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alpha-2-HS-Glycoproteinalpha-FetoproteinsBlood ProteinsLatexGlycoproteinsMolecular Sequence DataAmino Acid SequenceSequence Homology, Nucleic AcidTrypsinbeta 2-Glycoprotein IViral Envelope Proteinsalpha 1-AntitrypsinPlatelet Glycoprotein GPIb-IX ComplexGlycopeptidesOrosomucoidMembrane GlycoproteinsBase SequenceMyelin-Associated GlycoproteinReceptors, Adrenergic, alphaGlycosylationPlatelet Membrane GlycoproteinsAntibodies, MonoclonalCell LinePlatelet Glycoprotein GPIIb-IIIa ComplexHypoxia-Inducible Factor 1, alpha SubunitEncyclopedias as TopicChoroid PlexusProprotein ConvertasesCerebrospinal FluidEnzyme-Linked Immunosorbent AssayReagent Kits, DiagnosticDiabetes MellitusDiabetes Mellitus, Type 2Cinnamomum zeylanicumDiabetes Mellitus, Type 1Diabetes ComplicationsDiabetes Mellitus, ExperimentalGlycosidesPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsBiological Science DisciplinesArtificial IntelligenceProteomicsSupport Vector MachinesAlgorithmsPattern Recognition, AutomatedComputational BiologyGenomics
alpha-2-HS-Glycoprotein: A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Latex: A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.beta 2-Glycoprotein I: A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Platelet Glycoprotein GPIb-IX Complex: Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.OrosomucoidMembrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Myelin-Associated Glycoprotein: A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.Receptors, Adrenergic, alpha: One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Platelet Glycoprotein GPIIb-IIIa Complex: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.Hypoxia-Inducible Factor 1, alpha Subunit: Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Choroid Plexus: A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.Proprotein Convertases: Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Cinnamomum zeylanicum: The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Diabetes Complications: Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Artificial Intelligence: Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.Proteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Support Vector Machines: Learning algorithms which are a set of related supervised computer learning methods that analyze data and recognize patterns, and used for classification and regression analysis.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Pattern Recognition, Automated: In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.

Positive and negative elements modulate the promoter of the human liver-specific alpha2-HS-glycoprotein gene. (1/175)

The human alpha2-HS-glycoprotein (AHSG) and the 63-kDa rat phosphoprotein (pp63) are homologous plasma proteins that belong to the fetuin family. AHSG and pp63 are involved in important functions such as inhibition of insulin receptor tyrosine kinase activity, inhibition of protease activities, and regulation of calcium metabolism and osteogenesis. Studies of the AHSG proximal promoter performed in vitro in rat and human cells indicate that several NF-1 and C/EBP binding sites exert a positive effect on its transcriptional activity. However, until now, no distal elements have been examined in this gene, in either species. We report that the human AHSG gene promoter acts in a liver-specific manner and is further controlled by three distal, 5'-flanking elements. The negative elements III and I are, respectively, located 5' and 3' of the positive element II. All three elements require the natural context of the human AHSG gene to fully exert their negative or positive effect. Element I harbours a single binding site for NF-1. This nuclear factor thus appears to be able to up- or downregulate the AHSG gene depending on the site it binds to. Elements I, II and possibly III are absent in the rodent Ahsg gene encoding pp63.  (+info)

Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. (2/175)

A fraction of alpha2-Heremans-Schmid (alpha2-HS) glycoprotein (human fetuin) isolated from plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide fragment sequencing after tryptic digestion. Serine-312-containing peptides were phosphorylated to 77% as determined from relative peak heights in the mass spectrum, which together with the phosphorylation of serine-120 implies a molar degree of phosphorylation of at least 1. Approximately 20% of the circulating fetuin plasma pool was phosphorylated to approx. 1 mol of phosphate/mol of protein. The remainder did not contain phosphate, resulting in an average phosphorylation degree for the protein in plasma of approx. 0.2 mol/mol. The isolated alpha2-HS glycoprotein was a heterodimer in which the entire C-terminal part of the connecting peptide including threonine-321 was present, but traces of C-terminally trimmed connecting peptide fragments were also found. The short B-chain was O-glycosylated to approx. 40%, whereas the N-glycosylation of asparagine-138 and asparagine-158 seemed to be 100%. This finding, for the first time, that circulating human plasma fetuin is partly phosphorylated, implies that the effects of phosphorylated alpha2-HS glycoprotein on insulin signal transduction seen in different cell systems could be relevant to its physiological function in vivo.  (+info)

Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human alpha2-HS glycoprotein. (3/175)

Fetuin/alpha2-HS glycoprotein (alpha2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb Bgl II fragment contained exons 2, 3 and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of (T,C)n*(A,G)n. We have mapped mouse Ahsg at 16 cM adjacent to the Diacylglycerol kinase 3 (Dagk3) gene on chromosome 16 by genotyping interspecific backcross panels between C57BL/6J and Mus spretus. The position is syntenic with human chromosome 3q27, where the human AHSG gene resides. Using recombinant mouse alpha2-HSG expressed from a recombinant baculovirus, we demonstrate that mouse alpha2-HSG inhibits insulin-stimulated IR autophosphorylation and IR-TKA in vitro. In addition, mouse alpha2-HSG (25 microg/ml) completely abolishes insulin-induced DNA synthesis in H-35 rat hepatoma cells. Based on the sequence data and functional analysis, we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.  (+info)

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. (4/175)

Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein alpha2-HS-glycoprotein/fetuin (ASHG) binds to TGF-beta/BMP cytokines and blocks TGF-beta1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg(-/-) mice appeared normal at birth, but abnormalities were observed in adult Ahsg(-/-) mice. Maturation of growth plate chondrocytes was impaired, and femurs lengthened more slowly between 3 and 18 months of age in Ahsg(-/-) mice. However, bone formation was increased in Ahsg(-/-) mice as indicated by greater cortical thickness, accelerated trabecular bone remodeling, and increased osteoblast numbers on bone surfaces. The normal age-related increase in cortical thickness and bone mineral density was accelerated in Ahsg(-/-) mice and was associated with increased energy required to fracture. Bone formation in response to implanted BMP cytokine extended further from the implant in Ahsg(-/-) compared with Ahsg(+/+) mice, confirming the interaction between ASHG and TGF-beta/BMP cytokines in vivo. Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.  (+info)

Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. (5/175)

Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the metabolic syndrome. Here, we explore insulin signaling, glucose homeostasis, and the effect of a high-fat diet on weight gain, body fat composition, and glucose disposal in mice carrying two null alleles for the gene encoding fetuin, Ahsg (B6, 129-Ahsg(tm1Mbl)). Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle. Glucose and insulin tolerance tests in fetuin KO mice indicate significantly enhanced glucose clearance and insulin sensitivity. Fetuin KO mice subjected to euglycemic-hyperinsulinemic clamp show augmented sensitivity to insulin, evidenced by increased glucose infusion rate (P = 0.077) and significantly increased skeletal muscle glycogen content (P < 0.05). When fed a high-fat diet, fetuin KO mice are resistant to weight gain, demonstrate significantly decreased body fat, and remain insulin sensitive. These data suggest that fetuin may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.  (+info)

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. (6/175)

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.  (+info)

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. (7/175)

Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification. Using electron microscopy and dynamic light scattering, we demonstrate that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate. These "calciprotein particles" of 30-150 nm in diameter are initially amorphous and soluble but turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion. Solubilization in Ahsg-containing calciprotein particles provides a novel conceptual framework to explain how insoluble calcium precipitates may be transported and removed in the bodies of mammals. Mutational analysis showed that the basic calcium phosphate precipitation inhibition activity resides in the amino-terminal cystatin-like domain D1 of Ahsg. A structure-function analysis of wild type and mutant forms of cystatin-like domains from Ahsg, full-length fetuin-B, histidine-rich glycoprotein, and kininogen demonstrated that Ahsg domain D1 is most efficient in inhibiting basic calcium phosphate precipitation. The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition.  (+info)

