A synthetic steroid with progestational activity.
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.

The effect of synthetic gestagens on progesterone formation in vitro in human placenta of early pregnancy. (1/5)

Villous tissue from 26 placentae of 7-17 weeks was incubated with radioactive pregnenolone alone and with pregnenolone in the presence of progesterone and 9 synthetic gestagenic steroids and the progesterone formation was measured after 30 min. When progesterone was present in a concentration of 31 or 310 mumol/1 the conversion rate of labelled pregnenolone to progesterone was reduced to 88.6 and 82.2% of that of the respective control incubations. Dydrogesterone, allyloestrenol, lynoestrenol and norethynodrel under similar conditions did not inhibit the formation of progesterone. The inhibitory effects of megoestrol acetate, medroxyprogesterone acetate and norgestrel were close to that of progesterone. Norethisterone and methyloestrenolone were the most effective inhibitors of progesterone formation: when incubated in an equimolar concentration (35 mumol/1) with pregnenolone (50 microgram) the progesterone formation was reduced to 60.0-62.7% and 29.1-34.0% respectively of that of the respective control experiments.  (+info)

Recovery of serum prostate specific antigen value after interruption of antiandrogen therapy with allylestrenol for benign prostatic hyperplasia. (2/5)

Decrease in serum prostate specific antigen (PSA) concentration is inevitably associated with antiandrogen therapy for benign prostatic hyperplasia (BPH), and might mask the presence of prostate cancer or delay its diagnosis. To determine the appropriate timepoint for determination of correct PSA value, we sequentially measured serum PSA and testosterone levels after discontinuation of antiandrogen therapy for BPH. With informed consent, 12 patients (72.8 +/- 12.2* years old) with BPH were treated with allylestrenol 50 mg/day for 4 months. Serum testosterone and PSA concentrations were determined before and just after treatment, as well as every month after treatment up to 3 months. After treatment with allylestrenol for 4 months, mean serum testosterone and PSA levels were significantly decreased from 408 +/- 136* to 87.9 +/- 76.2* ng/dl, and from 2.81 +/- 0.87* to 2.04 +/- 0.82* ng/ml, respectively. The mean serum PSA level recovered to the pretreatment level within 2 months and mean serum testosterone concentration within one month after discontinuation of administration. In conclusion, during treatment of BPH with antiandrogen allylestrenol, a two-month washout is adequate for determination of correct PSA value (*: M +/- SD).  (+info)

A case of suspected teratogenic holoprosencephaly. (3/5)

A case of holoprosencephaly is reported in which the mother was prescribed high doses of oestroprogestins during the first 5 months of the pregnancy. Investigation of the family failed to reveal any sign of physical abnormality. A normal karyotype was detected in the proband. The authors suggest that this case may shed some light on the normal and abnormal way in which embryonic fields develop.  (+info)

Effects of a new non-steroidal 5 alpha-reductase inhibitor, FK143, on the prostate gland in beagle dogs. (4/5)

FK143 (4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]-1H-indol-1-yl] - butyric acid) is a new non-steroidal inhibitor of steroid 5 alpha-reductase (5 alpha-reductase). The effects of FK143 on prostate size and histopathology of mature male beagle dogs were investigated and compared with those of finasteride (a steroidal 5 alpha-reductase inhibitor), and allylestrenol and chlormadinone acetate (CMA) (androgen receptor antagonists). FK143 was orally administered to the dogs daily for 12 weeks. At doses of 10 and 32 mg/kg, FK143 significantly reduced prostate volume to about 60% of the initial value, and dogs treated with FK143 showed a dose-dependent glandular epithelial atrophy in the prostate. FK143 showed no abnormal changes in organ weights and histopathology of the adrenal, testis, pituitary and liver. The degree of prostate reduction in the dogs treated with FK143 (10 and 32 mg/kg) was almost the same as that by finasteride (1.0 mg/kg) and smaller than that by allylestrenol (10 mg/kg) or CMA (10 mg/kg). However, allylestrenol increased liver weights, and CMA increased liver and reduced adrenal weights. These results demonstrate that FK143 can decrease the volume of the dog prostate without any influence on other organs, and they suggest that FK143 is a good candidate for the treatment for benign prostatic hyperplasia.  (+info)

