AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
alpha-2-AntiplasminFibrinolysinFibrinolysisPlasminogenHemorrhagic DisordersAntifibrinolytic AgentsFibrinFactor XIIIaalpha-MacroglobulinsTissue Plasminogen ActivatorBlood CoagulationPlasminogen ActivatorsCarboxypeptidase UFibrinogenHemostasisStreptokinaseUrokinase-Type Plasminogen ActivatorComplement C1 Inactivator ProteinsFibrin Fibrinogen Degradation ProductsAminocaproic AcidPlasminogen Inactivatorsalpha 1-AntitrypsinAprotininAntithrombin IIIFactor XIIIImmunoelectrophoresis, Two-DimensionalCorneal PerforationKringlesPlasminogen Activator Inhibitor 1KineticsSerine Proteinase InhibitorsFactor XIIReceptors, Adrenergic, alphaBlood Coagulation FactorsMolecular Sequence DataRecombinant ProteinsHypoxia-Inducible Factor 1, alpha SubunitAmino Acid SequenceFibrinolytic AgentsBlood Coagulation TestsDictionaries, MedicalDictionaries as TopicSerpinsAntibodies, MonoclonalAntibodiesAntibody SpecificityCost ControlForecastingDrug CostsUnited StatesPigment Epithelium of EyeRetinal Pigment EpitheliumProtease InhibitorsOsteogenesis Imperfecta
alpha-2-Antiplasmin
A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.
Fibrinolysin
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Fibrinolysis
The natural enzymatic dissolution of FIBRIN.
Plasminogen
Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.
Hemorrhagic Disorders
Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
Antifibrinolytic Agents
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
Fibrin
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
Factor XIIIa
Activated form of FACTOR XIII, a transglutaminase, which stabilizes the formation of the fibrin polymer (clot) culminating the blood coagulation cascade.
alpha-Macroglobulins
Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.
Tissue Plasminogen Activator
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Blood Coagulation
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Plasminogen Activators
A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation.
Carboxypeptidase U
A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Hemostasis
The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.
Streptokinase
Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linkages and serves as an activator of plasminogen. It is used in thrombolytic therapy and is used also in mixtures with streptodornase (STREPTODORNASE AND STREPTOKINASE). EC 3.4.-.
Urokinase-Type Plasminogen Activator
A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is between ARGININE and VALINE. It was isolated originally from human URINE, but is found in most tissues of most VERTEBRATES.
Complement C1 Inactivator Proteins
Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits.
Fibrin Fibrinogen Degradation Products
Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.
Aminocaproic Acid
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
Plasminogen Inactivators
Important modulators of the activity of plasminogen activators. The inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.
alpha 1-Antitrypsin
Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
Aprotinin
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
Antithrombin III
A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.
Factor XIII
A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.
Immunoelectrophoresis, Two-Dimensional
Immunoelectrophoresis in which a second electrophoretic transport is performed on the initially separated antigen fragments into an antibody-containing medium in a direction perpendicular to the first electrophoresis.
Corneal Perforation
A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.
Kringles
Triple-looped protein domains linked by disulfide bonds. These common structural domains, so-named for their resemblance to Danish pastries known as kringlers, play a role in binding membranes, proteins, and phospholipids as well as in regulating proteolysis. Kringles are also present in coagulation-related and fibrinolytic proteins and other plasma proteinases.
Plasminogen Activator Inhibitor 1
A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.
Kinetics
The rate dynamics in chemical or physical systems.
Serine Proteinase Inhibitors
Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.
Factor XII
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Receptors, Adrenergic, alpha
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Blood Coagulation Factors
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Fibrinolytic Agents
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.
Blood Coagulation Tests
Laboratory tests for evaluating the individual's clotting mechanism.
Dictionaries, Medical
Dictionaries as Topic
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Serpins
A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Antibodies
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Antibody Specificity
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Cost Control
The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed)
Forecasting
The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.
Drug Costs
The amount that a health care institution or organization pays for its drugs. It is one component of the final price that is charged to the consumer (FEES, PHARMACEUTICAL or PRESCRIPTION FEES).
United States
Pigment Epithelium of Eye
The layer of pigment-containing epithelial cells in the RETINA; the CILIARY BODY; and the IRIS in the eye.
Retinal Pigment Epithelium
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
Protease Inhibitors
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
Osteogenesis Imperfecta
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. (1/266)

Plasmin-alpha2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predict acute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free of clinical cardiovascular disease in 2 cohort studies: the Cardiovascular Health Study and the Honolulu Heart Program. Median PAP levels did not differ between the Cardiovascular Health Study (6.05+/-1.46 nmol/L) and the Honolulu Heart Program (6.11+/-1.44 nmol/L), and correlates of PAP were similar in both cohorts. In CHS, PAP levels increased with age (r=0. 30), procoagulant factors (eg, factor VIIc, r=0.15), thrombin activity (prothrombin fragment F1+2, r=0.29), and inflammation-sensitive proteins (eg, fibrinogen, r=0.44; factor VIIIc, r=0.37). PAP was associated with increased atherosclerosis as measured by the ankle-arm index (AAI) (P for trend, +info)

Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. (2/266)

alpha2-antiplasmin (alpha2-AP) is the main physiologic plasmin inhibitor in mammalian plasma. Inactivation of the murine alpha2-AP gene was achieved by replacing, through homologous recombination in embryonic stem cells, a 7-kb genomic sequence encoding the entire murine protein (exon 2 through part of exon 10, including the stop codon) with the neomycin resistance expression cassette. Germline transmission of the mutated allele was confirmed by Southern blot analysis. Mendelian inheritance of the inactivated alpha2-AP allele was observed, and homozygous deficient (alpha2-AP-/-) mice displayed normal fertility, viability, and development. Reverse transcription-polymerase chain reaction confirmed the absence of alpha2-AP mRNA in kidney and liver from alpha2-AP-/- mice, in contrast to wild-type (alpha2-AP+/+) mice. Immunologic and functional alpha2-AP levels were undetectable in plasma of alpha2-AP-/- mice, and were about half of wild-type in heterozygous littermates (alpha2-AP+/-). Other hemostasis parameters, including plasminogen activator inhibitor-1, plasminogen, fibrinogen, hemoglobin, hematocrit, and blood cell counts were comparable for alpha2-AP+/+, alpha2-AP+/-, and alpha2-AP-/- mice. After amputation of tail or toe tips, bleeding stopped spontaneously in alpha2-AP+/+, as well as in alpha2-AP+/- and alpha2-AP-/- mice. Spontaneous lysis after 4 hours of intravenously injected 125I-fibrin-labeled plasma clots was significantly higher in alpha2-AP-/- than in alpha2-AP+/+ mice when injecting clots prepared from alpha2-AP+/+ plasma (78% +/- 5% v 46% +/- 9%; mean +/- SEM, n = 6 to 7; P =.02) or from alpha2-AP-/- plasma (81% +/- 5% v 46% +/- 5%; mean +/- SEM, n = 5; P =.008). Four to 8 hours after endotoxin injection, fibrin deposition in the kidneys was significantly reduced in alpha2-AP-/- mice, as compared with alpha2-AP+/+ mice (P +info)

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation. (3/266)

Angiostatin, a kringle-containing fragment of plasminogen, is a potent inhibitor of angiogenesis. The mechanism(s) responsible for the anti-angiogenic properties of angiostatin are unknown. We now report that human angiostatin blocks plasmin(ogen)-enhanced in vitro invasion of tissue plasminogen activator (t-PA)-producing endothelial and melanoma cells. Kinetic analyses demonstrated that angiostatin functions as a non-competitive inhibitor of extracellular-matrix (ECM)-enhanced, t-PA-catalysed plasminogen activation, with a Ki of 0.9+/-0.03 microM. This mechanism suggests that t-PA has a binding site for the inhibitor angiostatin, as well as for its substrate plasminogen that, when occupied, prevents ternary complex formation between t-PA, plasminogen and matrix protein. Direct binding experiments confirmed that angiostatin bound to t-PA with an apparent Kd [Kd(app)] of 6.7+/-0.7 nM, but did not bind with high affinity to ECM proteins. Together, these data suggest that angiostatin in the cellular micro-environment can inhibit matrix-enhanced plasminogen activation, resulting in reduced invasive activity, and suggest a biochemical mechanism whereby angiostatin-mediated regulation of plasmin formation could influence cellular migration and invasion.  (+info)

Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. (4/266)

BACKGROUND: The role of plasminogen system components in focal cerebral ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-). METHODS AND RESULTS: FCI was produced by ligation of the left middle cerebral artery and measured after 24 hours by planimetry of stained brain slices. In control (wild-type) mice, infarct size was 7.6+/-1.1 mm3 (mean+/-SEM), uPA-/- mice had similar infarcts (7.8+/-1.0 mm3, P=NS), tPA-/- mice smaller (2.6+/-0.80 mm3, P<0.0001), PAI-1(-/-) mice larger (16+/-0.52 mm3, P<0.0001), and Plg-/- mice larger (12+/-1.2 mm3, P=0.037) infarcts. alpha2-AP-/- mice had smaller infarcts (2. 2+/-1.1 mm3, P<0.0001 versus wild-type), which increased to 13+/-2.5 mm3 (P<0.005 versus alpha2-AP-/-) after intravenous injection of human alpha2-AP. Injection into alpha2-AP-/- mice of Fab fragments of affinospecific rabbit IgG against human alpha2-AP, after injection of 200 microg human alpha2-AP, reduced FCI from 11+/-1.5 to 5.1+/-1.1 mm3 (P=0.004). CONCLUSIONS: Plg system components affect FCI at 2 different levels: (1) reduction of tPA activity (tPA gene inactivation) reduces whereas its augmentation (PAI-1 gene inactivation) increases infarct size, and (2) reduction of Plg activity (Plg gene inactivation or alpha2-AP injection) increases whereas its augmentation (alpha2-AP gene inactivation or alpha2-AP neutralization) reduces infarct size. Inhibition of alpha2-AP may constitute a potential avenue to treatment of FCI.  (+info)

Characterization of wild-type and mutant alpha2-antiplasmins: fibrinolysis enhancement by reactive site mutant. (5/266)

During human blood clotting, alpha2-antiplasmin (alpha2AP) becomes covalently linked to fibrin when activated blood clotting factor XIII (FXIIIa) catalyzes the formation of an isopeptide bond between glutamine at position two in alpha2AP and a specific epsilon-lysyl group in each of the alpha-chains of fibrin. This causes fibrin to become resistant to plasmin-mediated lysis. We found that chemically Arg-modified alpha2AP, which lacked plasmin-inhibitory activity, competed effectively with native alpha2AP for becoming cross-linked to fibrin and as a consequence, enhanced fibrinolysis. Recombinant alpha2AP reported to date by other groups either lacked or possessed a low level of FXIIIa substrate activity. As a first step in the development of an engineered protein that might have potential as a localized fibrin-specific fibrinolytic enhancer, we expressed recombinant alpha2AP in Pichia pastoris yeast. Two forms of nonglycosylated recombinant alpha2AP were expressed, isolated and characterized: (1) wild-type, which was analogous to native alpha2AP, and (2) a mutant form, which had Ala substituted for the reactive-site Arg364. Both the wild-type and mutant forms of alpha2AP functioned as FXIIIa substrates with affinities and kinetic efficiencies comparable to those of native alpha2AP, despite each having an additional acetylated Met blocking group at their respective amino-termini. Wild-type recombinant alpha2AP displayed full plasmin inhibitory activity, while mutant alpha2AP had none. Neither the absence of glycosylation nor blockage of the amino-terminus affected plasmin-inhibitory or FXIIIa substrate activities of wild-type alpha2AP. When our mutant alpha2AP, which lacked plasmin-inhibitory function, was added to human plasma or whole blood clots, urokinase (UK)-induced clot lysis was enhanced in a dose-dependent manner, indicating that mutant alpha2AP augmented lysis by competing with native alpha2AP for FXIIIa-catalyzed incorporation into fibrin.  (+info)

Hepatitis C virus NS3 serine protease interacts with the serpin C1 inhibitor. (6/266)

Both NS3 protein (1007-1657) and its protease moiety (NS3p, 1027-1207) were able to interact in vitro with C1 Inhibitor (C1Inh) to give a 95-kDa Mr C1Inh cleavage product similar to that obtained upon proteolysis by complement protease C1s. High-Mr reaction products were also detected after incubation of C1Inh with NS3 but not with NS3p; they correspond to ester-bonded complexes from their hydroxylamine lability. Similar reactivity of NS3 was observed upon incubation with alpha2-antiplasmin. Serpin cleavage was prevented by treatment of NS3 with synthetic serine protease inhibitors. This interaction between viral NS3 and host serpins suggests that NS3 is likely to be controlled by infected cell protease inhibitors.  (+info)

Solvent/detergent-treated plasma has decreased antitrypsin activity and absent antiplasmin activity. (7/266)