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. (8/175)

Ectopic calcification is a frequent complication of many degenerative diseases. Here we identify the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level. Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D-rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background. This phenotype is not associated with apparent changes in calcium and phosphate homeostasis, but with a decreased inhibitory activity of the Ahsg-deficient extracellular fluid on mineral formation. The same underlying principle may contribute to many calcifying disorders including calciphylaxis, a syndrome of severe systemic calcification in patients with chronic renal failure. Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases.  (+info)

Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome | BMC...Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome | BMC...
Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearmans correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p | 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S.
Diabetic foot ulcers and serum fetuin-A levelsDiabetic foot ulcers and serum fetuin-A levels
The association between the development of diabetic foot and serum fetuin-A levels. Ozenç S, Simsek K, Yildirim A, Arslan E, Sari S, Ince M, Sarı O, Yeşilkaya S, Aydoğan U, Yaman H, Koç B, Sağlam K. Pol Arch Med Wewn. […]
Alpha-2-HS-glycoprotein - WikipediaAlpha-2-HS-glycoprotein - Wikipedia
alpha-2-HS-glycoprotein (AHSG) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in fetal than adult blood. Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. The choroid plexus is an established extrahepatic expression site. The mature circulating AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a ...
Abstract MP88: Fetuin-A, a Vascular Biomarker of Cognitive Decline in Older Adults | CirculationAbstract MP88: Fetuin-A, a Vascular Biomarker of Cognitive Decline in Older Adults | Circulation
Objectives: The contribution of vascular disease to neurocognitive decline is now widely recognized. Fetuin-A is an abundant plasma protein known to predict vascular disease. Prior studies have shown that fetuin-A levels are lower in patients with Alzheimers disease in direct proportion to the severity of cognitive impairment; however, their association with normal cognitive aging is unknown. We evaluated the association of serum fetuin-A levels with cognitive function in relatively high-functioning, community-dwelling older adults from the Rancho Bernardo Study.. Methods: This is a population-based study of 1382 older adults (median age 75) who had plasma fetuin-A levels and cognitive function evaluated in 1992-96; 855 had repeat cognitive function assessment a median of 4 years later.. Results: Adjusting for age, sex, education, and depression, higher levels of fetuin-A were associated with better baseline performance on the Mini-Mental Status Exam (MMSE) (P=0.012) and a tendency for better ...
Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in...Phosphorylated fetuin-A-containing calciprotein particles are associated with aortic stiffness and a procalcific milieu in...
Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high incidence of vascular morbidity and mortality in this population. A network of inhibitors work in concert to reduce mineralization risk in extra-osseous tissue. Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts with mineral ions to form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought to assess whether CPP fetuin-A levels were associated with procalcific factors and aortic stiffness in a cohort of patients with Stages 3 and 4 CKD.. ...
FSI - Fetuin-A and Change in Body Composition in Older PersonsFSI - Fetuin-A and Change in Body Composition in Older Persons
Context: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown. Objective: To determine the association of fetuin-A levels with changes in body composition over 5 yr. Study Design: Observational cohort study nested in the Health Aging and Body Composition Study.
Plasma Fetuin-a concentration, genetic variation in the AHSG gene and risk of colorectal cancer - Cancer Epidemiology Unit (CEU)Plasma Fetuin-a concentration, genetic variation in the AHSG gene and risk of colorectal cancer - Cancer Epidemiology Unit (CEU)
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Ιατρικά Άρθρα Αλέξανδρος Γ. Σφακιανάκης: The association between circulating fetuin-A levels and type 2 diabetes mellitus risk:...Ιατρικά Άρθρα Αλέξανδρος Γ. Σφακιανάκης: The association between circulating fetuin-A levels and type 2 diabetes mellitus risk:...
A total of 32 studies including 27 case-control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges g = 1.73, 95% CI (1.25-2.22), P , 0.001], with significant heterogeneity across studies (P , 0.001, I 2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26-2.08), P , 0.001], with no significant heterogeneity (P = 0.10, I 2 = 46.06%).. ...
Haplotype analysis of the human α2-HS glycoprotein (fetuin) gene | Annals of Human Genetics | Cambridge CoreHaplotype analysis of the human α2-HS glycoprotein (fetuin) gene | Annals of Human Genetics | Cambridge Core
Haplotype analysis of the human α2-HS glycoprotein (fetuin) gene - Volume 65 Issue 1 - M. OSAWA, I. YUASA, T. KITANO, J. HENKE, M. KANEKO, T. UDONO, N SAITOU, K. UMETSU
α2-HS-Glycoprotein ( A2HS): Improved Phenotyping by Focusing in an Immobilized pH-Gradient. Allele Frequencies in a South...α2-HS-Glycoprotein ( A2HS): Improved Phenotyping by Focusing in an Immobilized pH-Gradient. Allele Frequencies in a South...
The use of A2HS as an additional polymorphic marker in paternity testing and related forensic applications is not yet introduced in the routine expertises of all laboratories. One of several causes...
Incident diabetes mellitus may explain the association between sleep duration and incident coronary heart diseaseIncident diabetes mellitus may explain the association between sleep duration and incident coronary heart disease
article{f963b6fc-e756-4df4-ac43-a0f6062f09ae, abstract = {,p,Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that any association with sleep duration would not hold for cases of incident CHD occurring before incident diabetes (non-diabetes CHD) but would hold true for cases of incident CHD following incident diabetes (diabetes-CHD). Methods: A total of 6966 men and 9378 women aged 45-73 years from the Malmö Diet Cancer Study, a population-based, prospective cohort, who had answered questions on habitual sleep duration and did not have a history of prevalent diabetes or CHD were included in the analyses. Incident cases of diabetes and CHD were ...
Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two...Circulating Biomarkers of Dairy Fat and Risk of Incident Diabetes Mellitus Among Men and Women in the United States in Two...
In 2 separate cohorts of US men and women, 3 plasma biomarkers of dairy fat, 15:0, 17:0, and trans-16:1n-7, were associated with lower risk of incident diabetes mellitus. Findings were generally similar for erythrocyte fatty acids, although with smaller and not always significant magnitudes of association. These results provide new evidence on associations of dairy-derived circulating fatty acids and risk of diabetes mellitus.. Our findings suggest that either these dairy fatty acids themselves or other correlated factors in dairy fat could reduce the risk of diabetes mellitus. For instance, short- and medium-chain saturated fats, vitamin D (a fat-soluble vitamin), omega-3 fats, or gangliosides in dairy fat could each play a role.27 The magnitudes of our associations, linear dose response, independence from established diabetes risk factors and other dietary habits, and consistency of findings across sensitivity analyses argue against residual confounding as the sole explanation for our ...
PRIME PubMed | Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3...PRIME PubMed | Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3...
