Almitrine: A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Dextroamphetamine: The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.Respiratory System Agents: Drugs used for their effects on the respiratory system.Foundations: Organizations established by endowments with provision for future maintenance.Dietetics: The application of nutritional principles to regulation of the diet and feeding persons or groups of persons.Central Nervous System Stimulants: A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Colon, Ascending: The segment of LARGE INTESTINE between the CECUM and the TRANSVERSE COLON. It passes cephalad from the cecum to the caudal surface of the right lobe of the LIVER where it bends sharply to the left, forming the right colic flexure.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Alberta: A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)British Columbia: A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.Health Records, Personal: Longitudinal patient-maintained records of individual health history and tools that allow individual control of access.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Metabolome: The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.Federal Government: The level of governmental organization and function at the national or country-wide level.Research Support as Topic: Financial support of research activities.Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Dog Diseases: Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.Free Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.Nitric Oxide Synthase Type III: A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.Nitric Oxide Donors: A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)PyransBenzopyrans: Compounds with a core of fused benzo-pyran rings.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Calcium Channel Blockers: A class of drugs that act by selective inhibition of calcium influx through cellular membranes.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Hypertension, Renal: Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Nicorandil: A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.Exercise Test: Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.Pulmonary Ventilation: The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)Physical Exertion: Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.Exercise: Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.Exercise Therapy: A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Respiration: The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Exercise Tolerance: The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.

Inhaled NO and almitrine bismesylate in patients with acute respiratory distress syndrome: effect of noradrenalin. (1/32)

The combination of inhaled nitric oxide with almitrine bismesylate has been proposed for the management of acute respiratory distress syndrome in order to divert pulmonary blood flow away from poorly ventilated toward well-ventilated areas. The aims of this prospective and comparative study were to: 1) confirm the beneficial effects on oxygenation of this association; 2) evaluate the haemodynamic effects of this association; and 3) evaluate the influence of noradrenaline (a nonspecific vasoconstrictor) on the modification of gas exchange related to inhaled NO and/or almitrine bismesylate. Forty-one sedated paralysed and ventilated patients were investigated. Haemodynamic and blood gas measurements were performed in a fixed order: baseline; inhalation of NO for 30 min.; intravenous infusion of almitrine bismesylate; and concomitant administration of inhaled NO and almitrine bismesylate. Inhaled NO and almitrine bismesylate increased arterial oxygen tension (Pa,O2)/inspiratory oxygen fraction (FI,O2) (p<0.001). The association of inhaled NO with almitrine bismesylate resulted in a dramatic improvement in Pa,O2/FI,O2 (p<0.0001 versus almitrine bismesylate, p<0.05 versus inhaled NO). In patients receiving noradrenalin (n = 19), almitrine bismesylate had no effect on oxygenation. The present study confirmed that the combination of inhaled NO with almitrine bismesylate improved oxygenation, and demonstrated that almitrine bismesylate has no effect on oxygenation in patients receiving noradrenalin.  (+info)

Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury. (2/32)

BACKGROUND: Inhaled prostacyclin and intravenous almitrine have both been shown to improve pulmonary gas exchange in acute lung injury (ALI). This study was performed to investigate a possible additive effect of prostacyclin and almitrine on pulmonary ventilation-perfusion (VA/Q) ratio in ALI compared with inhaled prostacyclin or intravenous almitrine alone. METHODS: Experimental ALI was established in 24 pigs by repeated lung lavage. Animals were randomly assigned to receive either 25 ng.kg(-1).min(-1) inhaled prostacyclin alone, 1 microg.kg(-1).min(-1) almitrine alone, 25 ng.kg(-1).min(-1) inhaled prostacyclin in combination with 1 microg.kg(-1).min(-1) almitrine, or no specific treatment (controls) for 30 min. For each intervention, pulmonary gas exchange and hemodynamics were analyzed and VA/Q distributions were calculated using the multiple inert gas elimination technique. The data was analyzed within and between the groups by analysis of variance for repeated measurements, followed by the Student-Newman-Keuls test for multiple comparison when analysis of variance revealed significant differences. RESULTS: All values are expressed as mean +/- SD. In controls, pulmonary gas exchange, hemodynamics, and VA/Q distribution remained unchanged. With prostacyclin alone and almitrine alone, arterial oxygen partial pressure (PaO2) increased, whereas intrapulmonary shunt (QS/QT) decreased (P < 0.05). Combined prostacyclin and almitrine also increased PaO2 and decreased QS/QT (P < 0.05). When compared with either prostacyclin or almitrine alone, the combined application of both drugs revealed no additional effect in gas exchange or VA/Q distribution. CONCLUSIONS: The authors conclude that, in this experimental model of ALI, the combination of 25 ng.kg(-1).min(-1) prostacyclin and 1 microg.kg(-1).min(-1) almitrine does not result in an additive improvement of pulmonary gas exchange or VA/Q distribution when compared with prostacyclin or almitrine alone.  (+info)

Association of oral almitrine and medroxyprogesterone acetate: effect on arterial blood gases in chronic obstructive pulmonary disease. (3/32)

