alpha 1-Antichymotrypsin: Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.alpha 1-Antitrypsin: Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.Serine Proteinase Inhibitors: Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.Fluoroimmunoassay: The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.Pancreatin: A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.Immunoelectrophoresis, Two-Dimensional: Immunoelectrophoresis in which a second electrophoretic transport is performed on the initially separated antigen fragments into an antibody-containing medium in a direction perpendicular to the first electrophoresis.Cathepsins: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.Acute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.OrosomucoidSerine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Protease Inhibitors: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).Trypsin Inhibitors: Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.Leukocyte Elastase: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.Protein C Inhibitor: A member of the serpin family of proteins that is found in plasma and urine. It is dependent on heparin and is able to inhibit activated PROTEIN C; THROMBIN; KALLIKREIN; and other SERINE ENDOPEPTIDASES.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.alpha-Macroglobulins: Glycoproteins with a molecular weight of approximately 620,000 to 680,000. Precipitation by electrophoresis is in the alpha region. They include alpha 1-macroglobulins and alpha 2-macroglobulins. These proteins exhibit trypsin-, chymotrypsin-, thrombin-, and plasmin-binding activity and function as hormonal transporters.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Science: The study of natural phenomena by observation, measurement, and experimentation.Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)Problem-Based Learning: Instructional use of examples or cases to teach using problem-solving skills and critical thinking.Curriculum: A course of study offered by an educational institution.Education, Dental: Use for articles concerning dental education in general.Myxoma: A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)Heart Neoplasms: Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.Myxoma virus: The type species of LEPORIPOXVIRUS causing infectious myxomatosis, a severe generalized disease, in rabbits. Tumors are not always present.Pigmentation DisordersAngiolymphoid Hyperplasia with Eosinophilia: Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells.Myxosarcoma: A sarcoma, usually a liposarcoma or malignant fibrous histiocytoma, with an abundant component of myxoid tissue resembling primitive mesenchyme containing connective tissue mucin. (Stedman, 25th ed)Cyclic AMP-Dependent Protein Kinase RIalpha Subunit: A type I cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP activation of protein kinase activity. It has a lower affinity for cAMP than the CYCLIC-AMP-DEPENDENT PROTEIN KINASE RIBETA SUBUNIT.Physiology: The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.Educational Measurement: The assessing of academic or educational achievement. It includes all aspects of testing and test construction.Anatomy: A branch of biology dealing with the structure of organisms.Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.Teaching: The educational process of instructing.Codon, Initiator: A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.Ericaceae: The heath plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida that are generally shrubs or small trees. Leaves are alternate, simple, and leathery; flowers are symmetrical with a 4- or 5-parted corolla of partly fused petals.BrazilMedicine in Literature: Written or other literary works whose subject matter is medical or about the profession of medicine and related areas.Helminthiasis, Animal: Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.National Institute of Child Health and Human Development (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. It now conducts and supports research on all stages of human development. It was established in 1962.Asteraceae: A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.Chrysanthemum: A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.

Genes, oxidative stress, and the risk of chronic obstructive pulmonary disease. (1/204)

BACKGROUND: The first-pass metabolism of foreign compounds in the lung is an important protective mechanism against oxidative stress. We investigated whether polymorphisms in the gene for microsomal epoxide hydrolase (mEPHX), an enzyme involved in this protective process, had any bearing on individual susceptibility to the development of chronic obstructive pulmonary disease (COPD) and emphysema. METHODS: We designed PCR-based genotyping assays to detect variant forms of mEPHX that confer slow and fast activity. We used these assays to screen 203 blood-donor controls and groups of patients with asthma (n = 57), lung cancer (n = 50), COPD (n = 68), and emphysema (n = 94), who were attending specialised clinics in Edinburgh, UK. FINDINGS: The proportion of individuals with innate slow mEPHX activity (homozygotes) was significantly higher in both the COPD group and the emphysema group than in the control group (COPD 13 [19%] vs control 13 [6%]; emphysema 21 [22%] vs 13 [6%]). The odds ratios for homozygous slow activity versus all other phenotypes were 4.1 (95% CI 1.8-9.7) for COPD and 5.0 (2.3-10.9) for emphysema. INTERPRETATION: Genetic polymorphisms in xenobiotic enzymes may have a role in individual susceptibility to oxidant-related lung disease. Epoxide derivatives of cigarette-smoke components may be the cause of some of the lung damage characteristics of these diseases.  (+info)

Giardia intestinalis is unlikely to be a major cause of the poor growth of rural Gambian infants. (2/204)

Parasite-specific plasma immunoglobulins have been used to indicate the presence of Giardia intestinalis infection in 60 infants living in a rural area of The Gambia. Infants were studied longitudinally between 2 and 8 mo of age. The median age for first exposure to G. intestinalis was between 3 and 4 mo, and by 8 mo all but 3 infants (95%) showed a positive titer on at least one occasion. Raised Giardia-specific IgM titers were associated with reduced weight gain in the 2 wk preceding a positive titer, but catch-up growth occurred in the following 2 wk. IgM antibody titers were also positively associated with intestinal permeability (lactulose/mannitol ratio), urinary lactose excretion, plasma concentrations of alpha1-antichymotrypsin and total IgM, IgA and IgG immunoglobulins. However, infant growth over the whole 6-mo period (i.e., between 2 and 8 mo of age) was not related to mean Giardia-specific antibody titers, nor the time of first exposure to the parasite. The data suggest that giardiasis in these very young breast-fed children occurs as a mild, acute disease, and its presence could not explain the marked, long-term growth faltering observed in many of the subjects.  (+info)

Anti-free prostate-specific antigen monoclonal antibody epitopes defined by mimotopes and molecular modeling. (3/204)

BACKGROUND: Prostate-specific antigen (PSA) is an important marker for the diagnosis and management of prostate cancer, and the free PSA/total PSA ratio has been shown to be efficient for distinguishing prostate cancer from benign prostatic hyperplasia. We report here the characterization of seven mouse monoclonal antibodies (mAbs) and the partial localization of two conformational epitopes identified by anti-free PSA mAbs. METHODS: The mAbs were studied by competition and sandwich assays, and the epitope localization of the two anti-free PSA mAbs (6C8D8 and 5D3D11) was performed using phage displayed peptide libraries and molecular modeling. RESULTS: The seven mAbs were classified into three groups according to their recognition specificities and their ability to inhibit the enzymatic activity of PSA and the formation of PSA-alpha1-antichymotrypsin (ACT) complex. Among the anti-free PSA mAb group, 6C8D8 recognized the phage displayed peptide RKLRPHWLHFHPVAV, two parts of which presented similarities with two regions distant on the PSA sequence but joined in the tridimensional structure. mAb 5D3D11 recognized the peptide DTPYPWGWLLDEGYD, which is similar to a PSA region located on the board of the groove containing the PSA enzymatic site. Both epitopes were located in the theoretical ACT binding site described previously. Moreover, these mAbs were able to inhibit the enzymatic activity of PSA. CONCLUSIONS: These epitope localizations are in agreement with the ability of both mAbs to inhibit enzymatic activity and ACT fixation. The results presented here could bring information for the generation of clinically relevant PSA assays.  (+info)

Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2. (4/204)

BACKGROUND: Human glandular kallikrein (hK2) is a serine protease that has 79% amino acid identity with prostate-specific antigen (PSA). Both free hK2 and hK2 complexed to alpha1-antichymotrypsin (ACT) are present in the blood in low concentrations. We wished to measure hK2 in serum with limited contribution from hK2-ACT for the results. METHODS: We developed an automated assay for hK2 with use of a select pair of monoclonal antibodies. The prototype assay was implemented on a Beckman Coulter ACCESS(R) analyzer. RESULTS: The detection limit of the assay was 1.5 ng/L, the "functional sensitivity" (day-to-day CV <15%) was <4 ng/L, cross-reactivity with PSA and PSA-ACT was negligible, and cross-reactivity with hK2-ACT was 2%. After surgical removal of prostate glands, serum hK2 was <7 ng/L and was <15 ng/L in most healthy women. The median serum concentration of hK2 in healthy men without prostate cancer was 26 ng/L. The median concentration of hK2 was 72 ng/L for men having prostate cancer with lower Gleason scores compared with 116 ng/L for men with more advanced cancer. The concentration of hK2 correlated weakly with PSA, with the mean hK2 concentrations generally 30- to 80-fold lower than PSA concentrations. CONCLUSION: The availability of a robust, high sensitivity automated assay for hK2 should facilitate further investigations of the role of hK2 measurements in the management of patients with prostate disease.  (+info)

