alpha 1-Antichymotrypsin: Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.Serine Proteinase Inhibitors: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.Trypsin Inhibitors: Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.alpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Hypopharynx: The bottom portion of the pharynx situated below the OROPHARYNX and posterior to the LARYNX. The hypopharynx communicates with the larynx through the laryngeal inlet, and is also called laryngopharynx.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Larynx: A tubular organ of VOICE production. It is located in the anterior neck, superior to the TRACHEA and inferior to the tongue and HYOID BONE.Hypopharyngeal Neoplasms: Tumors or cancer of the HYPOPHARYNX.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Laryngeal Neoplasms: Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.Mouth Neoplasms: Tumors or cancer of the MOUTH.Physicians: Individuals licensed to practice medicine.Judgment: The process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation.Carcinoma, Basal Cell: A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)Physiology: The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.Educational Measurement: The assessing of academic or educational achievement. It includes all aspects of testing and test construction.Anatomy: A branch of biology dealing with the structure of organisms.Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.Teaching: The educational process of instructing.Codon, Initiator: A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.Curriculum: A course of study offered by an educational institution.Students, Pharmacy: Individuals enrolled in a school of pharmacy or a formal educational program leading to a degree in pharmacy.Telepathology: Transmission and interpretation of tissue specimens via remote telecommunication, generally for the purpose of diagnosis or consultation but may also be used for continuing education.Problem-Based Learning: Instructional use of examples or cases to teach using problem-solving skills and critical thinking.Ericaceae: The heath plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida that are generally shrubs or small trees. Leaves are alternate, simple, and leathery; flowers are symmetrical with a 4- or 5-parted corolla of partly fused petals.BrazilMedicine in Literature: Written or other literary works whose subject matter is medical or about the profession of medicine and related areas.Helminthiasis, Animal: Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.National Institute of Child Health and Human Development (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. It now conducts and supports research on all stages of human development. It was established in 1962.Asteraceae: A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.Chrysanthemum: A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.Machado-Joseph Disease: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)Numismatics: Study of coins, tokens, medals, etc. However, it usually refers to medals pertaining to the history of medicine.Lobomycosis: A chronic, fungal, subcutaneous infection endemic in rural regions in South America and Central America. The causal organism is Lacazia labol.Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Science: The study of natural phenomena by observation, measurement, and experimentation.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Social Sciences: Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.Developmental Biology: The field of biology which deals with the process of the growth and differentiation of an organism.Literature, ModernProstate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.History, 20th Century: Time period from 1901 through 2000 of the common era.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.History, 19th Century: Time period from 1801 through 1900 of the common era.Product Labeling: Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.Dust: Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)Prostatic Hyperplasia: Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Epitopes: Sites on an antigen that interact with specific antibodies.

Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease. (1/204)

BACKGROUND: The first-pass metabolism of foreign compounds in the lung is an important protective mechanism against oxidative stress. We investigated whether polymorphisms in the gene for microsomal epoxide hydrolase (mEPHX), an enzyme involved in this protective process, had any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease (COPD) and emphysema. METHODS: We designed PCR-based genotyping assays to detect variant forms of mEPHX that confer slow and fast activity. We used these assays to screen 203 blood-donor controls and groups of patients with asthma (n = 57), lung cancer (n = 50), COPD (n = 68), and emphysema (n = 94), who were attending specialised clinics in Edinburgh, UK. FINDINGS: The proportion of individuals with innate slow mEPHX activity (homozygotes) was significantly higher in both the COPD group and the emphysema group than in the control group (COPD 13 [19%] vs control 13 [6%]; emphysema 21 [22%] vs 13 [6%]). The odds ratios for homozygous slow activity versus all other phenotypes were 4.1 (95% CI 1.8-9.7) for COPD and 5.0 (2.3-10.9) for emphysema. INTERPRETATION: Genetic polymorphisms in xenobiotic enzymes may have a role in individual susceptibility to oxidant-related lung disease. Epoxide derivatives of cigarette-smoke components may be the cause of some of the lung damage characteristics of these diseases.  (+info)

Giardia intestinalis is unlikely to be a major cause of the poor growth of rural Gambian infants. (2/204)

Parasite-specific plasma immunoglobulins have been used to indicate the presence of Giardia intestinalis infection in 60 infants living in a rural area of The Gambia. Infants were studied longitudinally between 2 and 8 mo of age. The median age for first exposure to G. intestinalis was between 3 and 4 mo, and by 8 mo all but 3 infants (95%) showed a positive titer on at least one occasion. Raised Giardia-specific IgM titers were associated with reduced weight gain in the 2 wk preceding a positive titer, but catch-up growth occurred in the following 2 wk. IgM antibody titers were also positively associated with intestinal permeability (lactulose/mannitol ratio), urinary lactose excretion, plasma concentrations of alpha1-antichymotrypsin and total IgM, IgA and IgG immunoglobulins. However, infant growth over the whole 6-mo period (i.e., between 2 and 8 mo of age) was not related to mean Giardia-specific antibody titers, nor the time of first exposure to the parasite. The data suggest that giardiasis in these very young breast-fed children occurs as a mild, acute disease, and its presence could not explain the marked, long-term growth faltering observed in many of the subjects.  (+info)

Anti-free prostate-specific antigen monoclonal antibody epitopes defined by mimotopes and molecular modeling. (3/204)

BACKGROUND: Prostate-specific antigen (PSA) is an important marker for the diagnosis and management of prostate cancer, and the free PSA/total PSA ratio has been shown to be efficient for distinguishing prostate cancer from benign prostatic hyperplasia. We report here the characterization of seven mouse monoclonal antibodies (mAbs) and the partial localization of two conformational epitopes identified by anti-free PSA mAbs. METHODS: The mAbs were studied by competition and sandwich assays, and the epitope localization of the two anti-free PSA mAbs (6C8D8 and 5D3D11) was performed using phage displayed peptide libraries and molecular modeling. RESULTS: The seven mAbs were classified into three groups according to their recognition specificities and their ability to inhibit the enzymatic activity of PSA and the formation of PSA-alpha1-antichymotrypsin (ACT) complex. Among the anti-free PSA mAb group, 6C8D8 recognized the phage displayed peptide RKLRPHWLHFHPVAV, two parts of which presented similarities with two regions distant on the PSA sequence but joined in the tridimensional structure. mAb 5D3D11 recognized the peptide DTPYPWGWLLDEGYD, which is similar to a PSA region located on the board of the groove containing the PSA enzymatic site. Both epitopes were located in the theoretical ACT binding site described previously. Moreover, these mAbs were able to inhibit the enzymatic activity of PSA. CONCLUSIONS: These epitope localizations are in agreement with the ability of both mAbs to inhibit enzymatic activity and ACT fixation. The results presented here could bring information for the generation of clinically relevant PSA assays.  (+info)

Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2. (4/204)

BACKGROUND: Human glandular kallikrein (hK2) is a serine protease that has 79% amino acid identity with prostate-specific antigen (PSA). Both free hK2 and hK2 complexed to alpha1-antichymotrypsin (ACT) are present in the blood in low concentrations. We wished to measure hK2 in serum with limited contribution from hK2-ACT for the results. METHODS: We developed an automated assay for hK2 with use of a select pair of monoclonal antibodies. The prototype assay was implemented on a Beckman Coulter ACCESS(R) analyzer. RESULTS: The detection limit of the assay was 1.5 ng/L, the "functional sensitivity" (day-to-day CV <15%) was <4 ng/L, cross-reactivity with PSA and PSA-ACT was negligible, and cross-reactivity with hK2-ACT was 2%. After surgical removal of prostate glands, serum hK2 was <7 ng/L and was <15 ng/L in most healthy women. The median serum concentration of hK2 in healthy men without prostate cancer was 26 ng/L. The median concentration of hK2 was 72 ng/L for men having prostate cancer with lower Gleason scores compared with 116 ng/L for men with more advanced cancer. The concentration of hK2 correlated weakly with PSA, with the mean hK2 concentrations generally 30- to 80-fold lower than PSA concentrations. CONCLUSION: The availability of a robust, high sensitivity automated assay for hK2 should facilitate further investigations of the role of hK2 measurements in the management of patients with prostate disease.  (+info)