Almitrine (A) and medroxyprogesterone acetate (MA) given separately improve arterial blood gases in some patients with chronic obstructive pulmonary disease (COPD); the aim of this study was to assess the effect of the two drugs given together. Forty-eight patients with irreversible COPD and hypoxaemia were prospectively enrolled into a 14-day run-in period and received single-blind oral treatment with double placebo. Patients whose PaO2 remained stable (less than 10% change; n = 29, 25 males, mean age 65.6 years) were included in a 14-day active treatment period and randomly assigned to three groups. They received double-blind oral treatment with: A (50 mg bid, group A, n = 10); MA (20 mg tid, group MA, n = 9); A (50 mg bid) and MA (20 mg tid, group A+MA, n = 10). Anthropometric and spirometric measurements were similar in the three groups and so were the arterial blood gas values at the beginning and the end of the run-in period. At the end of the active treatment period, blood gas changes (mean+/-SE) were significantly different between groups (P<0.05, Kruskal-Wallis test), with improvement in both hypoxaemia and hypercapnia in group A+MA only: delta PaO2 = 7.4+/-1.9 mmHg, delta PaCO2 = -5.1+/-1.7 m mHg (P<0.05, Wilcoxon test). In short-term treatment, the association of A and MA is more efficient than either drug alone at improving arterial blood gases in COPD patients.  (+info)

Effects of almitrine on diaphragm contractile properties in young and old rats. (4/32)

BACKGROUND: Diaphragm muscle force and fatigue are key factors in the development of respiratory failure. Almitrine is used to improve ventilatory drive and ventilation-perfusion matching in respiratory failure. Recently, it has also been shown to improve diaphragm muscle force and endurance in young rats, but it is not known if this effect persists with ageing. OBJECTIVES: To determine the effects of almitrine on diaphragm contractile properties in young and old rats. METHODS: In young and old rats, isometric contractile properties were measured in strips of isolated diaphragm muscle in physiological saline solution at 30 degrees C with or without almitrine. RESULTS: In young animals, almitrine increased twitch tension, reduced half-relaxation time and increased endurance, but had no effect on tetanic tension, contraction time or tension-frequency relationship. Ageing had no effect on endurance, but did reduce twitch and tetanic tension and contraction and half-relaxation time. Almitrine had no effect on contractile tension and kinetics, tension-frequency relationship or on endurance in the old animals. CONCLUSIONS: Ageing negates the beneficial effects of almitrine on diaphragm muscle force and endurance.  (+info)

An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue. (5/32)

BACKGROUND: Previous studies have shown that almitrine bismesylate, a respiratory stimulant which acts on the mitochondrial electron transport chain, enhances recovery of rat diaphragm muscle from fatigue. OBJECTIVES: Our aim is to investigate if the enhanced recovery is due to an anti-oxidant property of almitrine, since the electron transport chain is a major site of intracellular free radical production. METHODS: A low-frequency fatigue protocol was used (30 Hz; 250 ms; delivered once every 2 s for 5 min), and the effects of almitrine before and after fatigue onset were compared to those of the anti-oxidant compound N-acetylcysteine (NAC). RESULTS: Almitrine (6 and 10 microg/ml) given before fatigue gave better recovery rates than postfatigue application. In contrast, NAC (100 microM) application before fatigue onset was not as effective as NAC given immediately after the cessation of the fatigue protocol. However, almitrine (6 microg/ml) completely reversed the reduction in baseline twitch tension brought about by a free-radical-producing mixture of FeCl(3) + ADP (1 mM + 2.5 mM, respectively). CONCLUSION: The results of this study confirm that almitrine enhances recovery from fatigue and, in contrast to NAC prefatigue application, is more effective. Also, almitrine was shown to have an anti-oxidant effect, but it does not act like a typical anti-oxidant.  (+info)

Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury. (6/32)

In a porcine model of oleic acid-induced lung injury, the effects of inhaled nitric oxide (iNO) and intravenous almitrine bismesylate (ivALM), which enhances the hypoxic pulmonary vasoconstriction on the distribution of regional pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets [weight of 25 +/- 2.6 (SD) kg] were randomly divided into four groups: supine position, prone position, and 10 ppm iNO for 40 min followed by 4 microg x kg(-1) x min(-1) ivALM for 40 min in supine position and in prone position. PBF was measured with positron emission tomography and H(2)15O. The redistribution of PBF was studied on a pixel-by-pixel basis. Positron emission tomography scans were performed before and then 120, 160, and 200 min after injury. With prone position alone, although PBF remained prevalent in the dorsal regions it was significantly redistributed toward the ventral regions (P < 0.001). A ventral redistribution of PBF was also obtained with iNO regardless of the position (P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.  (+info)

Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study. (7/32)

