Phase II trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix. (1/646)PURPOSE: Both paclitaxel and cisplatin have moderate activity in patients with metastatic or recurrent cancer of the cervix, and the combination of these two agents has shown activity and possible synergism in a variety of solid tumors. We administered this combination to patients with metastatic or recurrent cervical cancer to evaluate its activity. PATIENTS AND METHODS: Thirty-four consecutive patients were treated on an outpatient basis with paclitaxel 175 mg/m2 administered intravenously over a 3-hour period followed by cisplatin 75 mg/m2 administered intravenously with granulocyte colony-stimulating factor support. The chemotherapy was administered every 3 weeks for a maximum of six courses. RESULTS: Sixteen patients (47%; 95% confidence interval, 30% to 65%) achieved an objective response, including five complete responses and 11 partial responses. Responses occurred in 28% of patients with disease within the radiation field only and in 57% of patients with disease involving other sites. The median duration of response was 5.5 months, and the median times to progression and survival for all patients were 5 and 9 months, respectively. Grade 3 or 4 toxicities included anemia in 18% of patients and granulocytopenia in 15% of patients. Fifty-three percent of patients developed some degree of neurotoxicity; 21% of cases were grade 2 or worse. CONCLUSION: The combination of paclitaxel with cisplatin seems relatively well tolerated and moderately active in patients with metastatic or recurrent cervical cancer. The significant incidence of neurotoxicity is of concern, and alternative methods of administration of the two agents could be evaluated. Then, further study of this combination, alone or with the addition of other active agents, is warranted. (+info)
Phase I-II study of gemcitabine and carboplatin in stage IIIB-IV non-small-cell lung cancer. (2/646)PURPOSE: Platinum-based chemotherapy currently represents standard treatment for advanced non-small-cell lung cancer. Gemcitabine is one of the most interesting agents currently in use in advanced non-small-cell lung cancer, and high response rates have been reported when it is administered in combination with cisplatin. The aim of the present study was to evaluate the combination of gemcitabine and carboplatin in a phase I-II study. PATIENTS AND METHODS: Chemotherapy-naive patients with stage IIIB-IV non-small-cell lung cancer received carboplatin at area under the concentration-time curve (AUC) 5 mg/mL/min and gemcitabine at an initial dose of 800 mg/m2, subsequently escalated by 100 mg/m2 per step. Gemcitabine was administered on days 1 and 8 and carboplatin on day 8 of the 28-day cycle. Dose escalation proceeded up to dose-limiting toxicity (DLT), which was defined as grade 4 neutropenia or thrombocytopenia or grade 3 nonhematologic toxicity. RESULTS: Neutropenia was DLT, inasmuch as it occurred in three of five patients receiving gemcitabine 1,200 mg/m2. Nonhematologic toxicities were mild. Gemcitabine 1,100 mg/m2 plus carboplatin AUC 5 was recommended for phase II studies. An objective response was observed in 13 (50%) of 26 patients, including four complete responses (15%) and nine partial responses (35%). Median duration of response was 13 months (range, 3 to 23 months). Median overall survival was 16 months (range, 3 to 26 months). CONCLUSION: The combination of gemcitabine and carboplatin is well tolerated and active. Neutropenia was DLT. The observed activity matches that observable in cisplatin-gemcitabine studies, whereas duration of response and survival are even higher. A phase II trial is under way. (+info)
Longevity, stress response, and cancer in aging telomerase-deficient mice. (3/646)Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR-/- mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism. (+info)
Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group. (4/646)Leukemic patients receiving marrow from HLA-identical sibling donors were randomized to treatment with either busulfan 16 mg/kg (n = 88) or total body irradiation ([TBI] n = 79) in addition to cyclophosphamide 120 mg/kg. The patients were observed for a period of 5 to 9 years. Busulfan-treated patients had an increased risk of veno-occlusive disease (VOD) of the liver (12% v 1%, P =.01) and hemorrhagic cystitis (32% v 10%, P =.003). Acute graft-versus-host disease (GVHD) was similar in the two groups, but the 7-year cumulative incidence of chronic GVHD was 59% in the busulfan-treated group versus 47% in the TBI group (P =.05). Death from GVHD was more common in the busulfan group (22% v 3%, P <.001). Obstructive bronchiolitis occurred in 26% of the busulfan patients but in only 5% of the TBI patients (P <.01). Complete alopecia developed in 8 busulfan patients and partial alopecia in 17, versus five with partial alopecia in the TBI group (P <.001). Cataracts occurred in 5 busulfan-treated patients and 16 TBI patients (P =.02). The incidence of relapse after 7 years was 29% in both groups. Seven-year transplant-related mortality (TRM) in patients with early disease was 21% in the busulfan group and 12% in the TBI group. In patients with more advanced disease, the corresponding figures were 64% and 22%, respectively (P =.004). Leukemia-free survival (LFS) in patients with early disease was 68% in busulfan-treated patients and 66% in TBI patients. However, 7-year LFS in patients with more advanced disease was 17% in the busulfan group versus 49% in the TBI group (P <.01). In patients with chronic myeloid leukemia (CML) in first chronic phase, 7-year LFS was 72% and 83% in the two groups, respectively. (+info)