Solvent/detergent (S/D)-treated plasma is currently marketed by the American Red Cross as a virally inactivated alternative to fresh-frozen plasma (FFP). The serpin-type serine proteinase inhibitors have a flexible reactive site loop (RSL) that can convert from the active conformation to the inactive latent or polymerized conformations when exposed to heat and/or detergents. We have compared the conformational stability and inhibitory activity of 3 plasma serpins-antithrombin, antitrypsin, and antiplasmin-in S/D plasma and FFP. In S/D plasma, virtually 100% of the antiplasmin and approximately 50% of the antitrypsin are in either the latent or polymerized conformation and lack inhibitory activity, while in FFP only the active conformation is present. Interestingly, antithrombin is not affected by S/D treatment and remains fully active. These data demonstrate that S/D plasma is not simply a virally inactivated equivalent of FFP. The lack of antiplasmin activity and decreased antitrypsin activity in S/D plasma suggest that it may not be as effective as FFP for the treatment of bleeding in patients with systemic activation of proteolytic cascades, such as disseminated intravascular coagulation and sepsis, acquired fibrinolytic states, and large-volume transfusion. Although there has been extensive use of S/D plasma in several European countries with no reports of adverse effects, clinical studies directly comparing the efficacy of these 2 plasma products are needed to directly evaluate the relative therapeutic efficacy of FFP and S/D plasma for the treatment of these diseases.  (+info)

Comparative effects of tissue plasminogen activator, streptokinase, and staphylokinase on cerebral ischemic infarction and pulmonary clot lysis in hamster models. (8/266)

BACKGROUND: The effects of alteplase (rtPA), streptokinase, and staphylokinase (rSak) on focal cerebral ischemia (FCI) and on pulmonary clot lysis (PCL) were studied in hamsters. METHODS AND RESULTS: ++FCI was produced by ligation of the left middle cerebral artery (MCA) and common carotid artery (CCA) and a 10-minute occlusion of the right CCA. FCI was measured after 24 hours by 2,3, 5-triphenyltetrazolium chloride staining. (125)I-fibrin-labeled plasma clots were injected via the jugular vein, and clot lysis was determined from residual radioactivity at 90 minutes. Study drugs were given intravenously over 60 minutes. FCI increased from 1.2 (0. 27 to 2.3) mm(3) (median and 17th to 83rd percentile range, n=24) in controls to 19 to 27 mm(3) with thrombolytic agent, with maximal rates at 0.13+/-0.05 mg/kg rtPA, 0.23+/-0.09 mg/kg streptokinase, and 0.037+/-0.025 mg/kg rSak. PCL increased from 18+/-2% (mean+/-SEM, n=27) in controls to approximately 85% with thrombolytics, with maximal rates at 0.12+/-0.03 mg/kg rtPA, 0.17+/-0.05 mg/kg streptokinase, and 0.018+/-0.002 mg/kg rSak. All agents caused maximal FCI and PCL rates at similar doses without alpha(2)-antiplasmin and fibrinogen depletion. Injection of 6 mg/kg human plasminogen combined with streptokinase caused a "systemic fibrinolytic state" with fibrinogen depletion. Maximal rates of FCI were obtained with 0.097+/-0.077 mg/kg streptokinase (P=0.26 versus streptokinase alone) and of PCL with 0.010+/-0.002 mg/kg (P=0.006 versus streptokinase alone). CONCLUSIONS: Thrombolytic agents cause similar dose-related extension of FCI after MCA ligation and PCL, irrespective of the agent or systemic plasmin generation.  (+info)

