alpha-2-HS-Glycoprotein: A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Latex: A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.beta 2-Glycoprotein I: A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Platelet Glycoprotein GPIb-IX Complex: Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.OrosomucoidMembrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Myelin-Associated Glycoprotein: A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Platelet Glycoprotein GPIIb-IIIa Complex: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.

Positive and negative elements modulate the promoter of the human liver-specific alpha2-HS-glycoprotein gene. (1/175)

The human alpha2-HS-glycoprotein (AHSG) and the 63-kDa rat phosphoprotein (pp63) are homologous plasma proteins that belong to the fetuin family. AHSG and pp63 are involved in important functions such as inhibition of insulin receptor tyrosine kinase activity, inhibition of protease activities, and regulation of calcium metabolism and osteogenesis. Studies of the AHSG proximal promoter performed in vitro in rat and human cells indicate that several NF-1 and C/EBP binding sites exert a positive effect on its transcriptional activity. However, until now, no distal elements have been examined in this gene, in either species. We report that the human AHSG gene promoter acts in a liver-specific manner and is further controlled by three distal, 5'-flanking elements. The negative elements III and I are, respectively, located 5' and 3' of the positive element II. All three elements require the natural context of the human AHSG gene to fully exert their negative or positive effect. Element I harbours a single binding site for NF-1. This nuclear factor thus appears to be able to up- or downregulate the AHSG gene depending on the site it binds to. Elements I, II and possibly III are absent in the rodent Ahsg gene encoding pp63.  (+info)

Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. (2/175)

A fraction of alpha2-Heremans-Schmid (alpha2-HS) glycoprotein (human fetuin) isolated from plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide fragment sequencing after tryptic digestion. Serine-312-containing peptides were phosphorylated to 77% as determined from relative peak heights in the mass spectrum, which together with the phosphorylation of serine-120 implies a molar degree of phosphorylation of at least 1. Approximately 20% of the circulating fetuin plasma pool was phosphorylated to approx. 1 mol of phosphate/mol of protein. The remainder did not contain phosphate, resulting in an average phosphorylation degree for the protein in plasma of approx. 0.2 mol/mol. The isolated alpha2-HS glycoprotein was a heterodimer in which the entire C-terminal part of the connecting peptide including threonine-321 was present, but traces of C-terminally trimmed connecting peptide fragments were also found. The short B-chain was O-glycosylated to approx. 40%, whereas the N-glycosylation of asparagine-138 and asparagine-158 seemed to be 100%. This finding, for the first time, that circulating human plasma fetuin is partly phosphorylated, implies that the effects of phosphorylated alpha2-HS glycoprotein on insulin signal transduction seen in different cell systems could be relevant to its physiological function in vivo.  (+info)

Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human alpha2-HS glycoprotein. (3/175)

Fetuin/alpha2-HS glycoprotein (alpha2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb Bgl II fragment contained exons 2, 3 and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of (T,C)n*(A,G)n. We have mapped mouse Ahsg at 16 cM adjacent to the Diacylglycerol kinase 3 (Dagk3) gene on chromosome 16 by genotyping interspecific backcross panels between C57BL/6J and Mus spretus. The position is syntenic with human chromosome 3q27, where the human AHSG gene resides. Using recombinant mouse alpha2-HSG expressed from a recombinant baculovirus, we demonstrate that mouse alpha2-HSG inhibits insulin-stimulated IR autophosphorylation and IR-TKA in vitro. In addition, mouse alpha2-HSG (25 microg/ml) completely abolishes insulin-induced DNA synthesis in H-35 rat hepatoma cells. Based on the sequence data and functional analysis, we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.  (+info)

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. (4/175)

Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein alpha2-HS-glycoprotein/fetuin (ASHG) binds to TGF-beta/BMP cytokines and blocks TGF-beta1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg(-/-) mice appeared normal at birth, but abnormalities were observed in adult Ahsg(-/-) mice. Maturation of growth plate chondrocytes was impaired, and femurs lengthened more slowly between 3 and 18 months of age in Ahsg(-/-) mice. However, bone formation was increased in Ahsg(-/-) mice as indicated by greater cortical thickness, accelerated trabecular bone remodeling, and increased osteoblast numbers on bone surfaces. The normal age-related increase in cortical thickness and bone mineral density was accelerated in Ahsg(-/-) mice and was associated with increased energy required to fracture. Bone formation in response to implanted BMP cytokine extended further from the implant in Ahsg(-/-) compared with Ahsg(+/+) mice, confirming the interaction between ASHG and TGF-beta/BMP cytokines in vivo. Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.  (+info)

Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. (5/175)

Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the metabolic syndrome. Here, we explore insulin signaling, glucose homeostasis, and the effect of a high-fat diet on weight gain, body fat composition, and glucose disposal in mice carrying two null alleles for the gene encoding fetuin, Ahsg (B6, 129-Ahsg(tm1Mbl)). Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle. Glucose and insulin tolerance tests in fetuin KO mice indicate significantly enhanced glucose clearance and insulin sensitivity. Fetuin KO mice subjected to euglycemic-hyperinsulinemic clamp show augmented sensitivity to insulin, evidenced by increased glucose infusion rate (P = 0.077) and significantly increased skeletal muscle glycogen content (P < 0.05). When fed a high-fat diet, fetuin KO mice are resistant to weight gain, demonstrate significantly decreased body fat, and remain insulin sensitive. These data suggest that fetuin may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.  (+info)

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. (6/175)

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.  (+info)

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. (7/175)

Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification. Using electron microscopy and dynamic light scattering, we demonstrate that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate. These "calciprotein particles" of 30-150 nm in diameter are initially amorphous and soluble but turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion. Solubilization in Ahsg-containing calciprotein particles provides a novel conceptual framework to explain how insoluble calcium precipitates may be transported and removed in the bodies of mammals. Mutational analysis showed that the basic calcium phosphate precipitation inhibition activity resides in the amino-terminal cystatin-like domain D1 of Ahsg. A structure-function analysis of wild type and mutant forms of cystatin-like domains from Ahsg, full-length fetuin-B, histidine-rich glycoprotein, and kininogen demonstrated that Ahsg domain D1 is most efficient in inhibiting basic calcium phosphate precipitation. The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition.  (+info)

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. (8/175)

Ectopic calcification is a frequent complication of many degenerative diseases. Here we identify the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level. Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D-rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background. This phenotype is not associated with apparent changes in calcium and phosphate homeostasis, but with a decreased inhibitory activity of the Ahsg-deficient extracellular fluid on mineral formation. The same underlying principle may contribute to many calcifying disorders including calciphylaxis, a syndrome of severe systemic calcification in patients with chronic renal failure. Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases.  (+info)

*Alpha-2-HS-glycoprotein

Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two ... 1986). "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein". J. Biol. Chem. 261 (4): 1665- ... 2001). "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene". Ann. Hum. Genet. 65 (Pt 1): 27-34. doi:10.1046/j ... 1983). "Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary ...

*Fetuin

Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists ... "The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification". J ... Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW (1996). "Fetuin/alpha2-HS glycoprotein is a transforming growth factor ... Fetuin relatives within this superfamily are the histidine-rich glycoprotein (HRG) and kininogen (KNG). The function of Fetuin- ...

*ORM1

1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and ... "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". ... Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key acute phase plasma ... 1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for ...

*Multiple sclerosis drug pipeline

ALPHA LIPOIC ACID AS ADD-ON THERAPY TO SUBCUTANEOUS INTERFERON Β-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS: A PILOT STUDY, ... Fetuin-A (alpha-2-HS-glycoprotein) and circulating CD49 expression are emerging biomarkers for the therapeutic efficacy of ... alpha} and ER{beta} ligand treatment". Proceedings of the National Academy of Sciences. 104 (37): 14813-8. doi:10.1073/pnas. ... 286 (1-2): 99-103. doi:10.1016/j.jns.2009.05.028. Voskuhl, Rhonda R; Wang, HeJing; Wu, T C Jackson; Sicotte, Nancy L; Nakamura ...

*Fetuin-B

2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone ... Fetuin-A (alpha-2-HS-glycoprotein) GRCh38: Ensembl release 89: ENSG00000090512 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315 ... 2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured ...

*CITED2

"MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). " ... "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (Feb 2007). "CITED2 is expressed in human ...

*FSHB

All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the ... Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin ... The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, ... 1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry. ...

