OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AmanitaAmanitinsMushroom PoisoningAlpha-AmanitinRNA Polymerase IIalpha 1-AntitrypsinReceptors, Adrenergic, alphaHypoxia-Inducible Factor 1, alpha Subunitalpha7 Nicotinic Acetylcholine ReceptorIntegrin alpha3beta1Integrin alpha4Integrin alpha6Integrin alpha5beta1Integrin alpha4beta1Interleukin-1alphaIntegrin alpha2beta1Receptors, Adrenergic, alpha-1Integrin alpha5Integrin alpha1beta1Receptors, Adrenergic, alpha-2Integrin alpha6beta1Base SequenceIntegrin alpha6beta4Integrin alpha ChainsIntegrinsIntegrin alpha1Alpha RhythmIntegrin alpha3alpha 1-Antitrypsin DeficiencyProtein BindingMolecular Sequence DataReceptors, NicotinicAdrenergic alpha-AgonistsCell Adhesion MoleculesAntibodies, MonoclonalAntigens, NeoplasmCell AdhesionNeural Cell Adhesion MoleculesDibenzothiepinsMaytansineSulfhydryl CompoundsTriazolesDatabases, FactualAnticonvulsantsCarbamazepineEpilepsyValproic AcidPhenytoinSeizuresComparative Effectiveness ResearchConfined SpacesOccupational DiseasesOccupational HealthOccupational Health ServicesToxicologyDatabase Management SystemsOccupational Medicine
Amanita
A genus of fungi of the family Agaricaceae, order Agaricales; most species are poisonous.
Amanitins
Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.
Mushroom Poisoning
Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.
Alpha-Amanitin
A cyclic octapeptide with a thioether bridge between the cystine and tryptophan. It inhibits RNA POLYMERASE II. Poisoning may require LIVER TRANSPLANTATION.
RNA Polymerase II
A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.
alpha 1-Antitrypsin
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
alpha7 Nicotinic Acetylcholine Receptor
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Integrin alpha3beta1
Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.
Integrin alpha4
An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.
Integrin alpha6
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
Integrin alpha5beta1
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Integrin alpha4beta1
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Interleukin-1alpha
An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
Integrin alpha2beta1
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Receptors, Adrenergic, alpha-1
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
Integrin alpha5
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
Integrin alpha1beta1
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
Receptors, Adrenergic, alpha-2
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Integrin alpha6beta1
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Integrin alpha6beta4
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
Integrin alpha Chains
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Integrins
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
Integrin alpha1
An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.
Alpha Rhythm
Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.
Integrin alpha3
An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.
alpha 1-Antitrypsin Deficiency
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Receptors, Nicotinic
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Adrenergic alpha-Agonists
Drugs that selectively bind to and activate alpha adrenergic receptors.
Cell Adhesion Molecules
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Antigens, Neoplasm
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Cell Adhesion
Adherence of cells to surfaces or to other cells.
Neural Cell Adhesion Molecules
Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (ANTIGENS, CD56); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
Dibenzothiepins
Maytansine
An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.
Sulfhydryl Compounds
Compounds containing the -SH radical.
Triazoles
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Anticonvulsants
Drugs used to prevent SEIZURES or reduce their severity.
Carbamazepine
An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Valproic Acid
A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.
Phenytoin
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Comparative Effectiveness Research
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
Confined Spaces
A space which has limited openings for entry and exit combined with unfavorable natural ventilation such as CAVES, refrigerators, deep tunnels, pipelines, sewers, silos, tanks, vats, mines, deep trenches or pits, vaults, manholes, chimneys, etc.
Occupational Diseases
Diseases caused by factors involved in one's employment.
Occupational Health
The promotion and maintenance of physical and mental health in the work environment.
Occupational Health Services
Health services for employees, usually provided by the employer at the place of work.
Toxicology
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
Database Management Systems
Software designed to store, manipulate, manage, and control data for specific uses.
Occupational Medicine
Medical specialty concerned with the promotion and maintenance of the physical and mental health of employees in occupational settings.

A tunable ratchet driving human RNA polymerase II translocation adjusted by accurately templated nucleoside triphosphates loaded at downstream sites and by elongation factors. (1/38)

When nucleoside triphosphate (NTP) substrates and alpha-amanitin are added to a human RNA polymerase II elongation complex simultaneously, the reaction becomes stalled in the core of the bond synthesis mechanism. The mode of stalling is influenced by NTP substrates at the active site and at downstream sites and by transcription factor IIF (TFIIF) and TFIIS. NTP substrates templated at i+2, i+3, and i+4 downstream DNA sites can reverse the previously stable binding of an NTP loaded at the i+1 substrate site. Deoxy-(d)NTPs and NDPs (nucleoside diphosphates) do not substitute for NTPs at the i+2 and i+3 positions (considered together) or the i+4, i+5, and i+6 positions (considered together). The mode of stalling is altered by changing the number of downstream template sites that are accurately occupied by NTPs and by changing NTP concentration. In the presence of the translocation blocker alpha-amanitin, a steady state condition is established in which RNA polymerase II stably loads an NTP substrate at i+1 and forms a phosphodiester bond but cannot rapidly complete bond synthesis by releasing pyrophosphate. These observations support a role for incoming NTP substrates in stimulating translocation; results appear inconsistent with the secondary pore being the sole route of NTP entry for human RNA polymerase II, and results indicate mechanisms of dynamic error avoidance and error correction during rapid RNA synthesis.  (+info)

Nucleolar translocalization of GRA10 of Toxoplasma gondii transfectionally expressed in HeLa cells. (2/38)

Toxoplasma gondii GRA10 expressed as a GFP-GRA10 fusion protein in HeLa cells moved to the nucleoli within the nucleus rapidly and entirely. GRA10 was concentrated specifically in the dense fibrillar component of the nucleolus morphologically by the overlap of GFP-GRA10 transfection image with IFA images by monoclonal antibodies against GRA10 (Tg378), B23 (nucleophosmin) and C23 (nucleolin). The nucleolar translocalization of GRA10 was caused by a putative nucleolar localizing sequence (NoLS) of GRA10. Interaction of GRA10 with TATA-binding protein associated factor 1B (TAF1B) in the yeast two-hybrid technique was confirmed by GST pull-down assay and immunoprecipitation assay. GRA10 and TAF1B were also co-localized in the nucleolus after co-transfection. The nucleolar condensation of GRA10 was affected by actinomycin D. Expressed GFP-GRA10 was evenly distributed over the nucleoplasm and the nucleolar locations remained as hollows in the nucleoplasm under a low dose of actinomycin D. Nucleolar localizing and interacting of GRA10 with TAF1B suggested the participation of GRA10 in rRNA synthesis of host cells to favor the parasitism of T. gondii.  (+info)

RNA is an integral component of chromatin that contributes to its structural organization. (3/38)

Chromatin structure is influenced by multiples factors, such as pH, temperature, nature and concentration of counterions, post-translational modifications of histones and binding of structural non-histone proteins. RNA is also known to contribute to the regulation of chromatin structure as chromatin-induced gene silencing was shown to depend on the RNAi machinery in S. pombe, plants and Drosophila. Moreover, both in Drosophila and mammals, dosage compensation requires the contribution of specific non-coding RNAs. However, whether RNA itself plays a direct structural role in chromatin is not known. Here, we report results that indicate a general structural role for RNA in eukaryotic chromatin. RNA is found associated to purified chromatin prepared from chicken liver, or cultured Drosophila S2 cells, and treatment with RNase A alters the structural properties of chromatin. Our results indicate that chromatin-associated RNAs, which account for 2%-5% of total chromatin-associated nucleic acids, are polyA(-) and show a size similar to that of the DNA contained in the corresponding chromatin fragments. Chromatin-associated RNA(s) are not likely to correspond to nascent transcripts as they are also found bound to chromatin when cells are treated with alpha-amanitin. After treatment with RNase A, chromatin fragments of molecular weight >3.000 bp of DNA showed reduced sedimentation through sucrose gradients and increased sensitivity to micrococcal nuclease digestion. This structural transition, which is observed both at euchromatic and heterochromatic regions, proceeds without loss of histone H1 or any significant change in core-histone composition and integrity.  (+info)

Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. (4/38)

Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase III (Pol III). Here we address the question of how Pol II coordinates the expression of spliceosome components, including U6. We used chromatin immunoprecipitation (ChIP) and high-resolution mapping by PCR to localize both Pol II and Pol III to snRNA gene regions. We report the surprising finding that Pol II is highly concentrated approximately 300 bp upstream of all five active human U6 genes in vivo. The U6 snRNA, an essential component of the spliceosome, is synthesized by Pol III, whereas all other spliceosomal snRNAs are Pol II transcripts. Accordingly, U6 transcripts were terminated in a Pol III-specific manner, and Pol III localized to the transcribed gene regions. However, synthesis of both U6 and U2 snRNAs was alpha-amanitin-sensitive, indicating a requirement for Pol II activity in the expression of both snRNAs. Moreover, both Pol II and histone tail acetylation marks were lost from U6 promoters upon alpha-amanitin treatment. The results indicate that Pol II is concentrated at specific genomic regions from which it can regulate Pol III activity by a general mechanism. Consequently, Pol II coordinates expression of all RNA and protein components of the spliceosome.  (+info)

The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. (5/38)

 (+info)

Resistance of mitochondrial p53 to dominant inhibition. (6/38)

 (+info)

Expression of microRNA processing machinery genes in rhesus monkey oocytes and embryos of different developmental potentials. (7/38)

 (+info)

Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells. (8/38)

