A fetuin subtype that is synthesized by HEPATOCYTES and secreted into the circulation. It plays a major role in preventing CALCIUM precipitation in the BLOOD.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.
Glycoproteins found on the membrane or surface of cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A myelin protein found in the periaxonal membrane of both the central and peripheral nervous systems myelin sheaths. It binds to cells surface receptors found on AXONS and may regulate cellular interactions between MYELIN and AXONS.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.
Antibodies produced by a single clone of cells.
Established cell cultures that have the potential to propagate indefinitely.
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The tree which is known for its bark which is sold as cinnamon. The oil contains about 65-80% cinnamaldehyde and 10% EUGENOL and many TERPENES.
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

Positive and negative elements modulate the promoter of the human liver-specific alpha2-HS-glycoprotein gene. (1/175)

The human alpha2-HS-glycoprotein (AHSG) and the 63-kDa rat phosphoprotein (pp63) are homologous plasma proteins that belong to the fetuin family. AHSG and pp63 are involved in important functions such as inhibition of insulin receptor tyrosine kinase activity, inhibition of protease activities, and regulation of calcium metabolism and osteogenesis. Studies of the AHSG proximal promoter performed in vitro in rat and human cells indicate that several NF-1 and C/EBP binding sites exert a positive effect on its transcriptional activity. However, until now, no distal elements have been examined in this gene, in either species. We report that the human AHSG gene promoter acts in a liver-specific manner and is further controlled by three distal, 5'-flanking elements. The negative elements III and I are, respectively, located 5' and 3' of the positive element II. All three elements require the natural context of the human AHSG gene to fully exert their negative or positive effect. Element I harbours a single binding site for NF-1. This nuclear factor thus appears to be able to up- or downregulate the AHSG gene depending on the site it binds to. Elements I, II and possibly III are absent in the rodent Ahsg gene encoding pp63.  (+info)

Phosphorylation of human plasma alpha2-Heremans-Schmid glycoprotein (human fetuin) in vivo. (2/175)

A fraction of alpha2-Heremans-Schmid (alpha2-HS) glycoprotein (human fetuin) isolated from plasma was phosphorylated at serine-120 and serine-312 as shown by MS and peptide fragment sequencing after tryptic digestion. Serine-312-containing peptides were phosphorylated to 77% as determined from relative peak heights in the mass spectrum, which together with the phosphorylation of serine-120 implies a molar degree of phosphorylation of at least 1. Approximately 20% of the circulating fetuin plasma pool was phosphorylated to approx. 1 mol of phosphate/mol of protein. The remainder did not contain phosphate, resulting in an average phosphorylation degree for the protein in plasma of approx. 0.2 mol/mol. The isolated alpha2-HS glycoprotein was a heterodimer in which the entire C-terminal part of the connecting peptide including threonine-321 was present, but traces of C-terminally trimmed connecting peptide fragments were also found. The short B-chain was O-glycosylated to approx. 40%, whereas the N-glycosylation of asparagine-138 and asparagine-158 seemed to be 100%. This finding, for the first time, that circulating human plasma fetuin is partly phosphorylated, implies that the effects of phosphorylated alpha2-HS glycoprotein on insulin signal transduction seen in different cell systems could be relevant to its physiological function in vivo.  (+info)

Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human alpha2-HS glycoprotein. (3/175)

Fetuin/alpha2-HS glycoprotein (alpha2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb Bgl II fragment contained exons 2, 3 and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of (T,C)n*(A,G)n. We have mapped mouse Ahsg at 16 cM adjacent to the Diacylglycerol kinase 3 (Dagk3) gene on chromosome 16 by genotyping interspecific backcross panels between C57BL/6J and Mus spretus. The position is syntenic with human chromosome 3q27, where the human AHSG gene resides. Using recombinant mouse alpha2-HSG expressed from a recombinant baculovirus, we demonstrate that mouse alpha2-HSG inhibits insulin-stimulated IR autophosphorylation and IR-TKA in vitro. In addition, mouse alpha2-HSG (25 microg/ml) completely abolishes insulin-induced DNA synthesis in H-35 rat hepatoma cells. Based on the sequence data and functional analysis, we conclude that the mouse Ahsg gene is the true ortholog of the human AHSG gene.  (+info)

alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling. (4/175)

Soluble transforming growth factor-beta (TGF-beta)/bone morphogenetic protein (BMP)-binding proteins are widely distributed in mammalian tissues and control cytokine access to membrane signaling receptors. The serum and bone-resident glycoprotein alpha2-HS-glycoprotein/fetuin (ASHG) binds to TGF-beta/BMP cytokines and blocks TGF-beta1 binding to cell surface receptors. Therefore, we examined bone growth and remodeling phenotypes in ASHG-deficient mice. The skeletal structure of Ahsg(-/-) mice appeared normal at birth, but abnormalities were observed in adult Ahsg(-/-) mice. Maturation of growth plate chondrocytes was impaired, and femurs lengthened more slowly between 3 and 18 months of age in Ahsg(-/-) mice. However, bone formation was increased in Ahsg(-/-) mice as indicated by greater cortical thickness, accelerated trabecular bone remodeling, and increased osteoblast numbers on bone surfaces. The normal age-related increase in cortical thickness and bone mineral density was accelerated in Ahsg(-/-) mice and was associated with increased energy required to fracture. Bone formation in response to implanted BMP cytokine extended further from the implant in Ahsg(-/-) compared with Ahsg(+/+) mice, confirming the interaction between ASHG and TGF-beta/BMP cytokines in vivo. Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.  (+info)

Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. (5/175)

Fetuin inhibits insulin-induced insulin receptor (IR) autophosphorylation and tyrosine kinase activity in vitro, in intact cells, and in vivo. The fetuin gene (AHSG) is located on human chromosome 3q27, recently identified as a susceptibility locus for type 2 diabetes and the metabolic syndrome. Here, we explore insulin signaling, glucose homeostasis, and the effect of a high-fat diet on weight gain, body fat composition, and glucose disposal in mice carrying two null alleles for the gene encoding fetuin, Ahsg (B6, 129-Ahsg(tm1Mbl)). Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle. Glucose and insulin tolerance tests in fetuin KO mice indicate significantly enhanced glucose clearance and insulin sensitivity. Fetuin KO mice subjected to euglycemic-hyperinsulinemic clamp show augmented sensitivity to insulin, evidenced by increased glucose infusion rate (P = 0.077) and significantly increased skeletal muscle glycogen content (P < 0.05). When fed a high-fat diet, fetuin KO mice are resistant to weight gain, demonstrate significantly decreased body fat, and remain insulin sensitive. These data suggest that fetuin may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation and may be a novel therapeutic target in the treatment of type 2 diabetes, obesity, and other insulin-resistant conditions.  (+info)

Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes. (6/175)

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.  (+info)

Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles. (7/175)

Genetic evidence from mutant mice suggests that alpha(2)-HS glycoprotein/fetuin-A (Ahsg) is a systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted calcification. Using electron microscopy and dynamic light scattering, we demonstrate that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate. These "calciprotein particles" of 30-150 nm in diameter are initially amorphous and soluble but turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion. Solubilization in Ahsg-containing calciprotein particles provides a novel conceptual framework to explain how insoluble calcium precipitates may be transported and removed in the bodies of mammals. Mutational analysis showed that the basic calcium phosphate precipitation inhibition activity resides in the amino-terminal cystatin-like domain D1 of Ahsg. A structure-function analysis of wild type and mutant forms of cystatin-like domains from Ahsg, full-length fetuin-B, histidine-rich glycoprotein, and kininogen demonstrated that Ahsg domain D1 is most efficient in inhibiting basic calcium phosphate precipitation. The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition.  (+info)

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. (8/175)

Ectopic calcification is a frequent complication of many degenerative diseases. Here we identify the serum protein alpha2-Heremans-Schmid glycoprotein (Ahsg, also known as fetuin-A) as an important inhibitor of ectopic calcification acting on the systemic level. Ahsg-deficient mice are phenotypically normal, but develop severe calcification of various organs on a mineral and vitamin D-rich diet and on a normal diet when the deficiency is combined with a DBA/2 genetic background. This phenotype is not associated with apparent changes in calcium and phosphate homeostasis, but with a decreased inhibitory activity of the Ahsg-deficient extracellular fluid on mineral formation. The same underlying principle may contribute to many calcifying disorders including calciphylaxis, a syndrome of severe systemic calcification in patients with chronic renal failure. Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases.  (+info)

Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports were inconsistent. Two hundred seven subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t-test or Nonparametric test was used to detect differences between PCOS and control groups. Spearmans correlation analysis was used to examine the association of the serum Fetuin-A with other parameters. Our findings showed that circulating Fetuin-A concentration ranged from 196.6 to 418.2 μg/L for most women without PCOS (95%). Women with PCOS had higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p | 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T, and DHEA-S.
The association between the development of diabetic foot and serum fetuin-A levels. Ozenç S, Simsek K, Yildirim A, Arslan E, Sari S, Ince M, Sarı O, Yeşilkaya S, Aydoğan U, Yaman H, Koç B, Sağlam K. Pol Arch Med Wewn. […]
alpha-2-HS-glycoprotein (AHSG) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. Fetuin-A belongs to the fetuin class of plasma binding proteins and is more abundant in fetal than adult blood. Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. The choroid plexus is an established extrahepatic expression site. The mature circulating AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a ...
Objectives: The contribution of vascular disease to neurocognitive decline is now widely recognized. Fetuin-A is an abundant plasma protein known to predict vascular disease. Prior studies have shown that fetuin-A levels are lower in patients with Alzheimers disease in direct proportion to the severity of cognitive impairment; however, their association with normal cognitive aging is unknown. We evaluated the association of serum fetuin-A levels with cognitive function in relatively high-functioning, community-dwelling older adults from the Rancho Bernardo Study.. Methods: This is a population-based study of 1382 older adults (median age 75) who had plasma fetuin-A levels and cognitive function evaluated in 1992-96; 855 had repeat cognitive function assessment a median of 4 years later.. Results: Adjusting for age, sex, education, and depression, higher levels of fetuin-A were associated with better baseline performance on the Mini-Mental Status Exam (MMSE) (P=0.012) and a tendency for better ...
Vascular stiffening occurs in normal ageing and is accelerated in chronic kidney disease (CKD). Vascular calcification contributes to this stiffening and to the high incidence of vascular morbidity and mortality in this population. A network of inhibitors work in concert to reduce mineralization risk in extra-osseous tissue. Fetuin-A is an important systemic inhibitor of ectopic calcification. A fraction of the total circulating fetuin-A interacts with mineral ions to form stable colloidal complexes, calciprotein particles (CPP), preventing deposition. We sought to assess whether CPP fetuin-A levels were associated with procalcific factors and aortic stiffness in a cohort of patients with Stages 3 and 4 CKD.. ...
Context: Fetuin-A inhibits the insulin receptor in vitro. Higher serum fetuin-A concentrations are associated with type 2 diabetes longitudinally and greater adiposity in cross-sectional analyses. Whether higher fetuin-A concentrations are associated with accumulation of adiposity over time is unknown. Objective: To determine the association of fetuin-A levels with changes in body composition over 5 yr. Study Design: Observational cohort study nested in the Health Aging and Body Composition Study.
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A total of 32 studies including 27 case-control and 5 cohort studies were included in the current study. Fetuin-A levels in T2D patients were significantly higher than control groups [Hedges g = 1.73, 95% CI (1.25-2.22), P , 0.001], with significant heterogeneity across studies (P , 0.001, I 2 = 98.46%). Findings from meta-analyses of cohort studies showed a statistically significant association between fetuin-A levels and T2D risk [rate ratio = 1.62, 95% CI (1.26-2.08), P , 0.001], with no significant heterogeneity (P = 0.10, I 2 = 46.06%).. ...
Haplotype analysis of the human α2-HS glycoprotein (fetuin) gene - Volume 65 Issue 1 - M. OSAWA, I. YUASA, T. KITANO, J. HENKE, M. KANEKO, T. UDONO, N SAITOU, K. UMETSU
The use of A2HS as an additional polymorphic marker in paternity testing and related forensic applications is not yet introduced in the routine expertises of all laboratories. One of several causes...
The serum glycoprotein fetuin-A is an important inhibitor of extra-osseous calcification, but correlations between serum fetuin-A levels and the extent of vascular calcification are controversial. In this study, we used a rat model of adenine-induced renal failure with secondary hyperparathyroidism …
article{f963b6fc-e756-4df4-ac43-a0f6062f09ae, abstract = {,p,Aims/hypothesis: Sleep duration is a risk factor for incident diabetes mellitus and CHD. The primary aim of the present study was to investigate, in sex-specific analyses, the role of incident diabetes as the possible biological mechanism for the reported association between short/long sleep duration and incident CHD. Considering that diabetes is a major risk factor for CHD, we hypothesised that any association with sleep duration would not hold for cases of incident CHD occurring before incident diabetes (non-diabetes CHD) but would hold true for cases of incident CHD following incident diabetes (diabetes-CHD). Methods: A total of 6966 men and 9378 women aged 45-73 years from the Malmö Diet Cancer Study, a population-based, prospective cohort, who had answered questions on habitual sleep duration and did not have a history of prevalent diabetes or CHD were included in the analyses. Incident cases of diabetes and CHD were ...
In 2 separate cohorts of US men and women, 3 plasma biomarkers of dairy fat, 15:0, 17:0, and trans-16:1n-7, were associated with lower risk of incident diabetes mellitus. Findings were generally similar for erythrocyte fatty acids, although with smaller and not always significant magnitudes of association. These results provide new evidence on associations of dairy-derived circulating fatty acids and risk of diabetes mellitus.. Our findings suggest that either these dairy fatty acids themselves or other correlated factors in dairy fat could reduce the risk of diabetes mellitus. For instance, short- and medium-chain saturated fats, vitamin D (a fat-soluble vitamin), omega-3 fats, or gangliosides in dairy fat could each play a role.27 The magnitudes of our associations, linear dose response, independence from established diabetes risk factors and other dietary habits, and consistency of findings across sensitivity analyses argue against residual confounding as the sole explanation for our ...
PubMed journal article Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
Problem statement: Associations between serum levels of fetuin-A, C3 complement, calcium × phosphate product and calcification risk index and lipid profile in SLE patients were established. However, the mechanism of accelerated atherosclerosis accompanied with SLE remains elusive. We therefore turned to investigate the association between Fetuin-A, disease activity and accelerated atherosclerosis in patients with SLE. Approach: Serum blood samples were taken from 100 female SLE patients. All Patient samples were analyzed by ELISA for determination of Fetuin-A level. Calcium, Phosphate, C3 compelement, Lipid profile, Creatinine and urea were measured also in SLE patients compared with healthy control volunteers. Results: We found that Serum fetuin-A had been positively associated with carotid arterial stiffness, independent of known atherogenic factors in healthy subjects. Furthermore, Fetuin-A was correlated negatively with IMT, SLEDAI, CRI, CaxP product, Triglycerdies, VLDL and LDL. While it was
Results Serum FGF-23 and fetuin-A levels were significantly increased in the CAD patients as compared with the non-CAD patients (26.7 [interquartile range, 22.4-31.9] vs 15.7 [interquartile range, 13.2-18.1] pg/mL and 904.7 [interquartile range, 695.5-1021.6] vs 469.6 [331.4-660.5] mg/L, respectively; P , 0.001 for both). Furthermore, a positive correlation was identified between FGF-23 and fetuin-A levels and the total number of plaques (r = 0.21 and r = 0.28, respectively; P , 0.001 for both). In multivariate logistic regression analysis, age, smoking status, uric acid, FGF-23, and fetuin-A levels were found to be independently associated with the presence of CAD. ...
Among well-functioning older persons, serum fetuin-A is associated with incident diabetes, independent of other markers of insulin resistance.
Hypotheses regarding the relationships between Gigantopithecus and extinct and extant hominids are wide ranging but difficult to substantiate because of its highly derived dentognathic morphology, the absence of cranial and post-cranial remains and the lack of independent molecular validation.. We retrieved dental enamel proteome sequences from a 1.9-million-year-old G. blacki molar found in Chuifeng Cave, China. The thermal age of these protein sequences is approximately five times greater than that of any previously published mammalian proteome or genome. We demonstrate that Gigantopithecus is a sister clade to orangutans (genus Pongo) with a common ancestor about 12-10 million years ago, implying that the divergence of Gigantopithecus from Pongo forms part of the Miocene radiation of great apes.. In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel proteomes, had a role in the biomineralization of the thick enamel crowns ...
Affiliation:愛媛大学,医学部・附属病院,講師, Research Field:Urology, Keywords:尿路結石症,プロトロンビンF1,結晶形成抑制,結石溶解,Alpha 2-HS-glycoprotein,プロトロビンF1,プロトロンビン,Prothrombin,チオバチルスチオオキシダンス,dissolution of stone, # of Research Projects:2, # of Research Products:0
Decreased action of insulin in peripheral tissues is a central feature of several common pathological states, including type 2 diabetes, obesity, hypertension, and glucocorticoid excess (3,37). Improving insulin sensitivity offers a promising approach to the prevention, intervention, and treatment of these pathological conditions. Several animal models demonstrate a potential to increase insulin sensitivity, namely Pik3r1−/−, PPAR-γ+/− (peroxisome proliferator-activated receptor-γ heterozygous), PTP1B Ex1−/− (protein tyrosine phosphatase 1B knockout), and transgenic Ucp-L mice (38-42). Fetuin has irstatin (IR inhibitory) activity and interacts with the activated IR (9,17, 43). In this study, we used mice that carry two null alleles for the Ahsg gene to examine the hypothesis that deficiency of fetuin leads to increased IR autophosphorylation and downstream insulin signaling, thereby improving whole-body insulin sensitivity.. Fetuin KO mice exhibit increased insulin sensitivity, as ...
