Chlorohydrins: Any of the compounds derived from a group of glycols or polyhydroxy alcohols by chlorine substitution for part of the hydroxyl groups. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Ethylene Chlorohydrin: Used as a solvent, in the manufacture of insecticides, and for treating sweet potatoes before planting. May cause nausea, vomiting, pains in head and chest, stupefaction. Irritates mucous membranes and causes kidney and liver degeneration.Ethylene Dichlorides: Toxic, chlorinated, saturated hydrocarbons. Include both the 1,1- and 1,2-dichloro isomers. The latter is considerably more toxic. It has a sweet taste, ethereal odor and has been used as a fumigant and intoxicant among sniffers. Has many household and industrial uses.Hypochlorous Acid: An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.National Institute for Occupational Safety and Health (U.S.): An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.Respiratory Protective Devices: Respirators to protect individuals from breathing air contaminated with harmful dusts, fogs, fumes, mists, gases, smokes, sprays, or vapors.Air Pollutants, Occupational: Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.Therapeutics: Procedures concerned with the remedial treatment or prevention of diseases.Accidents, Occupational: Unforeseen occurrences, especially injuries in the course of work-related activities.United StatesOccupational Health: The promotion and maintenance of physical and mental health in the work environment.Epichlorohydrin: A chlorinated epoxy compound used as an industrial solvent. It is a strong skin irritant and carcinogen.alpha-Chlorohydrin: A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.Rats, Inbred F344Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Acetylcysteine: The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.Urine: Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Epoxide Hydrolases: Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.Aspergillus niger: An imperfect fungus causing smut or black mold of several fruits, vegetables, etc.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.O(6)-Methylguanine-DNA Methyltransferase: An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA, to a cysteine residue in itself, thus repairing alkylated DNA in a single-step reaction. EC 2.1.1.63.Nitrosourea CompoundsOctanes: Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.KetonesCyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.Pyridones: Pyridine derivatives with one or more keto groups on the ring.Amanita: A genus of fungi of the family Agaricaceae, order Agaricales; most species are poisonous.Mushroom Poisoning: Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.Fatty Acids, Monounsaturated: Fatty acids which are unsaturated in only one position.Fruiting Bodies, Fungal: The fruiting 'heads' or 'caps' of FUNGI, which as a food item are familiarly known as MUSHROOMS, that contain the FUNGAL SPORES.2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.Amanitins: Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.CyclopropanesVolatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cycloparaffins: Alicyclic hydrocarbons in which three or more of the carbon atoms in each molecule are united in a ring structure and each of the ring carbon atoms is joined to two hydrogen atoms or alkyl groups. The simplest members are cyclopropane (C3H6), cyclobutane (C4H8), cyclohexane (C6H12), and derivatives of these such as methylcyclohexane (C6H11CH3). (From Sax, et al., Hawley's Condensed Chemical Dictionary, 11th ed)Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Air Pollutants: Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Great BritainNetherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Coordination Complexes: Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.Glycerophospholipids: Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.Glycerol: A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.Sphingolipids: A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Phosphatidylethanolamines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.Skin Cream: A water-soluble medicinal preparation applied to the skin.

alpha-Chlorohydrin inhibits glyceraldehyde-3-phosphate dehydrogenase in multiple organs as well as in sperm. (1/35)