Effects of steroid 5alpha-reductase inhibitor ONO-9302 and anti-androgen allylestrenol on the prostatic growth, and plasma and prostatic hormone levels in rats. (5/5)

ONO-9302 [epristeride; (-)-17beta-(tert-butylcarbamoyl)androsta-3,5-diene-3-carboxy lic acid] is a novel inhibitor of steroid 5alpha-reductase. We studied in vitro and in vivo effects of ONO-9302 on the rat prostatic tissue in comparison with those of the anti-androgen allylestrenol. ONO-9302 inhibited the rat prostatic enzyme with an IC50 value of 11 nM, whereas allylestrenol was about 80,000-fold less potent. The growth of ventral prostate, which was induced by the subcutaneous injection of testosterone propionate in the castrated rats, was significantly reduced by ONO-9302 at oral doses of 1-100 mg/kg/day. Allylestrenol showed a significant effect only at a dose of 100 mg/kg/day. In mature male rats, ONO-9302 significantly reduced the ventral prostate weight at doses of 10-100 mg/kg/day and decreased prostatic 5alpha-dihydrotestosterone (DHT) content associated with a rise in testosterone (T) content at doses of 0.1-100 mg/kg/day. Plasma hormone levels (i.e., T, DHT, luteinizing hormone (LH) and follicle stimulating hormone (FSH)) were not altered significantly. Allylestrenol significantly reduced the ventral prostate weight at doses of 10-100 mg/kg/day. However, unlike ONO-9302, allylestrenol reduced both the prostatic DHT and T contents and also lowered plasma T, DHT, LH and FSH levels at a dose of 30 mg/kg/day. These results suggest that ONO-9302 reduces the prostatic growth by inhibiting the conversion of T to DHT in the prostate without lowering blood T level unlike anti-androgen drugs.  (+info)

Allylestrenol is a synthetic progestogen medication, which is a type of steroid hormone. It is similar in structure to the natural female sex hormone progesterone and is used in the treatment of various gynecological conditions such as menstrual disorders, endometriosis, and threatened miscarriage.

Progestogens are important for maintaining pregnancy by supporting the lining of the uterus (endometrium) and preventing muscle contractions that could lead to a miscarriage. Allylestrenol has been used as an alternative to natural progesterone because it is more potent and has a longer duration of action.

However, like other synthetic hormones, allylestrenol can cause side effects such as nausea, vomiting, headache, breast tenderness, mood changes, and irregular menstrual bleeding. It should be used with caution in women with a history of thromboembolic disease (blood clots) or liver dysfunction.

It is important to note that the use of allylestrenol and other hormonal medications should always be under the supervision of a healthcare professional, who can monitor their effectiveness and potential side effects.

Progesterone congeners refer to synthetic or naturally occurring compounds that are structurally similar to progesterone, a steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis. These compounds have similar chemical structures to progesterone and may exhibit similar physiological activities, although they can also have unique properties and uses. Examples of progesterone congeners include various synthetic progestins used in hormonal contraceptives and other medical treatments.