Blog on AHSG elisa kit product: The Human AHSG ahsg (Catalog #MBS701816) is an ELISA Kit and is intended for research purposes only. The ...
Abcams Alpha 2 HS Glycoprotein ELISA Kit suitable for Cell culture supernatant, Milk, Urine, Serum, Plasma, Cerebral Spinal Fluid in human. Reliably quantify…
Fetuin/α2-HS glycoprotein (α2-HSG) homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to characterize the intron-exon organization of the mouse Ahsg gene, including an 875 bp subclone containing 154 bp upstream from the transcription start site, the first exon, and part of the first intron. A second genomic subclone harboring a 3.45 kb BgI II fragment contained exons 2, 3, and 4 in addition to two adjacent elements within the first intron-a repetitive element of the B1 family (92 bp) and a 271 bp tract of
Lee, Sindre; Norheim, Frode; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Kolnes, Kristoffer Jensen; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor Duncan; Holen, Torgeir; Birkeland, Kåre I.; Jensen, Jørgen & Drevon, Christian A (2017). Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise. Physiological Reports. ISSN 2051-817X. 5(5) . doi: 10.14814/phy2.13183 Show summary The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be explained by altered release of myokines from the skeletal muscle, it is not well documented if some of the beneficial effects of exercise can be explained by altered secretion of hepatokines. The aim of this study was to examine the effect of interaction between fetuin‐A and FFAs on insulin sensitivity after ...
Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Weaving, Gary, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2011) Instability of fibroblast growth factor-23 (FGF-23): implications for clinical studies. Clinica Chimica Acta, 412 (11-12). pp. 1008-1011. ISSN 1873-3492 Smith, Edward R, Ford, Martin L, Tomlinson, Laurie A, Rocks, Bernard F, Rajkumar, Chakravarthi and Holt, Stephen G (2010) Poor agreement between commercial ELISAs for plasma fetuin-A: an effect of protein glycosylation? Clinica Chimica Acta, 411 (17-18). pp. 1367-1370. ISSN 0009-8981 Shams, Sedigheh, Shafi, Shahida, Bodman-Smith, Kikki, Williams, Peter, Mehta, Sweta and Ferns, Gordon A (2008) Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: association with established cardiovascular risk factors. Clinica Chimica Acta, 395 (1-2). pp. 42-46. ISSN 0009-8981 ...
In this study, we demonstrated that patients with type 2 diabetes who additionally suffer from PAD have significantly higher fetuin-A levels than patients with diabetes but without any atherosclerotic burden.. Our data are in opposition to the results from Eraso et al. (14), who assumed that patients with type 2 diabetes and PAD have lower plasma concentrations of fetuin-A than patients with type 2 diabetes alone. In the latter study, 738 patients with type 2 diabetes but without clinical evidence of cardiovascular disease were enrolled. From these study participants, only 5.1% (n = 38) had PAD, defined by an ABI ,0.9. Although PAD patients show the highest co-burden of manifestations of atherosclerosis (15), which is even higher in patients with PAD and type 2 diabetes (1-3,15), the 38 patients in the latter article did not show any other manifestation of atherosclerosis and must thus be regarded as highly selected and not representative (20).. In contrast to Eraso et al. (14), a decrease of ...
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Looking for online definition of alpha-2HS glycoprotein in the Medical Dictionary? alpha-2HS glycoprotein explanation free. What is alpha-2HS glycoprotein? Meaning of alpha-2HS glycoprotein medical term. What does alpha-2HS glycoprotein mean?
Objective Fetuin-A is associated with body mass index (BMI) as well as components of the metabolic syndrome. However, it is unclear if fetuin-A affects BMI or the other way around. We therefore assessed the causal association between fetuin-A and BMI or vice versa, utilizing a bidirectional Mendelian randomization approach. Design and Methods This was a study of 2558 subjects from the Electricity Generating Authority of Thailand (EGAT) cohort. Two polymorphisms, that is, rs2248690 in the alpha2-Hereman-Schmid glycoprotein (AHSG) gene and rs9939609 in the fat mass and obesity-associated (FTO) gene were genotyped. Bidirectional causal models were constructed using a two-stage least-square instrumental variable (IV) regression. First, rs2248690 locus was used as the instrumental variable for the effect of circulating fetuin-A on BMI, and then, the FTO rs9939609 locus was used as the instrumental variable for the effect of BMI on circulating fetuin-A. Results Among the 2558 subjects, the prevalence ...
In this 8-week randomized trial of overweight men and women, adiponectin and IL-6 levels increased for the caffeinated coffee group as compared with the group receiving no coffee. Fetuin-A levels decreased for decaffeinated coffee as compared with no coffee at the end of the intervention. There were no significant differences between the three treatment groups for CRP or measures of glucose metabolism.. Our results for adiponectin are consistent with one observational study and non-randomized trial that found higher adiponectin concentrations with increasing coffee consumption [8, 10]. The effects of coffee on fetuin-A concentrations in our trial are consistent with the beneficial effects of coffee on liver function suggested by cross-sectional studies of coffee consumption and liver enzymes [9]. The lack of significant effects of coffee consumption on glucose tolerance may seem inconsistent with the effect of coffee consumption on adiponectin levels and the association between increases in ...
OBJECTIVE: To examine the correlation of plasma fibroblast growth factor (FGF)-23 and serum fetuin A levels with the coronary artery calcification score (CACS) in patients with normal kidney function. BACKGROUND: Vascular calcification is an active process that may be aggravated by hyperphosphataemia and hypercalcaemia. FGF-23 and human fetuin-A have been associated with calcifying arteriosclerosis in renal failure. Plasma FGF-23 was identified as an independent factor negatively associated with peripheral vascular calcification. Fetuin-A acts as a systemic inhibitor of ectopic calcification in dialysis patients and can be correlated to the survival of these patients. Very few data exists on the role of FGF-23 and fetuin-A in coronary calcification of patients without impaired kidney function. MATERIALS AND METHODS: Sixty-four patients, 21 females and 43 males, were subjected to 64-slice coronary computed tomography (CT) to evaluate coronary artery calcification (CAC). Plasma intact FGF-23 was ...
Approach and Results-Immunohistochemistry and quantitative polymerase chain reaction showed that GRP expression and accumulation are upregulated with calcification simultaneously with osteocalcin and matrix Gla protein (MGP). Using conformation-specific antibodies, both γ-carboxylated GRP and undercarboxylated GRP species were found accumulated at the sites of mineral deposits, whereas undercarboxylated GRP was predominant in calcified aortic valve disease valvular interstitial cells. Mineral-bound GRP, MGP, and fetuin-A were identified by mass spectrometry. Using an ex vivo model of vascular calcification, γ-carboxylated GRP but not undercarboxylated GRP was shown to inhibit calcification and osteochondrogenic differentiation through α-smooth muscle actin upregulation and osteopontin downregulation. Immunoprecipitation assays showed that GRP is part of an MGP-fetuin-A complex at the sites of valvular calcification. Moreover, extracellular vesicles released from normal vascular smooth muscle ...
A Fetuin subtype that is synthesized by Hepatocytes and secreted into the circulation. It plays a major Role in preventing Calcium precipitation in the Blood ...
Kaufmann-Peterson [base]; Keratitic Precipitate; Keratitis Punctata; Kidney Protein; Killed Parenteral [vaccine]; Klebsiella ...
TY - JOUR. T1 - Can dietary omega-3 fatty acids modulate fetuin-a protein?. AU - Singh, R. B.. AU - DeMeester, Fabien. AU - Pella, Daniel. AU - Basu, Tapan K.. AU - Watson, Ronald R. PY - 2011. Y1 - 2011. UR - http://www.scopus.com/inward/record.url?scp=79961162330&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79961162330&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:79961162330. VL - 4. SP - 175. EP - 176. JO - World Heart Journal. JF - World Heart Journal. SN - 1556-4002. IS - 3. ER - ...
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TY - JOUR. T1 - Targeting of the osteoclastogenic RANKL-RANK axis prevents osteoporotic bone loss and soft tissue calcification in coxsackievirus B3-infected mice. AU - Lee, Kyunghee. AU - Kim, Hyunsoo. AU - Park, Ho Sun. AU - Kim, Keuk Jun. AU - Song, Hoogeun. AU - Shin, Hong In. AU - Kim, Han Sung. AU - Seo, Donghyun. AU - Kook, Hyun. AU - Ko, Jeong Hyeon. AU - Jeong, Daewon. PY - 2013/2/15. Y1 - 2013/2/15. N2 - Bone mineralization is a normal physiological process, whereas ectopic calcification of soft tissues is a pathological process that leads to irreversible tissue damage. We have established a coxsackievirus B3 (CVB3)-infected mouse model that manifests both osteoporosis and ectopic calcification specifically in heart, pancreas, and lung. The CVB3-infected mice showed increased serum concentrations of both cytokines including IL-1β, TNF-α, and the receptor activator of NF-κB ligand (RANKL) that stimulate osteoclast formation and of the osteoclast-derived protein tartrate-resistant ...
Approach and Results-We adapted Egger regression, a technique frequently used in Mendelian randomization studies to detect genetic pleiotropy, to reanalyze the available randomized control trial data of statin therapy. For cardiovascular end points, each 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 0.77 (95% confidence interval, 0.71-0.84) with an intercept that was indistinguishable from zero (intercept, −0.0032; [95% confidence interval, −0.090 to 0.084]; P=0.94), indicating no pleiotropy. For incident diabetes mellitus, a 1 mmol/L change in LDL-C with statin therapy was associated with a hazard ratio of 1.07 (95% confidence interval, 0.99-1.16) and an intercept nondistinguishable from zero (intercept, −0.015; [95% confidence interval, −0.30 to 0.27]; P=0.91), again indicating no pleiotropy. ...