Clomipramine-induced urinary retention in a cat. (5/646)A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). The cat developed urinary retention within 2 days. Clomipramine was discontinued. Clinical signs resolved over the next 7 days. The urinary retention was attributed to the anticholinergic effects of clomipramine. (+info)
Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias. (6/646)Recently, we showed that atrichia with papular lesions (APL), a rare inherited form of alopecia, is transmitted as an autosomal recessive trait in a large inbred kindred of Israeli-Arab origin. Furthermore, we mapped the APL locus to a 5-cM region of chromosome 8p12 in this family. The human "hairless" gene is a candidate target gene for the disease mutation because it maps to the APL locus and because it was recently found to be mutated in a related but clinically distinct form of alopecia known as "alopecia universalis" or "congenital alopecia." In the present study, the coding sequence of the hairless gene was compared by reverse transcription-PCR in fibroblast cell lines derived from an affected patient and an unrelated individual. We identified a single-base deletion (3434delC) in the hairless gene that cosegregated with the disease phenotype in the family. This deletion is predicted to cause a frameshift mutation in the highly conserved C-terminal part of the hairless protein, a region putatively involved in the transcription factor activity of the hairless gene product. The present results are indicative of phenotypic heterogeneity in inherited atrichias caused by mutations in the hairless gene, suggesting different roles for the regions mutated in APL and in other forms of congenital atrichia during hair development. (+info)
Medical treatments for balding in men. (7/646)Two drugs are available for the treatment of balding in men. Minoxidil, a topical product, is available without a prescription in two strengths. Finasteride is a prescription drug taken orally once daily. Both agents are modestly effective in maintaining (and sometimes regrowing) hair that is lost as a result of androgenic alopecia. The vertex of the scalp is the area that is most likely to respond to treatment, with little or no hair regrowth occurring on the anterior scalp or at the hairline. Side effects of these medications are minimal, making them suitable treatments for this benign but psychologically disruptive condition. (+info)
Insulin gene polymorphism and premature male pattern baldness in the general population. (8/646)Insulin is found in hair follicles and may play a role in the regulation of androgen metabolism and the hair growth cycle, which are relevant to the loss of scalp hair known as male pattern baldness. An excess of dihydrotestosterone on balding scalp indicates that the condition is androgen dependent. Premature male pattern baldness may be the male phenotype of familial polycystic ovary syndrome, a condition characterized by high levels of androgens and insulin that has been linked to insulin gene polymorphism. Therefore, we studied possible associations between relevant insulin gene polymorphisms and premature male pattern baldness in the general community. We examined the distribution of three dimorphic restriction fragment length polymorphisms: HphI, PstI and FokI in cases consisting of 56 men aged 18-30 years with significant baldness, and in 107 control men aged 50 years or more with no indication of baldness. No significant differences between cases and controls in allele, genotype or haplotype frequencies were identified. We conclude that, in the general population, the insulin gene is not associated with premature male pattern baldness. (+info)
1. Alopecia areata: This is an autoimmune disorder that causes patchy hair loss on the scalp or body.
2. Androgenetic alopecia (male pattern baldness): This is a common condition in which men experience hair loss due to hormonal changes.
3. Telogen effluvium: This is a condition where there is an increase in the number of hair follicles that stop growing and enter the resting phase, leading to excessive hair shedding.
4. Alopecia totalis: This is a condition where all hair on the scalp is lost, including eyebrows and lashes.
5. Alopecia universalis: This is a condition where all body hair is lost.
Alopecia can be caused by a variety of factors, including genetics, hormonal imbalances, autoimmune disorders, and certain medications. Treatment options for alopecia depend on the underlying cause and may include medications, hair transplantation, or other therapies.
In medical literature, alopecia is often used as a term to describe the loss of hair in specific contexts, such as in the treatment of cancer patients or in the management of autoimmune disorders. It is also used to describe the side effects of certain medications, such as chemotherapy drugs that can cause hair loss.
There are several types of alopecia areata, including:
1. Alopecia areata patchy - This is the most common form of the disease, where hair loss occurs in patches on the scalp or other parts of the body.
