Contribution of interleukin 1beta and KM loci to alopecia areata. (1/140)Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1beta single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata. (+info)
Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. (2/140)A type of hair loss closely resembling human alopecia areata has been described in C3H/HeJ mice. In order to test the assumed analogy with human alopecia areata, we investigated the efficacy of treatment with the contact allergen squaric acid dibutylester. In 12 C3H/HeJ mice with alopecia areata an allergic contact dermatitis was induced and elicited weekly on one side of the back by topical applications of squaric acid dibutylester. Overt hair regrowth was observed only on the treated side of the back in nine of 12 mice. Histopathologic examination revealed a change in the distribution of the inflammatory infiltrate from a dense perifollicular lymphocytic infiltrate around the mid and lower regions of hair follicles in untreated skin to a uniform presence in the upper dermis in treated skin. Immunohistomorphometric studies revealed that treatment with squaric acid dibutylester increased the CD4+/CD8+ ratio from approximately 1:2 in untreated alopecia areata to 1:1 in treated alopecia areata. Additional immunohistochemical investigations showed an aberrant expression of major histocompatibility complex class I, major histocompatibility complex class II and intercellular adhesion molecule 1 on keratinocytes of the mid and lower parts of hair follicles in untreated alopecia areata. In successfully treated skin ectopic major histocompatibility complex class I and II expression was clearly reduced, whereas intercellular adhesion molecule 1 expression showed only minor changes. In conclusion, alopecia areata-like hair loss in C3H/HeJ mice responded to treatment with the contact sensitizer squaric acid dibutylester analogous to human alopecia areata. Moreover, successful treatment changes the aberrant expression of major histocompatibility complex class I and II in a way similar to that observed in human alopecia areata. These observations support the concept that alopecia areata-like hair loss in C3H/HeJ mice can be utilized as an appropriate model for the study of human alopecia areata. (+info)
Role of cytotoxic T cells in chronic alopecia areata. (3/140)Cytokines play a role in alopecia areata. We used immunohistochemical and in situ hybridization studies to demonstrate the persistence of pro-inflammatory as well as apoptotic mechanisms in skin biopsies from patients with chronic alopecia areata. In situ hybridization allows the visualization of the distribution of immunocompetent cells in vivo. We studied skin biopsies from 11 untreated alopecia areata patients and two normal controls. In situ hybridization was performed on frozen sections using 35S-radio-labeled riboprobes, specific for IL-1beta, IL-2, IL-6, INFgamma, and granzyme B mRNA. Immunohistochemistry was carried out using an anti-IL-1beta monoclonal antibody, and a monoclonal antibody directed against the human Fas protein. We demonstrated the presence of cells labeled with IL-1beta, IL-6, INFgamma, and granzyme B antisense probes. Similarly, cells labeled with anti-IL-1beta were found in 10 of 11 cases. The labeled cells were located in the mononuclear peri- and intrafollicular infiltrate. Cells expressing granzyme B were found in close contact with the follicle. Fas positivity was demonstrated in four of four cases at the level of the cytoplasmic membrane of the hair follicle keratinocytes. These results, based on visualizing the labeled cells, demonstrate that pro-inflammatory cytokines are produced by the mononuclear cell infiltrate in close contact with follicles in alopecia areata. Furthermore, they demonstrate for the first time that apoptotic mechanisms involving granzyme B and Fas-Fas ligand pathways may play a major role in the persistence of chronic alopecia areata. (+info)
Heavy metal poisoning in glass worker characterised by severe. (4/140)The paper presents the clinical description of the masticatory organ and biochemical assessment of dental tissue in a patient employed in a glassworks for 20 years. During 12 years the patient has suffered baldness ("Alopecia areata") and atypical extensive and non-healing cutaneous lesions. Dental examination revealed changes typical of chronic poisoning by cadmium and bismuth compounds. (+info)
Practical management of hair loss. (5/140)OBJECTIVE: To describe an organized diagnostic approach for both nonscarring and scarring alopecias to help family physicians establish an accurate in-office diagnosis. To explain when ancillary laboratory workup is necessary to confirm the diagnosis. QUALITY OF EVIDENCE: Current diagnostic and therapeutic interventions for hair loss are based on randomized controlled studies, uncontrolled studies, and case series. MEDLINE was searched from January 1966 to December 1998 with the MeSH words alopecia, hair, and alopecia areata. Articles were selected on the basis of experimental design, with priority given to the most current large multicentre controlled studies. Overall global evidence for therapeutic intervention for hair loss is quite strong. MAIN MESSAGE: The most common forms of nonscarring alopecias are androgenic alopecia, telogen effluvium, and alopecia areata. Other disorders include trichotillomania, traction alopecia, tinea capitis, and hair shaft abnormalities. Scarring alopecia is caused by trauma, infections, discoid lupus erythematosus, or lichen planus. Key to establishing an accurate diagnosis is a detailed history, including medication use, systemic illnesses, endocrine dysfunction, hair-care practices, and family history. All hair-bearing sites should be examined. A 4-mm punch biopsy of the scalp is useful, particularly to diagnose scarring alopecias. Once a diagnosis has been established, specific therapy can be initiated. CONCLUSIONS: Diagnosis and management of hair loss is an interesting challenge for family physicians. An organized approach to recognizing characteristic differential features of hair loss disorders is key to diagnosis and management. (+info)