Measurement of the complex between prostate-specific antigen and alpha1-protease inhibitor in serum. (5/204)

BACKGROUND: Prostate-specific antigen (PSA) occurs in serum both free and in complex with protease inhibitors. The complex with alpha1-antichymotrypsin (ACT) is the major form in serum, and the proportion of PSA-ACT is higher in prostate cancer (PCa) than in benign prostatic hyperplasia (BPH). PSA also forms a complex with alpha1-protease inhibitor (API) in vitro, and the PSA-ACT complex has been detected in serum from patients with prostate cancer. The aim of the present study was to develop a quantitative method for the determination of PSA-API and to determine the serum concentrations in patients with PCa and BPH. METHODS: The assay for PSA-API utilizes a monoclonal antibody to PSA as capture and a polyclonal antibody to API labeled with a Eu-chelate as a tracer. For calibrators, PSA-API formed in vitro was used. Serum samples were obtained before treatment from 82 patients with PCa, from 66 patients with BPH, and from 22 healthy females. RESULTS: The concentrations of PSA-API are proportional to the concentrations of total PSA. PSA-API comprises 1.0-7.9% (median, 2.4%) of total immunoreactive PSA in PCa and 1.3-12.2% (median, 3.6%) in BPH patients with serum PSA concentrations >4 microgram/L. In patients with 4-20 microgram/L total PSA, the proportion of PSA-API serum is significantly higher in BPH (median, 4.1%) than in PCa (median, 3. 2%; P = 0.02). CONCLUSIONS: The proportion of PSA-API in serum is lower in patients with PCa than in those with BPH. These results suggest that PSA-API is a potential adjunct to total and free PSA in the diagnosis of prostate cancer.  (+info)

Antichymotrypsin interaction with chymotrypsin. Intermediates on the way to inhibited complex formation. (6/204)

Serpins form enzymatically inactive covalent complexes (designated E*I*) with their target proteinases, corresponding most likely to the acyl enzyme that resembles the normal intermediate in substrate turnover. Formation of E*I* involves large changes in the conformation of the reactive center loop (residues P17 to P9') and of the serpin molecule in general. The "hinge" region of the reactive center loop, including residues P10-P14, shows facile movement in and out of beta-sheet A, and this movement appears to be crucial in determining whether E*I* is formed (the inhibitor pathway) or whether I is rapidly hydrolyzed to I* (the substrate pathway). Here, we report stopped-flow and rapid quench studies investigating the pH dependence of the conversion of the alpha1-antichymotrypsin.alpha-chymotrypsin encounter complex, E.I, to E*I*. These studies utilize fluorescent derivatives of cysteine variants of alpha1-antichymotrypsin at the P11 and P13 residues. Our results demonstrate three identifiable intermediates, EIa, EIb, and EIc, between E.I and E*I* and permit informed speculation regarding the nature of these intermediates. Partitioning between inhibitor and substrate pathways occurs late in the process of E*I* formation, most likely from a species occurring between EIc and E*I*.  (+info)

Comparative study of assays for prostate-specific antigen molecular forms. (7/204)

BACKGROUND: The detection of prostate-specific antigen (PSA) molecular forms such as free PSA and PSA-ACT and the use of PSA molecular ratios, especially the percentage of free to total PSA, have been reported to improve the diagnostic accuracy of prostate cancer in the patients with slightly elevated serum PSA values. However, the correlation among the values of serum free PSA or PSA-ACT obtained in various assays remains unclear. METHODS: Serum free PSA and PSA-ACT values were detected with the following assays: Hybritech, DPC, EIKEN, Abbott, Roche and Can-Ag for free PSA and Dainippon, Chugai, EIKEN and Bayer for PSA-ACT. The data obtained with each assay were compared with Hybritech (free PSA) and Dainippon (PSA-ACT) as standards. RESULTS: The free PSA data obtained with the Hybritech, EIKEN, Abbott and Can-Ag kits were similar. The values obtained with the DPC and Roche kits showed a linear regression of y = ax + b with those obtained with the Hybritech, with a b value of zero and an a value of 1.20 and 1.57, respectively. The serum PSA-ACT values detected with the Dainippon and Chugai kits were identical. The equation for converting the data obtained with the EIKEN kits to the Dainippon value was 0.7636 x (EIKEN) + 0.1381. CONCLUSIONS: Serum free PSA and PSA-ACT values obtained with various assays were not necessarily the same. Some kits for the assay of free PSA and PSA-ACT gave the same serum values. The free PSA values obtained with the other kits could be converted using appropriate equations. The gamma-Sm values showed wide variations and were not considered suitable as a measurement of free PSA.  (+info)

Effect of the ratio of free to total prostate-specific antigen on interassay variability in proficiency test samples. (8/204)

BACKGROUND: Up to sevenfold differences were observed between total prostate-specific antigen (PSA) methods for New York State Proficiency Test samples prepared with seminal fluid PSA in human female serum. Because the PSA was mainly in its free form under these conditions, we wanted to determine whether a defined mixture of free and complexed PSA would reduce the interassay differences. METHODS: We prepared a series of five solutions of 60 g/L bovine serum albumin with 10 microgram/L total PSA consisting of varied proportions of free, noncomplexible PSA, and alpha(1)-antichymotrypsin (ACT)-complexed PSA from 0% to 100%. Two hundred seventy laboratories measured the total PSA in these samples, and 16 laboratories also analyzed the samples for free PSA. The results were used to calculate free/total PSA ratios. RESULTS: Interassay CVs for total PSA measurements were approximately 7% at 10-15% free PSA but became gradually larger as the free/total PSA ratio increased. Measured free-PSA concentrations were similar within each sample (mean CV, 12%), and the results were relatively independent of the proportion of free PSA in the samples. Twofold discrepancies between actual and expected ratios were observed with some methods at 100% free PSA and to a lesser degree at 30% free PSA. At 100% free PSA, the relatively higher total-PSA values measured by nonequimolar methods yielded low free/total PSA ratios of 50-60%. In contrast, the lower total PSA values obtained by equimolar methods yielded ratios close to the expected 100%. CONCLUSIONS: Preparing proficiency test samples with a 10:90 mixture of free, noncomplexible PSA:PSA-ACT is a viable alternative to the use of seminal fluid PSA. Furthermore, the method used to measure total PSA may have a substantial impact on the calculated proportion of free PSA and hence may have clinical relevance.  (+info)