Measurement of the complex between prostate-specific antigen and alpha1-protease inhibitor in serum. (5/204)

BACKGROUND: Prostate-specific antigen (PSA) occurs in serum both free and in complex with protease inhibitors. The complex with alpha1-antichymotrypsin (ACT) is the major form in serum, and the proportion of PSA-ACT is higher in prostate cancer (PCa) than in benign prostatic hyperplasia (BPH). PSA also forms a complex with alpha1-protease inhibitor (API) in vitro, and the PSA-ACT complex has been detected in serum from patients with prostate cancer. The aim of the present study was to develop a quantitative method for the determination of PSA-API and to determine the serum concentrations in patients with PCa and BPH. METHODS: The assay for PSA-API utilizes a monoclonal antibody to PSA as capture and a polyclonal antibody to API labeled with a Eu-chelate as a tracer. For calibrators, PSA-API formed in vitro was used. Serum samples were obtained before treatment from 82 patients with PCa, from 66 patients with BPH, and from 22 healthy females. RESULTS: The concentrations of PSA-API are proportional to the concentrations of total PSA. PSA-API comprises 1.0-7.9% (median, 2.4%) of total immunoreactive PSA in PCa and 1.3-12.2% (median, 3.6%) in BPH patients with serum PSA concentrations >4 microgram/L. In patients with 4-20 microgram/L total PSA, the proportion of PSA-API serum is significantly higher in BPH (median, 4.1%) than in PCa (median, 3. 2%; P = 0.02). CONCLUSIONS: The proportion of PSA-API in serum is lower in patients with PCa than in those with BPH. These results suggest that PSA-API is a potential adjunct to total and free PSA in the diagnosis of prostate cancer.  (+info)

Antichymotrypsin interaction with chymotrypsin. Intermediates on the way to inhibited complex formation. (6/204)

Serpins form enzymatically inactive covalent complexes (designated E*I*) with their target proteinases, corresponding most likely to the acyl enzyme that resembles the normal intermediate in substrate turnover. Formation of E*I* involves large changes in the conformation of the reactive center loop (residues P17 to P9') and of the serpin molecule in general. The "hinge" region of the reactive center loop, including residues P10-P14, shows facile movement in and out of beta-sheet A, and this movement appears to be crucial in determining whether E*I* is formed (the inhibitor pathway) or whether I is rapidly hydrolyzed to I* (the substrate pathway). Here, we report stopped-flow and rapid quench studies investigating the pH dependence of the conversion of the alpha1-antichymotrypsin.alpha-chymotrypsin encounter complex, E.I, to E*I*. These studies utilize fluorescent derivatives of cysteine variants of alpha1-antichymotrypsin at the P11 and P13 residues. Our results demonstrate three identifiable intermediates, EIa, EIb, and EIc, between E.I and E*I* and permit informed speculation regarding the nature of these intermediates. Partitioning between inhibitor and substrate pathways occurs late in the process of E*I* formation, most likely from a species occurring between EIc and E*I*.  (+info)

Comparative study of assays for prostate-specific antigen molecular forms. (7/204)

BACKGROUND: The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. However, the correlation among the values of serum free PSA or PSA-ACT obtained in various assays remains unclear. METHODS: Serum free PSA and PSA-ACT values were detected with the following assays: Hybritech, DPC, EIKEN, Abbott, Roche and Can-Ag for free PSA and Dainippon, Chugai, EIKEN and Bayer for PSA-ACT. The data obtained with each assay were compared with Hybritech (free PSA) and Dainippon (PSA-ACT) as standards. RESULTS: The free PSA data obtained with the Hybritech, EIKEN, Abbott and Can-Ag kits were similar. The values obtained with the DPC and Roche kits showed a linear regression of y = ax + b with those obtained with the Hybritech, with a b value of zero and an a value of 1.20 and 1.57, respectively. The serum PSA-ACT values detected with the Dainippon and Chugai kits were identical. The equation for converting the data obtained with the EIKEN kits to the Dainippon value was 0.7636 x (EIKEN) + 0.1381. CONCLUSIONS: Serum free PSA and PSA-ACT values obtained with various assays were not necessarily the same. Some kits for the assay of free PSA and PSA-ACT gave the same serum values. The free PSA values obtained with the other kits could be converted using appropriate equations. The gamma-Sm values showed wide variations and were not considered suitable as a measurement of free PSA.  (+info)

Effect of the ratio of free to total prostate-specific antigen on interassay variability in proficiency test samples. (8/204)

BACKGROUND: Up to sevenfold differences were observed between total prostate-specific antigen (PSA) methods for New York State Proficiency Test samples prepared with seminal fluid PSA in human female serum. Because the PSA was mainly in its free form under these conditions, we wanted to determine whether a defined mixture of free and complexed PSA would reduce the interassay differences. METHODS: We prepared a series of five solutions of 60 g/L bovine serum albumin with 10 microgram/L total PSA consisting of varied proportions of free, noncomplexible PSA, and alpha(1)-antichymotrypsin (ACT)-complexed PSA from 0% to 100%. Two hundred seventy laboratories measured the total PSA in these samples, and 16 laboratories also analyzed the samples for free PSA. The results were used to calculate free/total PSA ratios. RESULTS: Interassay CVs for total PSA measurements were approximately 7% at 10-15% free PSA but became gradually larger as the free/total PSA ratio increased. Measured free-PSA concentrations were similar within each sample (mean CV, 12%), and the results were relatively independent of the proportion of free PSA in the samples. Twofold discrepancies between actual and expected ratios were observed with some methods at 100% free PSA and to a lesser degree at 30% free PSA. At 100% free PSA, the relatively higher total-PSA values measured by nonequimolar methods yielded low free/total PSA ratios of 50-60%. In contrast, the lower total PSA values obtained by equimolar methods yielded ratios close to the expected 100%. CONCLUSIONS: Preparing proficiency test samples with a 10:90 mixture of free, noncomplexible PSA:PSA-ACT is a viable alternative to the use of seminal fluid PSA. Furthermore, the method used to measure total PSA may have a substantial impact on the calculated proportion of free PSA and hence may have clinical relevance.  (+info)

*Alpha-1 antitrypsin

"Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin". Biochemical Society ... Recombinant alpha-1 antitrypsin is not yet available for use as a drug but is under investigation as a therapy for alpha-1 ... Alpha-1-antitrypsin or α1-antitrypsin (A1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in ... The alpha region can be further divided into two sub-regions, termed "1" and "2". Alpha-1 antitrypsin is the main protein of ...

*Alpha 1-antichymotrypsin

... (symbol α1AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin ... Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in ... Alpha-1 antitrypsin, another serpin that is analogous for protecting the body from excessive effects of its own inflammatory ... Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of ...

*DNAJC1

2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun ... DNAJC1 has been shown to interact with Alpha 1-antichymotrypsin. GRCh38: Ensembl release 89: ENSG00000136770 - Ensembl, May ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of ... 83 (1): 153-67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...

*CMA1

Mellon MB, Frank BT, Fang KC (2002). "Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving ... Caughey GH, Raymond WW, Wolters PJ (2000). "Angiotensin II generation by mast cell alpha- and beta-chymases". Biochim. Biophys ... 1993). "Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus ... 286 (1): 163-73. doi:10.1006/jmbi.1998.2462. PMID 9931257. Pereira PJ, Wang ZM, Rubin H, et al. (1999). "The 2.2 A Crystal ...

*DNA polymerase alpha catalytic subunit

Tsuda M, Masuyama M, Katsunuma T (1986). "Inhibition of human DNA polymerase alpha by alpha 1-antichymotrypsin". Cancer Res. 46 ... DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene. Pol α has limited processivity ... DNA dependent polymerase alpha (Pol α) has been shown to interact with Retinoblastoma protein, PARP1 and RBMS1. DNA Polymerase ... Wong SW, Wahl AF, Yuan PM, Arai N, Pearson BE, Arai K, Korn D, Hunkapiller MW, Wang TS (1988). "Human DNA polymerase alpha gene ...

*MST1

Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro- ... 1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein". Arch. Biochem. Biophys ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Yoshikawa W, Hara H, Takehara T, et al. ( ...