 (+info)

talks.cam : Modelling the transcriptional response to ER signalling in breast cancer cellstalks.cam : Modelling the transcriptional response to ER signalling in breast cancer cells
If you have a question about this talk, please contact Florian Markowetz.. We are developing computational models of transcription and its regulation from high-throughput time course data. I will discuss two models: (1) We model RNA polymerase (pol-II) dynamics using data from pol-II ChIP-Seq time course datasets (wa Maina et al. 2014). Our model is used to estimate the elongation speed and promoter activation kinetics for early targets of ER-alpha in MCF7 cells. By clustering the promoter activation profiles we can associate differences in the kinetics with transcription factor binding, e.g. the earliest clusters are all associated with nearby FOXA1 binding. (2) We model the relationship between pol-II dynamics and mRNA production by combining 3 pol-II ChIP-Seq data with RNA -Seq data. We find that 11% of genes where we can fit our model exhibit surprisingly long production delays which appear to be associated with splicing. Although transcription delays are longer than splicing delays for ...
https://talks.cam.ac.uk/talk/index/53532
ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...
55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/55325-99-0
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression. - MRC Weatherall...Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression. - MRC Weatherall...
Spatial/temporal control of Cas9 guide RNA expression could considerably expand the utility of CRISPR-based technologies. Current approaches based on tRNA processing offer a promising strategy but suffer from high background. Here, to address this limitation, we present a screening platform which allows simultaneous measurements of the promoter strength, 5, and 3 processing efficiencies across a library of tRNA variants. This analysis reveals that the sequence determinants underlying these activities, while overlapping, are dissociable. Rational design based on the ensuing principles allowed us to engineer an improved tRNA scaffold that enables highly specific guide RNA production from a Pol-II promoter. When benchmarked against other reported systems this tRNA scaffold is superior to most alternatives, and is equivalent in function to an optimized version of the Csy4-based guide RNA release system. The results and methods described in this manuscript enable avenues of research both in genome
https://www.imm.ox.ac.uk/publications/991313
Galerina marginata - WikipediaGalerina marginata - Wikipedia
Galerina marginata is a species of poisonous fungus in the family Hymenogastraceae of the order Agaricales. Prior to 2001, the species G. autumnalis, G. oregonensis, G. unicolor, and G. venenata were thought to be separate due to differences in habitat and the viscidity of their caps, but phylogenetic analysis showed that they are all the same species. The fruit bodies of this fungus have brown to yellow-brown caps that fade in color when drying. The gills are brownish and give a rusty spore print. A well-defined membranous ring is typically seen on the stems of young specimens but often disappears with age. In older fruit bodies, the caps are flatter and the gills and stems browner. The species is a classic little brown mushroom-a catchall category that includes all small to medium-sized, hard-to-identify brownish mushrooms, and may be easily confused with several edible species. Galerina marginata is widespread in the Northern Hemisphere, including Europe, North America, and Asia, and has ...
https://en.wikipedia.org/wiki/Galerina_marginata
Reaction-based fluorescent sensor for investigating mobile Zn[superscript 2+] in mitochondria of healthy versus cancerous...Reaction-based fluorescent sensor for investigating mobile Zn[superscript 2+] in mitochondria of healthy versus cancerous...
Chelatable, mobile forms of divalent zinc, Zn(II), play essential signaling roles in mammalian biology. A complex network of zinc import and transport proteins has evolved to control zinc concentration and distribution on a subcellular level. Understanding the action of mobile zinc requires tools that can detect changes in Zn(II) concentrations at discrete cellular locales. We present here a zinc-responsive, reaction-based, targetable probe based on the diacetyled form of Zinpyr-1. The compound, (6-amidoethyl)triphenylphosphonium Zinpyr-1 diacetate (DA-ZP1-TPP), is essentially nonfluorescent in the metal-free state; however, exposure to Zn(II) triggers metal-mediated hydrolysis of the acetyl groups to afford a large, rapid, and zinc-induced fluorescence response. DA-ZP1-TPP is insensitive to intracellular esterases over a 2-h period and is impervious to proton-induced turn-on. A TPP unit is appended for targeting mitochondria, as demonstrated by live cell fluorescence imaging studies. The ...
https://dspace.mit.edu/handle/1721.1/89120
View source for Small Molecules for Xenopus Research - XenbaseView source for Small Molecules for Xenopus Research - Xenbase
Notice to our users== Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email. ==Important small molecule references== *[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem] *[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014] *[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005] ==Alphabetical List of Small Molecules With Literature References== *[[1,3-Dicyclohexylurea]] *[[11-cis retinal]] *[[18alpha-glycyrretinic acid]] *[[2-deoxyadenosine]] *[[2-APB]] *[[2-Deoxyglucose]] *[[3,3,5-triiodothyronine (T3)]] *[[5HT (seratonin)]] *[[8-Pcpt-2-O-Me-cAMP-AM]] *[[activin]] *[[Adenosine, periodate oxidized]] *[[AG1296]] *[[AG1879]] *[[AGN193109]] *[[alpha-amanitin]] ...
http://wiki.xenbase.org/xenwiki/index.php?title=Small_Molecules_for_Xenopus_Research&action=edit
amanitin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGYamanitin | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
The IUPHAR/BPS Guide to Pharmacology. amanitin ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=4632
galerina fungi Picturesgalerina fungi Pictures
Click here for galerina fungi pictures! You can also find pictures of frondosa fungi, geastrum fungi, ganoderma fungi, gallica fungi.
http://www.picsearch.com/galerina-fungi-pictures.html
Dracaena Marginata | House Plants for Delivery- Lively RootDracaena Marginata | House Plants for Delivery- Lively Root
The Dracaena Marginata has a unique silhouette and is perfect for filling in spaces in your garden or Green Space! A perfect houseplant for any room!
https://www.livelyroot.com/products/dracaena-margenata
Lomaspilis marginata | Galerie Entomologique - Nicolas SellierLomaspilis marginata | Galerie Entomologique - Nicolas Sellier
Lomaspilis marginata (Linnaeus, 1758) Bordure entrecoupée (La), Marginée (La) - Lomaspilis marginata-St Hilaire La Pallud-01-05-2014 (6).JPG
https://galeriemacro.nsellier.fr/picture.php/448
Mushroom Poisoning | Harvard Catalyst Profiles | Harvard CatalystMushroom Poisoning | Harvard Catalyst Profiles | Harvard Catalyst
In response to Tong TC, et al. Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. Ann Emerg Med. 2008 Aug; 52(2):184-5; author reply 185 ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Mushroom%20Poisoning
Galerina pumila, Dwarf Bell, a toxic toadstoolGalerina pumila, Dwarf Bell, a toxic toadstool
Galerina pumila, Dwarf Bell, a poisonous mushroom: identification pictures (images), habitat, edible or poisonous; taxonomy, etymology, synonyms, similar species
http://www.first-nature.com/fungi/galerina-pumila.php
Primula marginata ( Marginata Primrose ) | Backyard GardenerPrimula marginata ( Marginata Primrose ) | Backyard Gardener
Primula marginata produces, early in the season, umbels of 2 to 20, funnel to tubular shaped, lightly fragrant, lavender-blue flowers, 3/4 inch wide, with white-mealy eyes. This rosette-forming evergreen or semi-evergreen perennial has egg-shaped to oblong, leathery, serrated leaves, to 4 inches long. Primroses like
https://www.backyardgardener.com/plantname/primula-marginata-marginata-primrose/
Glomeris marginata | Semantic ScholarGlomeris marginata | Semantic Scholar
In North Africa, the genus Glomeris is shown to encompass 11 species, all of which are keyed. Th ese include: G. troglokabyliana… Expand ...
https://www.semanticscholar.org/topic/Glomeris-marginata/561419
Explore the ADC component hazards, risks and safety project elements in HPAPIExplore the ADC component hazards, risks and safety project elements in HPAPI
Brief Overview:. SMis global panel of speakers will strengthen your knowledge in key topics such as high potent ingredients, ADC payloads, PK-PD technological advancements, warheads and site selectivity, immune-oncological combination therapies and fragment drug conjugates.. Hear from industry leading pharmaceutical companies and biotechs including Pfizer, Genentech, Seattle Genetics, MedImmune, Janssen, Spirogen and more, who will explore key topics in; new and novel payloads, e.g. Antibody Targeted Amanitin Conjugates (ATACs), principles for maximising the drug delivery efficiency and therapeutic index and using fragment conjugates in order to develop a tailored therapy for solid tumours.. Event Spotlight. The ADC conference will discuss the best ways to approach obstacles faced during different stages of research. While such highly potent compounds can have significant benefits in the treatment of certain medical conditions, they present substantial challenges to the pharmaceutical ...
https://pharmaphorum.com/partner-content/explore-adc-component-hazards-risks-safety-project-elements-hpapi/
The Actin Gene Promoter of Trypanosoma-brucei | DIAL.pr - BOREALThe Actin Gene Promoter of Trypanosoma-brucei | DIAL.pr - BOREAL
