Amanita: A genus of fungi of the family Agaricaceae, order Agaricales; most species are poisonous.Amanitins: Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.Mushroom Poisoning: Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.Alpha-Amanitin: A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER TRANSPLANTATION.RNA Polymerase II: A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.alpha7 Nicotinic Acetylcholine Receptor: A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.Integrin alpha3beta1: Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.Integrin alpha4: An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.Integrin alpha6: An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.Integrin alpha5beta1: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.Integrin alpha4beta1: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.Interleukin-1alpha: An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.Integrin alpha2beta1: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.Receptors, Adrenergic, alpha-1: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.Integrin alpha5: This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.Integrin alpha1beta1: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.Receptors, Adrenergic, alpha-2: A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.Integrin alpha6beta1: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Integrin alpha6beta4: This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.Integrin alpha Chains: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Integrin alpha1: An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.Alpha Rhythm: Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.Integrin alpha3: An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Receptors, Nicotinic: One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.Adrenergic alpha-Agonists: Drugs that selectively bind to and activate alpha adrenergic receptors.

A tunable ratchet driving human RNA polymerase II translocation adjusted by accurately templated nucleoside triphosphates loaded at downstream sites and by elongation factors. (1/38)

When nucleoside triphosphate (NTP) substrates and alpha-amanitin are added to a human RNA polymerase II elongation complex simultaneously, the reaction becomes stalled in the core of the bond synthesis mechanism. The mode of stalling is influenced by NTP substrates at the active site and at downstream sites and by transcription factor IIF (TFIIF) and TFIIS. NTP substrates templated at i+2, i+3, and i+4 downstream DNA sites can reverse the previously stable binding of an NTP loaded at the i+1 substrate site. Deoxy-(d)NTPs and NDPs (nucleoside diphosphates) do not substitute for NTPs at the i+2 and i+3 positions (considered together) or the i+4, i+5, and i+6 positions (considered together). The mode of stalling is altered by changing the number of downstream template sites that are accurately occupied by NTPs and by changing NTP concentration. In the presence of the translocation blocker alpha-amanitin, a steady state condition is established in which RNA polymerase II stably loads an NTP substrate at i+1 and forms a phosphodiester bond but cannot rapidly complete bond synthesis by releasing pyrophosphate. These observations support a role for incoming NTP substrates in stimulating translocation; results appear inconsistent with the secondary pore being the sole route of NTP entry for human RNA polymerase II, and results indicate mechanisms of dynamic error avoidance and error correction during rapid RNA synthesis.  (+info)

Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells. (2/38)

Toxoplasma gondii GRA10 expressed as a GFP-GRA10 fusion protein in HeLa cells moved to the nucleoli within the nucleus rapidly and entirely. GRA10 was concentrated specifically in the dense fibrillar component of the nucleolus morphologically by the overlap of GFP-GRA10 transfection image with IFA images by monoclonal antibodies against GRA10 (Tg378), B23 (nucleophosmin) and C23 (nucleolin). The nucleolar translocalization of GRA10 was caused by a putative nucleolar localizing sequence (NoLS) of GRA10. Interaction of GRA10 with TATA-binding protein associated factor 1B (TAF1B) in the yeast two-hybrid technique was confirmed by GST pull-down assay and immunoprecipitation assay. GRA10 and TAF1B were also co-localized in the nucleolus after co-transfection. The nucleolar condensation of GRA10 was affected by actinomycin D. Expressed GFP-GRA10 was evenly distributed over the nucleoplasm and the nucleolar locations remained as hollows in the nucleoplasm under a low dose of actinomycin D. Nucleolar localizing and interacting of GRA10 with TAF1B suggested the participation of GRA10 in rRNA synthesis of host cells to favor the parasitism of T. gondii.  (+info)

RNA is an integral component of chromatin that contributes to its structural organization. (3/38)

Chromatin structure is influenced by multiples factors, such as pH, temperature, nature and concentration of counterions, post-translational modifications of histones and binding of structural non-histone proteins. RNA is also known to contribute to the regulation of chromatin structure as chromatin-induced gene silencing was shown to depend on the RNAi machinery in S. pombe, plants and Drosophila. Moreover, both in Drosophila and mammals, dosage compensation requires the contribution of specific non-coding RNAs. However, whether RNA itself plays a direct structural role in chromatin is not known. Here, we report results that indicate a general structural role for RNA in eukaryotic chromatin. RNA is found associated to purified chromatin prepared from chicken liver, or cultured Drosophila S2 cells, and treatment with RNase A alters the structural properties of chromatin. Our results indicate that chromatin-associated RNAs, which account for 2%-5% of total chromatin-associated nucleic acids, are polyA(-) and show a size similar to that of the DNA contained in the corresponding chromatin fragments. Chromatin-associated RNA(s) are not likely to correspond to nascent transcripts as they are also found bound to chromatin when cells are treated with alpha-amanitin. After treatment with RNase A, chromatin fragments of molecular weight >3.000 bp of DNA showed reduced sedimentation through sucrose gradients and increased sensitivity to micrococcal nuclease digestion. This structural transition, which is observed both at euchromatic and heterochromatic regions, proceeds without loss of histone H1 or any significant change in core-histone composition and integrity.  (+info)

Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. (4/38)

Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase III (Pol III). Here we address the question of how Pol II coordinates the expression of spliceosome components, including U6. We used chromatin immunoprecipitation (ChIP) and high-resolution mapping by PCR to localize both Pol II and Pol III to snRNA gene regions. We report the surprising finding that Pol II is highly concentrated approximately 300 bp upstream of all five active human U6 genes in vivo. The U6 snRNA, an essential component of the spliceosome, is synthesized by Pol III, whereas all other spliceosomal snRNAs are Pol II transcripts. Accordingly, U6 transcripts were terminated in a Pol III-specific manner, and Pol III localized to the transcribed gene regions. However, synthesis of both U6 and U2 snRNAs was alpha-amanitin-sensitive, indicating a requirement for Pol II activity in the expression of both snRNAs. Moreover, both Pol II and histone tail acetylation marks were lost from U6 promoters upon alpha-amanitin treatment. The results indicate that Pol II is concentrated at specific genomic regions from which it can regulate Pol III activity by a general mechanism. Consequently, Pol II coordinates expression of all RNA and protein components of the spliceosome.  (+info)

The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. (5/38)

 (+info)

Resistance of mitochondrial p53 to dominant inhibition. (6/38)

 (+info)

Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. (7/38)

 (+info)

Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells. (8/38)

 (+info)

*Alpha-Amanitin

... or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, ... Alpha-amanitin is highly active in drug-resistant cells, independent of the status of expression of multi-drug resistant ... "Alpha Amanitin". ADC Review / Journal of Antibody-drug Conjugates. ISSN 2327-0152. Retrieved 26 May 2017. "What are antibody- ... D. Michelot; R. Labia (1988). "alpha-Amanitin: a possible suicide substrate-like toxin involving the sulphoxide moiety of the ...

*Amatoxin

Alpha-amanitin binds to the bridge helix of the RNA Pol II complex and it also binds to part of the complex that is adjacent to ... One study done on mice shows that alpha-Amanitin is not absorbed through skin and therefore can not have any toxic effects. ... 2002). From this crystal structure, it has been determined that alpha-amanitin primarily affects the bridge helix of the RNA ... Chafin, D. R.; Guo, H.; Price, D. H. (1995). "Action of alpha-Amanitin during Pyrophosphorolysis and Elongation by RNA ...

*Mushroom poisoning

Alpha-amanitin: For 6-12 hours, there are no symptoms. This is followed by a period of gastrointestinal upset (vomiting and ... Patients hospitalized and given aggressive support therapy almost immediately after ingestion of amanitin-containing mushrooms ... α-amanitin, the poison produced by the death cap (Amanita phalloides) and others of the genus, is not denatured by heat. " ...

*RNA polymerase II

... is inhibited by α-Amanitin and other amatoxins. Alpha-Amanitin is a highly poisonous substance found in many ... Alpha-Amanitin inhibits RNAP II by strong interactions in the enzyme's "funnel", "cleft", and the key "bridge α-helix" regions ... "The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin". Molecular Cell ... Gong, Xue Q.; Nedialkov, Yuri A.; Burton, Zachary F. (2004-06-25). "α-Amanitin Blocks Translocation by Human RNA Polymerase II ...

*Galerina

Many (though not all) Galerina contain alpha-amanitin and other amatoxins. Galerina steglichii is very rare, bruises blue and ... Klán J. (1993). "Prehled hub obsahujících amanitiny a faloidiny [A review of mushrooms containing amanitins and phalloidines ...

*Amaninamide

It differs from alpha-amanitin in lacking the hydroxyl group on tryptophan. This alters its UV absorption spectrum but not its ...

*Armillaria

Galerina have a dark brown spore print and are deadly poisonous (alpha-amanitin) - see: mushroom poisoning. Honey fungus is a " ...

*Lepiota brunneolilacea

It is known to contain deadly amounts of alpha-Amanitin, and was responsible for a fatal poisoning. Fungi portal List of deadly ...

*Synthetic lethality

POLR2A encodes the catalytic subunit of RNA POLII complex and is susceptible to inhibition by alpha-Amanitin. In colorectal ...

