot.aspx?cusip=C410CR710
Europe: Unregulated lobbying opens door to… - Transparency.orgEurope: Unregulated lobbying opens door to… - Transparency.org
Transparency International said today that Europe urgently needs lobbying reform. A new report from the anti-corruption group found that of 19 European…
https://www.transparency.org/en/press/europes-unregulated-lobbying-opens-door-to-corruption
ABSORBICA ® -Y MGO DVOJNA VRV L012 14CAABSORBICA ® -Y MGO DVOJNA VRV L012 14CA
Dvojna vrv z integriranim absorberjem energije in MGO priključki ABSORBICA®-Y MGO je dvojni vrv s kompaktnim absorberjem energije, zasnovan za napredovanje na navpični konstrukciji ali…
https://www.stami.si/izdelek/absorbica-y-mgo-dvojna-vrv-l012_14ca/
CRYAACRYAA
Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Crystallins are separated into two classes: ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an ...
https://en.wikipedia.org/wiki/CRYAA
CRYABCRYAB
... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Alpha B chain crystallins (αBC) can be induced by heat shock, ... Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. These ... Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is ... Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein ...
https://en.wikipedia.org/wiki/CRYAB
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... beta-crystallin b chain MeSH D12.776.331.199.750.500 - succinate dehydrogenase MeSH D12.776.377.715.085.050 - alpha 1- ... immunoglobulin heavy chains MeSH D12.776.377.715.548.705.500.350 - immunoglobulin alpha-chains MeSH D12.776.377.715.548.705. ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
CRYBB2CRYBB2
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as ... "Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2 ... Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four ... Beta-crystallin B2 is a protein that in humans is encoded by the CRYBB2 gene. Crystallins are separated into two classes: taxon ...
https://en.wikipedia.org/wiki/CRYBB2
Chromosome 1Chromosome 1
Crystallin zeta CYP4B1 (1p33) CYR61 (1p22) DBT: dihydrolipoamide branched chain transacylase E2 DCLRE1B: DNA cross-link repair ... encoding protein Sterile alpha motif domain containing 11 SDC3: Syndecan-3 SDHB (1p36) SFPQ (1p34) SGIP1: SH3 domain GRB2-like ... 1 alpha subcomplex, 4, 9kda, pseudogene 1 NGF: Nerve Growth Factor NOL9: Nucleolar protein 9 NRAS (1p13) NOTCH2 (1p12) OLFML3: ... encoding TNF alpha induced protein 8 like 2 TNFSF18 (1q25) TNN (1q25) TNNT2: cardiac troponin T2 TOR1AIP1: Torsin-1A- ...
https://en.wikipedia.org/wiki/Chromosome_1
Chromosome 21Chromosome 21
... encoding alpha-2 chain of collagen VI COL18A1: encoding alpha-1 chain of collagen XVIII CRYAA: encoding alpha-crystallin A ... encoding GA-binding protein alpha chain GART: encoding enzyme trifunctional purine biosynthetic protein adenosine-3 GATD3A: ... encoding interferon alpha/beta receptor 1 IFNAR2: encoding interferon alpha/beta receptor 2 IFNGR1: encoding interferon gamma ... chain CRYZL1: Crystallin zeta-like 1 CXADR: encoding protein coxsackievirus and adenovirus receptor CYYR1: Cysteine and ...
https://en.wikipedia.org/wiki/Chromosome_21
Aldo-keto reductaseAldo-keto reductase
... rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide ... Some proteins of this family contain a potassium channel beta chain regulatory domain; these are reported to have ... The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in ...
https://en.wikipedia.org/wiki/Aldo-keto_reductase
Pathophysiology of multiple sclerosisPathophysiology of multiple sclerosis
Bsibsi M, Holtman IR, Gerritsen WH, Eggen BJ, Boddeke E, van der Valk P, van Noort JM, Amor S (2013). "Alpha-B-Crystallin ... free light chains (FLC). Several authors have reported that they are comparable or even better than oligoclonal bands. Multiple ...
https://en.wikipedia.org/wiki/Pathophysiology_of_multiple_sclerosis
PerlecanPerlecan
The N-terminal domain I (aa ~1-195) contains attachment sites for HS chains. Although HS chains are not required for correct ... To this end, a transgenic mouse line was created expressing porcine TGF-β1 under the lens-specific αA-crystallin promoter and ... In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain ... Domain V also has attachment sites for HS/CS chains. Thus, perlecan core protein and HS chains could modulate matrix assembly, ...
https://en.wikipedia.org/wiki/Perlecan
List of A1 genes, proteins or receptorsList of A1 genes, proteins or receptors
... alpha 1 Collagen, type XIX, alpha 1 Collagen, type XXV, alpha 1 Collagen, type XXVII, alpha 1 Crystallin, beta A1 Cyclic ... DP alpha 1 Major histocompatibility complex, class II, DQ alpha 1 Myosin light chain A1, an actin-binding protein NADH ... alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, alpha 1 Collagen, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ...