Cardiovascular calcification is prevalent in the aging population and in patients with chronic kidney disease (CKD) and diabetes mellitus, giving rise to substantial morbidity and mortality. Vitamin K-dependent matrix Gla-protein (MGP) is an important inhibitor of calcification. The aim of this study was to evaluate the impact of high-dose menaquinone-7 (MK-7) supplementation (100 µg/g diet) on the development of extraosseous calcification in a murine model. Calcification was induced by 5/6 nephrectomy combined with high phosphate diet in rats. Sham operated animals served as controls. Animals received high or low MK-7 diets for 12 weeks. We assessed vital parameters, serum chemistry, creatinine clearance, and cardiac function. CKD provoked increased aortic (1.3 fold; p < 0.05) and myocardial (2.4 fold; p < 0.05) calcification in line with increased alkaline phosphatase levels (2.2 fold; p < 0.01). MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline
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Ahaneku G.I., Osuji C.U., Anisiuba B.C., Ikeh V.O., Oguejiofor O.C. and Ahaneku J.E., (2011). Evaluation of blood pressure and indices of obesity in a typical rural community in eastern Nigeria. Ann. Afr. Med. 10 (2): 120-6.. Allain C.C., Poon L.S., Chain C.S.G., Richmond W,. and Fu P.C., (1974). Enzymatic etermination of the serum cholesterol. Clin. Chem. 20(4): 470-475.. Barham D. and Trinder P., (1972). Clinical guide to laboratory test. Analyst 97: 142.. Barzilay J.I., Davis B.R., Cutler J.A., Pressel S.L., Whelton P.K., Basile J., Margolis KL., Ong S.T., Sadler L.S. and Summerson J., (2006). Fasting glucose levels and incident diabetes mellitus in older non-diabetic adults randomized to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-Lowering Treatment to prevent Heart Attack Trial (ALLHAT). Ach. Intern. Med. 166(20): 2191-2201.. Benson S.C., Pershadsingh H.A., Chittiboyina A., Desai P., Pravenec M., Qi N., Wang J., Avery M.A. and ...
TY - JOUR. T1 - Fetuin-a expression profile in mouse and human adipose tissue. AU - Khadir, Abdelkrim. AU - Kavalakatt, Sina. AU - Madhu, Dhanya. AU - Tiss, Ali. PY - 2020/3/12. Y1 - 2020/3/12. N2 - Fetuin-A (Fet-A) was one of the first hepatokines to be reportedly linked to metabolic diseases. Fet-A was also suggested to be an adipokine, but its expression in the adipose tissue remains debatable. Here we compared the expression of Fet-A between human and mice adipose tissue biopsies as well as among human subcutaneous tissue and visceral adipose tissue primary cells, and mouse 3 T3-L1 cells at various stages of differentiation. Fet-A was expressed in mice biopsies and cells but not in human biopsies and cells, except in visceral adipose tissue primary cells following differentiation. Although the marginal expression of Fet-A in human visceral adipose tissue, a major contribution of Fet-A expression in human adipose tissue to systemic Fet-A levels is discounted, but it could indicate specific ...
ER stress plays a crucial role in obesity, insulin resistance [27], and NAFLD [28]. The ER stress response is triggered by different stimuli such as oxidative stress, hypoxia, enhanced protein synthesis, high levels of glucose and saturated fatty acids, and high levels of ER stress inducers, such as thapsigargin and Tuni [29,30]. The ER stress response also stimulates ER stress sensors such as ATF6, phosphorylation of PERK and IRE-1α [31], and ER stress-induced transcription factors, such as CHOP and XBP-1 [32,33]. In a previous study, we demonstrated that exendin-4 has a protective effect against PA-induced ER stress in hepatocytes [34]. In cells treated with PA, changes in the expression of the ER stress markers, SEPP1 and fetuin-A showed similar patterns, and exendin-4 treatment in cells pretreated with PA or Tuni significantly reduced the expression of these genes. In addition, relieving ER stress by exendin-4 induced decreased expression of the SEPP1 and fetuin-A genes. Thus, these results ...
Under normal conditions, several calcification inhibitors, including pyrophosphate, adenosine, matrix Gla protein, osteopontin, fetuin-A, osteoprotegerin, and bone morphogenetic protein-7, protect against abnormal mineral deposition in the vessel wall, whereas hypercalcemia, increased levels of parathyroid hormone, inflammatory cytokines, oxidative stress, uremic toxins, advanced glycation end-products, and, most importantly, phosphates induce vascular calcification. During CKD there is an imbalance between inhibitors and inducers of vascular calcification.24 Phosphates increase during CKD because of progressively reduced renal excretion. High phosphate levels may directly induce vascular calcification via the activation of Toll-like receptor 4/NF-κ light-chain enhancer of activated B cells (NF-κB) signaling in VSMCs.25 Moreover, in the presence of high phosphate levels, VSMCs can change their phenotype into osteoblast-like cells via the loss of smooth muscle markers (e.g., α-smooth muscle ...
Calciphylaxis CUA Calciphylaxis Metastatic systemic calcifications after invasive manipulation of animal model No vascular calcifications found CUA Occurs in presence of uremia Abnormalities in divalent ion ie PTH, Ca, PO4 (not required) Vascular calcifications at site of lesions
The gold standard for joint damage in RA is currently the presence of radiological erosions. Management decisions including when to institute aggressive treatment with drugs such as methotrexate and combination regimens are influenced by the presence or absence of erosive change. However, most patients at diagnosis do not have erosions on plain radiography.1 25 There is often a delay of 6 to 12 months before erosions can be confirmed by radiography and during this time the clinician must treat empirically according to clinical indicators of synovitis, which may not accurately predict prognosis.4 26 MRI can reveal erosions as well as synovitis and tendonitis early in RA, giving a detailed picture of joint inflammation and damage.10 11 22 This study of 42 RA patients with recent onset disease (median symptom duration of four months) provides baseline information on MRI changes in the dominant wrist. This is the largest reported study of MRI at this early stage of RA.. We have developed a scoring ...
The most recent Cochrane reviews highlight no benefit in terms of pain relief or physical function from arthroscopic washout or debridement for patients with osteoarthritis of the knee.3 4 Two meta-analyses also suggest no benefit,5 6 with the most recent noting that arthroscopy is not without hazard and that this should be considered in the light of poor efficacy.6 Arthroscopic menisectomy does, however, have a role in specific patients. A recent randomised study in patients with no signs of osteoarthritis on plain radiography but who had persisting medial joint line knee pain despite conservative management found that meniscal resection was beneficial.7 Current guidance from the National Institute for Health and Care Excellence (NICE) suggests that referral for arthroscopic lavage and debridement should not be offered unless the person has a clear history of mechanical locking.1 But in a poll on thebmj.com after the most recent meta-analysis was published, 70% of respondents thought … ...
Radiographic changes associated with Pott disease present relatively late. The following are radiographic changes characteristic of spinal tuberculosis on plain radiography:{ref35} Lytic destruction ... more
Contrary to the general assumption, we found that PPi has bioavailability in humans and mice when administered orally (Fig 1). The observed transient elevation found in healthy volunteers (Fig 1A) indicates that in both GACI and in PXE patients, PPi levels may be transiently raised to the physiological level when 67 or 98 mg Na4PPi/kg of body weight is taken. Importantly, it has been shown that inhibition of calcification in uremic rats and in PXE mice can be achieved by daily intraperitoneal injections of PPi triggering transient increase in plasma PPi levels (ONeill et al, 2011; Pomozi et al, 2017). We determined a t1/2 = 44.7 min what is rather similar to that published in rat (34.1 min; ONeill et al, 2011).. We also demonstrated significant attenuation of calcification in two different well‐characterized mouse models of ectopic calcification disorders, PXE and GACI when the animals were treated with pyrophosphate orally. Furthermore, we demonstrated PPi uptake from the oral cavity and ...
Ectopic calcification as very well as fatty and fibrotic tissues accumulation occurs in skeletal muscle during the disease development of Duchenne buff dystrophy (DMD), a degenerative muscle disorder caused by mutations in the dystrophin gene. the nmMSCs become turned on during the disease development in dKO rodents, exhibiting elevated growth and difference possibilities (adipogenesis, osteogenesis and fibrogenesis). We discovered that after co-culturing the dKO-nmMSCs with dKO-MPCs also, the myogenic difference potential of the dKO-MPCs was decreased. This impact was discovered to end up being possibly mediated by the release of secreted frizzled-related proteins 1 by the dKO-nmMSCs. We posit that the speedy incidence of fibrosis as a result, ectopic calcification and fats deposition, in dKO rodents, is certainly not really just attributable to the speedy exhaustion of the MPC pool, but is certainly also the effect of nmMSC account activation. Outcomes from this research recommend that methods ...
BACKGROUND: In patients with dilated (idiopathic) cardiomyopathy (DCM), little is known about the presence of valvular calcification and its association with hypovitaminosis D, which may predispose affected tissues to calcification. Our objectives were 2-fold: to conduct a retrospective assessment of echocardiographic evidence of valvular calcification in patients with DCM who were known to have hypovitaminosis D (25(OH)D ...
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Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists ... "The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification". J ... Demetriou M, Binkert C, Sukhu B, Tenenbaum HC, Dennis JW (1996). "Fetuin/alpha2-HS glycoprotein is a transforming growth factor ... Fetuin relatives within this superfamily are the histidine-rich glycoprotein (HRG) and kininogen (KNG). The function of Fetuin- ...
ALPHA LIPOIC ACID AS ADD-ON THERAPY TO SUBCUTANEOUS INTERFERON Β-1A FOR RELAPSING-REMITTING MULTIPLE SCLEROSIS: A PILOT STUDY, ... Temelimab or Geneuro GNbAC1 - Monoclonal antibody against the viral The HERV-W envelope glycoprotein, which is supposed to be ... Fetuin-A (alpha-2-HS-glycoprotein) and circulating CD49 expression are emerging biomarkers for the therapeutic efficacy of ... alpha and ERbeta ligand treatment". Proceedings of the National Academy of Sciences of the United States of America. 104 (37): ...