Treatment with an anti-CD44v10-specific antibody inhibits the onset of alopecia areata in C3H/HeJ mice. (6/140)A murine CD44v10-neutralizing antibody has been reported to impair delayed-type hypersensitivity reactions. Because alopecia areata is characterized by a delayed-type hypersensitivity-like T cell mediated immune response, we addressed the question whether an anti-CD44v10-antibody influences the onset of alopecia areata. Therefore, we used the C3H/HeJ mouse model with the induction of alopecia areata in unaffected mice by the grafting of lesional alopecia areata mouse skin. Six grafted mice were injected (intraperitoneally) with anti-CD44v10, six grafted mice with anti-CD44standard, and six with phosphate-buffered saline only. After 11 wk phosphate-buffered saline injected animals on average had developed alopecia areata on 36.8% of their body. The onset of hair loss was slightly delayed and its extent reduced to 17.2% of their body in anti-CD44standard-treated mice. By contrast, five of six anti-CD44v10-treated mice did not show any hair loss and one mouse developed alopecia areata on only 1% of the body. Immunohistochemical examination revealed a marked reduction of perifollicular CD8+ lymphocytes and, to a lesser degree, CD4+ cells as well as a decreased expression of major histocompatibility complex class I on hair follicle epithelium in anti-CD44v10-treated mice as compared with phosphate-buffered saline or anti-CD44 standard-treated mice. Our data show that anti-CD44v10 is able to inhibit the onset of alopecia areata in C3H/HeJ mice. This might be accomplished by an anti-CD44v10-triggered impairment of immune cell homing (e.g., CD8+ T cells), resulting in a decrease of their number in target tissues. (+info)
Interleukin-1 receptor antagonist allele 2 and familial alopecia areata. (7/140)Alopecia areata affects 1%-2% of the population and is hypothesized to be an autoimmune, organ specific T-cell mediated reaction directed against the human hair follicle. It is characterized by loss of hair in patches (alopecia areata) with progression in some individuals to total loss of scalp hair (alopecia totalis) or to loss of all scalp and body hair (alopecia universalis). The interleukin-1 receptor antagonist (IL-1RN) gene was found to be associated with more severe clinical outcome in several chronic inflammatory diseases, including alopecia areata. The IL-1RN*2 allele was found to be associated with alopecia areata severity in a British case-control study. In this paper, we analyzed alopecia areata probands in a family-based sample (n = 131 parent-offspring trios) to study the association between alleles of the IL-1RN and various phenotypes of alopecia areata. In considering all patients with any form of alopecia areata, no association was found with IL-1RN. IL-1RN*2 allele was not associated with alopecia totalis and alopecia universalis. A borderline association was observed between IL-1RN and patchy alopecia areata but it was not statistically significant (p =0.06). We also observed an association between IL1-RN*1 allele and patchy alopecia areata (p =0.045). (+info)
Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. (8/140)Alopecia areata is a tissue restricted autoimmune condition affecting the hair follicle, resulting in hair loss. The goal of this study was to test the hypothesis that the autoantigen of alopecia areata is melanocyte associated. Potential autoantigens were tested in the human scalp explant/Prkd(scid) CB-17 mouse transfer system. Scalp T cells from lesional (bald) alopecia areata scalp were cultured with antigen-presenting cells, and antigen, along with interleukin-2. The T cells were then injected into autologous lesional scalp grafts on SCID mice, and hair regrowth was measured. Hair follicle homogenate was used as an autoantigen control. T cells cultured with melanoma homogenate induced statistically significant reduction in hair growth (p <0.01 by ANOVA). HLA-A2-restricted melanocyte peptide epitopes were then tested with lesional scalp T cells from HLA-A2-positive alopecia areata patients. Melanocyte-peptide-activated T cells significantly reduced the number of hairs regrowing in two experiments with six patients (p <0.001 by ANOVA). Injected scalp grafts showed histologic and immunochemical changes of alopecia areata. The most consistent peptide autoantigens were the Gp100-derived G9-209 and G9-280 peptides, as well as MART-1 (27-35). Melanocyte peptide epitopes can function as autoantigens for alopecia areata. Multiple peptides were recognized, suggesting epitope spreading. (+info)
There are several types of alopecia areata, including:
1. Alopecia areata patchy - This is the most common form of the disease, where hair loss occurs in patches on the scalp or other parts of the body.