https://en.wikipedia.org/wiki/List_of_A1_genes,_proteins_or_receptors
Protein footprintingProtein footprinting
Shum WK, Maleknia SD, Downard KM (September 2005). "Onset of oxidative damage in alpha-crystallin by radical probe mass ... The rate or level of oxidation at the reactive amino acid side chains (Met, Cys, Trp, Tyr, Phe, His, Pro and Leu) provides a ... The mechanisms of side chain oxidation were explored by performing the radiolysis reactions in 18O-labeled water. A critical ... Downard KM, Kokabu Y, Ikeguchi M, Akashi S (November 2011). "Homology-modelled structure of the βB2B3-crystallin heterodimer ...
https://en.wikipedia.org/wiki/Protein_footprinting
AgeingAgeing
The cause is lens hardening by decreasing levels of alpha-crystallin, a process which may be sped up by higher temperatures. ... The authors propose that mtDNA mutations lead to respiratory-chain-deficient cells and thence to apoptosis and cell loss. They ... the Growth hormone/Insulin-like growth factor 1 signalling pathway the activity levels of the electron transport chain in ...
https://en.wikipedia.org/wiki/Ageing
Protease inhibitor (biology)Protease inhibitor (biology)
The propeptide region has an open-sandwich antiparallel-alpha/antiparallel-beta fold, with two alpha-helices and four beta- ... is a double-chain inhibitor consisting of an 11-residue and a 41-residue chain. The Carboxypeptidase inhibitor I68 family ... The yeast killer toxin structure was thought to be a precursor of the two-domain beta gamma-crystallin proteins, because of its ... It forms an alpha-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by ...
https://en.wikipedia.org/wiki/Protease_inhibitor_(biology)
Argininosuccinate lyaseArgininosuccinate lyase
Domain 2 contains one small beta sheet, nine alpha helices, and the carboxyl terminus. Three of the nine alpha helices on one ... δ-crystallins are the major structural eye lens water-soluble proteins of most birds, reptiles, and some other vertebrates. ... ASL is composed of four identical monomers; each monomer consisting of a single polypeptide chain between 49 and 52 kDa, ... Two dimers then associate by way of alpha helix, one from each monomer, to form a central 20-helix core. The association of all ...
https://en.wikipedia.org/wiki/Argininosuccinate_lyase
Sean M. DecaturSean M. Decatur
Silva, R.A.G.D., *Nguyen, J.Y., and Decatur, S.M. (2002) "Probing the Effects of Side Chains on the Conformation and Stability ... "Formation of Amyloid Fibrils in Vitro by Human γd-crystallin and its Isolated Domains," Molecular Vision 14:81-89. Decatur, S.M ... "Two dimensional infrared measurements of the coupling of the amide modes of an alpha helix," Chemical Physics Letters 382: 586- ... "Twodimensional IR Spectroscopy and Segmental 13C Labeling reveals the Domain Structure of Human γδ-crystallin amyloid fibrils ...
https://en.wikipedia.org/wiki/Sean_M._Decatur
GlucosepaneGlucosepane
These compounds are thought to act as bidentate nucleophiles that attack the adjacent carbonyls in the alpha-dicarbonyl ... and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane ... This then condenses with the arginine side chain to yield glucosepane in nucleophilic addition-elimination reactions of the ... such as collagen in the skin and crystallin in the eyes. Skin collagen, for instance, has a half-life of fifteen years. Because ...
https://en.wikipedia.org/wiki/Glucosepane
Charles Daniel LaneCharles Daniel Lane
The translation of reticulocyte 9S RNA in frog oocytes gives rise to alpha and beta globin chains. Communication to FEBS ... Berns, A. J. M.; Kraaikamp, M. Van; Bloemendal, H.; Lane, C. D. (1972). "Calf Crystallin Synthesis in Frog Cells: The ...
https://en.wikipedia.org/wiki/Charles_Daniel_Lane
List of MeSH codes (D08)List of MeSH codes (D08)
... cholesterol side-chain cleavage enzyme MeSH D08.244.453.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH D08.244.453.915 ... delta-crystallins MeSH D08.811.520.232.400 - ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811 ... cholesterol side-chain cleavage enzyme MeSH D08.811.682.690.708.170.915.400 - 25-hydroxyvitamin d3 1-alpha-hydroxylase MeSH ... cholesterol 7 alpha-hydroxylase MeSH D08.811.682.690.708.783.212 - cholesterol side-chain cleavage enzyme MeSH D08.811.682.690. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
TransketolaseTransketolase
... and aspartate side-chains, with a glutamate side-chain playing a secondary role. These side-chains, to be specific Arg359, ... and Asp477 forms hydrogen bonds with the alpha hydroxyl group on the substrate, where it works to effectively bind the ... in the mammalian cornea by the stromal keratocytes and epithelial cells and is reputed to be one of the corneal crystallins. ... To be specific, the His 263 and His30 side-chains form hydrogen bonds to the aldehyde end of the substrate, which is deepest ...
https://en.wikipedia.org/wiki/Transketolase
List of distinct cell types in the adult human bodyList of distinct cell types in the adult human body
... alpha and gamma-endorphin, bombesin Thyroid gland cells Thyroid epithelial cell Parafollicular cell Parathyroid gland cells ... Intermediate skeletal muscle cell Nuclear bag cell of muscle spindle Nuclear chain cell of muscle spindle Myosatellite cell ( ... Medium spiny neurons Astrocytes Oligodendrocytes Ependymal cells Tanycytes Pituicytes Anterior lens epithelial cell Crystallin- ... Parathyroid chief cell Oxyphil cell Pancreatic islets (islets of Langerhans) Alpha cell (secretes glucagon) Beta cell (secretes ...