Numerous studies have documented inhibitory effects of alpha-chlorohydrin (ACH) on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) activity in spermatozoa. A sperm-specific G3PDH isoform has been described. The possibility that ACH may inhibit G3PDH in cell types other than sperm was investigated in this work. In addition, the onset of ACH-induced epididymal toxicity was described. Changes to epididymal histology occurred 6 h following a single dose of ACH (50 mg/kg po) and were confined to the proximal initial segment. By 24 h, no epithelial cells lined the basement membrane of that region. Three h after ACH administration (50 mg/kg po), G3PDH activity was significantly decreased in sperm (85%) as well as in kidney (31%), liver (49%), and epididymis (35%). Enzyme activity remained inhibited at 6 and 24 h. G3PDH was immunolocalized in the epididymis and staining was highest in the efferent ducts and initial segment as well as in smooth muscle. Since G3PDH is a microtubule-associated protein and microtubule-dependent endocytosis occurs in the epididymis, beta-tubulin was also immunolocalized. beta-tubulin densely stained the apical region of initial segment and caput epithelial cells. Disruption of beta-tubulin immunostaining correlated with the localization and onset of the lesion. Co-localization of G3PDH and beta-tubulin immunostaining was not observed although both antibodies most densely stained the initial segment. Our data indicate that histologic changes to the proximal initial segment of the epididymis occur rapidly, but subsequent to G3PDH inhibition. Moreover, ACH inhibition of G3PDH is not confined to sperm, although the sperm enzyme is most sensitive to inhibition.  (+info)

Phagocytosis of spermatozoa by the epithelial cells of the ductuli efferentes after epididymal obstruction in the rat. (2/35)

The effects of ligation of an isolated loop of the ductus epididymidis in the region of the caput were compared with those of the exfoliative lesion of the epididymis that follows administration of alpha-chlorhydrin to rats. Electron micrographs of the ductuli efferentes in both cases revealed early phagocytosis of apparently normal spermatozoa by the epithelial cells, followed at later intervals by invasion of macrophages and intraluminal phagocytosis. It is concluded that epithelial spermiophagy is a consequence of obstruction, whether mechanically or chemically induced.  (+info)

Purification and properties of arylsulphatase A from rabbit testis. (3/35)

Rabbit testis arylsulphatase A was purified 140-fold with a recovery of 20% from detergent extracts of an acetone-dried powder by using DE-52 cellulose column chromatography, gel filtration on Sephadex G-200 and preparative isoelectric focusing. The purified enzyme showed one major band with one minor contaminant on electrophoresis in a 7.5% (w/v) polyacrylamide gel at pH8.3. On sodiumdodecyl sulphate/polyacrylamidegel electrophoresis, a single major band was observed with minor contaminants. The final preparation of enzyme was free from general proteolytic, esterase, hyaluronidase, beta-glucuronidase and beta-galactosidase activities. Rabbit testicular arylsulphatase A exists as a dimer of mol.wt. 110000 at pH7.1. At pH5.0 the enzyme is a tetramer of mol.wt. 220000. Arylsulphatase A appears to consist of two identical subunits of mol.wt. 55000 each. The highly purified enzyme has pI4.6. The enzyme hydrolyses p-nitrocatechol sulphate with Km and Vmax, of 4.1 mM and 80nmol/min respectively, but has no activity toward p-nitrophenyl sulphate. The pH optimum of the enzyme varies with the incubation time. By applying Sephacex G-200 chromatography and preparative isoelectric focusing, one form of enzyme was obtained. The enzyme has properites common to arylsulphatase A of other sources with respect to the anomalous time-activity relationship, pI, inhibition by PO42-, SO32- and Ag+ ions and substrate affinity to p-nitrocatechol sulphate. However, the enzyme shows the temperature optimum of arylsulphatase B of other species.  (+info)

Investigation of usefulness of sperm analyses in dogs for male fertility study. (4/35)

The usefulness of sperm analyses in dogs, including sperm motion analysis, was investigated. Sperm motion analysis was performed with the CellSoft-4000 computer-assisted sperm analysis (CASA) system. First, we examined the conditions for preservation of optimal semen quality. We found that sperm retained more of their motility at 4 degrees C than at 37 degrees C. Secondly, we observed sperm motion, concentration and morphology in dog semen continuously for 11 weeks. We collected semen samples during the test period, and the samples retained sperm motion, concentration and morphology. Finally, we administrated alpha-chlorohydrin, which decreases rodent sperm motion, at a single oral dose of 100 mg/kg or 150 mg/kg to dogs. Sperm motion was inhibited immediately after alpha-chlorohydrin treatment, and recovered after 2 weeks. None of the experimental animals were sacrificed in the above-mentioned examinations. We thus confirmed that sperm analyses including motion analysis in dogs are useful in male fertility studies.  (+info)