The actin genes of Trypanosoma brucei are transcribed constitutively during the parasite life-cycle, by a polymerase sensitive to alpha-amanitin (1). The start region of the actin gene transcription unit was mapped by virtue of the accumulation of promoter-proximal transcripts which occurs following moderate UV irradiation (2 - 6). This region, located about 4 kilobases upstream from the genes, was able to direct transient expression of the bacterial Chloramphenicol Acetyl Transferase (CAT) gene in both bloodstream and procyclic forms of the parasite. The essential region of the promoter was defined by deletion, and appeared to be within 600 bp upstream from the putative transcription start site. It does not share significant homology with the other trypanosome promoters described so far (VSG, procyclin, rDNA), which all direct alpha-amanitin resistant transcription. ...
https://dial.uclouvain.be/pr/boreal/object/boreal:50827
Maxillaria marginata - WikispeciesMaxillaria marginata - Wikispecies
Govaerts, R. et al. 2020. Maxillaria marginata in Kew Science Plants of the World online. The Board of Trustees of the Royal Botanic Gardens, Kew. Published on the internet. Accessed: 2020 Oct 3. Reference page ...
https://species.wikimedia.org/wiki/Maxillaria_marginata
Dracaena marginata Ray of Sunshine Dragon Tree - Aquatopia ConservatoryDracaena marginata Ray of Sunshine Dragon Tree - Aquatopia Conservatory
This beautiful dragon tree will add a pop of colour wherever it is. An added bonus is just how easy it is to care for! Dracaena marginata drah-SEE-na mar-gin-ah-tah Common Names: Madagascar Dragon Tree, Fireworks Plant, Dracaena Cane Family: Dracaenaceae Origin: Africa, Madagascar Growth: Upward
https://aquatopiaplantshop.com/products/dracaena-marginata-ray-of-sunshine
Rhinoptera marginata, Lusitanian cownose ray : fisheriesRhinoptera marginata, Lusitanian cownose ray : fisheries
Found in tropical to warm temperate coastal waters, but absent from islands of western Pacific. Often forming large groups swimming near the surface and quite destructive of commercial oyster and clam beds. Feeds on bottom-living mollusks, crustaceans and fishes. Seldom marketed. Ovoviviparous, gestation period up to one year with 2-6 embryos produced. ...
https://www.fishbase.org/summary/Rhinoptera-marginata.html
Giardia lamblia RNA polymerase II: amanitin-resistant transcription.Giardia lamblia RNA polymerase II: amanitin-resistant transcription.
Giardia lamblia is an early branching eukaryote, and although distinctly eukaryotic in its cell and molecular biology, transcription and translation in G. lamblia demonstrate important differences from these processes in higher eukaryotes. The cyclic octapeptide amanitin is a relatively selective inhibitor of eukaryotic RNA polymerase II (RNAP II) and is commonly used to study RNAP II transcription. Therefore, we measured the sensitivity of G. lamblia RNAP II transcription to alpha-amanitin and found that unlike most other eukaryotes, RNAP II transcription in Giardia is resistant to 1 mg/ml amanitin. In contrast, 50 microg/ml amanitin inhibits 85% of RNAP III transcription activity using leucyl-tRNA as a template. To better understand transcription in G. lamblia, we identified 10 of the 12 known eukaryotic rpb subunits, including all 10 subunits that are required for viability in Saccharomyces cerevisiae. The amanitin motif (amanitin binding site) of Rpb1 from G. lamblia has amino acid ...
http://vivo.mblwhoilibrary.org/display/publication22422
23: Euphorbia marginata (2012 season) - juria23: Euphorbia marginata (2012 season) - juria
Euphorbia marginata (2012 season) ハツユキソウ(初雪草)の花 英名：Snow-on-the-mountain トウダイグサ科 Euphorbiaceae トウダイグサ属 Euphorbia 白い総苞の中に五つの蜜線と複数の雄蕊の花と一つの雌蕊の花、 トウダイグサ科特有の花の構成ですが、この写真の花には 雌蕊が見当たらず、雄蕊だけの不稔花のよう。(結実率は悪くない) 毎年、前年に採取した種を春に蒔き、発芽率も悪くないのですが、 双葉を食害されて消えてしまうことも多く、 また、育ちもあまり良くないので、来年はある程度大きくなるまで 苗床で育ててみようかと思います。 tags: flowers 花
http://www.23hq.com/juria/photo/8009637
Agave americana ( Marginata Century Plant ) | Backyard GardenerAgave americana ( Marginata Century Plant ) | Backyard Gardener
Very fleshy succulent forms a rosette of lance-shaped, gray-green spiky leaves with spiny, yellow margins that become white with age. Bears a tall flower s
https://www.backyardgardener.com/plantname/agave-americana-marginata-century-plant/
The Forgotten Savannas of Western Victoria: Population Dynamics of Tree-form Silver Banksia (Banksia marginata) in a Severely...The Forgotten Savannas of Western Victoria: Population Dynamics of Tree-form Silver Banksia (Banksia marginata) in a Severely...
The Forgotten Savannas of Western Victoria: Population Dynamics of Tree-form Silver Banksia (Banksia marginata) in a Severely Fragmented Landscape
https://opal.latrobe.edu.au/articles/thesis/The_Forgotten_Savannas_of_Western_Victoria_Population_Dynamics_of_Tree-form_Silver_Banksia_Banksia_marginata_in_a_Severely_Fragmented_Landscape_/12950774/2
Category:Dracaena marginata - Wikimedia CommonsCategory:Dracaena marginata - Wikimedia Commons
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. ...
https://commons.wikimedia.org/wiki/Category:Dracaena_marginata
Search Results - | PHSA LibrariesSearch Results - | PHSA Libraries
This title is licensed for one user at a time on BC Cancer-network computers. If you are denied access while on a network computer, try again later ...
https://libraries.phsa.ca/bcca/list?q=&p=1&ps=&sort=title_sort+asc&name_facet=Abraham%2C+Jame
Marginated tortoise - WikipediaMarginated tortoise - Wikipedia
The marginated tortoise was formally described by German naturalist Johann David Schoepff in 1789; its specific epithet marginata is a straightforward derivation from the Latin term for marginated. The nominate subspecies is the Greek marginated tortoise, Testudo marginata marginata. Three additional subspecies of marginated tortoises have been named: The Sardinian marginated tortoise (T. m. sarda) is the name usually used to separate the population on the island of Sardinia. These tortoises have less strongly bent tiles in the posterior of their carapaces, and the posterior of the carapace is almost smooth compared with the saw-like T. m. marginata. Clearly distinct according to morphology and entirely allopatric, it cannot be distinguished by mtDNA cytochrome b and nDNA ISSR sequence analysis.[3] Lineage sorting has not occurred to a considerable degree; consequently, the more geographically isolated Sardinian population is presumably of quite recent origin. Indeed, it appears to derive from ...
https://en.wikipedia.org/wiki/Marginated_tortoise
Eradication of Phytophthora cinnamomi from infested Eucalyptus marginata (jarrah) forest during large scale mining operations ...Eradication of Phytophthora cinnamomi from infested Eucalyptus marginata (jarrah) forest during large scale mining operations ...
2014) Eradication of Phytophthora cinnamomi from infested Eucalyptus marginata (jarrah) forest during large scale mining operations. In: 7th International Union of Research Organisations. IUFRO Working Party 7-02-09, Phytophthora in Forests and Natural Ecosystems, 9 - 14th November, Esquel, Argentina. ...
https://researchrepository.murdoch.edu.au/id/eprint/33420/
PBX 326 Chlorogalum and MassoniaPBX 326 Chlorogalum and Massonia
Greetings, Damage to the meristematic apex could do it - something that kills the chloroplasts. I dont know whether my plant is genetically variegated or not. Unlike wild plants I have seen with random white streaks in their leaves (which suggests viral infection to me), this plant always has white-edged leaves (variegata marginata). Chlorogalum is related to agave & manfreda and I dont know hoe genetics influences variegation in those plants (which are also frequently variegata marginata). I have selfed two years of seeds and none have come up variegated. But maybe it takes time to emerge and you PBXers will get lucky :-) -,,ipp , Date: Sat, 13 Oct 2012 20:00:19 -0700 , From: [email protected] , To: [email protected] , Subject: Re: [pbs] PBX 326 Chlorogalum and Massonia , , Kipp, , , What is the cause of the variegated foliage then? , , John , , --- On Sat, 10/13/12, Kipp McMichael ,[email protected], wrote: , , From: Kipp McMichael ,[email protected], , Subject: [pbs] PBX 326 ...
http://www.pacificbulbsociety.org/pbslist/2012-October/afkk444k61kqicgbgh1ncn7kn6.html
Maeotias marginataMaeotias marginata
Often measures less than 40 mm and at most 56 mm in diameter; large manubrium with 4 very long frilly lips and no gastric peduncle; 4 radial canals, each with curtain-like gonads extending onto arms of the manubrium; several prominent centripetal canals extending upward in each quadrant of the ring canal; 600 tentacles; numerous statocysts around the bell margin, each with an indistinct ocellus; milky white umbrella and pink blush around the bell margin (Ref. 2376). ...
http://sealifebase.ca/summary/Maeotias-marginata.html
RNA polymeraseRNA polymerase
Alpha-amanitin Primase Werner F, Grohmann D (February 2011). "Evolution of multisubunit RNA polymerases in the three domains of ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, ...
https://en.wikipedia.org/wiki/RNA_polymerase
AmatoxinAmatoxin
Alpha-amanitin (α-Amanitin) primarily affects the bridge helix of the RNA pol II complex, a highly conserved domain 35 amino ... This test sensitively detects alpha-amanitin and gamma-amanitin (clearly detects 10 ng/mL), and exhibits slightly less ... Alpha-amanitin binds to the bridge helix of the RNA Pol II complex and it also binds to part of the complex that is adjacent to ... One study done on mice shows that alpha-Amanitin is not absorbed through skin and therefore can not have any toxic effects. ...
https://en.wikipedia.org/wiki/Amatoxin
Mushroom poisoningMushroom poisoning
Alpha-amanitin: For 6-12 hours, there are no symptoms. This is followed by a period of gastrointestinal upset (vomiting and ... Patients hospitalized and given aggressive support therapy almost immediately after ingestion of amanitin-containing mushrooms ... α-amanitin, the poison produced by the death cap (Amanita phalloides) and others of the genus, is not denatured by heat. " ...