TY - JOUR. T1 - Induction of the α1-antichymotrypsin gene in the brain associated with TGF-β1 deficiency or systemic administration of endotoxin. AU - Saito, Hiroshi. AU - Shultz, Leonard D.. AU - Sinha, Mala. AU - Papaconstantinou, John. PY - 1999/9/24. Y1 - 1999/9/24. N2 - We report that mRNA levels for α1-antichymotrypsin (ACT), a component of β-amyloid plaques in Alzheimers disease, are significantly increased in the brains of two different mouse models that develop inflammation: (1) acute inflammation caused by intraperitoneal injection with lipopolysaccharide (LPS) and (2) chronic inflammation in knockout mice lacking the anti-inflammatory cytokine transforming growth factor β1 (TGF-β1). While brain mRNA levels for the inflammatory cytokines TNFα, IL-1β, and IL-6 were all elevated in the LPS-injected mice, only the mRNA for IL-1β increased significantly in TGF-β1-deficient mice. The transcription factor C/EBPβ was strongly activated in the brains of both models. These results ...
TY - JOUR. T1 - Serum alpha-2-macroglobulin, antitrypsin and antichymotrypsin activities in patients receiving treatment with cyclosporine. AU - Roche, Maya. AU - Kusumanjali, G.. AU - Chinnapu Reddy, G.. AU - Kanagasabhapathy, A. S.. AU - Rao, Pragna. PY - 2006. Y1 - 2006. N2 - Cyclosporine has been reported to function as an inhibitor of the chymotrypsin like activity of proteasome. We hypothesized that the administration of an exogenous proteinase inhibitor may affect the activities of the naturally occurring serum anti proteinases. The aim of this study was to observe the pattern of alteration of serum alpha 2 macroglobulin (AMG), alpha 1- antitrypsin (AT) and alpha 1-antichymotrypsin (ACT) activities in renal transplant patients receiving the immunosuppressive drug, cyclosporine. Patients (97) who had received a single renal allograft were inducted into the study. Subjects were on a twice-daily dosage of cyclosporine capsules. Trough (Co) and two-hour post dose (C 2) cyclosporine levels ...
G Berman, S L C Woo, D Burnett, R A Stockley; Alpha, Antichymotrypsin Synthesis by Alveolar Macrophages And Monocyte-Like Cell Lines. Clin Sci (Lond) 1 January 1987; 73 (s17): 2P. doi: https://doi.org/10.1042/cs073002P. Download citation file:. ...
Abcam provides specific protocols for Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921) : Immunohistochemistry protocols
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Starting with 1130 plasma proteins, we previously derived and then externally validated a 9 protein model (CVD9 [angiopoietin 2, complement C7, α-2 antiplasmin, matrix metalloproteinase 12, α-1 antichymotrypsin complex, growth differentiation factors 11/8, chemokine (C-C motif) ligand 18, angiopoietin related protein 4 and troponin I]) to predict 4-year probability of death, myocardial infarction, stroke and heart failure using SOMAscan proteomic technology in subjects with stable coronary heart disease (CHD). In the current study, we tested whether this proteomic risk score increases within individuals as they approach an event. We applied CVD9 to paired plasma samples from 513 subjects in the Heart and Soul study who were still event free when a second blood sample was taken 4.8 years after the first. There were 139 subjects who had events a median of 2.9 years after their second sample, compared to 374 subjects who did not have events after their second sample (with a median of 4.3 years of ...
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TY - JOUR. T1 - Amyloid-β peptide, substance P, and bombesin bind to the serpin-enzyme complex receptor. AU - Joslin, Gregg. AU - Krause, James E.. AU - Hershey, Andrew D.. AU - Adams, Steven P.. AU - Fallon, Robert. AU - Perlmutter, David H.. PY - 1991. Y1 - 1991. N2 - During the formation of an inhibitory complex with neutrophil elastase, α1 antitrypsin (α1 AT) undergoes a structural rearrangement and the resulting α1 AT-elastase complex becomes endowed with chemoattractant activities, mediates an increase in synthesis of α1 AT, and is rapidly cleared from the circulation. In previous studies we have provided evidence that these biological activities involve the recognition of a conformation-specific domain in the α1 AT molecule by a cell surface receptor on human hepatoma HepG2 cells and human monocytes. The receptor has been termed the serpin-enzyme complex (SEC) receptor because it also recognizes complexes of serpins antithrombin III, α1 anti-chymotrypsin, and C1 inhibitor with ...
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This course is designed for Japan resident. Lectures and discussions, workshop are conducted in Japanese. Save up to 10% on this course by becoming an AOCMF Member/Member Plus. If you already have an AOCMF login, click here to upgrade before registering to this course. If you dont have an AOCMF login, create a new account here , and then purchase a membership package before registering to this course. <登録用日本語 Manual > https://www.dropbox.com/sh/8uahk4hbnl0or9m/AACt9fvDTTw_Q-76l6JT1dFna?dl=0 ...
This course is designed for Japan resident. Lectures and discussions, workshop are conducted in Japanese. Save up to 10% on this course by becoming an AOCMF Member/Member Plus. If you already have an AOCMF login, click here to upgrade before registering to this course. If you dont have an AOCMF login, create a new account here , and then purchase a membership package before registering to this course. <登録用日本語 Manual > https://www.dropbox.com/sh/8uahk4hbnl0or9m/AACt9fvDTTw_Q-76l6JT1dFna?dl=0 ...
Inflammatory mechanisms contribute to neurodegeneration in AD. Acute phase proteins such as the antichymotrypsin (a1ACT), pro-inflammatory cytokines IL-6 and IL-1, and activated microglial cells are all associated with neuritic plaques. a1ACT levels are elevated in AD, correlate with cognitive decline and serve as a biological marker of intervention. a1ACT is intimately associated with the 42-AA b peptide (Ab) in filamentous amyloid deposits and stimulates the polymerization of Ab into amyloid filaments. IL-6 is found in AD cortices prior to the onset of neuritic change, serum and stimulated PMNC IL-6 levels are higher in AD, and may induce b-amyloid protein deposition. Microglia, CNS resident inflammatory cells, produce IL-6 within the adult human brain, are IL-1a +, and are a prominent component of the neuritic plaque. Because the pathogenesis of AD appears in part immune mediated, we propose testing directly in humans whether ingested IFN-a can ameliorate AD. Because there is no good model ...
Macroscopically, the tumor was of yellow-greyish color and medium consistency. Histologic examination of both the primary and recurrent tumors showed solid nests of tumor cells surrounded by a small rim of connective tissue. The neoplasm consisted of polygonal cells with abundant, eosinophilic, granular cytoplasm and relatively sharp cellular margins. Cytoplasmic granules were distinctly PAS-positive and resistant to diastase digestion. There was remarkable cellular and nuclear polymorphism with hyperchromatic nuclei and prominent nucleoli (Fig. 2).There were small areas of foamy cells and perivascular lymphocytic aggregates. Mitoses were rarely registered. The tumor was moderately vascularized. Frank necrosis was not evident. Immunohistochemically, tumor cells were strongly positive for neuron-specific enolase, S-100 protein, a1-antitrypsin and a1-antichymotrypsin (Fig. 3), but negative for glial fibrillary acidic protein, vimentin, various cytokeratins, melanoma marker HMB 45, chromogranin A, ...
article{9714ffdf-1e21-475d-ac0b-daebdc2182ca, abstract = {Clearance of the amyloid-P peptide (A beta) as a remedy for Alzheimers disease (AD) is a major target in on-going clinical trials. In vitro studies confirmed that A beta is taken up by rodent astrocytes, but knowledge on human astrocyte-mediated A beta clearance is sparse. Therefore, by means of flow cytometry and confocal laser scanning microscopy (CLSM), we evaluated the binding and internalization of A beta 1-42 by primary human fetal astrocytes and adult astrocytes, isolated from nondemented subjects (n = 8) and AD subjects (n = 6). Furthermore, we analyzed whether alpha 1-antichymotrypsin (ACT), which is found in amyloid plaques and can influence A beta fibrillogenesis, affects the A beta uptake by human astrocytes. Upon over night exposure of astrocytes to FAM-labeled A beta 1-42 (10 mu M) preparations, (80.7 +/- 17.7)% fetal and (52.9 +/- 20.9)% adult A beta-positive astrocytes (P = 0.018) were observed. No significant difference ...