https://en.wikipedia.org/wiki/List_of_distinct_cell_types_in_the_adult_human_body
ProteinopathyProteinopathy
Ecroyd H, Carver JA (January 2009). "Crystallin proteins and amyloid fibrils". Cellular and Molecular Life Sciences. 66 (1): 62 ... Badar T, D'Souza A, Hari P (2018). "Recent advances in understanding and treating immunoglobulin light chain amyloidosis". ... "Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein". Proceedings of the ... In immunoglobulin light chain amyloidosis (AL amyloidosis), chemotherapy can be used to lower the number of the blood cells ...
https://en.wikipedia.org/wiki/Proteinopathy
Amyloid betaAmyloid beta
"Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the ... Oligomerization is a chemical process that converts individual molecules into a chain consisting of a finite number of ... Intra-cellular deposits of tau protein are also seen in the disease, and may also be implicated, as has aggregation of alpha ... leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in ...
https://en.wikipedia.org/wiki/Amyloid_beta
alpha-Crystallin B Chain/genetics/*physiology | Glembotski..."alpha-Crystallin B Chain/genetics/*physiology" | Glembotski...
"alpha-Crystallin B Chain/genetics/*physiology". Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ...
https://www.glembotskilab.org/tag/alpha-crystallin-b-chain/genetics/physiology/
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBioAnti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio
HSPB8 , Alpha-crystallin C chain , CMT2L , Crystallin alpha c , DHMN2 , E2-induced gene 1 protein , CRYAC , E2IG1 , HMN2 , H11 ...
https://www.lsbio.com/antibodies/hspb8-antibody-h11-antibody-hsp22-antibody-clone-oti1e3-flow-if-immunofluorescence-wb-western-ls-c337133/347744
Light scattering of human lens vesicles in vitroLight scattering of human lens vesicles in vitro
... was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. Increased ... The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. Hydrocarbon chain ... lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid ...
https://pubmed.ncbi.nlm.nih.gov/12697424/
GlyConnectGlyConnect
32 Alpha crystallin - a and b chains Bos taurus P02510 # id : 32 Alpha crystallin - a and b chains Bos taurus ... 33 Alpha crystallin - a and b chains Homo sapiens P02489 # id : 33 Alpha crystallin - a and b chains Homo sapiens ... 34 Alpha crystallin - a and b chains Rattus norvegicus P24623 # id : 34 Alpha crystallin - a and b chains Rattus norvegicus ... Alpha crystallin - a and b chains / Bos taurus P02470 P02510 # Export GlyConnect protein list related to protein with id 32 ...
https://glyconnect.expasy.org/o-monosaccharide/proteins?n=0
GlyConnectGlyConnect
Alpha crystallin b chain (b2 subunit) (Bos taurus). All glycosylation sites SNFG, Text, Oxford ... Alpha crystallin b chain (b2 subunit) / Bos taurus P02510 # Export GlyConnect protein list related to glycosylation_site_ ... structure with id 3800000008849 P02510 # id : 38 Alpha crystallin b chain (b2 subunit) Bos taurus ... Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (1991 - Roquemore E, Dell A, Hart G) / Status : ...
https://glyconnect.expasy.org/o-monosaccharide/proteins/38/sites
GeniePlex Rat LIX/GCP2/CXCL5 Multiplex AssayGeniePlex Rat LIX/GCP2/CXCL5 Multiplex Assay
Rat Alpha-crystallin A chain (Cryaa) ELISA KitProduct Code:RTEB0981Alias:Alpha-crystallin A chain, Cryaa,... ...
https://www.assaygenie.com/genieplex-rat-lix-gcp2-cxcl5-immunoassay/
Infantile muscular dystrophy in Canadian aboriginals is an αb-crystallinopathy<...
Crystallins Medicine & Life Sciences 72% * alpha-Crystallin B Chain Medicine & Life Sciences 48% ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ... Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. ...
https://mayoclinic.pure.elsevier.com/en/publications/infantile-muscular-dystrophy-in-canadian-aboriginals-is-an-%CE%B1b-cry
DeCSDeCS
alpha-Crystallin B Chain Entry term(s). B Chain, alpha-Crystallin B Subunit alpha-Crystallin Crystallins, alpha B Chain ... alpha B Crystallin alpha B-Crystallin alpha Crystallin B Chain alpha Crystallin, B Subunit alpha-Crystallin, B Subunit ... alpha B Crystallin. alpha B-Crystallin. alpha Crystallin B Chain. alpha Crystallin, B Subunit. alpha-Crystallin, B Subunit. ... Chaîne B de la cristalline alpha Entry term(s):. B Chain, alpha-Crystallin. B Subunit alpha-Crystallin. Crystallins, alpha B ...
https://decs.bvsalud.org/en/ths/resource/?id=37441
IMSEAR at SEARO: Search
1 alpha-Crystallin A Chain --isolat.... *. next > Date issued. *1 2010 - 2011 ... Lens proteome map and -crystallin profile of the catfish Rita rita.. Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas ...