https://en.wikipedia.org/wiki/Mushroom_poisoning
GalerinaGalerina
Many (though not all) Galerina contain alpha-amanitin and other amatoxins. Galerina steglichii is very rare, bruises blue and ... Klán J. (1993). "Prehled hub obsahujících amanitiny a faloidiny [A review of mushrooms containing amanitins and phalloidines ...
https://en.wikipedia.org/wiki/Galerina
Amanita citrinaAmanita citrina
It has been shown that this mushroom contains the alpha-amanitin toxin. However, the amounts of this toxin were found to be ...
https://en.wikipedia.org/wiki/Amanita_citrina
AmaninamideAmaninamide
It differs from alpha-amanitin in lacking the hydroxyl group on tryptophan. This alters its UV absorption spectrum but not its ...
https://en.wikipedia.org/wiki/Amaninamide
ArmillariaArmillaria
Galerina have a dark brown spore print and are deadly poisonous (alpha-amanitin) - see: mushroom poisoning. Honey fungus is a " ...
https://en.wikipedia.org/wiki/Armillaria
Lepiota brunneolilaceaLepiota brunneolilacea
It is known to contain deadly amounts of alpha-Amanitin, and was responsible for a fatal poisoning. List of deadly fungi List ...
https://en.wikipedia.org/wiki/Lepiota_brunneolilacea
RNA polymerase IIRNA polymerase II
Alpha-Amanitin inhibits RNAP II by strong interactions in the enzyme's "funnel", "cleft", and the key "bridge α-helix" regions ... RNA polymerase II is inhibited by α-Amanitin and other amatoxins. α-Amanitin is a highly poisonous substance found in many ... "The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin". Molecular Cell ... Gong, Xue Q.; Nedialkov, Yuri A.; Burton, Zachary F. (2004-06-25). "α-Amanitin Blocks Translocation by Human RNA Polymerase II ...
https://en.wikipedia.org/wiki/RNA_polymerase_II
OligopeptideOligopeptide
Alpha-amanitin is the main toxin from the species Amanita phalloides, poisonous if ingested by humans or animals. Antipain - An ... Examples of oligopeptides include: Amanitins - Cyclic peptides taken from carpophores of several different mushroom species. ...
https://en.wikipedia.org/wiki/Oligopeptide
Enzyme inhibitorEnzyme inhibitor
An example of a toxic peptide is alpha-amanitin, which is found in relatives of the death cap mushroom. This is a potent enzyme ... alpha K_{m}+\alpha ^{\prime }[S]}}={\frac {(1/\alpha ^{\prime })V_{max}[S]}{(\alpha /\alpha ^{\prime })K_{m}+[S]}}} where the ... alpha =1+{\frac {[I]}{K_{i}}}} α ′ = 1 + [ I ] K i ′ . {\displaystyle \alpha ^{\prime }=1+{\frac {[I]}{K_{i}^{\prime }}}.} Thus ... "Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization ...
https://en.wikipedia.org/wiki/Enzyme_inhibitor
Chemical test in mushroom identificationChemical test in mushroom identification
ISBN 978-0-88902-977-4. Beuhler, M; Lee, DC; Gerkin, R (2004). "The Meixner test in the detection of alpha-amanitin and false- ...
https://en.wikipedia.org/wiki/Chemical_test_in_mushroom_identification
Piet BorstPiet Borst
Kooter JM, Borst P. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence ...
https://en.wikipedia.org/wiki/Piet_Borst
Heinrich Otto WielandHeinrich Otto Wieland
In 1941, Wieland isolated the toxin alpha-amanitin, the principal active agent of one of the world's most poisonous mushrooms ...
https://en.wikipedia.org/wiki/Heinrich_Otto_Wieland
Amanita vernaAmanita verna
Just like the death cap, this organism contains a fatal dose of alpha-amanitin, which causes liver failure if not treated ... Fungi portal Amanitin List of Amanita species List of deadly fungi Mushroom poisoning "GSD Species Synonymy: Amanita verna ( ...
https://en.wikipedia.org/wiki/Amanita_verna
Drosophila quinaria species groupDrosophila quinaria species group
... such as ibotenic acid and alpha-amanitin. Mushroom sites also host a number of natural enemies. For instance, as a consequence ... Bowman DD (November 2011). "Introduction to the alpha-proteobacteria: Wolbachia and Bartonella, Rickettsia, Brucella, Ehrlichia ...
https://en.wikipedia.org/wiki/Drosophila_quinaria_species_group
AucubinAucubin
... was found to protect against liver damage induced by carbon tetrachloride or alpha-amanitin in mice and rats when 80 mg ...
https://en.wikipedia.org/wiki/Aucubin
ProcyclinProcyclin
... genes located in an unusually small alpha-amanitin-resistant transcription unit: PARP promoter activity assayed by transient ...
https://en.wikipedia.org/wiki/Procyclin
Peptide bondPeptide bond
Some peptides, like alpha-amanitin, are called ribosomal peptides as they are made by ribosomes, but many are nonribosomal ... alpha }-C^{\prime }-N-C^{\alpha }} ) is denoted ω {\displaystyle \omega } ; ω = 0 ∘ {\displaystyle \omega =0^{\circ }} for the ... A peptide bond is an amide type of covalent chemical bond linking two consecutive alpha-amino acids from C1 (carbon number one ... of one alpha-amino acid and N2 (nitrogen number two) of another, along a peptide or protein chain. It can also be called an ...
https://en.wikipedia.org/wiki/Peptide_bond
Liosta Bithmhóilíní - VicipéidLiosta Bithmhóilíní - Vicipéid
α-Amanatin, see Alpha-amanitin. *Aimínaigéad Amino acid. *Séaróideach anabalach Anabolic steroid ...
https://ga.wikipedia.org/wiki/Liosta_Bithmhóiliní
Amanita exitialisAmanita exitialis
Amatoxins content (alpha-amanitin and beta-amanitins especially alpha-amanitin) in the cap, stem or volva of A. exitialis was ... The content and distribution of the main amatoxins (alpha-amanitin, beta-amanitin) and phallotoxins (phallacidin, phallisin, ... Zhang P, Chen Z, Hu J, Wei B, Zhang Z, Hu W (2005). "Production and characterization of Amanitin toxins from a pure culture of ...
https://en.wikipedia.org/wiki/Amanita_exitialis
Lepiota brunneoincarnataLepiota brunneoincarnata
It is known to contain deadly amounts of alpha-amanitin and was responsible for a fatal poisoning in Spain in 2002, and a ... A family in Salon-de-Provence in France was poisoned after mistaking them for the grey knight (Tricholoma terreum). Amanitin ... Intravenous silibinin has a role in reducing amanitin uptake. Other specific measures include penicillin G and n-acetylcysteine ...
https://en.wikipedia.org/wiki/Lepiota_brunneoincarnata
List of biomoleculesList of biomolecules
Aequorin Aflatoxin Agar Alamethicin Alanine Albumins Aldosterone Aleurone Alpha-amanitin Alpha-MSH (Melaninocyte stimulating ... see Alpha-amanitin Amino acid Amylase (also see α-amylase) Anabolic steroid Anandamide (ANA) Androgen Anethole Angiotensinogen ...
https://en.wikipedia.org/wiki/List_of_biomolecules
Galerina sulcicepsGalerina sulciceps
More toxic than the deathcap (Amanita phalloides), G. sulciceps has been shown to contain the toxins alpha- (α-), beta- (β-) ... Although these clinical symptoms are inconsistent with those of amatoxin poisoning, the presence of α-, β- and γ- amanitins in ... and gamma- (γ-) amanitin; a series of poisonings in Indonesia in the 1930s resulted in 14 deaths from the consumption of this ... The survey of fungi containing amanitins and phalloidins]. Časopis Lékařů Českých (in Czech). 132: 449-51. Besl H. (1981). " ...
https://en.wikipedia.org/wiki/Galerina_sulciceps
Alpha-AmanitinAlpha-Amanitin
... or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, ... Early methods to detect alpha-amanitin included thin-layer chromatography (TLC). In most solvent systems used in TLC, alpha- ... Brüggemann O, Meder M, Freitag R (September 1996). "Analysis of amatoxins alpha-amanitin and beta-amanitin in toadstool ... Alpha-amanitin is highly active in drug-resistant cells, independent of the status of expression of multi-drug resistant ...
https://en.wikipedia.org/wiki/Alpha-Amanitin
Botulinum toxinBotulinum toxin
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ...
https://en.wikipedia.org/wiki/Botulinum
Cardiotoxin IIICardiotoxin III
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ...
https://en.wikipedia.org/wiki/Cardiotoxin_III
HistrionicotoxinsHistrionicotoxins
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ...
https://en.wikipedia.org/wiki/Histrionicotoxin
California newtCalifornia newt
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ...
https://en.wikipedia.org/wiki/California_Newt
Toxin tiếng ViệtToxin tiếng Việt
Aflatoxin · Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin) · Citrinin · Cytochalasin · Ergotamine · ... Clostridium: tetani (Tetanospasmin) · perfringens (Alpha toxin, Enterotoxin) · difficile (A, B) · botulinum (Botox). khác: ... nhện: Latrotoxin (Alpha-latrotoxin) · Stromatoxin · PhTx3. Động vật thân mềm: Conotoxin · Eledoisin · Onchidal · Saxitoxin ... bò sát/nọc độc rắn: Bungarotoxin (Alpha-Bungarotoxin, Beta-Bungarotoxin) · Calciseptine · Taicatoxin · Calcicludine · ...
https://vi.wikipedia.org/wiki/Toxin
MuscarineMuscarine
... poisoning is characterized by miosis, blurred vision, increased salivation, excessive sweating, lacrimation, bronchial secretions, bronchoconstriction, bradycardia, abdominal cramping, increased gastric acid secretion, diarrhea and polyuria. If muscarine reaches the brain it can cause tremor, convulsions and hypothermia. Cardiac ventricles contain muscarinic receptors that mediate a decrease in the force of contractions leading to a lower blood pressure. If muscarine is administered intravenously, muscarine can trigger acute circulatory failure with cardiac arrest.[1] The symptoms of intoxication with mushrooms rich in muscarine, especially Inocybe, are very typical: The symptoms start early, after one-quarter to two hours, with headache, nausea, vomiting, and constriction of the pharynx. Then salivation, lacrimation, and diffuse perspiration set in, combined with miosis, disturbed accommodation, and reduced vision. Gastric and small bowel colic leads to diarrhea, and there is a ...
https://en.wikipedia.org/wiki/Muscarine