*Alpha-1-B glycoprotein

"A1BG alpha-1-B glycoprotein". Retrieved 5/10/13. Check date values in: ,access-date= (help) "EST Profile - Hs.529161". UniGene ... Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains. The alpha-1-glycoprotein is ... No paralogs have been found for alpha-1B glycoprotein. An initial NCBI Blast alignment of alpha-1B glycoprotein illustrates ... alpha-1B-glycoprotein-like". Retrieved 5/11/13. Check date values in: ,access-date= (help) "PREDICTED: alpha-1B-glycoprotein- ...

*Alpha-galactosidase

Bishop DF, Calhoun DH, Bernstein HS, Hantzopoulos P, Quinn M, Desnick RJ (1986). "Human alpha-galactosidase A: nucleotide ... enzyme is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins ... Alpha-galactosidase is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and ... glycoproteins. It is encoded by the GLA gene. Two recombinant forms of alpha-galactosidase are called agalsidase alpha (INN) ...

*Lysosomal storage disease

... gangliosidoses Alpha-galactosidase Fabry disease (alpha-galactosidase A) Schindler disease (alpha-galactosidase B) Beta- ... glycoprotein storage disorders (E77.0-E77.1) mucolipidoses Also, glycogen storage disease type II (Pompe disease) is also a ... B deficiency Multiple sulfatase deficiency Mucopolysaccharidoses Type I MPS I Hurler syndrome MPS I S Scheie syndrome MPS I H-S ... glycoproteins (sugar-containing proteins), or so-called mucopolysaccharides. Individually, LSDs occur with incidences of less ...

*PLCB3

This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. PLCB3 has been ... Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). "Regulation of phospholipase C-beta 3 activity by Na+/ ... Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ...

*HLA-DPB1

de Koster HS, Kenter MJ, D'Amaro J, et al. (1991). "Positive correlation between oligonucleotide typing and T-cell recognition ... This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It ... analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein ... 1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta ...

*GRIN3A

Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, ... Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). "Evidence of HIV type 1 glycoprotein 120 binding to ... "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a ... 706 (2): 303-7. doi:10.1016/0006-8993(95)01197-8. PMID 8822372. Dreyer EB, Lipton SA (1996). "The coat protein gp120 of HIV-1 ...

*Laminin, gamma 1

2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... Smyth N, Vatansever HS, Murray P, et al. (1999). "Absence of basement membranes after targeting the LAMC1 gene results in ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ... Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are ...

*Piet Borst

Kooter JM, Borst P. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence ... Heymans HS, Schutgens RB, Tan R, van den Bosch H, Borst P. Severe plasmalogen deficiency in tissues of infants without ... Ouellette M, Hettema E, Wust D, Fase-Fowler F, Borst P. Direct and inverted DNA repeats associated with P-glycoprotein gene ... Boothroyd JC, Cross GA, Hoeijmakers JH, Borst P. A variant surface glycoprotein of Trypanosoma brucei synthesized with a C- ...

*Integrin-linked kinase

Fukuda K, Gupta S, Chen K, Wu C, Qin J (December 2009). "The pseudoactive site of ILK is essential for its binding to alpha- ... Barry FA, Gibbins JM (April 2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The ... Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T ... 433 (2): 113-7. doi:10.1007/s004280050225. PMID 9737788. Tu Y, Li F, Goicoechea S, Wu C (March 1999). "The LIM-only protein ...

*HLA-DR

"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... The N-terminal domain of the mature protein forms an alpha-helix that constitutes the exposed part of the binding groove, the C ... 1983). "Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for ...

*HLA-DRA

"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit ... The class II protein is a heterodimer consisting of an alpha (DRα) and a beta chain (DRβ), both anchored in the membrane. It ...

*PLCG2

Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ... Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and ... Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ...

*Iduronidase

Scott, HS; Nelson, PV; Litjens, T; Hopwood, JJ; Morris, CP (September 1993). "Multiple polymorphisms within the alpha-L- ... This enzyme catalyses the hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate. It is a glycoprotein ... The defective alpha-L-iduronidase results in an accumulation of heparan and dermatan sulfate within phagocytes, endothelium, ... The enzyme acts by hydrolyzing the terminal alpha-L-induronic acid residues of these molecules, degrading them. The protein is ...

*Hepatocyte nuclear factor 4 alpha

Jiang F, Yeo CW, Lee SS, Oh MK, Ghim JL, Shon JH, Kim HS, Kim EY, Kim DH, Shin JG (2013). "Effect of HNF4α genetic polymorphism ... This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ... Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear ...

*Apolipoprotein H

Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... This protein domain is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long ... Shi T, Giannakopoulos B, Iverson GM, Cockerill KA, Linnik MD, Krilis SA (2005). "Domain V of beta2-glycoprotein I binds factor ... Apolipoprotein H (Apo-H), previously known as β2-glycoprotein I and beta-2 glycoprotein I, is a 38 kDa multifunctional ...

*CD8A

Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen ... The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ...

*Bone sialoprotein

Shapiro HS, Chen J, Wrana JL, Zhang Q, Blum M, Sodek J (November 1993). "Characterization of porcine bone sialoprotein: primary ... Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone ... 280 (2): 460-5. doi:10.1006/bbrc.2000.4146. PMID 11162539. Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK, ... 43 (2): 127-35. doi:10.1111/j.1600-0765.2007.01014.x. PMID 18302613. Human IBSP genome location and IBSP gene details page in ...

*Afamin

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6 ... Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in ... Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug ... Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L (1995). "Identification of rat alpha-albumin and cDNA cloning of its ...