PubMed journal article Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Relationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for Atherosclerosis | Science PublicationsRelationship between Fetuin-A and Systemic Lupus Erythematosus as a Predictor Marker for Atherosclerosis | Science Publications
Problem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were taken from 100 female SLE patients. All Patient samples were analyzed by ELISA for determination of Fetuin-A level. Calcium, Phosphate, C3 compelement, Lipid profile, Creatinine and urea were measured also in SLE patients compared with healthy control volunteers. Results: We found that Serum fetuin-A had been positively associated with carotid arterial stiffness, independent of known atherogenic factors in healthy subjects. Furthermore, Fetuin-A was correlated negatively with IMT, SLEDAI, CRI, CaxP product, Triglycerdies, VLDL and LDL. While it was
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Results Serum FGF-23 and fetuin-A levels were significantly increased in the CAD patients as compared with the non-CAD patients (26.7 [interquartile range, 22.4-31.9] vs 15.7 [interquartile range, 13.2-18.1] pg/mL and 904.7 [interquartile range, 695.5-1021.6] vs 469.6 [331.4-660.5] mg/L, respectively; P , 0.001 for both). Furthermore, a positive correlation was identified between FGF-23 and fetuin-A levels and the total number of plaques (r = 0.21 and r = 0.28, respectively; P , 0.001 for both). In multivariate logistic regression analysis, age, smoking status, uric acid, FGF-23, and fetuin-A levels were found to be independently associated with the presence of CAD. ...
Fetuin-A and incident diabetes mellitus in older personsFetuin-A and incident diabetes mellitus in older persons
Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance.
Scientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient CodeScientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient Code
Hypotheses regarding the relationships between Gigantopithecus and extinct and extant hominids are wide ranging but difficult to substantiate because of its highly derived dentognathic morphology, the absence of cranial and post-cranial remains and the lack of independent molecular validation.. We retrieved dental enamel proteome sequences from a 1.9-million-year-old G. blacki molar found in Chuifeng Cave, China. The thermal age of these protein sequences is approximately five times greater than that of any previously published mammalian proteome or genome. We demonstrate that Gigantopithecus is a sister clade to orangutans (genus Pongo) with a common ancestor about 12-10 million years ago, implying that the divergence of Gigantopithecus from Pongo forms part of the Miocene radiation of great apes.. In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns ...
KAKEN - Researchers | TAKEDA Hajime (80294792)KAKEN - Researchers | TAKEDA Hajime (80294792)
Affiliation：愛媛大学,医学部・附属病院,講師, Research Field：Urology, Keywords：尿路結石症,プロトロンビンF1,結晶形成抑制,結石溶解,Alpha 2-HS-glycoprotein,プロトロビンF1,プロトロンビン,Prothrombin,チオバチルスチオオキシダンス,dissolution of stone, # of Research Projects：2, # of Research Products：0
AHSG elisa kit product blogAHSG elisa kit product blog
Blog on AHSG elisa kit product: The Human AHSG ahsg (Catalog #MBS701816) is an ELISA Kit and is intended for research purposes only. The ...
Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)
Abcams Alpha 2 HS Glycoprotein ELISA Kit suitable for Cell culture supernatant, Milk, Urine, Serum, Plasma, Cerebral Spinal Fluid in human. Reliably quantify…
Genetic mapping and functional studies of a natural inhibitor of the insulin receptor . . . by Vivian J. Cintron"Genetic mapping and functional studies of a natural inhibitor of the insulin receptor . . ." by Vivian J. Cintron
Fetuin/α2-HS glycoprotein (α2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb BgI II fragment contained exons 2, 3, and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of
C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort...C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort...
Low-grade systemic inflammation is associated with an increased risk of type 2 diabetes mellitus in middle-aged men. Inflammation could be one mechanism by which known risk factors for diabetes mellitus, such as obesity, smoking, and hypertension, promote the development of diabetes mellitus.
Frode Norheim - Institute of Basic Medical SciencesFrode Norheim - Institute of Basic Medical Sciences
Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Holen, Torgeir; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5) . doi: 10.14814/phy2.13183 Show summary The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well documented if some of the beneficial effects of exercise can be explained by altered secretion of hepatokines. The aim of this study was to examine the effect of interaction between fetuin‐A and FFAs on insulin sensitivity after ...
Browse by Journal : Sussex Research OnlineBrowse by Journal : Sussex Research Online
Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Weaving, Gary, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2011) Instability of fibroblast growth factor-23 (FGF-23): implications for clinical studies. Clinica Chimica Acta, 412 (11-12). pp. 1008-1011. ISSN 1873-3492 Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Poor agreement between commercial ELISAs for plasma fetuin-A: an effect of protein glycosylation? Clinica Chimica Acta, 411 (17-18). pp. 1367-1370. ISSN 0009-8981 Shams, Sedigheh, Shafi, Shahida, Bodman-Smith, Kikki, Williams, Peter, Mehta, Sweta and Ferns, Gordon A (2008) Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clinica Chimica Acta, 395 (1-2). pp. 42-46. ISSN 0009-8981 ...
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In this study, we demonstrated that patients with type 2 diabetes who additionally suffer from PAD have significantly higher fetuin-A levels than patients with diabetes but without any atherosclerotic burden.. Our data are in opposition to the results from Eraso et al. (14), who assumed that patients with type 2 diabetes and PAD have lower plasma concentrations of fetuin-A than patients with type 2 diabetes alone. In the latter study, 738 patients with type 2 diabetes but without clinical evidence of cardiovascular disease were enrolled. From these study participants, only 5.1% (n = 38) had PAD, defined by an ABI ,0.9. Although PAD patients show the highest co-burden of manifestations of atherosclerosis (15), which is even higher in patients with PAD and type 2 diabetes (1-3,15), the 38 patients in the latter article did not show any other manifestation of atherosclerosis and must thus be regarded as highly selected and not representative (20).. In contrast to Eraso et al. (14), a decrease of ...
GeneDxGeneDx
AAAS, AARS, AARS2, AASS, ABAT, ABCA5, ABCA7, ABCB7, ABCC8, ABCC9, ABCD1, ABCD3, ACAD9, ACADM, ACADS, ACADSB, ACMSD, ACO2, ACOT7, ACOX1, ACSF3, ACSL4, ACTB, ACTG1, ACTL6B, ACVR1, ACVRL1, ACY1, ADAM22, ADAR, ADAT3, ADCK3, ADCK4, ADD3, ADGRG1, ADK, ADNP, ADRA2B, ADSL, AFF2, AFG3L2, AGA, AGGF1, AGK, AGTR2, AHI1, AHSG, AIFM1, AIMP1, AIMP2, AKT1, AKT2, AKT3, ALAD, ALDH18A1, ALDH1B1, ALDH3A2, ALDH4A1, ALDH5A1, ALDH7A1, ALDOB, ALG1, ALG11, ALG12, ALG13, ALG2, ALG3, ALG6, ALG8, ALG9, ALMS1, ALPL, ALX4, AMACR, AMER1, AMPD2, AMT, ANK2, ANK3, ANKH, ANKLE2, ANKRD11, ANO10, ANO3, AP1S2, AP3B2, AP3D1, AP4B1, AP4E1, AP4M1, AP4S1, APC2, APOA1BP, APOPT1, APTX, AQP2, ARCN1, ARFGEF2, ARG1, ARHGAP31, ARHGEF15, ARHGEF6, ARHGEF9, ARID1A, ARID1B, ARID2, ARL13B, ARMC9, ARNT2, ARSA, ARV1, ARVCF, ARX, ASAH1, ASCL1, ASL, ASNS, ASPA, ASPM, ASS1, ASTN1, ASTN2, ASXL1, ASXL2, ASXL3, ATAD1, ATAD3A, ATIC, ATN1, ATP13A2, ATP1A2, ATP1A3, ATP2A2, ATP2B3, ATP5A1, ATP5E, ATP6AP1, ATP6AP2, ATP6V0A2, ATP6V0C, ATP6V1A, ATP6V1B2, ATP7A, ...
House Bill 1157 (2018) - The Florida SenateHouse Bill 1157 (2018) - The Florida Senate