2. Alopecia totalis - Hair loss occurs over the entire scalp.
3. Alopecia universalis - Hair loss occurs over the entire body, including the scalp, eyebrows, and eyelashes.
4. Alopecia areata barbae - Hair loss occurs in the beard area.
5. Alopecia areata traction - Hair loss occurs due to pulling or tension on the hair shaft, often seen in children who pull their own hair.
The symptoms of alopecia areata may include:
1. Patchy hair loss
2. Thinning of hair
3. Redness and scalp inflammation
4. Itching or burning sensation on the scalp
5. Nail changes such as ridging, thinning, or pitting
Alopecia areata can be diagnosed through a physical examination and medical history. A skin scraping or biopsy may be performed to confirm the diagnosis.
Treatment for alopecia areata depends on the severity and location of hair loss, as well as the individual's overall health. Options may include:
1. Topical corticosteroids - Medicated creams or ointments applied directly to the affected area to reduce inflammation and promote hair growth.
2. Oral corticosteroids - Medications taken by mouth to reduce inflammation and suppress the immune system.
3. Anthralin - A medication that is applied to the skin to reduce inflammation and promote hair growth.
4. Immunotherapy - Injections or tablets that stimulate the immune system to attack cancer cells, but also can cause hair loss.
5. Wigs, hats, or other hairpieces - Used to cover up patchy hair loss.
6. Counseling or therapy - To help cope with the emotional impact of hair loss.
7. Hair transplantation - A surgical procedure that involves moving healthy hair follicles from one part of the scalp to another.
It is important to note that these treatments may not work for everyone and may have side effects. It's important to talk to a doctor or dermatologist to determine the best course of treatment for alopecia areata.
In addition to medical treatment, there are also some natural remedies that can help with alopecia areata such as:
1. Diet and nutrition - Eating a balanced diet rich in vitamins and minerals can promote hair growth.
2. Stress management - High stress levels have been linked to alopecia areata, so finding ways to manage stress, such as through exercise or meditation, may help.
3. Saw palmetto - A herb that has been shown to promote hair growth and slow down hair loss.
4. Fish oil - Omega-3 fatty acids found in fish oil have been shown to promote hair growth.
5. Coconut oil - Applying coconut oil to the scalp may help to stimulate hair growth.
6. Henna - A natural dye that can be used to color and strengthen hair, and may also help to promote hair growth.
7. Rosemary essential oil - May help to promote hair growth by increasing blood flow to the scalp.
8. Lavender essential oil - May help to reduce stress and promote relaxation, which can help with alopecia areata.
Some common types of scalp dermatoses include:
1. Dandruff: A chronic condition characterized by flaky, white scales on the scalp.
2. Psoriasis: An autoimmune disorder that causes red, itchy patches on the scalp.
3. Eczema: A chronic skin condition characterized by dryness, itching, and inflammation.
4. Contact dermatitis: A skin reaction caused by exposure to an allergen or irritant, leading to redness, itching, and blisters.
5. Seborrheic dermatitis: A condition characterized by a yellowish, oily discharge on the scalp.
6. Pityriasis simplex: A condition characterized by small, scaling patches on the scalp.
7. Tinea capitis: A fungal infection of the scalp that can cause itching, redness, and scaling.
8. Cradle cap (infantile seborrheic dermatitis): A condition that affects newborn babies, causing yellowish, oily scales on the scalp.
Scalp dermatoses can be diagnosed through a physical examination of the scalp and may require further testing such as blood work or skin scrapings to rule out other conditions. Treatment options vary depending on the specific condition and can include medicated shampoos, topical creams or ointments, antifungal medications, and lifestyle changes such as reducing stress and using gentle hair care products.
In summary, scalp dermatoses are conditions that affect the skin on the scalp, and can cause a range of symptoms such as itching, redness, scaling, and inflammation. Common types of scalp dermatoses include dandruff, psoriasis, eczema, contact dermatitis, pityriasis simplex, tinea capitis, and cradle cap. Diagnosis is through physical examination and may require further testing, while treatment options vary depending on the specific condition.
If left untreated, folliculitis can lead to more serious infections such as boils or abscesses, which may require surgical drainage. It is also possible for folliculitis to cause scarring and permanent hair loss if the inflammation damages the hair follicle.
While anyone can develop folliculitis, it is more common in people with oily skin or those who wear tight clothing or heavy makeup that can clog pores and irritate the skin. Additionally, certain medical conditions such as diabetes, HIV/AIDS, and cancer can increase the risk of developing folliculitis.
Folliculitis is usually diagnosed through a physical examination and may require a biopsy to rule out other skin conditions. Treatment options for folliculitis depend on the severity and cause of the condition, but may include antibiotics, topical creams, or oral medications. It is important to seek medical attention if symptoms persist or worsen over time, as early treatment can help prevent complications and improve outcomes.