A A beta 42 abl acid phosphatase ACSM1 actin-general actin-alpha cardiac actin-alpha smooth muscle actin-muscle specific AE1/AE3 (cytokeratin) AF4 AGR2 AKT1 albumin alcian blue ALK alkaline phosphatase ALL1 alpha-1-antichymotrypsin alpha-1-antitrypsin alpha-fetoprotein alpha-lactalbumin AMACR AML1 androgen receptor APC API2-MALT1 Apolipoprotein D arginase1 ATM ...
The free/total PSA ratio (%fPSA) is an additional new parameter used in assessing PSA levels. Some authors 1,2 recommend that men with PSA levels of 4.1 to 10 ng/mL who are not suspected of having prostate cancer by whatever means should undergo ...
C-Peel Delivery Serum has multiple benefits. Formulated with Vitamin C, the serum acts as a skin protector against radiations, protecting skin from oxidative damage. Stimulates collagen and elastin synthesis. Moisturises the skin. Inhibits melanogenesis and eases epithelization. Hyaluronic acid exerts a natural effect
In this lab, students will learn that even the smallest spaces can have their own climate. They will create a miniature sized terrarium and will observe how sunlight enters in order to warm the air, and in turn heat the soil and seeds. Condensation will build up in the container and the students can observe the water cycle in action, as well as the growth of the seeds over time.. ...
When cleaning your microwave-safe container after the lab is complete, you may find that sugar crystals are difficult to remove from the sides and bottom of the container. If this is the case, add hot water to your container to let the sugar crystals dissolve. You may need to empty and refill your container with hot water a few times before all the sugar crystals come out. ...
Yashraj Biotechnology is an ISO 13485:2003 certified company. Since 1999, we are engaged in manufacturing of Native & Recombinant antigens. We serve our high quality purified antigens to the worldwide, leading diagnostic companies. We currently manufacture CRP • HBsAg-Ay & Ad • CA 15-3 • CA-125 • CA 72-4 • CA 19-9 • B2M • PSA & PSA-ACT • CEA • AFP • A1M • B2M •CYS-C • PR3 • MPO • D-Dimer • NGAL • PAPP-A • sTfR • Ferritin •KFLC • LFLC • RBP. HE-4 , rec-SLO. Mabs- PSA • CRP • CA 125-3 • HbA1c. ...
Hello again - the hormone shot is doing its thing - no side effects at all - June 2018 blood work is - - PSA - <0.008 -free PSA - <0.01 - testo...
The authors acknowledge the following members of the Okayama Urological Cancer Collaborating Group; Toyoko Yamato, M.D., Ph.D. (Okayama City Hospital); Michinao Saegusa, M.D., Ph.D. (Hiroshima Citizens Hospital); Toshihiko Asahi, M.D., Ph.D. (Kagawa Prefectural Central Hospital); Bunzo Suyama, M.D., (Mitoyo General Hospital); Tadashi Oeda, M.D., Ph.D. (Onomichi Municipal Hospital); Takanori Murakami, M.D. (National Okayama Hospital); Yoshio Maki, M.D., Ph.D. (Konko Hospital); Teruaki Akaeda, M.D., Ph.D. (Tsuyama Central Hospital); Masatoshi Noda, M.D., Ph.D. (Saint Maria Hospital); Teruhisa Ohashi, M.D., Ph.D. (Okayama Redcross Hospital); and Masahiro Hara, M.D., Ph.D. (Fukuyama Municipal Hospital). ...
Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O. A complex between prostate-specific antigen and α1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res 1991; 51: 222-6 ...
Since 1987 her research has focused on the serpin family of SERine PRoteinase INhibitors, which play important regulatory roles in vivo. They now recognise that the physicochemical properties of the serpin structure that confer protease inhibitor activity also render these proteins sensitive to post-translational modifications (i.e. oxidation, nitrosylation, inter- or intramolecular interactions and non-specific cleavage). These altered forms of inhibitory serpins are detected in tissues and fluids recovered from inflammatory sites, but the important questions of how they are generated, what their biological activities are, and which of them are directly linked to pathologies and/or may be useful markers for characterisation of disease states, remain to be answered. Her objective is to address this challenge, focusing on the role of native (inhibitory) and post-translationally modified (non-inhibitory) forms of Alpha1-Antitrypsin in obstructive pulmonary disease and Alpha1-antichymotrypsin in ...
The superfamily of ser ine p roteinase in hibitors (serpins) is involved in numerous fundamental biological processes as inflammation, blood coagulation and apoptosis. Our interest is focused on the SERPINA3 sub-family. The major human plasma protease inhibitor, α1-antichymotrypsin, encoded by the SERPINA3 gene, is homologous to genes organized in clusters in several mammalian species. However, although there is a similar genic organization with a high degree of sequence conservation, the reactive-centre-loop domains, which are responsible for the protease specificity, show significant divergences. We provide additional information by analyzing the situation of SERPINA3 in the bovine genome. A cluster of eight genes and one pseudogene sharing a high degree of identity and the same structural organization was characterized. Bovine SERPINA3 genes were localized by radiation hybrid mapping on 21q24 and only spanned over 235 Kilobases. For all these genes, we propose a new nomenclature from SERPINA3-1 to
Serpins (serine protease inhibitors) comprise a superfamily of more than forty proteins which are implicated in various regulatory cascades in vivo such as blood coagulation, fibrinolysis, complement activation, matrix proteolysis, and inflammation. Since these 45 kD proteins undergo a massive beta-sheet rearrangement during the course of their biological function, serpins are intriguing from the perspectives of protein folding as well as medical relevance. Antichymotrypsin has been engineered to be an inhibitor of human neutrophil elastase in vitro, and the engineered serpin exhibits antiinflammatory properties in vivo. We have determined the structure of this serpin, and current work focuses on a structure-assisted approach toward engineering the specificity and stability of the active serpin. Additionally, we will determine the structure of the serpin in its complex with a target serine protease, and we will also determine the structures of other members of the serpin superfamily, e.g., those ...
The activity of proteases is inhibited by protease inhibitors.[18] One example of protease inhibitors is the serpin superfamily. It includes alpha 1-antitrypsin (which protects the body from excessive effects of its own inflammatory proteases), alpha 1-antichymotrypsin (which does likewise), C1-inhibitor (which protects the body from excessive protease-triggered activation of its own complement system), antithrombin (which protects the body from excessive coagulation), plasminogen activator inhibitor-1 (which protects the body from inadequate coagulation by blocking protease-triggered fibrinolysis), and neuroserpin.[19] Natural protease inhibitors include the family of lipocalin proteins, which play a role in cell regulation and differentiation. Lipophilic ligands, attached to lipocalin proteins, have been found to possess tumor protease inhibiting properties. The natural protease inhibitors are not to be confused with the protease inhibitors used in antiretroviral therapy. Some viruses, with ...
In this study, we focused on four glial proteins that are abundant in amyloid plaques and/or that are known to interact with Abeta: alpha1-antichymotrypsin (ACT), interleukin-1beta (IL-1beta), S100beta, and butyrylcholinesterase (BChE). We examined the ability of these proteins to activate rat cortical astrocyte cultures and to influence the ability of Abeta to activate astrocytes. Treatment of astrocytes with ACT, IL-1beta, or S100beta resulted in glial activation, as assessed by reactive morphology, upregulation of IL-1beta, and production of inducible nitric oxide synthase and nitric oxide. The ability of Abeta to induce astrocyte activation was also enhanced in the presence of each of these three proteins. In contrast, BChE alone did not activate astrocytes and had no effect on Abeta-induced activation ...