2. Alopecia totalis - Hair loss occurs over the entire scalp.
3. Alopecia universalis - Hair loss occurs over the entire body, including the scalp, eyebrows, and eyelashes.
4. Alopecia areata barbae - Hair loss occurs in the beard area.
5. Alopecia areata traction - Hair loss occurs due to pulling or tension on the hair shaft, often seen in children who pull their own hair.
The symptoms of alopecia areata may include:
1. Patchy hair loss
2. Thinning of hair
3. Redness and scalp inflammation
4. Itching or burning sensation on the scalp
5. Nail changes such as ridging, thinning, or pitting
Alopecia areata can be diagnosed through a physical examination and medical history. A skin scraping or biopsy may be performed to confirm the diagnosis.
Treatment for alopecia areata depends on the severity and location of hair loss, as well as the individual's overall health. Options may include:
1. Topical corticosteroids - Medicated creams or ointments applied directly to the affected area to reduce inflammation and promote hair growth.
2. Oral corticosteroids - Medications taken by mouth to reduce inflammation and suppress the immune system.
3. Anthralin - A medication that is applied to the skin to reduce inflammation and promote hair growth.
4. Immunotherapy - Injections or tablets that stimulate the immune system to attack cancer cells, but also can cause hair loss.
5. Wigs, hats, or other hairpieces - Used to cover up patchy hair loss.
6. Counseling or therapy - To help cope with the emotional impact of hair loss.
7. Hair transplantation - A surgical procedure that involves moving healthy hair follicles from one part of the scalp to another.
It is important to note that these treatments may not work for everyone and may have side effects. It's important to talk to a doctor or dermatologist to determine the best course of treatment for alopecia areata.
In addition to medical treatment, there are also some natural remedies that can help with alopecia areata such as:
1. Diet and nutrition - Eating a balanced diet rich in vitamins and minerals can promote hair growth.
2. Stress management - High stress levels have been linked to alopecia areata, so finding ways to manage stress, such as through exercise or meditation, may help.
3. Saw palmetto - A herb that has been shown to promote hair growth and slow down hair loss.
4. Fish oil - Omega-3 fatty acids found in fish oil have been shown to promote hair growth.
5. Coconut oil - Applying coconut oil to the scalp may help to stimulate hair growth.
6. Henna - A natural dye that can be used to color and strengthen hair, and may also help to promote hair growth.
7. Rosemary essential oil - May help to promote hair growth by increasing blood flow to the scalp.
8. Lavender essential oil - May help to reduce stress and promote relaxation, which can help with alopecia areata.
1. Alopecia areata: This is an autoimmune disorder that causes patchy hair loss on the scalp or body.
2. Androgenetic alopecia (male pattern baldness): This is a common condition in which men experience hair loss due to hormonal changes.
3. Telogen effluvium: This is a condition where there is an increase in the number of hair follicles that stop growing and enter the resting phase, leading to excessive hair shedding.
4. Alopecia totalis: This is a condition where all hair on the scalp is lost, including eyebrows and lashes.
5. Alopecia universalis: This is a condition where all body hair is lost.
Alopecia can be caused by a variety of factors, including genetics, hormonal imbalances, autoimmune disorders, and certain medications. Treatment options for alopecia depend on the underlying cause and may include medications, hair transplantation, or other therapies.
In medical literature, alopecia is often used as a term to describe the loss of hair in specific contexts, such as in the treatment of cancer patients or in the management of autoimmune disorders. It is also used to describe the side effects of certain medications, such as chemotherapy drugs that can cause hair loss.
Symptoms of trichotillomania may include:
* Recurrent urges to pull out one's own hair, often resulting in noticeable hair loss
* Repeatedly attempting to stop pulling out one's own hair but being unable to do so
* Feeling a sense of tension or discomfort before pulling out hair
* Feeling relief or pleasure after pulling out hair
* Avoidance of social situations due to feelings of shame or embarrassment about hair loss
Trichotillomania is considered a body-focused repetitive behavior (BFRB), which is a group of conditions characterized by recurrent, intrusive behaviors directed towards the body. Other BFRBs include trichophagia (hair eating disorder) and dermatillomania (skin picking disorder).