https://imsear.searo.who.int/handle/123456789/1364/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=subject&filter_type_1=equals&filter_value_1=Mice&etal=0&filtername=subject&filterquery=Cattle&filtertype=equals
CRYAB Antibody Monoclonal | HSPB5 Antibody | ProSpecCRYAB Antibody Monoclonal | HSPB5 Antibody | ProSpec
Alpha crystallins are composed of two gene products; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins ... Mouse IgG2b heavy chains and κ light chain.. Purification Method. CRYAB antibody was purified from mouse ascitic fluids by ... the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of -crystallins are an autokinase ... Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. ...
https://www.prospecbio.com/cryab_antibody
Pesquisa | Prevenção e Controle de CâncerPesquisa | Prevenção e Controle de Câncer
... alpha 1; CRYBA1: crystallin, beta A1; DAPI: 46-diamino-2-phenylindole; EGFR: epidermal growth factor receptor; GAPDH: ... ferritin heavy chain 1; GPX: glutathione peroxidase; GST: glutathione S-transferase; H2O2: hydrogen peroxide; His280: histidine ... Herein, we demonstrate an important role for ßA3/A1-crystallin in RPE. ßA3/A1-crystallin deficiency leads to clathrin-mediated ... We found that ßA3/A1-crystallin binds to phosphatidylinositol transfer protein (PITPß) and that ßA3/A1-crystallin deficiency ...
https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=au:Grebe,+Rhonda
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
collagen type IV alpha 6 chain. protein-coding. CXXC5. CXXC finger protein 5. protein-coding. ... crystallin alpha B. protein-coding. CDC42EP4. CDC42 effector protein 4. protein-coding. ... C3 and PZP like, alpha-2-macroglobulin domain containing 8. protein-coding. ...
https://www.genscript.com/gene/9823/sus-scrofa?search=c
PDGF-ABELISA檢測試劑盒價格48T/96T-上海一研生物
晶狀體蛋白αA檢測試劑盒Alpha-crystallin A chain 定做種屬檢測試劑盒/中藥材鑒定試劑盒
http://www.sb1516.com/Products-33078575.html
KIT - IBG2Teaching and Seminars - Group Seminar - Past group seminarsKIT - IBG2Teaching and Seminars - Group Seminar - Past group seminars
Polydisperse alpha B-crystallin - About termini and finding the right groove". 20.05 Thilo Mast (Vertiefer student). "Synthese ... Synthesis of photoswitchable side-chain stapled helical peptides. 22.05. Volodymyr Kubyshkin (TU Berlin). What can proline ... "Analysis of the orientation of fluor-labeled amino acid side chains at various positions. inside peptides via molecular ... "Rekombinante Expression des Transmembransegments de T-Zell Receptors alpha". Papia Sanyal. "Promotion, inhibition and killing ...
https://www.ibg.kit.edu/nmr/902.php
ORF Clones: Search resultORF Clones: Search result
Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA.. A8610. ... Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 2, mRNA.. A7467. ... Homo sapiens crystallin alpha A (CRYAA), mRNA.. D0373. NM_013501.3. Cryaa. Acry-1, Crya-1, Crya1, DAcry-1, lop18. Mouse. Mus ... Mus musculus crystallin, alpha A (Cryaa), transcript variant 1, mRNA.. Mm36859. NM_001278570.1. Cryaa. Acry-1, Crya-1, Crya1, ...
https://www.genecopoeia.com/product/search/result.php?key=CRYAA&prt=25&field=0
DeCS 2016 - June 12, 2016 versionDeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs.bvs.br/I/DeCS2016_Alfab-B.htm
cataract | Leaders in Pharmaceutical Business Intelligence (LPBI) Groupcataract | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the ... The amino acid sequences of the a-crystallin A and B chains of the dogfish, Squalus acanthias, have been determined. Comparison ... some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene ... Speculation emerged that these structures were thin filaments with bound alpha crystallin particles, or nucleosomes on DNA, but ...
https://pharmaceuticalintelligence.com/tag/cataract/
aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológicaaa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica
Recombination and identification of human alpha B-crystallin.. *. Preston. To recombine the human alpha B-crystallin (αB- ... A Guide to Cloning the Products of Polymerase Chain Reactions. *. Preston. This introduction outlines varied strategies to ... human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, ... Due to the benefit with which the termini of amplified DNAs will be tailor-made by polymerase chain response (PCR), most of the ...
https://www.aprofarm.org/category/aa-214/page/3/
Keith Van Haren, MDs Profile | Stanford ProfilesKeith Van Haren, MD's Profile | Stanford Profiles
... and alpha-B-crystallin. In contrast, MS was characterized by IgM autoantibodies targeting myelin basic protein, proteolipid ... We performed a combination of tests: (i) a test for very-long-chain fatty acids (VLCFA) levels, (ii) a D3-C22:0 loading test to ... The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin ... saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have ...