Criteria for the specific measurement of plasmin inhibitor activity using an enzymatic procedure - IFCCCriteria for the specific measurement of plasmin inhibitor activity using an enzymatic procedure - IFCC
In the measurement of plasmin inhibitor three reactions of plasmin are of importance. First is the reaction with the PB-form of the plasmin inhibitor. Second is the reaction with the NPB-form of the plasmin inhibitor and third the reaction with a 2 -macroglobulin. Using a small excess of plasmin ( approx. 1 m M), all three reactions take place as a second order reaction ([plasmin inhibitor] total approx. [plasmin] total ). At a plasmin inhibitor concentration of 1 m M gives this a velocity for the plasmin-PB-plasmin inhibitor complex formation of 27 s -1 . For the plasmin-NPB-plasmin inhibitor complex formation this is 0.2 s -1 and for the plasmin- a 2 -macroglobulin complex formation this is 1.0 s -1 . Expressed in ratios of the complexes this is 95.7% for the plasmin-PB-plasmin inhibitor complex, 0.7% for the plasmin-NPB-plasmin inhibitor complex and 3.6% for the plasmin- a 2 -macroglobulin complex ...
http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2002-vol-13/vol-13-no-2/criteria-for-the-specific-measurement-of-plasmin-inhibitor-activity-using-an-enzymatic-procedure/
antiplasminantiplasmin
(= a 2 antiplasmin) Plasma protein (65 kD) that inhibits plasmin (and Factors XIa, XIIa, plasma kallikrein, thrombin and trypsin) and therefore acts to regulate fibrinolysis
http://en.academic.ru/dic.nsf/en_molecular_biology/472/antiplasmin
Gentaur Molecular :Meridian Life Science \ Human Alpha 2 Antiplasmin \ A50112HGentaur Molecular :Meridian Life Science \ Human Alpha 2 Antiplasmin \ A50112H
Gentaur molecular products has all kinds of products like :search , Meridian Life Science \ Human Alpha 2 Antiplasmin \ A50112H for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=327705&supplier=search&name=Human%20Alpha%202%20Antiplasmin
Alpha2-antiplasmin polymorphism and a new plasma enzyme - Patrick McKeeAlpha2-antiplasmin polymorphism and a new plasma enzyme - Patrick McKee
The serpin alpha2-antiplasmin (a2AP) has a major role in regulating fibrinolysis. This proposals goal is to (1) define interactions that determine how much a2A...
https://grantome.com/grant/NIH/R01-HL072995-04
Serpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63) (NBP2-11890): Novus BiologicalsSerpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63) (NBP2-11890): Novus Biologicals
Rat Monoclonal Anti-Serpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63). Validated: WB. Tested Reactivity: Mouse. 100% Guaranteed.
https://www.novusbio.com/products/serpin-f2-alpha-2-antiplasmin-antibody-rm0324-2h63_nbp2-11890
anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody...anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody...
anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody (Alexa Fluor 555) ABIN910642 from antibodies-online
https://www.biocompare.com/9776-Antibodies/4097378-anti-serpin-Peptidase-Inhibitor-Clade-F-Alpha-2-Antiplasmin-Pigment-Epithelium-Derived-Factor-Member-1-SERPINF1-antibody-Alexa-Fluor-555/
Antiplasmin, Activity, PlasmaAntiplasmin, Activity, Plasma
Antiplasmin, Activity, Plasma,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
http://www.bio-medicine.org/medicine-products/Antiplasmin--Activity--Plasma-21235-1/
Toward finding the gene for bovine platelet plasmin inhibitor. by Natalie Marie. LabbeToward finding the gene for bovine platelet plasmin inhibitor. by Natalie Marie. Labbe
Bovine platelet plasmin inhibitor (BPPI) is a novel Kunitz inhibitor, recently discovered in platelets (Li, 1992) for which an expression system is sought. Because the proteins origin of synthesis was unknown, a search for a genomic clone was undertaken. PCR was used in an attempt to amplify the BPPI gene from lymphocyte, bovine genomic DNA. The first set of primers used was designed according to the N and C termini of the amino acid sequence of BPPI (P1/P2). These were based on a degenerate nucleotide sequence derived from its amino acid sequence. Amplification with this set of primers was unsuccessful. The second approach in amplifying the gene was to increase the specificity of the primers in the 3 end (P3/P4) using a table of codon usage of the bovine genome. Two successive amplifications led to the formation of a 230 bp fragment. The sequence of this product was not comparable to the degenerate sequence of BPPI. A third set of primers (P6/P7) was designed according to the gene sequence of SI (II)
http://scholar.uwindsor.ca/etd/4404/
Alpha2-AntiplasminAlpha2-Antiplasmin
Each product is deficient of a specific coagulation factor or of the other hemostasis proteins. Available lyophilized and as frozen formulations.
https://www.aniara.com/CTGY/alpha2-antiplasmin.html
2012 Global Alpha-2 Antiplasmin Market Outlook: Test Volume Forecasts by Country and Market Segment2012 Global Alpha-2 Antiplasmin Market Outlook: Test Volume Forecasts by Country and Market Segment
The growing cost-containment pressures in major industrialized nations and continued technological advances will radically change coagulation testing practice
https://marketpublishers.com/report/medicine_pharmaceuticals_biotechnology/healthcare_equipment_services/alpha_2_antiplasmin_us_europe_japan_test_volume_forecasts_by_country_n_market_segment.html
CIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGENCIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGEN
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https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL83X0361555
SERPINF1 | SelfDecode | Genome AnalysisSERPINF1 | SelfDecode | Genome Analysis
hypothetical protein, alpha-2 antiplasmin, Alpha-2-antiplasmin, alpha-2 antiplasmin, pigment epithelium derived factor, AS27_04276, caspin, CB1_000765141, cell proliferation-inducing gene 35 protein, Dmrs91, EPC-1, GW7_05089, H920_13024, I79_024527, M959_13429, MDA_GLEAN10016889, N300_03473, N302_16382, N305_15082, N306_10474, N307_07373, N308_00896, N309_12586, N311_08061, N312_04929, N320_07386, N321_02844, N322_05786, N324_04587, N325_07445, N326_06640, N327_07162, N329_08729, N330_08014, N332_10702, N333_06723, N335_06305, N336_08169, N339_06481, N340_07977, N341_07059, OI12, OI6, PAL_GLEAN10020010, PANDA_006472, PEDF, Pedfl, PIG35, pigment epithelium derived factor, pigment epithelium-derived factor, pigment epithelium-derived factor-like protein, Pigment epithelium-derived factor precursor-like protein, Sdf3, SDF-3, serine (or cysteine) peptidase inhibitor, clade F, member 1, serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member ...
https://selfdecode.com/gene/serpinf1/
alpha-2 Antiplasmin - Medical Dictionary online-medical-dictionary.orgalpha-2 Antiplasmin - Medical Dictionary online-medical-dictionary.org
A member of the serpin superfamily found in Plasma that inhibits the lysis of Fibrin clots which are induced by Plasminogen Activator. It is a Glycoprotein, Molecular Weight approximately 70,000 that migrates in the alpha 2 region in Immunoelectrophoresis. It is the principal Plasmin inactivator in Blood, rapidly forming a very stable complex with Plasmin ...
http://www.online-medical-dictionary.org/definitions-a/alpha-2-antiplasmin.html
Factor XII - A Limitation for Divers?Factor XII - A Limitation for Divers?
|p| The lack of evidence for the tissue-factor dependent activation of the coagulation system and the release of thrombin on one hand, and a decreased concentration of factor XII after short term air, saturated air and heliox exposures, as well as an increased concentration of the plasmin-antiplasmin complex (PAP) after short dives indicate that diving and decompression possibly affect fibrinolysis. The aim of our research was to verify the assumption that diving and decompression activate the system of fibrinolysis and the clarification of the pathomechanism of this activation.|/p||p|The study involved 50 healthy volunteers who were subjected to short-term, air hyperbaric exposures at 400 kPa and 700 kPa, which correspond to 30m and 60m dives. Decompression was applied in accordance with Naval tables of decompression. Before hyperbaric exposition and after decompression the following factors were determined: activity of factor XII, concentration and activity of t-PA, concentration and activity of PAI-1
https://www.infona.pl/resource/bwmeta1.element.-psjd-doi-10_1515_phr-2015-0012
Antiplasmin DeficiencyAntiplasmin Deficiency
Neurology news, research and treatment studies for epilepsy, neurodegenerative disorders, patients with MS and other brain and central nervous system disorders and diseases.
http://www.neurologyadvisor.com/labmed/antiplasmin-deficiency/article/613207/
Hip Mobility / Flexibility / Stability Drills 5 - Childs Pose Complex - Level 1 | The Physio DetectiveHip Mobility / Flexibility / Stability Drills 5 - Childs Pose Complex - Level 1 | The Physio Detective
This Childs Pose Complex - Level 1 is a nice way to integrate a lot of different movements. Firstly, we are aiming to activate and rotate the thorax and arms before moving into full spinal extension which stretches out your abdominals and anterior thorax. We then bend the knee with a pointed foot to target…
https://physiodetective.wordpress.com/2015/08/21/hip-mobility-flexibility-stability-drills-5-childs-pose-complex-level-1/
Plasmin, plasmin inhibitors, and degradation products of fibrinogen in human serum during and after intravenous infusion of...Plasmin, plasmin inhibitors, and degradation products of fibrinogen in human serum during and after intravenous infusion of...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
https://jcp.bmj.com/content/22/3/371.2.info
anti-PEDF antibody [N1C2] | GeneTexanti-PEDF antibody [N1C2] | GeneTex
PEDF antibody [N1C2] (serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1) for IHC-P, WB. Anti-PEDF pAb (GTX114097) is tested in Human, Mouse samples. 100% Ab-Assurance.
http://www.genetex.com/PEDF-antibody-N1C2-GTX114097.html
Fibrinolysis - DiapharmaFibrinolysis - Diapharma
Inhibition of Fibrinolysis. For maintaining high fidelity regulation between coagulatory clotting and proteolytic fibrinolysis TAFI (Thrombin activatable fibrinolysis inhibitor) plays an important inhibitory role. Apart from this, four different forms of plasminogen activator inhibitors, denoted PAI-1 to PAI-4, are also known.. PAI-1, which is the most prominent form, is mainly synthesized in endothelial cells and stored in thrombocytes. Its release is concentrated to platelet rich clots leading to an increased thrombus resistance to fibrinolysis. Another fibrinolysis inhibitor is the plasmin inhibitor (α2-antiplasmin). FXIIIa makes it an initial clot stabilizer by rapidly and covalently binding this inhibitor to fibrin. The role of inhibiting plasmin is made directly by a 1:1-complex formation between plasmin and antiplasmin (PAP). PAP can be immunologically detected in plasma, and is therefore used as a diagnostic parameter for proving thrombosis.. Function of plasmin. The fibrinogen molecule ...
https://diapharma.com/fibrinolysis/
Process Engineer - Enschede, Netherlands - EnschedeProcess Engineer - Enschede, Netherlands - Enschede
Process Engineer - Enschede, Netherlands 01 October, 2019 Process Engineer - Enschede, Netherlands Leap29 are working with a leading EPC company, our clien...
https://www.rigzone.com/oil/jobs/postings/1036427_process_engineer_enschede_netherlands/
The most insightful stories about Enschede - MediumThe most insightful stories about Enschede - Medium
Read stories about Enschede on Medium. Discover smart, unique perspectives on Enschede and the topics that matter most to you like easygiving, eindhoven, about me, arnhem, and bart van meijl.
https://medium.com/tag/enschede
Abstract 19961: Protein-based Risk Score Increases Prior to Cardiovascular Events and Death in Individuals With Apparently...Abstract 19961: Protein-based Risk Score Increases Prior to Cardiovascular Events and Death in Individuals With Apparently...
Starting with 1130 plasma proteins, we previously derived and then externally validated a 9 protein model (CVD9 [angiopoietin 2, complement C7, α-2 antiplasmin, matrix metalloproteinase 12, α-1 antichymotrypsin complex, growth differentiation factors 11/8, chemokine (C-C motif) ligand 18, angiopoietin related protein 4 and troponin I]) to predict 4-year probability of death, myocardial infarction, stroke and heart failure using SOMAscan proteomic technology in subjects with stable coronary heart disease (CHD). In the current study, we tested whether this proteomic risk score increases within individuals as they approach an event. We applied CVD9 to paired plasma samples from 513 subjects in the Heart and Soul study who were still event free when a second blood sample was taken 4.8 years after the first. There were 139 subjects who had events a median of 2.9 years after their second sample, compared to 374 subjects who did not have events after their second sample (with a median of 4.3 years of ...
http://circ.ahajournals.org/content/132/Suppl_3/A19961
Kansen en bedreigingen in de omgeving | Bedrijfsruimte huren Breda, kantoor huren in EnschedeKansen en bedreigingen in de omgeving | Bedrijfsruimte huren Breda, kantoor huren in Enschede
SWOT-analyse. SWOT staat voor Strengths (sterkten), Weaknesses (zwakten), Opportunities (kansen) en Threats (bedreigingen). Met deze analyse probeert men op een systematische manier de Bedrijfspand huren in Breda kansen en bedreigingen in de omgeving van de vastgoedorganisatie te analyseren. Het analyseren van kansen en bedreigingen wordt ook wel externe analyse genoemd. De externe analyse op bedrijfsniveau bevat een omgevingsanalyse, terwijl bedrijfspand huren Enschede op productniveau de vraag naar vastgoed centraal staat. Ook worden de sterkten en zwakten van de vastgoedorganisatie of vastgoedportefeuille bekeken (interne analyse). De interne analyse op bedrijfsniveau omvat een bedrijfsanalyse, terwijl op productniveau het aanbod van vastgoed centraal staat. De toegevoegde waarde van een SWOT-analyse is gelegen in de confrontatie van kansen en bedrijfsruimte huren Almere bedreigingen in de omgeving met de sterkten en zwakten van de vastgoedorganisatie; met behulp van deze confrontatie worden ...
http://www.plezierkapel.nl/bedrijfsruimte-huren-of-kopen/kansen-en-bedreigingen-in-de-omgeving/
Top 10 Hotels in Enschede, Netherlands | Hotels.comTop 10 Hotels in Enschede, Netherlands | Hotels.com