Neurotoksin Bahasa Melayu, ensiklopedia bebasNeurotoksin Bahasa Melayu, ensiklopedia bebas
Aflatoksin · Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin) · Citrinin · Cytochalasin · Ergotamine ... Clostridium: tetani (Tetanospasmin) · perfringens (Toksin alpha, Enterotoxin) · difficile (A, B) · botulinum (Botox). lain: ... reptilia/bisa ular: Bungarotoksin (Alpha-Bungarotoksin, Beta-Bungarotoksin) · Calciseptine · Taicatoxin · Calcicludine · ... Streptolisin · Leukosidin (Panton-Valentine leukosidin) · Stafilokokus (Staphylococcus aureus alpha/beta/delta, Exfoliatin, ...
https://ms.wikipedia.org/wiki/Neurotoksin
Heat-labile enterotoxinHeat-labile enterotoxin
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ... It acts similarly to the cholera toxin by raising cAMP levels through ADP-ribosylation of the alpha-subunit of a Gs protein ...
https://en.wikipedia.org/wiki/Heat-labile_enterotoxin
টক্সিন - উইকিপিডিয়াটক্সিন - উইকিপিডিয়া
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ...
https://bn.wikipedia.org/wiki/টক্সিন
TetanospasminTetanospasmin
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ... These inhibitory neurotransmitters inhibit the alpha motor neurons. With diminished inhibition, the resting firing rate of the ... alpha motor neuron increases, producing rigidity, unopposed muscle contraction and spasm. Characteristic features are risus ...
https://en.wikipedia.org/wiki/Tetanospasmin
Cholera toxinCholera toxin
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ... The CTA1 fragment catalyses ADP-ribosylation of the Gs alpha subunit (Gαs) proteins using NAD. The ADP-ribosylation causes the ... forms an extended alpha helix which sits snugly in the central pore of the B subunit ring.[6] ...
https://en.wikipedia.org/wiki/Cholera_toxin
鏈球菌溶血素 - 维基百科，自由的百科鏈球菌溶血素 - 维基百科，自由的百科
毒傘肽 (α-鵝膏蕈鹼, beta-amanitin（英语：Beta-Amanitin）, gamma-amanitin（英语：Gamma-Amanitin）, epsilon-amanitin（英语：Epsilon-Amanitin）) ... Staphylococcus aureus alpha（英语：Staphylococcus aureus alpha toxin）/beta（英语：Staphylococcus aureus beta toxin）/delta（英语： ...
https://zh.wikipedia.org/wiki/鏈球菌溶血素
Enzyme inhibitorEnzyme inhibitor
An example of a toxic peptide is alpha-amanitin, which is found in relatives of the death cap mushroom. This is a potent enzyme ... displaystyle V={\frac {V_{max}[S]}{\alpha K_{m}+\alpha ^{\prime }[S]}}={\frac {(1/\alpha ^{\prime })V_{max}[S]}{(\alpha /\alpha ... displaystyle \alpha =1+{\frac {[I]}{K_{i}}}}. α. ′. =. 1. +. [. I. ]. K. i. ′. .. {\displaystyle \alpha ^{\prime }=1+{\frac {[I ... "Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization ...
https://en.wikipedia.org/wiki/Enzyme_inhibition
CharybdotoxinCharybdotoxin
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ... Compared with other therapies like alpha blockers it has a relatively short recovery period (10 vs 16-42 hours).[10] ...
https://en.wikipedia.org/wiki/Charybdotoxin
LipopolysaccharideLipopolysaccharide
Amatoxin (alpha-amanitin, beta-amanitin, gamma-amanitin, epsilon-amanitin). *beta-Nitropropionic acid ... "Lipopolysaccharide-binding protein plasma levels and liver TNF-alpha gene expression in obese patients: evidence for the ...
https://en.wikipedia.org/wiki/Lipopolysaccharide
Cyclic peptideCyclic peptide
... between the alpha carboxyl of one residue to the alpha amine of another). The smallest such species are 2,5-diketopiperazines, ... Examples include: Amanitins Bacitracin Colistin Ciclosporin Dactinomycin Daptomycin Gramicidin S Hymenistatin Microcystins ... Cyclic isopeptides contain at least one non-alpha amide linkage, such as a linkage between the side chain of one residue to the ... for example in amanitin. Many cyclic peptides have been discovered in nature and many others have been synthesized in the ...
https://en.wikipedia.org/wiki/Cyclic_peptide
Alpha-Amanitin - WikipediaAlpha-Amanitin - Wikipedia
alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, ... Early methods to detect alpha-amanitin included thin-layer chromatography (TLC). In most solvent systems used in TLC, alpha- ... Brüggemann O, Meder M, Freitag R (September 1996). "Analysis of amatoxins alpha-amanitin and beta-amanitin in toadstool ... Alpha-amanitin is highly active in drug-resistant cells, independent of the status of expression of multi-drug resistant ...
https://en.wikipedia.org/wiki/Alpha-Amanitin
The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. - PubMed - NCBIThe RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. - PubMed - NCBI
... indicating a functional interaction between His1085 and alpha-amanitin that is supported by rerefinement of an alpha-amanitin- ... We propose that alpha-amanitin-inhibited Pol II elongation, which is slow and exhibits reduced substrate selectivity, results ... The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin.. Kaplan CD1, ... B. α-amanitin inhibition of 2-dATP usage by wild type Pol II is different than inhibition of NTP usage, while α-amanitin has ...
https://www.ncbi.nlm.nih.gov/pubmed/18538653?dopt=Abstract
AMA - Alpha-amanitin proprotein precursor - Amanita fuliginea (East Asian brown death cap) - AMA gene & proteinAMA - Alpha-amanitin proprotein precursor - Amanita fuliginea (East Asian brown death cap) - AMA gene & protein
3R,4R)-4,5-dihydroxyisoleucine; in form alpha-amanitinBy similarity. Manual assertion inferred from sequence similarity toi ... Alpha-amanitinBy similarity. Manual assertion inferred from sequence similarity toi ... Alpha-amanitin proprotein1 Publication. Manual assertion based on opinion ini ... sp,A0A023IWG4,AAMAT_AMAFU Alpha-amanitin proprotein OS=Amanita fuliginea OX=67708 GN=AMA PE=3 SV=1 ...
https://www.uniprot.org/uniprot/A0A023IWG4
Alpha-amanitin | definition of alpha-amanitin by Medical dictionaryAlpha-amanitin | definition of alpha-amanitin by Medical dictionary
... alpha-amanitin explanation free. What is alpha-amanitin? Meaning of alpha-amanitin medical term. What does alpha-amanitin mean? ... Looking for online definition of alpha-amanitin in the Medical Dictionary? ... Alpha-amanitin , definition of alpha-amanitin by Medical dictionary https://medical-dictionary.thefreedictionary.com/alpha- ... medical-dictionary.thefreedictionary.com/alpha-amanitin,alpha-amanitin,/a,. *Facebook ...
http://medical-dictionary.thefreedictionary.com/alpha-amanitin
alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. | Magdalan | Folia Histochemica et Cytobiologicaalpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. | Magdalan | Folia Histochemica et Cytobiologica
Folia Histochemica et Cytobiologica (FHC) is an international,English-language journal devoted to the developing fields of histochemistry,cytochemistry,cell biology,cell and tissue biology.It is source of the recent research in fields of and cell biology
https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/4264/3519
Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum ...Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum ...
Alpha-Amanitin / toxicity* * Animals * Apoptosis / drug effects * Aspartate Aminotransferases / blood * Chemical and Drug ... This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA ... on α-Amanitin-Induced Liver Injury in Mice Int J Med Mushrooms. 2016;18(9):841-850. doi: 10.1615/IntJMedMushrooms.v18.i9.80. ...
https://pubmed.ncbi.nlm.nih.gov/27910775/
Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic...Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic...
This preclinical study suggests that anti-EpCAM antibody conjugates with α-amanitin have the potential to be highly effective ... Alpha-Amanitin / immunology * Alpha-Amanitin / pharmacology* * Angiogenesis Inhibitors / pharmacology * Animals * Antibodies, ... chiHEA125-Ama [n = 6 mice], dose of 15 mg/kg with respect to IgG and 50 μg/kg with respect to α-amanitin, mean relative ... Conclusion: This preclinical study suggests that anti-EpCAM antibody conjugates with α-amanitin have the potential to be highly ...
https://pubmed.ncbi.nlm.nih.gov/22457476/
A-amanitin | definition of a-amanitin by Medical dictionaryA-amanitin | definition of a-amanitin by Medical dictionary
... a-amanitin explanation free. What is a-amanitin? Meaning of a-amanitin medical term. What does a-amanitin mean? ... Looking for online definition of a-amanitin in the Medical Dictionary? ... alpha-amanitin. (redirected from a-amanitin) α-am·a·ni·tin. (am-ă-nītin), A highly toxic, heat-stable bicyclic oligopeptide in ... a href=https://medical-dictionary.thefreedictionary.com/a-amanitin,alpha-amanitin,/a,. *Facebook ...
http://medical-dictionary.thefreedictionary.com/a-amanitin
METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION - The Regents of the University of CaliforniaMETHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION - The Regents of the University of California
... alpha amanitin; jasmonic acid; abscisic acid; menadione; cryptogeine; hydrogen peroxide; sodium permanganate; indomethacin; ... For example, a permeant peptide may be derived from the third alpha helix of Drosophila melanogaster transcription factor ... 1988) EMBO J. 17:3793-3805); a myelin basic protein (MBP) promoter; a Ca2+-calmodulin-dependent protein kinase II-alpha (CamKII ... 1988 EMBO J. 17:3793-3805); a myelin basic protein (MBP) promoter; a Ca2+-calmodulin-dependent protein kinase II-alpha (CamKIIα ...
http://www.freepatentsonline.com/y2018/0044700.html
RRP6L1 and RRP6L2 Function in Silencing Regulation of Antisense RNA Synthesis | proLékaře.czRRP6L1 and RRP6L2 Function in Silencing Regulation of Antisense RNA Synthesis | proLékaře.cz
Alpha-amanitin treatment. Eleven-day-old seedlings were treated with 5 µM α-amanitin (Sigma) for 0, 6 and 9 h or 17 h. After ... α-amanitin treatment was performed for 0, 6 and 9 hours. The expression of antisense transcript was normalized to ACTIN 7. ... Therefore, we used the rrp6l1-1 single mutant and conducted an α-amanitin chase to compare the rates of ASL transcript decay in ... We did not detect ASL in plants treated with α-amanitin (Fig. 3D), implying that RNA Pol II synthesizes ASL. To confirm this, ...