*Platelet-derived growth factor

Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs. The alpha type binds to PDGF-AA, PDGF-BB and PDGF-AB ... Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, Raff MC (1992). "Cell Death and Control of Cell Survival in ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ... "Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) ...
n this study, levels of plasma α2-Heremans-Schmid glycoprotein, serum tumor necrosis factor-α, serum liver function parameters and short-term mortality were measured in 100 hepatitis B patients. Release of interleukin-6 and tumor necrosis factor-α from the lipopolysaccharide-stimulated peripheral blood mononuclear cells in the presence/absence of spermine and α2-Heremans-Schmid glycoprotein were analyzed by enzyme-linked immunosorbent assay to determine the significance and potential mechanism of α2-Heremans-Schmid glycoprotein in hepatitis B virus-associated liver damage. Results showed that serum α2-Heremans-Schmid glycoprotein levels in acute-on-chronic liver failure patients were significantly lower than that in chronic hepatitis B patients or healthy controls (p | 0.05). A negative dependence between serum human α2-Heremans-Schmid glycoprotein and tumor necrosis factor-α levels was observed. Interleukin-6 and tumor necrosis factor-α levels in the lipopolysaccharide-induced peripheral blood
The association between the development of diabetic foot and serum fetuin-A levels. Ozenç S, Simsek K, Yildirim A, Arslan E, Sari S, Ince M, Sarı O, Yeşilkaya S, Aydoğan U, Yaman H, Koç B, Sağlam K. Pol Arch Med Wewn. […]
alpha-2-HS-glycoprotein (AHSG) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in fetal than adult blood. Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. The choroid plexus is an established extrahepatic expression site. The mature circulating AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a ...
Objectives: The contribution of vascular disease to neurocognitive decline is now widely recognized. Fetuin-A is an abundant plasma protein known to predict vascular disease. Prior studies have shown that fetuin-A levels are lower in patients with Alzheimers disease in direct proportion to the severity of cognitive impairment; however, their association with normal cognitive aging is unknown. We evaluated the association of serum fetuin-A levels with cognitive function in relatively high-functioning, community-dwelling older adults from the Rancho Bernardo Study.. Methods: This is a population-based study of 1382 older adults (median age 75) who had plasma fetuin-A levels and cognitive function evaluated in 1992-96; 855 had repeat cognitive function assessment a median of 4 years later.. Results: Adjusting for age, sex, education, and depression, higher levels of fetuin-A were associated with better baseline performance on the Mini-Mental Status Exam (MMSE) (P=0.012) and a tendency for better ...
Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high incidence of vascular morbidity and mortality in this population. A network of inhibitors work in concert to reduce mineralization risk in extra-osseous tissue. Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts with mineral ions to form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought to assess whether CPP fetuin-A levels were associated with procalcific factors and aortic stiffness in a cohort of patients with Stages 3 and 4 CKD.. ...
Context: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown. Objective: To determine the association of fetuin-A levels with changes in body composition over 5 yr. Study Design: Observational cohort study nested in the Health Aging and Body Composition Study.
Nimptsch K., Aleksandrova K., Boeing H., Janke J., Lee Y-A., Jenab M., Bueno-De-Mesquita B., Tsilidis KK., Vainio EW., Jansen EHJM., Key TJ., Trichopoulou A., Overvad K., Riboli E., Pischon T., Canc EPI ...
A total of 32 studies including 27 case-control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges g = 1.73, 95% CI (1.25-2.22), P , 0.001], with significant heterogeneity across studies (P , 0.001, I 2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26-2.08), P , 0.001], with no significant heterogeneity (P = 0.10, I 2 = 46.06%).. ...
The use of A2HS as an additional polymorphic marker in paternity testing and related forensic applications is not yet introduced in the routine expertises of all laboratories. One of several causes...
article{f963b6fc-e756-4df4-ac43-a0f6062f09ae, abstract = {,p,Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that any association with sleep duration would not hold for cases of incident CHD occurring before incident diabetes (non-diabetes CHD) but would hold true for cases of incident CHD following incident diabetes (diabetes-CHD). Methods: A total of 6966 men and 9378 women aged 45-73 years from the Malmö Diet Cancer Study, a population-based, prospective cohort, who had answered questions on habitual sleep duration and did not have a history of prevalent diabetes or CHD were included in the analyses. Incident cases of diabetes and CHD were ...
In 2 separate cohorts of US men and women, 3 plasma biomarkers of dairy fat, 15:0, 17:0, and trans-16:1n-7, were associated with lower risk of incident diabetes mellitus. Findings were generally similar for erythrocyte fatty acids, although with smaller and not always significant magnitudes of association. These results provide new evidence on associations of dairy-derived circulating fatty acids and risk of diabetes mellitus.. Our findings suggest that either these dairy fatty acids themselves or other correlated factors in dairy fat could reduce the risk of diabetes mellitus. For instance, short- and medium-chain saturated fats, vitamin D (a fat-soluble vitamin), omega-3 fats, or gangliosides in dairy fat could each play a role.27 The magnitudes of our associations, linear dose response, independence from established diabetes risk factors and other dietary habits, and consistency of findings across sensitivity analyses argue against residual confounding as the sole explanation for our ...
Problem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were taken from 100 female SLE patients. All Patient samples were analyzed by ELISA for determination of Fetuin-A level. Calcium, Phosphate, C3 compelement, Lipid profile, Creatinine and urea were measured also in SLE patients compared with healthy control volunteers. Results: We found that Serum fetuin-A had been positively associated with carotid arterial stiffness, independent of known atherogenic factors in healthy subjects. Furthermore, Fetuin-A was correlated negatively with IMT, SLEDAI, CRI, CaxP product, Triglycerdies, VLDL and LDL. While it was
Complete information for AHSG gene (Protein Coding), Alpha 2-HS Glycoprotein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Results Serum FGF-23 and fetuin-A levels were significantly increased in the CAD patients as compared with the non-CAD patients (26.7 [interquartile range, 22.4-31.9] vs 15.7 [interquartile range, 13.2-18.1] pg/mL and 904.7 [interquartile range, 695.5-1021.6] vs 469.6 [331.4-660.5] mg/L, respectively; P , 0.001 for both). Furthermore, a positive correlation was identified between FGF-23 and fetuin-A levels and the total number of plaques (r = 0.21 and r = 0.28, respectively; P , 0.001 for both). In multivariate logistic regression analysis, age, smoking status, uric acid, FGF-23, and fetuin-A levels were found to be independently associated with the presence of CAD. ...
Calcium-Binding Proteins"[mesh] OR Calsequestrin* OR Fetuin* OR "alpha-2-HS-Glycoprotein" OR Calcium-Sensing OR "calcium sensing" OR Calnexin* OR Calreticulin* OR Gelsolin* OR Osteocalcin* OR Osteonectin* OR "Leukocyte L1 Antigen Complex" OR Synaptotagmin* OR S100* OR SCP* OR EF-hand OR calmodulin* OR calcineurin* OR calpain* OR visinin-like* OR "ca2-binding" OR Syt OR "synaptic vesicle protein" OR CaMKII OR "ca/calmodulin-dependent" OR Annexin OR "C2 domain" OR "Calcium ATPase" OR "Calcium pump" OR Myosin OR "Troponin C" OR cabp* OR TOUCH3 OR TCH3 OR PINOID OR pid-binding OR PBP1 OR (("phosphorylase b" OR phosphorylaseb OR phosphorylase-b OR "myosin light chain" OR cam OR NAD OR cgmp-dependent) AND (kinase OR kinases)) OR "adenylate cyclase" OR "camp phosphodiesterase" OR "NO synthase" OR "inositol 3-kinase" OR "G protein coupled receptor" OR "g protein coupled receptors" OR dystrophin OR spectrin OR fodrin OR caldesmon OR marcks OR syntrophin OR microtubule* OR myr4 OR p190 OR neuromodulin OR ...
Affiliation:愛媛大学,医学部・附属病院,講師, Research Field:Urology, Keywords:尿路結石症,プロトロンビンF1,結晶形成抑制,結石溶解,Alpha 2-HS-glycoprotein,プロトロビンF1,プロトロンビン,Prothrombin,チオバチルスチオオキシダンス,dissolution of stone, # of Research Projects:2, # of Research Products:0
Blog on AHSG elisa kit product: The Human AHSG ahsg (Catalog #MBS701816) is an ELISA Kit and is intended for research purposes only. The ...
Abcams Alpha 2 HS Glycoprotein ELISA Kit suitable for Cell culture supernatant, Milk, Urine, Serum, Plasma, Cerebral Spinal Fluid in human. Reliably quantify…
Fetuin/α2-HS glycoprotein (α2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb BgI II fragment contained exons 2, 3, and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of
Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Holen, Torgeir; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5) . doi: 10.14814/phy2.13183 Show summary The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well documented if some of the beneficial effects of exercise can be explained by altered secretion of hepatokines. The aim of this study was to examine the effect of interaction between fetuin‐A and FFAs on insulin sensitivity after ...
Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Weaving, Gary, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2011) Instability of fibroblast growth factor-23 (FGF-23): implications for clinical studies. Clinica Chimica Acta, 412 (11-12). pp. 1008-1011. ISSN 1873-3492 Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Poor agreement between commercial ELISAs for plasma fetuin-A: an effect of protein glycosylation? Clinica Chimica Acta, 411 (17-18). pp. 1367-1370. ISSN 0009-8981 Shams, Sedigheh, Shafi, Shahida, Bodman-Smith, Kikki, Williams, Peter, Mehta, Sweta and Ferns, Gordon A (2008) Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clinica Chimica Acta, 395 (1-2). pp. 42-46. ISSN 0009-8981 ...