14.3.3 Pan, Acinus, AIF (Apoptosis Inducing Factor), Alpha-1-antichymotrypsin, alpha-1-antitrypsin, ARC, Ask1/MAPKKK5, ATM, BAG-1, Bak, Bax, Bcl10/CIPER/CLAP/mE10, bcl-2a, Bcl-6, bcl-X, bcl-XL, Bim (BOD), Caspase 1, Caspase 2, Caspase 3, Caspase 5, Caspase 6 (Mch 2), Caspase 7 (Mch 3), Caspase 8 (FLICE), Cathepsin D, CD137 (4-1BB), CD14, CD95/Fas, CDK2, CDK4, CDK5, c-fos, CIDE-A, CIDE-B, c-jun, CREB, CREB-Binding Protein, Cytochrome c, D4-GDI, Daxx, DcR1, DcR2/TRAIL-R4/TRUNDD, DFF40 (DNA Fragmentation Factor 40)/CAD, DFF45/ICAD, DR3, DR5, ERK1, ERK2, FADD (FAS-Associated death domain-containing protein), Fas-ligand, FLIP, Granzyme B, Heat Shock Protein 70/hsp70, I-FLICE/CASPER, IGF-1R, IGF-I, I-Kappa-B Kinase b (IKKb), JNK Activating kinase (JKK1), MADD, Mcl-1, Mekk-1, NF kappa B/p50, NF kappa B/p65 (Rel A), p53, PARP, PARP (Poly ADP-Ribose Polymerase), Prohibitin, RAIDD, SODD (Silencer of Death Domain), Survivin, TNF alpha, TNFa, ...
Armstrong RA, Winsper SJ, Blair JA (1995) Hypothesis: is Alzheimers disease a metal_induced immune disorder? Neurodegeneration 4:107_111 Bennett SA, Stevenson B, Staines WA, Roberts DC (1995) Periodic acid_Schiff (PAS)_positive deposits in brain following kainic acid_induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood_brain barrier breakdown. Acta Neuropathol Berl 89:126_138 Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross_linking in Alzheimer disease. Acta Neuropathol Berl 89:291_295 Das S, Potter H (1995) Expression of the Alzheimer amyloid_promoting factor antichymotrypsin is induced in human astrocytes by IL_1. Neuron 14:447_456 De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute ...
Urticaria cholinergic is another type of the Urticaria that is caused by a certain physical stimulus of some or of the other class. It is classified like physical urticaria, meaning that is caused by a physical stimulus of a certain class. The physical stimulus could be indicated as heat although the real cause is defined as sweating. The study of the activity of the cell of the mast includes Urticaria generally cholinergic because most of the cases of Urticaria cholinergic looks like to critically imply the cells of the mast. The main mediator is the histamina of the serum, that rises in the concentration when an induced test exercise is introduced. This treatment also implies quimiotácticos factors eosinophil and of the neutrophil as well as it tryptase. The levels of the alpha 1-antichymotrypsin diminish, and the use of danazol gives rise to the improvement in the eruption. Due to these results, some have discussed in please proteases like a cause of the histamina that was sent. The skin ...
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Unique and highly effective blend of active ingredients in this Age-defying Serum create nourishment for mature and fatigue skin to gain back its visible youthful contours. This Serum works in two directions: in one way it is increasing skins firmness, elasticity and daily level of moisture, thus prolonging skins vitality and good looks, while at the same time reducing the depth of existing lines caused by unavoidable stress or simply by time passing by. Mature and fatigue skin usually have identical background - dryness - and it is precisely why Age-defying serum approaches nourishment of mature skin to reduce already visible signs of time and to help replace, increase and maintain skins qualities of youth. Abundance of active ingredients composed to fit precisely aging skin are presented in a light and natural formula, with plenty of moisture. High intake of probiotics in this Age-defying Serum act to stimulate repair of skins barrier, increase its natural defense and immune system, ...
Serpins: A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.
Polymorphonuclear neutrophils (PMN) play an important role in myocardial ischemia/reperfusion (MI/R) injury; however, the role of neutrophilic proteases is less understood. The effects of a novel serine protease inhibitor (serpin), LEX032, were investigated in a murine model of MI (20 min) and R (24 hr) injury in vivo. LEX032 is a recombinant human alpha 1-antichymotrypsin in which six amino acid residues were replaced around the active center with those of alpha-1 protease inhibitor. LEX032 has the ability to inhibit both neutrophil elastase and cathepsin G, two major neutral serine proteases in neutrophils, as well as superoxide generation. LEX032 (25 or 50 mg/kg) administered i.v. 1 min before reperfusion significantly attenuated myocardial necrotic injury evaluated by cardiac creatine kinase loss compared to MI/R rats receiving only vehicle (P , .001). Moreover, cardiac myeloperoxidase activity, an index of PMN accumulation, in the ischemic myocardium was significantly attenuated by LEX032 ...
... ,, PSA exists in multiple forms in the blood. Most is bound to proteins, but some is free-floating. In the early 1990s, it was discovered that measuring the ratio of free to total PSA could furth,medicine,medical supply,medical supplies,medical product
Objectives: Compose a list toxins causing metabolic acidosis and hemodynamic instability Describe therapeutic interventions favoring aerobic metabolismin hemodynamically unstable patients Describe the mechanisms for paracetamol-inducedearly metabolic acidosis Outline the management of the...
Prostate cancer free psa - PSA: At a Glance | Prostate Specific Antigen. Prostacet provides a comprehensive blend of Vitamins, minerals and standardized herbal extracts designed to support healthy prostate function.
河南快36号开奖结果:The total PSA (prostate-specific antigen, prostate-specific antigen) value in serum of normal people is <4.0ng/ml; if >10.0ng/ml, the probability of prostate cancer is very high. Between 4.0 to ...
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Objectives. Improved discrimination between prostate cancer (PC) and benign prostatic hyperplasia (BPH) is clearly needed. Our aim in this study was to evaluate whether the free to total prostate-specific antigen (PSA) ratio would be useful in the gray zone of 1.8-10 ng/mL total PSA range. Methods. In a consecutive series of 435 clinic patients referred for prostate evaluation, 308 had a total PSA ,10 ng/mL (92 had PC and 216 BPH). Free and total PSA were measured, and the free to total PSA ratio calculated. Results. Total PSA values were significantly different between the two groups. For the 200 patients with a total PSA ,6 ng/mL, no significant difference in total PSA values were seen (P = 0.411), whereas free to total PSA ratios remained statistically different (P , 0.001). Receiver operating characteristic (ROC) curve analysis comparing the performances of total PSA over the ratio of free to total PSA showed a clear advantage for the ratio at all sensitivity levels. Conclusions. These data ...
The mustard trypsin inhibitor, MTI-2, is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for lepidopteran insects, but has low activity against aphids. In an attempt to improve the activity of the inhibitor towards aphids, a library of inhibitor variants was constructed and cloned into the pRlac3 phagemid vector. The library of 9.3 x 107 independent colonies was created by randomisation of a stretch of five consecutive codons in the reactive site. Repeated selection rounds against bovine trypsin and chymotrypsin allowed the identification of novel, MTI-2 derived, antitrypsin and antichymotrypsin inhibitors. Chy8, the selected variant with highest affinity for bovine chymotrypsin (Ki = 32 nm versus |1000 nm for the wild-type) represents the strongest known recombinant chymotrypsin inhibitor of the MTI-2 family. It is highly toxic to nymphs of the aphid Acyrthosiphon pisum, and moderately toxic to nymphs of Aphis gossypii and Myzus persicae. The LC50 of 73 microg ml-1
Several PSA isoforms have been identified that can further increase the specificity of PSA for prostate cancer. In particular, the [-2] form of proPSA (p2PSA) shows improved performance over either total or free PSA for prostate cancer detection on biopsy. The prostate health index (phi) is a formula that combines all 3 PSA forms (total PSA, free PSA, and p2PSA) into a single score. Phi is calculated using the following formula: (p2PSA/free PSA) x square root (PSA).. In a multicenter study that compared the performance of PSA, free PSA, p2PSA, and phi in men undergoing prostate biopsy due to a serum PSA concentration between 4 and 10 ng/mL, phi was the best predictor of any prostate cancer, high-grade cancer, and clinically significant cancer. At 95% clinical sensitivity, the clinical specificity of phi was 16.0%, compared to 8.4% for free PSA and 6.5% for PSA.. Prostatic biopsy is required for diagnosis of cancer.. ...