https://www.prolekare.cz/casopisy/plos-genetics/2014-9/rrp6l1-and-rrp6l2-function-in-silencing-regulation-of-antisense-rna-synthesis-54965
ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...ChemIDplus - 55325-99-0 - GBHLBBPUSBXKSA-AGOVMNPFSA-N - alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide -...
... alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide - Similar structures search, synonyms, formulas, resource links ... Substance Name: alpha-Amanitin, 4-(2-mercapto-6-methoxy-L-tryptophan)-, S-oxide. RN: 55325-99-0. InChIKey: GBHLBBPUSBXKSA- ... 4-(2-Mercapto-6-methoxy-L-tryptophan)-alpha-amanitin S-oxide. Systematic Name. *. alpha-Amanitin, 4-(2-mercapto-6-methoxy-L- ...
https://chem.nlm.nih.gov/chemidplus/rn/55325-99-0
Inhibition of initiation of DNA replication in Drosophila by alpha-amanitin & its possible significance. | Indian J Exp Biol;...Inhibition of initiation of DNA replication in Drosophila by alpha-amanitin & its possible significance. | Indian J Exp Biol;...
Inhibition of initiation of DNA replication in Drosophila by alpha-amanitin & its possible significance. ... Inhibition of initiation of DNA replication in Drosophila by alpha-amanitin & its possible ... Amanitins/pharmacology , Animals , DNA Replication/drug effects , Depression, Chemical , Drosophila melanogaster , Female ... Amanitins / Animals Language: English Journal: Indian J Exp Biol Year: 1977 Type: Article ...
https://search.bvsalud.org/gim/resource/en/sea-60065
In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity | Journal of The Korean Society of...In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity | Journal of The Korean Society of...
Alpha-amanitin (α-amanitin) is a major toxin from extremely poisonous Amanita fungi. Oxidative stress, which may contribute to ... Alpha-Amanitin , Amanita , Antioxidants , Antipyretics , Apiaceae , Calcium Channels , Carcinoma, Hepatocellular , Cell Line , ... In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity ... In vitro Protective Effects of Glehnia Littoralis on Alpha-amanitin Induced Hepatotoxicity ...
https://search.bvsalud.org/gim/resource/en/wprim-121672
Alpha-amanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine: Further...Alpha-amanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine: Further...
Alpha-amanitin was shown to inhibit triiodothyronine (T3)-induced increases in mitochondrial alpha-glycerophosphate ... N2 - Alpha-amanitin was shown to inhibit triiodothyronine (T3)-induced increases in mitochondrial alpha-glycerophosphate ... AB - Alpha-amanitin was shown to inhibit triiodothyronine (T3)-induced increases in mitochondrial alpha-glycerophosphate ... abstract = "Alpha-amanitin was shown to inhibit triiodothyronine (T3)-induced increases in mitochondrial alpha-glycerophosphate ...
https://einstein.pure.elsevier.com/en/publications/alpha-amanitin-administration-results-in-a-temporary-inhibition-o-2
Improved high-performance liquid chromatographic determination with amperometric detection of alpha-amanitin in human plasma...Improved high-performance liquid chromatographic determination with amperometric detection of alpha-amanitin in human plasma...
The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to- ... The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to- ... This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta- ... This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta- ...
https://iris.univr.it/handle/11562/741
VACWR029 - Protein N2 - Vaccinia virus (strain Western Reserve) (VACV) - VACWR029 gene & proteinVACWR029 - Protein N2 - Vaccinia virus (strain Western Reserve) (VACV) - VACWR029 gene & protein
Alpha-amanitin target. COWPX. 178. CPXV038 protein. CWPXB. 177. Uncharacterized protein. Orthopoxvirus Abatino ...
https://www.uniprot.org/uniprot/P14357
RNA Structure And Synthesis Flashcards by Prachi Patel | BrainscapeRNA Structure And Synthesis Flashcards by Prachi Patel | Brainscape
Alpha- amanitin Inhibits RNA Pol II >>> Pol III not Pol I No mRNA = no protein synthesis = liver failure, death ...
https://www.brainscape.com/flashcards/rna-structure-and-synthesis-5331674/packs/7951019
MEDLINE - Resultado p gina 1 MEDLINE - Resultado p gina 1
0 (Alpha-Amanitin); 0 (Antidotes); 0 (Silicates); 16291-96-6 (Charcoal); 1J444QC288 (Amlodipine); 33CM23913M (Carbamazepine); ... Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D03.383.742.698.253.650
Postdoc position availablePostdoc position available
Next message: alpha amanitin for in vivo inhibition * Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] ...
http://bio.net/bionet/mm/yeast/2000-June/009467.html
Haz-Map Category DetailsHaz-Map Category Details
... alpha-Amanitine; alpha-Amatoxin; [ChemIDplus] UN3462 ... alpha-Amanitine; alpha-Amatoxin; [ChemIDplus] UN3462 ...
https://hazmap.nlm.nih.gov/category-details?id=3581&table=copytblagents
Toxic Mushroom-Based Drug May Help Battle Colorectal Cancer | MD Anderson Cancer CenterToxic Mushroom-Based Drug May Help Battle Colorectal Cancer | MD Anderson Cancer Center
POLR2A encodes an enzyme that is inhibited by alpha-amanitin. We found that suppression of POLR2A with low-dose alpha-amanitin ... For some time, cancer scientists have considered the toxin, alpha-amanitin derived from "death cap" mushrooms, as a possible ... Lus team tested the drug, alpha-amanitin as it was believed that it specifically inhibited POLR2A. ... based on alpha-amanitin as one solution. They found that ADCs, when aimed at a gene called POLR2A, are highly effective in ...
https://www.mdanderson.org/newsroom/toxic-mushroom-based-drug-may-help-battle-colorectal-cancer.h00-158986656.html
RNA polymerase - WikipediaRNA polymerase - Wikipedia
Alpha-amanitin Primase Werner F, Grohmann D (February 2011). "Evolution of multisubunit RNA polymerases in the three domains of ... RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, ...
https://en.wikipedia.org/wiki/RNA_polymerase
Naturally nasty: the top 10 natural ingredients you need to avoidNaturally nasty: the top 10 natural ingredients you need to avoid
3. Alpha-Amanitin: This is a simple, natural, toxic peptide produced by a mushroom. If you happen to eat some alpha-amanitin ...
http://thebeautybrains.com/2008/09/naturally-nasty-the-top-10-natural-ingredients-you-need-to-avoid/
Vigneron M[au] - PubMed - NCBIVigneron M[au] - PubMed - NCBI
In vivo degradation of RNA polymerase II largest subunit triggered by alpha-amanitin. ...
https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Vigneron+M%5Bau%5D&dispmax=50
Adventist Youth Honors Answer Book/Nature/Edible Wild Plants - Wikibooks, open books for an open worldAdventist Youth Honors Answer Book/Nature/Edible Wild Plants - Wikibooks, open books for an open world
The most potent toxin present in these mushrooms is alpha-amanitin.. 7. What root plant can be dried and ground into meal?[edit ...
https://en.wikibooks.org/wiki/Adventist_Youth_Honors_Answer_Book/Nature/Edible_Wild_Plants
Toxins Art | Fine Art AmericaToxins Art | Fine Art America
Alpha-amanitin Toxin Molecule Laguna Design. $44. Print. E. Coli Stec Bacterial Test ...
https://fineartamerica.com/art/toxins
The Basic Principles of Critical Care Nephrology - Nova Science PublishersThe Basic Principles of Critical Care Nephrology - Nova Science Publishers
... alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. Folia Histochem. Cytobiol., 48, 58-62. [46] Massoumi, G ... acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin. Exp. Toxicol. Pathol., 62, 367- ...
https://novapublishers.com/shop/the-basic-principles-of-critical-care-nephrology/?add_to_wishlist=15137
In Vitro Analysis of α-Amanitin-Resistant Transcription from the rRNA, Procyclic Acidic Repetitive Protein, and Variant Surface...In Vitro Analysis of α-Amanitin-Resistant Transcription from the rRNA, Procyclic Acidic Repetitive Protein, and Variant Surface...
Alpha-amanitin resistant transcription of protein coding genes in insect and bloodstream form Trypanosoma brucei.EMBO J. 8 1989 ... Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site ... Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous ... Effect of α-amanitin on PARP-trm, VSG-trm, and Rib-trm transcription. In vitro transcription reactions were carried out in the ...
https://mcb.asm.org/content/19/8/5466?ijkey=bec8a4dc53034fba85dd8273cb1653801ae62217&keytype2=tf_ipsecsha
Search Results - - 20 Results - Digital LibrarySearch Results - - 20 Results - Digital Library
The enhanced transcription is not completely inhibited by alpha-amanitin. The value of studying tRNA structure in concert with ...
https://digital.library.unt.edu/search/?sort=creator&q5=&searchType=advanced&t5=dc_subject&fq=str_degree_department%3ADepartment+of+Biochemistry
ToxinAmanitaGenesInhibitionInhibitorBeta-amanitinTranscriptionConjugatesAmatoxinsApoptosisADCsBicyclicResistantActinomycinHepatocytesToxinsSensitivityCycloheximideMushroomsConcentrationsDrosophila2018AmatoxinInhibitsToxicityPolymerase IIMRNAElongationLiverHepaticEnzymeAminoUrineSubstancesVitroDetectionCellsToxicComparativeSubunitEffectsMethods
Toxin12
  • α-Amanitin is a selective inhibitor of RNA polymerase II and III but not I. This mechanism makes it a deadly toxin. (wikipedia.org)
  • In most solvent systems used in TLC, alpha-amanitin and beta-amanitin would travel at different rates, thus allowing individual identification of each toxin. (wikipedia.org)
  • Doctors called a mycologist who questioned the patient and identified the mushroom as the aptly named "death angel," or Amanita bisporigera, which contains the heat-stable toxin alpha-amanitin capable of destroying the liver. (thefreedictionary.com)