BACKGROUND: Advanced chronic obstructive pulmonary disease (COPD) generates high costs, especially when patients require domiciliary long-term oxygen therapy (LTOT). Almitrine bismesylate has been shown to improve gas exchange in the lungs. Our hypothesis was that long-term treatment with almitrine might postpone the prescription of LTOT. OBJECTIVE: To evaluate the effects of almitrine sequential treatment on arterial blood gases in COPD patients with moderate hypoxaemia. METHODS: COPD patients with moderate hypoxaemia [partial oxygen tension in arterialised blood (PaO(2)) between 7.33 and 8.66 kPa (56-65 mm Hg)] were investigated. After a 1-month run-in period, patients were given either almitrine 100 mg per day or placebo for sequential treatment for a total of 12 months. RESULTS: 115 patients in a steady state (57 in the almitrine and 58 in the placebo group) were included. Mean age was 60 years, mean forced expiratory volume in 1 s was 34 +/- 13% of predicted and mean PaO(2) was 8.04 +/- 0.5 kPa (60.5 +/- 3.8 mm Hg). 38 patients were lost to follow-up, 23 in the almitrine and 15 in the placebo group. The majority of drop-outs were due to adverse events (AE; 16 in the almitrine and 9 in the placebo group). Almitrine treatment resulted in PaO(2) improvement of 0.43 +/- 0.88 kPa (3.2 +/- 6.6 mm Hg) (p = 0.003). The treatment effect between almitrine and placebo was 0.45 kPa (3.4 mm Hg) (p = 0.003). In the almitrine group, two distinct subgroups were observed: responders (n = 19) and non-responders (n = 38). Almitrine treatment in responders resulted in a clinically significant improvement in PaO(2) of 1.36 +/- 0.7 kPa (10.2 +/- 5.3 mm Hg) (p < 0.0001) and a reduction of partial carbon dioxide tension in arterialised blood. 31 patients experienced serious AE: 17 in the almitrine and 14 in the placebo group. Five patients died during the study (3 in the almitrine and 2 in the placebo group). Most AE occurring during the study were related to underlying disease. Clinical diagnosis of polyneuropathy resulted in the withdrawal of 5 patients in the almitrine group and 3 patients in the placebo group. Four patients in the almitrine group experienced weight loss. CONCLUSIONS: Almitrine treatment of patients with severe COPD and moderate hypoxaemia resulted in a small but significant improvement in PaO(2) over 12 months. A clinically important improvement in gas exchange was observed in 33% of treated patients. These patients may be candidates for long-term treatment.  (+info)

An analysis of the action of an analogue of almitrine bismesylate in the rat model of hypoxic lung disease. (8/32)

Chronically hypoxic (CH) and normoxic control rats were used to assess the action of S9581, a water-soluble analogue of almitrine bismesylate. S9581 increased ventilation (Ve) by 34% in control and 20% in CH rats. During acute hypoxia Ve was raised and S9581 caused a further increase of 20% in both groups. Low doses of S9581 and almitrine enhanced the hypoxic ventilatory response in CH rats while high doses depressed it in both groups. Effects of S9581 on the pulmonary circulation were assessed in the isolated perfused lung of rats. As with almitrine a complex relationship of dose-dependent vasoconstriction and dilatation was revealed. In low doses, S9581 enhanced the hypoxic pulmonary vasoconstrictor response to 2% O2 whilst this was attenuated by high doses in both control and CH rats. S9581 seemed to act like almitrine bismesylate on both the ventilation (peripheral chemoreceptor) and the pulmonary circulation. For studying almitrine-like activity the water solubility of S9581 provides considerable advantages for the researcher.  (+info)

*Almitrine

... (marketed as Duxil by Servier) is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ... They summarize two studies in which almitrine-raubasine improved some symptoms significantly more than placebo, especially in ... The clinical efficacy of almitrine-raubasine combination therapy for age related cerebral disorders and functional ... Flunarizine Diphenylmethylpiperazine Servier Allain, H.; Bentué-Ferrer, D. (1998). "Clinical Efficacy of Almitrine-Raubasine". ...

*List of drugs: Al

... almitrine (INN) almokalant (INN) Almora almorexant INN almotriptan (INN) almoxatone (INN) almurtide (INN) alnespirone (INN) ...

*List of MeSH codes (D03)

... almitrine MeSH D03.383.931.135 --- altretamine MeSH D03.383.931.190 --- apazone MeSH D03.383.931.247 --- atrazine MeSH D03.383. ... almitrine MeSH D03.383.606.290 --- cinnarizine MeSH D03.383.606.320 --- cyclizine MeSH D03.383.606.350 --- delavirdine MeSH ...

*Laboratoires Servier

Other products: Agomelatine (Valdoxan, Melitor, Thymanax) Almitrine (Duxil, Vectarion) Amineptine (Survector, Maneon, Directim ...

*ATC code R07

Doxapram R07AB02 Nikethamide R07AB03 Pentetrazol R07AB04 Etamivan R07AB05 Bemegride R07AB06 Prethcamide R07AB07 Almitrine ...