Treatment for trichotillomania typically involves a combination of medication and therapy, such as cognitive-behavioral therapy (CBT) or habit reversal training. Medications that may be used to treat trichotillomania include selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac) and sertraline (Zoloft), and antipsychotic medications, such as risperidone (Risperdal). Therapy may help individuals with trichotillomania identify and manage triggers for the behavior, and learn alternative coping strategies.
It is important to note that trichotillomania is a treatable condition, and with appropriate treatment, many individuals are able to manage their symptoms and achieve significant hair growth over time.
Examples of autoimmune diseases include:
1. Rheumatoid arthritis (RA): A condition where the immune system attacks the joints, leading to inflammation, pain, and joint damage.
2. Lupus: A condition where the immune system attacks various body parts, including the skin, joints, and organs.
3. Hashimoto's thyroiditis: A condition where the immune system attacks the thyroid gland, leading to hypothyroidism.
4. Multiple sclerosis (MS): A condition where the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to communication problems between the brain and the rest of the body.
5. Type 1 diabetes: A condition where the immune system attacks the insulin-producing cells in the pancreas, leading to high blood sugar levels.
6. Guillain-Barré syndrome: A condition where the immune system attacks the nerves, leading to muscle weakness and paralysis.
7. Psoriasis: A condition where the immune system attacks the skin, leading to red, scaly patches.
8. Crohn's disease and ulcerative colitis: Conditions where the immune system attacks the digestive tract, leading to inflammation and damage to the gut.
9. Sjögren's syndrome: A condition where the immune system attacks the glands that produce tears and saliva, leading to dry eyes and mouth.
10. Vasculitis: A condition where the immune system attacks the blood vessels, leading to inflammation and damage to the blood vessels.
The symptoms of autoimmune diseases vary depending on the specific disease and the organs or tissues affected. Common symptoms include fatigue, fever, joint pain, skin rashes, and swollen lymph nodes. Treatment for autoimmune diseases typically involves medication to suppress the immune system and reduce inflammation, as well as lifestyle changes such as dietary changes and stress management techniques.
National Alopecia Areata Foundation
Alopecia in animals
Mark G. Lebwohl
List of autoimmune diseases
Janus kinase inhibitor
Loose anagen syndrome
List of cutaneous conditions caused by mutations in keratins
Miloš M. Nikolić
List of skin conditions
Tissue-resident memory T cell
Justin Lee (activist)
Alopecia areata - About the Disease - Genetic and Rare Diseases Information Center
Alopecia Areata - Hair loss Causes & Living With It | NIAMS
Alopecia areata: MedlinePlus Genetics
Study Evaluates Alopecia Areata Features in Hispanic Population
National Alopecia Areata Foundation - | BiddingForGood
Alopecia areata - PubMed
Alopecia Areata - MeSH - NCBI
Alopecia areata - HEINE Optotechnik
Home - National Alopecia Areata Foundation | NAAF
Hair Loss Disease Alopecia Areata Befalls Scientist, Who Studies Disease And Eventually Cures It
Dithranol Cream as an Alopecia Areata Treatment
JCI Insight - Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata
Alopecia areata: Video, Anatomy, Definition & Function | Osmosis
Alopecia Areata Treatment At Home - Moore Unique Skin Care
Sono affetto da alopecia areata| ci sono possibilità di passare la malattia a mio figlio? | Calvizie.net
Alopecia is the term for bald. Welcome to the Alopecia Areata Marketplace - an online shop featuring the latest products for...