... has no androgenic or other off-target hormonal side effects. Allylestrenol is a progestogen, or an agonist of the ... In Japan, a 25 mg allylestrenol oral tablet, under the brand name Perselin, is marketed for the treatment of BPH. Allylestrenol ... Chemical syntheses of allylestrenol have been published. Allylestrenol was patented in 1958 and has been marketed for medical ... is a known active metabolite of allylestrenol. The biological half-life of allylestrenol has been reported to be "several hours ...
The products of Naari include: Active Pharmaceutical Ingredients (APIs) • Allylestrenol • Disulfiram • Estradiol • Estradiol ... Allylestrenol 5 mg) • Regelle tablets (Norethisterone BP 5 mg) Diagnostics • U-Chek (HCG pregnancy test kit) • Ova -Chek (LH ...
Allylestrenol M. Tausk (1975). Pharmacology of hormones. Thieme. p. 126,129. ISBN 978-3-13-518901-7. Concours médical. 1976. p ...
... allylestrenol, (43), (44) altrenogest. Bergink EW, Loonen PB, Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol ... ISBN 978-0-444-88727-6. Other examples are allylestrenol (42), a pro-drug converted to the 3-keto analogue (43), which is used ... Madjerek Z, De Visser J, Van Der Vies J, Overbeek GA (September 1960). "Allylestrenol, a pregnancy maintaining oral gestagen". ... Allyltestosterone is the parent structure of two marketed 19-nortestosterone progestins, allylestrenol and altrenogest. These ...
... allylestrenol, (43), (44) altrenogest. Bergink EW, Loonen PB, Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol ... These findings may help to explain the absence of teratogenic effects of allylestrenol on the external genitalia of female and ... ISBN 978-0-444-88727-6. Other examples are allylestrenol (42), a pro-drug converted to the 3-keto analogue (43), which is used ... Madjerek Z, De Visser J, Van Der Vies J, Overbeek GA (September 1960). "Allylestrenol, a pregnancy maintaining oral gestagen". ...
It is one of only two marketed progestins that possesses a 17α-allyl group, the other being allylestrenol. Most other ... ISBN 978-0-444-88727-6. Other examples are allylestrenol (42), a pro-drug converted to the 3-keto analogue (43), which is used ... and allylestrenol (ratio for all < 1.0), whereas the AR/PR activational potency ratio of its 17α-deallylated AAS analogue ... similarly to the use of allylestrenol to maintain pregnancy in women) with no incidence of virilization or other abnormalities ...
Prodrugs (lack 3-keto): Ethylestrenol, Lynestrenol, Ethynodiol, Allylestrenol, Norgestimate De-Wei Z (1982). "Research ...
Bergink EW, Loonen PB, Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol, a progestagen of the 19- ...
... and allylestrenol. They are used questionably for treatment of recurrent pregnancy loss and for prevention of preterm birth in ... allylestrenol, dimethisterone, medroxyprogesterone acetate, megestrol acetate, norelgestromin, noretynodrel, norgesterone ...
Bergink EW, Loonen PB, Kloosterboer HJ (1985). "Receptor binding of allylestrenol, a progestagen of the 19-nortestosterone ... and allylestrenol (compare to the AAS ethylestrenol). Studies with steroids similar to dienogest (e.g., dienolone) have found ...
Bergink EW, Loonen PB, Kloosterboer HJ (August 1985). "Receptor binding of allylestrenol, a progestagen of the 19- ...
Double-blind comparative studies on allylestrenol and chlormadinone acetate Part I: Nocturnal penile tumescence monitoring]". ...
Prodrugs (lack 3-keto): Ethylestrenol, Lynestrenol, Ethynodiol, Allylestrenol, Norgestimate C.H. Lingeman (6 December 2012). ...
Double-blind comparative studies on allylestrenol and chlormadinone acetate Part I: Nocturnal penile tumescence monitoring]" ( ...
... allylestrenol) that do not. The only progestogens currently used during pregnancy (e.g., for luteal support in IVF protocols or ... and allylestrenol. Doses of 19-nortestosterones required for virilization are 10 to 20 mg/day, far in excess of those ...
An ethynyl group (e.g., ethisterone, norethisterone), allyl group (e.g., allylestrenol), or vinyl group (e.g., norvinisterone) ...
Other progestogens including medroxyprogesterone acetate, lynestrenol, allylestrenol, dydrogesterone, and normethandrone have ...