The effects of alpha-chlorohydrin on the composition of rat and rabbit epididymal plasma: a possible explanation of species difference. (5/35)

The relationship between the antifertility effect of alpha-chlorohydrin and changes in composition of luminal plasma from the cauda epididymidis of rats and rabbits has been investigated. At each dose regimen studied, the fertilizing capacity of rats treated with alpha-chlorohydrin was reduced to zero. The levels of sodium, potassium, glycerylphosphorylcholine (GPC), acid phosphatase and alkaline phosphatase in epididymal plasma were not markedly affected by drug treatment. The most noticeable change was a considerable increase in the concentration of lactic dehydrogenase (LDH) at all dose levels and of glutamic-oxaloacetic transaminase (GOT) after 7 days of treatment with 8 and 16 mg/kg. The effect of cold shock on the composition of epididymal plasma showed that LDH and GOT are, at least in part, derived from spermatozoa. In contrast, alpha-chlorohydrin did not have an antifertility action in the rabbit, and the only notable change in the compositon of epididymal plasma was an increase in the level of GPC. These results provide evidence that, in the rat, alpha-chlorohydrin or a metabolite primarily exerts its antifertility effect by a direct action on the spermatozoa, whilst in the rabbit a barrier may exist to the entrance of the drug into the lumen of the epididymal duct.  (+info)

Inhibition of bull and rabbit sperm enzymes by alpha-chlorohydrin. (6/35)

High concentrations of alpha-chlorohydrin were found to inhibit hyaluronidase, beta-glucuronidase, and aryl sulphatases in bull and rabbit spermatozoa, but not acrosin and neuraminidase. Preincubation of the enzyme and alpha-chlorohydrin was essential to achieve the maximum inhibition which was irreversible.  (+info)

Fertilizing ability in vivo and in vitro of spermatozoa of rats and mice treated with alpha-chlorohydrin. (7/35)

The fertilizing ability of epididymal spermatozoa from rats and mice treated for 3 or 4 or 9 or 10 days with various doses of alpha-chlorohydrin was tested in vitro, and in vivo by intrauterine insemination. The minimum doses (per kg/day) needed to affect fertilization significantly were: rat, in vitro, 8-8 mg for 3 or 4 days, 4-4 mg for 4 days and 2-7 mg for 9 or 10 days; in vivo, 4-4 mg for 3 or 4 days and 2-7 mg for 9 or 10 days: mouse, in vitro, 4-4 mg for 3 days and 13-3 mg for 9 days; in vivo, 44-2 mg for 3 days and 26-5 for 9 days. Rats were infertile for at least 18 days after receiving 44-2 mg alpha-chlorohydrin/kg/day for 3 days, but fertilizing ability, tested in vivo and in vitro, was restored 10-11 days and 15-18 days, respectively, after daily treatment with 11-1 mg alpha-chlorohydrin/kg for 3 days.  (+info)

Resolution and some properties of enzymes involved in enantioselective transformation of 1,3-dichloro-2-propanol to (R)-3-chloro-1,2-propanediol by Corynebacterium sp. strain N-1074. (8/35)

During the course of the transformation of 1,3-dichloro-2-propanol (DCP) into (R)-3-chloro-1,2-propanediol [(R)-MCP] with the cell extract of Corynebacterium sp. strain N-1074, epichlorohydrin (ECH) was transiently formed. The cell extract was fractionated into two DCP-dechlorinating activities (fractions Ia and Ib) and two ECH-hydrolyzing activities (fractions IIa and IIb) by TSKgel DEAE-5PW column chromatography. Fractions Ia and Ib catalyzed the interconversion of DCP to ECH, and fractions IIa and IIb catalyzed the transformation of ECH into MCP. Fractions Ia and IIa showed only low enantioselectivity for each reaction, whereas fractions Ib and IIb exhibited considerable enantioselectivity, yielding R-rich ECH and MCP, respectively. Enzymes Ia and Ib were isolated from fractions Ia and Ib, respectively. Enzyme Ia had a molecular mass of about 108 kDa and consisted of four subunits identical in molecular mass (about 28 kDa). Enzyme Ib was a protein of 115 kDa, composed of two different polypeptides (about 35 and 32 kDa). The specific activity of enzyme Ib for DCP was about 30-fold higher than that of enzyme Ia. Both enzymes catalyzed the transformation of several halohydrins into the corresponding epoxides with liberation of halides and its reverse reaction. Their substrate specificities and immunological properties differed from each other. Enzyme Ia seemed to be halohydrin hydrogen-halide-lyase which was already purified from Escherichia coli carrying a gene from Corynebacterium sp. strain N-1074.  (+info)

