A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Glycoproteins found on the membrane or surface of cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.
Antibodies produced by a single clone of cells.
Established cell cultures that have the potential to propagate indefinitely.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
Carnivores of the genus Procyon of the family PROCYONIDAE. Two subgenera and seven species are currently recognized. They range from southern Canada to Panama and are found in several of the Caribbean Islands.
Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.
Acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf.
Live vaccines prepared from microorganisms without their virulence altered. Examples include smallpox (vaccinia) and adenovirus vaccines.
The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine.
Any of several carnivores in the family CANIDAE, that possess erect ears and long bushy tails and are smaller than WOLVES. They are classified in several genera and found on all continents except Antarctica.

Positive and negative elements modulate the promoter of the human liver-specific alpha2-HS-glycoprotein gene. (1/175)

The human alpha2-HS-glycoprotein (AHSG) and the 63-kDa rat phosphoprotein (pp63) are homologous plasma proteins that belong to the fetuin family. AHSG and pp63 are involved in important functions such as inhibition of insulin receptor tyrosine kinase activity, inhibition of protease activities, and regulation of calcium metabolism and osteogenesis. Studies of the AHSG proximal promoter performed in vitro in rat and human cells indicate that several NF-1 and C/EBP binding sites exert a positive effect on its transcriptional activity. However, until now, no distal elements have been examined in this gene, in either species. We report that the human AHSG gene promoter acts in a liver-specific manner and is further controlled by three distal, 5'-flanking elements. The negative elements III and I are, respectively, located 5' and 3' of the positive element II. All three elements require the natural context of the human AHSG gene to fully exert their negative or positive effect. Element I harbours a single binding site for NF-1. This nuclear factor thus appears to be able to up- or downregulate the AHSG gene depending on the site it binds to. Elements I, II and possibly III are absent in the rodent Ahsg gene encoding pp63.  (+info)

Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. (2/175)

A fraction of alpha2-Heremans-Schmid (alpha2-HS) glycoprotein (human fetuin) isolated from plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide fragment sequencing after tryptic digestion. Serine-312-containing peptides were phosphorylated to 77% as determined from relative peak heights in the mass spectrum, which together with the phosphorylation of serine-120 implies a molar degree of phosphorylation of at least 1. Approximately 20% of the circulating fetuin plasma pool was phosphorylated to approx. 1 mol of phosphate/mol of protein. The remainder did not contain phosphate, resulting in an average phosphorylation degree for the protein in plasma of approx. 0.2 mol/mol. The isolated alpha2-HS glycoprotein was a heterodimer in which the entire C-terminal part of the connecting peptide including threonine-321 was present, but traces of C-terminally trimmed connecting peptide fragments were also found. The short B-chain was O-glycosylated to approx. 40%, whereas the N-glycosylation of asparagine-138 and asparagine-158 seemed to be 100%. This finding, for the first time, that circulating human plasma fetuin is partly phosphorylated, implies that the effects of phosphorylated alpha2-HS glycoprotein on insulin signal transduction seen in different cell systems could be relevant to its physiological function in vivo.  (+info)

Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human alpha2-HS glycoprotein. (3/175)

Fetuin/alpha2-HS glycoprotein (alpha2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb Bgl II fragment contained exons 2, 3 and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of (T,C)n*(A,G)n. We have mapped mouse Ahsg at 16 cM adjacent to the Diacylglycerol kinase 3 (Dagk3) gene on chromosome 16 by genotyping interspecific backcross panels between C57BL/6J and Mus spretus. The position is syntenic with human chromosome 3q27, where the human AHSG gene resides. Using recombinant mouse alpha2-HSG expressed from a recombinant baculovirus, we demonstrate that mouse alpha2-HSG inhibits insulin-stimulated IR autophosphorylation and IR-TKA in vitro. In addition, mouse alpha2-HSG (25 microg/ml) completely abolishes insulin-induced DNA synthesis in H-35 rat hepatoma cells. Based on the sequence data and functional analysis, we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.  (+info)

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. (4/175)

Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein alpha2-HS-glycoprotein/fetuin (ASHG) binds to TGF-beta/BMP cytokines and blocks TGF-beta1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg(-/-) mice appeared normal at birth, but abnormalities were observed in adult Ahsg(-/-) mice. Maturation of growth plate chondrocytes was impaired, and femurs lengthened more slowly between 3 and 18 months of age in Ahsg(-/-) mice. However, bone formation was increased in Ahsg(-/-) mice as indicated by greater cortical thickness, accelerated trabecular bone remodeling, and increased osteoblast numbers on bone surfaces. The normal age-related increase in cortical thickness and bone mineral density was accelerated in Ahsg(-/-) mice and was associated with increased energy required to fracture. Bone formation in response to implanted BMP cytokine extended further from the implant in Ahsg(-/-) compared with Ahsg(+/+) mice, confirming the interaction between ASHG and TGF-beta/BMP cytokines in vivo. Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.  (+info)

Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. (5/175)

Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the metabolic syndrome. Here, we explore insulin signaling, glucose homeostasis, and the effect of a high-fat diet on weight gain, body fat composition, and glucose disposal in mice carrying two null alleles for the gene encoding fetuin, Ahsg (B6, 129-Ahsg(tm1Mbl)). Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle. Glucose and insulin tolerance tests in fetuin KO mice indicate significantly enhanced glucose clearance and insulin sensitivity. Fetuin KO mice subjected to euglycemic-hyperinsulinemic clamp show augmented sensitivity to insulin, evidenced by increased glucose infusion rate (P = 0.077) and significantly increased skeletal muscle glycogen content (P < 0.05). When fed a high-fat diet, fetuin KO mice are resistant to weight gain, demonstrate significantly decreased body fat, and remain insulin sensitive. These data suggest that fetuin may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.  (+info)