Tinea capitis, also known as ringworm of the scalp, is a common fungal infection that affects the skin and hair on the head. It is caused by a group of fungi called dermatophytes, which thrive in warm, moist environments. The infection typically appears as round, scaly patches on the scalp, with a clear border and a raised, rough texture.
The symptoms of tinea capitis can include:
* Scaly, itchy patches on the scalp
* Hair loss or thinning in the affected areas
* Redness and swelling around the patches
* Flaky skin that may look like dandruff
* Itching, which can be intense and uncomfortable
Tinea capitis is usually diagnosed by a dermatologist or primary care physician based on the appearance of the lesions and a physical examination. A scalp scraping or skin biopsy may also be performed to confirm the diagnosis.
Treatment for tinea capitis typically involves antifungal medications, such as griseofulvin, terbinafine, or itraconazole, which are applied directly to the affected areas of the scalp. In severe cases, oral antifungal medications may be prescribed.
In addition to medical treatment, there are several home remedies that can help relieve the symptoms of tinea capitis, such as:
* Applying an over-the-counter antifungal cream or powder to the affected areas
* Using a medicated shampoo containing ketoconazole or selenium sulfide
* Keeping the scalp clean and dry, and avoiding sharing hair accessories or using unwashed towels
* Wearing loose, breathable clothing to reduce sweating and prevent further fungal growth.
It's important to note that tinea capitis can be contagious and can spread to other people through close contact with an infected individual. Therefore, it's important to take steps to prevent the spread of the infection, such as avoiding sharing personal items and keeping the affected areas clean and dry.
Symptoms of trichotillomania may include:
* Recurrent urges to pull out one's own hair, often resulting in noticeable hair loss
* Repeatedly attempting to stop pulling out one's own hair but being unable to do so
* Feeling a sense of tension or discomfort before pulling out hair
* Feeling relief or pleasure after pulling out hair
* Avoidance of social situations due to feelings of shame or embarrassment about hair loss
Trichotillomania is considered a body-focused repetitive behavior (BFRB), which is a group of conditions characterized by recurrent, intrusive behaviors directed towards the body. Other BFRBs include trichophagia (hair eating disorder) and dermatillomania (skin picking disorder).
Treatment for trichotillomania typically involves a combination of medication and therapy, such as cognitive-behavioral therapy (CBT) or habit reversal training. Medications that may be used to treat trichotillomania include selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac) and sertraline (Zoloft), and antipsychotic medications, such as risperidone (Risperdal). Therapy may help individuals with trichotillomania identify and manage triggers for the behavior, and learn alternative coping strategies.
It is important to note that trichotillomania is a treatable condition, and with appropriate treatment, many individuals are able to manage their symptoms and achieve significant hair growth over time.
Cicatrix is a term used to describe the scar tissue that forms after an injury or surgery. It is made up of collagen fibers and other cells, and its formation is a natural part of the healing process. The cicatrix can be either hypertrophic (raised) or atrophic (depressed), depending on the severity of the original wound.
The cicatrix serves several important functions in the healing process, including:
1. Protection: The cicatrix helps to protect the underlying tissue from further injury and provides a barrier against infection.
2. Strength: The collagen fibers in the cicatrix give the scar tissue strength and flexibility, allowing it to withstand stress and strain.
3. Support: The cicatrix provides support to the surrounding tissue, helping to maintain the shape of the affected area.
4. Cosmetic appearance: The appearance of the cicatrix can affect the cosmetic outcome of a wound or surgical incision. Hypertrophic scars are typically red and raised, while atrophic scars are depressed and may be less noticeable.
While the formation of cicatrix is a normal part of the healing process, there are some conditions that can affect its development or appearance. For example, keloid scars are raised, thick scars that can form as a result of an overactive immune response to injury. Acne scars can also be difficult to treat and may leave a lasting impression on the skin.
In conclusion, cicatrix is an important part of the healing process after an injury or surgery. It provides protection, strength, support, and can affect the cosmetic appearance of the affected area. Understanding the formation and functions of cicatrix can help medical professionals to better manage wound healing and improve patient outcomes.