*Amanita citrina

Scientific tests in the University of Cambridge have shown that this mushroom contains the alpha-amanitin toxin.[citation ...

*Oligopeptide

Alpha-amanitin is the main toxin from the species Amanita phalloides, poisonous if ingested by humans or animals. Antipain - An ... Examples of oligopeptides include: Amanitins - Cyclic peptides taken from carpophores of several different mushroom species. ...

*Enzyme inhibitor

An example of a toxic peptide is alpha-amanitin, which is found in relatives of the death cap mushroom. This is a potent enzyme ... alpha K_{m}+\alpha ^{\prime }[S]}}={\frac {(1/\alpha ^{\prime })V_{max}[S]}{(\alpha /\alpha ^{\prime })K_{m}+[S]}}} where the ... alpha =1+{\frac {[I]}{K_{i}}}} α ′ = 1 + [ I ] K i ′ . {\displaystyle \alpha ^{\prime }=1+{\frac {[I]}{K_{i}^{\prime }}}.} Thus ... "Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization ...

*RNA polymerase

Alpha-amanitin Transcription Activators in Eukaryotes Nobel Prize in Chemistry 2006 Griffiths AJF, Miller JH, Suzuki DT, et al ... The beta (β) subunit has a molecular weight of 150,000, beta prime (β′) 160,000, alpha (α) 40,000, and sigma (σ) 70,000. The σ ...

*Patrick Cramer

Bushnell DA, Cramer P, Kornberg RD: Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A ... Bushnell, David A.; Cramer, Patrick; Kornberg, Roger D. (2002-02-05). "Structural basis of transcription: α-Amanitin-RNA ...

*Chemical test in mushroom identification

ISBN 978-0-88902-977-4. Beuhler, M; Lee, DC; Gerkin, R (2004). "The Meixner test in the detection of alpha-amanitin and false- ...

*Piet Borst

Kooter JM, Borst P. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence ...

*Heinrich Otto Wieland

In 1941, Wieland isolated the toxin alpha-amanitin, the principal active agent of one of the world's most poisonous mushrooms ...

*Amanita verna

Just like the death cap, this organism contains a fatal dose of alpha-amanitin, which causes liver failure if not treated ... Fungi portal Amanitin List of Amanita species List of deadly fungi Mushroom poisoning "GSD Species Synonymy: Amanita verna ( ...

*Aucubin

... was found to protect against liver damage induced by carbon tetrachloride or alpha-amanitin in mice and rats when 80 mg ...

*Procyclin

... genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient ...

*Amanita exitialis

Amatoxins content (alpha-amanitin and beta-amanitins especially alpha-amanitin) in the cap, stem or volva of A. exitialis was ... The content and distribution of the main amatoxins (alpha-amanitin, beta-amanitin) and phallotoxins (phallacidin, phallisin, ... Zhang P, Chen Z, Hu J, Wei B, Zhang Z, Hu W (2005). "Production and characterization of Amanitin toxins from a pure culture of ...

*Lepiota brunneoincarnata

It is known to contain deadly amounts of alpha-amanitin and was responsible for a fatal poisoning in Spain in 2002, and for the ... A family in Salon-de-Provence in France was poisoned after mistaking them for the grey knight (Tricholoma terreum). Amanitin ... Intravenous silibinin has a role in reducing amanitin uptake. Other specific measures include penicillin G and n-acetylcysteine ...

*List of biomolecules

... see Alpha-amanitin Amino acid Amylase (also see α-amylase) Anabolic steroid Anethole Angiotensinogen Anisomycin Antidiuretic ... Aequorin Aflatoxin Agar Alamethicin Alanine Albumins Aldosterone Aleurone Alpha-amanitin Allantoin Allethrin α-Amanatin, ...

*Galerina sulciceps

... sulciceps has been shown to contain the toxins known as alpha- (α-), beta- (β-) and gamma- (γ-) amanitins; a series of ... Although these clinical symptoms are inconsistent with those of amatoxin poisoning, the presence of α-, β- and γ- amanitins in ... The survey of fungi containing amanitins and phalloidins]. Časopis Lékařů Českých (in Czech). 132: 449-51. Besl H. (1981). " ... while later studies of toxin concentrations in amanitin-containing mushrooms corroborate this view. The symptoms of poisoning ...