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. (6/175)

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.  (+info)

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. (7/175)

Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification. Using electron microscopy and dynamic light scattering, we demonstrate that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate. These "calciprotein particles" of 30-150 nm in diameter are initially amorphous and soluble but turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion. Solubilization in Ahsg-containing calciprotein particles provides a novel conceptual framework to explain how insoluble calcium precipitates may be transported and removed in the bodies of mammals. Mutational analysis showed that the basic calcium phosphate precipitation inhibition activity resides in the amino-terminal cystatin-like domain D1 of Ahsg. A structure-function analysis of wild type and mutant forms of cystatin-like domains from Ahsg, full-length fetuin-B, histidine-rich glycoprotein, and kininogen demonstrated that Ahsg domain D1 is most efficient in inhibiting basic calcium phosphate precipitation. The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition.  (+info)

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. (8/175)

Ectopic calcification is a frequent complication of many degenerative diseases. Here we identify the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level. Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D-rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background. This phenotype is not associated with apparent changes in calcium and phosphate homeostasis, but with a decreased inhibitory activity of the Ahsg-deficient extracellular fluid on mineral formation. The same underlying principle may contribute to many calcifying disorders including calciphylaxis, a syndrome of severe systemic calcification in patients with chronic renal failure. Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases.  (+info)

The symptoms of rabies can vary depending on the severity of the infection and the individual's overall health. Early symptoms may include fever, headache, weakness, and fatigue. As the disease progresses, symptoms can become more severe and can include:

* Agitation and confusion
* Seizures and paralysis
* Hydrophobia (fear of water)
* Spasms and twitching
* Increased salivation
* Fever and chills
* Weakness and paralysis of the face, arms, and legs

If left untreated, rabies is almost always fatal. However, prompt medical attention, including the administration of post-exposure prophylaxis (PEP), can prevent the disease from progressing and save the life of an infected person. PEP typically involves a series of injections with rabies immune globulin and a rabies vaccine.

Rabies is a significant public health concern, particularly in developing countries where access to medical care may be limited. According to the World Health Organization (WHO), there are an estimated 55,000-60,000 human deaths from rabies each year, mostly in Asia and Africa. In the United States, rabies is relatively rare, with only a few cases reported each year. However, it is still important for individuals to be aware of the risks of rabies and take precautions to prevent exposure, such as avoiding contact with wild animals and ensuring that pets are up-to-date on their vaccinations.

Vaccinia is most commonly associated with smallpox, which is caused by a similar virus and was eradicated in the late 1970s through widespread vaccination. However, there have been occasional outbreaks of vaccinia in the United States and other countries since then, often linked to laboratory accidents or deliberate releases of the virus.

The treatment of vaccinia typically involves supportive care, such as rest, hydration, and antipyretic medications to reduce fever. Antiviral medications may also be used in some cases. Prevention of the disease relies on avoiding contact with infected animals or people, and on following proper infection control practices in laboratory and healthcare settings.

Vaccinia is a serious viral infection that can have severe consequences if left untreated. It is important to seek medical attention immediately if symptoms persist or worsen over time.

Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes and adipocytes. The AHSG molecule ... 1986). "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein". J. Biol. Chem. 261 (4): 1665- ... 2001). "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene". Ann. Hum. Genet. 65 (Pt 1): 27-34. doi:10.1046/j ... 1983). "Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary ...
Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists ... "The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification". J ... Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW (1996). "Fetuin/alpha2-HS glycoprotein is a transforming growth factor ... Fetuin relatives within this superfamily are the histidine-rich glycoprotein (HRG) and kininogen (KNG). The function of Fetuin- ...
ALPHA LIPOIC ACID AS ADD-ON THERAPY TO SUBCUTANEOUS INTERFERON Β-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS: A PILOT STUDY, ... temelimab or Geneuro GNbAC1 - Monoclonal antibody against the viral The HERV-W envelope glycoprotein, which is supposed to be ... Fetuin-A (alpha-2-HS-glycoprotein) and circulating CD49 expression are emerging biomarkers for the therapeutic efficacy of ... alpha and ERbeta ligand treatment". Proceedings of the National Academy of Sciences of the United States of America. 104 (37): ...
Protein sequencing of Gigantopithecus enamel identified alpha-2-HS-glycoprotein (AHSG), which, in modern apes, is important in ... used the dimensions of gorillas to estimate a femur length of 54.4 cm (1 ft 9 in) and humerus length of 62.7 cm (2 ft 1 in) for ... 36 (2): 141-160. doi:10.30883/jba.v36i2.241. Zhang, Y.; Jin, C.; et al. (2015). "A fourth mandible and associated dental ... 54 (2): 196-204. doi:10.1016/j.jhevol.2007.09.013. PMID 18045651. Ciochon, R.; Piperno, D. R.; Thompson, R. G. (1990). "Opal ...
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... gangliosidoses Alpha-galactosidase Fabry disease (alpha-galactosidase A) Schindler disease (alpha-galactosidase B) Beta- ... Glycoprotein storage disorders (E77.0-E77.1) Mucolipidoses Also, glycogen storage disease type II (Pompe disease) is a defect ... B deficiency Multiple sulfatase deficiency Mucopolysaccharidoses Type I MPS I Hurler syndrome MPS I S Scheie syndrome MPS I H-S ... glycoproteins (sugar-containing proteins), or so-called mucopolysaccharides. Individually, lysosomal storage diseases occur ...
This enzyme is a homodimeric glycoprotein that hydrolyses the terminal α-galactosyl moieties from glycolipids and glycoproteins ... Bernstein HS, Bishop DF, Astrin KH, Kornreich R, Eng CM, Sakuraba H, Desnick RJ (April 1989). "Fabry disease: six gene ... Dean KJ, Sweeley CC (October 1979). "Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and ... alpha-Galactosidase at the US National Library of Medicine Medical Subject Headings (MeSH) Human GLA genome location and GLA ...
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Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. CD200R1 is ... Karteris E, Chen J, Randeva HS (April 2004). "Expression of human prepro-orexin and signaling characteristics of orexin ... CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), ... It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons, epithelial ...
Kooter JM, Borst P. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence ... Heymans HS, Schutgens RB, Tan R, van den Bosch H, Borst P. Severe plasmalogen deficiency in tissues of infants without ... Ouellette M, Hettema E, Wust D, Fase-Fowler F, Borst P. Direct and inverted DNA repeats associated with P-glycoprotein gene ... Boothroyd JC, Cross GA, Hoeijmakers JH, Borst P. A variant surface glycoprotein of Trypanosoma brucei synthesized with a C- ...
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Quillen EE, Haslam GC, Samra HS, Amani-Taleshi D, Knight JA, Wyatt DE, Bishop SC, Colvert KK, Richter ML, Kitos PA (July 2006 ... Eckardt K, Schober A, Platzbecker B, Mracek T, Bing C, Trayhurn P, Eckel J (May 2011). "The adipokine zinc-α2-glycoprotein ... impact of a borano group on alpha-P position". Nucleosides Nucleotides Nucleic Acids. 27 (4): 319-31. doi:10.1080/ ... 26 (2): 117-21. doi:10.1055/s-0028-1091393. PMID 18850517. Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, ...
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Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, ... Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). "Evidence of HIV type 1 glycoprotein 120 binding to ... "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a ... 92 (1-2): 54-9. doi:10.1016/j.physbeh.2007.05.026. PMID 17617428. S2CID 21646700. Kornau HC, Schenker LT, Kennedy MB, Seeburg ...
This is the case for the sugar and lipid moieties in glycoproteins and lipoproteins or RNA in ribosomes. They can be very large ... Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). "A novel coenzyme from bacterial primary alcohol dehydrogenases". Nature ... Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH (1998). "Alpha-lipoic acid in liver metabolism and disease ...
"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... The N-terminal domain of the mature protein forms an alpha-helix that constitutes the exposed part of the binding groove, the C ... 1983). "Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for ...
"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit ... The class II protein is a heterodimer consisting of an alpha (DRα) and a beta chain (DRβ), both anchored in the membrane. It ...
Fagerholm SC, Lek HS, Morrison VL (2014). "Kindlin-3 in the immune system". American Journal of Clinical and Experimental ... Kindlin 3 is a cytoskeletal signalling protein involved in the activation of the glycoprotein receptor, integrin. Together with ... Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions and ... Isoform 2 may act as a repressor of NF-kappa-B and apoptosis It has been suggested that the evolutionary source of a single ...
Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 & PLC-gamma 2 by src-family protein tyrosine ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ... Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and ... Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ...