How to cure alopecia areata naturally? - hairmd
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National Alopecia Areata Foundation
BLOG - Alopecia areata - Ivantchev
Alopecia areata: A psychodermatological perspective. | J Cosmet Dermatol;21(6): 2318-2323, 2022 Jun. | MEDLINE
Alopecia Areata - Dr. Anki Reddy's
Alopecia Areata | Global Autoimmune Institute
Vapiano | Australia Alopecia Areata Foundation
Articles about Alopecia Areata | NIH MedlinePlus Magazine
cream for alopecia areata - sbhlifesciences.com
iRestore For Alopecia Areata (Updated 2021)
Types of alopecia areata2
- Alopecia universalis. (nih.gov)
- There is a progression to complete loss of body hair, a type of the disease called alopecia universalis. (nih.gov)
- Uncommonly, the hair loss involves the entire scalp (in which case the condition is known as alopecia totalis) or the whole body (alopecia universalis). (medlineplus.gov)
- Drawing from chart reviews, ICD codes, and documented physical exams, they retrospectively identified 197 Hispanic/Latinx patients diagnosed with AA at UCI between 2015 and 2022, including alopecia totalis and alopecia universalis. (medscape.com)
- However, alopecia areata can develop into two different forms of the disease as well if left untreated, called Alopecia totalis (where the entire scalp becomes bald) or Alopecia universalis (where all the hair on your entire body is lost). (mooreunique.com)
- Alopecia Universalis is a type of alopecia where the whole body gets affected. (hairmdindia.com)
- An unpredictable, transient, non-skin-scarring hair loss caused by destruction of hair follicles, which can eventually lead to the loss of all scalp hair (alopecia totalis) or all body hair (alopecia universalis). (autoimmuneinstitute.org)
- and alopecia universalis (100 percent scalp and 100 percent body hair loss). (nih.gov)
- 9. Efficacy of systemic minoxidil and tofacitinib combination in treatment-resistant alopecia universalis. (nih.gov)
- Patchy alopecia areata. (nih.gov)
- Alopecia" is a Latin term that means baldness, and "areata" refers to the patchy nature of the hair loss that is typically seen with this condition. (medlineplus.gov)
- Patchy alopecia areata affecting the scalp is the most common type. (nih.gov)
- Alopecia areata may occur as either a mild, chronic, patchy condition or as a severe, generalized hair loss. (medicalalgorithms.com)
- In alopecia areata, the target of the attack is the hair follicle, and the result is hair loss ranging from patchy baldness to complete loss of all scalp and body hair. (nih.gov)
- Scientists supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Cancer Institute (NCI) have identified genetic variations associated with the development of alopecia areata, a disease in which the body's immune system attacks the hair follicles, causing patchy, widespread or total hair loss. (nih.gov)
National Alopecia Areata Registry1
- The genetic material from alopecia areata patients was provided by the NIAMS-sponsored National Alopecia Areata Registry - a network of five centers that is registering, identifying and collecting information and blood samples. (nih.gov)
Forms of alopecia areata1
- Other rare forms of alopecia areata, which have different patterns of hair loss, have also been reported. (medlineplus.gov)
Cure for alopecia areata1
- There is no cure for alopecia areata, but there are treatments that help hair grow back more quickly. (nih.gov)
Therapies for alopecia areata2
Treat Alopecia areata1
- Above all, these home remedies help in hair growth and somewhat treat Alopecia areata. (hairmdindia.com)
Severe alopecia areata2
- Cite this: Study Evaluates Features of Alopecia Areata in the Hispanic/Latinx Population - Medscape - Dec 29, 2022. (medscape.com)
- Scientists have linked a number of genes to the disease, which suggests that genetics play a role in alopecia areata. (nih.gov)
- Of the 450,000 or so genetic markers studied, the comparison turned up about 150 that were represented differently in the people with alopecia areata, says Angela M. Christiano, Ph.D., Professor of Dermatology and Genetics and Development at Columbia University Medical Center, who led the study. (nih.gov)
- Dr. Christiano says the next steps are to gather and compare genetic information from more people with alopecia areata, and investigate shared genetics among all four diseases. (nih.gov)
- We conducted a literature search on PubMed and Google Scholar from January 1980 to May 2021 employing the search terms of alopecia areata , psychological factors , psychological impact, psychodermatology, and psychopathology . (bvsalud.org)
Developing other aut1
- People with alopecia areata have an increased risk of developing other autoimmune disorders, including vitiligo , systemic lupus erythematosus , atopic dermatitis , allergic asthma , and autoimmune thyroid diseases (such as Hashimoto's disease and Graves' disease ). (medlineplus.gov)
- alopecia areata is the second most common form after androgenetic alopecia (male-pattern baldness in men and female-pattern baldness in women). (medlineplus.gov)
- The method is applied with impressive results in many cases of universal or generalized Alopecia Areata, as well as in cases of Androgenetic or Diffuse Alopecia. (cosmeticdermamedicine.gr)
- At Cosmetic Derma Medicine, Autologous Hair Mesotherapy is applied with great success in many cases of hair loss and alopecia of various causes, especially in cases of androgenetic or diffuse alopecia, in both men and women. (cosmeticdermamedicine.gr)