*List of MeSH codes (D12.644)

... gtp-binding protein alpha subunits, g12-g13 MeSH D12.644.360.375.100.200 --- gtp-binding protein alpha subunits, gi-go MeSH ... amanitins MeSH D12.644.456.073 --- angiotensins MeSH D12.644.456.073.021 --- angiotensin i MeSH D12.644.456.073.041 --- ... gtp-binding protein alpha subunits, gq-g11 MeSH D12.644.360.375.100.400 --- gtp-binding protein alpha subunits, gs MeSH D12.644 ... File "2006 MeSH Trees".) MeSH D12.644.050.200 --- defensins MeSH D12.644.050.200.050 --- alpha defensins MeSH D12.644.050.200. ...

*Cyclic peptide

... between the alpha carboxyl of one residue to the alpha amine of another). The smallest such species are 2,5-diketopiperazines, ... Examples include: Amanitins Bacitracin Colistin Ciclosporin Dactinomycin Daptomycin Gramicidin S Hymenistatin Microcystins ... Cyclic isopeptides contain at least one non-alpha amide linkage, such as a linkage between the side chain of one residue to the ... for example in amanitin. Many cyclic peptides have been discovered in nature and many others have been synthesized in the ...
55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Not sure about these fungi. Could be Hygrocybe as they (I think) have colour variation. They are very small as indicated. The area is strewn with felled trees and mainly covered with moss. They seem to appear at the same time every year in the same spot ...
Galerina marginata is a species of poisonous fungus in the family Hymenogastraceae of the order Agaricales. Prior to 2001, the species G. autumnalis, G. oregonensis, G. unicolor, and G. venenata were thought to be separate due to differences in habitat and the viscidity of their caps, but phylogenetic analysis showed that they are all the same species. The fruit bodies of this fungus have brown to yellow-brown caps that fade in color when drying. The gills are brownish and give a rusty spore print. A well-defined membranous ring is typically seen on the stems of young specimens but often disappears with age. In older fruit bodies, the caps are flatter and the gills and stems browner. The species is a classic "little brown mushroom"-a catchall category that includes all small to medium-sized, hard-to-identify brownish mushrooms, and may be easily confused with several edible species. Galerina marginata is widespread in the Northern Hemisphere, including Europe, North America, and Asia, and has ...
Although strongly predictive for mutagenesis, current models have limitations. The RNAP mechanism is complex involving phosphodiester bond synthesis (closed trigger loop), pyrophosphate release (closed→open trigger loop), translocation (open trigger loop), NTP-Mg loading (open→closed trigger loop). Because the bridge helix borders the active site, helix bending and dynamics are likely to influence multiple steps, including catalysis and translocation, and also to influence off pathway steps, such as stalling, pausing, arrest and termination. The current simulations relate most closely to two mechanistic steps, phosphodiester bond synthesis and translocation. Current models are not adequate in their design or duration to address the energetics or kinetics of transitions between steps. The entire RNAP bond addition cycle occurs on a time scale of ~1-50 milliseconds, so the current simulations (10.5 ns) provide limited snapshots of stages of the mechanism. The models give insight into partial ...
Notice to our users== Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email. ==Important small molecule references== *[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem] *[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014] *[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005] ==Alphabetical List of Small Molecules With Literature References== *[[1,3-Dicyclohexylurea]] *[[11-cis retinal]] *[[18alpha-glycyrretinic acid]] *[[2-deoxyadenosine]] *[[2-APB]] *[[2-Deoxyglucose]] *[[3,3,5-triiodothyronine (T3)]] *[[5HT (seratonin)]] *[[8-Pcpt-2-O-Me-cAMP-AM]] *[[activin]] *[[Adenosine, periodate oxidized]] *[[AG1296]] *[[AG1879]] *[[AGN193109]] *[[alpha-amanitin]] ...
Fortunately, cases in which someone eats Galerina on purpose are very rare. The mushroom is not particularly attractive looking and their small size deems them unworthy of gathering for the table. The major danger with Galerina is accidentally and carelessly placing some Galerina fruiting bodies into your collecting basket along with mushrooms they superficially resemble, such as Armillaria gallica, the honey mushroom or Flammulina velutipes, the velvet stem mushroom. Heres the scenario: Sometimes youre lucky (or skilled) and find lots of these edible Armillaria and Flammulina. You find so many that picking them becomes more of a chore than a pleasure. You stop paying attention to every mushroom you place in your basket. You accidentally cut off a Galerina or two or more and place them in with the edible mushrooms. Youre so tired and hungry when you get home that you just dump your mushrooms into a skillet and fry them up. You accidentally eat some Galerina. Two or three days later you die. ...
The IUPHAR/BPS Guide to Pharmacology. amanitin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Click here for galerina fungi pictures! You can also find pictures of frondosa fungi, geastrum fungi, ganoderma fungi, gallica fungi.
Gardening question - Hi, Ive got a quick question about my dracaena marginata .. Ive had it for the last few months, and every time it needed water, I could see the le
Galerina pumila, Dwarf Bell, a poisonous mushroom: identification pictures (images), habitat, edible or poisonous; taxonomy, etymology, synonyms, similar species