The antiandrogens chlormadinone acetate and oxendolone and the functional antiandrogens allylestrenol and gestonorone caproate ... progestogens like allylestrenol, chlormadinone acetate, cyproterone acetate, gestonorone caproate, hydroxyprogesterone caproate ...
... allylestrenol (INN) allylprodine (INN) allylthiourea (INN) almadrate sulfate (INN) almagate (INN) almagodrate amcinonide (INN) ...
... approved specifically for the treatment of painful endometriosis Acetomepregenol Algestone acetophenide Allylestrenol ...
... and allylestrenol (17α-allyl-3-deketo-19-nortestosterone) (an extended-chain variant of ethylestrenol). Conversely, replacement ...
It has been found to suppress luteinizing hormone and testosterone levels to an equivalent extent as allylestrenol and ...
The C17α allyl derivatives allylestrenol (3-deketo-17α-allyl-19-NT) and altrenogest (17α-allyl-δ9,11-19-NT) The C17α alkyl ...
G03DB04 Nomegestrol G03DB05 Demegestone G03DB06 Chlormadinone G03DB07 Promegestone G03DB08 Dienogest G03DC01 Allylestrenol ...
The progestins allylestrenol (3-deketo-17α-allyl-19-NT) and lynestrenol (3-deketo-17α-ethynyl-19-NT) are also closely related ...
... allylestrenol MeSH D04.808.365.415.200 - epimestrol MeSH D04.808.365.415.215 - equilenin MeSH D04.808.365.415.220 - equilin ...
Allylestrenol has no androgenic or other off-target hormonal side effects. Allylestrenol is a progestogen, or an agonist of the ... In Japan, a 25 mg allylestrenol oral tablet, under the brand name Perselin, is marketed for the treatment of BPH. Allylestrenol ... Chemical syntheses of allylestrenol have been published. Allylestrenol was patented in 1958 and has been marketed for medical ... is a known active metabolite of allylestrenol. The biological half-life of allylestrenol has been reported to be "several hours ...
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ATXHVCQZZJYMCF-XUDSTZEESA-N Allylestrenol Chemical compound C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)CC=C)[C@@H]4[C@@H]3CCC2=C1 ...
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  • Allylestrenol is available in the form of 5 mg oral tablets. (wikipedia.org)
  • Best Allylestrenol 5 Mg Tablets Manufacturers in India Believe in our dedication to quality and innovation as we work to improve healthcare throughout the world. (scazonhealthcare.com)
  • In Japan, a 25 mg allylestrenol oral tablet, under the brand name Perselin, is marketed for the treatment of BPH. (wikipedia.org)
  • Medicines apart from Maintane containing Allylestrenol and those which have similar therapeutic action to Maintane, can be used as an alternative to this tablet. (medifee.com)
  • Allylestrenol, sold under the brand names Gestanin and Turinal among others, is a progestin medication which is used to treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women. (wikipedia.org)
  • Allylestrenol is used in the treatment of recurrent and threatened miscarriage and to prevent premature labor. (wikipedia.org)
  • Indication: Allylestrenol was designed to be used for miscarriage prevention, prevention of premature labour and has been investigated for possible use in men for treatment for benign prostatic hyperplasia. (medicatione.com)
  • Allylestrenol is a progestogen structurally related to progesterone that has been given in threatened and recurrent miscarriage, and to prevent premature labour. (medicatione.com)
  • Allylestrenol is used to prevent miscarriage, which is the impulsive loss of the fetus and termination of the pregnancy within the first 20 weeks. (scazonhealthcare.com)
  • Allylestrenol is used to prevent preterm labor, a condition where the body gets ready to give birth much earlier than the expected due date. (scazonhealthcare.com)
  • Allylestrenol is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. (wikipedia.org)
  • Allylestrenol is a progestogen, or an agonist of the progesterone receptor (PR). (wikipedia.org)
  • Allylestrenol is a far less potent progestogen than many other 19-nortestosterone derivatives. (wikipedia.org)
  • Unlike virtually all other 19-nortestosterone derivatives, allylestrenol is reported to be a pure progestogen and hence to be devoid of androgenic, estrogenic, and glucocorticoid activity. (wikipedia.org)