*Protein C inhibitor

The genetic code of protein C inhibitor is similar to alpha 1-antitrypsin and alpha 1-antichymotrypsin. The in vivo half time ... Hayashi S, Wakizaka A (July 1995). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen". Blood ... Billingsley GD, Walter MA, Hammond GL, Cox DW (February 1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, ... alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome ...

*Prostate-specific antigen

PSA exists in serum in the free (unbound) form and in a complex with alpha 1-antichymotrypsin; research has been conducted to ... ISBN 1-891276-02-6. [dead link] Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, deKernion JB, Ratliff ... 154 (2 Pt 1): 407-13. doi:10.1016/S0022-5347(01)67064-2. PMID 7541857. Crawford ED, Schutz MJ, Clejan S, Drago J, Resnick MI, ... 148 (1): 83-6. PMID 1377290. Collins GN, Martin PJ, Wynn-Davies A, Brooman PJ, O'Reilly PH (May 1997). "The effect of digital ...

*Chymotrypsin-C

1996). "Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced ... Brecher AS, Yang MP (1998). "Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity". J. Investig. Med. 46 (4 ... 195 (1-2): 27-39. doi:10.1016/0009-8981(90)90191-T. PMID 2093478. Masson E, Chen JM, Scotet V, et al. (2008). "Association of ... 123 (1): 83-91. doi:10.1007/s00439-007-0459-3. PMID 18172691. Rosendahl J, Witt H, Szmola R, et al. (2008). "Chymotrypsin C ( ...

*Platelet-activating factor

"Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1- ... antichymotrypsin and is stimulated by proteinases". The Journal of Experimental Medicine. 168 (4): 1293-306. doi:10.1084/jem. ... If the sn-1 was removed then PAF lacked any sort of biological activity. Finally, the sn-3 position of PAF was experimented ... 10 (1): 1-6. doi:10.1385/ENDO:10:1:1. PMID 10403564. Yaras N, Ugur M, Ozdemir S, Gurdal H, Purali N, Lacampagne A, Vassort G, ...

*List of MeSH codes (D12.776)

... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ... Retinoid X receptor alpha MeSH D12.776.826.701.500.625 - Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X ... interferon-alpha MeSH D12.776.467.750.500.250.100 - interferon alfa-2a MeSH D12.776.467.750.500.250.150 - interferon alfa-2b ...

*List of MeSH codes (D12.776.124)

... alpha-macroglobulins MeSH D12.776.124.790.720.100.500 -- pregnancy-associated alpha 2-macroglobulins. ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 -- immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.705.500.360 -- immunoglobulin delta-chains MeSH D12.776.124.486.485.705. ... alpha-macroglobulins MeSH D12.776.124.790.106.118 -- antiplasmin MeSH D12.776.124.790.106.125 -- antithrombin iii MeSH D12.776. ...

*Antithrombin

Turk B, Brieditis I, Bock SC, Olson ST, Björk I (1997). "The oligosaccharide side chain on Asn-135 of alpha-antithrombin, ... alpha 1-antichymotrypsin and MENT. The conformational change most relevant for Factor IXa and Xa inhibition involves the P14 ... alpha 2-antiplasmin and Heparin cofactor II. The physiological target proteases of antithrombin are those of the contact ... 7 (1): 27-35. doi:10.1111/j.1365-2362.1977.tb01566.x. PMID 65284. Conard J, Brosstad F, Lie Larsen M, Samama M, Abildgaard U ( ...

*Protease

It includes alpha 1-antitrypsin (which protects the body from excessive effects its own inflammatory proteases), alpha 1- ... antichymotrypsin (which does likewise), C1-inhibitor (which protects the body from excessive protease-triggered activation of ... 568: 1-5. Woessner, edited by Alan J. Barrett, Neil D. Rawlings, J. Fred (2004). Handbook of proteolytic enzymes (2nd ed.). ... 151 (1): 13-25. doi:10.1093/jb/mvr129. PMID 22016395. N D Rawlings and A J Barrett (1993). "Evolutionary families of peptidases ...

*Outline of immunology

Obligate heterodimers of one alpha and one beta subunits Alpha subunits A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 A11 AD AE AL (CD11a) AM ... Alpha-v beta-3 Alpha-v beta-5 Immunoglobulin superfamily CAMs SynCAMs - Synaptic cell adhesion molecules NCAMs - Neural cell ... Fc-alpha receptors (FcαR) FcαRI (CD89, FCAR) Fcα/μR Fc-epsilon receptors (FcεR) FcεRI - Tetramer: FCER1A / FCER1B / two FCER1G ... Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3 Ferritin Fibrin ...

*KLK6

Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (Oct 2003). "Alpha-synuclein degradation by serine ... antichymotrypsin". Clinical Chemistry. 49 (5): 746-51. doi:10.1373/49.5.746. PMID 12709365. Magklara A, Mellati AA, Wasney GA, ... "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)- ... 1350 (1): 11-4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis ...

*Alpha globulin

The alpha globulins typically have molecular weights of around 93 kDa. α1-antitrypsin Alpha 1-antichymotrypsin Orosomucoid ( ... Haptoglobin Alpha-2u globulin α2-macroglobulin Ceruloplasmin Thyroxine-binding globulin Alpha 2-antiplasmin Protein C Alpha 2- ... Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions ... lipoprotein Angiotensinogen Alpha-Globulins at the US National Library of Medicine Medical Subject Headings (MeSH). ...

*Serpin

alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder". The New England Journal of Medicine. 309 (12 ... The X-ray crystal structures of antithrombin, heparin cofactor II, MENT and murine antichymotrypsin reveal that these serpins ... Lomas DA, Evans DL, Finch JT, Carrell RW (June 1992). "The mechanism of Z alpha 1-antitrypsin accumulation in the liver". ... Initial research focused on their role in human disease: alpha 1-antitrypsin deficiency is one of the most common genetic ...