Photophobia can be caused by various factors, including:
1. Eye conditions like cataracts, glaucoma, or retinal detachment
2. Medications like tranquilizers, antidepressants, or antihistamines
3. Head injuries or brain disorders
4. Chronic diseases such as multiple sclerosis or migraines
5. Vitamin deficiencies like vitamin A or B12
6. Exposure to certain chemicals or toxins
Symptoms of photophobia may include:
1. Discomfort or pain in the eyes when exposed to light
2. Blurred vision or sensitivity to glare
3. Difficulty seeing in bright environments
4. Headaches or migraines triggered by light exposure
5. Nausea or dizziness
6. Sensitivity to light that worsens over time
Diagnosis of photophobia typically involves a comprehensive eye exam to rule out any underlying eye conditions. Medical history and lifestyle factors may also be considered to identify potential causes. Treatment options for photophobia depend on the underlying cause, but may include:
1. Eyewear with tinted lenses or UV protection
2. Medications to reduce light sensitivity or alleviate symptoms
3. Adjustments to lighting environments
4. Lifestyle changes like avoiding bright lights, wearing sunglasses, or using a brimmed hat
5. Treatment of underlying conditions or diseases causing photophobia.
In summary, photophobia is a condition characterized by an excessive sensitivity to light, which can cause various discomforts and symptoms. Identifying the underlying cause through comprehensive diagnosis and implementing appropriate treatment options can help alleviate these symptoms and improve quality of life for individuals experiencing photophobia.
There are several forms of lichen planus, including:
* Oral lichen planus: affecting the mucous membranes inside the mouth
* Cutaneous lichen planus: affecting the skin
* Lichen planus pigmentosus: causing hyperpigmentation of the skin
* Lichen planus hypertrophicus: causing thickening and darkening of the skin.
Symptoms of lichen planus may include:
* Itching, burning sensations on the affected area
* Redness, inflammation, or swelling
* Thickening and darkening of the skin in advanced cases
* Blisters or sores that may ooze fluid
There is no cure for lichen planus, but treatment options are available to manage symptoms and prevent flare-ups. These may include:
* Topical corticosteroids to reduce inflammation and itching
* Oral antihistamines or immunosuppressive drugs to reduce itching and inflammation
* Phototherapy with UVB or PUVA to reduce inflammation and promote skin healing
* Systemic corticosteroids for severe cases that do not respond to other treatments.
It is important to seek medical advice if you experience any of the symptoms of lichen planus, as it can be difficult to diagnose and may resemble other skin conditions such as eczema or psoriasis. A dermatologist can perform a physical examination, take a skin scraping or biopsy, and review your medical history to make an accurate diagnosis and recommend appropriate treatment.
There are several types of hypotrichosis, including:
1. Congenital hypotrichosis: This type is present at birth and is caused by genetic mutations.
2. Acquired hypotrichosis: This type can develop later in life due to various factors such as hormonal imbalances, nutritional deficiencies, or certain medical conditions like thyroid disorders or anemia.
3. Localized hypotrichosis: This type affects only a specific area of the body, such as the scalp or eyebrows.
4. Generalized hypotrichosis: This type affects the entire body.
Hypotrichosis can have a significant impact on an individual's self-esteem and quality of life, especially if it results in noticeable hair loss or thinning. Treatment options for hypotrichosis include medications such as minoxidil (Rogaine) and finasteride (Propecia), as well as non-medical treatments like hair transplantation and low-level laser therapy (LLLT). In some cases, hypotrichosis may be a sign of an underlying medical condition, so it is important to consult with a healthcare professional for proper diagnosis and treatment.
Symptoms of ichthyosis can include:
* Thickened, scaly skin on the arms, legs, back, and chest
* Redness and itching
* Cracking and splitting of the skin
* Increased risk of infection
* Respiratory problems
Treatment for ichthyosis typically involves the use of topical creams and ointments to help soften and hydrate the skin, as well as oral medications to reduce inflammation and itching. In severe cases, phototherapy or systemic corticosteroids may be necessary.
In addition to these medical treatments, there are also several home remedies and lifestyle modifications that can help manage the symptoms of ichthyosis. These include:
* Moisturizing regularly with a fragrance-free moisturizer
* Avoiding harsh soaps and cleansers
* Using lukewarm water when showering or bathing
* Applying cool compresses to the skin to reduce redness and inflammation
* Wearing loose, breathable clothing to avoid irritating the skin
* Protecting the skin from extreme temperatures and environmental stressors.