Compare 7 hotels in Enschede using 363 real guest reviews. Earn free nights and get our Price Guarantee - booking has never been easier on Hotels.com!
https://www.hotels.com/de935056/hotels-enschede-netherlands/?pos=HCOM_US&locale=en_US
Top 10 Hotels in Enschede, Netherlands | Hotels.comTop 10 Hotels in Enschede, Netherlands | Hotels.com
Compare 7 hotels in Enschede using 363 real guest reviews. Earn free nights and get our Price Guarantee - booking has never been easier on Hotels.com!
https://www.hotels.com/de935056/hotels-enschede-netherlands/
TransportTransport
Train departures (final destination Enschede) are seven minutes to the hour (there is another train seven minutes to the half hour; you then have to switch in Amersfoort , the train to Hengelo/Enschede is waiting at the other side of the platform). Note that this train does not pass through Amsterdam Central Station and takes a little more than two hours to arrive in Hengelo. ...
https://www.utwente.nl/en/bms/wijsb/archive-activities/2010-older/ecap_conference_2007/practical_info/transport/
CETL- Assessment Resource CentreCETL- Assessment Resource Centre
Biggs Solo (Structure of the Observed Learning Outcome) Taxonomy is a systematic way of describing how a learner s performance develops from simple to complex levels in their learning. There are 5 stages, namely Pre-structural, Uni-structural, Multi-structural which are in a quantitative phrase and Relational and Extended Abstract which are in a qualitative phrase. ...
http://ar.cetl.hku.hk/bloom.htm
天然小鼠Plasmin蛋白(ab92885)|Abcam中国天然小鼠Plasmin蛋白(ab92885)|Abcam中国
购买我们的天然小鼠Plasmin蛋白。Ab92885从天然组织中纯化得来，经过SDS-PAGE实验验证。Abcam提供免费的实验方案，操作技巧及专业的支持。中国80%以上现货。
http://www.abcam.cn/natural-mouse-plasmin-protein-ab92885.html
Plasmin-antiplasmin system<...Plasmin-antiplasmin system<...
TY - CHAP. T1 - Plasmin-antiplasmin system. AU - Mutch, Nicola J.. AU - Booth, Nuala A.. PY - 2016/4/19. Y1 - 2016/4/19. N2 - Plasmin is the key enzyme involved in the dissolution of fibrin. It is produced from plasminogen, which is activated by a plasminogen activator; the two primary activators are tissue-type plasminogen activator (tPA) and urinary-type plasminogen activator (uPA), also called urokinase. The process is regulated by inhibitors, principally plasminogen activator inhibitor 1 (PAI-1), α2-antiplasmin (α2AP) and thrombin-activatable fibrinolysis inhibitor (TAFI). Crucial control is exerted by surfaces, such as fibrin or cells, with plasminogen activation not normally occurring in the circulation. Here we will consider the individual players of the fibrinolytic cascade and their specific locations and potential interactions. Key questions considered are the initiation of fibrinolysis and the most appropriate ways to measure abnormalities in disease situations.. AB - Plasmin is the ...
https://abdn.pure.elsevier.com/en/publications/plasmin-antiplasmin-system
Disseminated intravascular coagulation during human septic shock: relation with lactate levels | Critical Care | Full TextDisseminated intravascular coagulation during human septic shock: relation with lactate levels | Critical Care | Full Text
We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables, and plasma levels of lactate, thrombin-antithrombin complexes (TAT), tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI) and plasmin-α2-antiplasmin complexes and TNFα, IL-6 and complement activation product C3a were measured 6-hourly. ...
https://ccforum.biomedcentral.com/articles/10.1186/cc8091
Enschede Airport Twente | OpenBuildingsEnschede Airport Twente | OpenBuildings
Enschede Airport Twente ( IATA: ENS, ICAO: EHTW) is located 2 NM (3.7 km; 2.3 mi) north from Enschede, a municipality in the Twente region and the Overijssel province of the Netherlands. It has one…
http://openbuildings.com/buildings/enschede-airport-twente-profile-28465
PAB972Hu01 | Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) | Homo sapiens (Human) USCN(Wuhan USCN Business Co...PAB972Hu01 | Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF) | Homo sapiens (Human) USCN(Wuhan USCN Business Co...
PAB972Hu01, Polyclonal Antibody to Pigment Epithelium Derived Factor (PEDF), SERPINF1; EPC1; PIG35; SDF3; Serpin F1; Cell proliferation-inducing gene 35; Serpin Peptidase Inhibitor,Clade F Member 1(Alpha-2 Antiplasmin); Stromal Cell Derived Factor 3 | Products for research use only!
http://www.uscnk.com/uscn/Antibody-to-Pigment-Epithelium-Derived-Factor-PEDF-14445.htm
Immune complex levels and HBs-antigenaemia in healthy Nigerians and patients with liver diseases.Immune complex levels and HBs-antigenaemia in healthy Nigerians and patients with liver diseases.
Circulating immune complexes (CIC) were precipitated and assayed in the blood of 19 adult patients with liver diseases and 39 healthy adult Nigerians. The presence of hepatitis-Bs antigen (HBs-Ag) was also investigated in both the sera and CIC of bot
http://www.biomedsearch.com/nih/Immune-complex-levels-HBs-antigenaemia/1308079.html
Akzent Hotel Tietmeyer, Schöppingen, Germany - Booking.comAkzent Hotel Tietmeyer, Schöppingen, Germany - Booking.com
Akzent Hotel Tietmeyer is located in Schöppingen, 19 miles from Münster and 17 miles from Enschede. Guests can enjoy the on-site bar.
https://www.booking.com/hotel/de/akzent-tietmeyer.html
Natural rat Plasmin protein (ab92813) | AbcamNatural rat Plasmin protein (ab92813) | Abcam
Buy our Natural rat Plasmin protein. Ab92813 is an active full length protein produced in Nativesyntheticaly and has been validated in SDS-PAGE. Abcam provides…
http://www.abcam.com/natural-rat-plasmin-protein-ab92813.html
Increased thrombin levels during thrombolytic therapy in acute myocardial infarction. Relevance for the success of therapy. |...Increased thrombin levels during thrombolytic therapy in acute myocardial infarction. Relevance for the success of therapy. |...
METHODS AND RESULTS Fifty-five patients were treated with urokinase-preactivated prourokinase (n = 35) or tissue-type plasminogen activator (n = 20) for acute myocardial infarction and underwent coronary angiography at 90 minutes and at 24-36 hours into thrombolysis, and fibrinogen (Ratnoff-Menzie), D-dimer (ELISA) and thrombin-antithrombin III complex levels (ELISA) were measured. Primary patency was achieved in 39 patients (70.9%), 13 of whom (33.3%) suffered early reocclusion. Nonsignificant decreases in fibrinogen levels were observed while D-dimer levels increased +3,008 +/- 4,047 micrograms/l (p less than 0.01), differences not being significant in respect to the thrombolytic agents or to the clinical course. In contrast, while thrombin-antithrombin III complex levels decreased -4.4 +/- 13.0 micrograms/l in patients with persistent patency, they increased +7.5 +/- 13.6 micrograms/l in case of nonsuccessful thrombolysis (p less than 0.02) and +11.9 +/- 23.8 micrograms/l in case of early ...
http://circ.ahajournals.org/content/83/3/937
Plus itPlus it
The present study was undertaken to determine whether highly purified human urinary trypsin inhibitor (UTI) efficiently inhibits the soluble and the tumor cell receptor-bound plasmin. The ability of plasmin inhibitors to regulate invasion by tumor cells which express membrane-associated plasmin was also examined. UTI and two other plasmin inhibitors [α2-anti-plasmin (α2AP) and α2-macroglobulin (α2M)] were used. α2AP and α2M, as well as UTI, rapidly inactivate the soluble plasmin that is not bound to cells. Experiments were performed in vitro using cultures of ovarian cancer HOC-I cells and gestational choriocarcinoma SMT-ccl cells. HOC-I and SMT-ccl cells had plasmin(ogen) on their cell surface, and the plasmin activity was detected on their cell surface enzymologically and immunologically. Receptor-bound plasmin reacted effectively with UTI and was directly inactivated by UTI. In contrast, receptor-bound plasmin was not inhibited by α2AP and α2M. Using a modified Boyden chamber and an ...
http://cancerres.aacrjournals.org/content/54/3/844
Proteins produced and secreted by the liver - WikipediaProteins produced and secreted by the liver - Wikipedia
The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis, carrier proteins, hormones, prohormones and apolipoprotein: Human serum albumin, osmolyte and carrier protein α-fetoprotein, the fetal counterpart of serum albumin Soluble plasma fibronectin, forming a blood clot that stops bleeding C-reactive protein, opsonin on microbes, acute phase protein Various other globulins Stimulators of coagulation: All factors in the coagulation cascade. While the endothelium does produce some factor VIII, the majority of factor VIII is produced in the liver. Inhibitors of coagulation:, inactivate an enormous variety of proteinases α2-macroglobulin α1-antitrypsin Antithrombin III Protein S Protein C Fibrinolysis:, breakdown of fibrin clots plasminogen Inhibitors of fibrinolysis α2-antiplasmin Complement components C1-9, Complement component 3 (C3) Albumin, carries thyroid hormones and other hormones, ...
https://en.wikipedia.org/wiki/Proteins_produced_and_secreted_by_the_liver
Inhibition of Plasminogen Activator Inhibitor-1 | Arteriosclerosis, Thrombosis, and Vascular BiologyInhibition of Plasminogen Activator Inhibitor-1 | Arteriosclerosis, Thrombosis, and Vascular Biology
Relying on virtual screening and the 3-dimensional structure of the complex of PAI-1 with its inhibitory peptide, we have identified 2 novel, orally bioavailable, small molecule PAI-1 inhibitors, TM5001 and TM5007. Both are stable, nontoxic, and devoid of cellular toxicity as demonstrated in vitro by their inability to raise LDH levels in the medium of cultured HeLa cells. The absence of acute and subacute toxicity is confirmed in vivo in mice given a single dose of up to 2000 mg/kg, or in rats fed 300 mg/kg for 1 week or 2000 mg/kg for 2 weeks. The in vivo effectiveness of TM5007 is demonstrated in animal models of either acute vascular thrombosis or of chronic lung fibrosis, without deleterious effects on blood pressure or bleeding, in good agreement with previous results in PAI-1 deficient mice and humans.8,14. The specificity of the effect of TM5007 on PAI-I was further documented in other serpin/serine protease systems (ie, α1-antitrypsin/trypsin and α2-antiplasmin/plasmin) by a ...
http://atvb.ahajournals.org/content/28/4/672.full
Inhibition of Plasminogen Activator Inhibitor-1 | Arteriosclerosis, Thrombosis, and Vascular BiologyInhibition of Plasminogen Activator Inhibitor-1 | Arteriosclerosis, Thrombosis, and Vascular Biology
Relying on virtual screening and the 3-dimensional structure of the complex of PAI-1 with its inhibitory peptide, we have identified 2 novel, orally bioavailable, small molecule PAI-1 inhibitors, TM5001 and TM5007. Both are stable, nontoxic, and devoid of cellular toxicity as demonstrated in vitro by their inability to raise LDH levels in the medium of cultured HeLa cells. The absence of acute and subacute toxicity is confirmed in vivo in mice given a single dose of up to 2000 mg/kg, or in rats fed 300 mg/kg for 1 week or 2000 mg/kg for 2 weeks. The in vivo effectiveness of TM5007 is demonstrated in animal models of either acute vascular thrombosis or of chronic lung fibrosis, without deleterious effects on blood pressure or bleeding, in good agreement with previous results in PAI-1 deficient mice and humans.8,14. The specificity of the effect of TM5007 on PAI-I was further documented in other serpin/serine protease systems (ie, α1-antitrypsin/trypsin and α2-antiplasmin/plasmin) by a ...
http://atvb.ahajournals.org/content/28/4/672
Impact of kidney donor hemostasis on risk of complications after transplantation - preliminary outcomes - Article abstract ...Impact of kidney donor hemostasis on risk of complications after transplantation - preliminary outcomes - Article abstract ...
Background:This study analyzes the influence the of kidney donor hemostasis on the risk of complications in the kidney recipient after transplantation. Material and Methods:We enrolled 38 deceased kidney donors, of whom14 donors died from a physical injury and the others died from ischemic or bleeding central nervous system stroke. The donors were categorized into 2 subgroups. If the recipients postoperative period proceeded smoothly, the kidney donor was assigned to the uncomplicated donors (UD) group. If the recipients postoperative period was complicated, the donor was assigned to the complicated (CD) Group. The CD group of consisted of 9 donors who died from strokes or bleedings and 2 who died from physical injury. We examined the antithrombin (AT) protein C (PC), complexes of thrombin/antithrombin (TAT), fragments F1+2 of prothrombin (F1+2), plasminogen (Pl), complexes of plasmin/antiplasmin (PAP), and D-dimers (D-d). Results:In the CD group had decreased activity of AT, PC, and Pl and increased
https://www.medscimonit.com/abstract/index/idArt/884030/act/2
Denie AugustijnDenie Augustijn
Hulscher, S.J.M.H., R.M.J. Schielen, D.C.M. Augustijn, J.J. Warmink, M.C. van der Voort, H. Middelkoop, M.G. Kleinhans, R.S.E.W. Leuven, H.J.R. Lenders, A.J.M. Smits, J.M. Fliervoet, W.S.J. Uijttewaal, A. Blom, J. Wallinga, A.J.F. Hoitink, A.D. Buijse, G.W. Geerling, B. Makaske (2014) Rivercare: towards self-sustaining multifunctional rivers. In: Augustijn, D.C.M., J.J. Warmink (2014) Book of Abstracts NCR-Days 2014 Enschede, October 2-3. NRC publication 38-2014. Enschede, The Netherlands pp. 13-14 ...
https://www.utwente.nl/en/et/wem/staff/augustijn/
Slicebooks Store - Peter PhilippsonSlicebooks Store - Peter Philippson
3.1 Theory. We have been looking at how new complex systems can emerge from non-linear field interactions, where feedback loops replace simple linear cause-and-effect chains. We have looked at the increasingly complex levels of life, intelligence and choicefulness. The question I want to explore in this chapter is: how does this happen in the case of our emergent conscious self? What are the nuts and bolts of the interactions leading to my ability to be myself?. Notice how this is immediately a different question from the more familiar ones of how conscious self affects the environment, or vice versa. Both of these assume a primary separation of self from environment, so that the interactions each way can be charted. But using the three boundaries language from Chapter Two, we can see how this oversimplifies the situation. Self and environment do not belong to the same level of interaction. Environment engages with organism at the physical contact boundary; self engages with other at the ...
https://store.slicebooks.com/products/authors/94626/list