How is it used?. If prostate cancer is diagnosed, the total PSA test may be used as a monitoring tool to help determine the effectiveness of treatment. It may also be ordered at regular intervals after treatment to detect recurrence of the cancer.. The total PSA test and digital rectal exam (DRE) may be used to screen both asymptomatic and symptomatic men for prostate cancer. If either the PSA or the DRE are found to be abnormal, then the doctor may choose to follow this testing with a prostate biopsy and perhaps imaging tests, such as an ultrasound. If the DRE is normal but the PSA is moderately elevated, the doctor may order a free PSA test to look at the ratio of free to total PSA. This can help to distinguish between prostate cancer and other non-cancer causes of elevated PSA. Since the total PSA test can be elevated temporarily for a variety of reasons, a doctor may order another PSA a few weeks after the first to determine if the PSA is still elevated.. Currently there is no consensus ...
Plays a role in setting standards of care for HIV infection and opportunistic diseases related to HIV/AIDS. Find information about the AACT, annual reports and structures and operations of the committees. ...
Keep up-to-date with whats happening with FPSA, our members and the industry. We post relevant articles and keep them continuously updated.
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Looking for serine proteinase inhibitor? Find out information about serine proteinase inhibitor. A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process. Explanation of serine proteinase inhibitor
2006). "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4". Biochem. Biophys. Res. Commun ... DNAJC1 has been shown to interact with Alpha 1-antichymotrypsin. GRCh38: Ensembl release 89: ENSG00000136770 - Ensembl, May ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 domain of ... 83 (1): 153-67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ...
Mellon MB, Frank BT, Fang KC (2002). "Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving ... Caughey GH, Raymond WW, Wolters PJ (2000). "Angiotensin II generation by mast cell alpha- and beta-chymases". Biochim. Biophys ... 1993). "Reaction of human chymase with reactive site variants of alpha 1-antichymotrypsin. Modulation of inhibitor versus ... 286 (1): 163-73. doi:10.1006/jmbi.1998.2462. PMID 9931257. Pereira PJ, Wang ZM, Rubin H, et al. (1999). "The 2.2 A Crystal ...
Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro- ... 1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein". Arch. Biochem. Biophys ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Yoshikawa W, Hara H, Takehara T, et al. ( ...
Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (Oct 2003). "Alpha-synuclein degradation by serine ... antichymotrypsin". Clinical Chemistry. 49 (5): 746-51. doi:10.1373/49.5.746. PMID 12709365. Magklara A, Mellati AA, Wasney GA, ... "Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)- ... 1350 (1): 11-4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis ...
The genetic code of protein C inhibitor is similar to alpha 1-antitrypsin and alpha 1-antichymotrypsin. The in vivo half time ... Hayashi S, Wakizaka A (July 1995). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen". Blood ... Billingsley GD, Walter MA, Hammond GL, Cox DW (February 1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, ... alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome ...
PSA exists in serum in the free (unbound) form and in a complex with alpha 1-antichymotrypsin; research has been conducted to ... ISBN 1-891276-02-6. [dead link] Catalona WJ, Richie JP, Ahmann FR, Hudson MA, Scardino PT, Flanigan RC, deKernion JB, Ratliff ... 154 (2 Pt 1): 407-13. doi:10.1016/S0022-5347(01)67064-2. PMID 7541857. Crawford ED, Schutz MJ, Clejan S, Drago J, Resnick MI, ... 148 (1): 83-6. PMID 1377290. Collins GN, Martin PJ, Wynn-Davies A, Brooman PJ, O'Reilly PH (May 1997). "The effect of digital ...
1996). "Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced ... Brecher AS, Yang MP (1998). "Acetaldehyde inhibits chymotrypsin and serum anti-chymotrypsin activity". J. Investig. Med. 46 (4 ... 195 (1-2): 27-39. doi:10.1016/0009-8981(90)90191-T. PMID 2093478. Masson E, Chen JM, Scotet V, et al. (2008). "Association of ... 123 (1): 83-91. doi:10.1007/s00439-007-0459-3. PMID 18172691. Rosendahl J, Witt H, Szmola R, et al. (2008). "Chymotrypsin C ( ...
alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder". The New England Journal of Medicine. 309 (12 ... The X-ray crystal structures of antithrombin, heparin cofactor II, MENT and murine antichymotrypsin reveal that these serpins ... Lomas DA, Evans DL, Finch JT, Carrell RW (June 1992). "The mechanism of Z alpha 1-antitrypsin accumulation in the liver". ... Initial research focused on their role in human disease: alpha 1-antitrypsin deficiency is one of the most common genetic ...
"Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1- ... antichymotrypsin and is stimulated by proteinases". The Journal of Experimental Medicine. 168 (4): 1293-306. doi:10.1084/jem. ... If the sn-1 was removed then PAF lacked any sort of biological activity. Finally, the sn-3 position of PAF was experimented ... 10 (1): 1-6. doi:10.1385/ENDO:10:1:1. PMID 10403564. Yaras N, Ugur M, Ozdemir S, Gurdal H, Purali N, Lacampagne A, Vassort G, ...
... alpha-crystallin a chain MeSH D12.776.306.366.100.300 - alpha-crystallin b chain MeSH D12.776.306.366.300.100 - beta-crystallin ... steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 ... Retinoid X receptor alpha MeSH D12.776.826.701.500.625 - Retinoid X receptor beta MeSH D12.776.826.701.500.750 - Retinoid X ... interferon-alpha MeSH D12.776.467.750.500.250.100 - interferon alfa-2a MeSH D12.776.467.750.500.250.150 - interferon alfa-2b ...
... alpha-macroglobulins MeSH D12.776.124.790.720.100.500 -- pregnancy-associated alpha 2-macroglobulins. ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.114.619.251 -- immunoglobulin d MeSH D12.776.124.486.485.114.619.251.500 ... immunoglobulin alpha-chains MeSH D12.776.124.486.485.705.500.360 -- immunoglobulin delta-chains MeSH D12.776.124.486.485.705. ... alpha-macroglobulins MeSH D12.776.124.790.106.118 -- antiplasmin MeSH D12.776.124.790.106.125 -- antithrombin iii MeSH D12.776. ...
Turk B, Brieditis I, Bock SC, Olson ST, Björk I (1997). "The oligosaccharide side chain on Asn-135 of alpha-antithrombin, ... alpha 1-antichymotrypsin and MENT. The conformational change most relevant for Factor IXa and Xa inhibition involves the P14 ... alpha 2-antiplasmin and Heparin cofactor II. The physiological target proteases of antithrombin are those of the contact ... 7 (1): 27-35. doi:10.1111/j.1365-2362.1977.tb01566.x. PMID 65284. Conard J, Brosstad F, Lie Larsen M, Samama M, Abildgaard U ( ...
It includes alpha 1-antitrypsin (which protects the body from excessive effects its own inflammatory proteases), alpha 1- ... antichymotrypsin (which does likewise), C1-inhibitor (which protects the body from excessive protease-triggered activation of ... 568: 1-5. Woessner, edited by Alan J. Barrett, Neil D. Rawlings, J. Fred (2004). Handbook of proteolytic enzymes (2nd ed.). ... 151 (1): 13-25. doi:10.1093/jb/mvr129. PMID 22016395. N D Rawlings and A J Barrett (1993). "Evolutionary families of peptidases ...
Obligate heterodimers of one alpha and one beta subunits Alpha subunits A1 A2 A3 A4 A5 A6 A7 A8 A9 A10 A11 AD AE AL (CD11a) AM ... Alpha-v beta-3 Alpha-v beta-5 Immunoglobulin superfamily CAMs SynCAMs - Synaptic cell adhesion molecules NCAMs - Neural cell ... Fc-alpha receptors (FcαR) FcαRI (CD89, FCAR) Fcα/μR Fc-epsilon receptors (FcεR) FcεRI - Tetramer: FCER1A / FCER1B / two FCER1G ... Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3 Ferritin Fibrin ...
"Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin". Biochemical Society ... Recombinant alpha-1 antitrypsin is not yet available for use as a drug but is under investigation as a therapy for alpha-1 ... Alpha-1-antitrypsin or α1-antitrypsin (A1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in ... The alpha region can be further divided into two sub-regions, termed "1" and "2". Alpha-1 antitrypsin is the main protein of ...