Primula marginata produces, early in the season, umbels of 2 to 20, funnel to tubular shaped, lightly fragrant, lavender-blue flowers, 3/4 inch wide, with white-mealy eyes. This rosette-forming evergreen or semi-evergreen perennial has egg-shaped to oblong, leathery, serrated leaves, to 4 inches long. Primroses like
The actin genes of Trypanosoma brucei are transcribed constitutively during the parasite life-cycle, by a polymerase sensitive to alpha-amanitin (1). The start region of the actin gene transcription unit was mapped by virtue of the accumulation of promoter-proximal transcripts which occurs following moderate UV irradiation (2 - 6). This region, located about 4 kilobases upstream from the genes, was able to direct transient expression of the bacterial Chloramphenicol Acetyl Transferase (CAT) gene in both bloodstream and procyclic forms of the parasite. The essential region of the promoter was defined by deletion, and appeared to be within 600 bp upstream from the putative transcription start site. It does not share significant homology with the other trypanosome promoters described so far (VSG, procyclin, rDNA), which all direct alpha-amanitin resistant transcription. ...
Giardia lamblia is an early branching eukaryote, and although distinctly eukaryotic in its cell and molecular biology, transcription and translation in G. lamblia demonstrate important differences from these processes in higher eukaryotes. The cyclic octapeptide amanitin is a relatively selective inhibitor of eukaryotic RNA polymerase II (RNAP II) and is commonly used to study RNAP II transcription. Therefore, we measured the sensitivity of G. lamblia RNAP II transcription to alpha-amanitin and found that unlike most other eukaryotes, RNAP II transcription in Giardia is resistant to 1 mg/ml amanitin. In contrast, 50 microg/ml amanitin inhibits 85% of RNAP III transcription activity using leucyl-tRNA as a template. To better understand transcription in G. lamblia, we identified 10 of the 12 known eukaryotic rpb subunits, including all 10 subunits that are required for viability in Saccharomyces cerevisiae. The amanitin motif (amanitin binding site) of Rpb1 from G. lamblia has amino acid ...
Cortinarius: Spore print rusty brown. Universal and/or partial veil evidence usually present. Spores usually warty; pileipellis a cutis; substantial and interesting cystidia usually lacking.. Galerina: Spore print yellowish brown to rusty brown. Partial veil evidence sometimes present. Spores usually warty; pileipellis a cutis; cheilocystidia usually present. See: Smith, A. H. & Singer, R. (1964). A monograph on the genus Galerina Earle. New York: Hafner. [This monograph treats 199 species of Galerina, most of which meet the description found in couplet 50, above. It relies heavily on microscopic features. An online version of the monograph is available here, at the University of Michigan.. Gymnopilus: Spore print bright orange-brown to bright orange-rusty. Partial veil evidence sometimes present. Taste often bitter. KOH on cap frequently red. Spores warty; pileipellis a cutis; cheilocystidia usually present, often capitate.. Hebeloma: Spore print rusty brown to brown. Partial veil evidence ...
Euphorbia marginata (2012 season) ハツユキソウ(初雪草)の花 英名:Snow-on-the-mountain トウダイグサ科 Euphorbiaceae トウダイグサ属 Euphorbia 白い総苞の中に五つの蜜線と複数の雄蕊の花と一つの雌蕊の花、 トウダイグサ科特有の花の構成ですが、この写真の花には 雌蕊が見当たらず、雄蕊だけの不稔花のよう。(結実率は悪くない) 毎年、前年に採取した種を春に蒔き、発芽率も悪くないのですが、 双葉を食害されて消えてしまうことも多く、 また、育ちもあまり良くないので、来年はある程度大きくなるまで 苗床で育ててみようかと思います。 tags: flowers 花
Very fleshy succulent forms a rosette of lance-shaped, gray-green spiky leaves with spiny, yellow margins that become white with age. Bears a tall flower s
Coremacera marginata (Fabricius) (Dipt. Sciomyzidae) is found in woods, fields, and other terrestrial situations in much of the western Palearctic region. During laboratory rearings through the complete life cycle, each larva killed and ate I-3 immature to adult snails belonging to several terrestrial genera. The immature stages of C. marginata are described and figured, and the distribution is mapped. The taxonomic position of Coremacera is discussed, and a catalog of the genus and new distributional records of 4 rare species of Coremacera are included. A summary chart of the food of sciomyzid larvae is presented.
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Greetings, Damage to the meristematic apex could do it - something that kills the chloroplasts. I dont know whether my plant is genetically variegated or not. Unlike wild plants I have seen with random white streaks in their leaves (which suggests viral infection to me), this plant always has white-edged leaves (variegata marginata). Chlorogalum is related to agave & manfreda and I dont know hoe genetics influences variegation in those plants (which are also frequently variegata marginata). I have selfed two years of seeds and none have come up variegated. But maybe it takes time to emerge and you PBXers will get lucky :-) -,,ipp , Date: Sat, 13 Oct 2012 20:00:19 -0700 , From: [email protected] , To: [email protected] , Subject: Re: [pbs] PBX 326 Chlorogalum and Massonia , , Kipp, , , What is the cause of the variegated foliage then? , , John , , --- On Sat, 10/13/12, Kipp McMichael ,[email protected], wrote: , , From: Kipp McMichael ,[email protected], , Subject: [pbs] PBX 326 ...
Often measures less than 40 mm and at most 56 mm in diameter; large manubrium with 4 very long frilly lips and no gastric peduncle; 4 radial canals, each with curtain-like gonads extending onto "arms" of the manubrium; several prominent centripetal canals extending upward in each quadrant of the ring canal; 600 tentacles; numerous statocysts around the bell margin, each with an indistinct ocellus; milky white umbrella and pink blush around the bell margin (Ref. 2376). ...