OCA:1BMLOCA:1BML
reference: Crystal structure of the catalytic domain of human plasmin complexed with streptokinase., Wang X, Lin X, Loy JA, Tang J, Zhang XC, Science 1998 Sep 11;281(5383):1662-5. PMID: 9733510 ...
http://oca.weizmann.ac.il/oca-bin/ccpeek?id=1BML
ಡಿ-ಡೈಮರ್ - ಇದು ಏನು? ಯಾವ ರೋಗಗಳು ಒಂದು ವಿಶ್ಲೇಷಣೆ ತೆಗೆದುಕೊಳ್ಳುವ ಅಗತ್ಯವಿಲ್ಲ?ಡಿ-ಡೈಮರ್ - ಇದು ಏನು? ಯಾವ ರೋಗಗಳು ಒಂದು ವಿಶ್ಲೇಷಣೆ ತೆಗೆದುಕೊಳ್ಳುವ ಅಗತ್ಯವಿಲ್ಲ?
ರಕ್ತ ಹೆಪ್ಪುಗಟ್ಟುವಿಕೆ ಯಾಂತ್ರಿಕ ಅತ್ಯಂತ ಸಂಕೀರ್ಣವಾಗಿದೆ. ನಾವು ಒಟ್ಟಾರೆಯಾಗಿ ಆದರೆ, ಇದು ಈ ತೋರುತ್ತಿದೆ. thrombin ರೂಪುಗೊಂಡ ಫಿಬ್ರಿನ್ ನಂತಹ ಪ್ರಿಟಾಯಿಕ್ ಮೂಲ ನಂತರ plasmin ಉತ್ತರದಾಯಿ ಆಗಿದೆ ಆಕ್ಷನ್ ಅಡಿಯಲ್ಲಿ. ಈ ಕಿಣ್ವವು ಭೇದಿಸುತ್ತದೆ ಫಿಬ್ರಿನ್ ನಂತಹ ಪ್ರಿಟಾಯಿಕ್ ಮೂಲ ಮತ್ತು ಸಣ್ಣ ತುಣುಕಿನ ಒಳಗೆ ಫೈಬ್ರಿನೊಜೆನ್ ಅಣುಗಳು. ಕೆಲವೊಮ್ಮೆ, fibrinolytic plasmin ಸಾಧ್ಯವಿಲ್ಲ ಸಂಪೂರ್ಣವಾಗಿ ಕ್ಲೀವ್ fibrnovoe ಫೈಬರ್, ಮತ್ತು ಆ ಮೂಲಕ ರೂಪುಗೊಂಡ ಡಿ dimers ...
https://kn.unansea.com/%E0%B2%A1%E0%B2%BF-%E0%B2%A1%E0%B3%86%E0%B3%96%E0%B2%AE%E0%B2%B0%E0%B3%8D-%E0%B2%87%E0%B2%A6%E0%B3%81-%E0%B2%8F%E0%B2%A8%E0%B3%81-%E0%B2%AF%E0%B2%BE%E0%B2%B5/
2014 UK Coagulation Testing Market : Segmentation, Technology, Current & Emerging Products Analyzed: ReportsnReports.com -...2014 UK Coagulation Testing Market : Segmentation, Technology, Current & Emerging Products Analyzed: ReportsnReports.com -...
ReportsnReports.com adds report 2014 Strategies for the UK Coagulation Testing Market to its store. This comprehensive report contains 409 pages, 35 tables, and is designed to help current suppliers and potential market entrants identify and evaluate business opportunities emerging in the UK coagulation testing market during the next five years.. The report explores business and technological trends in the UK coagulation testing market; provides estimates of the test volume, as well as sales and market shares of leading competitors; compares features of major analyzers; profiles leading market players; and identifies specific product and business opportunities facing instrument and consumable suppliers during the next five years.. Coagulation Tests. Activated Clotting Time (ACT) (1), Activated Protein C Resistance, Activated PTT (APTT), Alpha 2-Antiplasmin, Antithrombin III, Bleeding Time, D-Dimer, Factor II, Factor V, Factor V Leiden, Factor VII, Factor VIII, Factor IX, Factor Ixa, Factor X ...
https://pitchengine.com/pitches/8ddaeab5-3f3e-4608-a355-02bf6db0c128
Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in...Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in...
Fingerprint Dive into the research topics of Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in children and adults. Together they form a unique fingerprint. ...
https://jhu.pure.elsevier.com/en/publications/simultaneous-thrombin-and-plasmin-generation-capacities-in-normal-3/fingerprints/
Euglobulin Lysis Time [462n] - GBMC Test DictionaryEuglobulin Lysis Time [462n] - GBMC Test Dictionary
ECLT provides an overall assessment of the fibrinolysis system by measuring the time for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. ECLT is useful in assessing the fibrinolytic system and monitoring patients on urokinase or streptokinase fibrinolytic therapy ...
http://www.specialtylabs.com/clients/gbmc/details.asp?id=S41505&spt=true
The Dr. Rath Health FoundationThe Dr. Rath Health Foundation
Plasmin-induced tissue degradation contributes to the proliferation of most diseases. Of particular interest is the fact that similar mechanisms are induced by attacking pathogens as they are used by the defending host cells, e.g. macrophages. In many pathological conditions macrophages become activated. This activation reflects a particular state of alert that is characterized by an abundant release of secretory products. These products include oxygen metabolites, collagenases, elastases, and a significantly increased secretion of plasminogen activators. It is immediately obvious that this mechanism needs to be precisely controlled. Therefore macrophages also secrete inhibitory products including plasmin inhibitors and a2-macroglobulin which are able to inactivate plasmin and many other proteases. Any imbalance in this control system leads to an exacerbation of this mechanism and to continued tissue degradation. Chronic activation of macrophages and an exertion of the control mechanisms ...
http://www4ger.dr-rath-foundation.org/DIE_FOUNDATION/dr_rath/publications/pub10.htm
Calcium Ion-Induced Enzyme Dissociation and the Appearance of Enzyme Activity in Human Plasma Factor XIII | Biochemical Society...Calcium Ion-Induced Enzyme Dissociation and the Appearance of Enzyme Activity in Human Plasma Factor XIII | Biochemical Society...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/1/5/1198
Health Sciences, M.Sc. | University of Twente (UT) | Enschede, NetherlandsHealth Sciences, M.Sc. | University of Twente (UT) | Enschede, Netherlands
The Health Sciences programme offered by University of Twente (UT) educates health scientists who are able to design solutions to the challenges presented by
https://www.mastersportal.com/studies/360/health-sciences.html
Great and cheap pellet in Holland! [Archive] - Guinea Pig Cages, Care, Photos, News, Forum and BlogsGreat and cheap pellet in Holland! [Archive] - Guinea Pig Cages, Care, Photos, News, Forum and Blogs
Hey!, Ive got a very nice source of pure pellets specially for guinea pigs in Enschede, Holland. :D This is the place: Zaadhandel Kootstra Wethouder Elhorststraat 86 -88 7543 TE ENSCHEDE NEDERLAND
https://www.guineapigcages.com/forum/archive/index.php/t-34091.html?s=2f05f74004ece6fe5e03042dbe5689ba
Condition+ Restore Vegan Conditioner | 165ml from LØRE OriginalsCondition+ Restore Vegan Conditioner | 165ml from LØRE Originals
Please note: this product does not ship to US and Canada. A nutrient-rich, protecting formula with scientific actives from volcanic marine waters, 165ml. This unique, lightweight conditioning formula is rich in natural oils, essential acids, marine plant cultures and advanced scientific compounds. Complex levels of cor
https://immaculatevegan.com/products/condition-restore
DYSOL ... - Brenntag product information pageDYSOL ... - Brenntag product information page
DYSOL ... - Brenntag product information page Brenntag is Beneluxs leading distributor and exporter of industrial chemicals and specialties, located in Belgium (Deerlijk, Antwerpen & Mouscron) and the Netherlands (Dordrecht, Loosdrecht, Zwijndrecht, Moerdijk, Rotterdam, Enschede).
http://brenntag.be/prd/product/dysolen.php
Local discontinous galerkin methods for phase transition problems</em>...Local discontinous galerkin methods for phase transition problems</em>...
TY - THES. T1 - Local discontinous galerkin methods for phase transition problems. AU - Tian, L.. PY - 2015. Y1 - 2015. U2 - 10.3990/1.9789036539586. DO - 10.3990/1.9789036539586. M3 - Phd Thesis 4 Research NOT TU/e / Graduation NOT TU/e). SN - 978-90-365-3958-6. PB - Gildeprint. CY - Enschede. ER - ...
https://research.tue.nl/en/publications/local-discontinous-galerkin-methods-for-phase-transition-problems
How Endovan works in endometriosisHow Endovan works in endometriosis
Endovan increases the fibrinolytic activity (fibrin-degrading) in the blood by encouraging increased plasmin production as well as by mimicking the function of plasmin.. With a more robust plasmin response, the body is better able to break down accumulated fibrin allowing the immune system to clean up the site and direct the debris to be processed as waste.. Try Endovan Today. ...
https://www.endovan.com/endometriosis/how-it-works
Deactivation of biacetyl triplets by cyanocobaltate(III) complexes - CaltechAUTHORSDeactivation of biacetyl triplets by cyanocobaltate(III) complexes - CaltechAUTHORS
The rate of electronic energy transfer from biacetyl triplets to Co(CN)_(5)(X)^(n-)(X = CN^-, MeCN, pyridine, N_(3)^-, H_(2)O, or SCN^-) is strongly dependent on the energy of the first spin-allowed d-d transition of Co(CN)_(5)(X)^(n-), and (for X = CN^-, N_(3)^-, and SCN^-) the direct and sensitized photosubstitution yields are the same, implying a common reactive state. ...
https://authors.library.caltech.edu/33178/
Museum of Contemporary PhotographyMuseum of Contemporary Photography
Among Winogrands favorite subjects were women, and he described himself as being compulsively interested in women and having compulsively photographed women. A large part of Winogrands images in the collection of the MoCP form part of the Women are Beautiful portfolio (1981), which was initially published as a monograph in 1975. For the monograph, John Szarkowski, curator of photography at The Museum of Modern Art in New York at the time, selected eighty-five images featuring women from hundreds of photographs by Winogrand. The resulting book offers a random collection of women caught on the street, in parks, getting into cars, at parties, marching in parades, skinny-dipping in ponds, etc. The images capture not only Winogrands attraction to the women he photographed, but also the styles, activities, gestures, and energies pertaining to gender in the 1960s and 1970s, an era of transition during second-wave feminism and the sexual revolution. In the monograph and in the portfolio, ...
http://www.mocp.org/detail.php?t=objects&type=tag&f=1014&s=&record=1&tag=lake
Marketing - Bridging Program for Internationally Educated ProfessionalsMarketing - Bridging Program for Internationally Educated Professionals
Enhance your marketing skills to meet the demands of todays competitive environment while learning from experienced professors.
https://www.yorku.ca/laps/iep/certificate-in-canadian-business/marketing/
Trypsin 1Trypsin 1
Shieh BH, Travis J (1987). "The reactive site of human alpha 2-antiplasmin". J. Biol. Chem. 262 (13): 6055-9. PMID 2437112. ... 1997). "Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional ... 3.0.CO;2-P. PMID 9633818. Chen JM, Ferec C (2000). "Molecular basis of hereditary pancreatitis". Eur. J. Hum. Genet. 8 (7): 473 ... 41 (2-3): 305-10. doi:10.1016/0378-1119(86)90111-3. PMID 3011602. Honey NK, Sakaguchi AY, Quinto C, et al. (1984). "Chromosomal ...
https://en.wikipedia.org/wiki/Trypsin_1
PlasminPlasmin
Wiman B, Collen D (September 1979). "On the mechanism of the reaction between human alpha 2-antiplasmin and plasmin". J. Biol. ... Plasmin is inactivated by proteins such as α2-macroglobulin and α2-antiplasmin. The mechanism of plasmin inactivation involves ... Shieh BH, Travis J (May 1987). "The reactive site of human alpha 2-antiplasmin". J. Biol. Chem. 262 (13): 6055-9. PMID 2437112 ... Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin and IGFBP3. Moreover, plasmin induces the ...
https://en.wikipedia.org/wiki/Plasmin
Neutrophil elastaseNeutrophil elastase
Shieh BH, Travis J (May 1987). "The reactive site of human alpha 2-antiplasmin". J. Biol. Chem. 262 (13): 6055-9. PMID 2437112 ... Brower MS, Harpel PC (August 1982). "Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by ... Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin, which belongs to the Serpin family of proteins. ... Humans have six elastase genes that encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Neutrophil ...
https://en.wikipedia.org/wiki/Neutrophil_elastase
FibrinolysisFibrinolysis
Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin. Plasmin activity is also reduced by thrombin-activatable ... Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ... Nevertheless, excess levels of PAI and alpha 2-antiplasmin have been implicated in the metabolic syndrome and various other ... alpha 2-antiplasmin, and plasminogen) from plasma and then observing the time required for clot dissolution. A shortened lysis ...
https://en.wikipedia.org/wiki/Fibrinolysis
HyperfibrinolysisHyperfibrinolysis
Carpenter SL, Mathew P (2008). "Alpha-2-antiplasmin and its deficiency: fibrinolysis out of balance". Haemophilia. 14: 1250-4. ... Among the congenital conditions for hyperfibrinolysis, deficiency of alpha-2-antiplasmin (alpha-2-plasmin inhibitor) or ... complexes of plasmin and alpha-2-antiplasmin (PAP). However, the sensitivity and specificity of these methods is limited ...
https://en.wikipedia.org/wiki/Hyperfibrinolysis
Helge StormorkenHelge Stormorken
Gogstad, GO; Stormorken, H; Solum, NO (15 July 1983). "Platelet alpha 2-antiplasmin is located in the platelet alpha-granules ... Stormorken, H; Gogstad, GO; Brosstad, F (August 1983). "Hereditary α2-antiplasmin deficiency". Thrombosis Research. 31 (4): 647 ... 5 (2): 129-37. doi:10.1111/j.1600-0609.1968.tb01727.x. PMID 5673825. Holmsen, H; Day, HJ; Stormorken, H (1969). "The blood ... 34 (2): 587-8. PMID 1105879. Dale, J; Myhre, E; Storstein, O; Stormorken, H; Efskind, L (July 1977). "Prevention of arterial ...
https://en.wikipedia.org/wiki/Helge_Stormorken
CoagulationCoagulation
alpha 2-antiplasmin. Inhibits plasmin. Antiplasmin deficiency tissue plasminogen activator (tPA). Activates plasminogen. ... 978-1-904842-39-2. .. *^ a b c d e f g Pallister CJ, Watson MS (2010). Haematology. Scion Publishing. pp. 336-347. ISBN 978-1- ... The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which ... deficient alpha granules), and delta storage pool deficiency (deficient dense granules). Most are rare. They predispose to ...
https://en.m.wikipedia.org/wiki/Blood_coagulation
CoagulationCoagulation
alpha 2-antiplasmin. Inhibits plasmin. Antiplasmin deficiency. tissue plasminogen activator (tPA). Activates plasminogen. ... The interaction of vWF and GP1b alpha. The GP1b receptor on the surface of platelets allows the platelet to bind to vWF, which ... deficient alpha granules), and delta storage pool deficiency (deficient dense granules). Most are rare conditions. Most inborn ... p. 2. ISBN 978-1-4051-8460-1.. *^ Pallister CJ, Watson MS (2010). Haematology. Scion Publishing. pp. 334-336. ISBN 1-904842-39- ...
https://en.m.wikipedia.org/wiki/Coagulation
SerpinSerpin
The disorder alpha-1 antitrypsin deficiency is one of the most common hereditary diseases. Since the stressed serpin fold is ... Lijnen HR, Okada K, Matsuo O, Collen D, Dewerchin M (April 1999). "Alpha2-antiplasmin gene deficiency in mice is associated ... alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder". The New England Journal of Medicine. 309 (12 ... Lomas DA, Evans DL, Finch JT, Carrell RW (June 1992). "The mechanism of Z alpha 1-antitrypsin accumulation in the liver". ...
https://en.wikipedia.org/wiki/Serpin
PEDFPEDF