https://profiles.stanford.edu/keith-vanharen?tab=bio
SCOP 1.71: Domain d1u15a : 1u15 ASCOP 1.71: Domain d1u15a : 1u15 A
d1u15a_ a.127.1.1 (A:) Argininosuccinate lyase/delta-crystallin {Domestic duck (Anas platyrhynchos), delta-crystallin} ... Class a: All alpha proteins [46456] (226 folds). *. Fold a.127: L-aspartase-like [48556] (1 superfamily). multihelical, ... Domains from other chains:. (mouse over for more information). d1u15b_, d1u15c_, d1u15d_ ... Protein Argininosuccinate lyase/delta-crystallin [48564] (4 species). *. Species Domestic duck (Anas platyrhynchos), delta- ...
http://scop.berkeley.edu/sunid=112948&ver=1.71
尋找研究成果 - 臺北醫學大學
Cloning of a putative chicken MHC class II alpha chain gene.. Kivela, J., Kung, H. J., Dodgson, J. & Bacon, L., 1月 1 1987, 於: ... Cloning and sequencing of a carp βs-crystallin cDNA. Chang, T. & Chang, W. C., 10月 9 1987, 於: BBA - Gene Structure and ... Extracellular thermostable alpha-amylase from Bacillus stearothermophilus Q8. Lin, H. Y. & Tsay, S. S., 1月 1 1987, 於: Zhonghua ...
https://tmu.pure.elsevier.com/zh/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Findustry_innovation_and_infrastructure&format=&ordering=publicationYearThenTitle&descending=true&page=886
Domain IPR003439:ABC transporter-likeDomain IPR003439:ABC transporter-like
Alpha-D-phosphohexomutase, alpha/beta/alpha domain II 76 Domain IPR002068:Alpha crystallin/Hsp20 domain 75 Domain IPR001030: ... alpha chain 2 Domain IPR025959:Winged helix-turn helix domain 2 Family IPR022053:Protein of unknown function DUF3613 2 Domain ... alpha/beta subunit, N-terminal domain 81 Domain IPR001623:DnaJ domain 81 Domain IPR005846:Alpha-D-phosphohexomutase, alpha/beta ... Alpha-D-phosphohexomutase, alpha/beta/alpha domain I 74 Domain IPR008333:Oxidoreductase, FAD-binding domain 74 Domain IPR000064 ...
https://www.cbrc.kaust.edu.sa/aamg/1502720332816_CamiLowProdigalV2_40.0_intikhab/WWWAAMG/visuals/CamiLowProdigalV2_AAMG_DOMAINS_data_summary.txt
GSE360 DC VS MAC L MAJOR UPGSE360 DC VS MAC L MAJOR UP
crystallin alpha A [Source:HGNC Sym.... CSF1R. 1436. CSF1R. colony stimulating factor 1 recepto.... ... dynein axonemal heavy chain 17 [Sou.... DNPEP. 23549. DNPEP. aspartyl aminopeptidase [Source:HGN.... ...
https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE360_DC_VS_MAC_L_MAJOR_UP.html
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
https://www.medscape.com/answers/1953022-186640/what-is-the-role-of-urinary-biomarkers-in-bladder-cancer-surveillance
Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...Urine Tumor Markers in Bladder Cancer Diagnosis: Overview of Urine Tumor Markers, Genetic Aberrations in Bladder Cancer,...
Mark H Katz, MD is a member of the following medical societies: Alpha Omega Alpha, American Urological Association, ... Reverse transcription quantitative polymerase chain reaction (RT-PCR) for messenger RNA (CxBladder, Xpert) ... CRYAB (alpha B-crystallin) * CGNL1 (cingulin-like 1) * GPX3 (glutathione peroxidase 3) ... use reverse transcription polymerase chain reaction (RT-PCR) to detect messenger RNA (mRNA) in urine samples. ...
http://emedicine.medscape.com/article/1953022-overview
DeCS 2018 - July 31, 2018 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2018.bvsalud.org/I/DeCS2018_Alfab-B.htm
DeCS 2017 - July 04, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2017.bvsalud.org/I/DeCS2017_Alfab-B.htm
DeCS 2016 - June 12, 2016 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2019.bvsalud.org/I/DeCS2016_Alfab-B.htm
DeCS 2017 - December 21, 2017 version
B Chain, alpha-Crystallin use alpha-Crystallin B Chain B Chain, beta-Crystallin use beta-Crystallin B Chain ... B Cell Heavy Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Heavy Chain ... B Cell kappa Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ... B Cell kappa-Chain Gene Rearrangement use Gene Rearrangement, B-Lymphocyte, Light Chain ...
https://decs2020.bvsalud.org/I/DeCS2017_Alfab-B.htm
IMP: Integrative Multi-species Prediction
crystallin, alpha A. 0.016. Olfr159. olfactory receptor 159. 0.016. Myh8. myosin, heavy polypeptide 8, skeletal muscle, ... hemoglobin Y, beta-like embryonic chain. 0.014. Rbp3. retinol binding protein 3, interstitial. 0.014. ... mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative). 0.010. ... serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10. 0.014. ...