*GAL-021

... is a drug related to almitrine which acts as a respiratory stimulant, with its mechanism of action primarily thought to ...
[150 Pages Report] Check for Discount on Global and Chinese Almitrine dimesylate (CAS 29608-49-9) Industry, 2016 Market Research Report report by Prof Research. The Global and Chinese Almitrine dimesylate Industry, 2011-2021 Market...
1. To test whether almitrine might improve the arterial partial pressure of O2 in patients with chronic obstructive airways disease by improvement of ventilation-perfusion matching, we looked at the interaction between hypoxic and almitrine-induced vasoconstriction in isolated rat lungs perfused with blood at constant flow. Increases in pressure represented increases in resistance.. 2. Almitrine, given in increasing doses between challenges with 2% O2, enhanced hypoxic vasoconstriction at low doses but attenuated it at high doses.. 3. Stimulus-response curves to hypoxia of increasing severity gave a sigmoid curve.. 4. Almitrine solvent caused small changes in pulmonary artery pressure and shifted the stimulus-response curve slightly in a parallel fashion.. 5. Small doses of almitrine enhanced the action of mild to moderate hypoxia, medium doses attenuated moderately severe hypoxia, whereas high doses depressed vasoconstriction due to all degrees of hypoxia.. 6. These effects of almitrine on ...
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One of the 3 following criteria of disease severity:. i. PaO2/FiO2 , 50 mm Hg with FiO2 ≥ 80% for , 3 hours, despite optimization of mechanical ventilation (Vt set at 6 ml/kg and trial of PEEP ≥ 10 cm H2O) and despite possible recourse to usual adjunctive therapies (NO, recruitment maneuvers, prone position, HFO ventilation, almitrine infusion) OR. ii. PaO2/FiO2 , 80 mm Hg with FiO2 ≥ 80% for , 6 hours, despite optimization of mechanical ventilation (Vt set at 6 ml/kg and trial of PEEP ≥ 10 cm H2O) and despite possible recourse to usual adjunctive therapies (NO, recruitment maneuvers, prone position, HFO ventilation, almitrine infusion) OR. iii. pH , 7.25 (with PaCO2 ≥60 mm Hg) for , 6 hours (with respiratory rate increased to 35/min) resulting from MV settings adjusted to keep plat ≤ 32 cm H2O (first, tidal volume reduction by steps of 1 mL/kg to 4 mL/kg then PEEP reduction to a minimum of 8 cm H2O.. ...
The plasticity of synaptosomal non-mitochondrial ATPases was evaluated in cerebral cortex from 3-month-old normoxic rats and rats subjected to either mild or severe intermittent normobaric hypoxia [12 hr daily exposure to N2:O2 (90:10 or 91.5:8.5) for four weeks]. The activities of Na+, K(+)-ATPase, low- and high-affinity Ca(2+)-ATPase, Mg(2+)-ATPase, and Ca2+,Mg(2+)-ATPase were assayed in synaptosomes and synaptosomal subfractions, namely synaptosomal plasma membranes and synaptic vesicles. The evaluations were performed after a 4-week treatment with saline (controls) or alpha-adrenergic agents (delta-yohimbine, clonidine), a vasodilator compound (papaverine), and an oxygen-partial pressure increasing agent (almitrine). These treatments differently changed the adaptation to chronic intermittent hypoxia characterized by a decrease in the activity of Na+,K(+)-ATPase, Ca2+,Mg(2+)-ATPase, and high-affinity Ca(2+)-ATPase, concomitant with a modification in the activity of Mg(2+)-ATPase supported in ...
A Learning Pack On Arterial Blood Gases For New Starters and ... ... www.resus.org.uk/pages/alsmBGap.pdf) ABGs are ... 35 HCO3 -18 mmols This is a response by the respiratory system ... A Learning Pack On Arterial Blood Gases For New .... ...
Information, Tools, and Resources to aid Primary Care Physicians in caring for Children with Special Health Care Needs (CSHCN) and providing a Medical Home for all of their patients.
For this study, researchers selected the gastrodine compound granule. It s extracted from tall gastrodia tuber plants and six other herbs and is the first of new herbal drugs in dementia to be tested in clinical trials. The 12-week, randomized, double-blind trial was done in Beijing Dongzhimen Hospital, one of the hospitals running the clinical trials between 1999 and 2002. Researchers identified 120 stroke patients (75 male 45 female) who were diagnosed with mild to moderate VaD lasting three months or more. All patients were assessed for VaD at baseline and randomly divided into two treatment groups. One group (70 patients) was given one bag of the gastrodine compound granule (2.6 milligram gastrodine) three times a day for 12 weeks. The second group (50 patients) was given 40 mg of Duxilâ (almitrine + raubasine) three times a day for 12 weeks. This is a drug used to treat stroke patients in China. Both the gastrodine compound granule and the Duxilâ granule were dissolved in hot water and ...
30. Baker concluded that Barrett suffers a moderate impairment and lacks the respiratory capacity to perform the work of a coal miner or comparable work in a dust-free environment. J.A. at 120. The ALJ noted that Bakers opinion was based not only on the March 28, 2000 pulmonary function test, which was determined to be invalid, but also on a subsequent pulmonary function test that did produce qualifying results and on arterial blood gas studies which indicated that Barrett had "mild resting arterial hypoxemia." J.A. at 222. The ALJ concluded that, "[w]hile the weight of the valid and conforming pulmonary function tests alone constitutes probative evidence of total disability, when combined with the arterial blood gases, which provide no evidence of total disability, and the medical opinions, which weigh in favor of a finding of total disability, the weight of the evidence directs a finding of total disability." J.A. at 223. In rejecting Dr. Dahhans opinion to the contrary, the ALJ noted that ...
cor pulmonale - MedHelps cor pulmonale Center for Information, Symptoms, Resources, Treatments and Tools for cor pulmonale. Find cor pulmonale information, treatments for cor pulmonale and cor pulmonale symptoms.
No cotidiano da medicina veterinária a cesariana é uma técnica cirúrgica bastante empregada. Qualquer que seja o protocolo anestésico escolhido, a droga atuará direta ou indiretamente sobre os fetos, causando depressão das funções vitais do neonato e contribuindo para dificultar sua adaptação à vida extra-uterina. Na tentativa de reverter no neonato os efeitos depressores da anestesia usada na mãe, recomenda-se a aplicação do cloridrato de doxapram e/ou aminofilina. Este trabalho objetivou estudar a eficácia do cloridrato de doxapram e da aminofilina associados ou não, na reanimação de neonatos caninos após cesariana eletiva, bem como comparar a via sublingual com a subcutânea para a administração dessas drogas. Foram avaliados um total de 64 filhotes, distribuídos em oito grupos de oito animais cada. Quatro destes grupos receberam as drogas por via subcutânea (sC) e os outros quatro via sublingual (sL). Dois grupos (G1sC e G1sL) receberam apenas placebo; outros dois ...