The PEDF structure includes 3 beta sheets and 10 alpha helices. This discovery demonstrated that PEDF has an asymmetrical ... "Entrez Gene: SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1". ... 76 (2): 213-23. doi:10.1016/j.cardiores.2007.06.032. PMID 17651710. Guan M, Pang CP, Yam HF, Cheung KF, Liu WW, Lu Y (May 2004 ... 113 (2): 294-301. doi:10.1016/j.ophtha.2005.10.030. PMID 16406543. Becker J, Semler O, Gilissen C, Li Y, Bolz HJ, Giunta C, ...
https://en.wikipedia.org/wiki/PEDF
Euglobulin lysis timeEuglobulin lysis time
... and to a lesser extent alpha 2-antiplasmin. The euglobulin fraction also contains factor VIII. After precipitation, the ...
https://en.wikipedia.org/wiki/Euglobulin_lysis_time
രക്തം കട്ടപിടിക്കൽ - വിക്കിപീഡിയരക്തം കട്ടപിടിക്കൽ - വിക്കിപീഡിയ
... alpha 2-antiplasmin). പ്ലാസ്മിനെ തടയുന്നു. ആന്റിപ്ലാസ്മിന്റെ അഭാവം ടിഷ്യൂ പ്ലാസ്മിനോജൻ ആക്ടിവേറ്റർ (tissue plasminogen ... പ്ലാസ്മിനോജൻ ആക്ടിവേറ്റർ ഇൻഹിബിറ്റർ-2 (plasminogen activator inhibitor-2) (PAI2). tPA & urokinase (placental PAI)എന്നിവയെ ...
https://ml.wikipedia.org/wiki/രക്തം_കട്ടപിടിക്കൽ
AntithrombinAntithrombin
... such as alpha 1-antichymotrypsin, alpha 2-antiplasmin and Heparin cofactor II. The physiological target proteases of ... Turk B, Brieditis I, Bock SC, Olson ST, Björk I (1997). "The oligosaccharide side chain on Asn-135 of alpha-antithrombin, ... alpha 1-antichymotrypsin and MENT. The conformational change most relevant for Factor IXa and Xa inhibition involves the P14 ... J. 314 (2): 647-653. doi:10.1042/bj3140647. PMC 1217096. PMID 8670081. Bedsted T, Swanson R, Chuang YJ, Bock PE, Björk I, Olson ...
https://en.wikipedia.org/wiki/Antithrombin
Alpha globulinAlpha globulin
α1-antitrypsin Alpha 1-antichymotrypsin Orosomucoid (acid glycoprotein) Serum amyloid A Alpha 1-lipoprotein Haptoglobin Alpha- ... Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions ... The alpha globulins typically have molecular weights of around 93 kDa. ... 2u globulin α2-macroglobulin Ceruloplasmin Thyroxine-binding globulin Alpha 2-antiplasmin Protein C Alpha 2-lipoprotein ...
https://en.wikipedia.org/wiki/Alpha_globulin
Alpha 2-antiplasminAlpha 2-antiplasmin
... (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for ...
https://en.wikipedia.org/wiki/Alpha_2-antiplasmin
Gel electrophoresis of proteinsGel electrophoresis of proteins
The globulins are classified by their banding pattern (with their main representatives): The alpha (α) band consists of two ... α2 - haptoglobin, α2-macroglobulin, α2-antiplasmin, ceruloplasmin. The beta (β) band - transferrin, LDL, complement The gamma ( ... 2, Method and application to human serum proteins". Ann. N. Y. Acad. Sci. 121 (2): 404-427. doi:10.1111/j.1749-6632.1964. ... 199 (2): 223-231. doi:10.1016/0003-2697(91)90094-A. PMID 1812789 Wittig, I.; Braun, H.P.; Schägger, H. (2006). "Blue native ...
https://en.wikipedia.org/wiki/Gel_electrophoresis_of_proteins
عوامل التخثر - ويكيبيدياعوامل التخثر - ويكيبيديا
alpha 2-antiplasmin. Inhibits plasmin منشط بلازمينوجين النسيجي (tPA). Activates plasminogen يوروكيناز. Activates plasminogen ... plasminogen activator inhibitor-2 (PAI2). Inactivates tPA & urokinase (مشيميl PAI) cancer procoagulant. Pathological العامل ...
https://ar.m.wikipedia.org/wiki/عوامل_التخثر
抗體 - 維基百科，自由的百科全書抗體 - 維基百科，自由的百科全書
Feldmann M, Maini R. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?. Annu Rev Immunol. 2001, 19 (1): 163 ... 抗體（antibody），又稱免疫球蛋白（immunoglobulin，簡稱Ig）[1]，是一種主要由漿細胞分泌，被免疫系統用來鑑別與中和外來物質如細菌、病毒等病原體的大型Y形蛋白質，僅被發現存在於脊椎動物的血液等體液中，及其B細胞的細胞膜表面[2][3 ... 2. Y型、
https://zh.wikipedia.org/zh-tw/抗体
AntibodyAntibody
Feldmann M, Maini R (2001). "Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?". Annu Rev Immunol. 19 (1): ... Possible classes of heavy chains in antibodies include alpha, gamma, delta, epsilon, and mu, and they define the antibody's ... Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain ... and Fc regions and the role of N-glycosylation on Fc alpha receptor interactions". J Biol Chem. 273 (4): 2260-2272. doi:10.1074 ...
https://en.wikipedia.org/wiki/Antibody
AlbuminAlbumin
Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin ... A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein, vitamin D-binding ... alpha-fetoprotein, and vitamin D-binding protein gene family". The Journal of Biological Chemistry. 269 (27): 18149-54. PMID ... alpha-fetoprotein, vitamin D-binding protein multigene family". Journal of Molecular Evolution. 29 (4): 344-354. doi:10.1007/ ...
https://en.wikipedia.org/wiki/Albumins
AlbuminAlbumin
Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin ... A number of blood transport proteins are evolutionarily related, including serum albumin, alpha-fetoprotein, vitamin D-binding ... alpha-fetoprotein, and vitamin D-binding protein gene family". The Journal of Biological Chemistry. 269 (27): 18149-54. PMID ...
https://en.wikipedia.org/wiki/Albumin
OrosomucoidOrosomucoid
Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... Orosomucoid (ORM) or alpha-1-acid glycoprotein (α1AGp,[1] AGP or AAG) is an acute phase (acute phase protein) plasma alpha- ... Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five- ... there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, ...
https://en.wikipedia.org/wiki/Orosomucoid
TransferrinTransferrin
Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ... 283 (2): 611-5. doi:10.1042/bj2830611. PMC 1131079. PMID 1315521.. *^ M Ching-Ming Chung (October 1984). "Structure and ... Transferrin has been shown to interact with insulin-like growth factor 2[18] and IGFBP3.[19] Transcriptional regulation of ...
https://en.wikipedia.org/wiki/Transferrin
List of MeSH codes (D12.776)List of MeSH codes (D12.776)
... alpha 1-antitrypsin MeSH D12.776.377.715.085.100 - alpha-macroglobulins MeSH D12.776.377.715.085.118 - antiplasmin MeSH D12.776 ... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ... Retinoid X receptor alpha MeSH D12.776.826.701.500.625 - Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
List of MeSH codes (D12.776.124)List of MeSH codes (D12.776.124)
... alpha 1-antitrypsin MeSH D12.776.124.790.106.100 - alpha-macroglobulins MeSH D12.776.124.790.106.118 - antiplasmin MeSH D12.776 ... alpha-macroglobulins MeSH D12.776.124.790.720.100.500 - pregnancy-associated alpha 2-macroglobulins The list continues at List ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 - immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 - ... immunoglobulin alpha-chains MeSH D12.776.124.790.651.114.619.251 - immunoglobulin d MeSH D12.776.124.790.651.114.619.251.500 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
Fibroblast activation protein, alphaFibroblast activation protein, alpha
... human alpha2 antiplasmin and denatured collagen I and III. NPY, FGF-21 and alpha2 antiplasmin are considered to be ... Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded ... Bae S, Park CW, Son HK, Ju HK, Paik D, Jeon CJ, Koh GY, Kim J, Kim H (September 2008). "Fibroblast activation protein alpha ... Lee KN, Jackson KW, Christiansen VJ, Lee CS, Chun JG, McKee PA (February 2006). "Antiplasmin-cleaving enzyme is a soluble form ...
https://en.wikipedia.org/wiki/Fibroblast_activation_protein,_alpha
LactalbuminLactalbumin
There are alpha and beta lactalbumins; both are contained in milk.. Scientific studies suggest that certain types of ... 2. Influence Of Dietary Proteins On The Immune System Of Mice Bounous G., Kongshavn P.A. J Nutr.Sep; 112(9) :1747-55 (1982) ... 2, 395-402, 2008.. Oxidative stress plays a role in the tumor-cytotoxic effect of cancer chemotherapy and radiotherapy and also ... Serum IL-2 levels began to increase 8 weeks and remained high even after supplement with Immunocal -food had ended. Furthermore ...
https://en.wikipedia.org/wiki/Lactalbumin
Plasminogen activator inhibitor-2Plasminogen activator inhibitor-2
... and nine alpha helices (hA-hI).[6][7] The structure of PAI-2 mutants have been solved, in which the 33-amino acid loop ... Whether PAI-2's physiological function is inhibition of the extracellular protease urokinase and/or whether PAI-2 has ... At least one of PAI-2's physiological functions may involve regulation of adaptive immunity.[5] ... PAI-2's role in apoptosis has been investigated, but current evidence remains inconclusive.[13][17] A recent study suggests PAI ...
https://en.wikipedia.org/wiki/Plasminogen_activator_inhibitor-2
User:JfdwolffUser:Jfdwolff
5-alpha reductase, ADAMTS13, Adipokine, Alpha-1 antitrypsin (T), Alpha 2-antiplasmin, Amyloid beta, Anti-neutrophil cytoplasmic ... Diseases - Achlorhydria, Acute kidney injury, Allergic conjunctivitis, Alpha-1 antitrypsin deficiency (T), Angiodysplasia, ... It has been suggested that I coined "not here to [build] an encyclopedia"[2] ...
https://en.m.wikipedia.org/wiki/User:Jfdwolff
List of diseases (A)List of diseases (A)
Alpha-ketoglutarate dehydrogenase deficiency Alpha-L-iduronidase deficiency Alpha-mannosidosis Alpha-sarcoglycanopathy Alpha- ... drugs antenatal infection Antinolo-Nieto-Borrego syndrome Antiphospholipid syndrome Anti-plasmin deficiency Anti-plasmin ... thalassemia Alpha thalassemia abnormal morphogenesis Alpha-thalassemia mental retardation syndrome Alport syndrome Alport ... totalis Alopecia universalis Alopecia universalis onychodystrophy vitiligo Alpers disease Alpha 1-antitrypsin deficiency Alpha- ...
https://en.wikipedia.org/wiki/List_of_diseases_(A)
Alpha 2-antiplasmin - WikipediaAlpha 2-antiplasmin - Wikipedia
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for ...
https://en.wikipedia.org/wiki/Alpha_2-antiplasmin
alpha-2-antiplasmin ELISA Kits | Biocompare.comalpha-2-antiplasmin ELISA Kits | Biocompare.com
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Natural Human Alpha 2 Antiplasmin protein (ab81750) | AbcamNatural Human Alpha 2 Antiplasmin protein (ab81750) | Abcam
Buy our Natural Human Alpha 2 Antiplasmin protein. Ab81750 is a full length protein produced in Nativesyntheticaly and has been ... Natural Human Alpha 2 Antiplasmin protein. See all Alpha 2 Antiplasmin proteins and peptides. ... Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. APLID is an autosomal recessive ... Serine (or cysteine) proteinase inhibitor, clade F (alpha 2 antiplasmin pigment epithelium derived factor) member 2 ...
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SERPINF2 - Alpha-2-antiplasmin precursor - Homo sapiens (Human) - SERPINF2 gene & proteinSERPINF2 - Alpha-2-antiplasmin precursor - Homo sapiens (Human) - SERPINF2 gene & protein
Alpha-2-antiplasminAdd BLAST. 452. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ... "Amino-acid sequence of human alpha 2-antiplasmin.". Lijnen H.R., Holmes W.E., van Hoef B., Wiman B., Rodriguez H., Collen D.. ... "alpha2-antiplasmin is associated with the progression of fibrosis.". Kanno Y., Kawashita E., Minamida M., Kaneiwa A., Okada K. ... "alpha2-antiplasmin is associated with the progression of fibrosis.". Kanno Y., Kawashita E., Minamida M., Kaneiwa A., Okada K. ...
https://www.uniprot.org/uniprot/P08697
Serpinf2 - Alpha-2-antiplasmin precursor - Mus musculus (Mouse) - Serpinf2 gene & proteinSerpinf2 - Alpha-2-antiplasmin precursor - Mus musculus (Mouse) - Serpinf2 gene & protein
Alpha-2-antiplasminAdd BLAST. 452. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical view. ... "alpha2-antiplasmin is associated with the progression of fibrosis.". Kanno Y., Kawashita E., Minamida M., Kaneiwa A., Okada K. ... "Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling.". Hou Y., Okada K., Okamoto C., ... "Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling.". Hou Y., Okada K., Okamoto C., ...
https://www.uniprot.org/uniprot/Q61247
alpha-2 Antiplasmin - Medical Dictionary online-medical-dictionary.orgalpha-2 Antiplasmin - Medical Dictionary online-medical-dictionary.org
alpha-2 Antiplasmin. A member of the serpin superfamily found in Plasma that inhibits the lysis of Fibrin clots which are ... It is a Glycoprotein, Molecular Weight approximately 70,000 that migrates in the alpha 2 region in Immunoelectrophoresis. It is ...
http://www.online-medical-dictionary.org/definitions-a/alpha-2-antiplasmin.html
Global Alpha-2 Antiplasmin Sales Market Report 2016Global Alpha-2 Antiplasmin Sales Market Report 2016
... of Alpha-2 Antiplasmin in Global market, especially in United States, China, Europe, Japan, focuses on top players in these ... means the sales value of Alpha-2 Antiplasmin This report studies sales (consumption) ... means the sales volume of Alpha-2 Antiplasmin Revenue, ... 1.2 Classification of Alpha-2 Antiplasmin. 1.2.1 Type I. 1.2.2 ... 8.1 Alpha-2 Antiplasmin Key Raw Materials Analysis. 8.1.1 Key Raw Materials. 8.1.2 Price Trend of Key Raw Materials. 8.1.3 Key ...
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Alpha 2 Antiplasmin blocking peptide | GeneTexAlpha 2 Antiplasmin blocking peptide | GeneTex
Alpha 2 Antiplasmin blocking peptide, GTX88657-PEP, Applications: Apuri, Blocking, ELISA; Affinity purification, Blocking, ... Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. ... serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2. ...
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Serpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63) (NBP2-11890): Novus BiologicalsSerpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63) (NBP2-11890): Novus Biologicals
Rat Monoclonal Anti-Serpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63). Validated: WB. Tested Reactivity: Mouse. 100% ... Additional Serpin F2/alpha 2-Antiplasmin Products. Serpin F2/alpha 2-Antiplasmin NBP2-11890 * Serpin F2/alpha 2-Antiplasmin ... Blogs on Serpin F2/alpha 2-Antiplasmin. There are no specific blogs for Serpin F2/alpha 2-Antiplasmin, but you can read our ... Serpin F2/alpha 2-Antiplasmin Antibody (RM0324-2H63) Summary. Immunogen. Mouse SERPINF2 ...
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anti-Alpha 2 Antiplasmin antibody, Internal | GeneTexanti-Alpha 2 Antiplasmin antibody, Internal | GeneTex
Anti-Alpha 2 Antiplasmin pAb (GTX88657) is tested in Human samples. 100% Ab-Assurance. ... alpha-2 antiplasmin, pigment epithelium derived factor), member 2) for ELISA, IHC-P, WB. ... Alpha 2 Antiplasmin antibody, Internal (serpin peptidase inhibitor, clade F ( ... Specifications: Alpha 2 Antiplasmin antibody, Internal. Full Name. serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, ...
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Human Serpin F2/alpha 2-Antiplasmin DuoSet ELISA DY1470-05: R&D SystemsHuman Serpin F2/alpha 2-Antiplasmin DuoSet ELISA DY1470-05: R&D Systems