Daugherty MD, Malik HS (August 2014). "How a virus blocks a cellular emergency access lane to the nucleus, STAT!". Cell Host & ... The genome of the Ebola virus was found to encode seven proteins: glycoprotein; nucleoprotein; matrix proteins, VP40 and VP24; ... August 2014). "Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear ... KPNA proteins have 10 armadillo repeats each consisting of three alpha helices which determine their binding specificity, the ...
Human T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB. Overview of all the structural information available in the ... Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen ... Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ...
Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. ... Serpin A12 has a single protein domain consisting of 7 to 9 alpha helices and 3 beta strands (A,B,C). Serpins are a large group ... Serpin A12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine ... The explanation for this lies in the fact that type 2 diabetes is related to inflammation processes, hence coinciding with the ...
Jiang F, Yeo CW, Lee SS, Oh MK, Ghim JL, Shon JH, Kim HS, Kim EY, Kim DH, Shin JG (2013). "Effect of HNF4α genetic polymorphism ... This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ... Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear ...
Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ (1996). "Ex-vivo expansion of murine marrow cells with IL-3, Il-6, Il-11 and ... Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid ... Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S (1995). "HIV-1 envelope glycoproteins induce ... induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but ...
Gurney ME, Heinrich SP, Lee MR, Yin HS (October 1986). "Molecular cloning and expression of neuroleukin, a neurotrophic factor ... 2009). "Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid ... and peptides from HIV-1 envelope glycoprotein". Journal of Neuroscience Research. 23 (2): 217-224. doi:10.1002/jnr.490230212. ... 1480 (1-2): 235-244. doi:10.1016/s0167-4838(00)00075-3. PMID 11004567. Sun YJ, Chou CC, Chen WS, Wu RT, Meng M, Hsiao CD (May ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB ... Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, Raff MC (1992). "Cell Death and Control of Cell Survival in ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ... "Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) ...
GAGAL promotes the alpha helicity of lacritin's C-terminal amphipathic alpha helix and likely binds to the hydrophobic face. ... "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6 ... Koo BS, Lee DY, Ha HS, Kim JC, Kim CW (2005). "Comparative analysis of the tear protein expression in blepharitis patients ... Lacritin is a glycoprotein of the human tear film, and to a lesser extent of saliva, lung lavage and plasma. It is mainly ...
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M ... The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic ... Yan R, Munzner JB, Shuck ME, Bienkowski MJ (Sep 2001). "BACE2 functions as an alternative alpha-secretase in cells". The ... Beta-secretase 2 (EC 3.4.23.45, also known as Memapsin-1) is an enzyme that cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the ...
"Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ... Padanilam BJ, Stadler HS, Mills KA, McLeod LB, Solursh M, Lee B, Ramirez F, Buetow KH, Murray JC (Sep 1992). "Characterization ... "Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter". ... TATA binding protein and Msh homeobox 2. LHX2, a LIMtype homeoprotein, is a protein partner for MSX1 in vitro and in cellular ...
Roehm PC, Shekarabi M, Wollebo HS, Bellizzi A, He L, Salkind J, Khalili K (April 2016). "Inhibition of HSV-1 Replication by ... A study from the Albert Einstein College of Medicine, where glycoprotein D (gD-2) was deleted from the herpes cell, showed ... "The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion". PLOS Pathogens. 13 ( ... Aubert M, Madden EA, Loprieno M, DeSilva Feelixge HS, Stensland L, Huang ML, Greninger AL, Roychoudhury P, Niyonzima N, Nguyen ...
Gamma-interferon produced by activated lymphocytes and macrophages plays a major role in the synthesis of 1 alpha, 25(OH)2D3. ... Porter N, Beynon HL, Randeva HS (August 2003). "Endocrine and reproductive manifestations of sarcoidosis". QJM. 96 (8): 553-61 ... glycoprotein and iron. Sarcoidosis in a lymph node Pulmonary sarcoidosis with granulomas with Langhans giant cells and asteroid ... Callejas-Rubio JL, López-Pérez L, Ortego-Centeno N (December 2008). "Tumor necrosis factor-alpha inhibitor treatment for ...
Mohapatra RK, Kandi V, Sarangi AK, Verma S, Tuli HS, Chakraborty S, et al. (July 2022). "The recently emerged BA.4 and BA.5 ... or Alpha) variant, from the previously dominant Delta variant. Thus, countries which primarily rely on SGTF for detection may ... Mohapatra RK, Kandi V, Tuli HS, Chakraborty C, Dhama K (August 2022). "The recombinant variants of SARS-CoV-2: Concerns ... Alpha, Beta, Gamma, Delta, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu Sikhulile Moyo, scientist who discovered SARS-CoV ...
Although HS chains are not required for correct folding and secretion of the protein, lack of HS or decreased sulfation can ... In a mouse model of Alzheimer's plaque formation, IL-1-alpha effects an increase in perlecan expression in response to brain ... as well as several other sulfated matrix glycoproteins. This mimics the in vivo corneal fibroblast's developmental program and ... Domain V also has attachment sites for HS/CS chains. Thus, perlecan core protein and HS chains could modulate matrix assembly, ...
Hain HS, Hakonarson H (June 2016). "The Added Value of Family Material in the Discovery of Multiple Sclerosis Genes". Neuron. ... These recent problems with artificial anti-TNF-α autoimmunity also point to the possibility of tumor necrosis factor alpha ... presentation detecting anti-myelin oligodendrocyte glycoprotein (MOG) antibody]". Rinsho Shinkeigaku = Clinical Neurology. 58 ( ... 2-072). Koutsis G, Breza M, Velonakis G, Tzartos J, Kasselimis D, Kartanou C, et al. (February 2019). "X linked Charcot-Marie- ...