*Serum protein electrophoresis

... resulting in a typical elevation in the alpha-2 zone during inflammation. A normal alpha-2 and an elevated alpha-1 zone is a ... Alpha-2 macroglobulin may be elevated in children and the elderly. This is seen as a sharp front to the alpha-2 band. AMG is ... Stevenson, FT; Greene, S; Kaysen, GA (January 1998). "Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are ... Alpha-1 antitrypsin has an SG group and thiol compounds may be bound to the protein altering their mobility. A decreased band ...
TY - JOUR. T1 - Serum alpha-2-macroglobulin, antitrypsin and antichymotrypsin activities in patients receiving treatment with cyclosporine. AU - Roche, Maya. AU - Kusumanjali, G.. AU - Chinnapu Reddy, G.. AU - Kanagasabhapathy, A. S.. AU - Rao, Pragna. PY - 2006. Y1 - 2006. N2 - Cyclosporine has been reported to function as an inhibitor of the chymotrypsin like activity of proteasome. We hypothesized that the administration of an exogenous proteinase inhibitor may affect the activities of the naturally occurring serum anti proteinases. The aim of this study was to observe the pattern of alteration of serum alpha 2 macroglobulin (AMG), alpha 1- antitrypsin (AT) and alpha 1-antichymotrypsin (ACT) activities in renal transplant patients receiving the immunosuppressive drug, cyclosporine. Patients (97) who had received a single renal allograft were inducted into the study. Subjects were on a twice-daily dosage of cyclosporine capsules. Trough (Co) and two-hour post dose (C 2) cyclosporine levels ...
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Starting with 1130 plasma proteins, we previously derived and then externally validated a 9 protein model (CVD9 [angiopoietin 2, complement C7, α-2 antiplasmin, matrix metalloproteinase 12, α-1 antichymotrypsin complex, growth differentiation factors 11/8, chemokine (C-C motif) ligand 18, angiopoietin related protein 4 and troponin I]) to predict 4-year probability of death, myocardial infarction, stroke and heart failure using SOMAscan proteomic technology in subjects with stable coronary heart disease (CHD). In the current study, we tested whether this proteomic risk score increases within individuals as they approach an event. We applied CVD9 to paired plasma samples from 513 subjects in the Heart and Soul study who were still event free when a second blood sample was taken 4.8 years after the first. There were 139 subjects who had events a median of 2.9 years after their second sample, compared to 374 subjects who did not have events after their second sample (with a median of 4.3 years of ...
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Complete information for SERPINA3 gene (Protein Coding), Serpin Family A Member 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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article{759471dc-3e34-430f-828f-dabeac16accf, abstract = {Prostate-specific antigen (PSA) is a kallikrein-like serine protease mainly expressed in the human prostate. It is responsible for the proteolysis of the gel-forming proteins in human semen. Two major extracellular protease inhibitors, alpha-1-antichymotrypsin (ACT) and alpha-2-macroglobulin (AMG) may inactivate PSA escaping from the prostate. The predominant immunodetected form of PSA in serum is complexed to ACT but PSA exists also in a free non-complexed form despite the large excess of inhibitors. The concentrations of PSA in serum are normally less than 4 micrograms/l. but elevated concentrations are found in a majority of patients with prostate cancer (CAP) and the analysis of PSA in serum has become invaluable in the detection and monitoring of patients with CAP. However, it is not an ideal tumor marker in the sense that there are CAP patients with normal PSA concentrations in serum and patients with benign hyperplasia of the ...
Inflammatory mechanisms contribute to neurodegeneration in AD. Acute phase proteins such as the antichymotrypsin (a1ACT), pro-inflammatory cytokines IL-6 and IL-1, and activated microglial cells are all associated with neuritic plaques. a1ACT levels are elevated in AD, correlate with cognitive decline and serve as a biological marker of intervention. a1ACT is intimately associated with the 42-AA b peptide (Ab) in filamentous amyloid deposits and stimulates the polymerization of Ab into amyloid filaments. IL-6 is found in AD cortices prior to the onset of neuritic change, serum and stimulated PMNC IL-6 levels are higher in AD, and may induce b-amyloid protein deposition. Microglia, CNS resident inflammatory cells, produce IL-6 within the adult human brain, are IL-1a +, and are a prominent component of the neuritic plaque. Because the pathogenesis of AD appears in part immune mediated, we propose testing directly in humans whether ingested IFN-a can ameliorate AD. Because there is no good model ...
Macroscopically, the tumor was of yellow-greyish color and medium consistency. Histologic examination of both the primary and recurrent tumors showed solid nests of tumor cells surrounded by a small rim of connective tissue. The neoplasm consisted of polygonal cells with abundant, eosinophilic, granular cytoplasm and relatively sharp cellular margins. Cytoplasmic granules were distinctly PAS-positive and resistant to diastase digestion. There was remarkable cellular and nuclear polymorphism with hyperchromatic nuclei and prominent nucleoli (Fig. 2).There were small areas of foamy cells and perivascular lymphocytic aggregates. Mitoses were rarely registered. The tumor was moderately vascularized. Frank necrosis was not evident. Immunohistochemically, tumor cells were strongly positive for neuron-specific enolase, S-100 protein, a1-antitrypsin and a1-antichymotrypsin (Fig. 3), but negative for glial fibrillary acidic protein, vimentin, various cytokeratins, melanoma marker HMB 45, chromogranin A, ...
article{9714ffdf-1e21-475d-ac0b-daebdc2182ca, abstract = {Clearance of the amyloid-P peptide (A beta) as a remedy for Alzheimers disease (AD) is a major target in on-going clinical trials. In vitro studies confirmed that A beta is taken up by rodent astrocytes, but knowledge on human astrocyte-mediated A beta clearance is sparse. Therefore, by means of flow cytometry and confocal laser scanning microscopy (CLSM), we evaluated the binding and internalization of A beta 1-42 by primary human fetal astrocytes and adult astrocytes, isolated from nondemented subjects (n = 8) and AD subjects (n = 6). Furthermore, we analyzed whether alpha 1-antichymotrypsin (ACT), which is found in amyloid plaques and can influence A beta fibrillogenesis, affects the A beta uptake by human astrocytes. Upon over night exposure of astrocytes to FAM-labeled A beta 1-42 (10 mu M) preparations, (80.7 +/- 17.7)% fetal and (52.9 +/- 20.9)% adult A beta-positive astrocytes (P = 0.018) were observed. No significant difference ...
A A beta 42 abl acid phosphatase ACSM1 actin-general actin-alpha cardiac actin-alpha smooth muscle actin-muscle specific AE1/AE3 (cytokeratin) AF4 AGR2 AKT1 albumin alcian blue ALK alkaline phosphatase ALL1 alpha-1-antichymotrypsin alpha-1-antitrypsin alpha-fetoprotein alpha-lactalbumin AMACR AML1 androgen receptor APC API2-MALT1 Apolipoprotein D arginase1 ATM ...
The free/total PSA ratio (%fPSA) is an additional new parameter used in assessing PSA levels. Some authors 1,2 recommend that men with PSA levels of 4.1 to 10 ng/mL who are not suspected of having prostate cancer by whatever means should undergo ...
Yashraj Biotechnology is an ISO 13485:2003 certified company. Since 1999, we are engaged in manufacturing of Native & Recombinant antigens. We serve our high quality purified antigens to the worldwide, leading diagnostic companies. We currently manufacture CRP • HBsAg-Ay & Ad • CA 15-3 • CA-125 • CA 72-4 • CA 19-9 • B2M • PSA & PSA-ACT • CEA • AFP • A1M • B2M •CYS-C • PR3 • MPO • D-Dimer • NGAL • PAPP-A • sTfR • Ferritin •KFLC • LFLC • RBP. HE-4 , rec-SLO. Mabs- PSA • CRP • CA 125-3 • HbA1c. ...
The authors acknowledge the following members of the Okayama Urological Cancer Collaborating Group; Toyoko Yamato, M.D., Ph.D. (Okayama City Hospital); Michinao Saegusa, M.D., Ph.D. (Hiroshima Citizens Hospital); Toshihiko Asahi, M.D., Ph.D. (Kagawa Prefectural Central Hospital); Bunzo Suyama, M.D., (Mitoyo General Hospital); Tadashi Oeda, M.D., Ph.D. (Onomichi Municipal Hospital); Takanori Murakami, M.D. (National Okayama Hospital); Yoshio Maki, M.D., Ph.D. (Konko Hospital); Teruaki Akaeda, M.D., Ph.D. (Tsuyama Central Hospital); Masatoshi Noda, M.D., Ph.D. (Saint Maria Hospital); Teruhisa Ohashi, M.D., Ph.D. (Okayama Redcross Hospital); and Masahiro Hara, M.D., Ph.D. (Fukuyama Municipal Hospital). ...
Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O. A complex between prostate-specific antigen and α1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991; 51: 222-6 ...
The superfamily of ser ine p roteinase in hibitors (serpins) is involved in numerous fundamental biological processes as inflammation, blood coagulation and apoptosis. Our interest is focused on the SERPINA3 sub-family. The major human plasma protease inhibitor, α1-antichymotrypsin, encoded by the SERPINA3 gene, is homologous to genes organized in clusters in several mammalian species. However, although there is a similar genic organization with a high degree of sequence conservation, the reactive-centre-loop domains, which are responsible for the protease specificity, show significant divergences. We provide additional information by analyzing the situation of SERPINA3 in the bovine genome. A cluster of eight genes and one pseudogene sharing a high degree of identity and the same structural organization was characterized. Bovine SERPINA3 genes were localized by radiation hybrid mapping on 21q24 and only spanned over 235 Kilobases. For all these genes, we propose a new nomenclature from SERPINA3-1 to
In this study, we focused on four glial proteins that are abundant in amyloid plaques and/or that are known to interact with Abeta: alpha1-antichymotrypsin (ACT), interleukin-1beta (IL-1beta), S100beta, and butyrylcholinesterase (BChE). We examined the ability of these proteins to activate rat cortical astrocyte cultures and to influence the ability of Abeta to activate astrocytes. Treatment of astrocytes with ACT, IL-1beta, or S100beta resulted in glial activation, as assessed by reactive morphology, upregulation of IL-1beta, and production of inducible nitric oxide synthase and nitric oxide. The ability of Abeta to induce astrocyte activation was also enhanced in the presence of each of these three proteins. In contrast, BChE alone did not activate astrocytes and had no effect on Abeta-induced activation ...