View alpha 2-Antiplasmin DuoSet ELISA Cat# DY1470-05 details. ... Build a human alpha 2-Antiplasmin ELISA with DuoSet®; 78.1- ... Reviews for Human Serpin F2/alpha 2-Antiplasmin DuoSet ELISA. There are currently no reviews for this product. Be the first to ... Have you used Human Serpin F2/alpha 2-Antiplasmin DuoSet ELISA?. Submit a review and receive an Amazon gift card.. $25/€18/£15 ... Background: Serpin F2/alpha 2-Antiplasmin. The human serpin superfamily consists of at least 35 members that target not only ...
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Recombinant Mouse Serpin F2/alpha 2-Antiplasmin Protein, CF 1239-PI-010: R&D SystemsRecombinant Mouse Serpin F2/alpha 2-Antiplasmin Protein, CF 1239-PI-010: R&D Systems
... alpha 2-Antiplasmin protein (1239-PI) is manufactured by R&D Systems. Reproducible results in inhibition activity assays. Learn ... Have you used Recombinant Mouse Serpin F2/alpha 2-Antiplasmin Protein, CF?. Submit a review and receive an Amazon gift card.. $ ... Reviews for Recombinant Mouse Serpin F2/alpha 2-Antiplasmin Protein, CF. There are currently no reviews for this product. Be ... Background: Serpin F2/alpha 2-Antiplasmin. Serpin F2 is a member of the Serpin superfamily and the primary physiological ...
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2012 Global Alpha-2 Antiplasmin Market Outlook: Test Volume Forecasts by Country and Market Segment2012 Global Alpha-2 Antiplasmin Market Outlook: Test Volume Forecasts by Country and Market Segment
... Date:. April 20, 2012 ... U.K. Alpha-2 Antiplasmin Test Volume Forecasts by Market Segment. U.S.A. Alpha-2 Antiplasmin Test Volume Forecasts by Market ... Germany Alpha-2 Antiplasmin Test Volume Forecasts by Market Segment. Italy Alpha-2 Antiplasmin Test Volume Forecasts by Market ... Japan Alpha-2 Antiplasmin Test Volume Forecasts by Market Segment. Spain Alpha-2 Antiplasmin Test Volume Forecasts by Market ...
https://marketpublishers.com/report/medicine_pharmaceuticals_biotechnology/healthcare_equipment_services/alpha_2_antiplasmin_us_europe_japan_test_volume_forecasts_by_country_n_market_segment.html
Human Alpha 2-Antiplasmin Total Antigen ELISA Kit | Cell SciencesHuman Alpha 2-Antiplasmin Total Antigen ELISA Kit | Cell Sciences
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2019 Cell Sciences, Inc.. ...
https://www.cellsciences.com/human-alpha-2-antiplasmin-total-antigen-elisa-kit
anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody...anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody...
Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody (Alexa Fluor 555) ABIN910642 from ... Itemanti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) ... anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody ... anti-serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) antibody ...
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Bovine SERPINF2 / Alpha-2-Antiplasmin Quant ELISA Kit | Custom | LSBioBovine SERPINF2 / Alpha-2-Antiplasmin Quant ELISA Kit | Custom | LSBio
Alpha-2-Antiplasmin It is a Custom assay which can detect SERPINF2 / Alpha-2-Antiplasmin ... Alpha-2-Antiplasmin ELISA Kit LS-F13885 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative detection of Bovine ... LS-F13885 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Bovine SERPINF2 / Alpha-2- ...
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2016-2020 World Alpha-2 Antiplasmin Testing Market: Ambulatory Centers, Commercial Labs, Hospitals, Physician Offices, POC...2016-2020 World Alpha-2 Antiplasmin Testing Market: Ambulatory Centers, Commercial Labs, Hospitals, Physician Offices, POC...
2016-2020 World Alpha-2 Antiplasmin Testing Market: Ambulatory Centers, Commercial Labs, Hospitals, Physician Offices, POC/ ... 2016-2020 World Alpha-2 Antiplasmin Testing Market: Ambulatory Centers, Commercial Labs, Hospitals, Physician Offices, POC/ ... 2016-2020 World Alpha-2 Antiplasmin Testing Market: Ambulatory Centers, Commercial Labs, Hospitals, Physician Offices, POC/ ... This report presents a detailed analysis of the Alpha-2 Antiplasmin testing market in the US, Europe (France, Germany, Italy, ...
https://www.marketresearch.com/Venture-Planning-Group-v3447/Alpha-Antiplasmin-Testing-Ambulatory-Centers-9900463/
Alpha 2 Antiplasmin, Human Plasma | Athens Research & TechnologyAlpha 2 Antiplasmin, Human Plasma | Athens Research & Technology
Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with ... Gel Scan of Alpha 2 Antiplasmin, Human Plasma. This information is representative of the product ART prepares, but is not lot ... Alpha 2 Antiplasmin, Human Plasma (Coagulation Factor). Buy direct from the manufacturer. Bulk Qty Available. Same day shipping ... Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved ...
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Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged - Innovative ResearchMouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged - Innovative Research
Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged from Innovative Research has been recombinantly produced in ... Product Inquiry for Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged. Name. Email. Phone Number. Message. ... Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged from Innovative Research has been recombinantly produced in ... Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged. IMSA2APRFLAGT100UG Innovative Research ...
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Alpha-2-antiplasminAlpha-2-antiplasmin
Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. ...
https://pharos.nih.gov/idg/targets/SERPINF2
A2AP - Alpha 2 Antiplasmin Antibodies - Affinity Biologicals, Inc.A2AP - Alpha 2 Antiplasmin Antibodies - Affinity Biologicals, Inc.
Alpha 2 Antiplasmin Antibodies - manufactured by Affinity Biologicals - visit our website for more information on our ... alpha-2-Antiplasmin Polyclonal Antibody. View Product. GA2AP-IG - Goat anti human alpha-2-Antiplasmin, purified IgG (5mg vial) ... Description of Alpha 2-Antiplasmin. Alpha 2-Antiplasmin (α2AP), also known as Alpha 2-Plasmin Inhibitor (α2PI), is a member of ... Alpha-2-Antiplasmin Polyclonal Antibody - HRP Conjugated. View Product. GA2AP-HRP - Goat anti human Alpha-2-Antiplasmin, ...
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Alpha2-antiplasmin | definition of alpha2-antiplasmin by Medical dictionaryAlpha2-antiplasmin | definition of alpha2-antiplasmin by Medical dictionary
What is alpha2-antiplasmin? Meaning of alpha2-antiplasmin medical term. What does alpha2-antiplasmin mean? ... Looking for online definition of alpha2-antiplasmin in the Medical Dictionary? alpha2-antiplasmin explanation free. ... alpha2-antiplasmin. alpha2-antiplasmin. /al·pha2-an·ti·plas·min/ (-an″tĭ-plaz´min) see antiplasmin.. alpha2-antiplasmin. the ... Alpha2-antiplasmin , definition of alpha2-antiplasmin by Medical dictionary https://medical-dictionary.thefreedictionary.com/ ...
https://medical-dictionary.thefreedictionary.com/alpha2-antiplasmin
Alpha-2-antiplasmin Heavy Tryptic Peptide StandardAlpha-2-antiplasmin Heavy Tryptic Peptide Standard
Mouse Alpha 2-Antiplasmin Active ELISA Assay | Eagle BioMouse Alpha 2-Antiplasmin Active ELISA Assay | Eagle Bio
The Alpha2-AP ELISA Assay kit is for the quantitative determination of Active Alpha 2-Antiplasmin in mouse plasma by a ... Mouse Alpha 2-Antiplasmin (Alpha2-AP) Active ELISA Assay. $870.00. The Eagle Biosciences Mouse Alpha 2-Antiplasmin (Alpha2-AP) ... Alpha 2 antiplasmin (Alpha2-AP) is the major circulating inhibitor of plasmin, and it has a role in the regulation of ... Home / All Products / Assay Kits / Veterinarian Assay Kits / Mouse Alpha 2-Antiplasmin (Alpha2-AP) Active ELISA Assay. ...
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Gentaur Molecular :Meridian Life Science \ Human Alpha 2 Antiplasmin \ A50112HGentaur Molecular :Meridian Life Science \ Human Alpha 2 Antiplasmin \ A50112H
Human Alpha 2 Antiplasmin \ A50112H for more molecular products just contact us ... Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha). [HBB] Hemoglobin subunit beta (Beta-globin) ( ... WP1047: TNF-alpha NF-kB Signaling Pathway. WP1120: Ovarian Infertility Genes. WP1163: TNF-alpha NF-kB Signaling Pathway. WP1209 ... WP1835: Interferon alpha/beta signaling. WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. WP1963: The effect ...
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Antiplasmin, Activity, PlasmaAntiplasmin, Activity, Plasma
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Alpha-2-Antiplasmin, Activity. 2. Factor VIII Activity, ReFacto. 3. Plasmacup SC. 4. Rapid Plasma Reagin (RPR) Sset. 5. Macro- ... 2, 2017 Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the ...
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Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of...Protein regions important for plasminogen activation and inactivation of alpha2-antiplasmin in the surface protease Pla of...
The mature alpha-Pla of 292 amino acids was processed into beta-Pla by an autoprocessing cleavage at residue K262, and residues ... alpha2-antiplasmin, and the bacteria were found to inactivate alpha2-antiplasmin. In contrast, only poor plasminogen activation ... had no detectable effect on plasminogen activation or cleavage of alpha2-antiplasmin. Cleavage of alpha2-antiplasmin and ... We propose that inactivation of alpha2-antiplasmin by Pla of Y. pestis promotes uncontrolled proteolysis and contributes to the ...
https://pubmed.ncbi.nlm.nih.gov/11401715/?dopt=Abstract
The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm - PubMedThe alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm - PubMed
The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm Katherine I Bridge 1 , Fraser ... The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm Katherine I Bridge et al. Thromb ... Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal. Lee KN, Jackson KW, Christiansen VJ, Chung KH, ... Katherine I Bridge 1 , Fraser Macrae 2 , Marc A Bailey 3 , Anne Johnson 1 , Helen Philippou 2 , D Julian A Scott 1 , Robert A S ...
https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cluster&id=909
CIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGENCIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGEN
... Author. NILSSON T; ... 202-ANTIPLASMIN%20AND%20ITS%20INTERACTIONS%20WITH%20PLASMIN%20AND%20PLASMINOGEN&rft.date=1982&rft.aulast=NILSSON&rft.aufirst=T& ... "CIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGEN;s:9:\u0000*\u0000jtitle ... "CIRCULAR DICHROISM STUDIES ON ALPHA 2-ANTIPLASMIN AND ITS INTERACTIONS WITH PLASMIN AND PLASMINOGEN;s:8:\u0000*\u0000place ...
https://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=PASCAL83X0361555
The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm. - PubMed - NCBIThe alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm. - PubMed - NCBI
The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm.. Bridge KI1, Macrae F2, Bailey MA3 ... 2. Theme Thrombosis, Division of Cardiovascular and Diabetes Research, Leeds institute for Genetics, Health and Therapeutics, ... Caucasian subjects ≥ 55 years (602 AAA patients and 490 matched controls) were genotyped for four polymorphisms (α-2- ... antiplasmin α2AP Arg6Trp and Arg407Lys, Thrombin-activatable fibrinolysis inhibitor TAFI Thr325Ile and tissue plasminogen ...
https://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=112083
FibrinolysisAlpha2-antiplasminSERPINF2A2APAntibodyDeficiencyFibrinogenMouse Alpha 2 AntiplasmAntigenAntibodiesProteinCoagulationPlasmaProteaseAntithrombin IIISerpinPeptideELISAClotsThrombosisInhibitionInactivateConcentrationCleavageUrokinaseDiagnosisGlycoproteinEnzymeHumansDecentralizationSevereThrombusConcentrations
Fibrinolysis7
  • α 2 AP also acts to regulate fibrinolysis by binding to the lysine binding sites on plasminogen thus competitively inhibiting plasminogen binding to fibrin. (affinitybiologicals.com)
  • Alpha 2 antiplasmin (Alpha2-AP) is the major circulating inhibitor of plasmin, and it has a role in the regulation of intravascular fibrinolysis. (eaglebio.com)
  • Caucasian subjects ≥ 55 years (602 AAA patients and 490 matched controls) were genotyped for four polymorphisms (α-2-antiplasmin α2AP Arg6Trp and Arg407Lys, Thrombin-activatable fibrinolysis inhibitor TAFI Thr325Ile and tissue plasminogen activator tPA 7351C→T). DNA was extracted from blood, and genotype identified using real time PCR. (cdc.gov)
  • The ELT measures fibrinolysis by clotting the euglobulin fraction (primarily the important fibrinolytic factors fibrinogen , PAI-1 , tPA , alpha 2-antiplasmin , and plasminogen ) from plasma and then observing the time required for clot dissolution. (wikipedia.org)
  • Three out of nine proteins identified to associate with HDL-4-Apo A-2 are involved in the regulation of fibrinolysis, namely, the plasmin regulator, alpha-2-antiplasmin, and two major components of the kallikrein-kinin pathway (coagulation factor XI and prekallikrein), and their physical presence in the HDL-4 subfraction was confirmed. (bmj.com)
  • Under normal conditions, the fibrinolytic process is localized on the fibrin clots because alpha 2 -antiplasmin and the plasminogen activator inhibitors prevent fibrinolysis from spreading. (labcorp.com)
  • We measured a battery of markers of coagulation (fibrinogen, factor VII activity, factor XIa-alpha-1-antitrypsin, activated protein C-resistance), fibrinolysis (tissue-type plasminogen activator [tPA], plasminogen activator inhibitor-1 [PAI-1], D-dimer, plasmin-alpha-2-antiplasmin), and inflammation (C-reactive protein, E-selectin). (usda.gov)
Alpha2-antiplasmin10
  • Decreased levels of Alpha2 antiplasmin may play an important role in the increased capacity of the fibrinolytic function and may be beneficial in the treatment of thrombotic diseases, acute pulmonary embolism, and hepatic repair. (eaglebio.com)
  • Pla-expressing Y. pestis and recombinant Escherichia coli formed active plasmin in the presence of the major human plasmin inhibitor, alpha2-antiplasmin, and the bacteria were found to inactivate alpha2-antiplasmin. (nih.gov)
  • In contrast, only poor plasminogen activation and no cleavage of alpha2-antiplasmin was observed with recombinant bacteria expressing the homologous gene ompT from E. coli. (nih.gov)
  • Analysis of the hybrid molecules suggested a critical role of L3 and L4 in the substrate specificity of Pla towards plasminogen and alpha2-antiplasmin. (nih.gov)
  • Prevention of autoprocessing of Pla, however, had no detectable effect on plasminogen activation or cleavage of alpha2-antiplasmin. (nih.gov)