Doxapram hydrochloride (marketed as Dopram, Stimulex or Respiram) is a respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem. Doxapram is a white to off-white, odorless, crystalline powder that is stable in light and air. It is soluble in water, sparingly soluble in alcohol and practically insoluble in ether. Injectable products have a pH from 3.5-5. Benzyl alcohol or chlorobutanol is added as a preservative agent in the commercially available injections. Doxapram is used in intensive care settings to stimulate the respiratory rate in patients with respiratory failure. It may be useful for treating respiratory depression in patients who have taken excessive doses of drugs such as buprenorphine or fentanyl analogues which may fail to respond adequately to treatment with naloxone. It ...
inproceedings{2101216, author = {Schauvliege, Stijn and Savvas, I and Gasthuys, Frank}, booktitle = {AVA spring meeting Davos 2012}, language = {eng}, location = {Davos, Switzerland}, pages = {34--34}, publisher = {Association of Veterinary Anaesthetists (AVA)}, title = {The effect of pure oxygen or air/oxygen mixture on arterial blood oxygenation in spontaneously ventilated isoflurane anaesthetized horses: a retrospective study}, year = {2012 ...
OBJECTIVE: To evaluate impact of a computer-based intervention on arterial blood gas (ABG) usage in an intensive care setting. DESIGN: Retrospectively examined, via mixed group analysis, the effects of the intervention on ABG usage in the intensive care unit (ICU). SUBJECTS: Included all clinicians who placed ABG orders in an ICU using the computerized physician order-entry system, as well as controls in non-order entry units. METHODS: Computer-based intervention presenting ordering clinician with patient s previous ABG values and limiting forward duration of tests ordered. Study spanned 12 weeks, 5 weeks pre-intervention and 7-weeks post-intervention. Of 8 ICUs, intervention implemented in 6, not implemented in 2. Data analyzed using the repeated measure ANOVA. RESULTS: Physicians entered ...
Critical Care Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of critical care medicine.
Job aids illustrating key steps for each of the blood drawing procedures were developed to make the phlebotomy guidelines more user friendly. These job aids are meant for end-users in order to have information readily available. The cards and their holder can be printed, cut and folded to fit in a pocket. (Card 3 of 8) ...
He was one of the pioneers of the study of plant alkaloid chemistry. Alkaloids are organic compounds that induce various effects in medicine, including painkillers and respiratory stimulants. Pelletier and his colleagues first isolated the pigment chlorophyll in 1817 ...
To the editor: Zwillich and co-workers presented an interesting paper on theophylline-induced seizures in the June 1975 issue (Ann Intern Med 83:784-787). I wonder if they obtained arterial blood gases either just prior to, or during the seizure in any of their patients. I know the authors are well aware that theophylline can be a respiratory stimulant (1) and that respiratory alkalosis can cause seizures (2). Could theophylline, at the high levels noted in their patients, be such a marked respiratory stimulant as to lead to severe alkalosis and seizures? If this is the explanation, it obviously would affect the ...
Thank you for your interest in our paper and for your comments. As was correctly pointed out in the letter, patients who are kept NPO should be given IV glucose supplementation. This was not done for our patient and this is indeed one of the reasons we decided to present her case in the Learning from errors section of the journal. We would like to clarify that it is in fact very unlikely for a non- breastfeeding patient to become significantly acidotic secondary to having no caloric intake for three days. Our bodies are normally well equipped to deal with short term starvation and only mild levels of acidosis develop in the starvation state when insulin levels are normal. In a small study published by Reidenberg et al., obese (non-lactating) women were starved for over a month and this produced only a mild metabolic acidosis of approximately 7.35 on arterial blood gas analysis. 1 On the other hand, Mohammad et al. showed that when lactating women are fasting for more than 42 hours, they begin to ...
Schweizerische Gesellschaft für Pulmonale Hypertonie - Information der Ärzteschaft und der Bevölkerung über die Pulmonale Hypertonie
Schweizerische Gesellschaft für Pulmonale Hypertonie - Information der Ärzteschaft und der Bevölkerung über die Pulmonale Hypertonie
The free 3DCT Viewer must be installed before this slide will work in PowerPoint.. Click the link and open or save the slide to your computer. Upon opening the file, if you see a RED X, click the OPTIONS box on your security warning and select ENABLE THIS CONTENT. Then start the slide show to enable the 3D view. Rotate the model by holding the LEFT click button and dragging with your mouse. Zoom in and out by holding the RIGHT click button and dragging your mouse up and down. Translate the model by holding both RIGHT and LEFT buttons and dragging your mouse. All 3DCT models are not shown to scale. Experiment your viewing experience by clicking the MENU button and turning various options on and off.. ...
Cyanosis is the bluish or purplish discolouration of the skin or mucous membranes due to the tissues near the skin surface having low oxygen saturation. Based on Lundsgaard and Van Slykes work,[1] it is classically described as occurring if 5.0 g/dL of deoxyhemoglobin or greater is present.[2] This was based on an estimate of capillary saturation based on a mean of arterial versus peripheral venous blood gas measurements.[3] Since estimation of hypoxia is usually now based either on arterial blood gas measurement or pulse oximetry, this is probably an overestimate, with evidence that levels of 2.0 g/dL of deoxyhemoglobin may reliably produce cyanosis.[4] Since, however, the presence of cyanosis is dependent upon there being an absolute quantity of deoxyhemoglobin, the bluish color is more readily apparent in those with high hemoglobin counts than it is with those with anemia. Also, the bluer the color, the more difficult it is to detect on deeply pigmented skin. When signs of cyanosis first ...
Chronically low blood levels of oxygen may lead to pulmonary hypertension (high blood pressure in the arteries of the lungs), and possibly to cor pulmonale. Cor pulmonale is also called right-sided heart failure, and is characterized by enlargement of the right ventricle. Treatment targets the underlying illness and may include supplemental oxygen, a low-salt diet or diuretics (water pills ...
If you know anything about Bronchiectasis, COPD and Cor Pulmonale, I sure could use your help!!!! I have just found out that my moth...