The page numbers, when listed, for citations are constantly under review. The journals or printed bills of the respective chambers should be consulted as the official documents of the Legislature. The links for the page numbers are formatted to open the bill text PDF directly to the page containing the citation. However, if your browser is set to open PDFs in a new window, as is often the case with 64-bit browsers, the bill text will open to the first page. ...
Alpha-2HS glycoprotein | definition of alpha-2HS glycoprotein by Medical dictionaryAlpha-2HS glycoprotein | definition of alpha-2HS glycoprotein by Medical dictionary
Looking for online definition of alpha-2HS glycoprotein in the Medical Dictionary? alpha-2HS glycoprotein explanation free. What is alpha-2HS glycoprotein? Meaning of alpha-2HS glycoprotein medical term. What does alpha-2HS glycoprotein mean?
Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial |...Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial |...
In this 8-week randomized trial of overweight men and women, adiponectin and IL-6 levels increased for the caffeinated coffee group as compared with the group receiving no coffee. Fetuin-A levels decreased for decaffeinated coffee as compared with no coffee at the end of the intervention. There were no significant differences between the three treatment groups for CRP or measures of glucose metabolism.. Our results for adiponectin are consistent with one observational study and non-randomized trial that found higher adiponectin concentrations with increasing coffee consumption [8, 10]. The effects of coffee on fetuin-A concentrations in our trial are consistent with the beneficial effects of coffee on liver function suggested by cross-sectional studies of coffee consumption and liver enzymes [9]. The lack of significant effects of coffee consumption on glucose tolerance may seem inconsistent with the effect of coffee consumption on adiponectin levels and the association between increases in ...
mediaTUM - Media and Publication ServermediaTUM - Media and Publication Server
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System | Arteriosclerosis, Thrombosis, and...Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System | Arteriosclerosis, Thrombosis, and...
Approach and Results-Immunohistochemistry and quantitative polymerase chain reaction showed that GRP expression and accumulation are upregulated with calcification simultaneously with osteocalcin and matrix Gla protein (MGP). Using conformation-specific antibodies, both γ-carboxylated GRP and undercarboxylated GRP species were found accumulated at the sites of mineral deposits, whereas undercarboxylated GRP was predominant in calcified aortic valve disease valvular interstitial cells. Mineral-bound GRP, MGP, and fetuin-A were identified by mass spectrometry. Using an ex vivo model of vascular calcification, γ-carboxylated GRP but not undercarboxylated GRP was shown to inhibit calcification and osteochondrogenic differentiation through α-smooth muscle actin upregulation and osteopontin downregulation. Immunoprecipitation assays showed that GRP is part of an MGP-fetuin-A complex at the sites of valvular calcification. Moreover, extracellular vesicles released from normal vascular smooth muscle ...
alpha2HS Glycoprotein - Medical Dictionary online-medical-dictionary.orgalpha2HS Glycoprotein - Medical Dictionary online-medical-dictionary.org
A Fetuin subtype that is synthesized by Hepatocytes and secreted into the circulation. It plays a major Role in preventing Calcium precipitation in the Blood ...
Medical Abbreviations - AHSGMedical Abbreviations - AHSG
Kaufmann-Peterson [base]; Keratitic Precipitate; Keratitis Punctata; Kidney Protein; Killed Parenteral [vaccine]; Klebsiella ...
Can dietary omega-3 fatty acids modulate fetuin-a protein?<...Can dietary omega-3 fatty acids modulate fetuin-a protein?<...
TY - JOUR. T1 - Can dietary omega-3 fatty acids modulate fetuin-a protein?. AU - Singh, R. B.. AU - DeMeester, Fabien. AU - Pella, Daniel. AU - Basu, Tapan K.. AU - Watson, Ronald R. PY - 2011. Y1 - 2011. UR - http://www.scopus.com/inward/record.url?scp=79961162330&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79961162330&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:79961162330. VL - 4. SP - 175. EP - 176. JO - World Heart Journal. JF - World Heart Journal. SN - 1556-4002. IS - 3. ER - ...
Betty HeremansBetty Heremans
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Your Greatest Hits in the Mix - 8 & 9 januari 2016 - JoeYour Greatest Hits in the Mix - 8 & 9 januari 2016 - Joe
Strek die benen en gooi je armen in de lucht, huis-dj Patrick Heremans gooit ook in het nieuwe jaar weer You Greatest Hits in the Mix! Met vanavond hits van onder andere The Village People, Clouseau, 10CC, Michael Jackson en Taylor Swift. Zaterdagavond neemt Patrick de grootste hits van onder andere Snap, Sydney Youngbloodn The Human League en Pat Benetar onder handen. Muziek vrijdag 08/01/2016: The Village People - YMCAMighty Dub Katz - Magic Carpet RideThe Sugababes - Round RoundDead Or Alive - You Spin Me Round (Like A Record)Christina Aguilera - Aint No Other Man The Blow Monkeys - It Doesnt Have To Be This WayGeorge Michael - MonkeyThe Simple Minds - Someone, Somewhere In SummertimeSuzanne Vega & DNA - Toms DinerStevie Wonder - Living For The City Clouseau - Zin Om Te BewegenTaylor Swift - Shake It OffDöf - CodoPeter Schilling - Major TomPhil Collins - Billie Dont Lose My Number 10CC - Dreadlock HolidayDuran Duran - NotoriousJOE Public - Live And LearnBlondie + Doors - Rapture + Riders On
Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in...Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in...
TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
Evaluation of the Pleiotropic Effects of StatinsHighlights | Arteriosclerosis, Thrombosis, and Vascular BiologyEvaluation of the Pleiotropic Effects of StatinsHighlights | Arteriosclerosis, Thrombosis, and Vascular Biology
Approach and Results-We adapted Egger regression, a technique frequently used in Mendelian randomization studies to detect genetic pleiotropy, to reanalyze the available randomized control trial data of statin therapy. For cardiovascular end points, each 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 0.77 (95% confidence interval, 0.71-0.84) with an intercept that was indistinguishable from zero (intercept, −0.0032; [95% confidence interval, −0.090 to 0.084]; P=0.94), indicating no pleiotropy. For incident diabetes mellitus, a 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 1.07 (95% confidence interval, 0.99-1.16) and an intercept nondistinguishable from zero (intercept, −0.015; [95% confidence interval, −0.30 to 0.27]; P=0.91), again indicating no pleiotropy. ...
Nutrients | Free Full-Text | High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of...Nutrients | Free Full-Text | High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of...
Cardiovascular calcification is prevalent in the aging population and in patients with chronic kidney disease (CKD) and diabetes mellitus, giving rise to substantial morbidity and mortality. Vitamin K-dependent matrix Gla-protein (MGP) is an important inhibitor of calcification. The aim of this study was to evaluate the impact of high-dose menaquinone-7 (MK-7) supplementation (100 µg/g diet) on the development of extraosseous calcification in a murine model. Calcification was induced by 5/6 nephrectomy combined with high phosphate diet in rats. Sham operated animals served as controls. Animals received high or low MK-7 diets for 12 weeks. We assessed vital parameters, serum chemistry, creatinine clearance, and cardiac function. CKD provoked increased aortic (1.3 fold; p < 0.05) and myocardial (2.4 fold; p < 0.05) calcification in line with increased alkaline phosphatase levels (2.2 fold; p < 0.01). MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline
Cerebrospinal fluid fetuin-A is a biomarker of active multiple sclerosis. | Multiple Sclerosis Discovery ForumCerebrospinal fluid fetuin-A is a biomarker of active multiple sclerosis. | Multiple Sclerosis Discovery Forum