14.3.3 Pan, Acinus, AIF (Apoptosis Inducing Factor), Alpha-1-antichymotrypsin, alpha-1-antitrypsin, ARC, Ask1/MAPKKK5, ATM, BAG-1, Bak, Bax, Bcl10/CIPER/CLAP/mE10, bcl-2a, Bcl-6, bcl-X, bcl-XL, Bim (BOD), Caspase 1, Caspase 2, Caspase 3, Caspase 5, Caspase 6 (Mch 2), Caspase 7 (Mch 3), Caspase 8 (FLICE), Cathepsin D, CD137 (4-1BB), CD14, CD95/Fas, CDK2, CDK4, CDK5, c-fos, CIDE-A, CIDE-B, c-jun, CREB, CREB-Binding Protein, Cytochrome c, D4-GDI, Daxx, DcR1, DcR2/TRAIL-R4/TRUNDD, DFF40 (DNA Fragmentation Factor 40)/CAD, DFF45/ICAD, DR3, DR5, ERK1, ERK2, FADD (FAS-Associated death domain-containing protein), Fas-ligand, FLIP, Granzyme B, Heat Shock Protein 70/hsp70, I-FLICE/CASPER, IGF-1R, IGF-I, I-Kappa-B Kinase b (IKKb), JNK Activating kinase (JKK1), MADD, Mcl-1, Mekk-1, NF kappa B/p50, NF kappa B/p65 (Rel A), p53, PARP, PARP (Poly ADP-Ribose Polymerase), Prohibitin, RAIDD, SODD (Silencer of Death Domain), Survivin, TNF alpha, TNFa, ...
Armstrong RA, Winsper SJ, Blair JA (1995) Hypothesis: is Alzheimers disease a metal_induced immune disorder? Neurodegeneration 4:107_111 Bennett SA, Stevenson B, Staines WA, Roberts DC (1995) Periodic acid_Schiff (PAS)_positive deposits in brain following kainic acid_induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood_brain barrier breakdown. Acta Neuropathol Berl 89:126_138 Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross_linking in Alzheimer disease. Acta Neuropathol Berl 89:291_295 Das S, Potter H (1995) Expression of the Alzheimer amyloid_promoting factor antichymotrypsin is induced in human astrocytes by IL_1. Neuron 14:447_456 De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute ...
Urticaria cholinergic is another type of the Urticaria that is caused by a certain physical stimulus of some or of the other class. It is classified like physical urticaria, meaning that is caused by a physical stimulus of a certain class. The physical stimulus could be indicated as heat although the real cause is defined as sweating. The study of the activity of the cell of the mast includes Urticaria generally cholinergic because most of the cases of Urticaria cholinergic looks like to critically imply the cells of the mast. The main mediator is the histamina of the serum, that rises in the concentration when an induced test exercise is introduced. This treatment also implies quimiotácticos factors eosinophil and of the neutrophil as well as it tryptase. The levels of the alpha 1-antichymotrypsin diminish, and the use of danazol gives rise to the improvement in the eruption. Due to these results, some have discussed in please proteases like a cause of the histamina that was sent. The skin ...
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Sulfacetamida La Santé is a medicine available in a number of countries worldwide. A list of US medications equivalent to Sulfacetamida La Santé is available on the Drugs.com website.
Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
Polymorphonuclear neutrophils (PMN) play an important role in myocardial ischemia/reperfusion (MI/R) injury; however, the role of neutrophilic proteases is less understood. The effects of a novel serine protease inhibitor (serpin), LEX032, were investigated in a murine model of MI (20 min) and R (24 hr) injury in vivo. LEX032 is a recombinant human alpha 1-antichymotrypsin in which six amino acid residues were replaced around the active center with those of alpha-1 protease inhibitor. LEX032 has the ability to inhibit both neutrophil elastase and cathepsin G, two major neutral serine proteases in neutrophils, as well as superoxide generation. LEX032 (25 or 50 mg/kg) administered i.v. 1 min before reperfusion significantly attenuated myocardial necrotic injury evaluated by cardiac creatine kinase loss compared to MI/R rats receiving only vehicle (P , .001). Moreover, cardiac myeloperoxidase activity, an index of PMN accumulation, in the ischemic myocardium was significantly attenuated by LEX032 ...
... ,, PSA exists in multiple forms in the blood. Most is bound to proteins, but some is free-floating. In the early 1990s, it was discovered that measuring the ratio of free to total PSA could furth,medicine,medical supply,medical supplies,medical product
Prostate cancer free psa - PSA: At a Glance | Prostate Specific Antigen. Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function.
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Objectives. Improved discrimination between prostate cancer (PC) and benign prostatic hyperplasia (BPH) is clearly needed. Our aim in this study was to evaluate whether the free to total prostate-specific antigen (PSA) ratio would be useful in the gray zone of 1.8-10 ng/mL total PSA range. Methods. In a consecutive series of 435 clinic patients referred for prostate evaluation, 308 had a total PSA ,10 ng/mL (92 had PC and 216 BPH). Free and total PSA were measured, and the free to total PSA ratio calculated. Results. Total PSA values were significantly different between the two groups. For the 200 patients with a total PSA ,6 ng/mL, no significant difference in total PSA values were seen (P = 0.411), whereas free to total PSA ratios remained statistically different (P , 0.001). Receiver operating characteristic (ROC) curve analysis comparing the performances of total PSA over the ratio of free to total PSA showed a clear advantage for the ratio at all sensitivity levels. Conclusions. These data ...
Several PSA isoforms have been identified that can further increase the specificity of PSA for prostate cancer. In particular, the [-2] form of proPSA (p2PSA) shows improved performance over either total or free PSA for prostate cancer detection on biopsy. The prostate health index (phi) is a formula that combines all 3 PSA forms (total PSA, free PSA, and p2PSA) into a single score. Phi is calculated using the following formula: (p2PSA/free PSA) x square root (PSA).. In a multicenter study that compared the performance of PSA, free PSA, p2PSA, and phi in men undergoing prostate biopsy due to a serum PSA concentration between 4 and 10 ng/mL, phi was the best predictor of any prostate cancer, high-grade cancer, and clinically significant cancer. At 95% clinical sensitivity, the clinical specificity of phi was 16.0%, compared to 8.4% for free PSA and 6.5% for PSA.. Prostatic biopsy is required for diagnosis of cancer.. ...
Aim: To examine the potential clinical implications of the recalibration of total prostate-specific antigen (PSA) and free PSA (fPSA) assays to the World Health Organization (WHO) standard materials. Material and methods: Data from 1098 patients with or without clinically detected prostate cancer (PCa) from four independent cohort studies were compared using commercial assays calibrated to the traditional Hybritech® PSA (PSA-Hyb) and fPSA (fPSA-Hyb) standards and to the WHO 96/670 (PSA-WHO) and 96/668 (fPSA-WHO) standards. The Access® Immunoassay System (Beckman Coulter, Inc.) was used in all studies. Results: All studies showed 20% to 25% lower PSA and fPSA test results with the WHO-standardized assays. No significant change in %fPSA (fPSA/ PSA × 100) was observed. Continuing to use the traditional clinical PSA cutoffs obtained with the Hybritech standard after changing to the PSA-WHO standard could result in up to one-third of prostate cancer cases being missed. Conclusions: Manufacturers ...
How is it used?. If prostate cancer is diagnosed, the total PSA test may be used as a monitoring tool to help determine the effectiveness of treatment. It may also be ordered at regular intervals after treatment to detect recurrence of the cancer.. The total PSA test and digital rectal exam (DRE) may be used to screen both asymptomatic and symptomatic men for prostate cancer. If either the PSA or the DRE are found to be abnormal, then the doctor may choose to follow this testing with a prostate biopsy and perhaps imaging tests, such as an ultrasound. If the DRE is normal but the PSA is moderately elevated, the doctor may order a free PSA test to look at the ratio of free to total PSA. This can help to distinguish between prostate cancer and other non-cancer causes of elevated PSA. Since the total PSA test can be elevated temporarily for a variety of reasons, a doctor may order another PSA a few weeks after the first to determine if the PSA is still elevated.. Currently there is no consensus ...
The incidence of prostate cancer has increased substantially in many countries over the last few decades. Fifteen to 20 years ago, the probability that a man would be diagnosed with prostate cancer was 4% to 6% in most industrialised countries but, currently, 17% of men in the US and 5% to 10% in Europe are expected to be diagnosed with this disease during their lifetime. At the same time, mortality has remained fairly constant ranging from 2% to 3.5% in various countries.1,2 Thus, prostate cancer is a serious health problem.
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Looking for serine proteinase inhibitor? Find out information about serine proteinase inhibitor. A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process. Explanation of serine proteinase inhibitor
faced a yeomans task: Proving its validity and creating assays to ensure its accuracy. In 1987, Stanford Universitys Thomas Stamey demonstrated that the PSA test-though more sensitive than the prostatic acid phosphotase test-was not very specific, given that levels of PSA may be elevated due to reasons other than cancer (such as age, benign prostatic hyperplasia or prostatitis). True, the test detects early tumors, but at the time, it was also fraught with so many false alarms that many urologists began working to refine the test. For instance, Scandinavian researchers Hans Lilja and Ulf-Hakan Stenman suggested in 1991 that "free PSA"-unattached antigen floating in the bloodstream-is lower in men with cancer. In 1998, Catalona confirmed that reading both free PSA and total PSA was a better way to determine whether biopsy was needed in a patient with elevated antigen levels. In 1992, H. Ballentine Carter of Johns Hopkins demonstrated that the rate of rise in PSA levels was greater in men with ...
Use of percent free PSA in the detection of prostate cancer. Sadovsky, Richard // American Family Physician;10/1/1997, Vol. 56 Issue 5, p1450 Focuses on the study on the use of prostate-specific antigen (PSA) in the detection of prostate cancer, which appeared in the 1997 issue of `Mayo Clinic Proceedings, by A.R. Vashi and J.E. Oesterling. Discovery of prostate-specific antigen (PSA); Effects of organ-specific nature of PSA;... ...
感染 創傷 炎症等應激原作用於動物機體,造成機體穩態失衡,引起一系列反應,如發熱 負氮平衡 白細胞增多 促腎上腺皮質激素(ACTH)和糖皮質激素分泌增多 補體系統和凝集系統激活 血清微量元素濃度改變及一些血漿蛋白濃度的改變等,稱為急性期反應》在應激刺激下所產生變化的蛋白即為急性期蛋白(acutephaseprotein, APP),又叫急性期反應物或應激敏感蛋白質主要由肝臟合成,多為含糖的球蛋白》 ...
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Looking for online definition of serine proteinase inhibitor in the Medical Dictionary? serine proteinase inhibitor explanation free. What is serine proteinase inhibitor? Meaning of serine proteinase inhibitor medical term. What does serine proteinase inhibitor mean?