Almitrine - WikipediaAlmitrine - Wikipedia

Almitrine (marketed as Duxil by Servier) is a diphenylmethylpiperazine derivative classified as a respiratory stimulant by the ... They summarize two studies in which almitrine-raubasine improved some symptoms significantly more than placebo, especially in ... The clinical efficacy of almitrine-raubasine combination therapy for age related cerebral disorders and functional ... Flunarizine Diphenylmethylpiperazine Servier Allain, H.; Bentué-Ferrer, D. (1998). "Clinical Efficacy of Almitrine-Raubasine". ...
more infohttps://en.wikipedia.org/wiki/Almitrine

Are peripheral nerve disorders associated with almitrine? | Springer for Research & DevelopmentAre peripheral nerve disorders associated with almitrine? | Springer for Research & Development

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves ...
more infohttps://rd.springer.com/article/10.1007/BF03283628

Does the Stimulation of Peripheral Arterial Chemoreceptors in Humans by Almitrine Bismesylate Inhibit Proximal Tubular...Does the Stimulation of Peripheral Arterial Chemoreceptors in Humans by Almitrine Bismesylate Inhibit Proximal Tubular...

Bardsley, P. A., and Suggett, A. J., 1987, The carotid body and natriuresis: Effect of almitrine bismesylateBiomed. Biochim ... Labrid, C., 1984, Experimental trials and development of almitrine bismesylateMedicographia, 6:356.Google Scholar ... Laubie, M., and Schmitt, H., 1980, Long lasting hyperventilation inducedby almitrine: Evidence for a specific effect on carotid ... Does the Stimulation of Peripheral Arterial Chemoreceptors in Humans by Almitrine Bismesylate Inhibit Proximal Tubular ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-8938-5_43

Interactions between hypoxic and almitrine-induced vasoconstriction in the rat lung | Clinical Science | Portland PressInteractions between hypoxic and almitrine-induced vasoconstriction in the rat lung | Clinical Science | Portland Press

Interactions between hypoxic and almitrine-induced vasoconstriction in the rat lung P. C. Russell P. C. Russell ... The Effects of Almitrine on the Ventilatory Response to Hypoxia and Hypercapnia in Normal Subjects Clin Sci (Lond) (October, ... 4. Almitrine solvent caused small changes in pulmonary artery pressure and shifted the stimulus-response curve slightly in a ... 2. Almitrine, given in increasing doses between challenges with 2% O2, enhanced hypoxic vasoconstriction at low doses but ...
more infohttps://portlandpress.com/clinsci/article-abstract/82/3/265/75676/Interactions-between-hypoxic-and-almitrineinduced

Global and Chinese Almitrine dimesylate (CAS 29608-49-9) Industry, 2016 Market Research Report : ReportsnReportsGlobal and Chinese Almitrine dimesylate (CAS 29608-49-9) Industry, 2016 Market Research Report : ReportsnReports

The Global and Chinese Almitrine dimesylate Industry, 2011-2021 Market... ... 150 Pages Report] Check for Discount on Global and Chinese Almitrine dimesylate (CAS 29608-49-9) Industry, 2016 Market Research ... 8.3 Effects to Almitrine dimesylate Industry Chapter Nine Market Dynamics of Almitrine dimesylate Industry 9.1 Almitrine ... 1.1 Brief Introduction of Almitrine dimesylate 1.2 Development of Almitrine dimesylate Industry 1.3 Status of Almitrine ...
more infohttp://www.reportsnreports.com/reports/593088-global-and-chinese-almitrine-dimesylate-cas-29608-49-9-industry-2016-market-research-report.html

ALMITRINE BISMESYLATE manufacturing companiesALMITRINE BISMESYLATE manufacturing companies