Protein sequencing of Gigantopithecus enamel identified alpha-2-HS-glycoprotein (AHSG), which, in modern apes, is important in ... used the dimensions of gorillas to estimate a femur length of 54.4 cm (1 ft 9 in) and humerus length of 62.7 cm (2 ft 1 in) for ... 36 (2): 141-160. doi:10.30883/jba.v36i2.241. Zhang, Y.; Jin, C.; et al. (2015). "A fourth mandible and associated dental ... 54 (2): 196-204. doi:10.1016/j.jhevol.2007.09.013. PMID 18045651. Ciochon, R.; Piperno, D. R.; Thompson, R. G. (1990). "Opal ...
2006). "Renal osteodystrophy: alpha-Heremans Schmid glycoprotein/fetuin-A, matrix GLA protein serum levels, and bone ... Fetuin-A (alpha-2-HS-glycoprotein) GRCh38: Ensembl release 89: ENSG00000090512 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carbohydrate binding properties of the envelope glycoproteins of human immunodeficiency virus type 1". Glycoconj. J. 9 (6): 315 ... 2004). "Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured ...
Another study on alpha-2-HS-glycoprotein allele frequency showed the Veddas and Sinhalese to be more biologically related to ...
1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and ... "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans". ... Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key acute phase plasma ... 1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for ...
Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes and adipocytes. The AHSG molecule ... 1986). "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein". J. Biol. Chem. 261 (4): 1665- ... 2001). "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene". Ann. Hum. Genet. 65 (Pt 1): 27-34. doi:10.1046/j ... 1983). "Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary ...
"A1BG alpha-1-B glycoprotein". Retrieved May 10, 2013. "EST Profile - Hs.529161". UniGene. National Center for Biotechnology ... Ultimately, alpha-1B glycoprotein seems to be primarily composed of four immunoglobulin domains. The alpha-1-glycoprotein is ... "PREDICTED: alpha-1B-glycoprotein". Retrieved May 10, 2013. "Send to: PREDICTED: alpha-1B-glycoprotein isoform 1 [Pongo abelii ... "PREDICTED: alpha-1B-glycoprotein [Felis catus]". Retrieved May 11, 2013. "PREDICTED: alpha-1B-glycoprotein-like". Retrieved May ...
"MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). " ... "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene ... Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS (Feb 2007). "CITED2 is expressed in human ...
All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the ... Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN (Sep 1989). "A reevaluation of the amino acid sequence of human follitropin ... The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, ... 1999). "Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation". Biochemistry. ...
Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, et al. (July 1994). "Afamin is a new member of the ... Alpha-fetoprotein is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein ... February 2016). "Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin ... Haefliger DN, Moskaitis JE, Schoenberg DR, Wahli W (October 1989). "Amphibian albumins as members of the albumin, alpha- ...
... gangliosidoses Alpha-galactosidase Fabry disease (alpha-galactosidase A) Schindler disease (alpha-galactosidase B) Beta- ... Glycoprotein storage disorders (E77.0-E77.1) Mucolipidoses Also, glycogen storage disease type II (Pompe disease) is a defect ... B deficiency Multiple sulfatase deficiency Mucopolysaccharidoses Type I MPS I Hurler syndrome MPS I S Scheie syndrome MPS I H-S ... glycoproteins (sugar-containing proteins), or so-called mucopolysaccharides. Individually, LSDs occur with incidences of less ...
Bishop DF, Calhoun DH, Bernstein HS, Hantzopoulos P, Quinn M, Desnick RJ (July 1986). "Human alpha-galactosidase A: nucleotide ... This enzyme is a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and ... Two recombinant forms of human alpha-galactosidase are called agalsidase alpha (INN) and agalsidase beta (INN). A mold-derived ... Dean KJ, Sweeley CC (October 1979). "Studies on human liver alpha-galactosidases. I. Purification of alpha-galactosidase A and ...
This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits. PLCB3 has been ... Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). "Regulation of phospholipase C-beta 3 activity by Na+/ ... Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ...
de Koster HS, Kenter MJ, D'Amaro J, et al. (1991). "Positive correlation between oligonucleotide typing and T-cell recognition ... This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It ... analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein ... 1988). "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta ...
Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. CD200R1 is ... Karteris E, Chen J, Randeva HS (April 2004). "Expression of human prepro-orexin and signaling characteristics of orexin ... CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), ... It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons, epithelial ...
Kooter JM, Borst P. Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence ... Heymans HS, Schutgens RB, Tan R, van den Bosch H, Borst P. Severe plasmalogen deficiency in tissues of infants without ... Ouellette M, Hettema E, Wust D, Fase-Fowler F, Borst P. Direct and inverted DNA repeats associated with P-glycoprotein gene ... Boothroyd JC, Cross GA, Hoeijmakers JH, Borst P. A variant surface glycoprotein of Trypanosoma brucei synthesized with a C- ...
2000). "Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by alpha 3 beta 1, alpha 6 beta 1 and alpha ... Smyth N, Vatansever HS, Murray P, et al. (1999). "Absence of basement membranes after targeting the LAMC1 gene results in ... Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They ... Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are ...
Fukuda K, Gupta S, Chen K, Wu C, Qin J (December 2009). "The pseudoactive site of ILK is essential for its binding to alpha- ... Barry FA, Gibbins JM (April 2002). "Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI". The ... Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T ... 433 (2): 113-7. doi:10.1007/s004280050225. PMID 9737788. S2CID 24150231. Tu Y, Li F, Goicoechea S, Wu C (March 1999). "The LIM- ...
Quillen EE, Haslam GC, Samra HS, Amani-Taleshi D, Knight JA, Wyatt DE, Bishop SC, Colvert KK, Richter ML, Kitos PA (July 2006 ... Eckardt K, Schober A, Platzbecker B, Mracek T, Bing C, Trayhurn P, Eckel J (May 2011). "The adipokine zinc-α2-glycoprotein ... impact of a borano group on alpha-P position". Nucleosides Nucleotides Nucleic Acids. 27 (4): 319-31. doi:10.1080/ ... 26 (2): 117-21. doi:10.1055/s-0028-1091393. PMID 18850517. Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, ...
Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, ... Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999). "Evidence of HIV type 1 glycoprotein 120 binding to ... "HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a ... 92 (1-2): 54-9. doi:10.1016/j.physbeh.2007.05.026. PMID 17617428. S2CID 21646700. Kornau HC, Schenker LT, Kennedy MB, Seeburg ...
This is the case for the sugar and lipid moieties in glycoproteins and lipoproteins or RNA in ribosomes. They can be very large ... Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). "A novel coenzyme from bacterial primary alcohol dehydrogenases". Nature ... Bustamante J, Lodge JK, Marcocci L, Tritschler HJ, Packer L, Rihn BH (1998). "Alpha-lipoic acid in liver metabolism and disease ...
"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... The N-terminal domain of the mature protein forms an alpha-helix that constitutes the exposed part of the binding groove, the C ... 1983). "Use of synthetic oligonucleotide probes complementary to genes for human HLA-DR alpha and beta as extension primers for ...
"Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions ... HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit ... The class II protein is a heterodimer consisting of an alpha (DRα) and a beta chain (DRβ), both anchored in the membrane. It ...
Liao F, Shin HS, Rhee SG (1993). "In vitro tyrosine phosphorylation of PLC-gamma 1 & PLC-gamma 2 by src-family protein tyrosine ... Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: ... Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). "Human immunodeficiency virus-1 glycoproteins gp120 and ... Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications ...
Fagerholm SC, Lek HS, Morrison VL (2014). "Kindlin-3 in the immune system". American Journal of Clinical and Experimental ... Kindlin 3 is a cytoskeletal signalling protein involved in the activation of the glycoprotein receptor, integrin. Together with ... Modification of integrin's conformation serves to dissociate alpha and beta subunits by disrupting their interactions and ... Isoform 2 may act as a repressor of NF-kappa-B and apoptosis It has been suggested that the evolutionary source of a single ...
Daugherty MD, Malik HS (August 2014). "How a virus blocks a cellular emergency access lane to the nucleus, STAT!". Cell Host & ... The genome of the Ebola virus was found to encode seven proteins: glycoprotein; nucleoprotein; matrix proteins, VP40 and VP24; ... August 2014). "Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear ... KPNA proteins have 10 armadillo repeats each consisting of three alpha helices which determine their binding specificity, the ...
Human T-cell surface glycoprotein CD8 alpha chain) at the PDBe-KB. Overview of all the structural information available in the ... Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen ... Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha ... The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one ...
Jiang F, Yeo CW, Lee SS, Oh MK, Ghim JL, Shon JH, Kim HS, Kim EY, Kim DH, Shin JG (2013). "Effect of HNF4α genetic polymorphism ... This gene also plays a pivotal role in the expression and synthesis of SHBG, an important glycoprotein made primarily in the ... "Entrez Gene: HNF4A hepatocyte nuclear factor 4, alpha". Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan ... Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear ...
Shapiro HS, Chen J, Wrana JL, Zhang Q, Blum M, Sodek J (November 1993). "Characterization of porcine bone sialoprotein: primary ... Williams PA, Peacocke AR (November 1965). "The physical properties of a glycoprotein from bovine cortical bone (bone ... 280 (2): 460-5. doi:10.1006/bbrc.2000.4146. PMID 11162539. Tye CE, Rattray KR, Warner KJ, Gordon JA, Sodek J, Hunter GK, ... 43 (2): 127-35. doi:10.1111/j.1600-0765.2007.01014.x. PMID 18302613. Human IBSP genome location and IBSP gene details page in ...