In this study, we demonstrated that patients with type 2 diabetes who additionally suffer from PAD have significantly higher fetuin-A levels than patients with diabetes but without any atherosclerotic burden.. Our data are in opposition to the results from Eraso et al. (14), who assumed that patients with type 2 diabetes and PAD have lower plasma concentrations of fetuin-A than patients with type 2 diabetes alone. In the latter study, 738 patients with type 2 diabetes but without clinical evidence of cardiovascular disease were enrolled. From these study participants, only 5.1% (n = 38) had PAD, defined by an ABI ,0.9. Although PAD patients show the highest co-burden of manifestations of atherosclerosis (15), which is even higher in patients with PAD and type 2 diabetes (1-3,15), the 38 patients in the latter article did not show any other manifestation of atherosclerosis and must thus be regarded as highly selected and not representative (20).. In contrast to Eraso et al. (14), a decrease of ...
AAAS, AARS, AARS2, AASS, ABAT, ABCA5, ABCA7, ABCB7, ABCC8, ABCC9, ABCD1, ABCD3, ACAD9, ACADM, ACADS, ACADSB, ACMSD, ACO2, ACOT7, ACOX1, ACSF3, ACSL4, ACTB, ACTG1, ACTL6B, ACVR1, ACVRL1, ACY1, ADAM22, ADAR, ADAT3, ADCK3, ADCK4, ADD3, ADGRG1, ADK, ADNP, ADRA2B, ADSL, AFF2, AFG3L2, AGA, AGGF1, AGK, AGTR2, AHI1, AHSG, AIFM1, AIMP1, AIMP2, AKT1, AKT2, AKT3, ALAD, ALDH18A1, ALDH1B1, ALDH3A2, ALDH4A1, ALDH5A1, ALDH7A1, ALDOB, ALG1, ALG11, ALG12, ALG13, ALG2, ALG3, ALG6, ALG8, ALG9, ALMS1, ALPL, ALX4, AMACR, AMER1, AMPD2, AMT, ANK2, ANK3, ANKH, ANKLE2, ANKRD11, ANO10, ANO3, AP1S2, AP3B2, AP3D1, AP4B1, AP4E1, AP4M1, AP4S1, APC2, APOA1BP, APOPT1, APTX, AQP2, ARCN1, ARFGEF2, ARG1, ARHGAP31, ARHGEF15, ARHGEF6, ARHGEF9, ARID1A, ARID1B, ARID2, ARL13B, ARMC9, ARNT2, ARSA, ARV1, ARVCF, ARX, ASAH1, ASCL1, ASL, ASNS, ASPA, ASPM, ASS1, ASTN1, ASTN2, ASXL1, ASXL2, ASXL3, ATAD1, ATAD3A, ATIC, ATN1, ATP13A2, ATP1A2, ATP1A3, ATP2A2, ATP2B3, ATP5A1, ATP5E, ATP6AP1, ATP6AP2, ATP6V0A2, ATP6V0C, ATP6V1A, ATP6V1B2, ATP7A, ...
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Looking for online definition of alpha-2HS glycoprotein in the Medical Dictionary? alpha-2HS glycoprotein explanation free. What is alpha-2HS glycoprotein? Meaning of alpha-2HS glycoprotein medical term. What does alpha-2HS glycoprotein mean?
The selective hydrolysis of the glycosidic bond between the terminal sialic acid and the penultimate sugar has been achieved in the alpha-2-HS-glycoprotein (Fetuin-A) in the presence of H3PW12O40, a Keggin type polyoxometalate. A controlled liberation of sialic acid from the glycoprotein could be achieved at
In this 8-week randomized trial of overweight men and women, adiponectin and IL-6 levels increased for the caffeinated coffee group as compared with the group receiving no coffee. Fetuin-A levels decreased for decaffeinated coffee as compared with no coffee at the end of the intervention. There were no significant differences between the three treatment groups for CRP or measures of glucose metabolism.. Our results for adiponectin are consistent with one observational study and non-randomized trial that found higher adiponectin concentrations with increasing coffee consumption [8, 10]. The effects of coffee on fetuin-A concentrations in our trial are consistent with the beneficial effects of coffee on liver function suggested by cross-sectional studies of coffee consumption and liver enzymes [9]. The lack of significant effects of coffee consumption on glucose tolerance may seem inconsistent with the effect of coffee consumption on adiponectin levels and the association between increases in ...
Approach and Results-Immunohistochemistry and quantitative polymerase chain reaction showed that GRP expression and accumulation are upregulated with calcification simultaneously with osteocalcin and matrix Gla protein (MGP). Using conformation-specific antibodies, both γ-carboxylated GRP and undercarboxylated GRP species were found accumulated at the sites of mineral deposits, whereas undercarboxylated GRP was predominant in calcified aortic valve disease valvular interstitial cells. Mineral-bound GRP, MGP, and fetuin-A were identified by mass spectrometry. Using an ex vivo model of vascular calcification, γ-carboxylated GRP but not undercarboxylated GRP was shown to inhibit calcification and osteochondrogenic differentiation through α-smooth muscle actin upregulation and osteopontin downregulation. Immunoprecipitation assays showed that GRP is part of an MGP-fetuin-A complex at the sites of valvular calcification. Moreover, extracellular vesicles released from normal vascular smooth muscle ...
A Fetuin subtype that is synthesized by Hepatocytes and secreted into the circulation. It plays a major Role in preventing Calcium precipitation in the Blood ...
Kaufmann-Peterson [base]; Keratitic Precipitate; Keratitis Punctata; Kidney Protein; Killed Parenteral [vaccine]; Klebsiella ...
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Approach and Results-We adapted Egger regression, a technique frequently used in Mendelian randomization studies to detect genetic pleiotropy, to reanalyze the available randomized control trial data of statin therapy. For cardiovascular end points, each 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 0.77 (95% confidence interval, 0.71-0.84) with an intercept that was indistinguishable from zero (intercept, −0.0032; [95% confidence interval, −0.090 to 0.084]; P=0.94), indicating no pleiotropy. For incident diabetes mellitus, a 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 1.07 (95% confidence interval, 0.99-1.16) and an intercept nondistinguishable from zero (intercept, −0.015; [95% confidence interval, −0.30 to 0.27]; P=0.91), again indicating no pleiotropy. ...
Rancho Bernardo Yoga teachers include Jeanne Stone, Lori Cota, Sarah Gutz, Erin VandenBergh, Mary Beth Schrepferman, Becky MacBain, and Debra Logan
Ahaneku G.I., Osuji C.U., Anisiuba B.C., Ikeh V.O., Oguejiofor O.C. and Ahaneku J.E., (2011). Evaluation of blood pressure and indices of obesity in a typical rural community in eastern Nigeria. Ann. Afr. Med. 10 (2): 120-6.. Allain C.C., Poon L.S., Chain C.S.G., Richmond W,. and Fu P.C., (1974). Enzymatic etermination of the serum cholesterol. Clin. Chem. 20(4): 470-475.. Barham D. and Trinder P., (1972). Clinical guide to laboratory test. Analyst 97: 142.. Barzilay J.I., Davis B.R., Cutler J.A., Pressel S.L., Whelton P.K., Basile J., Margolis KL., Ong S.T., Sadler L.S. and Summerson J., (2006). Fasting glucose levels and incident diabetes mellitus in older non-diabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT). Ach. Intern. Med. 166(20): 2191-2201.. Benson S.C., Pershadsingh H.A., Chittiboyina A., Desai P., Pravenec M., Qi N., Wang J., Avery M.A. and ...
Under normal conditions, several calcification inhibitors, including pyrophosphate, adenosine, matrix Gla protein, osteopontin, fetuin-A, osteoprotegerin, and bone morphogenetic protein-7, protect against abnormal mineral deposition in the vessel wall, whereas hypercalcemia, increased levels of parathyroid hormone, inflammatory cytokines, oxidative stress, uremic toxins, advanced glycation end-products, and, most importantly, phosphates induce vascular calcification. During CKD there is an imbalance between inhibitors and inducers of vascular calcification.24 Phosphates increase during CKD because of progressively reduced renal excretion. High phosphate levels may directly induce vascular calcification via the activation of Toll-like receptor 4/NF-κ light-chain enhancer of activated B cells (NF-κB) signaling in VSMCs.25 Moreover, in the presence of high phosphate levels, VSMCs can change their phenotype into osteoblast-like cells via the loss of smooth muscle markers (e.g., α-smooth muscle ...
Calciphylaxis CUA Calciphylaxis Metastatic systemic calcifications after invasive manipulation of animal model No vascular calcifications found CUA Occurs in presence of uremia Abnormalities in divalent ion ie PTH, Ca, PO4 (not required) Vascular calcifications at site of lesions
The most recent Cochrane reviews highlight no benefit in terms of pain relief or physical function from arthroscopic washout or debridement for patients with osteoarthritis of the knee.3 4 Two meta-analyses also suggest no benefit,5 6 with the most recent noting that arthroscopy is not without hazard and that this should be considered in the light of poor efficacy.6 Arthroscopic menisectomy does, however, have a role in specific patients. A recent randomised study in patients with no signs of osteoarthritis on plain radiography but who had persisting medial joint line knee pain despite conservative management found that meniscal resection was beneficial.7 Current guidance from the National Institute for Health and Care Excellence (NICE) suggests that referral for arthroscopic lavage and debridement should not be offered unless the person has a clear history of mechanical locking.1 But in a poll on thebmj.com after the most recent meta-analysis was published, 70% of respondents thought … ...
Contrary to the general assumption, we found that PPi has bioavailability in humans and mice when administered orally (Fig 1). The observed transient elevation found in healthy volunteers (Fig 1A) indicates that in both GACI and in PXE patients, PPi levels may be transiently raised to the physiological level when 67 or 98 mg Na4PPi/kg of body weight is taken. Importantly, it has been shown that inhibition of calcification in uremic rats and in PXE mice can be achieved by daily intraperitoneal injections of PPi triggering transient increase in plasma PPi levels (ONeill et al, 2011; Pomozi et al, 2017). We determined a t1/2 = 44.7 min what is rather similar to that published in rat (34.1 min; ONeill et al, 2011).. We also demonstrated significant attenuation of calcification in two different well‐characterized mouse models of ectopic calcification disorders, PXE and GACI when the animals were treated with pyrophosphate orally. Furthermore, we demonstrated PPi uptake from the oral cavity and ...
Ectopic calcification as very well as fatty and fibrotic tissues accumulation occurs in skeletal muscle during the disease development of Duchenne buff dystrophy (DMD), a degenerative muscle disorder caused by mutations in the dystrophin gene. the nmMSCs become turned on during the disease development in dKO rodents, exhibiting elevated growth and difference possibilities (adipogenesis, osteogenesis and fibrogenesis). We discovered that after co-culturing the dKO-nmMSCs with dKO-MPCs also, the myogenic difference potential of the dKO-MPCs was decreased. This impact was discovered to end up being possibly mediated by the release of secreted frizzled-related proteins 1 by the dKO-nmMSCs. We posit that the speedy incidence of fibrosis as a result, ectopic calcification and fats deposition, in dKO rodents, is certainly not really just attributable to the speedy exhaustion of the MPC pool, but is certainly also the effect of nmMSC account activation. Outcomes from this research recommend that methods ...