  • Cleavage of alpha2-antiplasmin and plasminogen activation were influenced by residue R211 in L4 as well as by unidentified residues in L3. (nih.gov)
  • We propose that inactivation of alpha2-antiplasmin by Pla of Y. pestis promotes uncontrolled proteolysis and contributes to the invasive character of plague. (nih.gov)
  • Plasmin, tissue plasminogen activator (tPA), and urokinase plasminogen activator (uPA) activity, plasminogen activator inhibitor 1 (PAI-1), and alpha2-antiplasmin (alpha2AP) antigen were measured in the AAA wall and juxtamural and luminal aspects of intraluminal thrombus in 18 patients. (biomedsearch.com)
  • Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent. (biomedsearch.com)
  • Inhibition of Borrelia burgdorferi-bound fibrinolytic enzymes by alpha2-antiplasmin, PAI-1 and PAI-2. (nih.gov)
SERPINF22
  • Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]. (abcam.com)
  • LS-F13885 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Bovine SERPINF2 / Alpha-2-Antiplasmin. (lsbio.com)
A2AP4
  • Mouse Alpha 2 Antiplasmin (A2Ap) Purified Recombinant FLAG Tagged from Innovative Research has been recombinantly produced in insect cells and purified using affinity chromatography. (innov-research.com)
  • Affinity Biologicals, Inc. manufactures a broad range of A2AP - Alpha 2 Antiplasmin Antibodies which can be found in the listing below. (affinitybiologicals.com)
  • Our A2AP - Alpha 2 Antiplasmin Antibodies are excellent for use in immunoassays where high sensitivity is required and are frequently the preferred reagent for immunopreciptaion techniques and activity neutralization assays. (affinitybiologicals.com)
  • Affinity's A2AP - Alpha 2 Antiplasmin Antibodies are manufactured for use in research applications. (affinitybiologicals.com)
Antibody8
  • There are currently no images for Serpin F2/alpha 2-Antiplasmin Antibody (NBP2-11890). (novusbio.com)
  • IHC-P analysis of human liver using GTX88657 Alpha 2 Antiplasmin antibody, Internal. (genetex.com)
  • WB analysis of human duodenum lysate using GTX88657 Alpha 2 Antiplasmin antibody, Internal. (genetex.com)
  • Further information about each individual Alpha 2 Antiplasmin Antibody is available by following the associated links. (affinitybiologicals.com)
  • Unbound a-2-antiplasmin is removed by washing and an anti-a-2-antiplasmin primary antibody is added. (eaglebio.com)
  • The bound antibody, which is proportional to the original active a-2-antiplasmin present in the samples, is then reacted with the horseradish peroxidase-conjugated secondary antibody. (eaglebio.com)
  • Human Alpha 2 Antiplasmin antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Human Alpha 2 Antiplasmin. (antibody-antibodies.com)
  • 2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab) 2 , IgG, scFv and different Fc and non-Fc conjugates per customer request. (abnova.com)
Deficiency5
  • Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. (genetex.com)
  • Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. (athensresearch.com)
  • This study concerns a case of congenital homozygous deficiency in alpha 2-antiplasmin associated with a severe hemorrhagic diathesis. (ashpublications.org)
  • p less than 0.01), indicating systemic consequences of the deficiency and reduced binding (+/- 50%) of alpha 2- antiplasmin to fibrin. (ashpublications.org)
  • Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. (wikipedia.org)
Fibrinogen5
  • PLA 2 then modifies the integrin membrane glycoprotein IIb/IIIa , increasing its affinity to bind fibrinogen . (wikipedia.org)
  • Supernatants were stored at -80°C, then thawed for measurement of fibrinogen concentration, plasminogen activity, antiplasmin activity, and D-dimer concentration. (nih.gov)
  • 0.0001), whereas plasminogen activator inhibitor-2, tissue-type plasminogen activator/plasminogen activator inhibitor complexes and fibrinogen/fibrin degradation products did not differ between groups. (cun.es)
  • SMRX-11 demonstrated superior fibrinogen sparing compared to tPA with minimal consumption of alpha-2 antiplasmin relative to native SK. (ahajournals.org)
  • During the incubation of BM 06.022 in plasma, plasmin was generated dose-dependently as revealed by varying degrees of α2-antiplasmin consumption and fibrinogen degradation. (tudelft.nl)
Mouse Alpha 2 Antiplasm2
  • The Eagle Biosciences Mouse Alpha 2-Antiplasmin (Alpha2-AP) Active ELISA Assay kit is for the quantitative determination of Active Alpha 2-Antiplasmin (Alpha2-AP) in mouse plasma by a microplate enzyme immunoassay (ELISA). (eaglebio.com)
  • This Mouse Alpha-2-antiplasmin (Alpha2-AP) Active ELISA Assay kit is for the quantitative determination of active a-2-antiplasmin in mouse plasma. (eaglebio.com)
Antigen1
  • Plasminogen activity and antigen, euglobulin fibrinolytic activity, tissue-type plasminogen activator activity and antigen urokinase-type plasminogen activator antigen, plasminogen activator inhibitor-1 activity and antigen, plasminogen activator inhibitor-2 antigen, tissue-type plasminogen activator/plasminogen activator inhibitor complexes, alpha 2-antiplasmin, histidine-rich glycoprotein, and fibrinogen/fibrin degradation products were measured in blood samples taken from the umbilical vein of 100 healthy full-term newborns. (cun.es)
Antibodies1
  • These complexes could be completely precipitated with antibodies against C1-inactivator, α2-antiplasmin and α1-antitrypsin. (tudelft.nl)
Protein5
  • The primary target enzyme for α 2 AP is plasmin, but α 2 AP also acts as secondary or "backup" inhibitor of activated FXI, activated Protein C and trypsin. (affinitybiologicals.com)
  • The calcium activates protein kinase C , which, in turn, activates phospholipase A 2 (PLA 2 ). (wikipedia.org)
  • Including the spread, diets averaged 34.6 en% fat and 15.5 en% protein. (usda.gov)
  • Also named as "alpha 2-U globulin," "alpha 2 euglobulin " is a rat protein synthetized in the liver, excreted via the kidneys and reabsorbed by up to 60% by the proximal tubule cells [58]. (thefreedictionary.com)
  • Further, it was supported by a series of animal studies showing inhibition of atherosclerosis in cholesterol-fed rabbits after HDL infusion [ 2 ] and in transgenic mice overexpressing apolipoprotein A-I (apoA-I) [ 3 ], which is the major protein component of HDL particles. (mdpi.com)
Coagulation1
  • Coagulation testing in general, and Alpha-2 Antiplasmin testing specifically, will become more standardized, offering opportunities for quality control products and services. (marketpublishers.com)
Plasma10
  • Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. (athensresearch.com)
  • About 30% of α 2 AP present in plasma is partially degraded and lacks a peptide in the carboxyl region that contains the plasminogen-binding site. (affinitybiologicals.com)
  • It has been determined in laboratory testing that mouse plasma contains approximately 300 µg/ml Alpha-2-antiplasmin. (eaglebio.com)
  • Functionally active Alpha-2-antiplasmin present in plasma reacts with plasmin that has been coated and dried on a microtiter plate. (eaglebio.com)
  • Except for alpha 2- antiplasmin, all protease inhibitors showed normal plasma values. (ashpublications.org)
  • Among the 37 family members studied, a separate group of 16 individuals (including the father and mother of the propositus) with approximately one-half normal plasma levels of alpha 2-antiplasmin both functionally (59% +/- 6%) and immunologically 48% +/- 8%) was discovered. (ashpublications.org)
  • It is concluded that not only the absence of alpha 2-antiplasmin but also a reduction in its plasma level to +/- 60% of normal may predispose to a hemorrhagic diathesis. (ashpublications.org)
  • 2-antiplasmin, all protease inhibitors showed normal plasma values. (tudelft.nl)
  • In conclusion, BM 06.022 at therapeutic concentrations in plasma was inactivated by C1-inactivator, α2-antiplasmin and α1-antitrypsin. (tudelft.nl)
  • Therapeutic consequences for the use of ESDEP in orthotopic liver transplantation are discussed in view of an increased incidence of hyperfibrinolysis caused by reduced levels of alpha(2)-antiplasmin in the solvent/detergent-treated plasma. (eur.nl)
Protease7
  • Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. (wikipedia.org)
  • Serpin F2 is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots (1, 2). (rndsystems.com)
  • Ocriplasmin is quickly inactivated by protease inhibitor α2-antiplasmin or α2-macroglobulin. (drugbank.ca)
  • Thrombin has both extracellular proteolysis and cell mediated functions thorough the protease-activated receptor 2. (nii.ac.jp)
  • We analyzed the roles of protease-activated receptor 2 and aquaporin on the brain edema using in vivo model of brain injury and in vitro model of cell cultures. (nii.ac.jp)
  • Using real-time RT-PCR, we quantitatively evaluated mRNAs of protease-activated receptor 2 and aquaporin. (nii.ac.jp)
  • We could not find the definitive roles of protease-activated receptor 2 on the brain edema. (nii.ac.jp)
Antithrombin III1
  • During recovery from a hemorrhagic episode, signs of previous consumption of antithrombin III, alpha 2-macroglobulin, factor XIII, and inter-alpha- trypsin inhibitor were noted. (ashpublications.org)
Serpin2
  • This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human Serpin F2 / alpha 2-Antiplasmin. (rndsystems.com)
  • Alpha 2-Antiplasmin (α 2 AP), also known as Alpha 2-Plasmin Inhibitor (α 2 PI), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of the enzyme plasmin in blood. (affinitybiologicals.com)
Peptide2
  • Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH 2 (Catalog # ES002 ). (rndsystems.com)
  • METHODS: A bimodal CA was synthesized by coupling gadolinium-diethylene triamine pentaacetic acid and rhodamine to an alpha(2)-antiplasmin-based peptide. (biomedsearch.com)
ELISA1
  • Your search returned 203 alpha-2-antiplasmin ELISA ELISA Kit across 11 suppliers. (biocompare.com)
Clots1
  • Alpha 2-antiplasmin blocks the activity of plasmin, which is a substance in the blood that helps dissolve blood clots. (merckmanuals.com)
Thrombosis1
  • The Coamatic® Plasmin Inhibitor kit has been evaluated regarding specificity and compared with six commercially available plasmin inhibitor (also denoted a2-antiplasmin) kits and with the manual Immediate Plasmin Inhibition Test (IPIT) method, the reference method within the framework of the European Concerted Action against Thrombosis and Disabilities. (tudelft.nl)
Inhibition5
  • Inhibition of these enzymes by α 2 AP occurs through proteolytic cleavage after Arg 364 with subsequent rapid formation of a stable, inactive 1:1 enzyme-α 2 AP complex. (affinitybiologicals.com)
  • This form of α 2 AP (~65 kDa) has a reduced rate of plasmin inhibition and has been referred to as the "slow form" of α 2 AP. (affinitybiologicals.com)
  • With the immediate plasmin inhibition test (synthetic substrate), only 2% of normal functional inhibition was detected, while no reaction with monospecific antisera for alpha 2-antiplasmin was observed. (ashpublications.org)
  • Differential inhibition of soluble and cell surface receptor-bound single-chain urokinase by plasminogen activator inhibitor type 2. (nih.gov)
  • The roles of alpha 2-antiplasmin and plasminogen activator inhibitor 1 (PAI-1) in the inhibition of clot lysis. (nih.gov)
Inactivate1
  • Alpha 2-antiplasmin and alpha 2-macroglobulin inactivate plasmin. (wikipedia.org)
Concentration2
  • The amount of color development is directly proportional to the concentration of active Alpha 2-antiplasmin in the sample. (eaglebio.com)
  • Use a concentration of 0.5 - 2 µg/ml. (abcam.com)
Cleavage1
  • The mature alpha-Pla of 292 amino acids was processed into beta-Pla by an autoprocessing cleavage at residue K262, and residues important for the self-recognition of Pla were identified. (nih.gov)
Urokinase1
  • t-PA and urokinase are themselves inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2 (PAI-1 and PAI-2). (wikipedia.org)
Diagnosis1
  • After the diagnosis was made, treatment with tranexamic acid (4 daily doses of 1 g) was effective for about 2 yr. (ashpublications.org)
Glycoprotein1
  • It is a Glycoprotein , Molecular Weight approximately 70,000 that migrates in the alpha 2 region in Immunoelectrophoresis . (online-medical-dictionary.org)
Enzyme2
  • 2. A medication, hormone, or other intercellular messenger that binds and blocks the cellular receptor or target enzyme of another agent. (thefreedictionary.com)
  • [2] Its main enzyme plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other proteases or by the kidney and liver . (wikipedia.org)
Humans1
  • [2] The system in humans has been the most extensively researched and is the best understood. (wikipedia.org)
Decentralization1
  • Moreover, the continuing contraction of the hospital system and technological advances will facilitate decentralization of the Alpha-2 Antiplasmin testing closer to the patient, creating additional opportunities and challenges for suppliers. (marketresearch.com)
Severe1
  • 2-antiplasmin associated with a severe hemorrhagic diathesis. (tudelft.nl)
Thrombus5
  • OBJECTIVES: We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA). BACKGROUND: Thrombus formation plays a central role in several vascular diseases. (biomedsearch.com)
  • During the early phases of thrombus formation, activated factor XIII (FXIIIa) covalently cross-links alpha(2)-antiplasmin to fibrin, indicating the potential of alpha(2)-antiplasmin-based CAs in the detection of early thrombus formation. (biomedsearch.com)
  • Immunohistochemistry was performed on human pulmonary thromboemboli sections to determine the presence of alpha(2)-antiplasmin and FXIII in different thrombus remodeling phases. (biomedsearch.com)
  • RESULTS: In vitro-generated thrombi exposed to the alpha(2)-antiplasmin-based CA showed hyperintense magnetic resonance signal intensities at the thrombus edge. (biomedsearch.com)
  • The administration of CA in vivo within seconds after inducing thrombus formation increased contrast-to-noise ratios (CNRs 2.28 +/- 0.39, n=6) at the site of thrombus formation compared with the control CA (CNRs -0.14 +/- 0.55, p = 0.003, n = 6) and alpha(2)-antiplasmin-based CA administration 24 to 48 h after thrombus formation (CNRs 0.11 +/- 0.23, p = 0.006, n = 6). (biomedsearch.com)
Concentrations1
  • Clotting analysis of the patients revealed small alpha(2)-antiplasmin concentrations because of the solvent/detergent process. (eur.nl)
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