The alpha globulins typically have molecular weights of around 93 kDa. α1-antitrypsin Alpha 1-antichymotrypsin Orosomucoid ( ... Haptoglobin Alpha-2u globulin α2-macroglobulin Ceruloplasmin Thyroxine-binding globulin Alpha 2-antiplasmin Protein C Alpha 2- ... Alpha globulins are a group of globular proteins in plasma that are highly mobile in alkaline or electrically charged solutions ... lipoprotein Angiotensinogen Alpha-Globulins at the US National Library of Medicine Medical Subject Headings (MeSH). ...
... (symbol α1AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin ... Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in ... Alpha-1 antitrypsin, another serpin that is analogous for protecting the body from excessive effects of its own inflammatory ... Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of ...
Tsuda M, Masuyama M, Katsunuma T (1986). "Inhibition of human DNA polymerase alpha by alpha 1-antichymotrypsin". Cancer Res. 46 ... DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene. Pol α has limited processivity ... DNA dependent polymerase alpha (Pol α) has been shown to interact with Retinoblastoma protein, PARP1 and RBMS1. DNA Polymerase ... Wong SW, Wahl AF, Yuan PM, Arai N, Pearson BE, Arai K, Korn D, Hunkapiller MW, Wang TS (1988). "Human DNA polymerase alpha gene ...
Also in this reaction, the C3 hydroxyl group will remove a phosphate from the alpha carbon of phosphoenolpyruvate. This creates ... "Retrieved 1 May 2011.. *^ a b c d e f g h White, D. (2007). The physiology and biochemistry of prokaryotes (3rd ed.). NY: ... The sugar component consists of alternating residues of β-(1,4) linked N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM ... The peptide chain can be cross-linked to the peptide chain of another strand forming the 3D mesh-like layer.[1] Peptidoglycan ...
7 (1): 29759. doi:10.3402/jom.v7.29759. ISSN 2000-2297.. *^ Li Y, Martin LD, Spizz G, Adler KB (November 2001). "MARCKS protein ... 44 Suppl 1 (1): 5-9. doi:10.1080/713713622. PMID 12952166.. *^ Midura RJ, Hascall VC (October 1996). "Bone sialoprotein--a ... Mucins are secreted as massive aggregates of proteins with molecular masses of roughly 1 to 10 million Da. Within these ... 1] Some mucins are associated with controlling mineralization, including nacre formation in mollusks,[2] calcification in ...
... s are proteins[1] that are heavily glycosylated. The basic proteoglycan unit consists of a "core protein" with one ...
Alpha-fetoprotein. *Erythropoietin (EPO). Functions[edit]. Some functions served by glycoproteins[4]:524 Function Glycoproteins ... N-linked protein glycosylation (N-glycosylation of N-glycans) at Asn residues (Asn-x-Ser/Thr motifs) in glycoproteins.[1] ... Crispin, Max; Doores, Katie J (1 April 2015). "Targeting host-derived glycans on enveloped viruses for antibody-based vaccine ... "Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers". Cell Reports. 11 (10): 1604-1613. doi:10.1016/j ...
Interferon alpha (interferon alfa, IFN-α). *Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, ... 4-1BB is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily, expressed on activated T Lymphocytes.[1 ...
The chemical structures of the ligands are Ca2+ ion, alpha-D-mannose (C6H12O6), and D-glucosamine (C6H13NO5). ... The structure is mainly made up of single alpha helices shown in red and beta sheets shown in yellow. The two blue structures ... These platelets have thrombin receptors on their surfaces that bind serum thrombin molecules[1] which in turn convert soluble ...
64 (1): 37-43. PMC 1385183 . PMID 2454887.. *^ Goodison S, Urquidi V, Tarin D (Aug 1999). "CD44 cell adhesion molecules". ... 17 (1): 3-14. doi:10.1038/sj.cr.7310118. PMID 17179981.. *^ Sillanpää S, Anttila MA, Voutilainen K, Tammi RH, Tammi MI, ... 4 (1): 33-45. doi:10.1038/nrm1004. PMID 12511867.. *. Martin TA, Harrison G, Mansel RE, Jiang WG (May 2003). "The role of the ... 230 (1): 51-74. doi:10.1111/j.1600-065X.2009.00792.x. PMC 4306344 . PMID 19594629.. ...
The protein is composed of alpha helices and beta sheets that form two domains.[8] The N- and C- terminal sequences are ... Alpha globulins. .mw-parser-output .nobold{font-weight:normal}. serpins:. *alpha-1 (Alpha 1-antichymotrypsin, Alpha 1- ... 7 (1): 41-52. doi:10.2174/187152808784165162. PMID 18473900.. *^ PDB: 1suv​; Cheng Y, Zak O, Aisen P, Harrison SC, Walz T (Feb ... The affinity of transferrin for Fe(III) is extremely high (association constant is 1020 M−1 at pH 7.4)[7] but decreases ...
Alpha 1-antichymotrypsin (symbol α1AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin ... Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in ... Alpha-1 antitrypsin, another serpin that is analogous for protecting the body from excessive effects of its own inflammatory ... Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimers disease as it enhances the formation of ...
Goat polyclonal alpha 1 Antichymotrypsin antibody validated for WB and tested in Human. Immunogen corresponding to synthetic ... All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab223226) at 0.3 µg/ml. Lane 1 : Human albumin-depleted serum lysate (in ... Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the ... Anti-alpha 1 Antichymotrypsin antibody. See all alpha 1 Antichymotrypsin primary antibodies. ...
Abcam provides specific protocols for Anti-alpha 1 Antichymotrypsin antibody, prediluted (ab921) : Immunohistochemistry ...
Avhandlingar om ALPHA-1-ANTICHYMOTRYPSIN. Sök bland 88530 avhandlingar från svenska högskolor och universitet på Avhandlingar. ... alpha-1-antichymotrypsin. . *. 1. Metabolism of free and complexed prostate - specific antigen and their utility for diagnosis ... 3. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders. Detta är en ... Sammanfattning : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver ...
Browse our Serpin A3/alpha 1-Antichymotrypsin Protein catalog backed by our Guarantee+. ... Serpin A3/alpha 1-Antichymotrypsin Proteins available through Novus Biologicals. ... Our Serpin A3/alpha 1-Antichymotrypsin Peptides and Serpin A3/alpha 1-Antichymotrypsin Proteins can be used in a variety of ... Serpin A3/alpha 1-Antichymotrypsin Proteins. We offer Serpin A3/alpha 1-Antichymotrypsin Peptides and Serpin A3/alpha 1- ...
Alpha-1-antichymotrypsin / ACT (full length) antibody. Not available. Mouse. IgG1. 1E6. Purified. Hu. E, IP, P, WB. 50 µg / € ... Background of Alpha-1-antichymotrypsin / ACT antibody. SERPI3 is a plasma protease inhibitor and member of the serine protease ... Alternative names for Alpha-1-antichymotrypsin / ACT antibody. SERPINA3, AACT, GIG24, GIG25, Cell growth-inhibiting gene 24/25 ... Recombinant human Alpha-1-antichymotrypsin (24-423 aa), His-tagged: 15% SDS-PAGE (3 µg). *AR09303PU-L ...
Alpha 1 Antichymotrypsin Antigen-NP_001076.2 (MBS568719) product datasheet at MyBioSource, Antigens. Application: Immunogen ... Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of ... Hexokinase 1 (HK2) Antibody. • TGM2 (Transglutaminase 2, Tissue) CLIA Kit. • B-Raf Proto Oncogene Serine-Threonine Protein ... both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human ...
Optimized DNA sequence encodingHuman alpha 1 antichymotrypsin -AACT (HIS23 - ALA423) mature chain including a C-terminal His ... Human alpha 1 antichymotrypsin Recombinant. Home/Cytokines/Human reagents/Recombinant Human Cytokines/Human alpha 1 ... Recombinant Human alpha 1 antichymotrypsin (AACT) can be stored in working aliquots at 2° - 8° C for one month, or at -20°C to- ... Recombinant human alpha 1 antichymotrypsin(AACT) is lyophilized from 0.2 μm filtered PBS solution, pH7.2 , 5% Trehalose. ...
... alpha 1 Antichymotrypsin抗体一覧…画像、プロトコール、文献などWeb上の情報 ... All lanes : Anti-alpha 1 Antichymotrypsin antibody (ab107362) at 1 µg/ml. Lane 1 : Human spinal cord tissue lysate - total ... Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the ... alpha 1 Antichymotrypsin contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a
Buy online Recombinant Human Alpha-1 AntiChymotrypsin Protein from Prospec cat# pro-750. ProteoGenix provides you the best ... More info about Recombinant Human Alpha-1 AntiChymotrypsin Protein. Catalog#: pro-750. ...