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alopecia Archives - Humanitas.net
- Spanning genetic hair loss to the autoimmune conditions Alopecia Areata, Totalis and Universalis (the conditions which cause your hair to fall out, so you were right about this). (belgraviacentre.com)
- Joli Caméléon is looking for 1-3 Models with Alopecia Totalis or Universalis, or Areata with very little current hair growth, for an industry event in Charlotte, Sat 10 - Mon 12 September. (alopeciaworld.com)
- The drug - part of a class of medicines known as JAK inhibitors - is the first approved treatment for alopecia areata. (alopeciaworld.com)
- The presentation highlights THRIVE-AA2 study results evaluating the oral investigational medicine deuruxolitinib in adult patients with moderate to severe alopecia areata, an autoimmune disorder that results in patchy or complete scalp hair loss. (khon2.com)
- Alopecia Areata - It is a hair loss condition that causes discrete round bald patches appearing on different parts of the scalp with the remaining hairs on the head being entirely unaffected. (olivaclinic.com)
- They discovered it was caused by alopecia areata. (hairclub.com)
- As September was Alopecia awareness month I think it's important that we dive even deeper into the world of hairloss, pass Adrogenetic Alopecia and Alopecia Areata, two causes of hair loss that I discussed in my last blog . (salontoday.com)
- These data are highly encouraging and support the potential of deuruxolitnib to regrow hair on the scalp, eyebrows and eyelashes in patients with alopecia areata, and in many cases with a rapid onset of effect," stated Dr. King. (kark.com)
- The autoimmune disease of Alopecia Areata is characterized by the loss of some or all of the hair, most commonly from the scalp. (cosmeticdermamedicine.gr)
- Alopecia Areata is a pathological condition that affects 1-2% of the population, regardless of gender, while the disease is most common in children and adolescents. (cosmeticdermamedicine.gr)
- The diagnosis of Alopecia Areata is mainly clinical and its prognosis is uncertain. (cosmeticdermamedicine.gr)
- The latest development in the treatment of Alopecia Areata is called Autologous Hair Mesotherapy. (cosmeticdermamedicine.gr)
- The method is applied with impressive results in many cases of universal or generalized Alopecia Areata, as well as in cases of Androgenetic or Diffuse Alopecia. (cosmeticdermamedicine.gr)
- In selected cases of localized Alopecia Areata with stability in the progression of hair loss for more than one year, hair loss can be treated with the FUE Hair Transplantation method. (cosmeticdermamedicine.gr)
- What causes the appearance of Alopecia Areata? (cosmeticdermamedicine.gr)
- The autoimmune etiology of Alopecia Areata is supported by its coexistence with other autoimmune diseases such as vitiligo, Hashimoto's thyroiditis, Adison's disease, autoimmune polyendocrine syndromes, atopic dermatitis, Down's syndrome. (cosmeticdermamedicine.gr)
- What are the types of Alopecia Areata? (cosmeticdermamedicine.gr)
- Circumscribed Alopecia Areata. (cosmeticdermamedicine.gr)
- Persistent patchy alopecia areata. (cosmeticdermamedicine.gr)
- Diffuse alopecia areata. (cosmeticdermamedicine.gr)
- Given the interest in the emerging and evolving coronavirus (COVID-19) pandemic and the questions regarding how this will impact patients with alopecia (including alopecia areata and other alopecias) who are treated with systemic immunomodulating medication, we have created a secure, online, de-identified Personal Health Identifier (PHI)-free reporting registry. (covidderm.org)
- Alopecia areata is a common autoimmune disorder that often results in unpredictable hair loss. (myacare.com)
- While there is no cure for alopecia areata, there are some forms of treatment that can be suggested by doctors to help hair re-grow more quickly. (myacare.com)
- The most common form of alopecia areata treatment is the use of corticosteroids, powerful anti-inflammatory drugs that can suppress the immune system. (myacare.com)
- There are a number of different types of alopecia, the main two being alopecia areata, and androgenetic alopecia. (homeofherbs.ie)
- Alopecia areata is an auto-immune condition and usually starts with small patches appearing on the scalp where some hair has fallen out. (homeofherbs.ie)
- This is particularly so in the case of Alopecia areata, but both of these imbalances can be caused or exacerbated by the level of stress we are experiencing. (homeofherbs.ie)
- Dr. Christiano studies a hair loss disease called alopecia areata. (medlineplus.gov)
- Alopecia areata is a difficult disease to cope with, but there are ways for people to feel better. (medlineplus.gov)
- Significant correlations for anxiety, depression, quality of life and illness perception levels were found, indicating relationship between alopecia areata and emotional aspects. (bvsalud.org)
- Androgenetic alopecia is a common form of hair loss in both men and women. (medlineplus.gov)
- Androgenetic alopecia in women rarely leads to total baldness. (medlineplus.gov)
- Additionally, prostate cancer , disorders of insulin resistance (such as diabetes and obesity), and high blood pressure ( hypertension ) have been related to androgenetic alopecia. (medlineplus.gov)