Recently, direct measurement of vinblastine binding to permease-glycoprotein (P-glycoprotein) in the presence of ... Dong J, Yang G, McHaourab HS (May 2005). "Structural basis of energy transduction in the transport cycle of MsbA". Science. 308 ... The T domains are each built of typically 10 membrane spanning alpha helices, through which the transported substance can cross ... P-glycoprotein is the best-studied efflux pump and as such has offered important insights into the mechanism of bacterial pumps ...
... comparison of complementary DNA encoding Hp alpha 1S and Hp alpha 2FS". Nucleic Acids Res. 12 (11): 4531-8. doi:10.1093/nar/ ... Erickson LM, Kim HS, Maeda N (1993). "Junctions between genes in the haptoglobin gene cluster of primates". Genomics. 14 (4): ... Hemopexin (Hx) is another plasma glycoprotein that is able to bind heme with high affinity. Hemopexin sequesters heme in an ... "Characterization of human haptoglobin cDNAs coding for alpha 2FS beta and alpha 1S beta variants". FEBS Lett. 168 (1): 103-7. ...
Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, et al. (June 2010). "Hypoxic tumor cell modulates its microenvironment to ... exosomes appear to play a role in the spread of alpha-synuclein, and are being actively investigated as a tool to both monitor ... glycoproteins, DNA and mRNA. Exosome formation starts with the invagination of the multi-vesicular bodies (MVBs) or late ... 10 (2): 1802-9. doi:10.1021/acsnano.5b07584. PMC 4802494. PMID 26808216. Shao H, Chung J, Lee K, Balaj L, Min C, Carter BS, et ...
... is a SIBLING (glycoprotein) that was first identified in 1986 in osteoblasts. The prefix osteo- indicates that the ... Burdo TH, Wood MR, Fox HS (June 2007). "Osteopontin prevents monocyte recirculation and apoptosis". Journal of Leukocyte ... Chang PL, Prince CW (April 1991). "1 alpha,25-dihydroxyvitamin D3 stimulates synthesis and secretion of nonphosphorylated ... "Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha ...
Smith HS (July 2009). "Opioid metabolism". Mayo Clinic Proceedings. 84 (7): 613-624. doi:10.4065/84.7.613. PMC 2704133. PMID ... O'Brien FE, O'Connor RM, Clarke G, Dinan TG, Griffin BT, Cryan JF (October 2013). "P-glycoprotein inhibition increases the ... While trazodone (an antidepressant with alpha adrenergic receptor blockade) is a notorious cause of priapism, cases of priapism ... About 1 to 2 babies per 1000 babies born in the U.S. develop PPHN shortly after birth, and often they need intensive medical ...
... such as alpha 1-antichymotrypsin, alpha 2-antiplasmin and Heparin cofactor II. The physiological target proteases of ... Zettlmeissl G, Conradt HS, Nimtz M, Karges HE (1989). "Characterization of recombinant human antithrombin III synthesized in ... Antithrombin (AT) is a small glycoprotein that inactivates several enzymes of the coagulation system. It is a 432-amino-acid ... Turk B, Brieditis I, Bock SC, Olson ST, Björk I (1997). "The oligosaccharide side chain on Asn-135 of alpha-antithrombin, ...
Jin L, Lee EM, Ramshaw HS, Busfield SJ, Peoppl AG, Wilkinson L, Guthridge MA, Thomas D, Barry EF, Boyd A, Gearing DP, Vairo G, ... The cell surface receptor interleukin-3 receptor-alpha (CD123) is overexpressed on CD34+CD38- leukemic stem cells (LSCs) in ... CD90 (THY1) is a glycosylphosphatidylinositol glycoprotein anchored in the plasma membrane and involved in signal transduction ... is a type 1 membrane glycoprotein, which delivers an inhibitory signal to immune cells including T cells, natural killer cells ...
Haynes BF, Hemler ME, Mann DL, Eisenbarth GS, Shelhamer J, Mostowski HS, Thomas CA, Strominger JL, Fauci AS (1981). " ... a type II membrane glycoprotein involved in normal and neoplastic cell growth". Proc. Natl. Acad. Sci. U.S.A. 84 (18): 6526-30 ... transmembrane protein with an alpha-amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound ... L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". EMBO J. 18 (1 ...
Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... This protein domain is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long ... β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein ... Shi T, Giannakopoulos B, Iverson GM, Cockerill KA, Linnik MD, Krilis SA (2005). "Domain V of beta2-glycoprotein I binds factor ...
Shapiro HS, Chen J, Wrana JL, Zhang Q, Blum M, Sodek J (November 1993). "Characterization of porcine bone sialoprotein: primary ... Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone ... 280 (2): 460-5. doi:10.1006/bbrc.2000.4146. PMID 11162539. Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK, ... 43 (2): 127-35. doi:10.1111/j.1600-0765.2007.01014.x. PMID 18302613. Human IBSP genome location and IBSP gene details page in ...
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing ... HS. , Kang. HJ. , et al. Human transcriptome analysis of acute responses to glucose ingestion reveals the role of leukocytes in ... Table 2. Differentially expressed genes in PLNs of 16-week-old NOD mice expressing high levels of Deaf1-Var1 versus those ... 2 and Supplementary Fig. 2). This suggested that both hyperglycemia and/or inflammation may play roles in Deaf1 splicing. We ...
... inhibin alpha, and interleukin 6). Also, CD4 antigen, IL-4 and IL-10 mRNA decreased in young 3 week HRLF rats, but not in aged ... while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. Clear trends of ... Advanced Search Search Help About NIOSHTIC-2 Feedback Terms: ergonom* or musculoskeletal or repetitive or carpal OR ergonom ... Six of each age group performed a high repetition low force (HRLF) task for 2 hrs/dy, 3 dys/wk for 3 weeks. The remaining were ...
2 型糖尿病患者を対象とした服薬アドヒアランス〜良好な血糖管理に必要な服薬遵守度・遵守率の検討〜. Translated title of the contribution. : Medication adherence in patients with ... Urinary angiotensinogen is a marker for tubular injuries in patients with type 2 diabetes. Terami, T., Wada, J., Inoue, K., ... Serum galectin-9 levels are elevated in the patients with type 2 diabetes and chronic kidney disease. Kurose, Y., Wada, J., ... Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes
HS Glycoprotein. alpha-2HS Glycoprotein. alpha2 Heremans-Schmid Glycoprotein. alpha2HS Glycoprotein. Tree number(s):. D12.776. ... HS Glycoprotein alpha-2HS Glycoprotein alpha2 Heremans-Schmid Glycoprotein alpha2HS Glycoprotein ... alpha-2-HS-Glycoprotein - Preferred Concept UI. M0555326. Scope note. A fetuin subtype that is synthesized by HEPATOCYTES and ... alpha-2-HS-Glycoprotein Entry term(s). AHSG Protein Fetuin A Fetuin-A alpha 2 HS Glycoprotein alpha 2HS Glycoprotein alpha(2) ...
... prothymosin alpha and alpha-fetoprotein were found to be down-regulated by THs.Transferrin, an iron-binding protein expressed ... Our results indicate that several plasma proteins including transferrin, prothrombin, angiotensinogen, haptoglobin, alpha-2-HS- ... glycoprotein alpha and beta chain, complement, lipoproteins and fibrinogen are up-regulated by THs. Furthermore, clusterin, ... You are looking at 1 - 2 of 2 items for * Author: CC Lee x ...
Among them, alpha-2-HS-glycoprotein demonstrated a strong negative correlation with age. These results suggest that analysis of ... 2. Corrigendum: Comparison of Periodontal Bacteria of Edo and Modern Periods Using Novel Diagnostic Approach for Periodontitis ...
The proteomics and genomics discovery phases yielded an increase in RANTES (CCL5), CXCL2 (GRO2), and Leucine Rich Alpha-2- ... glycoprotein in non-healing patients whereas there was an increase in interleukin IL-8, granulocyte colony stimulating factor ( ... Alpha-2-HS-glycoprotein, and Kininogen 1 in healing patients. We are currently validating these results in archived patient ... 2021;29(2):115-121. doi: 10.3233/HAB-210439.. Background: The diagnosis of osteomyelitis is a key step of diabetic foot ...
This targeted PRM analysis confirmed that alpha-2-HS-glycoprotein was upregulated in the stressed group after one and three ... Within 2 months, a fourth follow-up MRI showed that the lesion had spread to the left parietal cortex, subcortical white matter ... Results Of 86 isolates, 39 (45.3%) were of Delhi/CAS genotype, 24 (27.9%) of NEW-1, 6 (7%) of LAM, 6 (7%) of Beijing, 2 (2.3%) ... Of 2400 blood samples, there were 2(0.08%) HBsAg positive samples, 3(0.13%) anti-HCV positive samples, 29(1.21%) IgM anti-HEV ...
P-glycoprotein): Possible use in cancer chemotherapy. Cancer Lett 248: 147-152.. CHANG H-S, YAMATO O, YAMASAKI M, KO M, MAEDE Y ... Linn) on the damages induced by nicotine in rats as compared to alpha-tocopherol. Toxicol Lett 116: 61-68. HOLLMAN PC, VAN- ... RUEFLI AA, JOHNSTONE RW (2003) A role for P-glycoprotein in regulating cell growth and survival. Clin Appl Immunol Rev 4: 31-47 ... Ana P. S. Votto1,2, Beatriz S. Domingues1,2, Michele M. de Souza3, Flavio M. R. da Silva Júnior2, Sergiane S. Caldas4, Daza M. ...
In: Brown F, Chanock RM, Ginsberg HS, Lerner RA, eds. Vaccines 90: modern approaches to new vaccines including prevention of ... HIV exhibits considerable genetic variability, particularly in the gene for its envelope glycoprotein (gp120), and analyses of ... and D encoding the human leukocyte antigen DQ alpha were amplified by the polymerase chain reaction. The lengths of the ... 2. Ou CY, Kwok S, Mitchell SW, et al. DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear ...
Brabers NA, Nottet HS. Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia. Eur J Clin ... 15] Autoantibodies against myelin oligodendrocyte glycoprotein may persist in a high percentage of patients despite viral ... Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study. ... Future trials might include monoclonal antibodies against interleukins 1 and 6 and tumor necrosis factor-alpha. ...
Anti-PR3 hs. Rheumatology Diagnostics. ANA Detect. ANAcombi. ANAscreen. Anti-Alpha Fodrin IgGA. Anti-C1q. Anti-CCPhs. Anti- ... ANCAscreen hs. Anti BPI. Anti-Cathepsin G. Antia-Elaste. Anti-GBM. Anti-Lactoferrin. Anti-Lysozyme. Anti-MPO. Anti-PR3. ... Anti-beta-2-Glycoprotein. Anti-Cardiolipin IgA. Anti-Cardiolipin IgGM. Anti-Cardiolipin Screen. Anti-Phosphatidic Acid IgG. ...
... d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan), is a polymeric, synthetic version of vitamin E. Tocoph ... Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger ... The role of p-glycoprotein and related drug efflux systems in limiting oral drug absorption. Adv Drug Deliv Rev 1997; 25(2): ... Mechanistic study of solubility enhancement of nifedipine using vitamin E TPGS or solutol HS-15. Drug Deliv 2006; 13(3): 201-6. ...
In: Brown F, Chanock RM, Ginsberg HS, Lerner RA, eds. Vaccines 90: modern approaches to new vaccines including prevention of ... HIV exhibits considerable genetic variability, particularly in the gene for its envelope glycoprotein (gp120), and analyses of ... and D encoding the human leukocyte antigen DQ alpha were amplified by the polymerase chain reaction. The lengths of the ... MMWR 40(2);21-27,33 Publication date: 01/18/1991. Table of Contents. Article. Editorial Note. References. POINT OF CONTACT FOR ...
Glycoproteins [D12.776.395] * Activins [D12.776.395.022] * ADAM Proteins [D12.776.395.033] * alpha 1-Antichymotrypsin [D12.776. ... Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form ... Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form ... Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the ...
Tarassishin, L., Suh, H.-S., and Lee, S. C. (2011). Interferon regulatory factor 3 plays an anti-inflammatory role in microglia ... Although the host innate immune response including TLR, type 1 interferon, TNF alpha, and IL-6 are the first defense line ... Lay, S., Préhaud, C., Dietzschold, B., and Lafon, M. (2003). Glycoprotein of nonpathogenic rabies viruses is a major inducer of ... Préhaud, C., Lay, S., Dietzschold, B., and Lafon, M. (2003). Glycoprotein of nonpathogenic rabies viruses is a key determinant ...
AP71439 Recombinant human Alpha/beta hydrolase domain-containing protein 14B 11055 6930 4125 2508 1452 0 1012 E.coli HUMAN His- ... AP71192 Recombinant Rabies virus Glycoprotein G 16280 10230 7678 4664 2706 0 1903 E.coli RABVE His-SUMO-tag Store at -20°C, for ... AP71204 Recombinant Escherichia coli O9:H4 (strain HS) Outer-membrane lipoprotein carrier protein 16280 10230 7678 4664 2706 0 ... AP71393 Recombinant mouse Alpha/beta hydrolase domain-containing protein 11 16280 10230 6094 3707 2145 0 1507 E.coli MOUSE His- ...