Oikonomakos NG, Kontou M, Zographos SE, Tsitoura HS, Johnson LN, Watson KA, Mitchell EP, Fleet GW, Son JC, Bichard CJ, et al. ( ... catalyzes the rate-limiting step in glycogenolysis in animals by releasing glucose-1-phosphate from the terminal alpha-1,4- ... doi:10.1007/s11910-007-0026-2. PMID 17217859.. *^ Andreu AL, Nogales-Gadea G, Cassandrini D, Arenas J, Bruno C (July 2007). " ... Moller DE (Dec 2001). "New drug targets for type 2 diabetes and the metabolic syndrome". Nature. 414 (6865): 821-7. doi:10.1038 ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ... Barres BA, Hart IK, Coles HS, Burne JF, Voyvodic JT, Richardson WD, Raff MC (1992). "Cell Death and Control of Cell Survival in ... Though PDGF is synthesized,[3] stored (in the alpha granules of platelets),[4] and released by platelets upon activation, it is ...
Drotrecogin alpha (activated) belongs to the class of serine proteases. Drotrecogin alfa has not been found to improve outcomes ... Warren HS, Suffredini AF, Eichacker PQ, Munford RS (September 2002). "Risks and benefits of activated protein C treatment for ... Because drotrecogin-alpha is a therapeutic protein, there exists a potential for immunogenicity. Antibodies against drotrecogin ... The following patients are at an increased risk for bleeding complications due to drotrecogin-alpha therapy, and a careful risk ...
Not to be confused with glycopeptide, proteoglycan, or glycoprotein.. Peptidoglycan, also known as murein, is a polymer ... Also in this reaction, the C3 hydroxyl group will remove a phosphate from the alpha carbon of phosphoenolpyruvate. This creates ... 2] In Gram-positive strains, it is important in attachment roles and serotyping purposes.[3] For both Gram-positive and Gram- ... 2,4). (When UDP is used as an energy source, it gives off an inorganic phosphate.) This initial stage, is used to create the ...
Recently, direct measurement of vinblastine binding to permease-glycoprotein (P-glycoprotein) in the presence of ... Dong J, Yang G, McHaourab HS (May 2005). "Structural basis of energy transduction in the transport cycle of MsbA". Science. 308 ... The T domains are each built of typically 10 membrane spanning alpha helices, through which the transported substance can cross ... P-glycoprotein is the best-studied efflux pump and as such has offered important insights into the mechanism of bacterial pumps ...
Kim SS, Kim SH, Kang HS, Chung HY, Choi I, Cheon YP, Lee KH, Lee DM, Park J, Lee SY, Chun T (Jan 2010). "Molecular cloning and ... March 1, 1999). "Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and ... Workman CJ, Rice DS, Dugger KJ, Kurschner C, Vignali DA (Aug 2002). "Phenotypic analysis of the murine CD4-related glycoprotein ... 6 (2): 145-52. doi:10.1038/sj.gene.6364171. PMID 15674389.. *^ Lundmark F, Harbo HF, Celius EG, Saarela J, Datta P, Oturai A, ...
Perez-Vilar J, Hill RL (2004). "Mucin Family of Glycoproteins". Encyclopedia of Biological Chemistry (Lennarz & Lane, EDs.). ... HS. *Syndecan 1. Other. *Activin and inhibin. *ADAM. *Alpha 1-antichymotrypsin. *Apolipoprotein H ... 2: 758-764.. *^ Norman PJ, Norberg SJ, Guethlein LA, Nemat-Gorgani N, Royce T, Wroblewski EE, Dunn T, Mann T, Alicata C, ... 2] calcification in echinoderms[3] and bone formation in vertebrates.[4] They bind to pathogens as part of the immune system. ...
August 2005). "Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute ... Véxase HS Véxase MM UniProt. Q9BYF1 Q8R0I0 RefSeq. (ARNm). NM_021804 NM_001130513 ... SARS-CoV-2. Ligazóns externas[editar , editar a fonte]. *Localización no xenoma humano de ACE2 e páxina con detalles sobre o ... O ACE2 (do inglés angiotensin converting enzyme 2 ou enzima convertedor da anxiotensina 2)[1] é un enzima unido á superficie ...
1989). "Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine- ... Chung HS; et al. (2013). "Cysteine Oxidative Posttranslational Modifications: Emerging Regulation in the Cardiovascular System" ... or tryptophan resulting in a glycoprotein. Distinct from glycation, which is regarded as a nonenzymatic attachment of sugars. * ... Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha". J. Biol. Chem. 264 (24): 14334-41. ...
Min HS, Kim JE, Lee MH, Song HK, Kang YS, Lee MJ, Lee JE, Kim HW, Cha JJ, Chung YY, Hyun YY, Han JY, Cha DR (Jun 2014). " ... It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of ... 2oph: Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor ... 14 (2): 98-107. doi:10.1097/MED.0b013e3280a02f65. PMID 17940427.. *^ Raj VS, Mou H, Smits SL, Dekkers DH, Müller MA, Dijkman R ...
Stanley WM, Loring HS. The isolation of crystalline tobacco mosaic virus protein from diseased tomato plants. Science. 1936;83( ... Transport of viral proteins to the apical membranes and interaction of matrix protein with glycoproteins in the assembly of ... Safety, tolerability and efficacy of peginterferon alpha-2a and ribavirin in chronic hepatitis C in clinical practice: The ... 2008;123(2):247-50. doi:10.1002/ijc.23620. PMID 18449881.. *^ Molecular Biology of the Cell; Fourth Edition. New York and ...
Not to be confused with peptidoglycan, glycoprotein, or glycopeptide.. Aggrecan, the major proteoglycan in cartilage, has 2316 ... HS. *Syndecan 1. Other. *Activin and inhibin. *ADAM. *Alpha 1-antichymotrypsin. *Apolipoprotein H ... 2] The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through a tetrasaccharide bridge ...
Heparan sulfate (HS) is a linear polysaccharide found in all animal tissues. It occurs as a proteoglycan (PG) in which two or ... Fibronectins are glycoproteins that connect cells with collagen fibers in the ECM, allowing cells to move through the ECM. ... three HS chains are attached in close proximity to cell surface or ECM proteins.[10][11] It is in this form that HS binds to a ... The cell wall comprises multiple laminate layers of cellulose microfibrils embedded in a matrix of glycoproteins, including ...
IL-17(A) is a 155-amino acid protein that is a disulfide-linked, homodimeric, secreted glycoprotein with a molecular mass of 35 ... Mudigonda P, Mudigonda T, Feneran AN, Alamdari HS, Sandoval L, Feldman SR (2012). "Interleukin-23 and interleukin-17: ... Cytokines released from DCs stimulate dying keratinocytes to secrete TNF-alpha, IL-1 and IL-6 leading to the chemotaxis of T ... 2 (6): 453-5. doi:10.1093/oxfordjournals.humrep.a136569. PMID 3312283.. *^ "FDA approves new psoriasis drug Cosentyx". U.S. ...
... or alpha-1-acid glycoprotein (α1AGp,[1] AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five- ... "pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)". The Biochemical Journal. 280 ( Pt 1) (1): ...
To enter B cells, viral glycoprotein gp350 binds to cellular receptor CD21 (also known as CR2).[26] Then, viral glycoprotein ... Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova N, Klichinsky M, et al. (August 2012). "An atlas of the Epstein-Barr virus ... The Epstein-Barr virus has been implicated in disorders related to alpha-synuclein aggregation (e.g. Parkinson's disease, ... The viral three-part glycoprotein complexes of gHgL gp42 mediate B cell membrane fusion; although the two-part complexes of ...
Alpha-fetoprotein. *Erythropoietin (EPO). Functions[edit]. Some functions served by glycoproteins[5]:524 Function Glycoproteins ... Glycoproteins are important for white blood cell recognition.[citation needed] Examples of glycoproteins in the immune system ... Some important methods used to study glycoproteins Method Use Periodic acid-Schiff stain Detects glycoproteins as pink bands ... Monosaccharides commonly found in eukaryotic glycoproteins include:[5]:526 The principal sugars found in human glycoproteins[6] ...
Senior AE, al-Shawi MK, Urbatsch IL (1995). „The catalytic cycle of P-glycoprotein". FEBS Lett. 377 (3): 285-9. PMID 8549739. ... Dong J, Yang G, McHaourab HS (2005). „Structural basis of energy transduction in the transport cycle of MsbA". Science. 308 ( ... a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes". Genomics. 53 (2): 137 ... Geisler M, Murphy AS (2006). „The ABC of auxin transport: the role of p-glycoproteins in plant development". FEBS Lett. 580 (4 ...
... a conserved alpha helix rod, a variable non alpha helix head, and a carboxy-terminal tail.[12] Desmin, as all intermediate ... Goldfarb LG, Park KY, Cervenáková L, Gorokhova S, Lee HS, Vasconcelos O, Nagle JW, Semino-Mora C, Sivakumar K, Dalakas MC ( ... Bennardini F, Wrzosek A, Chiesi M (August 1992). "Alpha B-crystallin in cardiac tissue. Association with actin and desmin ... 6 (2): 288-293. doi:10.1002/mgg3.358. PMC 5902401. PMID 29274115.. *^ Saha K, Saha A, Datta C, Chatterjee U, Ray S, Bera M. ...
Interferon alpha (interferon alfa, IFN-α). *Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, ... 4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.[1 ...
Human Immunodeficiency Virus Glycoprotein 120. *Human CD4 genome location and CD4 gene details page in the UCSC Genome Browser. ... Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen ... Interleukin 14 (taxilin alpha, HMW-BCGF). *Interleukin 16 (signals through CD4). *Interleukin 24 (signals through IL-22Rα1/IL- ... In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T ...
The CD44 antigen is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. In humans, the ... HS. *Syndecan 1. Other. *Activin and inhibin. *ADAM. *Alpha 1-antichymotrypsin. *Apolipoprotein H ... "The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is ... 20 (2): 337-9. doi:10.1096/fj.05-4574fje. PMID 16352650.. *^ a b Napier SL, Healy ZR, Schnaar RL, Konstantopoulos K (Feb 2007 ...
Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ (1996). "Ex-vivo expansion of murine marrow cells with IL-3, Il-6, Il-11 and ... Ihle JN, Pepersack L, Rebar L (June 1981). "Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid ... Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S (1995). "HIV-1 envelope glycoproteins induce ... induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but ...
GAGAL promotes the alpha helicity of lacritin's C-terminal amphipathic alpha helix and likely binds to the hydrophobic face. ... "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6 ... Koo BS, Lee DY, Ha HS, Kim JC, Kim CW (2005). "Comparative analysis of the tear protein expression in blepharitis patients ... Lacritin is a glycoprotein of the human tear film, and to a lesser extent of saliva, lung lavage and plasma. It is mainly ...
Roehm PC, Shekarabi M, Wollebo HS, Bellizzi A, He L, Salkind J, Khalili K (April 2016). "Inhibition of HSV-1 Replication by ... A study from the Albert Einstein College of Medicine, where glycoprotein D (gD-2) was deleted from the herpes cell, showed ... "The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion". PLOS Pathogens. 13 ( ... Aubert M, Madden EA, Loprieno M, DeSilva Feelixge HS, Stensland L, Huang ML, Greninger AL, Roychoudhury P, Niyonzima N, Nguyen ...
Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes and adipocytes. The AHSG molecule ... 1986). "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein". J. Biol. Chem. 261 (4): 1665- ... 2001). "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene". Ann. Hum. Genet. 65 (Pt 1): 27-34. doi:10.1046/j ... 1983). "Characterization of the B-chain of human plasma alpha 2HS-glycoprotein. The complete amino acid sequence and primary ...
Abcams Alpha 2 HS Glycoprotein ELISA Kit suitable for Cell culture supernatant, Milk, Urine, Serum, Plasma, Cerebral Spinal ...
"Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.". Osawa M., Yuasa I., Kitano T., Henke J., Kaneko M., ... "Haplotype analysis of the human alpha2-HS glycoprotein (fetuin) gene.". Osawa M., Yuasa I., Kitano T., Henke J., Kaneko M., ... "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein.". Yoshioka Y., Gejyo F., Marti T., ... "The complete amino acid sequence of the A-chain of human plasma alpha 2HS-glycoprotein.". Yoshioka Y., Gejyo F., Marti T., ...
Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum antibodies FETB11-S ... Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum antibodies FETB11-S Anti-Bovine Fetuin ( ... Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum. Catalog#. Product Description. Product Type. Antibody Type ... Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum. antibodies. 100 ul. $325.00 ...
Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG Primary Antibodies FETA14-M ... Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG Primary Antibodies FETA14-M Monoclonal Anti-Mouse Fetuin A ( ... Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG. Primary Antibodies. Mono-Rat. 100 ug. $355.00 ... Alpha Diagnostic Intl. Inc., 6203 Woodlake Center , San Antonio, Texas 78244 USA. Toll Free: (800)-786-5777 , 210-561-9515 , ...
"alpha-2-HS-Glycoprotein" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "alpha-2-HS-Glycoprotein" by people in this website by year, ... Below are the most recent publications written about "alpha-2-HS-Glycoprotein" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "alpha-2-HS-Glycoprotein". ...
AHSG2; alpha-2-HS-glycoprotein 2; fb60d10; wu:fb60d10; si:cu104710.4; si:ch73-252g14.4 ...
ELISA Kit can measure Bovine Alpha-2-HS-glycoprotein in serum, blood, plasma, cell culture supernatant and other related ... Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit. (No reviews yet) Write a ... ELISA Genie Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit. The ELISA Genie Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit ... Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 ...
Rat Ahsg(Alpha-2-HS-glycoprotein) ELISA Kit. $410.00. This item is made to order and will take 10-12 business days to ... Home / Quantitative Biomarker Assays / Rat / Rat Ahsg(Alpha-2-HS-glycoprotein) ELISA Kit. ... Download our SARS-CoV-2 COVID-19 Protein Plate White PaperRead More ...
Alpha 2-HS Glycoprotein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... HS-glycoprotein,alpha-2-,inhibitor of the insulin-receptor tyrosine kinase,pp63 (cystatin superfamily) *AHSG ... Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG). (PMID: 9322749) Osawa M … Takeichi S (Gene 1997) 2 3 4 22 ... Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. The two chains A and B are ...
Marked defects in the expression and glycosylation of alpha2-HS glycoprotein/fetuin-a in plasma from neonates with intrauterine ... AHSG: alpha-2-HS glycoprotein; ALB: albumin; APOA1: apolipoprotein A1; TF: transferrin Least squares means sharing a common ... The abundance of Rho GDP-dissociation inhibitor alpha (ARHGDIA) was reduced for 110-day-old fetuses compared with 90-day-old ... Laborda J, Naval J, Calvo M, Lampreave F, Uriel J. Alpha-fetoprotein and albumin uptake by mouse tissues during development. ...
Glycoproteins * Nitriles * Tyrphostins * alpha-2-HS-Glycoprotein * tyrphostin AG825 * Insulin-Like Growth Factor I ...
Alpha 1 Acid Glycoprotein, Human Plasma. Catalog #: 7547 , Datasheet Starting at: $125.00 ...
Type 2 indicating that the following substances may be helpful: Magnesium, Cinnamon, and Arginine ... Serum alpha-2-HS glycoprotein was reduced in rats treated with standardized E. longifolia extract.Dec 31, 2014. ... 1 Abstracts with Diabetes Mellitus: Type 2 & Tongkat Ali Research. [x] Remove Focus on Tongkat Ali. Filter by Study Type. ... Ginger has been studied to have value in over 150 health conditions with type 2 diabetes top of the list. With anti-diabetic ...
... alpha2-HS glycoprotein , Alpha-2-HS-glycoprotein ... Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the ... Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists ... glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , fetuin , alpha-2-HS glycoprotein , pre-pro polypeptide (AA -18 to -346 ... Synonym: alpha-2-HS-glycoprotein 1 AHSG Reactivity: Human AA 19-367 Colorimetric Sandwich ELISA 312-20000 pg/mL Cell Culture ...
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells. ... Alpha 2-HS glycoprotein (fetuin-A) modulates murine skin tumorigenesis.. Leite-Browning ML, McCawley LJ, Jahnen-Dechent W, King ...
Alpha 2HS glycoprotein. *Alpha-2-HS-glycoprotein chain B. *Alpha-2-Z-globulin ...
alpha-2-HS-glycoprotein [Source:HGNC Symbol;Acc:349]. Mouse Orthologue:. Ahsg. Mouse Description:. alpha-2-HS-glycoprotein Gene ... 2. 10136396. KASP Assay ID:. None (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. None. Flanking ... 2. 10134635. KASP Assay ID:. None (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. ... 2. 10136046. KASP Assay ID:. 554-1793.1 (used for ordering genotyping assays from LGC Genomics). KASP Sequence:. ...
alpha-2-HS-glycoprotein [Source:HGNC Symbol;Acc:349]. Mouse Orthologue:. Ahsg. Mouse Description:. alpha-2-HS-glycoprotein Gene ... alpha-2-HS-glycoprotein [Source:RefSeq peptide;Acc:NP_997787]. Human Orthologue:. AHSG. Human Description:. ...
Anti-alpha-2-HS-glycoprotein; find Sigma-Aldrich-WH0000197M1 MSDS, related peer-reviewed papers, technical documents, similar ... Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists ... alpha-. 2-. HS-. glycoprotein, Anti-AHS, Anti-FETUA, Anti-HSGA * NACRES NA.41 ... The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more .... ...
Hs; negative regulation of growth; UniGene Build:. Hs.234/Mm.193. [Text]. [Clones]. ... Glycoprotein hormones, alpha polypeptide. NM_001252383. NM_000735. Gene Info. CGREF1. Cell growth regulator with EF-hand domain ... Glycogen synthase kinase 3 alpha. NM_019884. Gene Info. HIF1A. Hypoxia inducible factor 1, alpha subunit (basic helix-loop- ... Crystallin, alpha B. NM_001885. Gene Info. CTH. Cystathionase (cystathionine gamma-lyase). NM_001902. NM_001190463. NM_153742. ...
Hs.234/Mm.193. [Text]. [Clones]. Displaying 1 thru 300 of 1752 items Go to page: 1 2 3 4 5 6 ... Glycoprotein hormones, alpha polypeptide. NM_001252383. NM_000735. Gene Info. CGN. Cingulin. NM_020770. Gene Info. ... Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase). NM_ ... ATPase, Cu++ transporting, alpha polypeptide. NM_000052. Gene Info. ATXN3. Ataxin 3. NM_004993. NM_001127696. NM_001127697. NM_ ...
... alpha-2-HS-Glycoprotein; alpha-2-HS-Glycoprotein: analysis ...
Oh TJ, Yu JM, Min KW, Son HS, Lee MK, Yoon KH, Song YD, Park JY, Jeong IK, Cha BS, Kim YS, Baik SH, Kim IJ, Kim DM, Kim SR, Lee ... Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. ... Chung HS, Lee HJ, Hwang SY, Choi JH, Yoo HJ, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH, Choi KM. ... Chung HS, Hwang SY, Choi JH, Lee HJ, Kim NH, Yoo HJ, Seo JA, Kim SG, Kim NH, Baik SH, Choi KM. ...
In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel ... In addition, we hypothesize that the expression of alpha-2-HS-glycoprotein, which has not been previously observed in enamel ... Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles ... 2 Excavations in Chuifeng Cave.. a, Main entrance of Chuifeng Cave. b, Well-preserved deposits before excavation. c, The ...
Alpha-2-HS-glycoprotein (P02765) (SMART). OMIM:138680: ALPHA-2-HS-GLYCOPROTEIN; AHSG. ... However, some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. ... Crystal structure of histidine-rich glycoprotein N2 domain reveals redox activity at an interdomain disulfide bridge: ...
Alpha2-HS glycoprotein (AHSG) a glycoprotein present in the serum is synthesized by hepatocytes. The AHSG molecule consists of ... alpha-2-HS-glycoprotein Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dHsaEG5017746 Info: EG; Same primer ... alpha-2-HS-glycoprotein Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5049848 Info: FAM; Same primer ... alpha-2-HS-glycoprotein Assay Type: Probe Application: Gene Expression Unique Assay ID: dHsaCPE5049849 Info: HEX; Same primer ...
Alpha-2-HS-glycoprotein precursor Aliases:. Not Available. RefSeq:. NM_012898. Ensembl:. ENSRNOG00000038370 ...
Genetic polymorphisms of orosomucoid and alpha-2-HS-glycoprotein in Thai, Sri Lankan and Paraguayan populations *Kazuo Umetsu ... Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus *Aritoshi Iida ... Rights & permissionsfor article Genetic polymorphisms of orosomucoid and alpha-2-HS-glycoprotein in Thai, Sri Lankan and ... Rights & permissionsfor article Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus ...
  • The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA) is one of the hepatokines and is known to be associated with insulin resistance and type 2 diabetes. (readbyqxmd.com)
  • Human fetuin is synonymous with α2-HS-glycoprotein (genetic symbol AHSG), α2-HS, A2HS, AHS, HSGA, and fetuin-A. Fetuin-A exists as a single-copy gene in the human and mouse genomes. (wikipedia.org)
  • alpha-2-HS-glycoprotein (AHSG, Alpha-2-Heremans-Schmid Glycoprotein) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. (wikipedia.org)
  • The only peak that satisfied this condition corresponded to the B-chain of [[alpha].sub.2]-Heremans-Schmid glycoprotein ( AHSG , fetuin-A). (thefreedictionary.com)
  • Fetuin-A, also known as α2-Heremans-Schmid glycoprotein (AHSG), is a circulating negative acute-phase glycoprotein with 62-kDa molecular weight [ 6 ]. (alliedacademies.org)
  • α-2-Heremans-Schmid Glycoprotein (AHSG), which is required for macrophage deactivation by endogenous cations, is associated with inflammatory regulation. (cdc.gov)
  • antibodies-Anti-Bovine Fetuin (Alpha-2 HS-Glycoprotein, AHSG, A2HS) antiserum-Genemed Synthesis Inc. (genemedsyn.com)
  • Primary Antibodies-Monoclonal Anti-Mouse Fetuin A (Alpha-2 HS-Glycoprotein, AHSG, A2HS) IgG-Alpha Diagnostic International Inc. (4adi.com)
  • Alpha2-HS glycoprotein, a glycoprotein present in the serum, is synthesized by hepatocytes and adipocytes. (wikipedia.org)