  • Unlike other progestins, allylestrenol has not been used in hormonal contraception or in menopausal hormone therapy. (wikipedia.org)
  • Allylestrenol has no androgenic or other off-target hormonal side effects. (wikipedia.org)
  • Allylestrenol acts by inhibiting the hormonal surge which occurs during ovulation and prevents loss of pregnancy. (medifee.com)
  • Allylestrenol is one of only a handful of progestogens that has commonly been used for such purposes, the others including progesterone, hydroxyprogesterone caproate, and dydrogesterone. (wikipedia.org)
  • The active ingredient of Maintane is Allylestrenol, which is a type of estrogen. (medifee.com)
  • What is the time duration Allylestrenol drug must be taken for it to be effective or for it to reduce the symptoms? (medicatione.com)
  • The duration of Allylestrenol treatment may vary depending on the specific condition being treated and individual factors. (scazonhealthcare.com)
  • The binding and activity profiles of allylestrenol and its major active metabolite at steroid hormone receptors and related proteins have been studied. (wikipedia.org)
  • Side effects of allylestrenol are few and have not been well-defined, but are assumed to be similar to those of related medications. (wikipedia.org)
  • The effective ovulation-inhibiting or contraceptive dosage of allylestrenol in women has been studied, albeit limitedly. (wikipedia.org)
  • The total endometrial transformation dosage of allylestrenol in women across the cycle is 150 to 250 mg. (wikipedia.org)
  • Allylestrenol 5 mg is a medication that belongs to the class of drugs known as progestogens. (scazonhealthcare.com)
  • Allylestrenol was first described in 1958 and was introduced for medical use by 1961. (wikipedia.org)
  • Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using allylestrenol. (wikipedia.org)
  • Depending on the reaction of the Allylestrenol after taken, if you are feeling dizziness, drowsiness or any weakness as a reaction on your body, Then consider Allylestrenol not safe to drive or operate heavy machine after consumption. (medicatione.com)
  • On the other hand, allylestrenol was found to be effective in the treatment of hot flashes in postmenopausal women. (wikipedia.org)
  • Allylestrenol has also been studied in the treatment of prostate cancer in Japan. (wikipedia.org)
  • When used at high dosages in the treatment of BPH in men, allylestrenol can cause symptoms of hypogonadism and sexual dysfunction. (wikipedia.org)
  • It is noteworthy that the product of the survey is based on the perception and impressions of the visitors of the website as well as the views of Allylestrenol consumers. (medicatione.com)
  • Allylestrenol is available in the form of 5 mg oral tablets. (wikipedia.org)
  • A simple and rapid densitometric method has been developed for determination of allylestrenol in tablets. (unair.ac.id)
  • The total endometrial transformation dosage of allylestrenol in women across the cycle is 150 to 250 mg. (wikipedia.org)
  • The effect of estradiol valerate and allylestrenol on endometrial transformation in hypergonadotropic hypogonadic women. (libguides.com)
  • Unlike other progestins, allylestrenol has not been used in hormonal contraception or in menopausal hormone therapy. (wikipedia.org)
  • The binding and activity profiles of allylestrenol and its major active metabolite at steroid hormone receptors and related proteins have been studied. (wikipedia.org)
  • 22. Effects of steroid 5alpha-reductase inhibitor ONO-9302 and anti-androgen allylestrenol on the prostatic growth, and plasma and prostatic hormone levels in rats. (nih.gov)
  • Allylestrenol has been commonly used in Japan at high dosages, typically 50 mg/day but as much as 100 mg/day, to treat BPH in men. (wikipedia.org)
  • When used at high dosages in the treatment of BPH in men, allylestrenol can cause symptoms of hypogonadism and sexual dysfunction. (wikipedia.org)
  • On the other hand, allylestrenol was found to be effective in the treatment of hot flashes in postmenopausal women. (wikipedia.org)
  • We find 172 products about allylestrenol from 159 manufacturers & suppliers. (china.cn)