BACKGROUND: In patients with dilated (idiopathic) cardiomyopathy (DCM), little is known about the presence of valvular calcification and its association with hypovitaminosis D, which may predispose affected tissues to calcification. Our objectives were 2-fold: to conduct a retrospective assessment of echocardiographic evidence of valvular calcification in patients with DCM who were known to have hypovitaminosis D (25(OH)D ...
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Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT ...
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Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P = 9.0x10(-10)), a finding that was replicated in additional white European, ...
Blood Work: At Quail Valley Veterinary Clinic, we have in house blood machines that allow us to run many tests very quickly. We have a chemistry analyzer that allows us to check your pets organ functions, cbc machine that gives us blood cell counts, and a thyroid analyzer. This allows us to get very quick answers and determine what may be the best treatment for your pet. We also send more specialized blood work to regional labs.. Radiology: We have a full line of radiography equipment, including both stationary and mobile units. We have the ability to perform specialized procedures such as contrast studies that help detect problems not readily visible on plain radiography films.. Routine Fecals: A stool sample can be analyzed to check for intestinal parasites. This is especially important in puppies and kittens and dogs and cats with loose stools. Learn More ». Routine Urinalysis: Urinalysis testing for urinary tract infections and kidney disease are also routinely performed. Learn More ...
Osteoclast like cells are demonstrable in heart valves and in arterial vessels. Their ability to affect phosphate metabolism is documented by their alkaline phosphatase activity. It is interesting to note that this activity is much enhanced when these cells are co-cultured with monocyte macrophages thus providing a link between inflammation and vascular calcification. On the other hand in heart valves and arterial vessels as well there is a true process of ossification. When we have true lamellar bone, inhibitors of calcification are important, particularly so in patients with ESRD. In this regard Fetuin is a most interesting calcification inhibitor and inverse acute phase reactant. When Fetuin is low inflammation and calcification should be more likely. In agreement with this hypothesis Ketteler has recently shown that CV events free survival is shorter in patients with low Fetuin than in those with relatively higher values. ...
Other Cytokine Receptors: Cntfr, Csf2ra, Csf3r, Ebi3, Epor, F3, Gfra1, Gfra2, Ghr, Ifnar1, Ifnar2, Ifngr1, Ifngr2, Lepr, Lifr, Mpl, Osmr, Prlr, Ttn. Cytokine Metabolism: Apoa2, Cd27 (Tnfrsf7), Cd28, Cd4, Cd86, Cebpb, Glmn, Ifnar1, Ifng, Il10, Il12b, Il17f, Il18, Il19, Il1b, Il1rap, Il21, Il27, Il4, Il6, Inha, Inhba, Inhbb, Irf4, Irf7, Myd88, Nfkb1, Nlrp12, Prg3, S100b, Sftpd, Sigirr, Syk, Tlr1, Tlr2, Tlr3, Tlr4, Tlr6, Tnfsf15.. Cytokine Production: Apoa2, Cd27 (Tnfrsf7), Cd28, Cd4, Cd86, Cebpb, Ebi3, Glmn, Ifnar1, Ifng, Il10, Il12b, Il17f, Il18, Il19, Il1b, Il1rap, Il21, Il27, Il4, Il6, Inha, Inhba, Inhbb, Irf4, Irf7, Myd88, Nfam1, Nfkb1, Nlrp12, Prg3, Ptafr, S100b, Sftpd, Sigirr, Syk, Tlr1, Tlr2, Tlr3, Tlr4, Tlr6.. Cytokine-Cytokine Receptor Interaction: Ccr1, Cd40 (Tnfrsf5), Cxcr3, Il18rap, Il23r, Xcr1.. Acute-Phase Response: Ahsg, Apcs, Cebpb, Crp, F2, F8, Fn1, Il22, Il6, Ins1, Ins2, Itih4, Lbp, Reg3a, Reg3g, Saa4, Serpina1a, Serpina3n, Serpinf2, Sigirr, Stat3.. Inflammatory Response: Adora1, ...
Search Software Development Engineer In Test (SDET) jobs in Rancho Bernardo, CA. 667 open jobs in Rancho Bernardo for Software Development Engineer In Test (SDET). Average Salary: $89,731.
Die Schmid Stiftung bietet Pro-bono-Angebote im Bereich Organisationsentwicklung für Non-Profit-Organisationen an. Unter dem Motto OE im Dialog gibt es versc...
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The best Broadway Singing lessons in Rancho Cordova, CA as rated by students. Browse Rancho Cordova Broadway Singing teachers - ask questions, read reviews & compare rates!
Moon-van der Staay, S.Y. ; Staay, G.W. van der; Michalowski, T.; Jouany, J.P.; Pristas, P.; Javorsky, P.; Kisidayova, S.; Varadyova, Z.; McEwan, N.R.; Newbold, C.J.; Alen, T. van; Graaf, R. de; Schmid, M.; Huynen, M.A. ; Hackstein, J.H. et al ...
A. Heidenreich, J. Bellmunt, M. Bolla, S. Joniau, M. Mason, V. Matveev, N. Mottet, H.P. Schmid, T. van der Kwast, T. Wiegel, F. Zattoni ...
Discover the businesses found at 30520 Rancho California Rd Temecula, CA 92591. We have found 100 companies and 100 people at this address.
Raffaella G., Sole,C., Llecha,N, Segura, M.F., Moubarak,R., Iglesias-Guimarais,V., Perez-Garcia,M.J., Reix,S., Zhang,J., Badiola,N., Sanchis,D., Rodriguez-Alvarez,J.,Trullas,R., Yuste,V.J., and J.X. Comella ...
A coating and integral treatment for improving the biophysical stability of bioprosthetic devices after implantation, particularly with respect to calcification, and, specifically, a method for treating animal tissues, such as heart valves, to provide improved biophysical stability in allograft and heterograft transplantations. The increased stability results, in-part, from the creation of a three-dimensional matrix of a primary structural component of the prosthetic device and covalently attached calcification inhibitors. Other materials, some having additional stabilizing effects, may be utilized to form additional bridges or fill the interstitial gaps in the matrix. After implantation, the resultant modified device exhibits minimal surface for intramatrix growth of calcium phosphate crystals, and additionally, may inhibit platelet aggregation, enzymatic degradation and host rejection, while minimizing the risk of mechanical failure, in the host organism.
To elucidate the causal mechanisms and the resulting changes, DZD researchers of the Institute for Diabetes Research and Metabolic Diseases (IDM) of Helmholtz Zentrum München at the University of Tübingen studied the influence of fetuin-A on pancreatic adipose tissue. Approximately one-third of the pancreatic adipose tissue consists of adipose precursor cells (a kind of stem cells) in addition to the mature adipose cells. If the pancreatic adipose cells are treated with fetuin-A in cell cultures*, the mature adipose cells - but in particular the adipose precursor cells in interaction with the islet cells - increasingly produce inflammation markers and immune-cell-attracting factors.. In addition, the researchers histologically analyzed tissue samples from 90 patients and found that the proportion of the pancreatic fat varied greatly. The number of defense cells of the immune system (monocytes / macrophages) was significantly increased in areas where many adipose cells had accumulated.. In a ...
Rancho Bernardo Solar Company Cutting 100 Jobs A French electronics firm that opened a solar energy plant in Rancho Bernardo to great local fanfare 3 year
As well as operating a daily humor website, we also publish Timothy McSweeneys Quarterly Concern, Illustoria and an ever-growing selection of books under various imprints. You can buy all of these things from our online store. You can support us today by making a donation ...
We can tell you all about the nice ambience and how great the view at Rancho Beach. But we rather let our guests tell you. Read some references and let them convince you!
We can tell you all about the nice ambience and how great the view at Rancho Beach. But we rather let our guests tell you. Read some references and let them convince you!
Müller T., Philipp A., Luchner A., Karagiannidis C., Bein T., Hilker M., Rupprecht L., Langgartner J., Zimmermann M., Arlt M., Wenger J., Schmid C., Riegger G AJ, Pfeifer M., Lubnow M ...
Thiede, J. , Timokhov, L. , Bauch, H. A. , Bolshiyanov, D. , Dmitrenko, I. , Eicken, H. , Fahl, K. , Gukov, A. , Kassens, H. , Melles, M. , Petryashov, V. , Pivovarov, S. , Priamikov, S. , Rachold, V. , Schmid, M. , Siegert, C. , Spindler, M. , Stein, R. , Hölemann, J. , Scientific Party, Hubberten, H. W. and Juterzenka, K. v. (1999 ...
Herrera, Fernando E.; Chesi, Alessandra; Paleologou, Katerina E.; Schmid, Adrian; Munoz, Adriana; Vendruscolo, Michele; Gustincich, Stefano; Lashuel, Hilal A.; Carloni, Paolo (PLoS, 2008-10-14) ...
Wachter, Britta; Schmid, Andreas; Speidel, Anna; Rolinger, Jens; Pichler, Bernd; Berg, Daniela; Wagner, Hans-Joachim; Ameln-Mayerhofer, Andreas von; Schürger, Sonja; Gröger, Adriane; Sadler, Rüdiger; Küppers, Eva (2012) ...
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Wang PH, Schwindt TT, Barnabé GF, Motta FL, Semedo P, Beraldo FC, Mazzali M, Dos Reis MA, Teixeira VD, Pacheco-Silva A, Mello LE, Câmara NO ...
Two brothers aged 10 years and 18 years presented with multiple soft tissue calcareous swellings around the elbows, arms, knees, and forearms, which had been present for the last three years. Both were in good general health and there was no history of trauma. On examination, the younger boy had a calcified soft tissue swelling around the left knee joint with a sinus around the medial side of the knee. There was occasional discharge of white chalky material from the sinus. Movements at the knee were full and there was no neurovascular problem. The other brother had calcareous, firm, soft tissue swellings over the right lower thigh, left and right arms, and around both the elbow joints. Movements at the elbow and knee joints were normal and he had no discharging sinus. Their serum calcium, serum phosphorus, alkaline phosphatase, and urinary calcium were within normal limits. The erythrocyte sedimentation rate and the leukocyte count were normal. A test for lupus erythematosus was negative and ...
A sialolith is a stone (salivary calculus) within a salivary gland or duct. The formation of a sialolith is called sialolithiasis and occurs as a result of precipitation of calcium andphosphate salts around a nidus of mucous or bacterial debris. Sialoliths occur as single or multiple stones and can cause swelling and pain. The pain is experienced during salivary stimulation and is intensified at mealtimes. The accumulation of saliva in the gland produces swelling and the gland becomes enlarged and firm. The pain is produced as a result of the buildup of pressure due to the accumulation of saliva behind the stone. The pain gradually subsides and the swelling diminishes because the stone usually does not completely block the flow of saliva. If a sialolith is small or does not obstruct the flow of saliva, there may be an absence of pain and swelling. Most stones are found in the submandibular duct (Whartons) and gland than in the parotid duct (Stensens) and gland because of the viscous ...
Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as part of several monogenic disorders and studies of these have provided valuable insights into the metabolic pathways regulating mineral metabolism. For example, studies of tumoural calcinosis, a disorder characterised by hyperphosphataemia and progressive EC, have revealed mutations of fibroblast growth factor 23 (FGF23), polypeptide N-acetyl galactosaminyltransferase 3 (GALNT3) and klotho (KL), which are all part of a phosphate-regulating pathway. However, such studies in humans are limited by the lack of available large families with EC, and to facilitate such studies we assessed the progeny of mice treated with the chemical mutagen N-ethyl-N-nitrosourea (ENU) for EC. This identified two mutants with autosomal recessive
Ectopic calcification (EC) is a complex disease in which mineral develops in abnormal locations. It can develop in a variety of locations throughout the body, including the vasculature, heart valves, and in orthopedic settings where it is more commonly referred to as heterotopic ossification (HO). Current therapies for these conditions are limited and new treatment modalities would benefit a wide variety of patients. Osteoclasts resorb mineral in vivo and we hypothesized that a cell therapy based on inducible osteoclast differentiation could be used as a cell therapy to treat EC and HO. The RANK/RANKL pathway is a critical step in osteoclast differentiation and we created an inducible RANK (iRANK) fusion protein which could be activated by a small molecule chemical inducer of dimerization (CID). This fusion protein was introduced into a macrophage cell line, and the resulting RAW264.7+iRANK cells were characterized using in vitro assays. In the presence of CID, the cells formed large, ...
Alignment of cystatin superfamily domain.The domain was aligned using ClustalW and adjusted manually. (A) The three parts of the papain binding domain (G, QXVXG
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Vitamin D toxicity can cause non-specific symptoms such as anorexia, weight loss, polyuria, and heart arrhythmias. More seriously, it can also raise blood levels of calcium which leads to vascular and tissue calcification, with subsequent damage to the heart, blood vessels, and kidneys [1]. The use of supplements of both calcium (1,000 mg/day) and vitamin D (400 IU) by postmenopausal women was associated with a 17% increase in the risk of kidney stones over 7 years in the Womens Health Initiative [67]. A serum 25(OH)D concentration consistently ,500 nmol/L (,200 ng/mL) is considered to be potentially toxic [5 ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Sounders midfielder Steve Zakuani jogged on the side today, one day after missing training entirely due to a blood test.. However, after training coach Sigi Schmid clarified that the issue today is a groin injury and not anything to do with the blood-test results. Yet the groin injury apparently is significant enough where Zakuanis status for the Saturday game at Philadelphia isnt yet known. "I didnt mean to alarm the world when I said he needed to go in for a blood test," Schmid said. "It wasnt anything major. So he was out here. Djimi did more today. Burch did more today. Now well see how they do tomorrow. … (Zakuani) has a little bit of an injury in his groin area, so it matters how he came through today and how he feels tomorrow." Schmid was asked if he expects to be able to choose from a full roster Saturday at Philadelphia.. "I dont know with those three guys: With Djimi and Steve and Burchy well be able to decide more tomorrow," he said. "Ianni is still trying to work his way ...
With advancing age, diabetes, impaired renal function, and hypertension, conduit arteries become increasingly arteriosclerotic, losing compliance necessary for...
Associations were found between rs9919713 and fasting glucose (P = 2.3 x 10-4) and type-2 diabetes (P = 9.0 x 10-3) in Mexican-American women. In Mexican-American men from the Rancho Bernardo population, the opposite effect was found.[PMID 20085651 ...
Miyazaki, Y., Irobalieva, R.N., Tolbert, B.S., Smalls-Mantey, A., Iyalla, K., Loeliger, K., DSouza, V., Khant, H., Schmid, M.F., Garcia, E.L., Telesnitsky, A., Chiu, W., Summers, M.F ...
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Many guests voice their concerns that there is not enough protein given the volume of exercise. You are really getting more protein here than you think.
Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation. This response is called the acute-phase reaction (also called acute-phase response). The terms acute-phase protein and acute-phase reactant (APR) are often used synonymously, although some APRs are (strictly speaking) polypeptides rather than proteins. In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL1, IL6 and IL8, and TNFα. The liver responds by producing a large number of acute-phase reactants. At the same time, the production of a number of other proteins is reduced; these proteins are, therefore, referred to as "negative" acute-phase reactants. Increased acute-phase proteins from the liver may also contribute to the promotion of sepsis. Positive acute-phase ...
International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.
60 year old male referred to orthopedic surgeon with painful lower limb with multiple swellings after a crural fracture and compartment syndrome decompression in the distant past. The soft tissue calcifications seen on this CT and MRI can be adeq...
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SPEAGs Torso-OTA-V5.1 is a homogeneous anthropomorphic torso phantom filled with a broadband tissue simulating gel for OTA (over-the-air) evalution of wireless devices for which the effect of the body can not be neglected such as hand-held and on-body devices.
Integrative Pediatrics with Dr. Lindy Woodard; The Power of Food As Medicine with Dr. Nick Gonzalez & Dr. Ron Schmid; Gratefulness as a Healing Practice with Dr. Brenda Wade. Visit the Website: www.healingquest.tv Episode #1001 / Length: 26 minutes. ...
Schmid, Stefan Patrick; Schleicher, Erwin; Baur, Stephanie Maria; Hauser, Ann-Kathrin; Synofzik, Matthis Benjamin; Srulijes, Karin; Brockmann, Kathrin; Berg, Daniela; Maetzler, Walter; Deuschle, Christian (Hoboken, NJ : Wiley-Blackwell, 2012) ...
CrossFit Kinnick has Locations in Ontario and Upland. We also serve Eastvale, Chino Hills, Rancho Cucamonga, and Claremont. We offer Olympic Weightlifting, Powerlifting, and Running Classes.
CrossFit Kinnick has Locations in Ontario and Upland. We also serve Eastvale, Chino Hills, Rancho Cucamonga, and Claremont. We offer Olympic Weightlifting, Powerlifting, and Running Classes.
A leader among scientists, Sandra Schmid, Ph.D., was named Chair of the Department of Cell Biology in 2011. Dr. Schmid is committed to mentoring young scientists and gives career development and time management seminars to postdoctoral fellows and junior faculty nationwide. Her research focuses on clathrin-mediated endocytosis, the major pathway for uptake into the cell, with a particular emphasis on the GTPase dynamin. Dr. Schmid was co-founding editor of Traffic, Editor-in-Chief of Molecular Biology of the Cell, and is a past president of the American Society for Cell Biology (ASCB). Her awards include an ASCB/ WICB Junior Career Recognition Award, an NIH MERIT Award, and the William C. Rose Award from the American Society for Biochemistry and Molecular Biology. She is a Fellow of AAAS. Dr. Schmid earned her doctorate at Stanford University and recently earned a Master of Science in Executive Leadership at the University of San Diego. She came to UT Southwestern from The Scripps Research ...
Introduction Cardiovascular disease is the leading cause of mortality in patients with end-stage renal disease (ESRD) and is attributed to a combination of traditional and nontraditional risk factors. In recent years, there has been an increasing recognition of a very high prevalence of cardiovascular calcification in the ESRD population, including patients receiving hemodialysis (HD) and peritoneal dialysis. The mechanism is multifactorial, including structural and functional abnormalities in the large vessels, disorders in calcium (Ca2+) and phosphate (P) metabolism, vascular smooth muscle cells changes, and regulatory markers such as fetuin-A and osteoprotegerin (OPG). Aim of the work The aim of the present study was to determine the utility of multislice computed tomography (MSCT) for the assessment of coronary artery calcifications (CACs) and to identify the potential risks for CAC, including calcification regulating proteins such as fetuin-A and OPG, among patients with ESRD on maintenance ...
With Mg depletion, Ca can migrate to parts of your body where it doesnt belong. It can cause spasms in your muscles and that includes your heart muscle, it will make plaque sticky and harden your arteries, it will go to your kidneys and cause kidney stones. Other symptoms are fibromyalgia, tooth decay, breast tissue calcification, heart arrhythmias, angina, mitral valve problems, migraines and headaches, Ca deposits in the bladder, causing rigidity and lowering of bladder capacity, digestive problems including constipation. But one of the most common symptoms of a Mg deficiency is high blood pressure. The first time your BP starts to rise, a simple good quality Mg supplement such as ReMag or Ionic Magnesium, will keep BP at optimum levels for your body. Taking a hypertensive drug at the first onset of prehypertension is best delayed until you have tried a natural solution. Otherwise you may be on the first step to taking these drugs for the rest of your life, along with their side ...
TY - JOUR. T1 - Intra-operative radiotherapy management for breast cancer treatment in patients with pseudoxanthoma elasticum. T2 - A case report. AU - Salerno, Carmela. AU - Vento, Anna Rita. AU - Giacchino, Maria. AU - Lissidini, Germana. AU - Galimberti, Viviana. AU - Corso, Giovanni. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Pseudoxanthoma elasticum is a systemic metabolic disease presenting calcifications and progressive fragmentation of elastic fibers. Actually, no targeted therapies are available for the treatment; only prevention of complications is possible. Classically, pseudoxanthoma elasticum is a "benign" disease, without cancer association. Herein, we reported a singular association of pseudoxanthoma elasticum with breast carcinoma, describing the clinical management, in particular intra-operative treatment, focusing on intra-operative radiotherapy since no specific guidelines are available in literature.. AB - Pseudoxanthoma elasticum is a systemic metabolic disease presenting ...