Amanita | Article about Amanita by The Free DictionaryAmanita | Article about Amanita by The Free Dictionary

... which contains the heat-stable toxin alpha-amanitin capable of destroying the liver.. Perils of poison control ... The toxicity of death cup is caused by the presence of thermostable toxins-phalloi-dine, α-amanitine, and β-amanitine-which ...
more infohttp://encyclopedia2.thefreedictionary.com/Amanita

Alpha-Amanitin - WikipediaAlpha-Amanitin - Wikipedia

alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, ... Alpha-amanitin is highly active in drug-resistant cells, independent of the status of expression of multi-drug resistant ... "Alpha Amanitin". ADC Review / Journal of Antibody-drug Conjugates. ISSN 2327-0152. Retrieved 26 May 2017. "What are antibody- ... D. Michelot; R. Labia (1988). "alpha-Amanitin: a possible suicide substrate-like toxin involving the sulphoxide moiety of the ...
more infohttps://en.wikipedia.org/wiki/Alpha-Amanitin

Alpha-amanitin | definition of alpha-amanitin by Medical dictionaryAlpha-amanitin | definition of alpha-amanitin by Medical dictionary

... alpha-amanitin explanation free. What is alpha-amanitin? Meaning of alpha-amanitin medical term. What does alpha-amanitin mean? ... Looking for online definition of alpha-amanitin in the Medical Dictionary? ... Alpha-amanitin , definition of alpha-amanitin by Medical dictionary https://medical-dictionary.thefreedictionary.com/alpha- ... medical-dictionary.thefreedictionary.com/alpha-amanitin,alpha-amanitin,/a,. *Facebook ...
more infohttp://medical-dictionary.thefreedictionary.com/alpha-amanitin

The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.  - PubMed - NCBIThe RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. - PubMed - NCBI

... indicating a functional interaction between His1085 and alpha-amanitin that is supported by rerefinement of an alpha-amanitin- ... We propose that alpha-amanitin-inhibited Pol II elongation, which is slow and exhibits reduced substrate selectivity, results ... The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.. Kaplan CD1, ... B. α-amanitin inhibition of 2-dATP usage by wild type Pol II is different than inhibition of NTP usage, while α-amanitin has ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/18538653?dopt=Abstract

alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. | Magdalan | Folia Histochemica et Cytobiologicaalpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. | Magdalan | Folia Histochemica et Cytobiologica

Folia Histochemica et Cytobiologica (FHC) is an international,English-language journal devoted to the developing fields of histochemistry,cytochemistry,cell biology,cell and tissue biology.It is source of the recent research in fields of and cell biology
more infohttps://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4264/3519

ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...

... alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide - Similar structures search, synonyms, formulas, resource links ... Substance Name: alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide. RN: 55325-99-0. InChIKey: GBHLBBPUSBXKSA- ... 4-(2-Mercapto-6-methoxy-L-tryptophan)-alpha-amanitin S-oxide. Systematic Name. *. alpha-Amanitin, 4-(2-mercapto-6-methoxy-L- ...
more infohttps://chem.nlm.nih.gov/chemidplus/rn/55325-99-0

Improved high-performance liquid chromatographic determination with amperometric detection of alpha-amanitin in human plasma...Improved high-performance liquid chromatographic determination with amperometric detection of alpha-amanitin in human plasma...