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Rancho Bernardo Yoga San Diego - Our TeachersRancho Bernardo Yoga San Diego - Our Teachers
Rancho Bernardo Yoga teachers include Jeanne Stone, Lori Cota, Sarah Gutz, Erin VandenBergh, Mary Beth Schrepferman, Becky MacBain, and Debra Logan
How to Reward Yourself (Aside from Food) | Fitness Together - Rancho BernardoHow to Reward Yourself (Aside from Food) | Fitness Together - Rancho Bernardo
When was the last time you did something to reward yourself? If you cant remember, then it may be time to change that. It is very beneficial to set short-term goals.
Carpool Applegate 95703 to Rancho Cordova (CA) California Rideshare AppCarpool Applegate 95703 to Rancho Cordova (CA) California Rideshare App
... Find your perfect carpool to work or for any trip. FREE. Start a website for your group!
Wrecked 1999 CHRYSLER SEBRING LX for sale in CA - RANCHO CUCAMONGA, Lot 17349815Wrecked 1999 CHRYSLER SEBRING LX for sale in CA - RANCHO CUCAMONGA, Lot 17349815
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A Comparison of the effects of fixed dose Valsartan/Hydrochlorothiazide and Atenolol/Chlorthalidone on Blood Lipid Profile in...A Comparison of the effects of fixed dose Valsartan/Hydrochlorothiazide and Atenolol/Chlorthalidone on Blood Lipid Profile in...
Ahaneku G.I., Osuji C.U., Anisiuba B.C., Ikeh V.O., Oguejiofor O.C. and Ahaneku J.E., (2011). Evaluation of blood pressure and indices of obesity in a typical rural community in eastern Nigeria. Ann. Afr. Med. 10 (2): 120-6.. Allain C.C., Poon L.S., Chain C.S.G., Richmond W,. and Fu P.C., (1974). Enzymatic etermination of the serum cholesterol. Clin. Chem. 20(4): 470-475.. Barham D. and Trinder P., (1972). Clinical guide to laboratory test. Analyst 97: 142.. Barzilay J.I., Davis B.R., Cutler J.A., Pressel S.L., Whelton P.K., Basile J., Margolis KL., Ong S.T., Sadler L.S. and Summerson J., (2006). Fasting glucose levels and incident diabetes mellitus in older non-diabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT). Ach. Intern. Med. 166(20): 2191-2201.. Benson S.C., Pershadsingh H.A., Chittiboyina A., Desai P., Pravenec M., Qi N., Wang J., Avery M.A. and ...
Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress...Exendin-4 Inhibits the Expression of SEPP1 and Fetuin-A via Improvement of Palmitic Acid-Induced Endoplasmic Reticulum Stress...
ER stress plays a crucial role in obesity, insulin resistance [27], and NAFLD [28]. The ER stress response is triggered by different stimuli such as oxidative stress, hypoxia, enhanced protein synthesis, high levels of glucose and saturated fatty acids, and high levels of ER stress inducers, such as thapsigargin and Tuni [29,30]. The ER stress response also stimulates ER stress sensors such as ATF6, phosphorylation of PERK and IRE-1α [31], and ER stress-induced transcription factors, such as CHOP and XBP-1 [32,33]. In a previous study, we demonstrated that exendin-4 has a protective effect against PA-induced ER stress in hepatocytes [34]. In cells treated with PA, changes in the expression of the ER stress markers, SEPP1 and fetuin-A showed similar patterns, and exendin-4 treatment in cells pretreated with PA or Tuni significantly reduced the expression of these genes. In addition, relieving ER stress by exendin-4 induced decreased expression of the SEPP1 and fetuin-A genes. Thus, these results ...
Arterial Stiffness in the Heart Disease of CKD | American Society of NephrologyArterial Stiffness in the Heart Disease of CKD | American Society of Nephrology
Under normal conditions, several calcification inhibitors, including pyrophosphate, adenosine, matrix Gla protein, osteopontin, fetuin-A, osteoprotegerin, and bone morphogenetic protein-7, protect against abnormal mineral deposition in the vessel wall, whereas hypercalcemia, increased levels of parathyroid hormone, inflammatory cytokines, oxidative stress, uremic toxins, advanced glycation end-products, and, most importantly, phosphates induce vascular calcification. During CKD there is an imbalance between inhibitors and inducers of vascular calcification.24 Phosphates increase during CKD because of progressively reduced renal excretion. High phosphate levels may directly induce vascular calcification via the activation of Toll-like receptor 4/NF-κ light-chain enhancer of activated B cells (NF-κB) signaling in VSMCs.25 Moreover, in the presence of high phosphate levels, VSMCs can change their phenotype into osteoblast-like cells via the loss of smooth muscle markers (e.g., α-smooth muscle ...
Calcific Uremic Arteriolopathy Calciphylaxis David Shure. - ppt downloadCalcific Uremic Arteriolopathy 'Calciphylaxis' David Shure. - ppt download
Calciphylaxis CUA Calciphylaxis Metastatic systemic calcifications after invasive manipulation of animal model No vascular calcifications found CUA Occurs in presence of uremia Abnormalities in divalent ion ie PTH, Ca, PO4 (not required) Vascular calcifications at site of lesions
Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months...Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals a high prevalence of erosions at four months...
The gold standard for joint damage in RA is currently the presence of radiological erosions. Management decisions including when to institute aggressive treatment with drugs such as methotrexate and combination regimens are influenced by the presence or absence of erosive change. However, most patients at diagnosis do not have erosions on plain radiography.1 25 There is often a delay of 6 to 12 months before erosions can be confirmed by radiography and during this time the clinician must treat empirically according to clinical indicators of synovitis, which may not accurately predict prognosis.4 26 MRI can reveal erosions as well as synovitis and tendonitis early in RA, giving a detailed picture of joint inflammation and damage.10 11 22 This study of 42 RA patients with recent onset disease (median symptom duration of four months) provides baseline information on MRI changes in the dominant wrist. This is the largest reported study of MRI at this early stage of RA.. We have developed a scoring ...
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The most recent Cochrane reviews highlight no benefit in terms of pain relief or physical function from arthroscopic washout or debridement for patients with osteoarthritis of the knee.3 4 Two meta-analyses also suggest no benefit,5 6 with the most recent noting that arthroscopy is not without hazard and that this should be considered in the light of poor efficacy.6 Arthroscopic menisectomy does, however, have a role in specific patients. A recent randomised study in patients with no signs of osteoarthritis on plain radiography but who had persisting medial joint line knee pain despite conservative management found that meniscal resection was beneficial.7 Current guidance from the National Institute for Health and Care Excellence (NICE) suggests that referral for arthroscopic lavage and debridement should not be offered unless the person has a clear history of mechanical locking.1 But in a poll on thebmj.com after the most recent meta-analysis was published, 70% of respondents thought … ...
Which radiographic findings are characteristic of Pott disease (tuberculous [TB] spondylitis)?Which radiographic findings are characteristic of Pott disease (tuberculous [TB] spondylitis)?
Radiographic changes associated with Pott disease present relatively late. The following are radiographic changes characteristic of spinal tuberculosis on plain radiography:{ref35} Lytic destruction ... more
Oral administration of pyrophosphate inhibits connective tissue calcification | EMBO Molecular MedicineOral administration of pyrophosphate inhibits connective tissue calcification | EMBO Molecular Medicine