- Androgenetic alopecia affects an estimated 50 million men and 30 million women in the United States. (medlineplus.gov)
- A variety of genetic and environmental factors likely play a role in causing androgenetic alopecia. (medlineplus.gov)
- Researchers suspect that variants (also called mutations) in several genes play a role in androgenetic alopecia. (medlineplus.gov)
- It remains unclear, however, how these genetic changes increase the risk of hair loss in men and women with androgenetic alopecia. (medlineplus.gov)
- Researchers continue to investigate the connection between androgenetic alopecia and other medical conditions, such as coronary heart disease and prostate cancer in men and polycystic ovary syndrome in women. (medlineplus.gov)
- The inheritance pattern of androgenetic alopecia is unclear, because many genetic and environmental factors are likely to be involved. (medlineplus.gov)
- As this is also known as Androgenetic Alopecia, shortened to 'Alopecia' so your hairdresser is most likely correct. (belgraviacentre.com)
- The most common form of hair loss is androgenetic alopecia or patterned hair loss, and it develops gradually with time. (olivaclinic.com)
- Hair loss can affect anyone, but androgenetic alopecia is affecting people as early as in their 20s to 30s. (olivaclinic.com)
- Androgenetic Alopecia - It is a common form of hair loss that can affect both men and women as early as during teenage with the risk increasing with age. (olivaclinic.com)
- In androgenetic alopecia, there is progressive miniaturisation (thinning) of the hair, which causes increased scalp visibility. (olivaclinic.com)
- Heredity - Positive family history can increase your chances of having androgenetic alopecia. (olivaclinic.com)
- At Cosmetic Derma Medicine, Autologous Hair Mesotherapy is applied with great success in many cases of hair loss and alopecia of various causes, especially in cases of androgenetic or diffuse alopecia, in both men and women. (cosmeticdermamedicine.gr)
- It is more common in people who already have androgenetic alopecia. (cosmeticdermamedicine.gr)
- Association between androgenetic alopecia and periodontitis. (bvsalud.org)
- 2x Balance H Hair Tonic Spray Scalp Treatment Alopecia Hair Loss Treatment 100ml. (hairlovestyling.com)
- In this case, the alopecia is usually limited to a desquamating plaque usually on the scalp in a round or oval shape. (cosmeticdermamedicine.gr)
- Sometimes, it can lead to the complete loss of hair on the scalp (alopecia totalis) or, in extreme cases, the entire body (alopecia universalis). (myacare.com)
- I've just decided to get the steroid injections, I have alopecia in my nape area bac of head for over 20 yrs, I've brought every hair growth product and my dermatologist prescribed me a liquid steroid solution to rub on my scalp for over 5 yrs now but I've seem little results and I've always been scared of steroid injections! (alopecia-treatment.com)
- Here, infections were caused by Rickettsia slovaca , resulting in cervical lymphadenopathy (left panel, arrow), inoculation on the scalp (middle panel), and residual alopecia 4 weeks later (right panel). (cdc.gov)
- When I explained that I suffered from Alopecia Universalis, she looked me dead in the eye and said, "Oh, you're one of them," and walked away. (alopeciaworld.com)
- Alopecia Universalis Associated with Vitiligo in an 18-year-old HIV-positive Patient: Highly Active Anti-retroviral Therapy as First Choice Therapy? (medicaljournals.se)
- Alopecia universalis (a) prior to, and (b) after, the introduction of highly active anti-retroviral therapy. (medicaljournals.se)
- A diagnosis of alopecia universalis was made, with a suspicion of concomitant occurrence of vitiligo in association with uncontrolled HIV infection. (medicaljournals.se)
- We therefore diagnosed concomitant occurrence of vitiligo and alopecia universalis in a deeply immunosuppressed HIV-positive patient. (medicaljournals.se)
- To our knowledge this is the first report of the concomitant occurrence of alopecia universalis and vitiligo in an HIV-infected patient with severe immunosuppression and complete healing during the first months of HAART initiation. (medicaljournals.se)
- Alopecia universalis in HIV-positive patients has already been reported (1), and reports linking vitiligo onset with recent HIV infection were made soon after HIV discovery (2). (medicaljournals.se)
- The concomitant presence of vitiligo and alopecia universalis in immunocompetent patients has been reported in a context of severe auto-immune disorders, such as the Vogt-Koyanagi-Harada syndrome (3), or the autoimmune polyglandular syndrome 3-C, which is usually associated with Hashimoto thyroiditis (4). (medicaljournals.se)
- Androgenic alopecia (AGA) is men 's most common form of hair loss . (bvsalud.org)
- Alopecia mucinosa may also manifest as acneiform lesions in young patients. (medscape.com)
- The patient's general condition was good, and complete skin examination revealed diffuse alopecia (Fig. 1a), including the eyelids, as well as depigmented macules scattered through-out the whole skin, but mostly predominant on the legs, presenting as large depigmented macules (Fig. 2a). (medicaljournals.se)
- Mycosis fungoides is recognized at the time of diagnosis in approximately 15-30% of patients with alopecia mucinosa. (medscape.com)