UNLABELLED: The introduction of total prostate specific antigen (total PSA) testing in blood has revolutionized the detection and management of men with prostate cancer (PCa). The objective of this review was to discuss the challenges of PCa biomarker research, definition of the type of PCa biomarkers, the statistical considerations for biomarker discovery and validation, and to review the literature regarding total PSA velocity and novel blood-based biomarkers. METHODS: An English-language literature review of the Medline database (1990 to August 2010) of published data on blood-based biomarkers and PCa was undertaken. RESULTS: The inherent biological variability of total PSA levels affects the interpretation of any single result. Men who will eventually develop PCa have increased total PSA levels years or decades before the cancer is diagnosed. Total PSA velocity improves predictiveness of total PSA only marginally, limiting its value for PCa screening and prognostication. The combination of PSA
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Alpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage caused by activated enzymes. Alpha-1 antitrypsin tests help diagnose alpha-1 antitrypsin deficiency.
Alpha-1 antitrypsin (AAT) is a protein that protects the lungs from damage caused by activated enzymes. Alpha-1 antitrypsin tests help diagnose alpha-1 antitrypsin deficiency.
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The Texas A&M Health Science Center provides the state with health education, outreach and research through campuses in Bryan-College Station, Dallas, Temple, Houston, Round Rock, Kingsville, Corpus Christi and McAllen. Its six colleges are the Baylor College of Dentistry, College of Medicine, College of Nursing, School of Graduate Studies, Irma Lerma Rangel College of Pharmacy and School of Rural Public Health. Other units include the Institute of Biosciences and Technology and Coastal Bend Health Education Center. ...
Various blood constituents can interfere with immunoassays, usually by binding the Fc portion of antibodies. Our previously developed assays for intact free prostate-specific antigen (PSA), free human kallikrein 2 (hK2), and total hK2 frequently yielded falsely high results despite including an excess of scavenger antibodies. We investigated whether this interference could be eliminated by replacing monoclonal capture or tracer antibodies with F(ab)2 or recombinant Fab fragments. Female heparin plasma samples (n = 1092), which should have negligible PSA and hK2, and male samples (n = 957) were analyzed to identify samples manifesting interference, which then were used to optimize protocols for the immunoassays. We compared original assays (monoclonal antibodies) versus optimized assays (F(ab)2 fragments: denatured mouse IgG added as scavenger) using another set of EDTA plasma (n = 113), heparin plasma (n = 160), and serum samples (n = 171). With the original assays, the frequency of falsely elevated
Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute phase proteins) or decrease (negative acute phase proteins) in response to inflammation. This response is called the acute-phase reaction (also called acute phase response). In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL-1, IL-6 and IL-8, and TNF-α. The liver responds by producing a large number of acute-phase reactants. ...
Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum) to determine the prostate-specific-antigen (PSA) enzyme, either total or free (fPSA); these reagents include antibodies (typically monoclonal antibodies) with the capability of binding to this tumor marker. PSA level is used to monitor treatment of prostate carcinoma because it correlates with the stages of tumor extension and metastasis; the level of total and/or free PSA and the proportion of free to total PSA are also used in diagnosis of prostate carcinoma and its differentiation from benign prostatic hyperplasia.. Related Terms : "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Prostate Cancer". Entry Terms : "PSA (Prostatic Specific Antigen) Determination Reagents" , "Prostatic Specific Antigen (PSA) Determination Reagents" , "Free Prostatic Specific Antigen (fPSA) Determination Reagents" , "Reagents, Prostate-Specific Antigen (PSA)" , "Prostate-Specific ...
Objectives To investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men. Methods 129 male participants, ranging in age from 50 to 71 years (mean 55 years), rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled. Results Bicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1-12.9; p|0.001) or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml) increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges). Univariate linear regression analysis
Theres a gas line that runs past but its the commitment out of that gas line thats a critical factor." AACT says it will know shortly if Griffith is the best site for the $7.5m project. The company is also considering plants at Parkes, Forbes, Condobolin or West Wyalong. Mr Young says the company has received enough grower interest to cover half of its target area of 8000 hectares. Mr Young says the chosen site must have natural gas, water and power, road and rail access and grower interest. "That should be done by the 15th, 16th of March," he said. "The first step for us will be to put in storage facilities to take the commodity, and the processing plant itself will be hopeful up and running by December 2014.. "But we have a contingency plan thatll allow us to push through to March in case things dont go our way." ...
Alpha-1 antitrypsin - MedHelps Alpha-1 antitrypsin Center for Information, Symptoms, Resources, Treatments and Tools for Alpha-1 antitrypsin. Find Alpha-1 antitrypsin information, treatments for Alpha-1 antitrypsin and Alpha-1 antitrypsin symptoms.
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Background: Black men exhibit a high prevalence of vitamin D deficiency as well as higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate specific antigen (PSA) in healthy Black men. Methods: During 3 winters from 2007-2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. At baseline and 3 months, free and total PSA were measured. Results: With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA: -0.0004 ng/mL (p=0.94) and total PSA: -0.004 ng/mL (p=0.92) for each additional 1000 IU/d of vitamin D3. Conclusion: Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA. Impact: These findings support prior ...
AbstractBackgroundClinical trials are typically designed using the classical frequentist framework to constrain type I and II error rates. Sample sizes required in such designs typically range from hundreds to thousands of patients which can be challenging for rare diseases. It has been shown that rare disease trials have smaller sample sizes than non-rare disease trials. Indeed some orphan drugs were approved by the European Medicines Agency based on studies with as few as 12 patients. However, some studies supporting marketing authorisation included several hundred patients. In this work, we explore the relationship between disease prevalence and other factors and the size of interventional phase 2 and 3 rare disease trials conducted in the US and/or EU. We downloaded all clinical trials from Aggregate Analysis of ClinialTrials.gov (AACT) and identified rare disease trials by cross-referencing MeSH terms in AACT with the list from Orphadata. We examined the effects of prevalence and phase of study in
A class of proteins indicative of inflammation response, acute phase proteins are important compliments to antigens and antibodies for the clinical diagnostics industry.
Health, ...DURHAM N.C. -- Men who are overweight or obese have lower concentrati...The finding echoes earlier results on PSA concentrations found in obes...A study released last year from our group showed that obese and overwe...We found that mildly obese mens PSA scores were fourteen percent lower...,Overweight,and,obese,men,have,lower,PSA,values,,even,before,they,get,prostate,cancer,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Learn more about Prostate-Specific Antigen (PSA) Test at Grand Strand Medical Center DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
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Buy SERPINA1 antigen, ALPHA 1 ANTITRYPSIN Antigen-NP_000286.3 (MBS238024) product datasheet at MyBioSource, Antigens. Application: ELISA (EIA)
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Background: The goal of this study was to evaluate the clinical impact of using the same total prostate-specific antigen (tPSA) and free PSA (fPSA) assays calibrated with World Health Organization (WHO) materials or with Hybritech Tandem-R calibrator. Methods: From the initial correlation study that included 150 patients, the clinical impact of the WHO calibration was simulated using a large cohort (n = 4548) of referred patients. Interim reports of the European Study of Screening for Prostate Cancer (ERSPC) were used to evaluate the clinical outcomes of patients and the risk of prostate cancer (PCa). Results: WHO calibration of tPSA assays leads to a reduction of about 20% in measured results (tPSA WHO = 0.81 tPSA Hybritech + 0.04; fPSA WHO = 0.78 fPSA Hybritech + 0.00; %fPSA WHO = 0.92 %fPSA Hybritech + 0.00). The simulation showed that the WHO calibration is associated with a risk of missing 15% of PCa. Conclusions: The discrepancies between the two calibrations lead to significant clinical ...
Men who are overweight or obese have lower concentrations of prostate-specific antigen (PSA) in their blood than their normal-weight counterparts, according to a new study led by Duke University Medical Center researchers. The finding echoes earlier results on PSA concentrations found in obese and overweight men with prostate cancer and highlights thehttp://www.blogger.com/img/gl.link.gif need to reconsider PSA threshold values for heavier patients, and to encourage those patients to get serious about losing weight. The prevalence of obesity in the United States has doubled in the past 15 years," Price said. Our study demonstrates yet another health danger that obesity poses. One in three Americans is obese, and a man who is 511" and weighs 215 pounds is considered obese. The best advice clinicians can give their patients is to adopt healthier lifestyles, said Stephen Freedland, M.D., a urologist at Duke and the studys senior author. We tell patients to exercise three or four times a week, ...
The purpose of this randomized, double-blind, placebo-controlled study is to evaluate the short-term safety of inhaled recombinant alpha 1-antitrypsin (rAAT) in subjects with alpha 1-antitrypsin deficiency. The subjects are randomized to receive placebo or one of 4 doses of rAAT. The 4 doses are tested in a consecutive manner from lowest to highest ...
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Thank you for all the support and encouragement from everyone since diagnosis, intervention, and healing well! My free PSA test for September, Prostate Cancer A...
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What makes your socks antibacterial? Most likely the fabric has been treated with nano sized particles of silver, but what are the nanosilver dangers?