- It is more common in people who already have androgenetic alopecia. (cosmeticdermamedicine.gr)
- This trial will evaluate the safety, tolerability and effect of ATI-502 Topical applied twice daily in 24 adult subjects (12 male, and 12 female) with androgenetic alopecia. (onlinehairclinic.com)
- U.S. patent number 9,895,301 covers the use of tofacitinib, a JAK inihibitor, for inducing hair growth and for treating hair loss disorders such as alopecia areata and androgenetic alopecia - otherwise known as male/female pattern hair loss. (onlinehairclinic.com)
- 7. Treatment of pediatric alopecia areata with anthralin: A retrospective study of 37 patients. (nih.gov)
- Alopecia areata (AA) is an autoimmune disease in which the immune system mistakenly attacks the hair follicles. (nih.gov)
- Alopecia areata is a disease that happens when the immune system attacks hair follicles and causes hair loss. (nih.gov)
- In alopecia areata, the immune system mistakenly attacks hair follicles, causing inflammation. (nih.gov)
- Alopecia areata is one of a large group of immune system diseases classified as autoimmune disorders. (medlineplus.gov)
- Immune system genes outside the HLA complex, such as several genes involved in inflammation, have also been associated with alopecia areata. (medlineplus.gov)
- When hair geneticist and dermatology professor Angela Christiano started losing her hair, she began to study the disease that was causing it: alopecia areata, which causes hair to fall out in round patches when the immune system attacks the hair follicles. (medicaldaily.com)
- Among Hispanic/Latinx patients with alopecia areata, the mean age at diagnosis was 33 years, 24% had concomitant atopy, and 18% had one or more coexisting autoimmune conditions, most commonly rheumatoid arthritis. (medscape.com)
- Nearly two-thirds of patients with alopecia were female (63%), and their mean age at diagnosis was 33 years. (medscape.com)
- A dermatoscope is becoming increasingly more important in the diagnosis of alopecia areata. (heine.com)
- Join A Support Group After an alopecia areata diagnosis, it is important to realize that you are not alone. (naaf.org)
- The diagnosis of Alopecia Areata is mainly clinical and its prognosis is uncertain. (cosmeticdermamedicine.gr)
- Mycosis fungoides is recognized at the time of diagnosis in approximately 15-30% of patients with alopecia mucinosa. (medscape.com)
- 3. Diagnosis of AA is in question or the pattern of hair loss is such that quantification of hair loss and assessment of regrowth is difficult, eg, patients with androgenic alopecia. (nih.gov)
- A recent study examined the epidemiology of alopecia areata (AA) in Black patients, wrote Mesinkovska and coauthors Celine Phong, a UCI medical student, and Amy J. McMichael, MD , professor of dermatology at Wake Forest University, Winston-Salem, N.C. "A similar unmet need exists to describe the characteristics of AA in Hispanic/Latinx (H/L) patients, the prevalent majority in California," they added. (medscape.com)
- It has also been applied with impressive results in many cases of alopecia pedis, even in cases of universal and generalized alopecia pedis, where usually the results of conservative treatments have poor results. (cosmeticdermamedicine.gr)
- This unexpected finding not only identifies potential targets for alopecia areata therapy, but suggests a shared disease mechanism that could help scientists study the immune pathology and develop treatments for all four diseases. (nih.gov)
- 4. Alopecia areata: evidence-based treatments. (nih.gov)
- Special guests and speakers will offer inspiration, professional caregivers will share medical information and advice to better understand and manage alopecia areata, and expert researchers will detail the latest in treatment development. (naaf.org)
- NAAF supports research to find a cure or acceptable treatment for alopecia areata, supports those with the disease, and educates the public about alopecia areata. (naaf.org)
- There is no evidence to suggest dithranol cream is an effective long-term alopecia areata treatment option. (belgraviacentre.com)
- For longer or more serious bouts of alopecia and hair loss, the most common treatment is steroids, which stimulate the follicles that are either obstructed or non-functional. (mooreunique.com)
- Some of the most common symptoms of Alopecia areata are as follows, and if you notice these, you should begin treatment as soon as possible with some of the home remedies. (mooreunique.com)
- This is just a brief summary on Alopecia Areata Treatment At Home. (mooreunique.com)
- The latest development in the treatment of Alopecia Areata is called Autologous Hair Mesotherapy. (cosmeticdermamedicine.gr)
- At Dr. Ankireddy's clinic we have a number of patients, who have benefitted from the treatment for Alopecia areata. (drankireddy.com)
- This treatment employs low-level lasers to treat alopecia, receding hairlines, thinning hair, balding, and stimulate hair growth in men and women alike. (auditoryverbaltraining.com)
- Aclaris' focus on market segments with no FDA-approved medications or where treatment gaps exist has resulted in the first FDA-approved treatment for raised seborrheic keratoses and several clinical programs to develop medications for the potential treatment of common warts, alopecia areata, and vitiligo. (onlinehairclinic.com)