Contrary to the general assumption, we found that PPi has bioavailability in humans and mice when administered orally (Fig 1). The observed transient elevation found in healthy volunteers (Fig 1A) indicates that in both GACI and in PXE patients, PPi levels may be transiently raised to the physiological level when 67 or 98 mg Na4PPi/kg of body weight is taken. Importantly, it has been shown that inhibition of calcification in uremic rats and in PXE mice can be achieved by daily intraperitoneal injections of PPi triggering transient increase in plasma PPi levels (ONeill et al, 2011; Pomozi et al, 2017). We determined a t1/2 = 44.7 min what is rather similar to that published in rat (34.1 min; ONeill et al, 2011).. We also demonstrated significant attenuation of calcification in two different well‐characterized mouse models of ectopic calcification disorders, PXE and GACI when the animals were treated with pyrophosphate orally. Furthermore, we demonstrated PPi uptake from the oral cavity and ...
Ectopic calcification as very well as fatty and fibrotic tissues accumulation - Aurora Kinases as Druggable Targets in Cancer...Ectopic calcification as very well as fatty and fibrotic tissues accumulation - Aurora Kinases as Druggable Targets in Cancer...
Ectopic calcification as very well as fatty and fibrotic tissues accumulation occurs in skeletal muscle during the disease development of Duchenne buff dystrophy (DMD), a degenerative muscle disorder caused by mutations in the dystrophin gene. the nmMSCs become turned on during the disease development in dKO rodents, exhibiting elevated growth and difference possibilities (adipogenesis, osteogenesis and fibrogenesis). We discovered that after co-culturing the dKO-nmMSCs with dKO-MPCs also, the myogenic difference potential of the dKO-MPCs was decreased. This impact was discovered to end up being possibly mediated by the release of secreted frizzled-related proteins 1 by the dKO-nmMSCs. We posit that the speedy incidence of fibrosis as a result, ectopic calcification and fats deposition, in dKO rodents, is certainly not really just attributable to the speedy exhaustion of the MPC pool, but is certainly also the effect of nmMSC account activation. Outcomes from this research recommend that methods ...
Omega ResearchOmega Research
BACKGROUND: In patients with dilated (idiopathic) cardiomyopathy (DCM), little is known about the presence of valvular calcification and its association with hypovitaminosis D, which may predispose affected tissues to calcification. Our objectives were 2-fold: to conduct a retrospective assessment of echocardiographic evidence of valvular calcification in patients with DCM who were known to have hypovitaminosis D (25(OH)D ...
Dr. Peter Schmid, OD | Streetsboro, OH | HealthgradesDr. Peter Schmid, OD | Streetsboro, OH | Healthgrades
Dr. Peter Schmid, OD is a Optometrist in Streetsboro, OH. He is accepting new patients. Be sure to call ahead with Dr. Schmid to book an appointment.
Items where Author is Schmid, Christoph D. - edocItems where Author is "Schmid, Christoph D." - edoc
Elkon, Ran and Milon, Beatrice and Morrison, Laura and Shah, Manan and Vijayakumar, Sarath and Racherla, Manoj and Leitch, Carmen C. and Silipino, Lorna and Hadi, Shadan and Weiss-Gayet, Michèle and Barras, Emmanuèle and Schmid, Christoph D. and Ait-Lounis, Aouatef and Barnes, Ashley and Song, Yang and Eisenman, David J. and Eliyahu, Efrat and Frolenkov, Gregory I. and Strome, Scott E. and Durand, Bénédicte and Zaghloul, Norann A. and Jones, Sherri M. and Reith, Walter and Hertzano, Ronna ...
Rancho, Rancho Suppliers and Manufacturers at Alibaba.comRancho, Rancho Suppliers and Manufacturers at Alibaba.com
Rancho, Wholesale Various High Quality Rancho Products from Global Rancho Suppliers and Rancho Factory,Importer,Exporter at Alibaba.com.
Word Processing in Rio Rancho, NM by shutdownWord Processing in Rio Rancho, NM by shutdown
Please Contact Us so we can correct the problem. Kindly copy and paste the "Error Details" that appear below into your message to us ...
FetuinFetuin
Multiple sclerosis drug pipelineMultiple sclerosis drug pipeline
Fetuin-BFetuin-B
ORM1ORM1
Alpha-2-HS-glycoproteinAlpha-2-HS-glycoprotein
CITED2CITED2
FSHBFSHB
Alpha-1-B glycoproteinAlpha-1-B glycoprotein
Alpha-galactosidaseAlpha-galactosidase
Lysosomal storage diseaseLysosomal storage disease
PLCB3PLCB3
HLA-DPB1HLA-DPB1
GRIN3AGRIN3A
Piet BorstPiet Borst
Integrin-linked kinaseIntegrin-linked kinase
Laminin, gamma 1Laminin, gamma 1
HLA-DRHLA-DR
HLA-DRAHLA-DRA
PLCG2PLCG2
Hepatocyte nuclear factor 4 alphaHepatocyte nuclear factor 4 alpha
IduronidaseIduronidase
CD8ACD8A
AfaminAfamin
ATPase, Na+/K+ transporting, alpha 1ATPase, Na+/K+ transporting, alpha 1
Apolipoprotein HApolipoprotein H
Bone sialoproteinBone sialoprotein
MSX1MSX1
AHSA1AHSA1
Beta-secretase 2Beta-secretase 2
Post-translational modificationPost-translational modification
Glycogen phosphorylaseGlycogen phosphorylase
Platelet-derived growth factorPlatelet-derived growth factor
Drotrecogin alfaDrotrecogin alfa
PeptidoglycanPeptidoglycan
ATP-binding cassette transporterATP-binding cassette transporter
LAG3LAG3
MucinMucin
ACE2, a enciclopedia libreACE2, a enciclopedia libre
Post-translational modificationPost-translational modification
Dipeptidyl peptidase-4Dipeptidyl peptidase-4
VirusVirus
ProteoglycanProteoglycan
Extracellular matrixExtracellular matrix
Interleukin 17Interleukin 17
OrosomucoidOrosomucoid
FERMT3FERMT3
GlycoproteinGlycoprotein
ABC proteini - Википедија, слободна енциклопедијаABC proteini - Википедија, слободна енциклопедија
DesminDesmin
4-1BB ligand4-1BB ligand
CD4CD4
CD44CD44
SarcoidosisSarcoidosis
PerlecanPerlecan
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
alpha-2-HS-Glycoproteinalpha-FetoproteinsBlood ProteinsLatexGlycoproteinsMolecular Sequence DataAmino Acid SequenceSequence Homology, Nucleic AcidTrypsinbeta 2-Glycoprotein IViral Envelope Proteinsalpha 1-AntitrypsinPlatelet Glycoprotein GPIb-IX ComplexGlycopeptidesOrosomucoidMembrane GlycoproteinsBase SequenceMyelin-Associated GlycoproteinReceptors, Adrenergic, alphaGlycosylationPlatelet Membrane GlycoproteinsAntibodies, MonoclonalCell LinePlatelet Glycoprotein GPIIb-IIIa ComplexHypoxia-Inducible Factor 1, alpha SubunitEncyclopedias as TopicChoroid PlexusProprotein ConvertasesCerebrospinal FluidEnzyme-Linked Immunosorbent AssayReagent Kits, DiagnosticDiabetes MellitusDiabetes Mellitus, Type 2Cinnamomum zeylanicumDiabetes Mellitus, Type 1Diabetes ComplicationsDiabetes Mellitus, ExperimentalGlycosidesPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsBiological Science DisciplinesArtificial IntelligenceProteomicsSupport Vector MachinesAlgorithmsPattern Recognition, AutomatedComputational BiologyGenomics
Alpha-2-HS-glycoprotein - WikipediaAlpha-2-HS-glycoprotein - Wikipedia
Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)Human Alpha 2 HS Glycoprotein ELISA Kit (ab108855)
Genetic mapping and functional studies of a natural inhibitor of the insulin receptor . . . by Vivian J. Cintron"Genetic mapping and functional studies of a natural inhibitor of the insulin receptor . . ." by Vivian J. Cintron
Fetuin-A and incident diabetes mellitus in older personsFetuin-A and incident diabetes mellitus in older persons
KAKEN - Researchers | TAKEDA Hajime (80294792)KAKEN - Researchers | TAKEDA Hajime (80294792)
Scientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient CodeScientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient Code
antibodies-Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum-Genemed Synthesis Inc.antibodies-Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum-Genemed Synthesis Inc.
Primary Antibodies-Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG-Alpha Diagnostic International Inc.Primary Antibodies-Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG-Alpha Diagnostic International Inc.
alpha-2-HS-Glycoprotein | Profiles RNSalpha-2-HS-Glycoprotein | Profiles RNS
alpha-2-HS-glycoprotein 2 - Creative Biogenealpha-2-HS-glycoprotein 2 - Creative Biogene
Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit - ELISA GenieBovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit - ELISA Genie