  • Chemical cross-linking was conducted to covalently conjugate α-amanitin, a toxin known to inhibit DNA transcription, with chiHEA125, a chimerized anti-EpCAM monoclonal antibody, to generate the antibody-drug conjugate α-amanitin-glutarate-chiHEA125 (chiHEA125-Ama). (nih.gov)
  • Alpha-amanitin (α-amanitin) is a major toxin from extremely poisonous Amanita fungi. (bvsalud.org)
  • A sensitive and simple method is described for the selective determination in human plasma of alpha-amanitin, the most poisonous and prevalent toxin in the lethal fungi of species Amanita, using high-performance liquid chromatography with amperometric detection. (univr.it)
  • For some time, cancer scientists have considered the toxin, alpha-amanitin derived from "death cap" mushrooms, as a possible cancer treatment. (mdanderson.org)
  • In Trypanosoma brucei , transcription resistant to the mushroom toxin α-amanitin is not restricted to the rRNA genes (rDNA), as in higher eukaryotes, but extends to genes encoding the major cell surface proteins variant surface glycoprotein (VSG) and procyclin or procyclic acidic repetitive protein (PARP). (asm.org)
  • At least 5 subtypes of amatoxins are known, the only significant human toxin being alpha-amatoxin, which inhibits RNA polymerase II and protein synthesis. (medscape.com)
  • In sum, our results indicate there are no direct effects of eating α-amanitin on this host-parasite interaction, and we suggest that toxin tolerance is more likely maintained by selection due to competition for resources than as a mechanism to avoid parasite infection or to reduce the virulence of infection. (unboundmedicine.com)
  • The mushroom toxin α-amanitin binds Pol II and inhibits transcription at the step of RNA chain elongation. (divbiolchem.org)
  • Our work provides the structural basis for the inhibition of mammalian Pol II by the natural toxin α-amanitin and highlights that cryo-EM is well suited to studying interactions of a small molecule with its macromolecular target. (divbiolchem.org)
Amanita5
  • Piqueras J. Concentración de amatoxinas en ejemplares de Amanita phalloides (Vaill. (springer.com)
  • Amanitins occur in the extremely poisonous toadstools such as Amanita phalloides (death cap), Amanita verna (white death cap), Amanita virosa (destroying angel) and other Amanita species. (buhlmannlabs.ch)
  • The detection of alpha-Amanitin (100 %) and gamma-Amanitin (90 %) in urine using the BÜHLMANN Amanitin ELISA confirms Amanita intoxication. (buhlmannlabs.ch)
  • Silymarin has been shown to reverse the effects of highly toxic alkaloids, such phalloidine and [[alpha]]-amanitine from the Avenging Angel mushroom ( Amanita phalloides ) as well as protect liver cells from their impact. (healthy.net)
  • epsilon-Amanitin is one of a group of at least eight Amatoxins found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some Conocybe, Galerina and Lepiota mushroom species. (t3db.ca)
Genes3
  • The genes encoding the proprotein for α-amanitin belong to the same family as those that encode for phallacidin (a phallotoxin). (wikipedia.org)
  • One outstanding finding was that transcription of these genes is, in contrast to most other protein-coding genes of T. brucei , resistant to α-amanitin, a characteristic of RNA polymerase I (Pol I)-mediated transcription ( 9 , 21 , 32 ). (asm.org)
  • Key genes in regulation of transcription, chromatin-structure cell adhesion, and signal transduction were up-regulated at the 8-cell stage as compared with 8-cell embryos treated with alpha-amanitin and MII. (rti.org)
Inhibition4
  • Amino acid substitutions within the Pol II TL preferentially alter substrate usage and enzyme fidelity, as does inhibition of transcription by alpha-amanitin. (nih.gov)
  • Inhibition of initiation of DNA replication in Drosophila by alpha-amanitin & its possible significance. (bvsalud.org)
  • After the initial inhibition of enzyme induction by alphaamanitin was dissipated, however, a delayed but striking increase in enzyme activity occurred. (elsevier.com)
  • Oppenheimer, Jack H. / Alpha-amanitin administration results in a temporary inhibition of hepatic enzyme induction by triiodothyronine : Further evidence favoring a long-lived mediator of thyroid hormone action . (elsevier.com)
Inhibitor3
  • Time-lapse video recording and cytogenetic analysis were used to determine the sensitivity of NIH3T3 cells to the RNA polymerase II inhibitor alpha-amanitin at different stages of the cell cycle. (biomedsearch.com)
  • Dave has continued his structural studies of RNA polymerase II mechanism including solving the structure of RNA Polymerase II with the inhibitor alpha-amanitin. (stanford.edu)
  • The necrotic cell death (or Type III cell death in the category by Schweichel and Merker) [ 15 ] was induced by the RNA-polymerase inhibitor, α-amanitin, and suppressed by new isoforms of YAP [ 3 , 8 ] that interacts with transcription factor TEAD or p73 as a critical mediator of Hippo signaling pathway. (biomedcentral.com)
Beta-amanitin2
  • This adsorption did not affect the signal recorded for alpha- and gamma-amanitins at the amperometric detector, and for beta-amanitin a stronger adsorption for the anodic product was found, which leads to a marked positive shift of the potential required for the oxidation of this isomer in the amperometric detector cell. (univr.it)
  • See "beta-Amanitin. (nih.gov)
Transcription7
  • Here, we report the development of a homologous cell extract from procyclic T. brucei cells in which rDNA and PARP A and VSG gene promoters drive efficient, accurate, and α-amanitin-resistant transcription. (asm.org)
  • 2002. Structural basis of transcription: alpha-Amanitin-RNA polymerase II cocrystal at 2.8 Ã… resolution . (cornell.edu)
  • This suggests that cells exposed to alpha-amanitin are able to complete their cell cycle because sufficiently high levels of mRNA are present in S/G2 due to basal level transcription, or are left from preceding cell cycles. (biomedsearch.com)
  • Transcription of T-DNA in Octopine and Nopaline Crown Gall Tumors Is Inhibited by Low Concentrations of Alpha-Amanitin. (mpg.de)
  • The findings of this study demonstrate that direct hepatotoxicity of TNF-alpha is associated with an apoptotic mechanism that becomes manifest under the metabolic condition of arrested transcription and functional translation. (jimmunol.org)
  • We have compared NGF-mediated TH and AChE induction and have provided pharmacological evidence that TH induction involves a post-transcriptional, polyadenylation-dependent event (blockable by 9-beta-arabinofuranosyladenine but not by alpha- amanitin), whereas AChE induction requires transcription (blockable by alpha-amanitin). (jneurosci.org)
  • Host cell involvement in Sindbis virus (SB) replication was examined in cells which had been treated with either actinomycin D (AMD) or alpha-amanitin (alpha-A). Treatment with these inhibitors of host transcription before infection reduced the ability of cells to support SB growth by 1 to 2 orders of magnitude, while having little or no effect on the replication of vesicular stomatitis virus. (asm.org)
Conjugates8
  • This preclinical study suggests that anti-EpCAM antibody conjugates with α-amanitin have the potential to be highly effective therapeutic agents for pancreatic carcinomas and various EpCAM-expressing malignancies. (nih.gov)
  • The contract has been signed in an effort to develop a novel class of antibody drug conjugates that will be based on Heidelberg Pharma's patented technology to integrate a-Amanitin to antibodies. (thefreedictionary.com)
  • Researchers at The University of Texas MD Anderson Cancer Center looked at antibody drug conjugates (ADCs) based on alpha-amanitin as one solution. (mdanderson.org)
  • Heidelberg Pharma, a subsidiary of Wilex, has signed an exclusive multi-target research agreement with Takeda Pharmaceutical Company for the joint development of antibody-drug conjugates that use amanitin as the payload. (adcreview.com)
  • Antibody Targeted Amanitin Conjugates or ATACs are ADCs whose active ingredient is made up of amatoxin molecules. (adcreview.com)
  • In 2012 researchers at the Department of Translational Immunology of the German Cancer Research Center generated an anti-EpCAM antibody conjugates with α-amanitin. (adcreview.com)
  • Their pre-clinical results confirmed the potential of an anti-EpCAM antibody conjugates with α-amanitin to be highly effective therapeutic agents for pancreatic carcinomas and various EpCAM-expressing malignancies. (adcreview.com)
  • Under the terms of the exclusive multi-target research agreement, Heidelberg Pharma will produce Antibody Targeted Amanitin Conjugates (ATACs) using antibodies from Takeda's proprietary portfolio for up to three undisclosed targets. (adcreview.com)
Amatoxins1
  • As early as the 1980s, antibody-based assays (immunoassays) were developed for amanitin (but more often recognize amatoxins as the antibodies cross-react with some of the congeners). (wikipedia.org)
Apoptosis2
  • alpha-Amanitin induced apoptosis in primary cultured dog hepatocytes. (viamedica.pl)
  • Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. (jimmunol.org)
ADCs1
  • Amanitin-based ADCs with an improved therapeutic index. (xsite.live)
Bicyclic2
  • RNA polymerase I is insensitive, RNA polymerase II is highly sensitive (inhibited at 1μg/ml), RNA polymerase III is moderately sensitive (inhibited at 10μg/ml), and RNA polymerase IV is slightly sensitive (inhibited at 50μg/ml).[citation needed] α-amanitin is a highly modified bicyclic octapeptide consisting of an outer and an inner loop. (wikipedia.org)
  • The main toxic actions are caused by Amanitins, which are bicyclic octapeptides. (buhlmannlabs.ch)
Resistant7
  • Finally, substitution of His1085 in the TL specifically renders Pol II highly resistant to alpha-amanitin, indicating a functional interaction between His1085 and alpha-amanitin that is supported by rerefinement of an alpha-amanitin-Pol II crystal structure. (nih.gov)