http://imp.princeton.edu/predictions/process/mouse-context-global/8070/?gene=88781
SubunitProteinsCRYABSubunitsCRYAAGeneLensProteinAntibodyMRNAChromosomeDyneinHumanTroponinAttached to the coTissuesMouseLightLensELISA KitGlycoproteinMammalianNeurological diseasesAntibodyGammaSubunit alphaRecombinantPutativeSequenceAntigensGene ExpressionZetaCollagen typeAntibodiesDomainMutantSymbol20kDaBreastStructuralBetaMeshPeptideNuclearDescriptionMajorSpecificAcidActivityStructure
Subunit1
  • SLBB domain, 4Fe-4S dicluster domain, RnfC Barrel sandwich hybrid domain, Respiratory-chain NADH dehydrogenase 51 Kd subunit [Interproscan]. (ntu.edu.sg)
Proteins4
  • However, fast skeletal myosin light chain 2 followed by troponin T, F-actin-capping and small heat shock proteins showed the greatest phosphorylation change, and therefore they were the most important phosphoproteins underlying LT muscle conversion to DFD meat in the Rubia Gallega breed. (biomedcentral.com)
  • A total of 21 proteins were successfully identified by MALDI-TOF-MS analysis, among which some interesting proteins, such as alpha B-crystallin, annexin A2, and stathmin 1, had been reported to involve in cell proliferation and differentiation through different signaling pathways. (big.ac.cn)
  • Utilizing a betasheet of the human ubiquitin for paratope creation we obtained binding proteins against tumor necrosis factor (TNF)-alpha. (navigo-proteins.com)
  • The molecular chaperone αB-crystallin, the major player in maintaining the transparency of the eye lens, prevents stress-damaged and aging lens proteins from aggregation. (cipsm.de)
CRYAB1
  • To recombine the human alpha B-crystallin (αB-crystallin) utilizing gene cloning expertise and prokaryotic expression vector and ensure the organic exercise of recombinant human αB-crystallin.Cloning the human αB-crystallin cDNA in line with the nucleotide sequence of the human αB-crystallin, setting up the pET-28/CRYAB prokaryotic expression plasmid by restriction enzyme digestion technique, and stably expressing remodeled into the Escherichia coli (E. coli) DH5 alpha. (aprofarm.org)
Subunits3
  • Bovine lens alpha-crystalline subunits are modified by O-linked GlcNAc. (expasy.org)
  • One of the alpha crystallin subunits. (bvsalud.org)
  • the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. (prospecbio.com)
CRYAA1
Gene2
  • 8] Moreover, an analysis of antigen receptor H chain gene transcripts of B and plasma cells isolated from s-IBM muscle showed evidence of clonal expansion and variation, isotype switching, and somatic hypermutation, indicative of a local antigen-driven humoral response. (medscape.com)
  • A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. (musclegenetable.fr)
Lens1
  • The intensity of light scattered by human lens LUVs increased with age and lipid hydrocarbon chain order. (nih.gov)
Protein2
  • Alpha B-crystallin (αBC) expression was absent from all fibers using a monoclonal antibody raised against the entire protein. (elsevier.com)
  • Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). (prospecbio.com)
Antibody1
  • Various concepts for new formats combining antibody chains or antibody fragments and fusions with other entities have been developed recently. (navigo-proteins.com)
MRNA1
  • Homo sapiens alpha-crystallin A chain (LOC102724652), transcript variant 1, mRNA. (genecopoeia.com)
Chromosome1
  • A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12. (musclegenetable.fr)
Dynein1
Human2
  • Recombination and identification of human alpha B-crystallin. (aprofarm.org)
  • Accumulation of amyloid in breast cancer is a well-known phenomenon, but only immunoglobulin light-chain amyloidosis (AL) or transthyretin (TTR) amyloid had been detected in human breast tumor samples previously. (inyushinlab.org)
Troponin1
  • Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere. (musclegenetable.fr)
Attached to the co1
  • These dyes differ in the number of polyethylene glycol (PEG) chains attached to the core structure which is either a perylene derivate or a terrylene derivate. (cipsm.de)
Tissues2
  • Alpha-B is expressed widely in many tissues and organs and occurs in many neurological diseases. (prospecbio.com)
  • The biochemical hallmark of the disease is an accumulation of very-long chain fatty acids in several tissues, including myelin and blood. (stanford.edu)
Mouse2
  • Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model. (glembotskilab.org)
  • Mouse IgG2b heavy chains and κ light chain. (prospecbio.com)
Light3
  • Hydrocarbon chain order also correlated with light scattering intensity by sphingomyelin LUVs. (nih.gov)
  • Light scattered by LUVs composed of sphingomyelin (1-30 mg ml(-1)) was 20 to 100 times more intense than that scattered by the same concentration of alpha-crystallin in aqueous media. (nih.gov)
  • Increased lipid hydrocarbon chain order as well as variations in the headgroup and interfacial region of bilayers resulting from lipid compositional changes can influence membrane light scattering properties. (nih.gov)
Lens8
  • Genes associated with the development of lens include crystallin genes. (nih.gov)
  • From NCBI Gene: Mammalian lens crystallins are divided into alpha, beta, and gamma families. (nih.gov)
  • alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. (nih.gov)
  • The extent of normal lens lipid hydrocarbon chain order increased with age from the equatorial and cortical regions to the nucleus. (arvojournals.org)