- 7. No treatment for alopecia in the past 2 months prior to study enrollment. (nih.gov)
- 1. Childhood Alopecia Areata: An Overview of Treatment and Recent Patents. (nih.gov)
- 8. Treatment of alopecia areata with nonablative fractional laser combined with topical minoxidil. (nih.gov)
- 10. Current treatment of alopecia areata. (nih.gov)
- 11. Treatment of alopecia areata: An Australian expert consensus statement. (nih.gov)
- 13. Systemic steroids with or without 2% topical minoxidil in the treatment of alopecia areata. (nih.gov)
- 15. Topical immunotherapy in combination with anthralin in the treatment of refractory alopecia areata. (nih.gov)
- 19. Efficacy and Influence Factors of 308-nm Excimer Lamp with Minoxidil in the Treatment of Alopecia Areata. (nih.gov)
- Certain variations in HLA genes likely contribute to the inappropriate immune response targeting hair follicles that leads to alopecia areata. (medlineplus.gov)
- Alopecia areata is a type of hair loss that usually affects hair follicles. (osmosis.org)
- Alopecia areata is an autoimmune condition where your body attacks your hair follicles. (healthline.com)
- Alopecia mucinosa is a disease process defined histopathologically by mucin deposition in hair follicles and sebaceous glands, which undergo epithelial reticular degeneration. (medscape.com)
- When Do Symptoms of Alopecia areata Begin? (nih.gov)
- People with certain autoimmune diseases, such as psoriasis, thyroid disease, or vitiligo, are more likely to get alopecia areata, as are those with allergic conditions such as hay fever. (nih.gov)
- The autoimmune etiology of Alopecia Areata is supported by its coexistence with other autoimmune diseases such as vitiligo, Hashimoto's thyroiditis, Adison's disease, autoimmune polyendocrine syndromes, atopic dermatitis, Down's syndrome. (cosmeticdermamedicine.gr)
- What did surprise the researchers was that alopecia shared few, if any, genetic similarities with psoriasis and vitiligo, two autoimmune diseases of the skin, which they had suspected would be related to alopecia. (nih.gov)
- Alopecia areata affects men and women equally, and it can occur in people of any ethnic background. (medlineplus.gov)
- Alopecia areata tends to occur most often in adults 30 to 60 years of age and rarely young children. (drankireddy.com)
- Alopecia mucinosa can occur secondary to benign disease, including the inflammatory conditions lupus erythematosus , lichen simplex chronicus , and angiolymphoid hyperplasia . (medscape.com)
Type of alopecia2
- Alopecia mucinosa, often referred to as follicular mucinosis, was first reported by Pinkus in 1957. (medscape.com)
- The presenting sign of alopecia mucinosa is hair loss in hair-bearing areas. (medscape.com)
- Alopecia mucinosa represents various stages of follicular damage leading to hair loss. (medscape.com)
- Although the question of whether alopecia mucinosa is a transitional state evolving into mycosis fungoides is unresolved, it is proven that alopecia mucinosa may precede the development of mycosis fungoides by several years. (medscape.com)
- Thus, additional biopsy specimens and extremely close follow-up care are crucial in all variants of alopecia mucinosa. (medscape.com)
- Primary chronic alopecia mucinosa of older persons affects people older than 40 years. (medscape.com)
- The secondary alopecia mucinosa may be associated with either benign disease or malignant disease. (medscape.com)
- however, the concern exists that individuals exhibiting only alopecia mucinosa may also be at risk for subsequent development of lymphoma. (medscape.com)
- Alopecia mucinosa is a rare condition. (medscape.com)
- Although both sexes are affected by alopecia mucinosa, the disorder is more frequent in males than in females. (medscape.com)
Genetic variations associated1
- Some of the genetic variations associated with alopecia areata have been identified in people with other autoimmune disorders, which suggests that this group of diseases may share some genetic risk factors. (medlineplus.gov)
- It is possible that emotional stress or an illness can bring on alopecia areata in people who are at risk, but in most cases, there is no obvious trigger. (nih.gov)
- Significant correlations for anxiety, depression, quality of life and illness perception levels were found, indicating relationship between alopecia areata and emotional aspects. (bvsalud.org)
- Genetic studies in patients and mouse models have shown that alopecia areata is a complex, polygenic disease. (nih.gov)
- Alopecia areata is a common autoimmune disease, causing sudden hair loss on the scalp, face, and sometimes other areas of the body. (naaf.org)
- Christiano's alopecia areata developed decades ago - and in the 1990s she sent photographs of her bald spots to Pakistani researchers, asking them to collaborate with her on a study about the disease. (medicaldaily.com)
- Common γ chain cytokines and interferon-γ that use the JAK/STAT pathway to induce biological responses have been implicated in the pathogenesis of alopecia areata (AA), a T cell-mediated autoimmune disease of the hair follicle. (jci.org)
- To evaluate a patient with alopecia areata for risk factors associated development of severe disease. (medicalalgorithms.com)
- The autoimmune disease of Alopecia Areata is characterized by the loss of some or all of the hair, most commonly from the scalp. (cosmeticdermamedicine.gr)