  • Using an alpha-amanitin-resistant polymerase, we provide evidence that promoter- proximal pausing does not require the carboxy-terminal domain of the polymerase. (xenbase.org)
  • Alpha-amanitin-resistant D. melanogaster with an altered RNA polymerase II. (xenbase.org)
  • One form was totally resistant to alpha-amanitin, whereas the second was 50% inhibited by 10-20 micrograms of the drug/ml. (portlandpress.com)
  • The amanitin-resistant enzyme, polymerase R, was partially purified by chromatography on CM-Sephadex, DEAE-Sephadex and heparin-Sepharose. (portlandpress.com)
  • Alpha-amanitin is highly active in drug-resistant cells, independent of the status of expression of multi-drug resistant transporters because of its hydrophilic structure. (xsite.live)
  • SB replication was sensitive to alpha-A in wild-type Chinese hamster ovary (CHO) cells but was resistant to alpha-A in CHOama-1 cells, a line which contains an alpha-A-resistant RNA polymerase II. (asm.org)
Actinomycin2
  • We found that protein synthesis inhibitors, such as anisomycin or emetine, and RNA synthesis inhibitors, such as actinomycin D or alpha-amanitin, blocked long-term facilitation without interferring with short-term facilitation. (elsevier.com)
  • However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had been pretreated with the transcriptional inhibitors actinomycin D (ActD), D-galactosamine, or alpha-amanitin. (jimmunol.org)
Hepatocytes1
  • Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity. (jimmunol.org)
Toxins3
  • 1 Such mechanisms may mediate hepatoprotective properties against liver toxins such as carbon tetrachloride and alpha-amanitin. (sigmaaldrich.com)
  • Retrieved from " https: At the molecular level amanitin toxins cause damage to cells of these organs. (xsite.live)
  • Protective effects of phytosomal silybin were observed using rats pre-exposed to toxins such as praseodymium, galactosamine, and the mushroom poisons phalloidin and alpha-amanitin. (lexico.com)
Sensitivity3
  • This is done by testing the sensitivity of the polymerase in the presence of α-amanitin. (wikipedia.org)
  • Mutant Caenorhabditis elegans RNA polymerase II with a 20,000-fold reduced sensitivity to alpha-amanitin. (genetics.org)
  • In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. (cathdb.info)
Cycloheximide1
Mushrooms2
  • If you happen to eat some alpha-amanitin laced mushrooms you'll feel cramps & diarrhea within 24 hours. (thebeautybrains.com)
  • The lethality of a few mushrooms underlines the importance of the Amanitin ELISA offered by BÜHLMANN. (buhlmannlabs.ch)
Concentrations1
  • Polymerase S, sensitive to low alpha-amanitin concentrations, was more extensively purified, with an 18% recovery, and yielded a single major band with two minor ones after native gel electrophoresis. (portlandpress.com)
Drosophila1
  • As mushroom-feeding Drosophila can tolerate deadly mycotoxins, but their Howardula nematode parasites cannot, we asked how consuming the potent mycotoxin α-amanitin has affected this host-parasite interaction. (unboundmedicine.com)
20181
  • devised strategies to surmount three synthetic hurdles to give α-amanitin in 2018. (wikipedia.org)
Amatoxin2
  • Alpha-amatoxin is rapidly absorbed by the GI tract, has limited protein binding, and may undergo enterohepatic recirculation. (medscape.com)
  • Chemical structure of the amatoxin alpha-amanitin. (adcreview.com)
Inhibits2
  • Moreover, EspH selectively inhibits the tumor necrosis factor alpha (TNF-α)-induced Erk signaling pathway. (stanford.edu)
  • The colchicine also inhibits the production of tumor necrosis factor alpha (TNFα) which is synthesised by macrophages and down-regulates the expression of TNFα-receptor on the surface of macrophages and endothelial cells and this shows symptoms of anti-inflammatory activity (Hinkley & Green 1971). (ukessays.com)
Toxicity1
  • We found that suppression of POLR2A with low-dose alpha-amanitin stopped cancer cell growth and reduced toxicity. (mdanderson.org)
Polymerase II4
  • In addition, α-amanitin is decorated with modified amino acid side chains (2S,3R,4R)-4,5-dihydroxy-isoleucine, trans-4-hydroxy-proline, which gives its high affinity for RNA polymerase II and III. (wikipedia.org)
  • α-Amanitin has an unusually strong and specific attraction to the enzyme RNA polymerase II. (wikipedia.org)
  • The RNA polymerase II trigger loop functions in substrate selection and is directly targeted by alpha-amanitin. (nih.gov)
  • It has different requirements for cations and salts than RNA polymerase II and III and is not inhibited by alpha-amanitin. (harvard.edu)
MRNA1
  • The half-life of Penk mRNA levels (about 12 h), however, seems not to be affected by histamine as suggested by measurement of the subsequent decay of Penk mRNA levels after addition of .alpha. (eurekamag.com)
Elongation2
  • We propose that alpha-amanitin-inhibited Pol II elongation, which is slow and exhibits reduced substrate selectivity, results from direct alpha-amanitin interference with the TL. (nih.gov)
  • Here, we present the high-resolution cryo-EM structure of α-amanitin bound to and inhibited by its natural target, the mammalian Pol II elongation complex. (divbiolchem.org)
Liver3
  • Determination of alpha-amanitin in serum and liver by multistage linear ion trap mass spectrometry. (thefreedictionary.com)
  • This study evaluated the hepatoprotective effects of triterpenoids from G. lucidum on liver injury induced by a-amanitin (α-AMA) in mice and the mechanisms of action of these triterpenoids, including radical scavenging and antiapoptosis activities. (nih.gov)
  • Jahn W, Faulstich H, Wieland T. Pharmacokinetics of ( 3 H-)Methyl-Dehydroxy-Methyl- α -Amanitin in the isolated perfused rat liver. (springer.com)
Hepatic1
  • In the in vitro model, Glehnia littoralis was effective in limiting hepatic injury after α-amanitin poisoning. (bvsalud.org)
Enzyme5
  • Alpha-amanitin was shown to inhibit triiodothyronine (T 3 )-induced increases in mitochondrial alpha-glycerophosphate dehydrogenase (α-GPD) and cytoplasmic malic enzyme activity in the livers of male Sprague-Dawley rats. (elsevier.com)
  • Similarly, alpha-amanitin blocked a two-to four-fold increase in malic enzyme 24 h following iv injection of 3 mg T 3 /IOO g BW into euthyroid rats. (elsevier.com)
  • In euthyroid animals treated with T 3 and alpha-amanitin, a delayed increase in malic enzyme activity was observed at 72 h and attained values at 96 h similar to those in euthyroid animals injected with T 3 only. (elsevier.com)
  • POLR2A encodes an enzyme that is inhibited by alpha-amanitin. (mdanderson.org)
  • As compared to NGF, cAMP produces a different pattern of enzyme induction (in addition to TH, DBH, PNMT, and AChE, dopa decarboxylase (DDC) is also induced), it acts rapidly (a 12-hr exposure produces the full effect), and it acts only at the transcriptional level (its effects are blocked by alpha-amanitin). (jneurosci.org)
Amino1
  • alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids. (wikipedia.org)
Urine1
  • Amanitin analysis in urine is a valuable diagnostic tool and does significantly contribute to the management of mushroom poisoning. (buhlmannlabs.ch)
Substances1
  • Ibotenic Acid Muscimol Other compounds: Chemically modified silibininsilibinin dihydrogen disuccinate disodium trade name Legalon SIL a solution for IV administrationis used in treatment of severe intoxications with hepatotoxic substances such as paracetamol and amanitins. (xsite.live)
Vitro1
  • Over expression of transcripts by IVM oocytes is particularly interesting, therefore, a variety of approaches were employed to determine whether the observed transcriptional changes during IVM were real or an artifact of the techniques used during analysis, including the analysis of transcript abundance in oocytes in vitro matured in the presence of α-amanitin. (springer.com)
Detection1
  • The linear range for alpha-amanitin was 3-200 ng/ml, and the relative limit of detection in plasma was 2 ng/ml at a signal-to-noise ratio of 2. (univr.it)
Cells3
  • Human hepatoma cell line HepG2 cells were pretreated in the presence or absence of GLEA (50, 100 and 200µg/ml) for 4 hours, then exposed to 60µmol/L of α-amanitin for an additional 4 hours. (bvsalud.org)
  • Our results show that alpha-amanitin blocks cells specifically in G1, irrespective of the concentration within the range of 3 to 30 micrograms/ml. (biomedsearch.com)
  • SBamr grew normally not only in cells treated with AMD but also in alpha-A-treated cells. (asm.org)
Toxic2
  • 3. Alpha-Amanitin: This is a simple, natural, toxic peptide produced by a mushroom. (personalcaretruth.com)
  • First, we found that uninfected females did not prefer to eat or lay their eggs on toxic food, indicating that selection has not acted on the flies to alter their behaviour towards α-amanitin to prevent their offspring from becoming infected by Howardula. (unboundmedicine.com)
Comparative1
  • Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. (harvard.edu)
Subunit1
  • RNA polymerase "core" from E. coli consists of five subunits: two alpha (α) subunits of 36 kDa, a beta (β) subunit of 150 kDa, a beta prime subunit (β′) of 155 kDa, and a small omega (ω) subunit. (wikipedia.org)
Effects2
  • it is not unusual for significant effects to take as long as 24 hours after ingestion to appear, with this delay in symptoms making α-amanitin poisoning even more difficult to diagnose and all the more dangerous. (wikipedia.org)
  • The aim of this study was to investigate whether Glehnia littoralis ethyl acetate extract (GLEA) has the protective antioxidant effects on α-amanitin -induced hepatotoxicity. (bvsalud.org)
Methods1
  • Early methods to detect alpha-amanitin included thin-layer chromatography (TLC). (wikipedia.org)
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