We are sorry, there are no companies found in " ALMITRINE BISMESYLATE" Listing your company for ALMITRINE BISMESYLATE allows ... ALMITRINE BISMESYLATE manufacturers and suppliers. Search. Search by Drug Name, Company, CAS, Chem formula, IUPAC Name, Country ...
more infohttp://www.poulvet.com/bulk_drugs/product_companies_india.php?sclid=1658&prefix=J

Meylers Side Effects of Drugs - Elsevier Science & Technology - Literati by CredoMeyler's Side Effects of Drugs - Elsevier Science & Technology - Literati by Credo

This updated edition in the long standing series provides the latest information on many individual drugs, including the most complete coverage of their adverse reactions and interactions.
more infohttps://corp.credoreference.com/component/booktracker/edition/11102.html

Drugs - DrugBankDrugs - DrugBank

Almitrine. 477.5522. C26H29F2N7. For the treatment of chronic obstructive pulmonary disease.. Respiratory System Agents. ...
more infohttps://www.drugbank.ca/drugs?approved=1&c=name&d=up&page=3&type=biotech

IDS Group productsIDS Group products

Almitrine Dimesylate; Raubasine. Dysport. Botulinum Toxin Type A. Ebixa. Memantine Hydrochloride. Efexor XR. Venlafaxine ...
more infohttp://drugs-about.com/firms/ids-group.html

Averting Opioid-induced Respiratory Depression without Affecting Analgesia | Anesthesiology | ASA PublicationsAverting Opioid-induced Respiratory Depression without Affecting Analgesia | Anesthesiology | ASA Publications

... almitrine, and doxapram, GAL021 also acts as a K+-channel blocker at the carotid bodies. Similar to almitrine, it acts through ... almitrine reversed fentanyl-induced respiratory depression without affecting analgesia.102 However, almitrine does not ... Almitrine is a piperazine derivative that induces long-lasting stimulation of ventilation and increases the slope of the ... In dogs, almitrine was shown to antagonize the depressant effects of fentanyl on respiratory neurons recorded in anesthetized ...
more infohttps://anesthesiology.pubs.asahq.org/article.aspx?articleid=2675905

August 2019 - Volume 129 - Issue 2 : Anesthesia & AnalgesiaAugust 2019 - Volume 129 - Issue 2 : Anesthesia & Analgesia

Evaluation of Almitrine Infusion During Veno-Venous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress ...
more infohttps://journals.lww.com/anesthesia-analgesia/toc/2019/08000

Role of Nitric Oxide in Sepsis and ARDS | M.P. Fink | SpringerRole of Nitric Oxide in Sepsis and ARDS | M.P. Fink | Springer

Almitrine and Inhaled Nitric Oxide in Acute Respiratory Failure. Payen, D. M. (et al.) ...
more infohttp://www.springer.com/us/book/9783642799228

Nanyang Tianhua Pharmaceutical Co.,Ltd. | CPhI ChinaNanyang Tianhua Pharmaceutical Co.,Ltd. | CPhI China

Almitrine bismesylate(29608-49-9?,Bethanechol chloride?590-63-6),Chlorzoxazone(95-25-0),Probenecid(57-66-9),Tiopronin(1953-02-2 ... Almitrine bismesylate(29608-49-9?,Bethanechol chloride?590-63-6),Chlorzoxazone(95-25-0),Probenecid(57-66-9),Tiopronin(1953-02-2 ...
more infohttps://www.cphi.com/china/exhibitors/nanyang-tianhua-pharmaceutical-coltd

Browse Cochrane - Essential Evidence PlusBrowse Cochrane - Essential Evidence Plus

Almitrine-Raubasine combination for dementia Cochrane Systematic Reviews, 15-Feb-2011 Almitrine-raubasine combination (brand ...
more infohttp://www.essentialevidenceplus.com/content/cochrane?class=Psych

Active Pharmaceutical Ingredients (API)-Genemed Synthesis Inc.Active Pharmaceutical Ingredients (API)-Genemed Synthesis Inc.

ALMITRINE. API/Drugs Intermediate. Bulk. Contact Sales API-129. ALPROSTADIL. API/Drugs Intermediate. Bulk. Contact Sales ...
more infohttp://genemedsyn.com/commerce/catalog/spcategory.jsp?category_id=1091&start=26&czuid=1518542772015

Healthy Skepticism | MaLAM International News and MaLAM lettersHealthy Skepticism | MaLAM International News and MaLAM letters

Almitrine/raubasine said to be "the first drug to improve cerebral arterial oxygen content" and to provide "major benefits in ... Servier Arcalion (sulbutiamine) and Duxaril (almitrine/raubasine). Vol 13 Issue 5 This month: Serviers promotion of Arcalion ( ... Follow up letter to Servier re promotion of Arcalion (sulbutiamine) and Duxaril (almitrine/raubasine) in the Philippines - ... Servier Arcalion (sulbutiamine) and Duxaril (almitrine/raubasine). Vol 14 Issue 2 Misleading drug promotion and inappropriate ...
more infohttp://www.healthyskepticism.org/global/malam

Application # 2017/0049777. COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES - Patents.comApplication # 2017/0049777. COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES - Patents.com