- Alopecia Areata is a pathological condition that affects 1-2% of the population, regardless of gender, while the disease is most common in children and adolescents. (cosmeticdermamedicine.gr)
- For nearly 40 years The National Alopecia Areata Foundation has been the leader of support and research of this autoimmune disease. (measuretwice.com)
- Although the exact cause of the disease is unknown, at least 20% have relatives with alopecia, which implies that there is a genetic predisposition. (autoimmuneinstitute.org)
- Alopecia Areata (AA) is an autoimmune dermatological disease that could be influenced by psychological factors as part of the pathophysiology of the illness. (bvsalud.org)
- Dr. Christiano studies a hair loss disease called alopecia areata. (medlineplus.gov)
- Alopecia areata is a difficult disease to cope with, but there are ways for people to feel better. (medlineplus.gov)
- A national registry for alopecia areata, a disease whose hallmark is unexplained hair loss, has been established by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health (NIH). (nih.gov)
- Alopecia areata is an autoimmune disease, one in which the body's natural defense system attacks healthy cells. (nih.gov)
- The genome-wide association study, the first of its kind for alopecia areata, compared genetic material from 1,054 people with alopecia areata to that of 3,278 people without the disease, looking for genomic regions where people with the disease differed from controls. (nih.gov)
- Even more surprising was that alopecia shared similarities with three seemingly unrelated autoimmune diseases with completely different targets: rheumatoid arthritis, type 1 diabetes and celiac disease. (nih.gov)
- One clue to a shared disease mechanism came from a gene called ULBP3 , which was upregulated in scalp biopsies of the alopecia areata patients. (nih.gov)
- Alopecia areata primarily affects hair, but in some cases, there are nail changes as well. (nih.gov)
- Alopecia Areata is a common autoimmune disorder that often results in unpredictable hair loss. (drankireddy.com)
- Although the exact cause of AA is unknown, roughly 20% of affected people have a family member with alopecia, suggesting that genetic factors may contribute to the development of the condition. (nih.gov)
- In most people with alopecia areata, hair falls out in small, round patches, leaving coin-sized areas of bare skin. (medlineplus.gov)
- Alopecia areata affects people of all ages, although it most commonly appears in adolescence or early adulthood. (medlineplus.gov)
- Alopecia areata affects 1 in every 500 to 1,000 people in the United States. (medlineplus.gov)
- Similarly, people with those autoimmune disorders have an increased risk of developing alopecia areata. (medlineplus.gov)
- In many cases, it is unknown what triggers hair loss in people with alopecia areata. (medlineplus.gov)
- People with alopecia areata are also more likely to have family members with other autoimmune disorders. (medlineplus.gov)
- In a new study published in Nature , Christiano tested a drug known as a JAK inhibitor, which is already being used for other conditions, and successfully stopped hair loss in people with alopecia areata. (medicaldaily.com)
- For this reason, home remedies are often turned to by people who suffer from Alopecia areata. (mooreunique.com)
- Home remedies are usually turned to by people who are dealing with Alopecia areata. (mooreunique.com)
- Statistical research shows that on average 20% of people with alopecia areata report having at least one other blood relative with the condition (Muller 1963, De Weert 1984, Friedman 1981, Shellow 1992). (calvizie.net)
- About more than 4.6 million people in India struggle with alopecia areata. (hairmdindia.com)
- Some people with APECED have a type of hair loss called alopecia areata (AA). (nih.gov)
- Because drugs that target the pathway are in development for these other diseases, Dr. Christiano believes these same drugs might be effective against alopecia areata, the most common among all autoimmune diseases. (nih.gov)
- Alopecia is the term for bald. (peggyknight.com)
- While hair can be lost from any part of the body, alopecia areata usually affects the head and face. (nih.gov)
- NAAF's Youth Mentor Program connects children living with alopecia areata to dedicated young adult mentors to formulate lasting bonds while providing support and guidance on dealing with the day-to-day challenges stemming from alopecia areata. (naaf.org)
- Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. (nih.gov)
Round or oval2
- Alopecia areata typically begins with sudden loss of round or oval patches of hair on the scalp, but any part of the body may be affected, such as the beard area in men, or the eyebrows or eyelashes. (nih.gov)
- In this case, the alopecia is usually limited to a desquamating plaque usually on the scalp in a round or oval shape. (cosmeticdermamedicine.gr)
- Although there are many different medical conditions that can result in hair loss, one of the most common afflictions is called Alopecia areata. (mooreunique.com)
- Below are the most common Homeopathic medicines for Alopecia areata from our case archives, that have shown very encouraging results. (drankireddy.com)
- Sometimes, psychological or situational factors can cause small flare-ups of alopecia and hair loss, but they can sometimes automatically regress and the hair grows back. (mooreunique.com)
- Does alopecia areata (AA) affect all races and ethnic groups equally? (naaf.org)