Rat Ahsg(Alpha-2-HS-glycoprotein) ELISA Kit - Xpress Biotech InternationalRat Ahsg(Alpha-2-HS-glycoprotein) ELISA Kit - Xpress Biotech International
AHSG Gene - GeneCards | FETUA Protein | FETUA AntibodyAHSG Gene - GeneCards | FETUA Protein | FETUA Antibody
Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...
Diabetes Mellitus: Type 2 | GreenMedInfo | Disease | Natural MedicineDiabetes Mellitus: Type 2 | GreenMedInfo | Disease | Natural Medicine
Browse our Fetuin A ELISA KitsBrowse our Fetuin A ELISA Kits
McCawley LJ[au] - PubMed - NCBIMcCawley LJ[au] - PubMed - NCBI
Recombinant human Fetuin A protein (ab123466) | AbcamRecombinant human Fetuin A protein (ab123466) | Abcam
ENSDARG00000069293 - Zebrafish Mutation Project - Wellcome Sanger InstituteENSDARG00000069293 - Zebrafish Mutation Project - Wellcome Sanger Institute
ENSDARG00000026764 - Zebrafish Mutation Project - Wellcome Sanger InstituteENSDARG00000026764 - Zebrafish Mutation Project - Wellcome Sanger Institute
Monoclonal Anti-AHSG antibody produced in mouse clone 5D8, purified immunoglobulin, buffered aqueous solution | Sigma-AldrichMonoclonal Anti-AHSG antibody produced in mouse clone 5D8, purified immunoglobulin, buffered aqueous solution | Sigma-Aldrich
GO Gene ListGO Gene List
GO Gene ListGO Gene List
Bovine Fetuin A/AHSG ELISA Kit (Colorimetric) (NBP2-77017): Novus BiologicalsBovine Fetuin A/AHSG ELISA Kit (Colorimetric) (NBP2-77017): Novus Biologicals
Article | Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the...Article | Telomere attrition and decreased fetuin-A levels indicate accelerated biological aging and are implicated in the...
Baik SH[au] - PubMed - NCBIBaik SH[au] - PubMed - NCBI
Fetuin - WikipediaFetuin - Wikipedia
Enamel proteome shows that Gigantopithecus was an early diverging pongine | NatureEnamel proteome shows that Gigantopithecus was an early diverging pongine | Nature
SMART: CY domain annotationSMART: CY domain annotation
AHSG - PrimePCR Assay and Template | Life Science | Bio-RadAHSG - PrimePCR Assay and Template | Life Science | Bio-Rad
Ahsg - ddPCR Probe - Digital PCR | PrimePCR | Bio-RadAhsg - ddPCR Probe - Digital PCR | PrimePCR | Bio-Rad
Mapping and Identification of the Urine Proteome of Prostate Cancer Patients by 2D PAGE/MSMapping and Identification of the Urine Proteome of Prostate Cancer Patients by 2D PAGE/MS
nature.com searchnature.com search
CAIRO LIVER DEVELOPMENT DNCAIRO LIVER DEVELOPMENT DN
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
alpha-2-HS-Glycoproteinalpha-FetoproteinsBlood ProteinsLatexGlycoproteinsMolecular Sequence DataAmino Acid SequenceSequence Homology, Nucleic AcidTrypsinbeta 2-Glycoprotein IViral Envelope Proteinsalpha 1-AntitrypsinPlatelet Glycoprotein GPIb-IX ComplexGlycopeptidesOrosomucoidMembrane GlycoproteinsBase SequenceMyelin-Associated GlycoproteinReceptors, Adrenergic, alphaGlycosylationPlatelet Membrane GlycoproteinsAntibodies, MonoclonalCell LinePlatelet Glycoprotein GPIIb-IIIa ComplexHypoxia-Inducible Factor 1, alpha SubunitEncyclopedias as TopicChoroid PlexusProprotein ConvertasesCerebrospinal FluidEnzyme-Linked Immunosorbent AssayReagent Kits, DiagnosticDiabetes MellitusDiabetes Mellitus, Type 2Cinnamomum zeylanicumDiabetes Mellitus, Type 1Diabetes ComplicationsDiabetes Mellitus, ExperimentalGlycosidesPubMedPeriodicals as TopicBooksPublishingMEDLINESerial PublicationsBiological Science DisciplinesArtificial IntelligenceProteomicsSupport Vector MachinesAlgorithmsPattern Recognition, AutomatedComputational BiologyGenomics
AHSGFetuinAlpha2-HSExpressionSerumELISA KitHepatocytesProteinsAsialofetuinPrecursorAlbuminCystatinAntibodyBiomarkerKininogenInflammationHumanTumorBoneInter-alpha-trypsin inhibitor heavyMetabolismTissuesGenesTypeSurvivalPolymorphismMeSHRatsCirculationGeneticFibrinogenPatients
AHSG2
Fetuin2
Alpha2-HS1
Expression1
Serum6
ELISA Kit1
  • context" : "http://schema.org", "@type" : "Product", "name" : " Bovine Alpha-lactalbumin (LALBA) ELISA Kit", "image" : "https://www.elisagenie. (elisagenie.com)
Hepatocytes3
  • In particular the role of IL-6 on gene expression and production of a glycoprotein, fetuin-A produced by hepatocytes, was investigated by culturing hepatocytes in the membrane bioreactor, both in the absence and presence of IL-6 (300 pg/ml). (elsevier.com)
  • However, Sirt1 activities were increased in hepatocytes treated with low-dose NR. Hepatic pro-inflammatory markers including tumor necrosis factor-alpha and interleukin-6 were decreased in NR-treated cells. (bvsalud.org)
  • NR increased levels of mitochondrial markers including peroxisome proliferator-activated receptor γ coactivator-1α, carnitine palmitoyltransferase 1, uncoupling protein 2, transcription factor A, mitochondrial and mitochondrial DNA in PA-treated hepatocytes. (bvsalud.org)
Proteins6
  • Time-course differences in adipose tissue protein abundance were revealed between fetal genotypes for a few secreted proteins participating in responses to organic substances, such as alpha-2-HS-glycoprotein, transferrin and albumin. (springer.com)
  • However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. (embl-heidelberg.de)
  • It can be viewed as modified ultrafiltrate of plasma combined with proteins derived from kidney and urinary tract, with protein concentration approximately 1000-fold lower than in plasma itself [ 2 ]. (hindawi.com)
  • Three out of nine proteins identified to associate with HDL-4-Apo A-2 are involved in the regulation of fibrinolysis, namely, the plasmin regulator, alpha-2-antiplasmin, and two major components of the kallikrein-kinin pathway (coagulation factor XI and prekallikrein), and their physical presence in the HDL-4 subfraction was confirmed. (bmj.com)
  • Bone matrix, proteins such as Alpha 2 HS glycoprotein, osteonectin, and Type 1 collagen are chemotatic factors for monocytes and macrophages (Malone et al, J. Cell Bio. (google.com)
  • Two pools of saliva from female mice (2 samples/pool) and 2 pools of saliva from male mice were used for analysis utilizing high performance liquid chromatograph mass spectrometry (nano-RPLC-MS/MS). The resulting datasets identified 345 proteins: 174 proteins were represented in saliva obtained from both sexes, as well as 82 others that were more female specific and 89 that were more male specific. (biomedcentral.com)
Asialofetuin1
Precursor1
Albumin1
Cystatin1
Antibody1
  • Compare results from immunehistology with data of liquid samples screened in an ELISA with the same antibody, MoAb 2 from Biosensis. (artimmun.de)
Biomarker1
  • 2. The method of claim 1, wherein the quantitating step further includes the steps of indicating the binding of the autoantibody biomarker by the polypeptide marker antigen with a signal generating system, and analyzing the signals produced by the signal generating system with a signal analysis system. (freepatentsonline.com)
Kininogen1
Inflammation1
  • 28-32 In this section, we review this new data and also highlight distinctions between the LDLR −/− and apoE −/− murine disease models 33 ( Table 2 ) that provide insights into the mechanistic complexities of inflammation-dependent arterial calcium accumulation. (ahajournals.org)
Human4
  • Posttranslational processing of human alpha 2-HS glycoprotein (human fetuin). (wikipedia.org)
  • The large number of genome-wide association studies (GWAS) performed have resulted in the identification of hundreds of SNPs that are associated with human traits and diseases ( 1 , 2 ). (pnas.org)
  • Biosensis human, mouse and rat ELISAs for soluble antigen monitoring are available in 2 sizes, 1x96 and 2x96 wells. (artimmun.de)
  • DeBruijn HA, Sleijfer DT, Koops HS, Suurmeijer AJH, Marrink J, Ockhuizen T (1985) Significance of human chorionic gonadotropin, alpha-fetoprotein, and pregnancy-specific beta-1-glycoprotein in the detection of tumor relapse and partial remission in 126 patients with nonsemi-nomatous testicular germ cell tumors. (springer.com)
Tumor1