The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to- ... The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to- ... This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta- ... This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta- ...
more infohttps://iris.univr.it/handle/11562/741

METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION - The Regents of the University of CaliforniaMETHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION - The Regents of the University of California

... alpha amanitin; jasmonic acid; abscisic acid; menadione; cryptogeine; hydrogen peroxide; sodium permanganate; indomethacin; ... For example, a permeant peptide may be derived from the third alpha helix of Drosophila melanogaster transcription factor ... 1988) EMBO J. 17:3793-3805); a myelin basic protein (MBP) promoter; a Ca2+-calmodulin-dependent protein kinase II-alpha (CamKII ... 1988 EMBO J. 17:3793-3805); a myelin basic protein (MBP) promoter; a Ca2+-calmodulin-dependent protein kinase II-alpha (CamKIIα ...
more infohttp://www.freepatentsonline.com/y2018/0044700.html

Haz-Map Category DetailsHaz-Map Category Details

... alpha-Amanitine; alpha-Amatoxin; [ChemIDplus] UN3462 ... alpha-Amanitine; alpha-Amatoxin; [ChemIDplus] UN3462 ...
more infohttps://hazmap.nlm.nih.gov/category-details?id=3581&table=copytblagents

Naturally nasty: the top 10 natural ingredients you need to avoidNaturally nasty: the top 10 natural ingredients you need to avoid

3. Alpha-Amanitin: This is a simple, natural, toxic peptide produced by a mushroom. If you happen to eat some alpha-amanitin ...
more infohttp://thebeautybrains.com/2008/09/naturally-nasty-the-top-10-natural-ingredients-you-need-to-avoid/

Postdoc position availablePostdoc position available

Next message: alpha amanitin for in vivo inhibition * Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] ...
more infohttp://bio.net/bionet/mm/yeast/2000-June/009467.html

A-amanitin | definition of a-amanitin by Medical dictionaryA-amanitin | definition of a-amanitin by Medical dictionary

... a-amanitin explanation free. What is a-amanitin? Meaning of a-amanitin medical term. What does a-amanitin mean? ... Looking for online definition of a-amanitin in the Medical Dictionary? ... alpha-amanitin. (redirected from a-amanitin) α-am·a·ni·tin. (am-ă-nītin), A highly toxic, heat-stable bicyclic oligopeptide in ... a href=https://medical-dictionary.thefreedictionary.com/a-amanitin,alpha-amanitin,/a,. *Facebook ...
more infohttp://medical-dictionary.thefreedictionary.com/a-amanitin

Toxins Art | Fine Art AmericaToxins Art | Fine Art America

Alpha-amanitin Toxin Molecule Laguna Design. $44. Print. E. Coli Stec Bacterial Test ...
more infohttps://fineartamerica.com/art/toxins

RNA Structure And Synthesis  Flashcards by Prachi Patel | BrainscapeRNA Structure And Synthesis Flashcards by Prachi Patel | Brainscape

Alpha- amanitin Inhibits RNA Pol II >>> Pol III not Pol I No mRNA = no protein synthesis = liver failure, death ...
more infohttps://www.brainscape.com/flashcards/rna-structure-and-synthesis-5331674/packs/7951019

Toxic Mushroom-Based Drug May Help Battle Colorectal Cancer | MD
Anderson Cancer CenterToxic Mushroom-Based Drug May Help Battle Colorectal Cancer | MD Anderson Cancer Center

POLR2A encodes an enzyme that is inhibited by alpha-amanitin. We found that suppression of POLR2A with low-dose alpha-amanitin ... For some time, cancer scientists have considered the toxin, alpha-amanitin derived from "death cap" mushrooms, as a possible ... Lus team tested the drug, alpha-amanitin as it was believed that it specifically inhibited POLR2A. ... based on alpha-amanitin as one solution. They found that ADCs, when aimed at a gene called POLR2A, are highly effective in ...
more infohttps://www.mdanderson.org/newsroom/toxic-mushroom-based-drug-may-help-battle-colorectal-cancer.h00-158986656.html

NGS identifies TAZ mutation in a family with X-linked dilated cardiomyopathy.NGS identifies TAZ mutation in a family with X-linked dilated cardiomyopathy.