In these experiments, TG was used to deplete Ca2+ stores in cells maintained in nominally Ca2+-free extracellular solution. Addition of Ca2+ to the extracellular solution resulted in SOCE-mediated increase in [Ca2+]c (cytosolic Ca2+ concentration) followed by formation of an elevated [Ca2+]c plateau (Figure 4). Addition of InsP3-producing secretagogue ACh reversibly decreased the amplitude of the plateau (Figure 4A, n=465). Using the Mn quench technique [20] we also observed a small (13±2%) but statistically significant inhibition of the influx by 300 nM ACh (Supplementary Figure S5 available at http://www.BiochemJ.org/bj/436/bj4360231add.htm, n=145 cells in ACh-treated group and n=139 cells in control group). Caffeine (10 mM), which in PACs very efficiently blocks InsP3-induced Ca2+ responses [21] has no effect on its own (Figure 4B, n=169), but it partially reversed the ACh-induced reduction of the plateau (Figure 4C, n=168). These experiments suggest that activation of IP3Rs has a mild ...
A comprehensive disposition and metabolism study of epichlorohydrin (ECH) has not been previously reported. In this study, male Fischer 344 rats were dosed (6 mg/kg) orally with [2-14C]ECH (98% radiochemically pure) as an aqueous solution and killed after 3 days. Approximately 38% of the radioactive dose was exhaled as CO2, 50% was excreted as metabolites in the urine, and 3% was present in the feces. Radioactivity in tissues accounted for the remainder of the administered dose. When expressed per gram of tissue, radioactivity was highest in liver, kidney, and forestomach. The half-life of initial elimination of radioactivity in both the urine and exhaled air was about 2 hr, indicating that ECH was rapidly absorbed and metabolized. The major metabolites in the urine were identified as N-acetyl-S-(3-chloro-2-hydroxypropyl)-L-cysteine and alpha-chlorohydrin, about 36 and 4% of the administered dose, respectively. Finding these metabolites, which have not been previously reported, is consistent ...
Background: HER2 amplification is found in 5% of RAS wild type (RASWT) metastatic colorectal cancer (mCRC). Dual HER2 blockade with trastuzumab (T) and lapatinib (L), but not treatment with either drug alone, led to remarkable inhibition of tumor growth in patient-derived tumorgrafts of HER2-amplified mCRC. CRC-specific criteria for HER2 positivity by immunohistochemistry (IHC) and in situ hybridization (ISH) were defined retrospectively in 256 CRC paraffin embedded samples (HERACLES DGX criteria). The ensuing diagnostic algorithm was utilised to screen 1299 HER2-positive tumors for therapeutic targeting in patients in the HERACLES phase 2 trial.. Methods: HERACLES was conducted at 4 Italian centres. Eligibility criteria were: RASWT exon 2, HER2 positivity, refractoriness to standard of care (including cetuximab or panitumumab), PS-ECOG , 1, and measurable. HER2 positivity was defined by IHC and ISH according to HERACLES DGX criteria. Patients (PTS) received T i.v. at 4 mg/kg loading dose ...
C.較高的細胞(柱狀細胞)頂端常有纖毛(cilia)3可藉由拍動來促使精子通過4較矮(立方細胞)的細胞則不具有纖毛(cilia)3但是卻具有微絨毛(microvilli)3可以吸收一部分的睪丸液(testicular fluid ...
An undulating glass roof supported by a branching, tree-like structure houses Westfield Londons 265 shops, food hall, library and more