Alpha-2-HS-glycoprotein - WikipediaAlpha-2-HS-glycoprotein - Wikipedia

Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two ... 1986). "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein". J. Biol. Chem. 261 (4): 1665- ... 2001). "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene". Ann. Hum. Genet. 65 (Pt 1): 27-34. doi:10.1046/j ... 1983). "Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary ...
more infohttps://en.wikipedia.org/wiki/Alpha-2-HS-glycoprotein

AHSG Gene - GeneCards | FETUA Protein | FETUA AntibodyAHSG Gene - GeneCards | FETUA Protein | FETUA Antibody

Alpha 2-HS Glycoprotein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily) *AHSG ... Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M … Takeichi S (Gene 1997) 2 3 4 22 ... Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are ...
more infohttp://www.genecards.org/cgi-bin/carddisp.pl?gene=AHSG

KAKEN - Researchers | TAKEDA Hajime (80294792)KAKEN - Researchers | TAKEDA Hajime (80294792)

Alpha 2-HS-glycoprotein,プロトロビンF1,プロトロンビン,Prothrombin,チオバチルスチオオキシダンス,dissolution of stone, # of Research Projects: ... 尿路結石症 / 結晶形成抑制 / チオバチルスチオオキシダント / Alpha 2-HS-glycoprotein / プロトロビンF1 / プロトロンビン / Calcium phosphate crystals / bacteria / ... dissolution of stone / チオバチルスチオオキシダンス … More / オステオポンチン / アルファース-HS-糖蛋白 / α_2-HS糖蛋白 / バクテリア / Osteopontin / アルファ-2-HS-糖蛋
more infohttps://nrid.nii.ac.jp/nrid/1000080294792/

Development of Novel Therapies for Liver Disease Associated with Misfolded Z Alpha-1-Antitrypsin Accumulation and DisposalDevelopment of Novel Therapies for Liver Disease Associated with Misfolded Z Alpha-1-Antitrypsin Accumulation and Disposal

Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD. Genome editing with engineered zinc finger nucleases. Nature Reviews ... In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol 2002;76:937 ... Albumin, alpha fetal protein (AFP), and alpha 1 antitrypsin (AAT) expression were detected in both cell lines, which are key ... Elevated synthesis of human alpha 1antitrypsin hinders the secretion of murine alpha 1antitrypsin from hepatocytes of transg ...
more infohttps://ufdc.ufl.edu/UFE0044879/00001

Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)

Abcams Alpha 2 HS Glycoprotein ELISA Kit suitable for Cell culture supernatant, Milk, Urine, Serum, Plasma, Cerebral Spinal ...
more infohttp://www.abcam.com/human-fetuin-a-elisa-kit-ahsg-ab108855.html

antibodies-Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum-Genemed Synthesis Inc.antibodies-Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum-Genemed Synthesis Inc.

Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum antibodies FETB11-S ... Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum antibodies FETB11-S Anti-Bovine Fetuin ( ... Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum. Catalog#. Product Description. Product Type. Antibody Type ... Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum. antibodies. 100 ul. $325.00 ...
more infohttp://genemedsyn.com/ccpc1034-12703-anti-bovine-fetuin-28alpha-2-hs-glycoprotein--ahsg-antibodies-fetb11-s.htm

Primary Antibodies-Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG-Alpha Diagnostic International Inc.Primary Antibodies-Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG-Alpha Diagnostic International Inc.

Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG Primary Antibodies FETA14-M ... Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG Primary Antibodies FETA14-M Monoclonal Anti-Mouse Fetuin A ( ... Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG. Primary Antibodies. Mono-Rat. 100 ug. $355.00 ... Alpha Diagnostic Intl. Inc., 6203 Woodlake Center , San Antonio, Texas 78244 USA. Toll Free: (800)-786-5777 , 210-561-9515 , ...
more infohttp://4adi.com/ccp17054-monoclonal-anti-mouse-fetuin-a-28alpha-2-hs-glycop-primary-antibodies-feta14-m.htm

alpha-2-HS-glycoprotein 2 - Creative Biogenealpha-2-HS-glycoprotein 2 - Creative Biogene

AHSG2; alpha-2-HS-glycoprotein 2; fb60d10; wu:fb60d10; si:cu104710.4; si:ch73-252g14.4 ...
more infohttps://www.creative-biogene.com/genesearch/AHSG2.html

Browse our Fetuin A ELISA KitsBrowse our Fetuin A ELISA Kits

... alpha2-HS glycoprotein , Alpha-2-HS-glycoprotein ... alpha-1-B Glycoprotein ELISA Kits * alpha- and gamma-Adaptin ... Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists ... Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. Additionally we are shipping ... glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , fetuin , alpha-2-HS glycoprotein , pre-pro polypeptide (AA -18 to -346 ...
more infohttps://www.antibodies-online.com/abstract/alpha-2-HS-Glycoprotein+

Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...

Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-a in plasma from neonates with intrauterine ... AHSG: alpha-2-HS glycoprotein; ALB: albumin; APOA1: apolipoprotein A1; TF: transferrin Least squares means sharing a common ... The abundance of Rho GDP-dissociation inhibitor alpha (ARHGDIA) was reduced for 110-day-old fetuses compared with 90-day-old ... Laborda J, Naval J, Calvo M, Lampreave F, Uriel J. Alpha-fetoprotein and albumin uptake by mouse tissues during development. ...
more infohttps://link.springer.com/article/10.1186/s40104-018-0244-2

GO Gene ListGO Gene List

Hs; negative regulation of growth; UniGene Build:. Hs.234/Mm.193. [Text]. [Clones]. ... Glycoprotein hormones, alpha polypeptide. NM_001252383. NM_000735. Gene Info. CGREF1. Cell growth regulator with EF-hand domain ... Glycogen synthase kinase 3 alpha. NM_019884. Gene Info. HIF1A. Hypoxia inducible factor 1, alpha subunit (basic helix-loop- ... Crystallin, alpha B. NM_001885. Gene Info. CTH. Cystathionase (cystathionine gamma-lyase). NM_001902. NM_001190463. NM_153742. ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0045926

GO Gene ListGO Gene List

Hs.234/Mm.193. [Text]. [Clones]. Displaying 1 thru 300 of 1752 items Go to page: 1 2 3 4 5 6 ... Glycoprotein hormones, alpha polypeptide. NM_001252383. NM_000735. Gene Info. CGN. Cingulin. NM_020770. Gene Info. ... Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase). NM_ ... ATPase, Cu++ transporting, alpha polypeptide. NM_000052. Gene Info. ATXN3. Ataxin 3. NM_004993. NM_001127696. NM_001127697. NM_ ...
more infohttps://cgap.nci.nih.gov/Genes/GoGeneQuery?PAGE=1&ORG=Hs&GOID=0070887

SMART: CY domain annotationSMART: CY domain annotation

Alpha-2-HS-glycoprotein (P02765) (SMART). OMIM:138680: ALPHA-2-HS-GLYCOPROTEIN; AHSG. ... However, some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: ...
more infohttp://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=CY&BLAST=DUMMY

AHSG - PrimePCR Assay and Template | Life Science | Bio-RadAHSG - PrimePCR Assay and Template | Life Science | Bio-Rad

Alpha2-HS glycoprotein (AHSG) a glycoprotein present in the serum is synthesized by hepatocytes. The AHSG molecule consists of ... alpha-2-HS-glycoprotein Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5017746 Info: EG; Same primer ... alpha-2-HS-glycoprotein Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5049848 Info: FAM; Same primer ... alpha-2-HS-glycoprotein Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5049849 Info: HEX; Same primer ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/gene/ahsg-human

SMART: CY domain annotationSMART: CY domain annotation

Alpha-2-HS-glycoprotein (P02765) (SMART). OMIM:138680: ALPHA-2-HS-GLYCOPROTEIN; AHSG. ... However, some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: ...
more infohttp://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=SM00043

ENSDARG00000069293 - Zebrafish Mutation Project - Wellcome Sanger InstituteENSDARG00000069293 - Zebrafish Mutation Project - Wellcome Sanger Institute

alpha-2-HS-glycoprotein [Source:HGNC Symbol;Acc:349]. Mouse Orthologue:. Ahsg. Mouse Description:. alpha-2-HS-glycoprotein Gene ... 2. 10136396. KASP Assay ID:. None (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. None. Flanking ... 2. 10134635. KASP Assay ID:. None (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. ... 2. 10136046. KASP Assay ID:. 554-1793.1 (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. ...
more infohttps://www.sanger.ac.uk/sanger/Zebrafish_Zmpgene/ENSDARG00000069293

Ahsg - ddPCR Probe - Digital PCR | PrimePCR | Bio-RadAhsg - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad

Alpha-2-HS-glycoprotein precursor Aliases:. Not Available. RefSeq:. NM_012898. Ensembl:. ENSRNOG00000038370 ...
more infohttp://www.bio-rad.com/en-us/prime-pcr-assays/assay/drnocpe5148180-primepcr-ddpcr-expression-probe-assay-ahsg-rat

CAIRO LIVER DEVELOPMENT DNCAIRO LIVER DEVELOPMENT DN

collagen, type XVIII, alpha 1. 1418239_at. 319. APOF. apolipoprotein F. 1418267_at. 4485. MST1. macrophage stimulating 1 ( ...
more infohttp://software.broadinstitute.org/gsea/msigdb/cards/CAIRO_LIVER_DEVELOPMENT_DN.html

Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension | ThoraxReduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension | Thorax

A2AP, alpha-2-antiplasmin; Apo, apolipoprotein; A2SG, alpha-2-HS-glycoprotein; CNDP1, carnosine dipeptidase 1; FXI, factor XI; ... Prekallikrein formed a central hub connecting small HDL-4 particle to factor XI and alpha-2-antiplasmin (all p,0.0001, figure ... Five of the nine proteins, namely, Apo A-1, alpha-2-antiplasmin, coagulation factor XI, afamin and alpha-2-HS-glycoprotein, ... Only five out of nine identified proteins (alpha-2-antiplasmin, alpha-2-HS-glycoprotein, afamin, coagulation factor XI and Apo ...
more infohttps://thorax.bmj.com/content/early/2018/11/26/thoraxjnl-2018-212144

Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |...Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |...

... while alpha-2-macroglobulin and ceruloplasmin were lower (p < 0.05). C3adesArg and ITIH4 have previously been related to the ... apolipoprotein E and isoform 1 of inter-alpha trypsin inhibitor heavy chain H4 (ITIH4) were found to be higher in pre- ... In the 1980s however, the acute phase proteins alpha-2-macroglobulin and ceruloplasmin were already studied in relation to ... To our knowledge, afamin, apolipoprotein E, alpha-2-macroglobulin and ceruloplasmin have not been found before to differ ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-381

Baik SH[au] - PubMed - NCBIBaik SH[au] - PubMed - NCBI

Oh TJ, Yu JM, Min KW, Son HS, Lee MK, Yoon KH, Song YD, Park JY, Jeong IK, Cha BS, Kim YS, Baik SH, Kim IJ, Kim DM, Kim SR, Lee ... Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ... Chung HS, Lee HJ, Hwang SY, Choi JH, Yoo HJ, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH, Choi KM. ... Chung HS, Hwang SY, Choi JH, Lee HJ, Kim NH, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi KM. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Baik+SH%5Bau%5D&dispmax=50

A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data | BMC Genomics |...A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data | BMC Genomics |...

Lewis JG, André CM: Effect of human alpha 2HS glycoprotein on mouse macrophage function. Immunology. 1980, 39 (3): 317-322. ... A glycoprotein that functions as extracellular chaperone that prevents aggregation of non-native proteins, which is involved in ... Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions [55]. ... types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma. 2002, Larchmont, NY, USA: Liebert ...
more infohttps://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-16-S1-S2
  • Three out of nine proteins identified to associate with HDL-4-Apo A-2 are involved in the regulation of fibrinolysis, namely, the plasmin regulator, alpha-2-antiplasmin, and two major components of the kallikrein-kinin pathway (coagulation factor XI and prekallikrein), and their physical presence in the HDL-4 subfraction was confirmed. (bmj.com)
  • The small HDL subclass rich in apolipoprotein A-2 content (HDL-4-Apo A-2) exhibited the most significant association with survival. (bmj.com)
  • In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns that characterize the large molars in Gigantopithecus 9 , 10 . (nature.com)
  • Its evolutionary relationships to other great ape species, and the divergence of these species during the Middle and Late Miocene epoch (16-5.3 million years ago), remain unclear 2 , 3 . (nature.com)
  • Full thermal age calculations can be found in Supplementary Data 2 . (nature.com)