Anti-alpha 1 Antichymotrypsin antibody (ab223226) | AbcamAnti-alpha 1 Antichymotrypsin antibody (ab223226) | Abcam

Goat polyclonal alpha 1 Antichymotrypsin antibody validated for WB and tested in Human. Immunogen corresponding to synthetic ... All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab223226) at 0.3 µg/ml. Lane 1 : Human albumin-depleted serum lysate (in ... Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the ... Anti-alpha 1 Antichymotrypsin antibody. See all alpha 1 Antichymotrypsin primary antibodies. ...
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Avhandlingar.se: ALPHA-1-ANTICHYMOTRYPSINAvhandlingar.se: ALPHA-1-ANTICHYMOTRYPSIN

Avhandlingar om ALPHA-1-ANTICHYMOTRYPSIN. Sök bland 88530 avhandlingar från svenska högskolor och universitet på Avhandlingar. ... alpha-1-antichymotrypsin. . *. 1. Metabolism of free and complexed prostate - specific antigen and their utility for diagnosis ... 3. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders. Detta är en ... Sammanfattning : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver ...
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Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921) ProtocolsAnti-alpha 1 Antichymotrypsin antibody, prediluted (ab921) Protocols

Abcam provides specific protocols for Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921) : Immunohistochemistry ...
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Serpin A3/alpha 1-Antichymotrypsin Proteins: Novus BiologicalsSerpin A3/alpha 1-Antichymotrypsin Proteins: Novus Biologicals

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Serpin A3/alpha 1-Antichymotrypsin Proteins: Novus BiologicalsSerpin A3/alpha 1-Antichymotrypsin Proteins: Novus Biologicals

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Alpha-1-antichymotrypsin / ACT (full length) antibody. Not available. Mouse. IgG1. 1E6. Purified. Hu. E, IP, P, WB. 50 µg / € ... Background of Alpha-1-antichymotrypsin / ACT antibody. SERPI3 is a plasma protease inhibitor and member of the serine protease ... Alternative names for Alpha-1-antichymotrypsin / ACT antibody. SERPINA3, AACT, GIG24, GIG25, Cell growth-inhibiting gene 24/25 ... Recombinant human Alpha-1-antichymotrypsin (24-423 aa), His-tagged: 15% SDS-PAGE (3 µg). *AR09303PU-L ...
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Alpha 1-antichymotrypsin - WikipediaAlpha 1-antichymotrypsin - Wikipedia

Alpha 1-antichymotrypsin (symbol α1AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin ... Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in ... Alpha-1 antitrypsin, another serpin that is analogous for protecting the body from excessive effects of its own inflammatory ... Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimers disease as it enhances the formation of ...
more infohttps://en.wikipedia.org/wiki/Alpha_1-antichymotrypsin

SERPINA3 antigen | Alpha 1 Antichymotrypsin Antigen-NP 001076.2SERPINA3 antigen | Alpha 1 Antichymotrypsin Antigen-NP 001076.2

Alpha 1 Antichymotrypsin Antigen-NP_001076.2 (MBS568719) product datasheet at MyBioSource, Antigens. Application: Immunogen ... Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of ... Hexokinase 1 (HK2) Antibody. • TGM2 (Transglutaminase 2, Tissue) CLIA Kit. • B-Raf Proto Oncogene Serine-Threonine Protein ... both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human ...
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Human alpha 1 antichymotrypsin Recombinant | ReprokineHuman alpha 1 antichymotrypsin Recombinant | Reprokine

Optimized DNA sequence encodingHuman alpha 1 antichymotrypsin -AACT (HIS23 - ALA423) mature chain including a C-terminal His ... Human alpha 1 antichymotrypsin Recombinant. Home/Cytokines/Human reagents/Recombinant Human Cytokines/Human alpha 1 ... Recombinant Human alpha 1 antichymotrypsin (AACT) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to- ... Recombinant human alpha 1 antichymotrypsin(AACT) is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose. ...
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Anti-alpha 1 Antichymotrypsin 抗体 (ab107362)Anti-alpha 1 Antichymotrypsin 抗体 (ab107362)

... alpha 1 Antichymotrypsin抗体一覧…画像、プロトコール、文献などWeb上の情報 ... All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab107362) at 1 µg/ml. Lane 1 : Human spinal cord tissue lysate - total ... Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the ... alpha 1 Antichymotrypsin contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a
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Buy Recombinant Human Alpha-1 AntiChymotrypsin Protein (pro-750)Buy Recombinant Human Alpha-1 AntiChymotrypsin Protein (pro-750)

Buy online Recombinant Human Alpha-1 AntiChymotrypsin Protein from Prospec cat# pro-750. ProteoGenix provides you the best ... More info about Recombinant Human Alpha-1 AntiChymotrypsin Protein. Catalog#: pro-750. ...
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Gentaur Molecular :Kamiya \ Human Alpha 1 Anti Chymotrypsin ELISA \ KT-498Gentaur Molecular :Kamiya \ Human Alpha 1 Anti Chymotrypsin ELISA \ KT-498