  • The standard treatment confers the patients a median overall survival time of 15 months [ 2 ], due to tumor cells that survive initial chemo- and radiotherapy causing tumor regrowth/recurrence. (oncotarget.com)
Bone1
  • A significant upregulation of Osteoactivin, a gene related to bone mineralization, was found in aged rats (both control and task), while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. (cdc.gov)
Inter-alpha-trypsin inhibitor heavy1
Metabolism1
  • 2,3 Although vascular calcification was once considered only a passive process of dead and dying cells, work from laboratories worldwide has now highlighted that arterial biomineralization is an actively regulated form of calcified tissue metabolism. (ahajournals.org)
Tissues1
Genes1
  • The linkage disequilibrium (LD) maps of these two genes were built with Haploview using data on CHB+JPT (version 2) from the HapMap. (cdc.gov)
Type9
  • Danish hospital researchers have proven that the typical recommendation among conventional doctors and nutritionists to type 2 diabetics to lay off the fruit is quite simply wrong. (greenmedinfo.com)
  • New research from the West Virginia University School of Medicine has confirmed other research finding that Bisphenol A (BPA) - found among various plastics and resins in consumer goods - may lead or contribute to both type 1 and type 2 diabetes. (greenmedinfo.com)
  • The research is quite clear - oral medications to treat type 2 diabetes do not alter the long-term progression of the disease. (greenmedinfo.com)
  • Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. (nih.gov)
  • Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Patients. (nih.gov)
  • Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. (springermedizin.de)
  • Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (springermedizin.de)
  • However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown. (nih.gov)
  • Previous epidemiological studies have found a positive association between blood fetuin-A and type 2 diabetes mellitus (T2DM) risk among Caucasians and African Americans. (bvsalud.org)
Survival1
  • The small HDL subclass rich in apolipoprotein A-2 content (HDL-4-Apo A-2) exhibited the most significant association with survival. (bmj.com)
Polymorphism1
MeSH1
Rats1
  • and 3) task performance in aged rats only (corticotropin releasing hormone, interleukin 4, interferon regulatory factor 1, inhibin alpha, and interleukin 6). (cdc.gov)
Circulation1
  • Due to the fact that both the hypersensitivity reaction and the peak of lipoproteins in circulation occur ~5 hours postprandial, we hypothesize that the alpha-gal molecules are transported via intestinal lipoproteins. (etsu.edu)
Genetic1
  • The calcification became drastically exacerbated when the fetuin-A knockout was combined with the genetic background DBA/2. (wikipedia.org)
Fibrinogen1
Patients5
  • 2,4,11 We end by summarizing the importance of considering these disease stage- and context-specific contributions arterial mineralization when crafting therapeutic strategies to address the disease burden of vascular calcification that increasingly afflicts our patients. (ahajournals.org)
  • Patients who developed a hypersensitivity reaction to red meat were found to have a high titer of galactose-1,3- alpha-glacatose (alpha-gal) IgE. (etsu.edu)
  • The results showed that there was a spontaneous increase of serotonin 2 h after the insertion of the catheter in patients with TMD. (diva-portal.org)
  • The mortality rate among dialysis patients is obviously more than that of the general population and cardiovascular diseases are the leading causes of mortality among dialysis patients [ 1 , 2 ]. (alliedacademies.org)
  • Despite an initial response to primary, or "first-line", treatment more than 85% of patients with advanced disease will experience OVCA recurrence after the completion of first-line treatment even with optimal surgical cytoreduction and platinum-based combination chemotherapy (2,3). (freepatentsonline.com)
Scientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient Code
Scientists genetically link orangutans to giant ape thought to be Bigfoot - Ancient Code (ancient-code.com)
Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...
Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses... (link.springer.com)
Browse our Fetuin A ELISA Kits
Browse our Fetuin A ELISA Kits (antibodies-online.com)
Results for 'Adaptive immune components ELISA kits' | Abcam: antibodies, proteins, kits...
Results for 'Adaptive immune components ELISA kits' | Abcam: antibodies, proteins, kits... (abcam.com)
GO Gene List
GO Gene List (cgap.nci.nih.gov)
Bovine Fetuin A/AHSG ELISA Kit (Colorimetric) (NBP2-77017): Novus Biologicals
Bovine Fetuin A/AHSG ELISA Kit (Colorimetric) (NBP2-77017): Novus Biologicals (novusbio.com)
SMART: CY domain annotation
SMART: CY domain annotation (smart.embl-heidelberg.de)
AHSG - PrimePCR Assay and Template | Life Science | Bio-Rad
AHSG - PrimePCR Assay and Template | Life Science | Bio-Rad (bio-rad.com)
AHSG monoclonal antibody (M01), clone 5D8 - (H00000197-M01) - Products - Abnova
AHSG monoclonal antibody (M01), clone 5D8 - (H00000197-M01) - Products - Abnova (abnova.com)
Table of Contents | Cancer Epidemiology, Biomarkers & Prevention
Table of Contents | Cancer Epidemiology, Biomarkers & Prevention (cebp.aacrjournals.org)
Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |...
Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |... (bmccancer.biomedcentral.com)
A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data | BMC Genomics |...
A machine learning heuristic to identify biologically relevant and minimal biomarker panels from omics data | BMC Genomics |... (bmcgenomics.biomedcentral.com)
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs...
REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs... (ard.bmj.com)
Recombinant Human AHSG cell lysate AHSG-2958HCL - Creative BioMart
Recombinant Human AHSG cell lysate AHSG-2958HCL - Creative BioMart (creativebiomart.net)
Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis | BMC...
Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis | BMC... (bmcgenomics.biomedcentral.com)
Fetuin A/AHSG Human HEK293 cells | BioVendor
Fetuin A/AHSG Human HEK293 cells | BioVendor (biovendor.com)
DiVA - Search result
DiVA - Search result (liu.diva-portal.org)
ExoMS Surface Protein Capture Kit (Tissue Culture) | System Biosciences
ExoMS Surface Protein Capture Kit (Tissue Culture) | System Biosciences (systembio.com)
Frontiers | Skin Mucus of Gilthead Sea Bream (Sparus aurata L.). Protein Mapping and Regulation in Chronically Stressed Fish |...
Frontiers | Skin Mucus of Gilthead Sea Bream (Sparus aurata L.). Protein Mapping and Regulation in Chronically Stressed Fish |... (frontiersin.org)
ARTIMMUN ANALYTIK GmbH: ELISAs
ARTIMMUN ANALYTIK GmbH: ELISAs (artimmun.de)
Alpha-2-HS-Glycoprotein | Profiles RNS
Alpha-2-HS-Glycoprotein | Profiles RNS (profiles.uchicago.edu)
Zur deutschen Internetseite wechseln
Zur deutschen Internetseite wechseln (acris-antikoerper.de)
Anti UDP N Acetyl alpha D Galactosaminepolypeptide N Acetylgalactosaminyltransferase 6 GalNAc T6 GALNT6 - Journal for the...
Anti UDP N Acetyl alpha D Galactosaminepolypeptide N Acetylgalactosaminyltransferase 6 GalNAc T6 GALNT6 - Journal for the... (ialltjournal.org)
Scientists hit on the protein and lipid composition of the Siberian mammoth bone - Moscow Institute of Physics and Technology
Scientists hit on the protein and lipid composition of the Siberian mammoth bone - Moscow Institute of Physics and Technology (mipt.ru)
Application # 2011/0245592. Secretome Profile-Facilitated In Vitro Fertilization - Patents.com
Application # 2011/0245592. Secretome Profile-Facilitated In Vitro Fertilization - Patents.com (patents.com)
Find Research Outputs - Kyushu University
Find Research Outputs - Kyushu University (kyushu-u.pure.elsevier.com)
Eccrine Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Eccrine Adenocarcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials (malacards.org)
Ikehata, M.<...
Ikehata, M.<... (moh-it.pure.elsevier.com)