Castagnoli, E. and Salo, J. and Toivonen, M. S. and Marik, Tamás and Mikkola, R. and Kredics, László (2018) An Evaluation of Boar Spermatozoa as a Biosensor for the Detection of Sublethal and Lethal Toxicity. TOXINS, 10 (11). ISSN 2072-6651 ...
O autor é titular dos direitos autorais dos documentos disponíveis neste repositório e é vedada, nos termos da lei, a comercialização de qualquer espécie sem sua autorização prévia ...
For A Lean Body!Účinná podpora hubnutíRychlejší přenos a spalování tukůDokonale vstřebatelné gelové kapsleTekutý L-karnitin ve snadno polykatelných gelových kap
Edwards, Elizabeth M.; Jones, A. R.; Waites, G. M. H. (May 1975). "The entry of alpha-chlorohydrin into body fluids of male ...
... alpha-chlorohydrin MeSH D02.033.455.706.300 --- chloramphenicol MeSH D02.033.455.706.300.850 --- thiamphenicol MeSH D02.033. ... alpha-chlorohydrin MeSH D02.033.260.220 --- chlorobutanol MeSH D02.033.260.335 --- ethchlorvynol MeSH D02.033.260.350 --- ... ethylene chlorohydrin MeSH D02.033.375.270 --- ethamoxytriphetol MeSH D02.033.375.291 --- ethanolamines MeSH D02.033.375.291. ... 375 --- ethanolamine MeSH D02.033.375.310 --- ethylene chlorohydrin MeSH D02.033.375.534 --- mercaptoethanol MeSH D02.033. ...
The reaction of aqueous hypochlorous acid with alpha-amino acids and dipeptides". Biochimica et Biophysica Acta. 313 (1): 170- ... Winterbourn, CC; Van Den Berg, JJ; Roitman, E; Kuypers, FA (1992). "Chlorohydrin formation from unsaturated fatty acids reacted ... In organic synthesis, HClO converts alkenes to chlorohydrins. In biology, hypochlorous acid is generated in activated ... "Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of ...
Disruption could occur if enough chlorohydrin is formed.[18][24] The addition of preformed chlorohydrin to red blood cells can ... The reaction of aqueous hypochlorous acid with alpha-amino acids and dipeptides". Biochimica et Biophysica Acta. 313 (1): 170- ... In organic synthesis, HClO converts alkenes to chlorohydrins.[5]. *In biology, hypochlorous acid is generated in activated ... The resulting compound is a chlorohydrin.[18] The polar chlorine disrupts lipid bilayers and could increase permeability.[19] ...
This reaction is employed industrially to produce millions of tons of propylene oxide annually from propylene chlorohydrin: ... alpha }CH2Cl}}+KOH}}\ &{\ce {->{\underset {Ethylene}{CH2=CH2}}+{KCl}+H2O}}\\{\ce {{\underset {1-Chloropropane}{CH3-CH2-CH2Cl}}+ ... HF Chlorohydrins, compounds with the connectivity R(HO)CH-CH(Cl)R', undergo dehydrochlorination to give epoxides. ...
Cr2(OAc)4(H2O)2 is used occasionally to dehalogenate organic compounds such as α-bromoketones and chlorohydrins. The reactions ... http://www.molecules.org/coordcpds.html#Cr2OAc4H2O http://alpha.chem.umb.edu/chemistry/ch370/documents/CH371chromiumacetate06. ...
Sicherheitshinweise: P201-P261-P301+P310a-P305+P351+P338-P405-P501a Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. ...
Evaluation of a testicular sperm head counting technique using rats exposed to di methoxyethyl phthalate glycerol alpha mono ... The action of r alpha chlorohydrin and s alpha chlorohydrin and their metabolites on the metabolism of boar sperm. ... The antifertility action of alpha-chlorohydrin: enzyme inhibition by alpha-chlorohydrin phosphate. Experientia 34(10): 1267- ... Mode of action of alpha-chlorohydrin as a male anti-fertility agent. Inhibition of the metabolism of ram spermatozoa by alpha- ...