TABLE-US-00001 TABLE 1 Drug Name CAS number acamprosate 77337-76-9; 77337-73-6 almitrine 27469-53-0; 29608-49-9 amlexanox 68302 ... almitrine from about 0.5 to 10 mg per day, preferably orally, [0175] amlexanox from about 0.75 to 15 mg per day, preferably ... drug selected from almitrine, amlexanox, azelastine, baclo fen, carbetapentane, cimetidine, cinacalcet, dexbrompheniramine, ... almitrine, amlexanox, azelastine, baclo fen, carbetapentane, cimetidine, cinacalcet, dexbrompheniramine, diethylcarbamazine, ...
more infohttp://patents.com/us-20170049777.html

DementiaDementia

Sixty patients were allocated to acupuncture or medication (almitrine). The overall clinical effective rate was 83.3% for ... A randomised controlled trial that compared electroacupuncture (EA) with medication (almitrine) in 60 patients with vascular ...
more infohttps://www.acupuncture.org.uk/a-to-z-of-conditions/a-to-z-of-conditions/3202-dementia.html?print=1&tmpl=component

Table of Contents - September 01, 1982, 63 (3) | Clinical ScienceTable of Contents - September 01, 1982, 63 (3) | Clinical Science

Effect of Almitrine on Pulmonary Gas Exchange in Dogs J. M. B. Hughes, D. J. Allison, A. Goatcher, A. Tripathi ... Ventilation and Breathing Pattern in Rats Caused by Changes in Respiratory Gas Tensions and Almitrine D.P. Dhillon, G.R. Barer ...
more infohttp://www.clinsci.org/content/63/3

DementiaDementia

Sixty patients were allocated to acupuncture or medication (almitrine). The overall clinical effective rate was 83.3% for ... A randomised controlled trial that compared electroacupuncture (EA) with medication (almitrine) in 60 patients with vascular ...
more infohttps://www.acupuncture.org.uk/a-to-z-of-conditions/a-to-z-of-conditions/3202-dementia.html

Hampl+V[AU]NOT(Flegr+J[AU])NOT(Roger*[AU])NOT(Parasito*[ALL])NOT(Paras - PubMed - NCBIHampl+V[AU]NOT(Flegr+J[AU])NOT(Roger*[AU])NOT(Parasito*[ALL])NOT(Paras - PubMed - NCBI

Almitrine in low dose potentiates vasoconstrictor responses of isolated rat lungs to moderate hypoxia. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Hampl%2BV%5BAU%5DNOT

Adult respiratory distress syndrome information from Wikipedia - RightDiagnosis.comAdult respiratory distress syndrome information from Wikipedia - RightDiagnosis.com

Almitrine bismesylate stimulates chemoreceptors in carotic and aortic bodies. It has been used to potentiate the effect of NO, ...
more infohttps://www.rightdiagnosis.com/a/adult_respiratory_distress_syndrome/wiki.htm

Hypertension sub-cluster 1Hypertension sub-cluster 1

It has been suggested that almitrine improves the local ventilation/perfusion ratio by enhancing hypoxic pulmonary ... Nifedipine inhibits the effects of almitrine in patients suffering from pulmonary artery ... ...
more infohttp://www.biomedsearch.com/cluster/89/Hypertension/sub-1-p8.html

Search Results | PORTSearch Results | PORT

Interactions between hypoxic and almitrine-induced vasoconstriction in the rat lung P. C. Russell, C. J. Emery, J. Nicholl, G. ... 4. Almitrine solvent caused small changes in pulmonary artery pressure and shifted the stimulus-response curve slightly in a ... 2. Almitrine, given in increasing doses between challenges with 2% O 2 , enhanced hypoxic vasoconstriction at low doses but ... 8. Almitrine-induced vasoconstriction was attenuated by a fall in perfusate temperature in a similar manner to hypoxic ...
more infohttps://portlandpress.com/clinsci/search-results?f_Authors=P.+Howard
  • 1. To test whether almitrine might improve the arterial partial pressure of O 2 in patients with chronic obstructive airways disease by improvement of ventilation-perfusion matching, we looked at the interaction between hypoxic and almitrine-induced vasoconstriction in isolated rat lungs perfused with blood at constant flow. (portlandpress.com)
  • Severe hypoxemia associated with liver disease:mayo Clinic experience and the experimental use of almitrine bisemesylate. (medigraphic.com)
  • The clinical efficacy of almitrine-raubasine combination therapy for age related cerebral disorders and functional rehabilitation after stroke has been reviewed by Allain and Bentué-Ferrer. (wikipedia.org)
  • Laubie, M., and Schmitt, H., 1980, Long lasting hyperventilation inducedby almitrine: Evidence for a specific effect on carotid and thoracic chemoreceptors Eur. (springer.com)
  • The report provides key statistics on the market status of the Almitrine dimesylate manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. (reportsnreports.com)
  • The ''Global and Chinese Almitrine dimesylate Industry, 2011-2021 Market Research Report'' is a professional and in-depth study on the current state of the global Almitrine dimesylate industry with a focus on the Chinese market. (reportsnreports.com)
  • Through the statistical analysis, the report depicts the global and Chinese total market of Almitrine dimesylate industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. (reportsnreports.com)
  • Overall, the report provides an in-depth insight of 2011-2021 global and Chinese Almitrine dimesylate industry covering all important parameters. (reportsnreports.com)