  • Increased lipid oxidation and hydrocarbon chain disorder correlate with increased lens nuclear opacity in the in vivo HBO model. (arvojournals.org)
  • Since it has been shown that lens injury may promote nerve regeneration, crystallin has been an area of neural research. (absoluteastronomy.com)
  • It is becoming increasingly clear that crystallins may have several metabolic and regulatory functions, both within the lens and in other parts of the body. (absoluteastronomy.com)
  • Yamada T、Tsuchida S. The Hirosaki small-eye rat: A novel recessive model animal of lens and retinal degeneration with loss of A3/A1-crystallin. (nichiyaku.ac.jp)
ELISA Kit2
  • Description: A sandwich ELISA kit for detection of Fibrinogen Alpha from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
  • Should the Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (wildpalm.net)
Glycoprotein1
  • We have examined the cleavage of ribonuclease A and the related N-linked glycoprotein ribonuclease B, and the O-linked glycoprotein alpha crystallin A chain, using MALDI-TOF and LC-ESI-MS to identify the peptide products. (researchgate.net)
Mammalian1
  • In addition, fish γM-crystallins do not conserve the paired tryptophan residues found in each domain in mammalian γ-crystallins and in the related β-crystallins. (nih.gov)
Neurological diseases1
  • Crystallins are divided into B-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy. (neobiotechnologies.com)
Antibody5
  • Formalin-fixed, paraffin-embedded human Breast stained with Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • Western Blot Analysis of HeLa cell lysate using Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • SDS-PAGE Analysis Purified Crystallin Alpha B Mouse Monoclonal Antibody (CPTC-CYRAB-1). (neobiotechnologies.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Fibrinogen Alpha (FGa) in Plasma. (scalegen.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Fibrinogen Alpha (FGa) in samples from Plasma with no significant corss-reactivity with analogues from other species. (scalegen.com)
Gamma3
  • Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses. (uams.edu)
  • crystallin beta-gamma domain containi. (gsea-msigdb.org)
  • Alpha, beta, and gamma tubulins have all been used as loading controls. (neobiolab.com)
Subunit alpha1
  • Description: A competitive ELISA for quantitative measurement of Human Voltage dependent N type calcium channel subunit Alpha 1B(CACNA1B) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (wildpalm.net)
Recombinant10
  • IFI30 Human Recombinant produced in E. coli is a single polypeptide chain containing 199 amino acids (58-232) and having a molecular mass of 22.5 kDa. (neobiolab.com)
  • IFNA1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 167 amino acids (24-189) and having a molecular mass of 19.5 kDa. (neobiolab.com)
  • Interferon-alpha 1a Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19.4 kDa.The Interferon-alpha 1a contains Valine residue at position 114.The IFN-a 1a is purified by proprietary chromatographic techniques. (neobiolab.com)
  • Interferon-a 2b Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19269 Dalton. (neobiolab.com)
  • Interferon-beta 1a Human Recombinant produced in CHO (Chinese Hamster Ovarian) cells is a single, glycosylated polypeptide chain containing 166 amino acids and having a molecular mass of 22500 Dalton.IFN-beta1a is purified by proprietary chromatographic techniques. (neobiolab.com)
  • Interferon beta 1b Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human Interferon beta-1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510.86 Dalton.The IFN-beta gene was cloned from human fibroblasts and altered to substitute Serine for the Cysteine residue found at position 17. (neobiolab.com)
  • Description: TDG Human Recombinant produced in E. coli is a single polypeptide chain containing 433 amino acids (1-410) and having a molecular mass of 48.4 kDa. (gentaur.se)
  • BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.BMP-5 is purified by proprietary chromatographic techniques. (kendallscientific.com)
  • BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, Polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. (kendallscientific.com)
  • BMPR1A Human Recombinant produced in HEK-293 cells is a single, glycosylated, polypeptide chain containing 369 amino acids with a molecular weight of43.7 kDa thoµgh on SDS-PAGE migrates at about 50 kDa due to the glycosilation.The BMPR1A is purified by proprietary chromatographic techniques. (kendallscientific.com)
Putative1
  • Cloning of a putative chicken MHC class II alpha chain gene. (elsevier.com)
Sequence1
  • The DNA sequence encoding the human BMP-2 signal peptide and propeptide (1~282 amino acid) fused to the human rhBMP-7 mature chain (293~431 amino acid) was expressed in a Chinese hamster ovary cell line. (kendallscientific.com)
Antigens2
  • Specifically, this diagnostic approach exploits M. tuberculosis secreted latency specific antigens, such as alpha-crystallin, in the blood or urine of patients. (nih.gov)
  • These antigens have a heavy chain and an associated light chain. (medscape.com)
Gene Expression1
  • Gene expression changes induced by short-term tumor necrosis factor-alpha (TNF-α) treatment were largely sustained in the FLS exposed to chronic inflammation. (surfaceyourrealself.com)
Zeta1
Collagen type3
Antibodies1
  • we performed immunohistochemistry on sectioned Myf-5 and MyoD mutant embryos with antibodies reactive with desmin , nestin, myosin heavy chain, sarcomeric actin, Myf-5, MyoD and myogenin. (labome.org)