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin ... Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin Kisiel, W ... fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens) * Extracellular thrombin inactivating ... factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides (Homo sapiens) * Extracellular thrombin ...
Structures of glycoprotein Ib alpha and its complex with von Willebrand factor A1 domain. Science. 2002;297(5584):1176-9. ... Markus HS, McCollum C, Imray C, Goulder MA, Gilbert J, King A. The von Willebrand inhibitor ARC1779 reduces cerebral ... Fontayne A, Meiring M, Lamprecht S, Roodt J, Demarsin E, Barbeaux P, Deckmyn H. The humanized anti-glycoprotein Ib monoclonal ... Wu D, Meiring M, Kotze HF, Deckmyn H, Cauwenberghs N. Inhibition of platelet glycoprotein Ib, glycoprortein IIb/IIIa, or both ...
Hien TT, Kim ND, Kim HS, Kang KW. Ginsenoside Rg3 inhibits tumor necrosis factor-alpha-induced expression of cell adhesion ... Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. J Clin ... Kim HS, Kim DH, Kim BK, Yoon SK, Kim MH, Lee JY, Kim HO, Park YM. Effects of topically applied Korean red ginseng and its ... Lim YJ, Na HS, Yun YS, Choi IS, Oh JS, Rhee JH, Cho BH, Lee HC. Suppressive effects of ginsan on the development of allergic ...
Investigations showed that the level of CCR4 could be induced by TNF-alpha dependent of NF-kappaB activation in CRC cells. CCR4 ... A high amino acid charge of the envelope glycoprotein 120 V3 region is important for binding to host CXCR4 receptor. PMID: ... aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult T-cell ... airway allergen-specific T(H)2 cells are CCR4(+), but in the atopic child CCR4 does not distinguish between recall antigen and ...
Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, ... Pham DL, Lim KM, Joo KM, Park HS, Leung DYM, Ye YM. Increased cis-to-trans urocanic acid ratio in the skin of chronic ... anti-β2-glycoprotein 1, antimyeloperoxidase, anti-proteinase 3, anti-smooth muscle, and antinuclear antibodies, between the two ... Marla N Diakow, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American ...
... platelet membrane receptors to enhance alpha-granule and dense-granule secretion. The alpha granules store platelet activation ... Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, et al. Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose ... Aggregation occurs as TXA2 diffuses from the platelet and binds to glycoprotein IIb-IIIa (GPIIb-IIIa) ... However, the formation of 9-alpha,11-beta-prostaglandin F (PGF) metabolites by preferential conversion of PGD2 results in the ...
Oehlke, J; Scheller, A; Wiesner, B; Krause, E; Beyermann, M; Klauschenz, E; Melzig, M; Bienert, M. Cellular uptake of an alpha- ... Soundara Manickam, D; Bisht, HS; Wan, L; Mao, G; Oupický, D. Influence of TAT-peptide polymerization on properties and ... It is long known, that a peptide derived from rabies virus glycoprotein (RVG) interacts specifically with the nicotinic ... Mor, A; Nicolas, P. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol ...
Human alpha-fetoprotein (HAFP) is a single-chain glycoprotein with a molecular mass of 69 kDa or greater depending on ... Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM. ... Alpha-fetoprotein and estrogen metabolism. Influence of alpha-fetoprotein on the metabolism of steroids by rat liver microsomes ... Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity ...
... alpha(1)-acid-glycoprotein and alpha(1)-antichymotrypsin] increased 3-fold in patients with both CVD and periodontal disease [ ... Kho HS et al. Oral manifestations and salivary flow rate, pH, and buffer capacity in patients with end-stage renal disease ... Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels ... Atherosclerosis, 1996, 121(2):185-91.. *Mattila K et al. Effect of treating periodontitis on C-reactive protein levels: a pilot ...
Here, using differentiated Caco-2 cells with the established 0[I] blood group phenotype (n... , Find, read and cite all the ... 2006). The molecular basis for gal alpha (1,3) gal expression in animals with a deletion of the alpha 1,3 galactosyltransferase ... Kweon HS, Beznoussenko GV, Micaroni M, Polishchuk RS, Trucco A, Martella O, Di Giandomenico D, Marra P, Fusella A, Di Pentima A ... cross-reacting with the α-D-galactose on the B glycoprotein (van Oss, 2004). (2) These antibodies could be caused by viral ...
IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. ... Mills MN, Figura NB, Arrington JA, Yu HM, Etame AB, Vogelbaum MA, Soliman H, Czerniecki BJ, Forsyth PA, Han HS, Ahmed KA. ... Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin. Am J Pathol. 2010 Apr.176(4):2039-2050. ... Han HS, Ahmed KA. The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential ...
  • HN - 2012 MH - alpha-2-HS-Glycoprotein UI - D060749 MN - D12.776.124.790.106.304.500 MN - D12.776.157.125.283.500 MN - D12.776.215.625.500 MN - D12.776.377.715.85.304.500 MN - D12.776.395.86 MS - A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. (nih.gov)
  • The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. (nih.gov)
  • Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. (cusabio.com)
  • The 2740 m/z peak was identified as the B-chain of alpha 2-HS glycoprotein, a serum protein previously found to vary with diet and be involved in insulin resistance and immune function. (nih.gov)
  • 2. Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma. (nih.gov)
  • Furthermore, clusterin, alpha-2-macroglobulin precursor, prothymosin alpha and alpha-fetoprotein were found to be down-regulated by THs.Transferrin, an iron-binding protein expressed in all mammals, and mainly synthesized in the liver, was investigated further. (bioscientifica.com)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • 5. Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma. (nih.gov)
  • Our results indicate that several plasma proteins including transferrin, prothrombin, angiotensinogen, haptoglobin, alpha-2-HS-glycoprotein alpha and beta chain, complement, lipoproteins and fibrinogen are up-regulated by THs. (bioscientifica.com)