Expression of alpha-1-antichymotrypsin in prostate carcinoma. In: Journal of Korean medical science. 1997 ; Vol. 12, No. 3. pp ... Expression of alpha-1-antichymotrypsin in prostate carcinoma. / Cho, Nam Hoon; Park, Chanil; Park, Dong Soo. ... Cho, N. H., Park, C., & Park, D. S. (1997). Expression of alpha-1-antichymotrypsin in prostate carcinoma. Journal of Korean ... Cho, NH, Park, C & Park, DS 1997, Expression of alpha-1-antichymotrypsin in prostate carcinoma, Journal of Korean medical ...
Human Alpha 1_Anti_Chymotrypsin ELISA \ KT-498 for more molecular products just contact us ... Anti_Chymotrypsin ELISA. Related products : Human Alpha 1_Anti_Chymotrypsin ELISA ... Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha). [HBB] Hemoglobin subunit beta (Beta-globin) ( ... WP1047: TNF-alpha NF-kB Signaling Pathway. WP1120: Ovarian Infertility Genes. WP1163: TNF-alpha NF-kB Signaling Pathway. WP1209 ...
A1 Antichymotrypsin, AACT, ACT, Alpha 1 antichymotrypsin, GIG24, GIG25, Serpin A3, SERPINA3. Host Mouse. Reactivity Human. ... A1 Antichymotrypsin, AACT, ACT, Alpha 1 antichymotrypsin, GIG24, GIG25, Serpin A3, SERPINA3. Observed MW. 60 kDa. ... anti- alpha 1 Antichymotrypsin / AACT antibody. Catalogue No.. FNab00318. Size. 100µg. Form. liquid. Purification. Protein A+G ... anti- alpha 1 Antichymotrypsin / AACT antibody Statement. Manuals on the web are for your reference only, specifications are ...
... both of which can convert angiotensin-1 to the active angiotensin-2. UniProt ...
Alpha-1-antichymotrypsin gene polymorphism and susceptibility to multiple system atrophy (MSA).. Furiya Y1, Hirano M, ... We investigated three genotypes (AA, AT, and TT) produced by signal peptide polymorphism of the alpha-1-antichymotrypsin (ACT) ... 1. Department of Neurology, Nara Medical University, Medial School, Kashihara, Nara 634-8521, Japan. [email protected] ...
Apolipoprotein E and alpha-1-antichymotrypsin polymorphisms in sporadic inclusion body myositis.. Gossrau G1, Gestrich B, Koch ... alpha1-antichymotrypsin (alpha1-ACT) and apolipoprotein E (ApoE). Polymorphisms and mutations of the encoding genes have been ... 1. Department of Neurology, Medical Clinic II, Technical University Dresden, Dresden, Germany. [email protected] ...
The form and Function of Alpha1 Antichymotrypsin in Plasma and Lung Secretions. G. Berman, R.A. Stockley, S.C. Afford, D. ... The form and Function of Alpha1 Antichymotrypsin in Plasma and Lung Secretions ... The form and Function of Alpha1 Antichymotrypsin in Plasma and Lung Secretions ... The form and Function of Alpha1 Antichymotrypsin in Plasma and Lung Secretions ...
USE OF ANTIBODIES TO MODIFIED ALPHA 1 ANTICHYMOTRYPSIN. Amount: $50,000.00 ALZHEIMERS DISEASE (AD), A LEADING HEALTH PROBLEM ... RAPID ASSAY FOR HUMAN A(1)-PROTEINASE INHIBITOR DEFICIENCY. Amount: $500,000.00 THIS PROPOSAL INVOLVES THE DEVELOPMENT OF A ... SIMPLE ASSAY FORMEASURING FUNCTIONAL (1)-PROTEINASE INHIBITOR LEVELS IN HUMAN TISSUES. THE PROCEDURE UTILIZES THE FACT THAT ...
Proteínas de fase aguda (es); Beljakovina akutne faze (sl); Protéine de phase aiguë (fr); protein akutní fáze (cs); Akutfasprotein (sv); Białka ostrej fazy (pl); پروتئین فاز حاد (fa); acutefase-eiwit (nl); Akūtas fāzes olbaltumi (lv); Proteina di fase acuta (it); Akute-Phase-Protein (de); Proteínas de fase aguda (pt); Acute-phase protein (en); بروتين طور حاد (ar); 急性期蛋白 (zh); Akutfaseprotein (da) Proteinas de fase aguda (es); Réaction de phase aiguë, Proteine de phase aigue (fr); Akute-Phase-Proteine, Akut-Phase-Protein (de); Akutfasproteiner (sv); protein akutního stavu, proteiny akutní fáze, reaktant akutní fáze, reaktanty akutní fáze (cs); 急相蛋白 (zh); acuut fase eiwit, acute-fase eiwit (nl ...
Alpha-1-antitrypsin immunological test system.. II. 866.5150. Bence-Jones proteins immunological test system.. II. ...
Joseph J Maleszewski, MD is a member of the following medical societies: Alpha Omega Alpha, College of American Pathologists, ... Myxoma cells exhibit immunoreactivity to calretinin (75-100%), vimentin (, 50%), and alpha-1 antichymotrypsin. [37, 21, 38] ... Cardiac myxomas have shown to be variably immunoreactive to S-100, smooth muscle actin, desmin, alpha-1 antitrypsin, ... 1, 11, 27] Such symptoms may include fever, arthralgia, myalgia, and weight loss. [23] Laboratory findings may include elevated ...
Alpha-1 Acid Glycoprotein 1 (Human) ELISA Kit. Catalog #: E4783 , Datasheet $740.00 ...
Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism.. Klimkowicz A, Słowik A, Dziedzic T, Polczyk R ...
Rights & permissionsfor article DEFICIENCY OF ALPHA-1-ANTICHYMOTRYPSIN IN ASTHMATIC CHILDREN . Opens in a new window. ... 1 October 1985 THEOPHYLLINE CONCENTRATION MEASUREMENTS IN SERUM OR SALIVA FOR THERAPY MONITORING IN BRONCHIAL ASTHMA *W Leupold ... 1 June 1983 Airway Resistance, Airway Conductance, Specific Airway Resistance, and Specific Airway Conductance in Children *M ... 1 September 1989 PERCUTANEOUS ENDOSCOPIC CONTROLLED GASTROSTOMY (PEG) FOR ALIMENTATION OF CHILDREN WITH CYSTIC FIBROSIS *B ...
Alpha-antichymotrypsin gene polymorphism and risk for Alzheimers disease in the Spanish population.. Neurosci Lett. 1998 Jan 9 ... Analysis of the coding and the 5 flanking regions of the alpha-synuclein gene in patients with Parkinsons disease.. Mov ... Alpha1-antichymotrypsin gene polymorphism and susceptibility to Parkinsons disease.. Neurology. 1999 Jan 15;52(2):297-301 ... Alpha(1)-antichymotrypsin gene polymorphism in patients with stroke.. Stroke. 2000 Sep;31(9):2103-5 ...
  • Lymphocytic infiltration of the orbital tissue causes a release of cytokines (eg, tumor necrosis factor [TNF], interleukin 1 [IL-1]) from CD4+ T cells stimulating the orbital fibroblasts to produce mucopolysaccharides, which, by hyperosmotic shift, cause tissue edema in the extraocular muscles. (medscape.com)
  • We report a case of a noncystic fibrosis bronchiectasis patient in the absence of emphysema associated with low serum alpha-1-antitrypsin (AAT) level, in the absence of the most common defective alleles associated with AAT deficiency (PI*S and PI*Z) but with a new mutation in heterozygosis. (ebscohost.com)
  • It references the study "Causal and Synthetic Association of Variants in the Serpina Gene Cluster With Alpha-Antitrypsin Serum Levels," by G. A. Thun et al. (ebscohost.com)
  • and as PSA complexed to alpha-1-antichymotrypsin, complexed PSA, with a molecular mass of 90 kDa. (avhandlingar.se)
  • There has been immense progress in the elucidation of the molecular and cellular pathophysiology of cystic fibrosis (CF) since the cloning of the CF gene in 1989 1 - 3 . (ersjournals.com)
  • 1 Many risk factors have been identified, but the molecular events responsible for the formation, growth, and rupture of cerebral saccular aneurysms remain unknown. (ajnr.org)
  • The serendipitous discovery that 18 F-fluorodeoxyglucose uptake reflects aberrant c-KIT signaling (and predicts response to imatinib therapy) in gastrointestinal stromal tumors has greatly simplified patient management ( 1 ) and, more generally, underscores the promise of molecular imaging in oncology. (aacrjournals.org)
  • Preclinical and early clinical testing of novel anticancer drugs can be significantly enabled by the inclusion of direct or surrogate biomarkers that correlate with pharmacologic effects ( 1, 2 ). (aacrjournals.org)
  • Recent studies have also implicated a role for PSA in the pathobiology of prostate cancer potentially through its ability to degrade the extracellular matrix and release or modify growth and survival factors such as IGF-1, TGF-beta and parathyroid hormone related peptide (PTHrP). (aacrjournals.org)
  • IJROBP 52(1):205-211, 2002) to try explaining the change in the fifty percent effective dose (ED50) for different field sizes. (diva-portal.org)
  • Recent studies from the Lee/Trojanowski group have begun to dissect out mechanisms whereby α-synuclein and tau can cross-seed the fibrillization of each other to form amyloid fibrils, and further research on this may help clarify the common co-occurrence of LBs and tangles in the same patient (1). (alzforum.org)
  • Then, for an individual to progress from normal age-appropriate cognitive function to a condition where the full palette of clinical symptoms is expressed, three key steps are envisioned: (1) an initiating injury, (2) a chronic neuroinflammatory response, and (3) a discontinuous cellular change of state involving most, if not all, of the cell types of the brain. (jneurosci.org)
  • Living-related Liver Transplantation from the View of the Donor: a 1-year Follow-up Survey. (jove.com)