Domain1
  • C.A. Barnes, Y. Shen, J. Ying, and A. Bax: Modulating the Stiffness of the Myosin VI Single alpha-Helical Domain. (nih.gov)
Mutant1
  • Mutant (P182L) but not wild-type HSPB1 led to the formation of insoluble intracellular aggregates and to the sequestration in the cytoplasm of selective cellular components, including neurofilament middle chain subunit (NF-M) and p150 dynactin. (lookformedical.com)
Symbol1
20kDa1
  • The Pegylated IFN-a 2b is produced by attaching a 20kDa mPEG-aldehyde to the N-terminal IFN alpha-2b. (neobiolab.com)
Breast2
  • 10. Alpha-crystallin B chains in trastuzumab-resistant breast cancer cells promote endothelial cell tube formation through activating mTOR. (nih.gov)
  • 18. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. (nih.gov)
Structural2
  • An alpha and beta tubulin heterodimer is the basic structural unit of microtubules. (neobiolab.com)
  • S.C. Chiliveri, J.M. Louis, and A. Bax: Concentration-dependent structural transition of the HIV-1 gp41 MPER peptide into alpha-helical trimers. (nih.gov)
Beta2
  • The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. (neobiolab.com)
  • TCR beta-chain does not appear to interact directly with beta2M. (cusabio.com)
Mesh1
  • Crystallins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
Peptide1
  • A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of. (absoluteastronomy.com)
Nuclear1
Description3
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Fibrinogen Alpha (FGa) in samples from plasma. (scalegen.com)
  • Description: A competitive ELISA for quantitative measurement of Mouse fibrinogen alpha chain(FGA) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B) in samples from tissue homogenates, cell lysates or other biological fluids. (wildpalm.net)
Major1
  • This graph shows the total number of publications written about "Crystallins" by people in UAMS Profiles by year, and whether "Crystallins" was a major or minor topic of these publications. (uams.edu)
Specific1
  • A specific phosphorylation regulates the protective role of αA-crystallin in diabetes. (vanderbilt.edu)
Acid2
  • The linkage of the glycosidic group to the asparagine side-chain in ribonuclease B was found not to be cleaved by brief microwave treatment in 12.5 % acetic acid. (researchgate.net)
  • The distribution of the heterogeneous carbohydrate side chain in the glycopeptide products of acid cleavage was compared to that of the glycopeptide products of tryptic digestion. (researchgate.net)
Activity1
  • Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. (nih.gov)
Structure1
  • Solution Structure of the alpha-crystallin do. (nih.gov)
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio
Anti-HSPB8 / H11 / HSP22 Antibody | Mouse anti-Human Monoclonal | LSBio (lsbio.com)
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1
Browse ORF cDNA clones by species Sus scrofa, letter c, page 1 (genscript.com)
Lens proteins | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Lens proteins | Leaders in Pharmaceutical Business Intelligence (LPBI) Group (pharmaceuticalintelligence.com)
Shop - dianova
Shop - dianova (dianova.com)
Aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica
Aa 214 - Page 3 - Aprofarm Formulación Magistral Farmacológica (aprofarm.org)
Keith Van Haren, MD's Profile | Stanford Profiles
Keith Van Haren, MD's Profile | Stanford Profiles (profiles.stanford.edu)
SCOP 1.71: Domain d1u15a_: 1u15 A
SCOP 1.71: Domain d1u15a_: 1u15 A (scop.berkeley.edu)
SCOPe 2.08: Structural Classification of Proteins - extended
SCOPe 2.08: Structural Classification of Proteins - extended (scop.berkeley.edu)
SCOPe 2.07: Domain d1u16a_: 1u16 A
SCOPe 2.07: Domain d1u16a_: 1u16 A (scop.berkeley.edu)
The first evidence of global meat phosphoproteome changes in response to pre-slaughter stress | BMC Genomics | Full Text
The first evidence of global meat phosphoproteome changes in response to pre-slaughter stress | BMC Genomics | Full Text (bmcgenomics.biomedcentral.com)
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? ? / ??????? 2019 ??? (idbras.ru)
Eisenberg, David S.<...
Eisenberg, David S.<... (chemistry.ucla.edu)
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) | BMC Biology |...
Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio) | BMC Biology |... (bmcbiol.biomedcentral.com)
Congenital Myopathies Clinical Presentation: History, Nemaline Rod Myopathy, Core Myopathy
Congenital Myopathies Clinical Presentation: History, Nemaline Rod Myopathy, Core Myopathy (medscape.com)
Congenital Myopathies Clinical Presentation: History, Nemaline Rod Myopathy, Core Myopathy
Congenital Myopathies Clinical Presentation: History, Nemaline Rod Myopathy, Core Myopathy (medscape.com)
Congenital Myopathies Treatment & Management: Approach Considerations, Medical Care, Surgical Care
Congenital Myopathies Treatment & Management: Approach Considerations, Medical Care, Surgical Care (medscape.com)
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations | Science...
A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations | Science... (science.org)
Congenital Myopathies: Background, Pathophysiology, Epidemiology
Congenital Myopathies: Background, Pathophysiology, Epidemiology (emedicine.medscape.com)
Inyushin Lab - UCC, School of Medicine
Inyushin Lab - UCC, School of Medicine (inyushinlab.org)
MeSH Browser
MeSH Browser (meshb.nlm.nih.gov)