  • The ELISA Genie Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit can assay for Bovine Alpha-2-HS-glycoprotein in the following samples: serum, blood, plasma, cell culture supernatant and other related supernatants and tissues. (elisagenie.com)
  • The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. (genecards.org)
  • Serum alpha-2-HS glycoprotein was reduced in rats treated with standardized E. longifolia extract. (greenmedinfo.com)
  • Association of [alpha]2-HS glycoprotein ( AHSG , fetuin-A) polymorphism with AHSG and phosphate serum levels. (thefreedictionary.com)
  • To illustrate the clinical potential of AHSG to predict survival in GBM patients, we combined patient age and Karnofsky score, the 2 most widely used prognostic factors (2-4), with serum AHSG into a simple 3-point score. (thefreedictionary.com)
  • Serum protein profiles were analyzed by 2-dimensional electrophoresis, and altered proteins were identified via mass spectrometry. (usm.my)
  • We observed that alpha-2-HS glycoprotein (AHS) was significantly decreased in the serum of experimentally treated rats compared to pre-treated animals. (usm.my)
  • Neuron-specific enolase (NSE) was determined in serum from 110 patients with testicular cancer and compared to the established tumor markers alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG). (springer.com)
  • The amount of bound Bovine Alpha-2-HS-glycoprotein is proportional to the signal generated by the reaction meaning the Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kit assay gives you a quantitative measurement of the analyte in your samples. (elisagenie.com)
  • context" : "http://schema.org", "@type" : "Product", "name" : " Mouse Alpha-2-HS-glycoprotein (Ahsg) ELISA Kit", "image" : "https://www.elisagenie. (elisagenie.com)
  • context" : "http://schema.org", "@type" : "Product", "name" : " Bovine Alpha-lactalbumin (LALBA) ELISA Kit", "image" : "https://www.elisagenie. (elisagenie.com)
  • Alpha-2-HS glycoprotein derives from this precursor, when the connecting peptide is cleaved off. (mybiosource.com)
  • A physiological role for alpha2-HS glycoprotein: stimulation of macrophage uptake of apoptotic cells. (uniprot.org)
  • In this study, we explored the relationship between the alpha2-HS glycoprotein (AHSG) gene and bone size variation at the spine and hip in a Chinese population. (hku.hk)
  • In particular the role of IL-6 on gene expression and production of a glycoprotein, fetuin-A produced by hepatocytes, was investigated by culturing hepatocytes in the membrane bioreactor, both in the absence and presence of IL-6 (300 pg/ml). (elsevier.com)
  • Sheep anti Bovine asialofetuin antibody recognizes bovine Alpha-2-HS-glycoprotein, also known as asialofetuin or fetuin-A. Asialofetuin is a 359 amino acid ~55kDa secreted glycoprotein containing two cystatin fetuin-A-type domains. (mybiosource.com)
  • Time-course differences in adipose tissue protein abundance were revealed between fetal genotypes for a few secreted proteins participating in responses to organic substances, such as alpha-2-HS-glycoprotein, transferrin and albumin. (springer.com)
  • However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains. (embl-heidelberg.de)
  • It can be viewed as modified ultrafiltrate of plasma combined with proteins derived from kidney and urinary tract, with protein concentration approximately 1000-fold lower than in plasma itself [ 2 ]. (hindawi.com)
  • Three out of nine proteins identified to associate with HDL-4-Apo A-2 are involved in the regulation of fibrinolysis, namely, the plasmin regulator, alpha-2-antiplasmin, and two major components of the kallikrein-kinin pathway (coagulation factor XI and prekallikrein), and their physical presence in the HDL-4 subfraction was confirmed. (bmj.com)
  • Bone matrix, proteins such as Alpha 2 HS glycoprotein, osteonectin, and Type 1 collagen are chemotatic factors for monocytes and macrophages (Malone et al, J. Cell Bio. (google.com)
  • Fetuin A, also called Heramans Schmid alpha 2 glycoprotein (AHSG), is one of the important proteins that inhibit vascular calcification. (alliedacademies.org)
  • We found collagen that forms the core of the bone tissue along with other protein varieties, such as albumin, lumican, osteoglycine, and alpha-2-HS-glycoprotein, that regulate various processes in the body. (mipt.ru)
  • Contains 2 cystatin fetuin-A-type domains. (abcam.com)
  • Fetuin A/AHSG is a human plasma glycoprotein belonging to the Cystatin family of protease inhibitors. (biovendor.com)
  • Compare results from immunehistology with data of liquid samples screened in an ELISA with the same antibody, MoAb 2 from Biosensis. (artimmun.de)
  • Posttranslational processing of human alpha 2-HS glycoprotein (human fetuin). (wikipedia.org)
  • The large number of genome-wide association studies (GWAS) performed have resulted in the identification of hundreds of SNPs that are associated with human traits and diseases ( 1 , 2 ). (pnas.org)
  • Biosensis human, mouse and rat ELISAs for soluble antigen monitoring are available in 2 sizes, 1x96 and 2x96 wells. (artimmun.de)
  • Structure of the N- and O-glycans of the A-chain of human plasma alpha 2HS-glycoprotein as deduced from the chemical compositions of the derivatives prepared by stepwise degradation with exoglycosidases. (expasy.org)
  • Previously, we reported that a 59 kDa bone sialoprotein purified from rat mandible, is the rat counterpart of human alpha_2-HS glycoprotein and bovine fetuin. (nii.ac.jp)
  • DeBruijn HA, Sleijfer DT, Koops HS, Suurmeijer AJH, Marrink J, Ockhuizen T (1985) Significance of human chorionic gonadotropin, alpha-fetoprotein, and pregnancy-specific beta-1-glycoprotein in the detection of tumor relapse and partial remission in 126 patients with nonsemi-nomatous testicular germ cell tumors. (springer.com)
  • Only a few biomarkers (such as HER-2/neu, estrogen receptor, and progesterone receptor) have utility for diagnosis and prognosis. (hindawi.com)
  • Fetuin relatives within this superfamily are the histidine-rich glycoprotein (HRG) and kininogen (KNG). (wikipedia.org)
  • How do our Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kits work? (elisagenie.com)
  • The ELISA Genie Bovine Alpha-2-HS-glycoprotein (AHSG) ELISA Kits are designed for the quantitative measurement of analytes in a wide variety of samples. (elisagenie.com)
  • 2,3 Although vascular calcification was once considered only a passive process of dead and dying cells, work from laboratories worldwide has now highlighted that arterial biomineralization is an actively regulated form of calcified tissue metabolism. (ahajournals.org)
  • A significant upregulation of Osteoactivin, a gene related to bone mineralization, was found in aged rats (both control and task), while alpha-2-HS-glycoprotein was significantly down-regulated in young adult 3 week HRLF task rats only. (cdc.gov)
  • 10 Furthermore, we highlight differences between the low-density lipoprotein receptor (LDLR)-deficient and apolipoprotein E (apoE)-deficient murine models ( Table 2 ) that help articulate the multifaceted contributions of dyslipidemia, diabetes mellitus, and uremia to arterial calcium deposition. (ahajournals.org)
  • The standard treatment confers the patients a median overall survival time of 15 months [ 2 ], due to tumor cells that survive initial chemo- and radiotherapy causing tumor regrowth/recurrence. (oncotarget.com)
  • Alpha-gal is predominantly found in the tissues of non-primate mammalian organisms. (etsu.edu)
  • The linkage disequilibrium (LD) maps of these two genes were built with Haploview using data on CHB+JPT (version 2) from the HapMap. (cdc.gov)
  • The calcification became drastically exacerbated when the fetuin-A knockout was combined with the genetic background DBA/2. (wikipedia.org)
  • 1 , 2 Since that time, much genetic research has been undertaken in both plants and animals. (dovepress.com)
  • F. Ferstl, H. H. Hoppe (1986) 'Alpha-l-Antitrypsine (Pi) Polymorphism. (isfg.org)
  • Danish hospital researchers have proven that the typical recommendation among conventional doctors and nutritionists to type 2 diabetics to lay off the fruit is quite simply wrong. (greenmedinfo.com)
  • New research from the West Virginia University School of Medicine has confirmed other research finding that Bisphenol A (BPA) - found among various plastics and resins in consumer goods - may lead or contribute to both type 1 and type 2 diabetes. (greenmedinfo.com)
  • The research is quite clear - oral medications to treat type 2 diabetes do not alter the long-term progression of the disease. (greenmedinfo.com)
  • Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial. (nih.gov)
  • Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Patients. (nih.gov)
  • Its role in the pathogenesis of type 2 diabetes (T2DM) has also been discussed. (springermedizin.de)
  • Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. (springermedizin.de)
  • However, the longitudinal association of fetuin-A with incident type 2 diabetes mellitus is unknown. (nih.gov)
  • alpha-2-HS-Glycoprotein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • The small HDL subclass rich in apolipoprotein A-2 content (HDL-4-Apo A-2) exhibited the most significant association with survival. (bmj.com)
  • Following early detection, radiation therapy, chemotherapy (before or after surgery), and hormone therapy (tamoxifen [ 2 ] and aromatase inhibitors [ 3 - 5 ]) also have utility for therapeutic intervention. (hindawi.com)
  • and 3) task performance in aged rats only (corticotropin releasing hormone, interleukin 4, interferon regulatory factor 1, inhibin alpha, and interleukin 6). (cdc.gov)
  • Due to the fact that both the hypersensitivity reaction and the peak of lipoproteins in circulation occur ~5 hours postprandial, we hypothesize that the alpha-gal molecules are transported via intestinal lipoproteins. (etsu.edu)
  • 2,4,11 We end by summarizing the importance of considering these disease stage- and context-specific contributions arterial mineralization when crafting therapeutic strategies to address the disease burden of vascular calcification that increasingly afflicts our patients. (ahajournals.org)
  • 28-32 In this section, we review this new data and also highlight distinctions between the LDLR −/− and apoE −/− murine disease models 33 ( Table 2 ) that provide insights into the mechanistic complexities of inflammation-dependent arterial calcium accumulation. (ahajournals.org)
  • Alopecia-Intellectual Disability Syndrome, also known as alopecia intellectual disbility syndrome 1 , is related to alopecia intellectual disability syndrome 2 and alopecia-mental retardation syndrome 1 , and has symptoms including seizures An important gene associated with Alopecia-Intellectual Disability Syndrome is AHSG (Alpha 2-HS Glycoprotein). (malacards.org)