Human Alpha 1_Anti_Chymotrypsin ELISA \ KT-498 for more molecular products just contact us ... Anti_Chymotrypsin ELISA. Related products : Human Alpha 1_Anti_Chymotrypsin ELISA ... Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha). [HBB] Hemoglobin subunit beta (Beta-globin) ( ... WP1047: TNF-alpha NF-kB Signaling Pathway. WP1120: Ovarian Infertility Genes. WP1163: TNF-alpha NF-kB Signaling Pathway. WP1209 ...
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Athens Research And Technology | SBIR.govAthens Research And Technology | SBIR.gov

USE OF ANTIBODIES TO MODIFIED ALPHA 1 ANTICHYMOTRYPSIN. Amount: $50,000.00 ALZHEIMERS DISEASE (AD), A LEADING HEALTH PROBLEM ... RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY. Amount: $500,000.00 THIS PROPOSAL INVOLVES THE DEVELOPMENT OF A ... SIMPLE ASSAY FORMEASURING FUNCTIONAL (1)-PROTEINASE INHIBITOR LEVELS IN HUMAN TISSUES. THE PROCEDURE UTILIZES THE FACT THAT ...
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ELISA Kits (A-Z) - ELISA Kits - ProductsELISA Kits (A-Z) - ELISA Kits - Products

Alpha-1 Acid Glycoprotein 1 (Human) ELISA Kit. Catalog #: E4783 , Datasheet $740.00 ...
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Category:Acute phase proteins - Wikimedia CommonsCategory:Acute phase proteins - Wikimedia Commons

Proteínas de fase aguda (es); Beljakovina akutne faze (sl); Protéine de phase aiguë (fr); protein akutní fáze (cs); Akutfasprotein (sv); Białka ostrej fazy (pl); پروتئین فاز حاد (fa); acutefase-eiwit (nl); Akūtas fāzes olbaltumi (lv); Proteina di fase acuta (it); Akute-Phase-Protein (de); Proteínas de fase aguda (pt); Acute-phase protein (en); بروتين طور حاد (ar); 急性期蛋白 (zh); Akutfaseprotein (da) Proteinas de fase aguda (es); Réaction de phase aiguë, Proteine de phase aigue (fr); Akute-Phase-Proteine, Akut-Phase-Protein (de); Akutfasproteiner (sv); protein akutního stavu, proteiny akutní fáze, reaktant akutní fáze, reaktanty akutní fáze (cs); 急相蛋白 (zh); acuut fase eiwit, acute-fase eiwit (nl ...
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Larynx and hypopharynx - Squamous cell carcinoma - generalLarynx and hypopharynx - Squamous cell carcinoma - general

Alpha-1-antichymotrypsin. Vimentin. CD68. Cytokeratin AE1/AE3. Positive stains. ...
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8b GUG Quiz - By jenjen0018b GUG Quiz - By jenjen001

alpha receptors in peripheral vasculature. MC site of mets in metastatic breast cancer. skull w/o involving brain, also lung ... Marker WT-1. bilateral (like lobular carcinoma sez Goljan). malignant germ cell tumor: beta HCG. young pt, before puberty, poor ... 1 killer of neonates. preterm labor 20 to 36+6 weeks, esp mult gestations. ... Rate 5 stars Rate 4 stars Rate 3 stars Rate 2 stars Rate 1 star ... free or bound to alpha 1-antichymotrypsin. MCC of amenorrhea ( ...
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March 2015 - Volume 34 - Issue 3 : The Pediatric Infectious Disease JournalMarch 2015 - Volume 34 - Issue 3 : The Pediatric Infectious Disease Journal

Proteome Demonstration of Alpha-1-Acid Glycoprotein and Alpha-1-Antichymotrypsin Candidate Biomarkers for Diagnosis of ... Rapid Viral Rebound After 4 Years of Suppressive Therapy in a Seronegative HIV-1 Infected Infant Treated From Birth. Butler, ... Deficiency of Interleukin-1 Receptor-associated Kinase 4 Presenting as Fatal Pseudomonas aeruginosa Bacteremia in Two Siblings ...
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SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasionSERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion

Kalsheker NA: Alpha 1-antichymotrypsin. Int J Biochem Cell Biol. 28:961-964. 1996. View Article : Google Scholar : PubMed/NCBI ... Sun YX, Wright HT and Janciauskiene S: Glioma cell activation by Alzheimers peptide Abeta1-42, alpha1-antichymotrypsin, and ... Karashima S, Kataoka H, Itoh H, Maruyama R and Koono M: Prognostic significance of alpha-1-antitrypsin in early stage of ... Tahara E, Ito H, Taniyama K, Yokozaki H and Hata J: Alpha 1-antitrypsin, alpha 1-antichymotrypsin, and alpha 2-macroglobulin in ...
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Liver : Quiz (The Full Wiki)Liver : Quiz (The Full Wiki)

Alpha 1-antichymotrypsin. Tumor necrosis factor-alpha. B-cell activating factor. Thrombopoietin. ... Question 1: The liver is a vital organ present in ________ and some other animals.. Tunicate. Chordate. Arthropod. Vertebrate. ...
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nature.com searchnature.com search

Rights & permissionsfor article DEFICIENCY OF ALPHA-1-ANTICHYMOTRYPSIN IN ASTHMATIC CHILDREN . Opens in a new window. ... 1 October 1985 THEOPHYLLINE CONCENTRATION MEASUREMENTS IN SERUM OR SALIVA FOR THERAPY MONITORING IN BRONCHIAL ASTHMA *W Leupold ... 1 June 1983 Airway Resistance, Airway Conductance, Specific Airway Resistance, and Specific Airway Conductance in Children *M ... 1 September 1989 PERCUTANEOUS ENDOSCOPIC CONTROLLED GASTROSTOMY (PEG) FOR ALIMENTATION OF CHILDREN WITH CYSTIC FIBROSIS *B ...
more infohttp://www.nature.com/search?author=%22H%20Von%20Der%20Hardt%22&error=cookies_not_supported&code=fcb7c46c-01cc-46f0-89c3-31100b2ccd2b

Oral cavity - Acinic cell carcinomaOral cavity - Acinic cell carcinoma

Alpha 1-antitrypsin, alpha 1-antichymotrypsin *IgA, CEA, LeuM1 *amylase, cyclooxygenase-2, vasoactive intestinal polypeptide * ... M/F = 1:2 to 1:3 *Fairly even distribution of patients from second to fifth and sixth decades of life (J Oral Maxillofac Surg ... Tumor size: 1-3 cm, occassionally > 10 cm *Usually circumscribed, but some are ill-defined with irregular peripheries *Lobular ... Distribution of primary sites (n=11): buccal mucosa (4), maxilla/maxillary sinus (2), hard palate (1), junction of hard and ...
more infohttp://www.pathologyoutlines.com/topic/oralcavityacinic.html

Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |...Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study |...

... while alpha-2-macroglobulin and ceruloplasmin were lower (p < 0.05). C3adesArg and ITIH4 have previously been related to the ... apolipoprotein E and isoform 1 of inter-alpha trypsin inhibitor heavy chain H4 (ITIH4) were found to be higher in pre- ... In the 1980s however, the acute phase proteins alpha-2-macroglobulin and ceruloplasmin were already studied in relation to ... To our knowledge, afamin, apolipoprotein E, alpha-2-macroglobulin and ceruloplasmin have not been found before to differ ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-381

Native Proteins |  Cell SciencesNative Proteins | Cell Sciences

Native Human alpha 1-Antichymotrypsin/Serpin A3. 100 μg. $250.00 BUY CSI19774A. Native Human Alpha-1-Antichymotrypsin 0.5 mg. $ ... Native Human alpha 1-Antichymotrypsin/Serpin A3. 1.0 mg. $725.00 BUY CSI19612A. ...
more infohttp://www.cellsciences.com/proteins/native?alphabet_bar_name=2036&p2=
  • Use a concentration of 0.3 - 1 µg/ml. (abcam.com)
  • Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. (wikipedia.org)
  • GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. (wikipathways.org)