Book; Format: print ; Literary form: not fiction Publisher: Colombo, Sri Lanka : University of Colombo, 2005Dissertation note: Thesis (Ph.D.)--University of Colombo, 2005. Availability: Items available for loan: WHO HQ [Call number: WC 750 2005KY] (1). ...
... alpha-Chlorohydrin-1-phosphate - Similar structures search, synonyms, formulas, resource links, and other chemical information. ... Substance Name: alpha-Chlorohydrin-1-phosphate. RN: 26807-13-6. UNII: K3VDS5322Z. InChIKey: SQPBDQRPUZEAQD-UHFFFAOYSA-N. Note. ...
ETHYLENE CHLOROHYDRIN. Chloroform. 1003pdf icon. HYDROCARBONS, HALOGENATED. 4-Chloronitrobenzene. 2005pdf icon. NITROAROMATIC ...
Ethylene chlorohydrin. 2513Cdc-pdf. ETHYLENE CHLOROHYDRIN. Ethylenediamine. 2540Cdc-pdf. ETHYLENEDIAMINE, DIETHYLENETRIAMINE ...
Alpha-chlorohydrin-3D-balls.png 1,000 × 610; 146 KB. *. Alpha-Chlorohydrin.svg 338 × 160; 5 KB. ...
Other names: «alpha»-Chlorohydrin; Glycerin «alpha»-monochlorhydrin; Glycerin epichlorohydrin; Glycerol «alpha»-chlorohydrin; ... Glycerol 3-chlorohydrin; Glyceryl «alpha»-chlorohydrin; Glyceryl chloride; U 5897; 1-Chloro-2,3-dihydroxypropane; 1-Chloro-2,3- ... alpha»-monochlorohydrin; «alpha»-Monochlorohydrine; Chlorodeoxyglycerol; 3-Chloro-1,2-dihydroxypropane; 1-Chloropropane-2,3- ... Glycerol chlorohydrin; UN 2689; 3-Chloro-1,2-propylene glycol; 1-Chloro-1-deoxyglycerol; (.+/-.)-2,3-Dihydroxychloropropane; ...
alpha-chlorohydrin. *Applications based on the following class of targets: * Vitamin receptors ...
ALPHA-CHLOROHYDRIN. None. None. None. 0. None. None. None. None. None. None. ...
Alpha-chloroketones *Heteroaromatic compounds *Cyclic ketones *Cyclic alcohols and derivatives *Chlorohydrins *Carboxylic acid ...
Alpha-chlorohydrin. View. View. View. Rodenticide, Chemical intermediate, Solvent, Component of processed f, Industrial ... alpha.-Chloroallyl chloride , 00573 (CA DPR Chem Code Text ) , 029001 [US EPA PC Code, Text ] , 1,3 DICHLOROPROPENE , 1,3- ...
alpha-Chlorohydrin results in decreased expression of NDUFA10 protein. CTD. PMID:26072098. ... NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 Symbol and/or name change. 5135510. APPROVED. ... Ndufa10l1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1) Alliance. DIOPT (Ensembl Compara, Hieranoid, ... 2900053E13Rik; CI-42kD; complex I-42kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10; NADH dehydrogenase [ubiquinone] ...
alpha-Chlorohydrin results in increased expression of SLC16A9 mRNA. CTD. PMID:28522335. ... 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE multiple interactions. ISO. RGD:1347871. 6480464. [testosterone ... 13-BETA-ETHYL-17-ALPHA-ETHYNYL-17-BETA-HYDROXYGON-4-EN-3-ONE (ISO). ...
Edwards, E. M., Jones, A. R., and Waites, G. M. (1975). The entry of alpha-chlorohydrin into body fluids of male rats and its ... and their metabolites alpha-chlorohydrin and epichlorohydrin, and the potent testicular toxicant 1,2-dibromo-3-chloropropane. ... Velisek, J., Davidek, J., Hajslova, J., Kubelka, V., Janicek, G., and Mankova, B. (1978). Chlorohydrins in protein hydrolysates ... Cyanidin-3-O-glucoside protection against TNF-alpha-induced endothelial dysfunction: involvement of nuclear factor-kappaB ...