7898449 - Clustered alpha-amanitin resistance mutations in mouse.. 21667239 - Molecular cloning, promoter analysis, snp ...
more infohttp://www.biomedsearch.com/nih/NGS-identifies-TAZ-mutation-in/23345479.html

Ingestions of environmental toxins - ONAIngestions of environmental toxins - ONA

Alpha-Amanitin is the principal amatoxin responsible for toxicity. These polpeptides are heat stable. Alpha-amanitin absorption ... also appears to facilitate hepatocellular alpha-amanitin uptake. Alpha-amanitin also undergoes enterohepatic recirculation. ... "Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid and ... Silibinin may modify or occupy cell membrane receptor sites and inhibit hepatocellular penetration of alpha-amanitin. A dose of ...
more infohttp://www.oncologynurseadvisor.com/pediatrics/ingestions-of-environmental-toxins/article/622884/

Adventist Youth Honors Answer Book/Nature/Edible Wild Plants - Wikibooks, open books for an open worldAdventist Youth Honors Answer Book/Nature/Edible Wild Plants - Wikibooks, open books for an open world

The most potent toxin present in these mushrooms is alpha-amanitin.. 7. What root plant can be dried and ground into meal?[edit ...
more infohttps://en.wikibooks.org/wiki/Adventist_Youth_Honors_Answer_Book/Nature/Edible_Wild_Plants

Search Results -   - 20 Results - Digital LibrarySearch Results - - 20 Results - Digital Library

The enhanced transcription is not completely inhibited by alpha-amanitin. The value of studying tRNA structure in concert with ...
more infohttps://digital.library.unt.edu/search/?sort=creator&q5=&searchType=advanced&t5=dc_subject&fq=str_degree_department%3ADepartment+of+Biochemistry

Search Results -   - 44 Results - Digital LibrarySearch Results - - 44 Results - Digital Library

The enhanced transcription is not completely inhibited by alpha-amanitin. The value of studying tRNA structure in concert with ... Gas chromatography (GC) in conjunction with mass spectrometry (MS) confirmed production of alpha-eleostearic acid in the ... from Momordica charantia was characterized for production of alpha-eleostearic acid (conjugated double bonds: 18:3 D9 cis, 11 ...
more infohttps://digital.library.unt.edu/explore/partners/UNT/browse/?fq=str_degree_discipline%3ABiochemistry&fq=str_degree_level%3AMaster

Amatoxin - WikipediaAmatoxin - Wikipedia

Alpha-amanitin binds to the bridge helix of the RNA Pol II complex and it also binds to part of the complex that is adjacent to ... One study done on mice shows that alpha-Amanitin is not absorbed through skin and therefore can not have any toxic effects. ... 2002). From this crystal structure, it has been determined that alpha-amanitin primarily affects the bridge helix of the RNA ... Chafin, D. R.; Guo, H.; Price, D. H. (1995). "Action of alpha-Amanitin during Pyrophosphorolysis and Elongation by RNA ...
more infohttps://en.wikipedia.org/wiki/Amatoxin

Vigneron M[au] - PubMed - NCBIVigneron M[au] - PubMed - NCBI

In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Vigneron+M%5Bau%5D&dispmax=50

Liosta Bithmhóilíní - VicipéidLiosta Bithmhóilíní - Vicipéid

α-Amanatin, see Alpha-amanitin. *Aimínaigéad Amino acid. *Séaróideach anabalach Anabolic steroid ...
more infohttps://ga.wikipedia.org/wiki/Liosta_Bithmh%C3%B3ilin%C3%AD

SMART: RPOLD domain annotationSMART: RPOLD domain annotation

Alpha-amanitin inhibited complete RNA polymerase II elongation complex. 2waq. The complete structure of the archaeal 13-subunit ... Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin. ... Crystal Structure of Yeast RNA Polymerase II Complexed with the Inhibitor Alpha Amanitin. ... The alpha subunit (RpoA) initiates RNAP assembly by dimerising to form a platform on which the beta subunits can interact, and ...
more infohttp://smart.embl.de/smart/do_annotation.pl?DOMAIN=RPOLD&START=60&END=339&E_VALUE=4.53e-124&TYPE=SMART&BLAST=TLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDE
  • Amanitin-based ADCs have shown outstanding activity in therapy-resistant tumor cells, e.g. cells expressing multi-drug resistant transporters, tumor-initiating cells and non-dividing cells at picomolar concentrations. (wikipedia.org)
  • These subunits also have unique sequence motifs, especially at their C-terminal ends, which are involved in promoter specificity, for example the CTD of the bacterial RNAP alpha subunit ( IPR011260 ). (embl.de)
  • This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta-amanitin a stronger adsorption for the anodic product was found, which leads to a marked positive shift of the potential required for the oxidation of this isomer in the amperometric detector cell. (univr.it)
  • See "beta-Amanitin. (nih.gov)
  • All three amanitins are oxidized at the same potential values, and adsorption onto the electrode surface of both reactant and products was found in all cases. (univr.it)
  • We found that suppression of POLR2A with low-dose alpha-amanitin stopped cancer cell growth and reduced toxicity. (mdanderson.org)
  • The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to-noise ratio of 2. (univr.it)