- Pediatric cases comprise most of this type of alopecia mucinosa, with the remainder of patients being younger than 40 years. (medscape.com)
- We searched for studies on the effects of alopecia on various aspects of QOL in breast cancer patients including anxiety and distress, body image, sexuality, self-esteem, social functioning, global QOL and return to work outcomes. (nih.gov)
- The primary efficacy endpoint for THRIVE-AA2 was the percentage of patients achieving an absolute Severity of Alopecia Tool (SALT) score of 20 or less at week 24 of treatment compared to placebo. (khon2.com)
- We encourage clinicians worldwide to report ALL cases of COVID-19 in their alopecia patients treated with systemic immunomodulating medication, regardless of severity (including asymptomatic patients detected through public health screening). (covidderm.org)
- With the collaboration of the international alopecia community, we will rapidly be able to define the impact of COVID-19 on patients with alopecia who are treated with systemic immunomodulating medication and how factors such as age, comorbidities, and systemic immunomodulating treatments impact COVID outcomes. (covidderm.org)
- Through broadscale participation and collaboration, we will be able to answer these very pressing questions for our alopecia patients and their caregivers. (covidderm.org)
- You need to create an account before you can log into the Secure-Alopecia Registry and enrol your patients. (covidderm.org)
- Alopecia mucinosa is a disease process defined histopathologically by mucin deposition in hair follicles and sebaceous glands, which undergo epithelial reticular degeneration. (medscape.com)
- The secondary alopecia mucinosa may be associated with either benign disease or malignant disease. (medscape.com)
- Alopecia mucinosa can occur secondary to benign disease, including the inflammatory conditions lupus erythematosus , lichen simplex chronicus , and angiolymphoid hyperplasia . (medscape.com)
- Alopecia Areta is a disease that causes hair loss on one or multiple body parts. (bvsalud.org)
- Alopecia is a common side effect of chemotherapies used in the treatment of breast cancer. (nih.gov)
- We will provide the alopecia community with regularly updated summary information about reported cases, including numbers of cases by country, number of cases by treatment, etc. so the entire alopecia community has access to these data. (covidderm.org)
- Alopecia hair update and treatment. (alopecia-treatment.com)
- Primary chronic alopecia mucinosa of older persons affects people older than 40 years. (medscape.com)
- Alopecia mucinosa is a rare condition. (medscape.com)
- Which Hair Loss Condition is Alopecia? (belgraviacentre.com)
- My mind has been on alopecia and what is the best way for us to live life to the fullest while living with the condition? (alopeciaworld.com)
- Scarring Alopecia - Also known as cicatricial alopecia , is a rare condition caused when inflammation or scarring due to various diseases hampers the scalp's natural ability to grow hair. (olivaclinic.com)
- Three months after HAART onset, a dramatic and complete response of the alopecia was observed (Fig. 1b), as well as progressive repigmentation of the depigmented macules starting from a perifollicular position (Fig. 2b). (medicaljournals.se)
- Subacute signs and symptoms (onset of days to weeks following ingestion) after a substantial, acute exposure or chronic exposure to limited amounts of thallium might include those of a severely painful ascending neuropathy as well as ataxia, seizures, alopecia, and neurocognitive deficits (1-4). (cdc.gov)
- Now that you understand the different types of alopecia, do you feel like you are ready to live up to my challenge? (salontoday.com)
- Although the question of whether alopecia mucinosa is a transitional state evolving into mycosis fungoides is unresolved, it is proven that alopecia mucinosa may precede the development of mycosis fungoides by several years. (medscape.com)
- It has also been applied with impressive results in many cases of alopecia pedis, even in cases of universal and generalized alopecia pedis, where usually the results of conservative treatments have poor results. (cosmeticdermamedicine.gr)
- We offer the selection and value to meet the needs of most women & children with hair loss & alopecia. (alopeciaworld.com)
- This form of alopecia is of questionable prognosis as it often leads to a total form. (cosmeticdermamedicine.gr)
Leading to hair loss1
- Alopecia mucinosa represents various stages of follicular damage leading to hair loss. (medscape.com)
Quality of l1
- The aim of this review is to describe the effects of alopecia on quality of life (QOL) in this population. (nih.gov)
- The last two reasons include Friction Alopecia and Cheerleading Alopecia . (salontoday.com)
- Thus, additional biopsy specimens and extremely close follow-up care are crucial in all variants of alopecia mucinosa. (medscape.com)
- In the early days of my herbal practise I saw cases of alopecia only infrequently. (homeofherbs.ie)
- Traumatic Alopecia is caused by overusing the following: damaging styling products, extensions, braiding techniques, tight rollers, commercial relaxers, hot irons and combs. (salontoday.com)