Edwards, Elizabeth M.; Jones, A. R.; Waites, G. M. H. (May 1975). "The entry of alpha-chlorohydrin into body fluids of male ...
... alpha-chlorohydrin,chlorodeoxyglycerol,glycerol alpha-monochlorohydrin,epibloc,1,2-propanediol, 3-chloro,a-chlorohydrin,3- ... alpha-chlorohydrin,chlorodeoxyglycerol,glycerol alpha-monochlorohydrin,epibloc,1,2-propanediol, 3-chloro,a-chlorohydrin,3- ...
... alpha-chlorohydrin MeSH D02.033.455.706.300 --- chloramphenicol MeSH D02.033.455.706.300.850 --- thiamphenicol MeSH D02.033. ... alpha-chlorohydrin MeSH D02.033.260.220 --- chlorobutanol MeSH D02.033.260.335 --- ethchlorvynol MeSH D02.033.260.350 --- ... ethylene chlorohydrin MeSH D02.033.375.270 --- ethamoxytriphetol MeSH D02.033.375.291 --- ethanolamines MeSH D02.033.375.291. ... 375 --- ethanolamine MeSH D02.033.375.310 --- ethylene chlorohydrin MeSH D02.033.375.534 --- mercaptoethanol MeSH D02.033. ...
Alpha-chlorohydrin and the 6-chloro-6-deoxy sugars had established that ther. e ar. e compounds which could have reversible ...
... alpha-chlorohydrin, heterocyclic agents, and alkylating agents, and delivery systems for antifertility agents is discussed. ...
extra-virgin olive oil, etc ; alpha-chlorohydrin; fatty acids; food purchasing; manufacturing; margarine; markets; palm oils; ... extra-virgin olive oil, etc ; adulterated products; alpha-chlorohydrin; deodorization; esters; refining; temperature; vegetable ...
genetically engineered microorganisms, etc ; Escherichia coli; alpha-chlorohydrin; biotransformation; drying; enzyme activity; ... Coupled fermentation-bioconversion process for production of chiral α-chlorohydrin with recombinant ketoreductase ... Here coupled fermentation-bioconversion process for production of chiral atazanavir intermediate α-chlorohydrin was established ...
The major metabolites in the urine were identified as N-acetyl-S-(3-chloro-2-hydroxypropyl)-L-cysteine and alpha-chlorohydrin, ...
Also lookup: (1) cavanagh harding leigh, (2) cavanagh alpha-chlorohydrin, (3) cavanagh methyl bromide, (4) morgan dl colliculus ...
  • In dogs, humans and rats, one of the metabolites of ornidazole is the C 3 -chloro side-chain of the nitroimidazole ring (6-7) which may produce 3-chlorolactaldehyde and α-chlorohydrin known inhibitors of the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and triosephospahte isomerase (TSI) in spermatozoa (8-9). (ac.ir)
  • To examine the effects of α-chlorohydrin on testis and cauda epididymis in the male house rat ( Rattus rattus ), 24 adult male rats were segregated into two groups. (begellhouse.com)
  • Group I rats were force-fed daily by intragastric intubation with α-chlorohydrin at a single dose of 1.0 mg/100 g body weight/d for 5, 15, and 45 days. (begellhouse.com)
  • We have recently demonstrated that MPO-derived, reactive chlorinating species (RCS) target the vinyl ether bond of tissue plasmalogens resulting in the production of alpha-chloro-fatty aldehyde (alpha-CI-FALD), and unsaturated molecular species of lysophosphatidylcholine (UnsatLPC). (grantome.com)
  • Synergistic inactivation of plasma alpha inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2- dichloroethane. (cdc.gov)