  • They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)
  • HN - 2012(1981) BX - alpha2 Heremans-Schmid Glycoprotein MH - Alternariosis UI - D060487 MN - C1.703.513.124 MS - Opportunistic fungal infection by a member of ALTERNARIA genus. (nih.gov)
  • it encodes a membrane-spanning glycoprotein some 1,480 amino-acid residues in length. (rtmagazine.com)
  • and 3) task performance in aged rats only (corticotropin releasing hormone, interleukin 4, interferon regulatory factor 1, inhibin alpha, and interleukin 6). (cdc.gov)
  • The proteomics and genomics discovery phases yielded an increase in RANTES (CCL5), CXCL2 (GRO2), and Leucine Rich Alpha-2- glycoprotein in non-healing patients whereas there was an increase in interleukin IL-8, granulocyte colony stimulating factor (G-CSF), colony stimulating factor-2, matrix metalloprotease 7, Alpha-2-HS-glycoprotein, and Kininogen 1 in healing patients. (podiatryarena.com)
  • We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). (cusabio.com)
  • Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). (cusabio.com)
  • BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. (cusabio.com)
  • Fetuin-A (also known as alpha 2-HS-glycoprotein), secreted by the liver into circulation, interacts with the insulin receptor, and is a physiological inhibitor of insulin receptor tyrosine kinase activity in vitro, in intact cells and in vivo in animals. (auburn.edu)
  • Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. (cusabio.com)
  • May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. (cusabio.com)
  • 8. Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas. (nih.gov)
  • 11. Serum alpha 2-HS glycoprotein predicts survival in patients with glioblastoma. (nih.gov)
  • 14. The Evaluation of AREG, MMP-2, CHI3L1, GFAP, and OPN Serum Combined Value in Astrocytic Glioma Patients' Diagnosis and Prognosis. (nih.gov)
  • Background: This study involves the investigation of spontaneous and induced secretion of the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) and the anti-inflammatory chemokine C-C motif chemokine ligand 18 (CCL18) by monocytes isolated from blood of patients with long-term type 2 diabetes mellitus (T2DM), both with or without foot ulcers. (podiatryarena.com)
  • [ 2 ] As part of the acute HIV syndrome during seroconversion, patients may experience HIV encephalopathy. (medscape.com)
  • J Radioanal Nucl Chem 170(2):333-346. (cdc.gov)
  • Tyrosine aminotransferase (EC 2.6.1.5) which catalyzes the first step in tyrosine catabolism by reversibly transferring its amino group to 2- oxoglutarate to form 4-hydroxyphenylpyruvate and L-glutamate. (nih.gov)
  • Of the approximate 30 million Americans that suffer from Type 2 diabetes, 25% will develop a foot ulcer during their lifetime that often exhibit impaired healing with a cost of diagnosis and treatment exceeding $250 billion per year. (podiatryarena.com)
  • A significant upregulation of Osteoactivin, a gene related to bone mineralization, was found in aged rats (both control and task), while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. (cdc.gov)
  • As well, sodiumon-propyl thiosulfate (NPTS), an alk(en)yl thiosulfate present in Allium cepa, suppressed the growth of HL-60 cells through the induction of apoptosis initiated by oxidative stress, indicating that the alk(en)yl thiosulfates account partly for the anti-carcinogenic properties of onion and have the potential to prevent tumors (Chang et al. (scielo.cl)
  • Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. (cusabio.com)
  • 1,2 The dominant nent of innate immunity against virally infected and signal received by an NK cell through its interaction tumor cells. (nih.gov)
  • Here, using differentiated Caco-2 cells with the established 0[I] blood group phenotype (no expression of the blood antigens A and B [AgA, AgB] under normal conditions) as a model of human enterocytes we examined whether the overloading of these cells with lipids could cause errors in the Golgi-dependent glycosylation. (techscience.com)
  • Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. (cusabio.com)
  • On the basis of sequence similarity, these various enzymes can be grouped [1,2] into subfamilies. (nih.gov)
  • It is defined as an acquired impairment in cognitive functioning involving at least 2 ability domains with a decline of daily functioning in severe cases. (medscape.com)
  • The multiple inherent properties of Tocophersolan allow it to play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability to promote drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor, and anticancer compound. (benthamscience.com)
  • A unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan), is a polymeric, synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. (benthamscience.com)
  • Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)
  • AAT catalyzes the reversible transfer of the amino group from L-aspartate to 2-oxoglutarate to form oxaloacetate and L-glutamate. (nih.gov)
  • By 1964, after recognition of this basic structure, Bergstrom and colleagues successfully synthesized series 2 prostaglandins from arachidonic acid using sheep seminal fluid. (medscape.com)
  • Evidence suggests that COX-1 and COX-2 are similar in structure and function but that they exist as 2 distinct enzymatic entities. (medscape.com)
  • The structure of alpha-fetoprotein (AFP) is presented in light of AFP membership and position in the albuminoid gene family in comparison to other gene family members. (atlasgeneticsoncology.org)
  • Six of each age group performed a high repetition low force (HRLF) task for 2 hrs/dy, 3 dys/wk for 3 weeks. (cdc.gov)
  • Cet article examine les connaissances actuelles sur la charge des maladies bucco-dentaires et systémiques et leur association, et met en lumière le manque d'information et de recherche dans la Région de la Méditerranée orientale et les autres pays en développement. (who.int)
  • The inheritance pattern was described in 1946 by Andersen and Hodges, 2 and the sweat test, which is still the most widely used means of diagnosing CF, was developed in the 1950s. (rtmagazine.com)